Page last updated: 2024-08-21

quinazolines and 4-aminoquinazoline

quinazolines has been researched along with 4-aminoquinazoline in 31 studies

Research

Studies (31)

Timeframe	Studies, this research(%)	All Research%
pre-1990	3 (9.68)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	21 (67.74)	24.3611
2020's	7 (22.58)	2.80

Authors

Authors	Studies
Fukunaga, JY; Hansch, C; Steller, EE	1
BASU, PC; DHATT, MS; SINGH, H	1
BEUTEL, RH; STEVENS, JR; WOLF, FJ	1
Ji, XL; Li, YL; Lin, MS; Song, SH; Tang, LD; Wu, CF; Yu, B	1
Chaudhary, A; Kumar, A; Roy, RK; Sharma, PP; Singh, K	1
Chen, Y; Ding, R; Feng, M; He, Y; Li, S; Ning, H; Qi, C; Wang, X; Xu, J	1
An, L; Gong, X; Gu, N; Ji, M; Liu, Y; Wu, X; Xue, B; Xue, Y; Zhan, X; Zhang, L; Zheng, M; Zheng, Y	1
Abel, U; Ambartsumova, R; Hechenberger, M; Kauss, V; Krueger, B; Kubas, H; Meyer, U; Polosukhin, AI; Pyatkin, I; Vanejevs, M; Zemribo, R	1
Aoi, H; Boriack-Sjodin, PA; Doig, P; Dumas, J; Hu, J; Itoh, K; Johnson, K; Kazmirski, S; Kinoshita, T; Kuroda, S; Sato, TO; Sugimoto, K; Tohyama, K; Wakamatsu, K; Wang, H	1
Cai, J; Cao, M; Chen, J; Hong, KH; Ji, M; Li, L; Wang, P; Wu, X; Zong, X	1
Ahmadiiveli, A; Carson, DA; Chan, M; Corr, M; Cottam, HB; Crain, B; Hayashi, T; Kouznetsova, VL; Messer, K; Nour, A; Pu, M; Tawatao, RI; Tsigelny, IF; Yao, S	1
Harrity, JP; Maiden, TM; Procopiou, PA; Swanson, S	1
Alsaid, MS; Ghorab, MM	1
Alsaid, MS; Dinkova-Kostova, AT; El-Gazzar, MG; Ghorab, MM; Higgins, M; Shahat, AA	1
Chen, S; Chen, YZ; Ding, C; Hu, G; Jiang, Y; Li, L; Tan, C; Zhang, C; Zhang, W	1
Cheng, M; Guo, J; Hao, C; He, Z; Huan, R; Huang, W; Jiang, X; Li, F; Li, H; Li, X; Lin, B; Liu, T; Lu, T; Pang, Y; Song, H; Song, S; Wang, J; Wang, K; Wang, R; Zhang, Q; Zhao, D; Zhao, F	1
Chai, SM; Chen, K; Deng, CL; Ding, HW; Li, DD; Li, X; Liu, DD; Song, HR; Song, SJ; Wang, J; Wang, W; Zhang, Y	1
Ding, HW; Fan, YH; Liu, DD; Song, HR; Wang, J; Xu, YN	1
Hong, K; Huai, Z; Huang, Y; Li, S; Liu, F; Liu, G; Song, L; Xia, G; Xu, Y; Yao, M	1
Liu, Q; Long, L; Lu, G; Tu, ZC; Wang, YH; Wu, R; Yan, M; Zhuo, JX	1
Aro, A; Choong, YS; Maluleka, MM; McGaw, LJ; Mphahlele, MJ	1
Das, D; Hong, J	1
Ding, HW; Qin, XC; Song, HR; Song, SJ; Wang, J; Wang, S; Zhao, QC	1
Dolšak, A; Gobec, S; Konc, J; Lešnik, S; Sova, M; Švajger, U	1
Karpoormath, R; Palkar, M; Patel, HM	1
Ding, H; Liu, Y; Lu, H; Qin, X; Ren, T; Wang, S; Wu, Q; Zhang, Y; Zhao, Q	1
Chu, B; Ding, C; Fan, T; Jiang, Y; Shi, Z; Sun, Q; Tan, C; Yuan, Z; Zhang, C; Zhao, L	1
Arnhof, H; Bader, G; Böttcher, J; Ettmayer, P; Gerstberger, T; Gmachl, M; Haering, D; Hauer, K; Hela, W; Hofmann, MH; Kennedy, MD; Kessler, D; Kofink, C; Kraut, N; Lamarre, L; McConnell, DB; Mendes, RL; Meyer, R; Munico-Martinez, S; O'Connell, JC; Pototschnig, N; Ramharter, J; Richard, D; Rumpel, K; Salamon, C; Sanderson, M; Schnitzer, R; Weiner, I; Werni, P; Wolkerstorfer, B; Wunberg, T; Zöphel, A	1
Abibi, A; Al-Awar, R; Aman, A; Chung, KC; Griffin, C; Grouleff, J; Isaac, MB; Joseph, B; Kiyota, T; Konda, JD; Ler, S; Leung-Hagesteijn, C; Marcellus, R; Poda, G; Prakesch, MA; Strathdee, CA; Subramaniam, R; Tiedemann, RE; Uehling, DE; Zhang, AX	1
Chen, D; Chen, L; Chen, P; Chen, Y; Hu, J; Liang, G; Peng, T; Tang, Q; Tong, L; Wang, Y; Xie, H; Zhang, T	1
Akao, Y; Akther, T; Canan, S; Cao, Y; Chowdhury, S; Condroski, K; Engkvist, O; Francisco, A; Ghosh, S; Itono, S; Kaki, R; Kamaura, M; Kelly, JM; Kimura, C; Kogej, T; Mowbray, C; Nagaoka, K; Naito, A; Ochida, A; Pairaudeau, G; Perry, B; Radu, C; Roberts, I; Shimada, M; Shum, D; Tawaraishi, T; Watanabe, NA; Xie, H; Yonezawa, S; Yoshida, O; Yoshida, R	1

Reviews

2 review(s) available for quinazolines and 4-aminoquinazoline

Article	Year
4-aminoquinazoline analogs: a novel class of anticancer agents. Mini reviews in medicinal chemistry, 2013, Jun-01, Volume: 13, Issue:8 Topics: Antineoplastic Agents; Drug Discovery; ErbB Receptors; Humans; Neoplasms; Quinazolines	2013
Recent advancements of 4-aminoquinazoline derivatives as kinase inhibitors and their applications in medicinal chemistry. European journal of medicinal chemistry, 2019, May-15, Volume: 170 Topics: Animals; Antineoplastic Agents; Chemistry Techniques, Synthetic; Humans; Neoplasms; Protein Kinase Inhibitors; Quinazolines	2019

Other Studies

29 other study(ies) available for quinazolines and 4-aminoquinazoline

Article	Year
Inhibition of dihydrofolate reductase. Structure-activity correlations of quinazolines. Journal of medicinal chemistry, 1976, Volume: 19, Issue:5 Topics: Binding Sites; Folic Acid Antagonists; Liver; Molecular Conformation; Quinazolines; Structure-Activity Relationship	1976
SCREENING OF POTENTIAL ANTIMALARIALS AGAINST P. GALLINACEUM IN CHICKS. IX. SOME DERIVATIVES OF 4-AMINOQUINAZOLINE, 4 (3)-QUINAZOLONE,4-AMINO-BENZ (H) QUINALDINE, BIGUANIDES AND CERTAIN INDIGENOUS DRUGS. Indian journal of physiology and pharmacology, 1964, Volume: 8 Topics: Animals; Antimalarials; Biguanides; Chickens; Guanidines; Heterocyclic Compounds; India; Malaria; Malaria, Avian; Pharmacology; Plasmodium; Poultry; Quinaldines; Quinazolines; Quinolines; Research; Toxicology	1964
2-Chloro-4-aminoquinazoline. Journal of the American Chemical Society, 1948, Volume: 70, Issue:12 Topics: Humans; Quinazolines	1948
Design, synthesis and antitumor activity of 4-aminoquinazoline derivatives targeting VEGFR-2 tyrosine kinase. Bioorganic & medicinal chemistry letters, 2012, Jan-01, Volume: 22, Issue:1 Topics: Animals; Antineoplastic Agents; Chemistry, Pharmaceutical; Drug Design; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Hep G2 Cells; Humans; Inhibitory Concentration 50; Mice; Mice, Nude; Models, Chemical; Neoplasm Transplantation; Piperidines; Quinazolines; Vascular Endothelial Growth Factor Receptor-2	2012
Synthesis and evaluation of novel F-18 labeled 4-aminoquinazoline derivatives: potential PET imaging agents for tumor detection. Bioorganic & medicinal chemistry letters, 2012, Jul-15, Volume: 22, Issue:14 Topics: Animals; Female; Fluorine Radioisotopes; Mice; Molecular Structure; Neoplasm Transplantation; Neoplasms; Organ Specificity; Positron-Emission Tomography; Quinazolines	2012
Synthesis and quantum chemical studies of new 4-aminoquinazoline derivatives as Aurora A/B kinase inhibitors. Chemical biology & drug design, 2013, Volume: 81, Issue:3 Topics: Antineoplastic Agents; Aurora Kinases; Binding Sites; Cell Line, Tumor; Cell Proliferation; HT29 Cells; Humans; K562 Cells; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Quantum Theory; Quinazolines; Structure-Activity Relationship	2013
Discovery, synthesis, and structure-activity relationships of 2-aminoquinazoline derivatives as a novel class of metabotropic glutamate receptor 5 negative allosteric modulators. Bioorganic & medicinal chemistry letters, 2013, Aug-15, Volume: 23, Issue:16 Topics: Allosteric Regulation; Animals; Cells, Cultured; Drug Discovery; Drug Evaluation, Preclinical; Humans; Inhibitory Concentration 50; Models, Molecular; Quinazolines; Quinazolinones; Rats; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Structure-Activity Relationship; Toluidines; User-Computer Interface	2013
Rational design of inhibitors of the bacterial cell wall synthetic enzyme GlmU using virtual screening and lead-hopping. Bioorganic & medicinal chemistry, 2014, Nov-01, Volume: 22, Issue:21 Topics: Animals; Anti-Bacterial Agents; Cell Wall; Drug Design; Enzyme Inhibitors; Escherichia coli; Escherichia coli Infections; Escherichia coli Proteins; Haemophilus Infections; Haemophilus influenzae; Humans; Molecular Docking Simulation; Multienzyme Complexes; Quinazolines	2014
Discovery of 4-aminoquinazoline--urea derivatives as Aurora kinase inhibitors with antiproliferative activity. Bioorganic & medicinal chemistry, 2014, Nov-01, Volume: 22, Issue:21 Topics: Antineoplastic Agents; Aurora Kinase A; Aurora Kinase B; Benzamides; Binding Sites; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Evaluation, Preclinical; Enzyme Activation; Humans; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Quinazolines; Structure-Activity Relationship; Urea	2014
Discovery of substituted 4-aminoquinazolines as selective Toll-like receptor 4 ligands. Bioorganic & medicinal chemistry letters, 2014, Nov-01, Volume: 24, Issue:21 Topics: Animals; High-Throughput Screening Assays; Humans; Immunity, Innate; Interleukin-6; Interleukin-8; Leukocytes, Mononuclear; Ligands; Mice; Models, Molecular; Molecular Structure; NF-kappa B; Quinazolines; Signal Transduction; Structure-Activity Relationship; Toll-Like Receptor 4; Toll-Like Receptors	2014
A mild and regioselective route to functionalized quinazolines. Chemistry (Weinheim an der Bergstrasse, Germany), 2015, Oct-05, Volume: 21, Issue:41 Topics: Amides; Catalysis; Cyclization; Molecular Structure; Quinazolines; Rhodium	2015
Novel 4-aminoquinazoline derivatives as new leads for anticancer drug discovery. Acta pharmaceutica (Zagreb, Croatia), 2015, Volume: 65, Issue:3 Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Doxorubicin; Drug Discovery; Female; Humans; Inhibitory Concentration 50; MCF-7 Cells; Quinazolines; Structure-Activity Relationship; Thiophenes	2015
NAD(P)H: quinone oxidoreductase 1 inducer activity of novel 4-aminoquinazoline derivatives. Journal of enzyme inhibition and medicinal chemistry, 2016, Volume: 31, Issue:6 Topics: Animals; Cell Line; Enzyme Induction; Mice; NAD(P)H Dehydrogenase (Quinone); Quinazolines; Spectrum Analysis	2016
Synthesis and investigation of novel 6-(1,2,3-triazol-4-yl)-4-aminoquinazolin derivatives possessing hydroxamic acid moiety for cancer therapy. Bioorganic & medicinal chemistry, 2017, 01-01, Volume: 25, Issue:1 Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Drug Design; Drug Screening Assays, Antitumor; Green Fluorescent Proteins; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Molecular Docking Simulation; Quinazolines; Receptor, ErbB-2; Structure-Activity Relationship; Triazoles	2017
Structure-Based Design of 6-Chloro-4-aminoquinazoline-2-carboxamide Derivatives as Potent and Selective p21-Activated Kinase 4 (PAK4) Inhibitors. Journal of medicinal chemistry, 2018, 01-11, Volume: 61, Issue:1 Topics: Catalytic Domain; Drug Design; Humans; Models, Molecular; p21-Activated Kinases; Protein Kinase Inhibitors; Quinazolines; Structure-Activity Relationship; Substrate Specificity	2018
Design, synthesis and biological evaluation of novel 4-aminoquinazolines as dual target inhibitors of EGFR-PI3Kα. European journal of medicinal chemistry, 2018, Feb-25, Volume: 146 Topics: Antineoplastic Agents; Cell Proliferation; Cell Survival; Class I Phosphatidylinositol 3-Kinases; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; ErbB Receptors; Humans; Molecular Structure; Protein Kinase Inhibitors; Quinazolines; Structure-Activity Relationship; Tumor Cells, Cultured	2018
Novel 4-aminoquinazoline derivatives induce growth inhibition, cell cycle arrest and apoptosis via PI3Kα inhibition. Bioorganic & medicinal chemistry, 2018, 05-01, Volume: 26, Issue:8 Topics: Antineoplastic Agents; Apoptosis; Cell Cycle Checkpoints; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Quinazolines; Structure-Activity Relationship; Tumor Cells, Cultured	2018
Synthesis and antitumor activity of novel 6,7,8-trimethoxy N-aryl-substituted-4-aminoquinazoline derivatives. Bioorganic & medicinal chemistry letters, 2018, 08-01, Volume: 28, Issue:14 Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Epidermal Growth Factor; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Molecular Structure; Phosphorylation; Protein Kinase Inhibitors; Quinazolines; Structure-Activity Relationship	2018
Structure-based drug design: Synthesis and biological evaluation of quinazolin-4-amine derivatives as selective Aurora A kinase inhibitors. European journal of medicinal chemistry, 2018, Sep-05, Volume: 157 Topics: Aurora Kinase A; Dose-Response Relationship, Drug; Drug Design; Humans; Models, Molecular; Molecular Structure; Protein Kinase Inhibitors; Quinazolines; Structure-Activity Relationship	2018
Benzofuran-appended 4-aminoquinazoline hybrids as epidermal growth factor receptor tyrosine kinase inhibitors: synthesis, biological evaluation and molecular docking studies. Journal of enzyme inhibition and medicinal chemistry, 2018, Volume: 33, Issue:1 Topics: Adenosine Triphosphate; Apoptosis; Benzofurans; Binding Sites; Cell Line, Tumor; Enzyme Inhibitors; ErbB Receptors; Humans; Inhibitory Concentration 50; Molecular Docking Simulation; Phosphorylation; Proton Magnetic Resonance Spectroscopy; Quinazolines; Spectrometry, Mass, Electrospray Ionization; Structure-Activity Relationship	2018
Design, synthesis, and biological evaluation of some novel 4-aminoquinazolines as Pan-PI3K inhibitors. Bioorganic & medicinal chemistry, 2019, 07-01, Volume: 27, Issue:13 Topics: Humans; Molecular Structure; Phosphatidylinositol 3-Kinases; Protein Kinase Inhibitors; Quinazolines	2019
Selective Toll-like receptor 7 agonists with novel chromeno[3,4-d]imidazol-4(1H)-one and 2-(trifluoromethyl)quinoline/ quinazoline-4-amine scaffolds. European journal of medicinal chemistry, 2019, Oct-01, Volume: 179 Topics: Cell Proliferation; Cytokines; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Imidazoles; Molecular Structure; Quinazolines; Quinolines; Structure-Activity Relationship; Toll-Like Receptor 7	2019
Exploring MDR-TB Inhibitory Potential of 4-Aminoquinazolines as Mycobacterium tuberculosis N-Acetylglucosamine-1-Phosphate Uridyltransferase (GlmU Chemistry & biodiversity, 2020, Volume: 17, Issue:8 Topics: Antitubercular Agents; Enzyme Inhibitors; Mycobacterium tuberculosis; Nucleotidyltransferases; Quinazolines; Spectrum Analysis; Tuberculosis, Multidrug-Resistant	2020
A novel 4-aminoquinazoline derivative, DHW-208, suppresses the growth of human breast cancer cells by targeting the PI3K/AKT/mTOR pathway. Cell death & disease, 2020, 06-30, Volume: 11, Issue:6 Topics: Animals; Apoptosis; Breast Neoplasms; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Movement; Cell Proliferation; Female; Humans; Mice, Nude; Neoplasm Invasiveness; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Quinazolines; Signal Transduction; TOR Serine-Threonine Kinases; Xenograft Model Antitumor Assays	2020
Design, synthesis and evaluation of novel ErbB/HDAC multitargeted inhibitors with selectivity in EGFR European journal of medicinal chemistry, 2021, Mar-05, Volume: 213 Topics: Antineoplastic Agents; Cell Line; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; ErbB Receptors; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Molecular Docking Simulation; Molecular Structure; Mutation; Protein Kinase Inhibitors; Quinazolines; Structure-Activity Relationship	2021
One Atom Makes All the Difference: Getting a Foot in the Door between SOS1 and KRAS. Journal of medicinal chemistry, 2021, 05-27, Volume: 64, Issue:10 Topics: Afatinib; Allosteric Regulation; Binding Sites; Catalytic Domain; Colorectal Neoplasms; ErbB Receptors; Humans; Molecular Dynamics Simulation; Mutagenesis, Site-Directed; Protein Interaction Maps; Proto-Oncogene Proteins p21(ras); Quinazolines; SOS1 Protein	2021
Design, Synthesis, and Characterization of 4-Aminoquinazolines as Potent Inhibitors of the G Protein-Coupled Receptor Kinase 6 (GRK6) for the Treatment of Multiple Myeloma. Journal of medicinal chemistry, 2021, 08-12, Volume: 64, Issue:15 Topics: Animals; Antineoplastic Agents; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; G-Protein-Coupled Receptor Kinases; Humans; Mice; Models, Molecular; Molecular Structure; Multiple Myeloma; Protein Kinase Inhibitors; Quinazolines; Structure-Activity Relationship	2021
Discovery of N-(3-bromo-1H-indol-5-yl)-quinazolin-4-amine as an effective molecular skeleton to develop reversible/irreversible pan-HER inhibitors. European journal of medicinal chemistry, 2022, Apr-05, Volume: 233 Topics: Antineoplastic Agents; Cell Line, Tumor; ErbB Receptors; Humans; Molecular Structure; Mutation; Protein Kinase Inhibitors; Quinazolines; Structure-Activity Relationship	2022
Collaborative Virtual Screening Identifies a 2-Aryl-4-aminoquinazoline Series with Efficacy in an Journal of medicinal chemistry, 2023, 01-26, Volume: 66, Issue:2 Topics: Chagas Disease; Humans; Quinazolines; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi	2023