quinazolines has been researched along with 2'-deoxyuridylic acid in 31 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (6.45) | 18.7374 |
| 1990's | 19 (61.29) | 18.2507 |
| 2000's | 6 (19.35) | 29.6817 |
| 2010's | 4 (12.90) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Finer-Moore, JS; Kamb, A; Stroud, RM | 1 |
| Calvert, AH; Finer-Moore, J; Kamb, A; Stroud, RM | 1 |
| Fauman, EB; Finer-Moore, JS; Hardy, L; Maley, F; Maley, GF; Montfort, WR; Perry, KM; Stroud, RM | 1 |
| Finer-Moore, JS; Montfort, WR; Stroud, RM | 1 |
| Garvey, EP; Santi, DV | 1 |
| Danenberg, PV; Pogolotti, AL; Santi, DV | 1 |
| Aherne, GW; Boyle, FT; Brown, M; Gibson, W; Hardcastle, A; Jackman, AL; Kelland, LR; Kimbell, R | 1 |
| Erlichman, C; Mandelbaum, S; Mitrovski, B; Pressacco, J | 1 |
| Connick, TJ; Dunlap, RB; Ellis, PD; Reilly, RT | 1 |
| Dallas, WS; Dev, IK; Ferone, R; Hanlon, M; McKee, DD; Yates, BB | 1 |
| Aherne, W; Boyle, FT; Hardcastle, A; Jackman, AL; Kimbell, R | 1 |
| Birdsall, DL; Finer-Moore, J; Stroud, RM | 1 |
| Aherne, GW; Hardcastle, A; Jackman, AL; Raynaud, F | 1 |
| Stout, TJ; Stroud, RM | 1 |
| Rutenber, EE; Sage, CR; Stout, TJ; Stroud, RM | 1 |
| Appleman, JR; Spencer, HT; Villafranca, JE | 1 |
| Changchien, L; Maley, F; Montfort, WR; Strop, P | 1 |
| Birdsall, DL; Finer-Moore, J; Huang, W; Santi, DV; Stroud, RM | 1 |
| Sage, CR; Stout, TJ; Stroud, RM | 1 |
| Ciesla, J; Dzik, JM; Hardy, LW; Maley, F; Maley, GF; Montfort, WR; Rode, W; Sotelo-Mundo, RR | 1 |
| Anderson, AC; DeLano, WL; O'Neil, RH; Stroud, RM | 1 |
| Berger, FG; Fantz, C; Forsthoefel, A; Jennings, W; Kitchens, M; Lebioda, L; Minor, W; Phan, J; Shaw, D; Spencer, HT | 1 |
| Anderson, AC; Freymann, DM; Perry, KM; Stroud, RM | 1 |
| Almog, R; Maley, F; Maley, GF; Van Roey, P; Waddling, CA | 1 |
| Berger, SH; Dunlap, RB; Koli, S; Lebioda, L; Minor, W; Phan, J | 1 |
| Finer-Moore, JS; Fritz, TA; Liu, L; Stroud, RM | 1 |
| Aispuro-Hernandez, E; Arvizu-Flores, AA; Garcia-Orozco, KD; Maley, F; Rojo-Domínguez, A; Sotelo-Mundo, RR; Valenzuela-Soto, E; Varela-Romero, A; Velazquez-Contreras, EF; Yepiz-Plascencia, G | 1 |
| Berger, SH; Johnson, SR; Lebioda, L; Luo, B; Repalli, J; Yousef, AM | 1 |
| Jarmuła, A; Rode, W | 1 |
| Dong, Y; Guan, Z; Niu, B; Wang, J; Wang, X; Xu, L; Zhang, J; Zhang, T | 1 |
| Chen, D; Jansson, A; Larsson, A; Nordlund, P; Sim, D | 1 |
31 other study(ies) available for quinazolines and 2'-deoxyuridylic acid
| Article | Year |
|---|---|
Cofactor triggers the conformational change in thymidylate synthase: implications for an ordered binding mechanism.
Topics: Binding Sites; Crystallization; Deoxyuracil Nucleotides; Escherichia coli; Folic Acid; Models, Molecular; Molecular Structure; Polyglutamic Acid; Protein Conformation; Quinazolines; Thymidylate Synthase; X-Ray Diffraction | 1992 |
Structural basis for recognition of polyglutamyl folates by thymidylate synthase.
Topics: Amino Acid Sequence; Animals; Binding Sites; Chemical Phenomena; Chemistry, Physical; Crystallization; Deoxyuracil Nucleotides; Electrochemistry; Escherichia coli; Folic Acid; Humans; Kinetics; Mice; Models, Molecular; Molecular Sequence Data; Molecular Structure; Protein Conformation; Quinazolines; Sequence Homology, Amino Acid; Structure-Activity Relationship; Thymidylate Synthase; X-Ray Diffraction | 1992 |
Structure, multiple site binding, and segmental accommodation in thymidylate synthase on binding dUMP and an anti-folate.
Topics: Binding Sites; Crystallization; Deoxyuracil Nucleotides; Escherichia coli; Folic Acid; Folic Acid Antagonists; Models, Molecular; Molecular Conformation; Quinazolines; Thymidylate Synthase | 1990 |
Pairwise specificity and sequential binding in enzyme catalysis: thymidylate synthase.
Topics: Binding Sites; Deoxyuracil Nucleotides; Escherichia coli; Folic Acid; Models, Chemical; Models, Molecular; Molecular Conformation; Quinazolines; Stereoisomerism; Substrate Specificity; Thymidylate Synthase | 1990 |
A stable binary complex between Leishmania major thymidylate synthase and the substrate deoxyuridylate. A slow-binding interaction.
Topics: Animals; Binding, Competitive; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Folic Acid; Kinetics; Leishmania tropica; Quinazolines; Thymidine Monophosphate; Thymidylate Synthase | 1987 |
Kinetics and mechanism of interaction of 10-propargyl-5,8-dideazafolate with thymidylate synthase.
Topics: Antineoplastic Agents; Carbon Radioisotopes; Deoxyuracil Nucleotides; Folic Acid; Kinetics; Leukemia, Experimental; Protein Denaturation; Quinazolines; Spectrophotometry, Ultraviolet; Thymidylate Synthase; Tritium | 1986 |
Mechanisms of acquired resistance to the quinazoline thymidylate synthase inhibitor ZD1694 (Tomudex) in one mouse and three human cell lines.
Topics: Animals; Antineoplastic Agents; Carrier Proteins; Deoxyuracil Nucleotides; Drug Resistance; Female; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Humans; Kinetics; Leukemia L1210; Lymphocytes; Methotrexate; Mice; Neoplasm Proteins; Ovarian Neoplasms; Peptide Synthases; Polyglutamic Acid; Proteins; Quinazolines; Receptors, Cell Surface; Thiophenes; Thymidylate Synthase; Thymine Nucleotides; Tumor Cells, Cultured | 1995 |
Biochemical effects of folate-based inhibitors of thymidylate synthase in MGH-U1 cells.
Topics: Cell Survival; Deoxyuracil Nucleotides; Deoxyuridine; Folic Acid; Folic Acid Antagonists; Glutamates; Humans; In Vitro Techniques; Indoles; Isoindoles; Quinazolines; Structure-Activity Relationship; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 1994 |
Phosphorus-31 nuclear magnetic resonance studies of complexes of thymidylate synthase.
Topics: Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Folic Acid; Magnetic Resonance Spectroscopy; Phosphorus Isotopes; Quinazolines; Tetrahydrofolates; Thymidine Monophosphate; Thymidylate Synthase | 1994 |
Mode of binding of folate analogs to thymidylate synthase. Evidence for two asymmetric but interactive substrate binding sites.
Topics: Binding Sites; Carbon Radioisotopes; Deoxyuracil Nucleotides; Folic Acid; Folic Acid Antagonists; Humans; Indoles; Isoindoles; Kinetics; Macromolecular Substances; Mathematics; Protein Binding; Quinazolines; Structure-Activity Relationship; Thymidylate Synthase | 1994 |
The duration of the inhibition of thymidylate synthase in intact L1210 cells exposed to two different classes of quinazoline analogues.
Topics: Animals; Antineoplastic Agents; Cell Division; Deoxyuracil Nucleotides; Drug Screening Assays, Antitumor; Folic Acid; Folic Acid Antagonists; Leukemia L1210; Mice; Quinazolines; Structure-Activity Relationship; Thiophenes; Thymidylate Synthase; Thymine Nucleotides | 1993 |
Entropy in bi-substrate enzymes: proposed role of an alternate site in chaperoning substrate into, and products out of, thymidylate synthase.
Topics: Binding Sites; Crystallography, X-Ray; Deoxyuracil Nucleotides; Folic Acid; Lacticaseibacillus casei; Models, Molecular; Protein Conformation; Quinazolines; Tetrahydrofolates; Thermodynamics; Thymidylate Synthase | 1996 |
Immunoreactive dUMP and TTP pools as an index of thymidylate synthase inhibition; effect of tomudex (ZD1694) and a nonpolyglutamated quinazoline antifolate (CB30900) in L1210 mouse leukaemia cells.
Topics: Animals; Deoxyuracil Nucleotides; Dipeptides; Dose-Response Relationship, Drug; Folic Acid Antagonists; Leukemia, Experimental; Mice; Mice, Inbred Strains; Quinazolines; Radioimmunoassay; Thiophenes; Thymidylate Synthase; Thymine Nucleotides; Tumor Cells, Cultured | 1996 |
The complex of the anti-cancer therapeutic, BW1843U89, with thymidylate synthase at 2.0 A resolution: implications for a new mode of inhibition.
Topics: Antineoplastic Agents; Binding Sites; Binding, Competitive; Crystallography, X-Ray; Deoxyuracil Nucleotides; Drug Design; Enzyme Inhibitors; Escherichia coli; Folic Acid Antagonists; Indoles; Isoindoles; Models, Molecular; Molecular Structure; Protein Binding; Protein Conformation; Quinazolines; Thymidylate Synthase | 1996 |
An essential role for water in an enzyme reaction mechanism: the crystal structure of the thymidylate synthase mutant E58Q.
Topics: Amino Acid Sequence; Binding Sites; Crystallization; Crystallography, X-Ray; Deoxyuracil Nucleotides; Enzyme Inhibitors; Escherichia coli; Folic Acid; Glutamic Acid; Hydrogen Bonding; Models, Molecular; Mutagenesis, Site-Directed; Point Mutation; Protein Conformation; Quinazolines; Recombinant Proteins; Thymidylate Synthase; Water | 1996 |
Kinetic scheme for thymidylate synthase from Escherichia coli: determination from measurements of ligand binding, primary and secondary isotope effects, and pre-steady-state catalysis.
Topics: Catalysis; Deoxyuracil Nucleotides; Escherichia coli; Folic Acid; Folic Acid Antagonists; Kinetics; Ligands; Molecular Structure; Mutagenesis, Site-Directed; Protein Binding; Protein Conformation; Quinazolines; Spectrometry, Fluorescence; Spectrophotometry; Tetrahydrofolates; Thermodynamics; Thymidine Monophosphate; Thymidylate Synthase | 1997 |
Crystal structures of a marginally active thymidylate synthase mutant, Arg 126-->Glu.
Topics: Antineoplastic Agents; Arginine; Binding Sites; Catalysis; Crystallization; Crystallography, X-Ray; Deoxyuracil Nucleotides; Dimerization; Folic Acid; Folic Acid Antagonists; Glutamic Acid; Hydrogen Bonding; Kinetics; Models, Molecular; Molecular Structure; Mutation; Phosphates; Quinazolines; Thymidylate Synthase | 1997 |
The separate effects of E60Q in Lactobacillus casei thymidylate synthase delineate between mechanisms for formation of intermediates in catalysis.
Topics: Amino Acid Substitution; Asparagine; Binding Sites; Catalysis; Crystallography, X-Ray; Deoxyuracil Nucleotides; Folic Acid; Glutamic Acid; Glutamine; Lacticaseibacillus casei; Mutation; Nucleotides; Protein Binding; Protein Conformation; Pyrimidines; Quinazolines; Structure-Activity Relationship; Substrate Specificity; Thymidylate Synthase | 1998 |
The additivity of substrate fragments in enzyme-ligand binding.
Topics: Crystallography, X-Ray; Deoxyuracil Nucleotides; Deoxyuridine; Escherichia coli; Folic Acid; Models, Molecular; Mutagenesis, Site-Directed; Phosphates; Protein Conformation; Quinazolines; Recombinant Proteins; Ribose; Structure-Activity Relationship; Thymidylate Synthase; Uridine | 1998 |
Crystal structures of rat thymidylate synthase inhibited by Tomudex, a potent anticancer drug.
Topics: Animals; Antimetabolites, Antineoplastic; Bacterial Proteins; Carcinoma, Hepatocellular; Computer Simulation; Crystallography, X-Ray; Deoxyuracil Nucleotides; Humans; Ligands; Models, Molecular; Protein Conformation; Quinazolines; Rats; Recombinant Proteins; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 1999 |
The structural mechanism for half-the-sites reactivity in an enzyme, thymidylate synthase, involves a relay of changes between subunits.
Topics: Binding Sites; Crystallography, X-Ray; Deoxyuracil Nucleotides; Dimerization; Enzyme Activation; Enzyme Inhibitors; Folic Acid; Ligands; Models, Molecular; Peptide Fragments; Pneumocystis; Protein Conformation; Quinazolines; Solutions; Spectrometry, Fluorescence; Thymidylate Synthase | 1999 |
Drug-resistant variants of Escherichia coli thymidylate synthase: effects of substitutions at Pro-254.
Topics: Amino Acid Substitution; Crystallography, X-Ray; Deoxyuracil Nucleotides; Drug Resistance; Drug Resistance, Microbial; Enzyme Inhibitors; Escherichia coli; Fluorodeoxyuridylate; Folic Acid Antagonists; Humans; Kinetics; Mutation; Proline; Protein Conformation; Quinazolines; Tetrahydrofolates; Thymidylate Synthase; Transfection | 2000 |
The crystal structure of thymidylate synthase from Pneumocystis carinii reveals a fungal insert important for drug design.
Topics: Amino Acid Sequence; Binding Sites; Crystallography, X-Ray; Deoxyuracil Nucleotides; Dimerization; Drug Design; Enzyme Inhibitors; Folic Acid; Humans; Hydrogen Bonding; Models, Molecular; Molecular Sequence Data; Mutagenesis, Insertional; Pneumocystis; Protein Binding; Protein Conformation; Quinazolines; Sequence Alignment; Species Specificity; Substrate Specificity; Thymidylate Synthase | 2000 |
Crystal structure of a deletion mutant of human thymidylate synthase Delta (7-29) and its ternary complex with Tomudex and dUMP.
Topics: Binding Sites; Catalytic Domain; Crystallography, X-Ray; Cysteine; Deoxyuracil Nucleotides; Drug Design; Enzyme Inhibitors; Escherichia coli; Humans; Models, Molecular; Protein Binding; Protein Structure, Secondary; Quinazolines; Sequence Deletion; Structure-Activity Relationship; Thiophenes; Thymidylate Synthase | 2001 |
Human thymidylate synthase is in the closed conformation when complexed with dUMP and raltitrexed, an antifolate drug.
Topics: Binding Sites; Computer Simulation; Crystallization; Crystallography, X-Ray; Deoxyuracil Nucleotides; Dimerization; Enzyme Inhibitors; Folic Acid Antagonists; Humans; Ligands; Macromolecular Substances; Models, Molecular; Protein Conformation; Quinazolines; Thiophenes; Thymidylate Synthase | 2001 |
Tryptophan 80 and leucine 143 are critical for the hydride transfer step of thymidylate synthase by controlling active site access.
Topics: Binding Sites; Biological Transport; Deoxyuracil Nucleotides; Escherichia coli; Folic Acid; Leucine; Models, Chemical; Point Mutation; Protons; Quinazolines; Tetrahydrofolates; Thymidylate Synthase; Tryptophan | 2002 |
Functional identity of the active sites of crustacean and viral thymidylate synthases.
Topics: Amino Acid Sequence; Animals; Base Sequence; Catalytic Domain; Cloning, Molecular; Deoxyuracil Nucleotides; Folic Acid; Folic Acid Antagonists; Isoindoles; Kinetics; Models, Molecular; Molecular Sequence Data; Penaeidae; Phylogeny; Quinazolines; Sequence Alignment; Thymidylate Synthase; White spot syndrome virus 1 | 2009 |
Human thymidylate synthase with loop 181-197 stabilized in an inactive conformation: ligand interactions, phosphorylation, and inhibition profiles.
Topics: Amino Acid Motifs; Casein Kinase II; Circular Dichroism; Deoxyuracil Nucleotides; Diphosphonates; Humans; Ligands; Mutation; Phosphorylation; Protein Binding; Protein Structure, Secondary; Quinazolines; Structure-Activity Relationship; Thiophenes; Thymidylate Synthase | 2011 |
Computational study of the effects of protein tyrosine nitrations on the catalytic activity of human thymidylate synthase.
Topics: Deoxyuracil Nucleotides; Humans; Models, Molecular; Molecular Dynamics Simulation; Protein Processing, Post-Translational; Quinazolines; Thiophenes; Thymidylate Synthase; Tyrosine | 2013 |
Raltitrexed's effect on the development of neural tube defects in mice is associated with DNA damage, apoptosis, and proliferation.
Topics: Animals; Apoptosis; Blotting, Western; Cell Proliferation; Deoxyuracil Nucleotides; DNA Damage; Embryo, Mammalian; Female; Folic Acid Antagonists; Gestational Age; Histones; Injections, Intraperitoneal; Male; Mice, Inbred C57BL; Neural Tube Defects; Phosphorylation; Pregnancy; Protein Subunits; Quinazolines; Replication Protein A; Thiophenes; Thymidine Monophosphate; Thymidylate Synthase | 2015 |
Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states.
Topics: Allosteric Site; Amino Acid Substitution; Binding Sites; Catalytic Domain; Crystallography, X-Ray; Deoxyuracil Nucleotides; Dimerization; Enzyme Activation; Enzyme Stability; Folic Acid Antagonists; Humans; Ligands; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Peptide Fragments; Protein Conformation; Protein Folding; Quinazolines; Recombinant Proteins; Thiophenes; Thymidylate Synthase | 2017 |