quinazolines has been researched along with 5,10-methylenetetrahydrofolic acid in 13 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.69) | 18.7374 |
| 1990's | 9 (69.23) | 18.2507 |
| 2000's | 3 (23.08) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jackman, AL; Kimbell, R; Ward, WH | 1 |
| Goldman, ID; Mikulecky, DC; Rape, TJ; Seither, RL; Trent, DF | 1 |
| Maley, F; Maley, GF | 1 |
| Connick, TJ; Dunlap, RB; Ellis, PD; Reilly, RT | 1 |
| Haile, WH; Heitzman, KJ; McCloskey, DE; McGuire, JJ; Piper, JR; Russell, CA | 1 |
| Banks, S; Dev, IK; Dickerson, SH; Duch, DS; Ferone, R; Heath, LS; Humphreys, J; Knick, V; Pendergast, W; Singer, S | 1 |
| Malmberg, M; Rustum, YM; Slocum, HK; Yin, MB; Zhang, ZG | 1 |
| Birdsall, DL; Finer-Moore, J; Stroud, RM | 1 |
| Appleman, JR; Spencer, HT; Villafranca, JE | 1 |
| Biermann, D; Finer-Moore, J; Michelitsch, MD; Nissen, R; Sage, CR; Stout, TJ; Stroud, RM | 1 |
| Berger, FG; Fantz, C; Forsthoefel, A; Jennings, W; Kitchens, M; Lebioda, L; Minor, W; Phan, J; Shaw, D; Spencer, HT | 1 |
| Finer-Moore, JS; Fritz, TA; Liu, L; Stroud, RM | 1 |
| Anderson, KS; Atreya, CE; Doan, LT; Martucci, WE; Vargo, MA | 1 |
13 other study(ies) available for quinazolines and 5,10-methylenetetrahydrofolic acid
| Article | Year |
|---|---|
Kinetic characteristics of ICI D1694: a quinazoline antifolate which inhibits thymidylate synthase.
Topics: Animals; Binding Sites; Cell Division; Kinetics; Leukemia L1210; Mice; Quinazolines; Tetrahydrofolates; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 1992 |
Effect of direct suppression of thymidylate synthase at the 5,10-methylenetetrahydrofolate binding site on the interconversion of tetrahydrofolate cofactors to dihydrofolate by antifolates. Influence of degree of dihydrofolate reductase inhibition.
Topics: Animals; Folic Acid Antagonists; In Vitro Techniques; Leukemia L1210; Methotrexate; Mice; Quinazolines; Quinazolinones; Tetrahydrofolates; Thermodynamics; Thymidylate Synthase; Trimetrexate; Tumor Cells, Cultured | 1991 |
Properties of a defined mutant of Escherichia coli thymidylate synthase.
Topics: Amino Acids; Cysteine; Escherichia coli; Fluorodeoxyuridylate; Folic Acid; Mutation; Peptide Mapping; Quinazolines; Structure-Activity Relationship; Tetrahydrofolates; Thymidylate Synthase; Tyrosine | 1988 |
Phosphorus-31 nuclear magnetic resonance studies of complexes of thymidylate synthase.
Topics: Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Folic Acid; Magnetic Resonance Spectroscopy; Phosphorus Isotopes; Quinazolines; Tetrahydrofolates; Thymidine Monophosphate; Thymidylate Synthase | 1994 |
Cross-resistance studies of folylpolyglutamate synthetase-deficient, methotrexate-resistant CCRF-CEM human leukemia sublines.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Cell Division; Drug Resistance; Folic Acid Antagonists; Humans; Leucovorin; Methotrexate; Peptide Synthases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrimidines; Quinazolines; Tetrahydrofolates; Thiophenes; Tumor Cells, Cultured | 1993 |
Biochemical and cellular pharmacology of 1843U89, a novel benzoquinazoline inhibitor of thymidylate synthase.
Topics: Animals; Binding, Competitive; Breast Neoplasms; Cell Division; Colonic Neoplasms; Female; Humans; Indoles; Isoindoles; Leucovorin; Leukemia L1210; Leukemia, T-Cell; Methotrexate; Quinazolines; Structure-Activity Relationship; Subrenal Capsule Assay; Tetrahydrofolates; Thymidylate Synthase | 1993 |
Isolation and characterization of a human ileocecal carcinoma cell line (HCT-8) subclone resistant to fluorodeoxyuridine.
Topics: Antimetabolites, Antineoplastic; Cell Division; Colonic Neoplasms; Drug Resistance; Floxuridine; Fluorouracil; Humans; Methotrexate; Quinazolines; Tetrahydrofolates; Thiophenes; Thymidine Kinase; Thymidine Phosphorylase; Thymidylate Synthase; Tumor Cells, Cultured | 1993 |
Entropy in bi-substrate enzymes: proposed role of an alternate site in chaperoning substrate into, and products out of, thymidylate synthase.
Topics: Binding Sites; Crystallography, X-Ray; Deoxyuracil Nucleotides; Folic Acid; Lacticaseibacillus casei; Models, Molecular; Protein Conformation; Quinazolines; Tetrahydrofolates; Thermodynamics; Thymidylate Synthase | 1996 |
Kinetic scheme for thymidylate synthase from Escherichia coli: determination from measurements of ligand binding, primary and secondary isotope effects, and pre-steady-state catalysis.
Topics: Catalysis; Deoxyuracil Nucleotides; Escherichia coli; Folic Acid; Folic Acid Antagonists; Kinetics; Ligands; Molecular Structure; Mutagenesis, Site-Directed; Protein Binding; Protein Conformation; Quinazolines; Spectrometry, Fluorescence; Spectrophotometry; Tetrahydrofolates; Thermodynamics; Thymidine Monophosphate; Thymidylate Synthase | 1997 |
D221 in thymidylate synthase controls conformation change, and thereby opening of the imidazolidine.
Topics: Asparagine; Aspartic Acid; Binding Sites; Crystallography, X-Ray; Escherichia coli; Fluorodeoxyuridylate; Folic Acid; Hydrogen Bonding; Imidazoles; Macromolecular Substances; Models, Molecular; Mutagenesis, Site-Directed; Protein Binding; Protein Conformation; Quinazolines; Substrate Specificity; Tetrahydrofolates; Thymidylate Synthase | 1998 |
Drug-resistant variants of Escherichia coli thymidylate synthase: effects of substitutions at Pro-254.
Topics: Amino Acid Substitution; Crystallography, X-Ray; Deoxyuracil Nucleotides; Drug Resistance; Drug Resistance, Microbial; Enzyme Inhibitors; Escherichia coli; Fluorodeoxyuridylate; Folic Acid Antagonists; Humans; Kinetics; Mutation; Proline; Protein Conformation; Quinazolines; Tetrahydrofolates; Thymidylate Synthase; Transfection | 2000 |
Tryptophan 80 and leucine 143 are critical for the hydride transfer step of thymidylate synthase by controlling active site access.
Topics: Binding Sites; Biological Transport; Deoxyuracil Nucleotides; Escherichia coli; Folic Acid; Leucine; Models, Chemical; Point Mutation; Protons; Quinazolines; Tetrahydrofolates; Thymidylate Synthase; Tryptophan | 2002 |
Nonconserved residues Ala287 and Ser290 of the Cryptosporidium hominis thymidylate synthase domain facilitate its rapid rate of catalysis.
Topics: Alanine; Amino Acid Sequence; Animals; Binding Sites; Catalysis; Chromatography, High Pressure Liquid; Cryptosporidium; Crystallography, X-Ray; Folic Acid; Kinetics; Models, Molecular; Molecular Sequence Data; Multienzyme Complexes; Mutagenesis, Site-Directed; Protein Structure, Tertiary; Protozoan Proteins; Quinazolines; Serine; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Thymidine Monophosphate; Thymidylate Synthase | 2007 |