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quinazolines and 2,4-diaminoquinazoline

quinazolines has been researched along with 2,4-diaminoquinazoline in 46 studies

Research

Studies (46)

Timeframe	Studies, this research(%)	All Research%
pre-1990	6 (13.04)	18.7374
1990's	8 (17.39)	18.2507
2000's	6 (13.04)	29.6817
2010's	21 (45.65)	24.3611
2020's	5 (10.87)	2.80

Authors

Authors	Studies
Fukunaga, JY; Hansch, C; Steller, EE	1
Bowden, K; Harris, NV; Smith, C	1
Berman, JD; Edwards, N; King, M	1
Freisheim, JH; Hynes, JB; Kumar, A; Susten, SS	1
Cheng, CC; Roth, B	1
Bird, K; Hunt, WE; Mallinson, PD; Schwalbe, CH	1
McCormack, JJ	1
Blurton, P; Brown, TH; Ife, RJ; Keeling, DJ; Leach, CA; Meeson, ML; Parsons, ME; Theobald, CJ	1
Baccanari, DP; Boytos, CM; Chan, JH; Hong, JS; Joyner, SS; Kuyper, LF; Rudolph, SK; Tansik, RL	1
Clancy, J; Manousos, M; McGuirk, PR; Petitpas, J; Subashi, T; Tait-Kamradt, A; Watts, P; Wondrack, L	1
Bertino, JR; Ercikan-Abali, E; Mota, CE; Queener, SF; Rosowsky, A; Waltham, M	1
Beverley, SM; Hardy, LW; Matthews, W; Nare, B	1
Aqvist, J; Graffner-Nordberg, M; Hallberg, A; Hansson, T; Marelius, J	1
Cui, M; Czarnik, AW; Heldsinger, A; Lemrow, SM; Loo, JA; Mei, HY; Sannes-Lowery, KA; Sharmeen, L	1
Wilson, LJ	1
Chen, H; Rosowsky, A	1
Kokwaro, G; Marsh, K; Mberu, E; Nduati, E; Nzila, A; Ommeh, S; Rosowsky, A	1
Hattori, K; Igarashi, S; Ishikawa, N; Kawano, N; Matsumoto, Y; Miyazaki, T; Ogino, S; Ohta, M; Takeuchi, M; Yokoyama, K	1
Hattori, K; Igarashi, S; Ishikawa, N; Kawano, N; Masuda, N; Matsumoto, Y; Miyazaki, T; Ogino, S; Ohta, M; Orita, M; Takeuchi, M; Yokoyama, K	1
Adair, OO; Gangjee, A; Pagley, M; Queener, SF	1
Andrésson, T; Burghes, AH; Butchbach, ME; Edwards, JD; Gurney, ME; Jarecki, J; Pellizzoni, L; Saieva, L; Simard, LR; Singh, J; Slominski, E; Thorsteinsdóttir, M; Thurmond, J; Zhang, J	1
Huang, C; Lin, J; Yan, SJ; Yan, YY; Zheng, H	1
Cho, YS; Doddareddy, MR; Hahn, JS; Hong, TJ; Pae, AN; Seo, SH; Thorat, DA	1
Font, M; González, Á; Palop, JA; Sanmartín, C	1
Brown-Driver, V; Chen, Z; Creighton, C; Cunningham, M; Finn, J; G C, K; Hilgers, M; Kohnen, L; Kwan, B; Lam, T; Li, X; Nelson, K; Shaw, KJ; Stidham, M; Trzoss, M; Zhang, J	1
Chen, Y; Deng, Y; Deng, YX; He, L; Liu, N; Yin, P	1
Ausubel, FM; Conery, AL; Feinbaum, R; Kirienko, NV; Larkins-Ford, J; Pukkila-Worley, R	1
Cao, SL; Gao, RT; Han, Y; Li, ZF; Liao, J; Mao, BB; Wang, Y; Xiahou, ZK; Xu, X; Yuan, CZ; Zhao, BL	1
Benitez, JA; Silva, AJ; Wang, H; Zhang, L	1
He, PL; Hu, YH; Jing, JF; Li, YC; Tang, W; Tong, XK; Yu, Y; Zuo, JP	1
Alling, T; Bailey, MA; Cramer, JW; Dalai, S; Early, J; Hipskind, PA; Ioerger, T; Kesicki, EA; Kumar, N; O'Malley, T; Odingo, J; Ollinger, J; Parish, T; Sacchettini, J; Singh, RV; Vickers, R	1
Geoghegan, KF; Gopalsamy, A; Hett, EC; Johnson, DS; Jones, LH; Kyne, RE; Menard, CA; Narayanan, A; Parikh, MD; Robinson, RP; Tones, MA; Xu, H	1
Froeyen, M; Kaptein, S; Neyts, J; Rozenski, J; Saudi, M; Van Aerschot, A; Venkatesham, A	1
Cherry, JJ; Fadeyi, O; Foley, TL; Gopalsamy, A; Jones, LH; Kyne, RE; LaRosa, G; Liu, S; Loria, PM; Maglich-Goodwin, J; Menard, C; Nabhan, JF; Narayanan, A; Noell, S; Parikh, MD; Petersen, DN; Ren, Y; Rong, H; Tones, MA	1
Chen, M; Cheng, M; Guo, J; Hao, C; Huang, W; Jiang, X; Li, F; Li, X; Song, S; Wang, J; Wang, K; Yan, Z; Zhao, D	1
Chen, X; Liu, Y; Qi, C; Yang, P; Zhang, J	1
Butchbach, MER; Connell, AJ; Gentillon, C; Kirk, RW	1
Androphy, EJ; Calo, A; Cherry, JJ; Custer, SK; DiDonato, CJ; Du, S; Foley, TL; Gopalsamy, A; Gordo, SM; Gordon, W; Hosea, N; Jones, LH; Krizay, DK; LaRosa, G; Li, H; Mathur, S; Menard, CA; Patel, P; Potter, K; Ramos-Zayas, R; Reedich, EJ; Rietz, A; Rong, H; Tones, MA; Zhang, B	1
Cheng, M; Guo, J; Hao, C; Pang, Y; Wang, J; Wang, K; Wu, T; Yin, W; Zhao, D; Zhu, M	1
Amssoms, K; De Pooter, D; Dhuyvetter, D; Embrechts, W; Fanning, G; Herschke, F; Horton, H; Jonckers, THM; Last, S; McGowan, D; Mostmans, W; Pande, V; Pauwels, F; Pieters, S; Pille, G; Raboisson, P; Scholliers, A; Smyej, I; Stoops, B; Thone, T; Van Dijck, K; Van Schoubroeck, B	1
Bonnett, SA; Melief, E; Parish, T; Zuniga, ES	1
Aguayo-Ortiz, R; Dominguez, L; Hernández-Luis, F; Herrera-Vázquez, FS; Matadamas-Martínez, F; Ramírez-Apan, T; Yépez-Mulia, L	1
Chan, MWY; Chang, TS; Chen, WM; Chiang, MK; Hsieh, YY; Lu, CK; Tung, SY; Wei, KL; Wu, CS	1
An, T; Han, SB; Jeong, EJ; Kim, H; Kim, M; Noh, K; Shin, JS	1
Bishop, OT; Boyom, FF; Dize, D; Duffy, J; Fokou, PVT; Keumoe, R; Kouipou Toghueo, RM; Laleu, B; Njanpa, CN; Tata, RB; Tchatat, MB; Tchuenguia, VC; Yamthe, LT	1
Acharya, BN; Dash, PK; Parida, M; Rajaiya, J; Saha, A; Saxena, N	1

Reviews

2 review(s) available for quinazolines and 2,4-diaminoquinazoline

Article	Year
Recent progress in the medicinal chemistry of 2,4-diaminopyrimidines. Progress in medicinal chemistry, 1982, Volume: 19 Topics: Amino Acid Sequence; Animals; Folic Acid Antagonists; Glutamates; Glutamic Acid; Malaria; Mathematics; Methotrexate; Microbial Sensitivity Tests; Models, Chemical; Pyrimethamine; Pyrimidines; Quinazolines; Stereoisomerism; Triazines	1982
Dihydrofolate reductase inhibitors as potential drugs. Medicinal research reviews, 1981,Fall, Volume: 1, Issue:3 Topics: Aminopterin; Animals; Antimalarials; Bacterial Infections; Biological Transport; Drug Interactions; Folic Acid; Folic Acid Antagonists; Helminthiasis; Humans; Immunosuppressive Agents; Leukemia, Experimental; Liver; Methotrexate; Mice; Mycoses; Neoplasms; Protozoan Infections; Psoriasis; Quinazolines; Rats; Receptors, Drug; Trypanosoma cruzi	1981

Article

Year

Recent progress in the medicinal chemistry of 2,4-diaminopyrimidines.

Progress in medicinal chemistry, 1982, Volume: 19

Topics: Amino Acid Sequence; Animals; Folic Acid Antagonists; Glutamates; Glutamic Acid; Malaria; Mathematics; Methotrexate; Microbial Sensitivity Tests; Models, Chemical; Pyrimethamine; Pyrimidines; Quinazolines; Stereoisomerism; Triazines

1982

Dihydrofolate reductase inhibitors as potential drugs.

Medicinal research reviews, 1981,Fall, Volume: 1, Issue:3

Topics: Aminopterin; Animals; Antimalarials; Bacterial Infections; Biological Transport; Drug Interactions; Folic Acid; Folic Acid Antagonists; Helminthiasis; Humans; Immunosuppressive Agents; Leukemia, Experimental; Liver; Methotrexate; Mice; Mycoses; Neoplasms; Protozoan Infections; Psoriasis; Quinazolines; Rats; Receptors, Drug; Trypanosoma cruzi

1981

Other Studies

44 other study(ies) available for quinazolines and 2,4-diaminoquinazoline

Article	Year
Inhibition of dihydrofolate reductase. Structure-activity correlations of quinazolines. Journal of medicinal chemistry, 1976, Volume: 19, Issue:5 Topics: Binding Sites; Folic Acid Antagonists; Liver; Molecular Conformation; Quinazolines; Structure-Activity Relationship	1976
Antifolate and antibacterial activities of 5-substituted 2,4-diaminoquinazolines. Journal of medicinal chemistry, 1990, Volume: 33, Issue:1 Topics: Animals; Anti-Bacterial Agents; Cattle; Chemical Phenomena; Chemistry; Escherichia coli; Escherichia coli Infections; Folic Acid Antagonists; Liver; Mice; Molecular Structure; Quinazolines; Staphylococcus aureus; Structure-Activity Relationship	1990
Antileishmanial activities of 2,4-diaminoquinazoline putative dihydrofolate reductase inhibitors. Antimicrobial agents and chemotherapy, 1989, Volume: 33, Issue:11 Topics: Animals; Folic Acid Antagonists; Humans; In Vitro Techniques; Leishmania tropica; Monocytes; Quinazolines	1989
Inhibition of dihydrofolate reductase, methotrexate transport, and growth of methotrexate-sensitive and -resistant L1210 leukemia cells in vitro by 5-substituted 2,4-diaminoquinazolines. Biochemical pharmacology, 1985, Jun-15, Volume: 34, Issue:12 Topics: Animals; Biological Transport; Cells, Cultured; Drug Resistance; Folic Acid Antagonists; Leukemia L1210; Methotrexate; Mice; Quinazolines; Structure-Activity Relationship	1985
Crystallographic and molecular-orbital studies on the geometry of antifolate drugs. The Biochemical journal, 1980, May-01, Volume: 187, Issue:2 Topics: Chemical Phenomena; Chemistry; Crystallography; Folic Acid Antagonists; Proguanil; Pyrimidines; Quinazolines; Triazines	1980
Reversible inhibitors of the gastric (H+/K+)-ATPase. 5. Substituted 2,4-diaminoquinazolines and thienopyrimidines. Journal of medicinal chemistry, 1995, Jul-07, Volume: 38, Issue:14 Topics: Animals; Dogs; Magnetic Resonance Spectroscopy; Proton Pump Inhibitors; Pyrimidines; Quinazolines; Rats; Stomach; Structure-Activity Relationship	1995
Selective inhibitors of Candida albicans dihydrofolate reductase: activity and selectivity of 5-(arylthio)-2,4-diaminoquinazolines. Journal of medicinal chemistry, 1995, Sep-01, Volume: 38, Issue:18 Topics: Animals; Antifungal Agents; Candida albicans; Drug Design; Folic Acid Antagonists; Humans; Mice; Pyrimethamine; Pyrimidines; Quinazolines; Recombinant Proteins; Structure-Activity Relationship; Trimethoprim; Trimetrexate	1995
Assays to detect and characterize human immunodeficiency virus type 1 (HIV-1) receptor antagonists, compounds that inhibit binding of the HIV-1 surface glycoprotein, gp120, to the CD4 receptor on human T lymphocytes. Antimicrobial agents and chemotherapy, 1994, Volume: 38, Issue:9 Topics: Antibodies, Monoclonal; Antibody Specificity; Antiviral Agents; CD4 Antigens; CD4-Positive T-Lymphocytes; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique; HIV Envelope Protein gp120; HIV-1; Humans; Protein Binding; Quinazolines; Receptors, HIV	1994
2,4-Diamino-5-substituted-quinazolines as inhibitors of a human dihydrofolate reductase with a site-directed mutation at position 22 and of the dihydrofolate reductases from Pneumocystis carinii and Toxoplasma gondii. Journal of medicinal chemistry, 1995, Mar-03, Volume: 38, Issue:5 Topics: Animals; Folic Acid Antagonists; Humans; In Vitro Techniques; Liver; Mutagenesis, Site-Directed; Pneumocystis; Quinazolines; Rats; Structure-Activity Relationship; Toxoplasma	1995
Biochemical and genetic tests for inhibitors of Leishmania pteridine pathways. Experimental parasitology, 1997, Volume: 87, Issue:3 Topics: Animals; Cell Division; Drug Resistance; Folic Acid Antagonists; Humans; Leishmania; Methotrexate; Microbial Sensitivity Tests; Multienzyme Complexes; Mutation; Oxidoreductases; Pteridines; Pyrimidines; Quinazolines; Species Specificity; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase	1997
Computation of affinity and selectivity: binding of 2,4-diaminopteridine and 2,4-diaminoquinazoline inhibitors to dihydrofolate reductases. Journal of computer-aided molecular design, 1998, Volume: 12, Issue:2 Topics: Computer Simulation; Drug Design; Folic Acid Antagonists; Humans; Mathematical Computing; Models, Molecular; Protein Binding; Pteridines; Quinazolines; Substrate Specificity; Tetrahydrofolate Dehydrogenase	1998
Inhibitors of protein-RNA complexation that target the RNA: specific recognition of human immunodeficiency virus type 1 TAR RNA by small organic molecules. Biochemistry, 1998, Oct-06, Volume: 37, Issue:40 Topics: Allosteric Regulation; Aminoglycosides; Anti-Bacterial Agents; Anti-HIV Agents; Binding, Competitive; Down-Regulation; Drug Design; Gene Products, tat; HIV Long Terminal Repeat; HIV-1; Humans; Quinazolines; Quinoxalines; RNA-Binding Proteins; RNA, Viral; tat Gene Products, Human Immunodeficiency Virus; Transcriptional Activation; Virus Replication	1998
Traceless solid-phase synthesis of 2,4-diaminoquinazolines. Organic letters, 2001, Feb-22, Volume: 3, Issue:4 Topics: Adrenergic alpha-Antagonists; Amines; Cyclization; Isothiocyanates; Nitriles; Prazosin; Quinazolines; Resins, Plant	2001
A novel method of synthesis of 2,4-diamino-6-arylmethylquinazolines using palladium(0)-catalyzed organozinc chemistry. The Journal of organic chemistry, 2001, Nov-02, Volume: 66, Issue:22 Topics: Catalysis; Enzyme Inhibitors; Folic Acid Antagonists; Palladium; Pyrimidines; Quinazolines; Zinc	2001
In vitro activities of 2,4-diaminoquinazoline and 2,4-diaminopteridine derivatives against Plasmodium falciparum. Antimicrobial agents and chemotherapy, 2004, Volume: 48, Issue:10 Topics: Animals; Antimalarials; Dapsone; Dihydropteroate Synthase; Drug Resistance; Folic Acid Antagonists; Plasmodium falciparum; Pteridines; Quinazolines; Saccharomyces cerevisiae; Tetrahydrofolate Dehydrogenase	2004
Discovery of potent CCR4 antagonists: Synthesis and structure-activity relationship study of 2,4-diaminoquinazolines. Bioorganic & medicinal chemistry, 2008, Jul-15, Volume: 16, Issue:14 Topics: Animals; Chemotaxis; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Mice; Quinazolines; Receptors, CCR4; Structure-Activity Relationship	2008
Potent CCR4 antagonists: synthesis, evaluation, and docking study of 2,4-diaminoquinazolines. Bioorganic & medicinal chemistry, 2008, Sep-01, Volume: 16, Issue:17 Topics: Animals; Binding Sites; Cell Line; Computer Simulation; Drug Evaluation, Preclinical; Humans; Injections, Subcutaneous; Mice; Models, Chemical; Models, Molecular; Molecular Structure; Oxazolone; Quinazolines; Receptors, CCR4; Skin Diseases; Stereoisomerism; Structure-Activity Relationship	2008
N9-substituted 2,4-diaminoquinazolines: synthesis and biological evaluation of lipophilic inhibitors of pneumocystis carinii and toxoplasma gondii dihydrofolate reductase. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Animals; Binding Sites; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enzyme Inhibitors; Liver; Molecular Structure; Pneumocystis carinii; Quinazolines; Rats; Stereoisomerism; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Toxoplasma	2008
Effects of 2,4-diaminoquinazoline derivatives on SMN expression and phenotype in a mouse model for spinal muscular atrophy. Human molecular genetics, 2010, Feb-01, Volume: 19, Issue:3 Topics: Animals; Cell Survival; Disease Models, Animal; Gene Expression; Humans; Mice; Mice, Knockout; Mice, Transgenic; Motor Neurons; Muscular Atrophy, Spinal; Phenotype; Promoter Regions, Genetic; Quinazolines; Survival of Motor Neuron 2 Protein	2010
Synthesis of highly functionalized 2,4-diaminoquinazolines as anticancer and anti-HIV agents. Bioorganic & medicinal chemistry letters, 2010, Aug-01, Volume: 20, Issue:15 Topics: Anti-HIV Agents; Antineoplastic Agents; Cell Line, Tumor; Crystallography, X-Ray; Drug Screening Assays, Antitumor; Humans; Molecular Conformation; Neoplasms; Quinazolines; Structure-Activity Relationship	2010
Synthesis and biological evaluation of 2,4-diaminoquinazoline derivatives as novel heat shock protein 90 inhibitors. Bioorganic & medicinal chemistry letters, 2011, Mar-15, Volume: 21, Issue:6 Topics: Cell Line, Tumor; Cell Proliferation; Drug Evaluation, Preclinical; HSP90 Heat-Shock Proteins; Humans; Quinazolines	2011
New insights into the structural requirements for pro-apoptotic agents based on 2,4-diaminoquinazoline, 2,4-diaminopyrido[2,3-d]pyrimidine and 2,4-diaminopyrimidine derivatives. European journal of medicinal chemistry, 2011, Volume: 46, Issue:9 Topics: Apoptosis; Crystallography, X-Ray; Hydrogen Bonding; Models, Molecular; Molecular Structure; Pyridines; Pyrimidines; Quinazolines	2011
Structure-based design of new DHFR-based antibacterial agents: 7-aryl-2,4-diaminoquinazolines. Bioorganic & medicinal chemistry letters, 2011, Sep-15, Volume: 21, Issue:18 Topics: Anti-Bacterial Agents; Crystallography, X-Ray; Dose-Response Relationship, Drug; Drug Design; Enzyme Inhibitors; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Quinazolines; Staphylococcus aureus; Stereoisomerism; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase	2011
Synthesis of 2,4-diaminoquinazolines and tricyclic quinazolines by cascade reductive cyclization of methyl N-cyano-2-nitrobenzimidates. The Journal of organic chemistry, 2012, Mar-16, Volume: 77, Issue:6 Topics: Antidepressive Agents, Tricyclic; Cyclization; Imidoesters; Molecular Structure; Quinazolines	2012
Stimulation of host immune defenses by a small molecule protects C. elegans from bacterial infection. PLoS genetics, 2012, Volume: 8, Issue:6 Topics: Activating Transcription Factors; Animals; Anti-Bacterial Agents; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Gene Expression Regulation; Host-Pathogen Interactions; Immunity, Innate; MAP Kinase Signaling System; Oligonucleotide Array Sequence Analysis; p38 Mitogen-Activated Protein Kinases; Pseudomonas aeruginosa; Pseudomonas Infections; Quinazolines; RNA Interference; Small Molecule Libraries	2012
Synthesis and antiproliferative activity of 4-substituted-piperazine-1-carbodithioate derivatives of 2,4-diaminoquinazoline. European journal of medicinal chemistry, 2013, Volume: 64 Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; HCT116 Cells; HeLa Cells; HT29 Cells; Humans; MCF-7 Cells; Molecular Structure; Piperazines; Quinazolines; Structure-Activity Relationship; Thiocarbamates	2013
A quinazoline-2,4-diamino analog suppresses Vibrio cholerae flagellar motility by interacting with motor protein PomB and induces envelope stress. Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:8 Topics: Adhesins, Bacterial; Amino Acid Substitution; Bacterial Proteins; Cell Membrane; Cholera Toxin; DNA-Directed RNA Polymerases; Flagella; Genes, Bacterial; Protein Folding; Protein Interaction Mapping; Quinazolines; Sodium Channels; Stress, Physiological; Transcription, Genetic; Vibrio cholerae	2013
Discovering novel anti-HCV compounds with inhibitory activities toward HCV NS3/4A protease. Acta pharmacologica Sinica, 2014, Volume: 35, Issue:8 Topics: Amides; Antiviral Agents; Cell Line; Drug Evaluation, Preclinical; Hepacivirus; Hepatitis C; Humans; Quinazolines; Viral Nonstructural Proteins	2014
Synthesis and evaluation of the 2,4-diaminoquinazoline series as anti-tubercular agents. Bioorganic & medicinal chemistry, 2014, Dec-15, Volume: 22, Issue:24 Topics: Animals; Antitubercular Agents; Drug Resistance, Bacterial; Half-Life; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Quinazolines; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship	2014
A library approach to rapidly discover photoaffinity probes of the mRNA decapping scavenger enzyme DcpS. Molecular bioSystems, 2015, Volume: 11, Issue:10 Topics: Binding Sites; Endoribonucleases; Gene Library; Humans; Models, Molecular; Molecular Probes; Photoaffinity Labels; Quinazolines	2015
Aminopurine and aminoquinazoline scaffolds for development of potential dengue virus inhibitors. European journal of medicinal chemistry, 2017, Jan-27, Volume: 126 Topics: 2-Aminopurine; Antiviral Agents; Dengue Virus; Drug Design; Molecular Docking Simulation; Protein Conformation; Quinazolines; Viral Nonstructural Proteins	2017
Design of Potent mRNA Decapping Scavenger Enzyme (DcpS) Inhibitors with Improved Physicochemical Properties To Investigate the Mechanism of Therapeutic Benefit in Spinal Muscular Atrophy (SMA). Journal of medicinal chemistry, 2017, 04-13, Volume: 60, Issue:7 Topics: Animals; Disease Models, Animal; Drug Design; Endoribonucleases; Enzyme Inhibitors; HEK293 Cells; Humans; Mice; Molecular Docking Simulation; Muscular Atrophy, Spinal; Quinazolines; RNA, Messenger; Survival of Motor Neuron 2 Protein	2017
Development of 2, 4-diaminoquinazoline derivatives as potent PAK4 inhibitors by the core refinement strategy. European journal of medicinal chemistry, 2017, May-05, Volume: 131 Topics: A549 Cells; Cell Cycle; Cell Movement; Dose-Response Relationship, Drug; Humans; Molecular Docking Simulation; Molecular Structure; p21-Activated Kinases; Protein Kinase Inhibitors; Quinazolines; Structure-Activity Relationship	2017
Activation of Wnt3α/β-catenin signal pathway attenuates apoptosis of the cerebral microvascular endothelial cells induced by oxygen-glucose deprivation. Biochemical and biophysical research communications, 2017, 08-19, Volume: 490, Issue:2 Topics: Animals; Apoptosis; beta Catenin; Cell Survival; Cells, Cultured; Cerebrovascular Circulation; Cerebrum; Endothelial Cells; Glucose; Hypoxia; Intercellular Signaling Peptides and Proteins; Lithium Chloride; Microvessels; Oxygen; Quinazolines; Rats; Rats, Sprague-Dawley; Wnt Signaling Pathway; Wnt3 Protein	2017
The effects of C5-substituted 2,4-diaminoquinazolines on selected transcript expression in spinal muscular atrophy cells. PloS one, 2017, Volume: 12, Issue:6 Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Cells, Cultured; Humans; Mice; Muscular Atrophy, Spinal; Quinazolines; RNA, Messenger; Survival of Motor Neuron 2 Protein; Transcription, Genetic	2017
In vitro and in vivo effects of 2,4 diaminoquinazoline inhibitors of the decapping scavenger enzyme DcpS: Context-specific modulation of SMN transcript levels. PloS one, 2017, Volume: 12, Issue:9 Topics: Animals; Cell Line; Disease Models, Animal; Endoribonucleases; Enzyme Inhibitors; Female; Gene Knockdown Techniques; HEK293 Cells; Humans; Male; Mice; Mice, Knockout; Muscular Atrophy, Spinal; Promoter Regions, Genetic; Quinazolines; RNA, Messenger; Survival of Motor Neuron 2 Protein	2017
Discovery of 2-(4-Substituted-piperidin/piperazine-1-yl)-N-(5-cyclopropyl-1H-pyrazol-3-yl)-quinazoline-2,4-diamines as PAK4 Inhibitors with Potent A549 Cell Proliferation, Migration, and Invasion Inhibition Activity. Molecules (Basel, Switzerland), 2018, Feb-14, Volume: 23, Issue:2 Topics: A549 Cells; Cell Movement; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Lung Neoplasms; Neoplasm Invasiveness; p21-Activated Kinases; Quinazolines	2018
2,4-Diaminoquinazolines as Dual Toll-like Receptor (TLR) 7/8 Modulators for the Treatment of Hepatitis B Virus. Journal of medicinal chemistry, 2018, 07-26, Volume: 61, Issue:14 Topics: Animals; Antiviral Agents; HEK293 Cells; Hepatitis B virus; Humans; Male; Mice; Molecular Docking Simulation; Protein Conformation; Quinazolines; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Toll-Like Receptor 7; Toll-Like Receptor 8	2018
Activation of 2,4-Diaminoquinazoline in Antimicrobial agents and chemotherapy, 2019, Volume: 63, Issue:1 Topics: Antitubercular Agents; Dioxygenases; Humans; Mixed Function Oxygenases; Mycobacterium tuberculosis; Quinazolines; Structure-Activity Relationship; Transcription Factors	2019
Design, Synthesis and Evaluation of 2,4-Diaminoquinazoline Derivatives as Potential Tubulin Polymerization Inhibitors. ChemMedChem, 2020, 10-05, Volume: 15, Issue:19 Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Molecular Structure; Polymerization; Quinazolines; Structure-Activity Relationship; Tubulin; Tubulin Modulators	2020
2,4-Diamino-Quinazoline, a Wnt Signaling Inhibitor, Suppresses Gastric Cancer Progression and Metastasis. International journal of molecular sciences, 2020, Aug-17, Volume: 21, Issue:16 Topics: Aged; Animals; Antineoplastic Agents; Apoptosis; Axin Protein; Cell Line; Cell Line, Tumor; Cells, Cultured; Female; Humans; Lymphoid Enhancer-Binding Factor 1; Male; Mice; Mice, Nude; Middle Aged; Neoplasm Metastasis; Proto-Oncogene Proteins c-myc; Quinazolines; Receptors, G-Protein-Coupled; Stomach Neoplasms; Wnt Signaling Pathway	2020
The efficacy of a 2,4-diaminoquinazoline compound as an intranasal vaccine adjuvant to protect against influenza A virus infection in vivo. Journal of microbiology (Seoul, Korea), 2022, Volume: 60, Issue:5 Topics: Adjuvants, Immunologic; Adjuvants, Vaccine; Administration, Intranasal; Animals; Antibodies, Viral; Humans; Immunity, Mucosal; Influenza A virus; Influenza Vaccines; Influenza, Human; Mice; Mice, Inbred BALB C; Orthomyxoviridae Infections; Quinazolines; Toll-Like Receptor 7	2022
Preliminary Structure-Activity Relationship Study of the MMV Pathogen Box Compound MMV675968 (2,4-Diaminoquinazoline) Unveils Novel Inhibitors of Molecules (Basel, Switzerland), 2022, Oct-04, Volume: 27, Issue:19 Topics: Animals; Humans; Iron; Ligands; Quinazolines; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Trypanocidal Agents; Trypanosoma; Trypanosoma brucei brucei; Trypanosomiasis, African	2022
Identification of 2,4-Diaminoquinazoline Derivative as a Potential Small-Molecule Inhibitor against Chikungunya and Ross River Viruses. Viruses, 2023, Oct-31, Volume: 15, Issue:11 Topics: Antiviral Agents; Cell Line; Chikungunya Fever; Chikungunya virus; Humans; Quinazolines; Ross River virus; Virus Replication	2023