Page last updated: 2024-08-21

quinazolines and 4-(4'-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline

quinazolines has been researched along with 4-(4'-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline in 49 studies

Research

Studies (49)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	5 (10.20)	18.2507
2000's	26 (53.06)	29.6817
2010's	16 (32.65)	24.3611
2020's	2 (4.08)	2.80

Authors

Authors	Studies
Klis, D; Liu, XP; Narla, RK; Uckun, FM	1
Chen, CL; Chen, H; Liu, XP; Malaviya, R; Uckun, FM	1
Ghosh, S; Liu, XP; Mahajan, S; Mao, C; Narla, RK; Sudbeck, EA; Uckun, FM	1
Dibirdik, I; Malaviya, R; Uckun, FM; Zhu, D	1
Chen, CL; Ek, O; Liu, XP; Uckun, FM	1
Liu, R; Liu, XP; Trieu, VN; Uckun, FM	1
Liu, XP; Lorenz, D; Schonhoff, D; Tibbles, HE; Uckun, FM; Vassilev, A; Waurzyniak, B; Wendorf, H; Zhu, D	1
Cetkovic-Cvrlje, M; Liu, XP; Roers, BA; Uckun, FM; Waurzyniak, B	2
Chen, CL; Chen, H; Liu, XP; Malaviya, R; Mao, C; Sudbeck, E; Thoen, J; Uckun, FM	1
Cetkovic-Cvrlje, M; Dragt, AL; Liu, XP; Uckun, FM; Vassilev, A	1
Cetkovic-Cvrlje, M; Dragt, AL; Uckun, FM	1
Bartell, S; Mahajan, S; Tibbles, HE; Uckun, FM; Vassilev, A; Zheng, Y	1
Hall, MW; Hart, J; Kim, HJ; Knatz, N; Wewers, MD	1
Chávez, R; García-Zepeda, E; Licona, I; Ramírez, M; Salgado, A; Soldevila, G	1
Cetkovic-Cvrlje, M; Uckun, FM	1
Briones, J; Ferrer, B; Forné, I; Juarez, C; Martinez-Gallo, M; Martinez-Lostao, L; Rodriguez-Sanchez, JL; Sierra, J	1
Aoyama, S; Hamada, H; Hirasawa, N; Linwong, W; Ohuchi, K; Saito, T	1
Fujii, N; Okabayashi, T; Suzutani, T; Yokosawa, N; Yokota, S	1
Cochet, O; Frelin, C; Imbert, V; Peyron, JF	1
Kasprzycka, M; Marzec, M; Odum, N; Ptasznik, A; Wasik, MA; Wlodarski, P; Zhang, Q	1
Thompson, JE	1
Kumar, N; Mishra, J; Narang, VS; Waters, CM	1
D'Cruz, OJ; Uckun, FM	1
Erbeck, D; Qazi, S; Tibbles, HE; Uckun, FM; Vassilev, A; Venkatachalam, T	1
Ozer, Z; Qazi, S; Tibbles, H; Uckun, FM; Vassilev, A	1
Kankaanranta, H; Kärpänniemi, O; Korhonen, R; Moilanen, E; Nieminen, R; Sareila, O	1
Changelian, PS; Doty, JL; Flanagan, ME; Harris, TM; Kent, CR; Kudlacz, EM; Kuhn, CF; Magnuson, KS; Moshinsky, D; Munchhof, MJ; Perregaux, DG; Sawyer, PS; Sun, J; Whipple, DA	1
Adachi, S; Endo, M; Ito, E; Kanegane, H; Kanezaki, R; Kiyoi, H; Kojima, S; Mano, H; Migita, M; Miura, M; Morinaga, S; Nakano, T; Sato, T; Terui, K; Toki, T; Xu, G	1
Cho, S; Choe, JH; Choi, JH; Kim, JH; Kim, JS; Kim, S; Kim, WW; Lee, JE; Lee, SK; Lim, HI; Nam, SJ; Yang, JH	1
Choi, HN; Kim, EK; Kwon, KB; Lv, N; Moon, WS; Park, BH; Park, JW; Park, SJ; Song, MY	1
Aksenov, ND; Marakhova, II; Mitiushova, EV	1
Amizuka, N; Freitas, PH; Guo, Y; Henderson, JE; Kojima, T; Li, M; Liu, Z; Maeda, T; Nagata, M; Oda, K; Seki, Y; Shimomura, J; Sultana, S; Suzuki, R; Takagi, R; Tamura, M; Ubaidus, S; Yamamoto, T	1
Dibirdik, I; Qazi, S; Uckun, FM; Yiv, S	1
Dibirdik, I; Qazi, S; Uckun, FM	1
Dibirdik, I; Uckun, FM	1
Barata, JT; Batista, A; Cardoso, AA; Carlesso, N; Nadler, LM; Raderschall, E; Sallan, SE	1
Bhavsar, SK; Bobbala, D; Gu, S; Lang, F	1
Aida, Y; Honda, K; Maeno, M; Makimura, M; Matsumura, H; Nakayama, G; Shimizu, O; Suzuki, N; Takeichi, O; Tanigawa, S	1
Jung, YJ; Kang, KP; Kim, DH; Kim, W; Lee, AS; Lee, JE; Lee, S; Lee, SH; Park, BH; Park, SK	1
Cetkovic-Cvrlje, M; Ghate, K; Olson, M	1
Ahn, M; Kim, SH; Koh, HW; Lee, SH; Lee, SM; Oh, YB; Park, BH	1
Aksenov, ND; Marakhova, II; Mitiushova, EV; Shatrova, AN; Zenin, VV	1
Aksenov, NV; Marakhova, LL; Mityushova, EV; Shatrova, AN	1
Bhavsar, SK; Hosseinzadeh, Z; Khairnar, V; Koepsell, H; Lang, F; Lang, KS; Lang, PA; Palmada, M; Sabolic, I; Sharma, P; Singh, Y; Zhang, S	1
Aksenov, ND; Marakhova, II; Mityushova, EV; Nikolsky, NN; Shatrova, AN; Vassilieva, IO; Zenin, VV	1
Chen, SY; Chuang, YH; Cui, XB; Wang, YC	1
Güven, DC; Orhan, C; Şahin, K; Uçkun, FM	1
Chen, H; Liang, D; Pan, L; Peng, Z; Tian, H; Zhang, R	1

Reviews

3 review(s) available for quinazolines and 4-(4'-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline

Article	Year
JAK protein kinase inhibitors. Drug news & perspectives, 2005, Volume: 18, Issue:5 Topics: Animals; Drug Design; Enzyme Inhibitors; Forecasting; Gene Expression Regulation; Humans; Janus Kinase 1; Janus Kinase 2; Janus Kinase 3; Mannich Bases; Piperidines; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Pyrimidines; Pyrroles; Quinazolines; Signal Transduction; TYK2 Kinase	2005
Targeting mast cells in endometriosis with janus kinase 3 inhibitor, JANEX-1. American journal of reproductive immunology (New York, N.Y. : 1989), 2007, Volume: 58, Issue:2 Topics: Endometriosis; Female; Humans; Infertility, Female; Janus Kinase 3; Mast Cells; Quinazolines	2007
Data-Driven identification of chemopreventive agents for breast cancer Turkish journal of medical sciences, 2020, 11-03, Volume: 50, Issue:SI-2 Topics: Amides; Animals; Antineoplastic Agents; Breast Neoplasms; Chemoprevention; Female; Humans; Mammary Neoplasms, Experimental; Mice; Nitriles; Protein Kinase Inhibitors; Quinazolines	2020

Other Studies

46 other study(ies) available for quinazolines and 4-(4'-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline

Article	Year
Inhibition of human glioblastoma cell adhesion and invasion by 4-(4'-hydroxylphenyl)-amino-6,7-dimethoxyquinazoline (WHI-P131) and 4-(3'-bromo-4'-hydroxylphenyl)-amino-6,7-dimethoxyquinazoline (WHI-P154). Clinical cancer research : an official journal of the American Association for Cancer Research, 1998, Volume: 4, Issue:10 Topics: Actins; Antineoplastic Agents; Cell Adhesion; Epidermal Growth Factor; Glioblastoma; Humans; Integrins; Neoplasm Invasiveness; Quinazolines; Tumor Cells, Cultured	1998
Quantitative high-performance liquid chromatographic method for pharmacokinetic studies of the potent mast cell inhibitor 4-(4'-hydroxyphenyl)amino-6,7-dimethoxyquinazoline (WHI-P131). Journal of chromatography. B, Biomedical sciences and applications, 1999, Apr-30, Volume: 727, Issue:1-2 Topics: Animals; Anti-Allergic Agents; Area Under Curve; Cell Line; Chromatography, High Pressure Liquid; Half-Life; Mast Cells; Mice; Mice, Inbred BALB C; Pilot Projects; Quinazolines; Rats; Reproducibility of Results; Sensitivity and Specificity	1999
Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agents. Clinical cancer research : an official journal of the American Association for Cancer Research, 1999, Volume: 5, Issue:6 Topics: Antineoplastic Agents; Apoptosis; Binding Sites; Computer Simulation; Drug Design; Drug Evaluation, Preclinical; Humans; Janus Kinase 1; Janus Kinase 2; Janus Kinase 3; Leukemia; Models, Molecular; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Quinazolines; Substrate Specificity; Tumor Cells, Cultured; Tumor Stem Cell Assay	1999
Targeting Janus kinase 3 in mast cells prevents immediate hypersensitivity reactions and anaphylaxis. The Journal of biological chemistry, 1999, Sep-17, Volume: 274, Issue:38 Topics: Anaphylaxis; Animals; Calcium; Cell Line; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Humans; Hypersensitivity, Immediate; Janus Kinase 3; Male; Mast Cells; Mice; Mice, Inbred BALB C; Protein-Tyrosine Kinases; Quinazolines; Receptors, IgE	1999
In vivo toxicity and pharmacokinetic features of the janus kinase 3 inhibitor WHI-P131 [4-(4'hydroxyphenyl)-amino-6,7- dimethoxyquinazoline. Clinical cancer research : an official journal of the American Association for Cancer Research, 1999, Volume: 5, Issue:10 Topics: Animals; Antineoplastic Agents; Enzyme Inhibitors; Humans; Janus Kinase 3; Macaca fascicularis; Male; Mice; Mice, Inbred BALB C; Protein-Tyrosine Kinases; Quinazolines; Rats; Rats, Inbred Lew; Tissue Distribution; Tumor Cells, Cultured	1999
A specific inhibitor of janus kinase-3 increases survival in a transgenic mouse model of amyotrophic lateral sclerosis. Biochemical and biophysical research communications, 2000, Jan-07, Volume: 267, Issue:1 Topics: Animals; Antioxidants; Disease Models, Animal; Enzyme Inhibitors; Genetic Variation; Genistein; Heterozygote; Humans; Janus Kinase 3; Male; Mice; Mice, Inbred BALB C; Mice, Transgenic; Motor Neuron Disease; Neuroprotective Agents; Paralysis; Protein-Tyrosine Kinases; Quinazolines; Superoxide Dismutase	2000
Role of a JAK3-dependent biochemical signaling pathway in platelet activation and aggregation. The Journal of biological chemistry, 2001, May-25, Volume: 276, Issue:21 Topics: Animals; DNA-Binding Proteins; Humans; Janus Kinase 3; Mice; Mice, Knockout; Platelet Aggregation; Protein-Tyrosine Kinases; Quinazolines; Signal Transduction; STAT1 Transcription Factor; STAT3 Transcription Factor; Trans-Activators	2001
Targeting Janus kinase 3 to attenuate the severity of acute graft-versus-host disease across the major histocompatibility barrier in mice. Blood, 2001, Sep-01, Volume: 98, Issue:5 Topics: Acute Disease; Animals; Bone Marrow Transplantation; Cell Transplantation; Drug Evaluation, Preclinical; Drug Therapy, Combination; Enzyme Inhibitors; Graft vs Host Disease; H-2 Antigens; Immunosuppressive Agents; Janus Kinase 3; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Male; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Phytohemagglutinins; Protein-Tyrosine Kinases; Quinazolines; Radiation Chimera; Signal Transduction; Spleen; T-Lymphocytes, Cytotoxic; Whole-Body Irradiation	2001
CYP1A-mediated metabolism of the Janus kinase-3 inhibitor 4-(4'-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline: structural basis for inactivation by regioselective O-demethylation. Drug metabolism and disposition: the biological fate of chemicals, 2002, Volume: 30, Issue:1 Topics: Animals; Capillary Permeability; Cell Line; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Dogs; Enzyme Inhibitors; Female; Guinea Pigs; Humans; In Vitro Techniques; Janus Kinase 3; Macaca fascicularis; Mast Cells; Mice; Microsomes, Liver; Models, Molecular; Passive Cutaneous Anaphylaxis; Protein Binding; Protein-Tyrosine Kinases; Quinazolines; Rabbits; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Species Specificity; Stereoisomerism	2002
Janus kinase 3 inhibitor WHI-P131/JANEX-1 prevents graft-versus-host disease but spares the graft-versus-leukemia function of the bone marrow allografts in a murine bone marrow transplantation model. Blood, 2002, Jun-01, Volume: 99, Issue:11 Topics: Animals; Bone Marrow Transplantation; Crosses, Genetic; Female; Graft Survival; Graft vs Leukemia Effect; Janus Kinase 3; Major Histocompatibility Complex; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Protein-Tyrosine Kinases; Quinazolines; Transplantation, Homologous; Whole-Body Irradiation	2002
Targeting JAK3 with JANEX-1 for prevention of autoimmune type 1 diabetes in NOD mice. Clinical immunology (Orlando, Fla.), 2003, Volume: 106, Issue:3 Topics: Adoptive Transfer; Animals; Cytokines; Diabetes Mellitus, Type 1; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Interleukin-2; Janus Kinase 3; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Milk Proteins; Ovalbumin; Phosphorylation; Protein-Tyrosine Kinases; Quinazolines; STAT5 Transcription Factor; T-Lymphocytes; Trans-Activators; Tyrosine	2003
Prevention of islet allograft rejection in diabetic mice by targeting Janus Kinase 3 with 4-(4'-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline (JANEX-1). Arzneimittel-Forschung, 2003, Volume: 53, Issue:9 Topics: Animals; Cyclosporine; Diabetes Mellitus, Experimental; Drug Therapy, Combination; Enzyme Inhibitors; Graft Rejection; Immunosuppressive Agents; Islets of Langerhans Transplantation; Janus Kinase 3; Major Histocompatibility Complex; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Protein-Tyrosine Kinases; Quinazolines	2003
The anti-leukemic Bruton's tyrosine kinase inhibitor alpha-cyano-beta-hydroxy-beta-methyl-N-(2,5-dibromophenyl) propenamide (LFM-A13) prevents fatal thromboembolism. Leukemia & lymphoma, 2003, Volume: 44, Issue:9 Topics: Adenosine Diphosphate; Agammaglobulinaemia Tyrosine Kinase; Amides; Animals; Aspirin; Bleeding Time; Catalytic Domain; Collagen; Drug Design; Drug Evaluation, Preclinical; Enzyme Inhibitors; Fibrinolytic Agents; Humans; Janus Kinase 3; Male; Mice; Mice, Inbred ICR; Nitriles; Peptide Fragments; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Protein-Tyrosine Kinases; Pulmonary Embolism; Quinazolines; Receptors, Collagen; Signal Transduction; Thrombin; Thromboembolism; Thromboplastin	2003
Janus kinase 3 down-regulates lipopolysaccharide-induced IL-1 beta-converting enzyme activation by autocrine IL-10. Journal of immunology (Baltimore, Md. : 1950), 2004, Apr-15, Volume: 172, Issue:8 Topics: Animals; Autocrine Communication; Caspase 1; Caspase Inhibitors; Cells, Cultured; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Humans; Inflammation; Interleukin-10; Interleukin-4; Janus Kinase 3; Lipopolysaccharides; Macrophages, Peritoneal; Mice; Mice, Inbred C57BL; Mice, Knockout; Monocytes; Protein-Tyrosine Kinases; Quinazolines; Signal Transduction	2004
Impaired chemokine-induced migration during T-cell development in the absence of Jak 3. Immunology, 2004, Volume: 112, Issue:2 Topics: Animals; Chemokine CXCL12; Chemokines; Chemokines, CC; Chemokines, CXC; Chemotaxis, Leukocyte; Dose-Response Relationship, Immunologic; Hematopoietic Stem Cells; Janus Kinase 3; Mice; Mice, Inbred C57BL; Mice, Knockout; Phosphorylation; Protein-Tyrosine Kinases; Quinazolines; Receptors, CCR; Receptors, Chemokine; Receptors, CXCR4; T-Lymphocytes; Thymus Gland; Tyrosine	2004
Dual targeting of Bruton's tyrosine kinase and Janus kinase 3 with rationally designed inhibitors prevents graft-versus-host disease (GVHD) in a murine allogeneic bone marrow transplantation model. British journal of haematology, 2004, Volume: 126, Issue:6 Topics: Acute Disease; Agammaglobulinaemia Tyrosine Kinase; Amides; Animals; Bone Marrow Transplantation; Drug Therapy, Combination; Enzyme Inhibitors; Graft vs Host Disease; Immunosuppressive Agents; Janus Kinase 3; Male; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Nitriles; Protein-Tyrosine Kinases; Quinazolines; Survival Rate; Treatment Outcome	2004
Role of the STAT1 pathway in apoptosis induced by fludarabine and JAK kinase inhibitors in B-cell chronic lymphocytic leukemia. Leukemia & lymphoma, 2005, Volume: 46, Issue:3 Topics: Aged; Aged, 80 and over; Apoptosis; Cell Survival; DNA-Binding Proteins; Electrophoretic Mobility Shift Assay; Female; Flow Cytometry; Humans; Interferon-gamma; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Protein-Tyrosine Kinases; Quinazolines; Signal Transduction; STAT1 Transcription Factor; Time Factors; Trans-Activators; Tumor Cells, Cultured; Tyrphostins; Vidarabine	2005
Inhibition of the antigen-induced activation of rodent mast cells by putative Janus kinase 3 inhibitors WHI-P131 and WHI-P154 in a Janus kinase 3-independent manner. British journal of pharmacology, 2005, Volume: 145, Issue:6 Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Cycle Proteins; Cell Degranulation; Cell Line, Tumor; Dinitrophenols; Hexosaminidases; Immunoglobulin E; Janus Kinase 3; Mast Cells; Mice; Mice, Knockout; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-fyn; Proto-Oncogene Proteins c-vav; Quinazolines; Rats; Serum Albumin; src-Family Kinases	2005
Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 confers efficient viral replication. Virology, 2005, Jul-20, Volume: 338, Issue:1 Topics: Amnion; Base Sequence; Cell Line; DNA-Binding Proteins; Enzyme Inhibitors; Female; Herpesvirus 1, Human; Humans; Janus Kinase 3; Oligodeoxyribonucleotides, Antisense; Pregnancy; Protein-Tyrosine Kinases; Quinazolines; Repressor Proteins; Signal Transduction; STAT3 Transcription Factor; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins; T-Lymphocytes; Trans-Activators; Transcription Factors; Transfection; U937 Cells; Virus Replication	2005
Constitutive activation of STAT proteins in the HDLM-2 and L540 Hodgkin lymphoma-derived cell lines supports cell survival. Cellular signalling, 2006, Volume: 18, Issue:4 Topics: Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Cell Survival; Electrophoretic Mobility Shift Assay; Hodgkin Disease; Humans; Immunoprecipitation; Quinazolines; RNA, Small Interfering; Signal Transduction; STAT Transcription Factors; Tumor Cells, Cultured; Tyrphostins	2006
Inhibition of ALK enzymatic activity in T-cell lymphoma cells induces apoptosis and suppresses proliferation and STAT3 phosphorylation independently of Jak3. Laboratory investigation; a journal of technical methods and pathology, 2005, Volume: 85, Issue:12 Topics: Anaplastic Lymphoma Kinase; Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Janus Kinase 3; Lymphoma, T-Cell; Phosphorylation; Protein-Tyrosine Kinases; Quinazolines; Receptor Protein-Tyrosine Kinases; STAT3 Transcription Factor	2005
Janus kinase 3 regulates interleukin 2-induced mucosal wound repair through tyrosine phosphorylation of villin. The Journal of biological chemistry, 2007, Oct-19, Volume: 282, Issue:42 Topics: Actins; Animals; Caco-2 Cells; Cell Movement; Cytoskeleton; Dose-Response Relationship, Drug; Enterocytes; Enzyme Activation; Hematopoietic Stem Cells; Humans; Interleukin-2; Intestinal Mucosa; Janus Kinase 3; Mice; Microfilament Proteins; Phosphorylation; Protein Processing, Post-Translational; Protein Transport; Quinazolines; Tyrosine; Wound Healing	2007
Effect of targeting janus kinase 3 on the development of intestinal tumors in the adenomatous polyposis coli(min) mouse model of familial adenomatous polyposis. Arzneimittel-Forschung, 2007, Volume: 57, Issue:6 Topics: Adenomatous Polyposis Coli; Animals; beta Catenin; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Intestinal Neoplasms; Janus Kinase 3; Male; Mice; Mice, Inbred C57BL; Point Mutation; Quinazolines; Survival Analysis; Tissue Distribution	2007
Anti-inflammatory activity profile of JANEX-1 in preclinical animal models. Bioorganic & medicinal chemistry, 2008, Feb-01, Volume: 16, Issue:3 Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Cell Line; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Hindlimb; Humans; Janus Kinase 3; Lipopolysaccharides; Macrophages; Mice; Nitric Oxide; Quinazolines; Signal Transduction; Systemic Inflammatory Response Syndrome; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha	2008
Janus kinase 3 inhibitor WHI-P154 in macrophages activated by bacterial endotoxin: differential effects on the expression of iNOS, COX-2 and TNF-alpha. International immunopharmacology, 2008, Volume: 8, Issue:1 Topics: Cell Line; Cyclooxygenase 2; Down-Regulation; Humans; Interferon-gamma; Janus Kinase 3; Lipopolysaccharides; Macrophage Activation; Macrophages; Nitric Oxide; Nitric Oxide Synthase Type II; Protein Kinase Inhibitors; Quinazolines; STAT1 Transcription Factor; Tumor Necrosis Factor-alpha	2008
The specificity of JAK3 kinase inhibitors. Blood, 2008, Feb-15, Volume: 111, Issue:4 Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Enzyme Inhibitors; Graft Rejection; Humans; Janus Kinase 3; Kinetics; Protein-Tyrosine Kinases; Pyrimidines; Pyrroles; Quinazolines	2008
Functional analysis of JAK3 mutations in transient myeloproliferative disorder and acute megakaryoblastic leukaemia accompanying Down syndrome. British journal of haematology, 2008, Volume: 141, Issue:5 Topics: Base Sequence; Cell Proliferation; Dose-Response Relationship, Drug; Down Syndrome; Female; Humans; Janus Kinase 3; Leukemia, Megakaryoblastic, Acute; Male; Molecular Sequence Data; Mutation; Myeloproliferative Disorders; Neoplasm Proteins; Quinazolines; Signal Transduction; Tumor Cells, Cultured	2008
EGF-induced MMP-9 expression is mediated by the JAK3/ERK pathway, but not by the JAK3/STAT-3 pathway in a SKBR3 breast cancer cell line. Cellular signalling, 2009, Volume: 21, Issue:6 Topics: Breast Neoplasms; Cell Line, Tumor; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Janus Kinase 1; Janus Kinase 2; Janus Kinase 3; Matrix Metalloproteinase 9; Phosphorylation; Quinazolines; RNA, Messenger; RNA, Small Interfering; STAT3 Transcription Factor; Tyrphostins	2009
JANEX-1, a JAK3 inhibitor, protects pancreatic islets from cytokine toxicity through downregulation of NF-kappaB activation and the JAK/STAT pathway. Experimental cell research, 2009, Jul-15, Volume: 315, Issue:12 Topics: Animals; Cell Survival; Cells, Cultured; Down-Regulation; Insulin-Secreting Cells; Interferon-gamma; Interleukin-1beta; Janus Kinase 3; Male; Mice; NF-kappa B; Nitric Oxide Synthase Type II; Phosphorylation; Quinazolines; Rats; Rats, Sprague-Dawley; Signal Transduction; STAT Transcription Factors; Suppressor of Cytokine Signaling 1 Protein; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins	2009
[Specific function of STAT5 in regulation of proliferation of chronic leukemia K562 cells: inhibitory effect of WHI-P131]. Tsitologiia, 2010, Volume: 52, Issue:2 Topics: Cell Division; Cell Proliferation; Humans; Interphase; K562 Cells; Lymphocytes; Phosphorylation; Quinazolines; STAT5 Transcription Factor	2010
FGFR3 down-regulates PTH/PTHrP receptor gene expression by mediating JAK/STAT signaling in chondrocytic cell line. Journal of electron microscopy, 2010, Volume: 59, Issue:3 Topics: Animals; Cell Line; Cell Proliferation; Chondrocytes; Down-Regulation; Hedgehog Proteins; Janus Kinases; Parathyroid Hormone; Parathyroid Hormone-Related Protein; Quinazolines; Rats; Receptor, Fibroblast Growth Factor, Type 3; Receptor, Parathyroid Hormone, Type 1; Signal Transduction; STAT Transcription Factors; Transfection	2010
Therapeutic nanoparticle constructs of a JAK3 tyrosine kinase inhibitor against human B-lineage ALL cells. Arzneimittel-Forschung, 2010, Volume: 60, Issue:4 Topics: Animals; Antineoplastic Agents; Apoptosis; Calibration; Cell Lineage; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Female; Humans; Janus Kinase 3; Leukemia, B-Cell; Leukemia, Biphenotypic, Acute; Liposomes; Mice; Mice, SCID; Nanoparticles; Osmolar Concentration; Particle Size; Protein Kinase Inhibitors; Quinazolines	2010
Prevention of UVB-induced skin inflammation, genotoxicity, and photocarcinogenesis in mice by WHI-P131, a dual-function inhibitor of Janus kinase 3 and EGF receptor kinase. Arzneimittel-Forschung, 2010, Volume: 60, Issue:4 Topics: Administration, Topical; Animals; Antimutagenic Agents; Dermatitis; ErbB Receptors; Female; Janus Kinase 3; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mutagenicity Tests; Neoplasms, Radiation-Induced; Protein Kinase Inhibitors; Quinazolines; Radiation Injuries, Experimental; Skin Neoplasms; Ultraviolet Rays	2010
Chemoprevention of colorectal cancer by targeting Janus kinase 3 with a rationally designed small molecule inhibitor. Nutrition and cancer, 2010, Volume: 62, Issue:7 Topics: Animals; Anticarcinogenic Agents; Colorectal Neoplasms; Janus Kinase 3; Mice; Mice, Inbred C57BL; Protein Kinase Inhibitors; Quinazolines	2010
Targeting of active mTOR inhibits primary leukemia T cells and synergizes with cytotoxic drugs and signaling inhibitors. Experimental hematology, 2011, Volume: 39, Issue:4 Topics: Antibiotics, Antineoplastic; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chromones; Dexamethasone; Doxorubicin; Drug Synergism; Enzyme Inhibitors; Eukaryotic Initiation Factor-4G; Humans; Immunoblotting; Immunohistochemistry; Janus Kinase 3; Microscopy, Fluorescence; Morpholines; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Proto-Oncogene Proteins c-akt; Quinazolines; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases	2011
Janus kinase 3 is expressed in erythrocytes, phosphorylated upon energy depletion and involved in the regulation of suicidal erythrocyte death. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2011, Volume: 27, Issue:5 Topics: Adenosine Triphosphate; Animals; Annexin A5; Cell Death; Cell Size; Erythrocyte Count; Erythrocytes; Female; Flow Cytometry; Gene Deletion; Glucose; Humans; Immunohistochemistry; Janus Kinase 3; Male; Mice; Mice, Knockout; Microscopy, Confocal; Phosphatidylserines; Phosphorylation; Protein Kinase Inhibitors; Quinazolines	2011
IL-6 and soluble IL-6 receptor stimulate the production of MMPs and their inhibitors via JAK-STAT and ERK-MAPK signalling in human chondrocytes. Cell biology international, 2012, Apr-01, Volume: 36, Issue:4 Topics: Cartilage; Chondrocytes; Flavonoids; Gene Expression Regulation; Humans; Interleukin-6; Janus Kinase 3; Matrix Metalloproteinases; Mitogen-Activated Protein Kinases; Plasminogen Activator Inhibitor 1; Primary Cell Culture; Protein Kinase Inhibitors; Quinazolines; Receptors, Interleukin-6; Signal Transduction; Solubility; Tissue Inhibitor of Metalloproteinases; Urokinase-Type Plasminogen Activator	2012
Janex-1, a JAK3 inhibitor, ameliorates tumor necrosis factor-α-induced expression of cell adhesion molecules and improves myocardial vascular permeability in endotoxemic mice. International journal of molecular medicine, 2012, Volume: 29, Issue:5 Topics: Animals; Capillary Permeability; Cell Adhesion Molecules; Chemokine CX3CL1; Coronary Vessels; Endotoxemia; Heart; Human Umbilical Vein Endothelial Cells; Humans; Intercellular Adhesion Molecule-1; Janus Kinase 3; Male; Mice; Mice, Inbred C57BL; Quinazolines; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1	2012
Targeting Janus tyrosine kinase 3 (JAK3) with an inhibitor induces secretion of TGF-β by CD4+ T cells. Cellular & molecular immunology, 2012, Volume: 9, Issue:4 Topics: Animals; Apoptosis; CD4 Lymphocyte Count; Cells, Cultured; Cytoprotection; Diabetes Mellitus, Type 1; Female; Humans; Janus Kinase 3; Mice; Mice, Inbred NOD; Quinazolines; T-Lymphocytes, Regulatory; Transforming Growth Factor beta; Up-Regulation	2012
Inhibition of Janus activated kinase-3 protects against myocardial ischemia and reperfusion injury in mice. Experimental & molecular medicine, 2013, May-17, Volume: 45 Topics: Animals; Apoptosis; Cell Movement; Chemokines; Heart Function Tests; Inflammation; Janus Kinase 3; Macrophages; Male; Mice; Mice, Inbred C57BL; Myocardial Reperfusion Injury; Myocardium; Myocytes, Cardiac; Neutrophils; Quinazolines	2013
[The STAT5 signaling in the expression of alpha-subunit of interleukin-2 receptor in human blood lymphocytes]. Tsitologiia, 2013, Volume: 55, Issue:6 Topics: Cell Proliferation; Cells, Cultured; Gene Expression Regulation; Humans; Interleukin Receptor Common gamma Subunit; Interleukin-2; Interleukin-2 Receptor alpha Subunit; Interleukin-2 Receptor beta Subunit; Janus Kinase 3; Lymphocytes; Phosphorylation; Phytohemagglutinins; Protein Kinase Inhibitors; Quinazolines; Signal Transduction; STAT3 Transcription Factor; STAT5 Transcription Factor	2013
[THE INDUCTION OF CD25 EXPRESSION IN Jurkat T CELLS]. Tsitologiia, 2015, Volume: 57, Issue:5 Topics: Cell Cycle Checkpoints; Cell Proliferation; Gene Expression Regulation; Humans; Interleukin-2; Interleukin-2 Receptor alpha Subunit; Janus Kinases; Jurkat Cells; Lymphocyte Count; Phorbol 12,13-Dibutyrate; Phytohemagglutinins; Protein Kinase Inhibitors; Quinazolines; Signal Transduction; STAT Transcription Factors	2015
Expression of JAK3 Sensitive Na+ Coupled Glucose Carrier SGLT1 in Activated Cytotoxic T Lymphocytes. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2016, Volume: 39, Issue:3 Topics: 4-Chloro-7-nitrobenzofurazan; Animals; Biological Transport; Brefeldin A; Caco-2 Cells; Deoxyglucose; Gene Expression Regulation; Glucose; Humans; Janus Kinase 3; Jurkat Cells; Lymphocyte Activation; Mice; Oocytes; Patch-Clamp Techniques; Phlorhizin; Primary Cell Culture; Quinazolines; Signal Transduction; Sodium-Glucose Transporter 1; Spleen; T-Lymphocytes, Cytotoxic; Transgenes; Xenopus laevis	2016
Time-Dependent Regulation of IL-2R α-Chain (CD25) Expression by TCR Signal Strength and IL-2-Induced STAT5 Signaling in Activated Human Blood T Lymphocytes. PloS one, 2016, Volume: 11, Issue:12 Topics: Blotting, Western; Cell Cycle; Cell Proliferation; Cells, Cultured; Gene Expression Regulation; Humans; Interleukin-2; Interleukin-2 Receptor alpha Subunit; Janus Kinase 3; Lymphocyte Activation; Phosphorylation; Phytohemagglutinins; Quinazolines; Receptors, Antigen, T-Cell; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; STAT5 Transcription Factor; T-Lymphocytes; Time Factors	2016
Janus Kinase 3, a Novel Regulator for Smooth Muscle Proliferation and Vascular Remodeling. Arteriosclerosis, thrombosis, and vascular biology, 2017, Volume: 37, Issue:7 Topics: Animals; Apoptosis; Becaplermin; Carotid Arteries; Carotid Artery Injuries; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Janus Kinase 3; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Neointima; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-sis; Quinazolines; Rats; RNA Interference; Signal Transduction; STAT3 Transcription Factor; Time Factors; Transfection; Vascular Remodeling	2017
JANEX-1 improves acute pulmonary embolism through VEGF and FAK in pulmonary artery smooth muscle cells. Experimental biology and medicine (Maywood, N.J.), 2020, Volume: 245, Issue:15 Topics: Acute Disease; Animals; Cell Proliferation; Disease Models, Animal; Focal Adhesion Protein-Tyrosine Kinases; Janus Kinase 3; Lung; Male; Mice, Inbred C57BL; Myocytes, Smooth Muscle; Phosphorylation; Platelet-Derived Growth Factor; Pulmonary Artery; Pulmonary Embolism; Quinazolines; STAT3 Transcription Factor; Vascular Endothelial Growth Factor A; Vascular Remodeling	2020