quinazolines has been researched along with 5,8-dideazaisofolic acid in 17 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (70.59) | 18.7374 |
| 1990's | 5 (29.41) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fukunaga, JY; Hansch, C; Steller, EE | 1 |
| Cesar, D; Coll, RJ; Hynes, JB; Shane, B | 1 |
| Duch, DS; Freisheim, JH; Hagan, RL; Hanlon, MH; Hynes, JB; Shane, B; Smith, GK | 1 |
| Bertino, JR; McGuire, JJ; Sobrero, AF | 1 |
| Cole, A; Freisheim, JH; Hagan, RL; Hynes, JB; Kohler, W; Patil, SA | 1 |
| Cranford, SK; Fernandes, DJ | 1 |
| Bertino, JR; Sobrero, AF | 1 |
| Bertino, JR; Handschumacher, RE; Sobrero, AF | 1 |
| Bertino, JR; Hynes, JB; McGuire, JJ; Sobrero, AF | 1 |
| Gale, GR; Hynes, JB; Smith, AB | 1 |
| Bertino, JR; Cardenas, RM; Fernandes, DJ; Hynes, JB | 1 |
| Harmon, SJ; Hynes, JB; McGill, JE; Washtien, WL; Yang, YC | 1 |
| Bertino, JR; Fernandes, DJ; Hynes, JB | 1 |
| Fudenberg, HH; Hynes, JB; Tsang, KY | 1 |
| Hagan, RL; Hynes, JB; Kisliuk, RL; Pimsler, M | 1 |
| Fetzer, OS; Freisheim, JH; Hynes, JB; Shane, B | 1 |
| Freisheim, JH; Hagan, RL; Hynes, JB; Shane, B | 1 |
17 other study(ies) available for quinazolines and 5,8-dideazaisofolic acid
| Article | Year |
|---|---|
Inhibition of dihydrofolate reductase. Structure-activity correlations of quinazolines.
Topics: Binding Sites; Folic Acid Antagonists; Liver; Molecular Conformation; Quinazolines; Structure-Activity Relationship | 1976 |
In vitro metabolism of 5,8-dideazafolates and 5,8-dideazaisofolates by mammalian folylpoly-gamma-glutamate synthetase.
Topics: Aminopterin; Animals; Folic Acid Antagonists; Kinetics; Liver; Peptide Synthases; Pteroylpolyglutamic Acids; Quinazolines; Structure-Activity Relationship; Substrate Specificity | 1991 |
Studies on the mechanism of antitumor action of 2-desamino-2-methyl-5,8-dideazaisofolic acid.
Topics: Animals; Antineoplastic Agents; Carrier Proteins; Drug Screening Assays, Antitumor; Folate Receptors, GPI-Anchored; Folic Acid Antagonists; Kinetics; Methotrexate; Peptide Synthases; Quinazolines; Receptors, Cell Surface; Thymidylate Synthase; Tumor Cells, Cultured | 1991 |
Uptake and metabolism of 5,8-dideazaisofolic acid in human colon carcinoma cells.
Topics: Adenocarcinoma; Biotransformation; Colonic Neoplasms; Folic Acid Antagonists; Humans; Methotrexate; Polyglutamic Acid; Quinazolines; Thymidylate Synthase; Tumor Cells, Cultured | 1988 |
Comparison of the biological effects of selected 5,8-dideazafolate analogues with their 2-desamino counterparts.
Topics: Animals; Chemical Phenomena; Chemistry; Folic Acid; Folic Acid Antagonists; Humans; Leukemia L1210; Methotrexate; Quinazolines; Structure-Activity Relationship; Thymidylate Synthase | 1989 |
Dissociation of thymidylate biosynthesis from DNA biosynthesis by 5-fluoro-2'-deoxyuridine and 5,8-dideazaisofolic acid.
Topics: Deoxyguanine Nucleotides; DNA; DNA Polymerase II; Dose-Response Relationship, Drug; Floxuridine; Folic Acid Antagonists; Humans; Leukemia; Pyrimethamine; Quinazolines; Thymidine Monophosphate; Thymidylate Synthase; Thymine Nucleotides | 1986 |
Endogenous thymidine and hypoxanthine are a source of error in evaluating methotrexate cytotoxicity by clonogenic assays using undialyzed fetal bovine serum.
Topics: Adenocarcinoma; Animals; Cattle; Cell Adhesion; Colonic Neoplasms; Colony-Forming Units Assay; Culture Media; Dose-Response Relationship, Drug; Humans; Hypoxanthines; Leucovorin; Methotrexate; Neoplastic Stem Cells; Quinazolines; Thymidine; Trimetrexate | 1986 |
Highly selective drug combinations for human colon cancer cells resistant in vitro to 5-fluoro-2'-deoxyuridine.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Biological Transport; Cell Line; Colonic Neoplasms; Drug Resistance; Floxuridine; Humans; Hypoxanthine; Hypoxanthines; Methotrexate; Nucleosides; Quinazolines; Thymidine | 1985 |
Mechanism of action of 5,8-dideazaisofolic acid and other quinazoline antifols in human colon carcinoma cells.
Topics: Cell Survival; Colonic Neoplasms; Drug Resistance; Drug Screening Assays, Antitumor; Folic Acid Antagonists; Humans; Quinazolines; Structure-Activity Relationship; Tumor Cells, Cultured | 1987 |
Effects of 5,8-dideazaisopteroylglutamate (IAHQ) on L1210 leukemia in mice when given alone and in combination with methotrexate, probenecid, or verapamil.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Folic Acid Antagonists; Leukemia L1210; Male; Methotrexate; Mice; Mice, Inbred DBA; Probenecid; Quinazolines; Time Factors; Verapamil | 1986 |
Effects of 5,8-dideazaisopteroylglutamate and its possible tri-gamma-glutamyl metabolite (5,8-dideazaisoPteGlu3) on colon adenocarcinoma, and the folate dependent enzymes thymidylate synthase and dihydrofolate reductase.
Topics: Adenocarcinoma; Animals; Cell Line; Colonic Neoplasms; DNA Replication; Drug Resistance; Female; Humans; Kinetics; Leukemia; Methotrexate; Methyltransferases; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Peptide Synthases; Quinazolines; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase | 1983 |
Improved synthesis and antitumor evaluation of 5,8-dideazaisofolic acid and closely related analogues.
Topics: Adenocarcinoma; Antineoplastic Agents; Cell Line; Chemical Phenomena; Chemistry; Folic Acid Antagonists; Gastrointestinal Neoplasms; Humans; Methotrexate; Quinazolines; Stereoisomerism; Structure-Activity Relationship | 1984 |
Biochemical and antitumor effects of 5,8-dideazaisopteroylglutamate, a unique quinazoline inhibitor of thymidylate synthase.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cell Line; Colonic Neoplasms; Female; Folic Acid Antagonists; Humans; Leukemia L1210; Methotrexate; Methyltransferases; Mice; Mice, Inbred C57BL; Quinazolines; Thymidylate Synthase | 1983 |
Effects of 5,8-dideazaisofolic acid (IAHQ) on human tumor cells in culture and on normal and tumor-bearing hamsters.
Topics: Animals; Cell Division; Cell Line; Cricetinae; Cytotoxicity, Immunologic; Drug Resistance; Female; Folic Acid Antagonists; Humans; Lymphocyte Activation; Methotrexate; Neoplasms; Osteosarcoma; Pregnancy; Quinazolines; Sarcoma, Experimental | 1982 |
Studies on the antitumor effects of analogues of 5,8-dideazaisofolic acid and 5,8-dideazaisoaminopterin.
Topics: Aminopterin; Antineoplastic Agents; Cell Death; Folic Acid Antagonists; Humans; Quinazolines; Structure-Activity Relationship; Thymidylate Synthase; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1995 |
Synthesis and preliminary biological evaluation of analogues of 5,8-dideazaisofolic acid and its 2-desamino-2-methyl derivative containing fluorine at position five.
Topics: Animals; Cell Survival; Fluorine; Folic Acid Antagonists; Leukemia L1210; Liver; Methotrexate; Mice; Peptide Synthases; Quinazolines; Structure-Activity Relationship; Swine; Tumor Cells, Cultured | 1993 |
Synthesis and biological evaluation of analogues of 5,8-dideazaisofolic acid (IAHQ) modified at positions 2, 4 and 9.
Topics: Animals; Cell Survival; Folic Acid Antagonists; Kinetics; Leukemia L1210; Liver; Mice; Peptide Synthases; Quinazolines; Structure-Activity Relationship; Swine; Tumor Cells, Cultured | 1993 |