quinazolines has been researched along with 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one in 95 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (2.11) | 18.2507 |
| 2000's | 51 (53.68) | 29.6817 |
| 2010's | 42 (44.21) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Allal, C; Asslan, R; Favre, G; Le Gaillard, F; Pradines, A; Pratx, C | 1 |
| Gillham, H; Golding, MC; Gullick, WJ; Pepperkok, R | 1 |
| Brattain, MG; Jackson, JG; Koterba, AP; Kreisberg, JI; Yee, D | 1 |
| Balmain, A; Beug, H; Oft, M; Petritsch, C | 1 |
| Conway, A; Pyne, NJ; Pyne, S | 1 |
| Huggett, TM; Jost, M; Kari, C; Rodeck, U | 1 |
| Pouysségur, J; Viñals, F | 1 |
| Chen, K; Keaney, JF; Thomas, SR | 1 |
| Bakanauskas, VJ; Bernhard, EJ; Cerniglia, GJ; Feldman, MD; Goldsmith, JD; Gupta, AK; Machtay, M; McKenna, WG; Mick, R; Muschel, RJ; Rosenthal, DI; Weber, CN; Weber, RS | 1 |
| Barrie, E; Kelland, LR; Rowlands, MG; Smith, V; Workman, P | 1 |
| Conzen, SD; Coticchia, CM; Dickson, RB; Nishanian, TG; Ramljak, D; Ringel, MD; Saji, M | 1 |
| Dick, K; Sadhu, C; Staunton, DE; Tino, WT | 1 |
| Fisher, GJ; Franke, TF; He, T; Quan, T; Voorhees, JJ; Wang, HQ | 1 |
| Basso, A; Moasser, MM; She, QB; Solit, D | 1 |
| Hayflick, JS; Northcott, CA; Watts, SW | 1 |
| Caplin, M; Friedmann, B; Hartley, JA; Hochhauser, D | 1 |
| Kolachana, P; Lawsin, LM; Moore, J; Perlman, A; Ringel, MD; Saji, M | 1 |
| Bernd, A; Guschel, M; Kaufmann, R; Kippenberger, S; Knies, Y; Loitsch, S; Müller, J | 1 |
| Chen, L; Gao, P; Ma, D; Oppenheim, JJ; Sun, R; Wang, J; Zhang, N | 1 |
| Chan, CT; Kane, SE; Metz, MZ | 1 |
| Civiello, G; Janne, PA; Johnson, BE; Mukohara, T | 1 |
| Hayflick, J; Northcott, CA; Watts, SW | 1 |
| Angelucci, A; Biordi, L; Bologna, M; Dolo, V; Festuccia, C; Gravina, GL; Millimaggi, D; Muzi, P; Speca, S; Vicentini, C | 1 |
| Deres, P; Gallyas, F; Hideg, K; Kalai, T; Kovacs, K; Sumegi, B; Toth, A | 1 |
| Gallo, RM; Gilmore, JL; Riese, DJ | 1 |
| Bolotin, D; Chu, DH; Fuchs, E; Polak, L; Wang, X; Williams, T | 1 |
| Chayama, K; Kuwahara, K; Miyata, H; Sasaki, T; Serikawa, M | 1 |
| Aneja, R; Dong, JT; Gao, J; Giannis, A; Joshi, HC; Liu, C; Liu, M; Sarli, V; Sun, L; Wang, H; Zhou, J | 1 |
| Di, W; Healey, S; Kouttab, N; Qiu, L; Sun, Y; Wan, Y; Wanebo, H; Yan, B; Zhou, C | 1 |
| Hayakawa, M; Kaizawa, H; Koizumi, T; Moritomo, H; Ohishi, T; Ohta, M; Okada, M; Parker, P; Tsukamoto, S; Waterfield, M; Workman, P | 1 |
| Ferreira, AM; Hayflick, JS; Isaacs, H; Rogers, KA; Sandig, M | 1 |
| Bi, Z; Li, Y; Wan, Y; Yan, B | 1 |
| Birukov, KG; Garcia, JG; Hassoun, PM; Papaiahgari, S; Reddy, SP; Yerrapureddy, A | 1 |
| Chopp, M; Hong, X; Jiang, F; Kalkanis, SN; Katakowski, M; Yang, H; Zhang, X; Zhang, ZG; Zheng, X | 1 |
| Daubert, RA; Schnellmann, RG; Yan, Y; Zhuang, S | 1 |
| Abad, PC; Chandramouly, G; Knowles, DW; Lelièvre, SA | 1 |
| Carmona-Cuenca, I; Del Castillo, G; Fabregat, I; Fernández, M; Murillo, MM; Ortiz, C; Roncero, C; Sánchez, A | 1 |
| Choi, YH; Kim, GY; Kim, MO; Lee, JD; Lee, MK; Moon, DO | 1 |
| Bae, YS; Catt, KJ; Choi, H; Hunyady, L; Leto, TL; Rhee, SG | 1 |
| Chen, DY; Hou, Y; Li, M; Liang, CG; Lin, SL; Schatten, H; Sun, QY; Xiong, B; Xu, BZ | 1 |
| Lin, CC; Lin, WN; Luo, SF; Wu, CB; Yang, CM | 1 |
| Jeong, M; Jin, YW; Kim, CS; Kim, HS; Kim, J; Kim, JK; Nam, SY; Yang, KH | 1 |
| Danesi, R; Giaccone, G; Giovannetti, E; Lemos, C; Nannizzi, S; Peters, GJ; Ricciardi, S; Rodriguez, JA; Smid, K; Tekle, C | 1 |
| Aird, WC; Hwang, TL; Lee, CW; Lee, HC; Lee, IT; Lin, CC; Luo, SF; Yang, CM | 1 |
| Blagbrough, IS; Farghaly, HS; Medina-Tato, DA; Watson, ML | 1 |
| Claasen, J; Sos, ML; Staratschek-Jox, A; Thomas, RK; Wolf, J; Zander, T | 1 |
| Bologna, M; Dolo, V; Festuccia, C; Gravina, GL; Millimaggi, D; Muzi, P; Vicentini, C | 1 |
| Conaway, M; Gioeli, D; Theodorescu, D; Weber, MJ; Wu, Z | 1 |
| Andina, N; Dahinden, CA; Didichenko, S; Schmidt-Mende, J; Simon, HU | 1 |
| Deng, QF; Su, B; Zhao, YM; Zhou, CC | 1 |
| Evans, CP; Gandara, DR; Gautschi, O; Green, TP; Gumerlock, PH; Kung, HJ; Lara, PN; Mack, PC; Purnell, PR; Tepper, CG | 1 |
| Kohsaka, S; Maeda, S; Nakajima, K; Tohyama, Y | 1 |
| Feng, R; Hu, Q; Li, L; Li, M; Wang, S; Wen, J; Yang, X; Zhang, L | 1 |
| Mekada, E; Miyamoto, S; Mizushima, H; Wang, X | 1 |
| Hao, YY; Iwamori, M; Li, FF; Lin, B; Liu, DW; Liu, JJ; Qi, Y; Zhang, SL; Zhu, LC | 1 |
| Knight, ZA | 1 |
| Arnoletti, JP; Frolov, A; Heslin, MJ; Howard, JH; Kossenkov, AV; Kulesza, P; Liles, JS; Tzeng, CW | 1 |
| Barata, JT; Batista, A; Cardoso, AA; Carlesso, N; Nadler, LM; Raderschall, E; Sallan, SE | 1 |
| Chuu, CP; Kuo, LK; Lin, HP | 1 |
| Grandal, MV; Grøvdal, LM; Holst, MR; Kim, J; Knudsen, SL; van Deurs, B | 1 |
| Black, JL; Burgess, JK; Ge, Q; Moir, LM; Niimi, K; Oliver, BG; Poniris, M; Shepherd, PR; Trian, T | 1 |
| Cicha, I; Daniel, WG; Garlichs, CD; Urschel, K | 1 |
| Li, H; Schmid-Bindert, G; Su, B; Wang, D; Yang, X; Zhao, Y; Zhou, C | 1 |
| Groves, AK; Segil, N; Stone, JS; White, PM | 1 |
| Barnes, PJ; Ito, K; Ito, M; Osoata, G; Rossios, C; To, Y | 1 |
| Pick, A; Wiese, M | 1 |
| Fu, S; Li, P; Li, ZB; Lu, B; Torossian, A; Xu, WC; Zhang, Q | 1 |
| Barth, M; Fender, AC; Fischer, JW; Hohlfeld, T; Kurt, M; Mahajan, SG; Meyer-Kirchrath, J; Rauch, BH; Sagban, TA; Schrör, K | 1 |
| Fu, S; Li, P; Torossian, A; Xu, WC; Zhang, Q | 1 |
| Al Saleh, S; Khajah, MA; Luqmani, YA; Mathew, PM | 1 |
| Guo, Q; Ma, C; Song, X; Wang, X; Wei, L; Zuo, W | 1 |
| Chen, Z; Han, R; Sun, L; Wang, J; Wang, X; Zhang, J; Zhao, J; Zhong, D | 1 |
| Liu, YP; Luo, YH; Song, JG; Sun, P; Xu, HM; Zhang, L; Zhang, XJ | 1 |
| Inase, N; Miyazaki, Y; Okayasu, K; Sumi, Y; Takayama, S; Tamaoka, M; Yoshizawa, Y | 1 |
| Liu, Y; Shi, HL; Wu, XJ; Xie, JQ | 1 |
| Dixon, SJ; Jirik, FR; Kashishian, A; Lannutti, BJ; Pereverzev, A; Puri, KD; Shugg, RP; Sims, SM; Steiner, BH; Tanabe, N; Thomson, A | 1 |
| Hellman, U; Kazi, JU; Lundby, A; Mohlin, S; Olsen, JV; Påhlman, S; Rönnstrand, L; Sun, J | 1 |
| Han, D; Sun, J; Wang, F; Xiao, W; Zhu, Y | 1 |
| Eräsalo, H; Hämäläinen, M; Laavola, M; Leppänen, T; Moilanen, E; Nieminen, R | 1 |
| Fujiki, K; Inamura, H; Matsuoka, M | 1 |
| Kimura, M; Moteki, H; Ogihara, M | 1 |
| Assaraf, YG; Azzariti, A; Giovannetti, E; Jansen, G; Kathman, I; Paradiso, A; Peters, GJ; Porcelli, L; Scheffer, GL | 1 |
| Eliopoulos, AG; Sourvinos, G; Vlahava, VM | 1 |
| Cho, SD; Kim, Y; Lee, JS; Sachita, K; Yu, HJ | 1 |
| Chen, J; Li, L; Luo, M; Pan, L; Qin, G; Qin, S; Yang, J; Zhang, Q | 1 |
| Du, J; Hu, H; Li, C; Li, H; Li, Y; Wang, L; Yang, H; Zhang, Z | 1 |
| Sui, JQ; Xie, KP; Xie, MJ | 1 |
| Battastini, AM; Coelho, BP; de Quadros, AH; Gaelzer, MM; Gonçalves, CA; Guerra, MC; Guma, FC; Hoppe, JB; Salbego, CG; Setton-Avruj, P; Terra, SR; Usach, V | 1 |
| Chen, G; Hossain, MM; Hu, B; Meng, X; Sun, Y; Zhang, X | 1 |
| Chen, Y; Dendy, M; Gruvberger-Saal, SK; Hibshoosh, H; Horlings, HM; Isola, J; Jumppanen, M; Lau, YK; Maurer, M; Memeo, L; Parsons, R; Rosen, N; Saal, LH; She, QB; Su, T; van de Vijver, MJ | 1 |
| Li, Y; Liu, W; Luo, E; Tian, L; Wang, Y; Wen, L; Wen, M; Wen, N; Yang, H; Yun, Y; Zhang, W; Zhao, L; Zhu, X | 1 |
| Cai, L; Chen, X; He, J; Lan, P; Li, L; Li, X; Zhang, X | 1 |
| Block, CJ; Chen, W; Craig, DB; Dong, L; Jang, H; Meng, F; Mitchell, AV; Wu, G; Wu, L; Yang, Q; Zhang, B | 1 |
| Almeida, VH; Berzoti-Coelho, MG; Borges, CS; Cacemiro, MDC; Castro, FA; Ferreira, AF; Figueiredo-Pontes, LL; Gomes, FG; Monteiro, RQ; Nunes, NS; Simões, BP | 1 |
| Gupta, P; Mukhopadhyay, CK; Pandey, HS; Seth, P; Singh, P | 1 |
1 review(s) available for quinazolines and 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one
| Article | Year |
|---|---|
Small molecule inhibitors of the PI3-kinase family.
Topics: Adenine; Androstadienes; Animals; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Chromones; DNA-Activated Protein Kinase; DNA-Binding Proteins; Humans; Morpholines; Neoplasms; Nuclear Proteins; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Quinazolines; Tumor Suppressor Proteins; Wortmannin | 2010 |
1 trial(s) available for quinazolines and 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one
| Article | Year |
|---|---|
Local recurrence in head and neck cancer: relationship to radiation resistance and signal transduction.
Topics: Adult; Aged; Aged, 80 and over; Blotting, Western; Carcinoma, Squamous Cell; Cell Division; Chromones; Dose-Response Relationship, Radiation; Enzyme Inhibitors; ErbB Receptors; Female; Gefitinib; Humans; Immunoenzyme Techniques; Male; Middle Aged; Morpholines; Neoplasm Recurrence, Local; Neoplasm Staging; Oropharyngeal Neoplasms; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Prognosis; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quinazolines; Radiation Tolerance; ras Proteins; Signal Transduction | 2002 |
93 other study(ies) available for quinazolines and 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one
| Article | Year |
|---|---|
Epidermal growth factor stimulates 3-hydroxy-3-methylglutaryl-coenzyme A reductase expression via the ErbB-2 pathway in human breast adenocarcinoma cells.
Topics: Adenocarcinoma; Breast Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Chromones; Epidermal Growth Factor; ErbB Receptors; Female; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein-Tyrosine Kinases; Quinazolines; Receptor, ErbB-2; Signal Transduction; Tumor Cells, Cultured; Tyrphostins | 1999 |
Intracellular movement of green fluorescent protein-tagged phosphatidylinositol 3-kinase in response to growth factor receptor signaling.
Topics: Animals; Biological Transport; Cell Line; Cell Membrane; Chromones; Cytochalasin D; Cytoplasm; Epidermal Growth Factor; ErbB Receptors; Green Fluorescent Proteins; Humans; Luminescent Proteins; Mice; Microscopy, Fluorescence; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins; Quinazolines; Receptor, ErbB-3; Recombinant Fusion Proteins; Signal Transduction; src Homology Domains; Transfection; Tyrphostins | 1999 |
Phosphorylation and nuclear exclusion of the forkhead transcription factor FKHR after epidermal growth factor treatment in human breast cancer cells.
Topics: Alkaline Phosphatase; Biological Transport; Breast Neoplasms; Cell Nucleus; Chromones; Cytoplasm; DNA-Binding Proteins; Epidermal Growth Factor; ErbB Receptors; Female; Forkhead Box Protein O1; Forkhead Transcription Factors; Gene Expression Regulation, Neoplastic; Humans; Macromolecular Substances; Morpholines; Neoplasm Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-cbl; Quinazolines; Signal Transduction; Transcription Factors; Tumor Cells, Cultured; Tyrphostins; Ubiquitin-Protein Ligases | 2000 |
TGF-beta inhibits p70 S6 kinase via protein phosphatase 2A to induce G(1) arrest.
Topics: Activin Receptors, Type I; Androstadienes; Animals; Cells, Cultured; Chromones; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epithelial Cells; ErbB Receptors; Fibroblasts; G1 Phase; Morpholines; Mutation; Phosphoprotein Phosphatases; Phosphorylation; Protein Biosynthesis; Protein Phosphatase 2; Protein Serine-Threonine Kinases; Quinazolines; Receptor, Transforming Growth Factor-beta Type I; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Ribosomal Protein S6 Kinases; S Phase; Signal Transduction; Sirolimus; Smad2 Protein; Trans-Activators; Transforming Growth Factor beta; Wortmannin | 2000 |
Ceramide-dependent regulation of p42/p44 mitogen-activated protein kinase and c-Jun N-terminal-directed protein kinase in cultured airway smooth muscle cells.
Topics: Animals; Cell Membrane Permeability; Cell Survival; Cells, Cultured; Ceramides; Chromones; Enzyme Activation; Guinea Pigs; Isoenzymes; JNK Mitogen-Activated Protein Kinases; Lysophospholipids; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Muscle, Smooth; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Platelet-Derived Growth Factor; Precipitin Tests; Protein Kinase C; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-raf; Quinazolines; Respiratory System; Signal Transduction; Sphingosine; Tyrphostins | 2000 |
Matrix-independent survival of human keratinocytes through an EGF receptor/MAPK-kinase-dependent pathway.
Topics: bcl-X Protein; Calcium-Calmodulin-Dependent Protein Kinases; Caspase Inhibitors; Caspases; Cell Survival; Cells, Cultured; Chromones; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Extracellular Matrix; Flavonoids; Humans; In Situ Nick-End Labeling; Keratinocytes; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Morpholines; Oligopeptides; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Tyrphostins | 2001 |
Transforming growth factor beta1 (TGF-beta1) promotes endothelial cell survival during in vitro angiogenesis via an autocrine mechanism implicating TGF-alpha signaling.
Topics: Androstadienes; Animals; Blotting, Northern; Blotting, Western; Cell Death; Cell Line; Cell Survival; Cells, Cultured; Chromones; Collagen Type I; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Neovascularization, Physiologic; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Binding; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Time Factors; Transforming Growth Factor alpha; Transforming Growth Factor beta; Transforming Growth Factor beta1; Tyrphostins; Wortmannin | 2001 |
Hydrogen peroxide activates endothelial nitric-oxide synthase through coordinated phosphorylation and dephosphorylation via a phosphoinositide 3-kinase-dependent signaling pathway.
Topics: Animals; Aorta; Arginine; Calcium Signaling; Cells, Cultured; Chromones; Citrulline; Egtazic Acid; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Hydrogen Peroxide; Kinetics; Morpholines; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphoserine; Phosphothreonine; Quinazolines; Signal Transduction; Swine; Tyrphostins | 2002 |
Establishment and characterization of acquired resistance to the farnesyl protein transferase inhibitor R115777 in a human colon cancer cell line.
Topics: Alkyl and Aryl Transferases; Antineoplastic Agents; Blotting, Western; Cell Division; Chromones; Colorectal Neoplasms; Drug Resistance, Neoplasm; ErbB Receptors; Farnesyltranstransferase; Humans; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Quinazolines; Quinolones; Transfection; Tumor Cells, Cultured | 2002 |
Epidermal growth factor inhibition of c-Myc-mediated apoptosis through Akt and Erk involves Bcl-xL upregulation in mammary epithelial cells.
Topics: Animals; Apoptosis; bcl-X Protein; Butadienes; Cell Line; Chromones; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinases; Morpholines; Nitriles; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-myc; Quinazolines; Up-Regulation | 2003 |
Selective role of PI3K delta in neutrophil inflammatory responses.
Topics: Adenine; Androstadienes; Animals; Anti-Inflammatory Agents; Chromones; Class I Phosphatidylinositol 3-Kinases; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Exocytosis; Inflammation; Leukocyte Elastase; Mice; Mice, Inbred BALB C; Morpholines; Neutrophils; Phosphatidylinositol 3-Kinases; Protein Isoforms; Quinazolines; Signal Transduction; Superoxides; Time Factors; Wortmannin | 2003 |
Epidermal growth factor receptor-dependent, NF-kappaB-independent activation of the phosphatidylinositol 3-kinase/Akt pathway inhibits ultraviolet irradiation-induced caspases-3, -8, and -9 in human keratinocytes.
Topics: Acrylamides; Adenoviridae; Apoptosis; Caspase 3; Caspase 8; Caspase 9; Caspases; Chromones; Cytosol; DNA Fragmentation; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; ErbB Receptors; Flow Cytometry; Humans; Keratinocytes; Microscopy, Fluorescence; Morpholines; NF-kappa B; Oxidative Stress; Phosphatidylinositol 3-Kinases; Phosphorylation; Precipitin Tests; Quinazolines; Ultraviolet Rays | 2003 |
Resistance to gefitinib in PTEN-null HER-overexpressing tumor cells can be overcome through restoration of PTEN function or pharmacologic modulation of constitutive phosphatidylinositol 3'-kinase/Akt pathway signaling.
Topics: Breast Neoplasms; Chromones; Down-Regulation; Drug Resistance, Neoplasm; Enzyme Inhibitors; Epidermal Growth Factor; Female; Gefitinib; Genes, Tumor Suppressor; Humans; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoric Monoester Hydrolases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quinazolines; Receptor, ErbB-2; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Transfection; Tumor Cells, Cultured | 2003 |
PI3-kinase upregulation and involvement in spontaneous tone in arteries from DOCA-salt rats: is p110delta the culprit?
Topics: Adenine; Animals; Aorta; Chromones; Class I Phosphatidylinositol 3-Kinases; Desoxycorticosterone; Disease Models, Animal; Enzyme Induction; Enzyme Inhibitors; Hypertension; Male; Mesenteric Arteries; Morpholines; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Isoforms; Protein Subunits; Quinazolines; Rats; Rats, Sprague-Dawley; Sodium Chloride; Vascular Resistance | 2004 |
Modulation of DNA repair in vitro after treatment with chemotherapeutic agents by the epidermal growth factor receptor inhibitor gefitinib (ZD1839).
Topics: Antineoplastic Agents; Cell Division; Cell Line, Tumor; Chromones; Cisplatin; Comet Assay; DNA Damage; DNA Repair; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; ErbB Receptors; Etoposide; Gefitinib; Humans; Melphalan; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinazolines; Signal Transduction; Time Factors | 2004 |
Angiotensin II regulation of TGF-beta in murine mesangial cells involves both PI3 kinase and MAP kinase.
Topics: Angiotensin II; Animals; Butadienes; Cell Line; Chromones; Dose-Response Relationship, Drug; Drug Combinations; Enzyme Inhibitors; Epidermal Growth Factor; Glomerular Mesangium; Immunoblotting; Losartan; Mice; Mitogen-Activated Protein Kinase Kinases; Morpholines; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinazolines; Receptor, Angiotensin, Type 1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Transforming Growth Factor beta; Tyrphostins | 2004 |
Mechanical stretch stimulates protein kinase B/Akt phosphorylation in epidermal cells via angiotensin II type 1 receptor and epidermal growth factor receptor.
Topics: Androstadienes; Apoptosis; Caspase 3; Caspase 8; Caspases; Cell Line; Cell Membrane; Cell Proliferation; Chromones; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Epidermal Cells; Epidermis; Epithelial Cells; ErbB Receptors; Genes, Dominant; Humans; Immunoblotting; Microscopy, Confocal; Morpholines; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quinazolines; Receptor, Angiotensin, Type 1; Signal Transduction; Threonine; Time Factors; Tyrphostins; Wortmannin | 2005 |
Protein kinase C zeta is required for epidermal growth factor-induced chemotaxis of human breast cancer cells.
Topics: Alkaloids; Benzophenanthridines; Breast Neoplasms; Cell Line, Tumor; Chemokine CXCL12; Chemokines, CXC; Chemotaxis; Chromones; Epidermal Growth Factor; ErbB Receptors; Humans; Morpholines; Phenanthridines; Protein Kinase C; Protein Kinase Inhibitors; Quinazolines; Tyrphostins | 2005 |
Differential sensitivities of trastuzumab (Herceptin)-resistant human breast cancer cells to phosphoinositide-3 kinase (PI-3K) and epidermal growth factor receptor (EGFR) kinase inhibitors.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chromones; Drug Resistance, Neoplasm; ErbB Receptors; Female; Humans; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quinazolines; Receptor, ErbB-2; Signal Transduction; Trastuzumab; Tumor Cells, Cultured; Tyrphostins | 2005 |
Therapeutic targeting of multiple signaling pathways in malignant pleural mesothelioma.
Topics: Antibiotics, Antineoplastic; Butadienes; Cell Cycle; Chromones; Enzyme Inhibitors; ErbB Receptors; Gene Expression Regulation, Neoplastic; Humans; Lapatinib; Mesothelioma; Mitogen-Activated Protein Kinase 3; Morpholines; Nitriles; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Pleural Neoplasms; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quinazolines; Receptor, ErbB-2; Receptor, ErbB-3; Receptor, ErbB-4; Signal Transduction; Sirolimus; Transforming Growth Factor alpha; Tumor Cells, Cultured | 2005 |
Upregulated function of phosphatidylinositol-3-kinase in genetically hypertensive rats: a moderator of arterial hypercontractility.
Topics: Adenine; Animals; Aorta; Blotting, Western; Chromones; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Hypertension; Immunohistochemistry; In Vitro Techniques; Male; Morpholines; Norepinephrine; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinazolines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Time Factors; Up-Regulation; Vasoconstriction; Vasoconstrictor Agents | 2005 |
Molecular aspects of gefitinib antiproliferative and pro-apoptotic effects in PTEN-positive and PTEN-negative prostate cancer cell lines.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Chromones; Drug Resistance, Neoplasm; ErbB Receptors; G1 Phase; Gefitinib; Humans; Male; Mitogen-Activated Protein Kinase Kinases; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Prostatic Neoplasms; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Quinazolines | 2005 |
Critical role of PI3-kinase/Akt activation in the PARP inhibitor induced heart function recovery during ischemia-reperfusion.
Topics: Androstadienes; Animals; Benzimidazoles; Blotting, Western; Cell Line; Chromones; Enzyme Activation; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Heart; In Vitro Techniques; Lipid Peroxidation; Male; Morpholines; Myocardial Reperfusion Injury; Perfusion; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Poly(ADP-ribose) Polymerase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; Quinazolinones; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances; Ventricular Function, Left; Wortmannin | 2006 |
The epidermal growth factor receptor (EGFR)-S442F mutant displays increased affinity for neuregulin-2beta and agonist-independent coupling with downstream signalling events.
Topics: Amino Acid Substitution; Animals; Apoptosis; Binding Sites; Cell Line; Chromones; Epidermal Growth Factor; ErbB Receptors; Genes, erbB-1; Humans; Hydrophobic and Hydrophilic Interactions; Ligands; Mice; Morpholines; Mutation, Missense; Myeloid Cells; Neuregulins; Phosphatidylinositol 3-Kinases; Phosphorylation; Point Mutation; Protein Binding; Protein Interaction Mapping; Protein Processing, Post-Translational; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quinazolines; Recombinant Fusion Proteins; Signal Transduction; Transfection | 2006 |
AP-2alpha: a regulator of EGF receptor signaling and proliferation in skin epidermis.
Topics: Animals; Animals, Newborn; Calcium; Caspase 3; Caspases; Cell Proliferation; Chromatin Immunoprecipitation; Chromones; Dermis; DNA; Embryo, Mammalian; Enzyme Inhibitors; Epidermal Cells; Epidermal Growth Factor; Epidermis; ErbB Receptors; Gene Expression; Gene Expression Regulation; Hair Diseases; Integrases; Keratinocytes; Keratins; Ki-67 Antigen; MAP Kinase Signaling System; Mice; Mice, Transgenic; Morpholines; Phosphorylation; Promoter Regions, Genetic; Proto-Oncogene Proteins c-akt; Quinazolines; Signal Transduction; Skin; Skin Abnormalities; Tetradecanoylphorbol Acetate; Transcription Factor AP-2; Transforming Growth Factor alpha; Tyrphostins | 2006 |
The effects of ZD1839 (Iressa), a highly selective EGFR tyrosine kinase inhibitor, as a radiosensitiser in bile duct carcinoma cell lines.
Topics: Anthracenes; Bile Duct Neoplasms; Butadienes; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chromones; Clone Cells; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Gefitinib; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Morpholines; Nitriles; Oncogene Protein v-akt; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Quinazolines; Radiation-Sensitizing Agents | 2006 |
Inhibition of the mitotic kinesin Eg5 up-regulates Hsp70 through the phosphatidylinositol 3-kinase/Akt pathway in multiple myeloma cells.
Topics: Apoptosis; Cell Line, Tumor; Chromones; Enzyme Inhibitors; Growth Inhibitors; HSP70 Heat-Shock Proteins; Humans; Kinesins; Morpholines; Multiple Myeloma; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Quinazolines; RNA, Small Interfering; Spindle Apparatus; Transcription, Genetic; Up-Regulation | 2006 |
Inhibition of EGFR/PI3K/AKT cell survival pathway promotes TSA's effect on cell death and migration in human ovarian cancer cells.
Topics: Acetylation; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Chromones; Dose-Response Relationship, Drug; Enzyme Inhibitors; ErbB Receptors; Female; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Inhibitor of Apoptosis Proteins; Microtubule-Associated Proteins; Morpholines; Neoplasm Proteins; Ovarian Neoplasms; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; Signal Transduction; Survivin; Time Factors | 2006 |
Synthesis and biological evaluation of 4-morpholino-2-phenylquinazolines and related derivatives as novel PI3 kinase p110alpha inhibitors.
Topics: Animals; Cattle; Cell Line, Tumor; Cell Proliferation; Chromones; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; Molecular Structure; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Quinazolines; Stereoisomerism; Structure-Activity Relationship | 2006 |
The p110delta isoform of PI3K differentially regulates beta1 and beta2 integrin-mediated monocyte adhesion and spreading and modulates diapedesis.
Topics: Adenine; Androstadienes; CD18 Antigens; cdc42 GTP-Binding Protein; Cell Line; Cell Movement; Chromones; Class I Phosphatidylinositol 3-Kinases; Gene Expression Regulation; Humans; Integrin alpha4beta1; Integrin beta1; Intercellular Adhesion Molecule-1; Lymphocyte Function-Associated Antigen-1; Monocytes; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Quinazolines; rac1 GTP-Binding Protein; Signal Transduction; Vascular Cell Adhesion Molecule-1; Wortmannin | 2006 |
UVB radiation induces expression of HIF-1alpha and VEGF through the EGFR/PI3K/DEC1 pathway.
Topics: Androstadienes; Blotting, Western; Cell Line; Chromones; Dose-Response Relationship, Radiation; Enzyme-Linked Immunosorbent Assay; ErbB Receptors; Gene Expression; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Keratinocytes; Morpholines; Mutation; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Time Factors; Transcription, Genetic; Tumor Suppressor Proteins; Ultraviolet Rays; Vascular Endothelial Growth Factor A; Wortmannin | 2006 |
EGFR-activated signaling and actin remodeling regulate cyclic stretch-induced NRF2-ARE activation.
Topics: Actins; Animals; Antioxidants; Chromones; Endothelial Cells; Epithelial Cells; ErbB Receptors; Gene Expression Regulation; Lung; Mice; Morpholines; NF-E2-Related Factor 2; Oxidants; Oxidative Stress; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Quinazolines; Rats; Response Elements; RNA, Messenger; Signal Transduction; Stress, Mechanical; Transcription, Genetic; Tyrphostins | 2007 |
Inhibition of ADAM17 reduces hypoxia-induced brain tumor cell invasiveness.
Topics: ADAM Proteins; ADAM17 Protein; Animals; Blotting, Western; Cell Hypoxia; Cell Line, Tumor; Cell Movement; Chromones; Enzyme Inhibitors; Gene Expression; Glioma; Gliosarcoma; Humans; Hydroxamic Acids; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Morpholines; Neoplasm Invasiveness; Proto-Oncogene Proteins c-akt; Quinazolines; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; RNA, Small Interfering; Transfection; Tyrphostins | 2007 |
Epiregulin promotes proliferation and migration of renal proximal tubular cells.
Topics: Animals; Blotting, Western; Butadienes; Cell Cycle; Cell Movement; Cell Proliferation; Cells, Cultured; Chromones; Enzyme Inhibitors; Epidermal Growth Factor; Epiregulin; ErbB Receptors; Female; Kidney Tubules, Proximal; Mitogen-Activated Protein Kinases; Morpholines; Nitriles; Oncogene Protein v-akt; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinazolines; Rabbits; Tyrphostins; Wound Healing | 2007 |
The control of tissue architecture over nuclear organization is crucial for epithelial cell fate.
Topics: Antigens, Neoplasm; Antigens, Nuclear; Apoptosis; beta Catenin; Cell Culture Techniques; Cell Cycle; Cell Cycle Proteins; Cell Differentiation; Cell Line; Cell Line, Tumor; Cell Nucleus; Cell Polarity; Chromones; Collagen Type IV; Enzyme Inhibitors; Epigenesis, Genetic; Epithelial Cells; ErbB Receptors; Histones; Humans; Integrin alpha6; Ki-67 Antigen; Membrane Proteins; Morpholines; Mucin-1; Mucins; Neoplasm Proteins; Nuclear Matrix-Associated Proteins; Nuclear Proteins; Phosphoproteins; Promyelocytic Leukemia Protein; Quinazolines; RNA, Small Interfering; Transcription Factors; Tumor Suppressor Proteins; Tyrphostins; Zonula Occludens-1 Protein | 2007 |
Activation of NADPH oxidase by transforming growth factor-beta in hepatocytes mediates up-regulation of epidermal growth factor receptor ligands through a nuclear factor-kappaB-dependent mechanism.
Topics: Acetophenones; Animals; Anthracenes; Benzamides; Chromones; Dioxoles; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Heparin-binding EGF-like Growth Factor; Hepatocytes; Humans; Imidazoles; Intercellular Signaling Peptides and Proteins; Morpholines; NADH, NADPH Oxidoreductases; NADPH Oxidase 1; NADPH Oxidase 4; NADPH Oxidases; NF-kappa B; Onium Compounds; Peptides; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Quinazolines; rac1 GTP-Binding Protein; Rats; Reactive Oxygen Species; Transforming Growth Factor beta; Tyrphostins; Up-Regulation | 2007 |
Molecular mechanisms of ZD1839 (Iressa)-induced apoptosis in human leukemic U937 cells.
Topics: Antineoplastic Agents; Apoptosis; Caspase Inhibitors; Chromones; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Gefitinib; Humans; MAP Kinase Signaling System; Morpholines; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-bcl-2; Quinazolines; U937 Cells; X-Linked Inhibitor of Apoptosis Protein | 2007 |
Mechanism of angiotensin II-induced superoxide production in cells reconstituted with angiotensin type 1 receptor and the components of NADPH oxidase.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Androstadienes; Angiotensin II; Animals; Cell Line; CHO Cells; Chromones; Cricetinae; Cricetulus; Gene Expression; Humans; Indoles; Maleimides; Membrane Glycoproteins; Morpholines; Mutation; NADPH Oxidase 1; NADPH Oxidase 2; NADPH Oxidases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Protein Kinase C; Pyrazoles; Pyrimidines; Quinazolines; Receptor, Angiotensin, Type 1; Reverse Transcriptase Polymerase Chain Reaction; Superoxides; Tyrphostins; Wortmannin | 2008 |
PI3-kinase and mitogen-activated protein kinase in cumulus cells mediate EGF-induced meiotic resumption of porcine oocyte.
Topics: Animals; Butadienes; Cells, Cultured; Chromones; Cumulus Cells; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Female; Meiosis; Mitogen-Activated Protein Kinases; Morpholines; Nitriles; Oocytes; Phosphatidylinositol 3-Kinases; Phosphorylation; Quinazolines; Swine; Tyrphostins | 2008 |
Lipopolysaccharide induces VCAM-1 expression and neutrophil adhesion to human tracheal smooth muscle cells: involvement of Src/EGFR/PI3-K/Akt pathway.
Topics: Androstadienes; Blotting, Western; Cell Adhesion; Cell Line; Chromones; Dose-Response Relationship, Drug; E1A-Associated p300 Protein; ErbB Receptors; Humans; Lipopolysaccharides; Morpholines; Myocytes, Smooth Muscle; Neutrophils; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Signal Transduction; src-Family Kinases; Trachea; Transfection; Tyrphostins; Vascular Cell Adhesion Molecule-1; Wortmannin | 2008 |
Low-dose radiation stimulates the proliferation of normal human lung fibroblasts via a transient activation of Raf and Akt.
Topics: Cell Proliferation; Chromones; Enzyme Activation; Fibroblasts; Gamma Rays; Humans; Lung; Morpholines; p21-Activated Kinases; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-raf; Quinazolines; Signal Transduction; Tumor Suppressor Protein p53; Tyrphostins | 2007 |
Molecular mechanisms underlying the synergistic interaction of erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor, with the multitargeted antifolate pemetrexed in non-small-cell lung cancer cells.
Topics: Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Catalysis; Cell Cycle; Cell Death; Cell Extracts; Cell Line, Tumor; Chromones; Drug Screening Assays, Antitumor; Drug Synergism; E2F1 Transcription Factor; ErbB Receptors; Erlotinib Hydrochloride; Extracellular Signal-Regulated MAP Kinases; Folic Acid Antagonists; Gene Expression Regulation, Neoplastic; Glutamates; Guanine; Humans; Lung Neoplasms; Morpholines; Pemetrexed; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines; RNA, Messenger; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase | 2008 |
Tumor necrosis factor-alpha enhances neutrophil adhesiveness: induction of vascular cell adhesion molecule-1 via activation of Akt and CaM kinase II and modifications of histone acetyltransferase and histone deacetylase 4 in human tracheal smooth muscle c
Topics: Active Transport, Cell Nucleus; Antibodies; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calmodulin; Cell Adhesion; Cell Nucleus; Chromones; E1A-Associated p300 Protein; Enzyme Activation; Gene Expression Regulation; Histone Acetyltransferases; Histone Deacetylases; Humans; Isoenzymes; Morpholines; Myocytes, Smooth Muscle; Neutrophils; Phosphorylation; Promoter Regions, Genetic; Protein Kinase C; Proto-Oncogene Proteins c-akt; Pyrazoles; Pyrimidines; Quinazolines; Repressor Proteins; Trachea; Tumor Necrosis Factor-alpha; Tyrphostins; Vascular Cell Adhesion Molecule-1 | 2008 |
Interleukin 13 increases contractility of murine tracheal smooth muscle by a phosphoinositide 3-kinase p110delta-dependent mechanism.
Topics: Adenine; Animals; Bronchial Hyperreactivity; Carbachol; Chromones; Class I Phosphatidylinositol 3-Kinases; In Vitro Techniques; Interleukin-13; Isoenzymes; Lung; Mice; Mice, Mutant Strains; Morpholines; Muscle Contraction; Muscle, Smooth; Mutant Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Potassium Chloride; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; Tissue Extracts; Trachea | 2008 |
Expression of signaling mediators downstream of EGF-receptor predict sensitivity to small molecule inhibitors directed against the EGF-receptor pathway.
Topics: Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Chromones; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; ErbB Receptors; Farnesyltranstransferase; Gefitinib; Humans; Lung Neoplasms; MAP Kinase Signaling System; Morpholines; Phosphatidylinositols; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins p21(ras); PTEN Phosphohydrolase; Quinazolines; ras Proteins; Sirolimus | 2008 |
Akt down-modulation induces apoptosis of human prostate cancer cells and synergizes with EGFR tyrosine kinase inhibitors.
Topics: Apoptosis; Blotting, Western; Caspases; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chromones; Drug Synergism; Enzyme Activation; Epidermal Growth Factor; Erlotinib Hydrochloride; Flow Cytometry; Humans; Male; Morpholines; Neoplasms, Hormone-Dependent; Phosphorylcholine; Prostatic Neoplasms; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Quinazolines | 2008 |
Restoration of PTEN expression alters the sensitivity of prostate cancer cells to EGFR inhibitors.
Topics: Benzamides; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Chromones; ErbB Receptors; Gefitinib; Humans; Lapatinib; Male; Mitogen-Activated Protein Kinases; Morpholines; Neoplasms, Hormone-Dependent; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Prostatic Neoplasms; Protein Kinase Inhibitors; PTEN Phosphohydrolase; Quinazolines | 2008 |
Proviral integration site for Moloney murine leukemia virus 1, but not phosphatidylinositol-3 kinase, is essential in the antiapoptotic signaling cascade initiated by IL-5 in eosinophils.
Topics: Adenine; Androstadienes; Apoptosis; Cells, Cultured; Chromones; Eosinophils; Humans; Hypersensitivity; Interleukin-5; Janus Kinase 2; Microscopy, Confocal; Morpholines; Myeloid Cell Leukemia Sequence 1 Protein; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-pim-1; Quinazolines; Tyrphostins; Wortmannin; Xanthenes | 2009 |
[Sensitivity of two cell lines with acquired resistance to gefitinib to several chemotherapeutic drugs].
Topics: Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Chromones; Docetaxel; Drug Resistance, Neoplasm; Gefitinib; Glutamates; Guanine; Humans; Integrin beta1; Lung Neoplasms; Morpholines; Pemetrexed; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; Taxoids | 2008 |
The Src inhibitor AZD0530 blocks invasion and may act as a radiosensitizer in lung cancer cells.
Topics: Benzodioxoles; Cell Line, Tumor; Cell Movement; Chromones; Focal Adhesion Protein-Tyrosine Kinases; Humans; Janus Kinase 3; Lung Neoplasms; Morpholines; Neoplasm Invasiveness; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Quinazolines; Radiation-Sensitizing Agents; Signal Transduction; src-Family Kinases; STAT3 Transcription Factor | 2009 |
Characteristic response of astrocytes to plasminogen/plasmin to upregulate transforming growth factor beta 3 (TGFbeta3) production/secretion through proteinase-activated receptor-1 (PAR-1) and the downstream phosphatidylinositol 3-kinase (PI3K)-Akt/PKB si
Topics: Analysis of Variance; Animals; Astrocytes; Blotting, Western; Cells, Cultured; Chromones; Culture Media, Conditioned; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibrinolysin; Fibrinolytic Agents; Fibroblast Growth Factors; Flavonoids; Immunohistochemistry; Microglia; Morpholines; Nerve Growth Factors; Neurons; Phosphatidylinositol 3-Kinases; Phosphorylation; Plasminogen; Proto-Oncogene Proteins c-akt; Pyrroles; Quinazolines; Rats; Receptor, PAR-1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Transforming Growth Factor beta3 | 2009 |
The EGF receptor-sox2-EGF receptor feedback loop positively regulates the self-renewal of neural precursor cells.
Topics: Animals; Blotting, Western; Butadienes; Cell Proliferation; Cells, Cultured; Chromatin Immunoprecipitation; Chromones; Enzyme Inhibitors; ErbB Receptors; Immunohistochemistry; In Vitro Techniques; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Neurons; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinazolines; RNA Interference; SOXB1 Transcription Factors; Tyrphostins | 2010 |
Integrin signal masks growth-promotion activity of HB-EGF in monolayer cell cultures.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Adhesion; Cell Culture Techniques; Cell Proliferation; Cells, Cultured; Chromones; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gefitinib; Heparin-binding EGF-like Growth Factor; Humans; Integrins; Intercellular Signaling Peptides and Proteins; Mice; Mice, Nude; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinazolines; Signal Transduction | 2009 |
Lewis(y) antigen stimulates the growth of ovarian cancer cells via regulation of the epidermal growth factor receptor pathway.
Topics: Cell Line, Tumor; Cell Proliferation; Chromones; Cyclin-Dependent Kinase Inhibitor p27; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; Fucosyltransferases; Gefitinib; Humans; Lewis Blood Group Antigens; Morpholines; Ovarian Neoplasms; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines | 2010 |
ErbB3 expression promotes tumorigenesis in pancreatic adenocarcinoma.
Topics: Adenocarcinoma; Animals; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Chromones; Dose-Response Relationship, Drug; ErbB Receptors; Erlotinib Hydrochloride; Female; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, SCID; Morpholines; Pancreatic Neoplasms; Phosphatidylinositol 3-Kinases; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; Receptor, ErbB-3; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Signal Transduction; Tumor Burden; Xenograft Model Antitumor Assays | 2010 |
Targeting of active mTOR inhibits primary leukemia T cells and synergizes with cytotoxic drugs and signaling inhibitors.
Topics: Antibiotics, Antineoplastic; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chromones; Dexamethasone; Doxorubicin; Drug Synergism; Enzyme Inhibitors; Eukaryotic Initiation Factor-4G; Humans; Immunoblotting; Immunohistochemistry; Janus Kinase 3; Microscopy, Fluorescence; Morpholines; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Proto-Oncogene Proteins c-akt; Quinazolines; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2011 |
Combined treatment of curcumin and small molecule inhibitors suppresses proliferation of A549 and H1299 human non-small-cell lung cancer cells.
Topics: Antineoplastic Agents; Biological Availability; Caffeic Acids; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Chromones; Curcuma; Curcumin; Drug Therapy, Combination; Enzyme Inhibitors; ErbB Receptors; Humans; Morpholines; NF-kappa B; Phenylethyl Alcohol; Phosphoinositide-3 Kinase Inhibitors; Phytotherapy; Plant Extracts; Pyrimidines; Quinazolines; Receptors, Fibroblast Growth Factor; Signal Transduction; Somatomedins; Tyrphostins | 2012 |
EGF receptor inhibitors increase ErbB3 mRNA and protein levels in breast cancer cells.
Topics: Breast Neoplasms; Butadienes; Cell Line, Tumor; Chromones; ErbB Receptors; Erlotinib Hydrochloride; Female; Gefitinib; Gene Expression; Gene Expression Profiling; Humans; Imidazoles; MAP Kinase Kinase 1; Morpholines; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyridines; Quinazolines; Receptor, ErbB-2; Receptor, ErbB-3; Receptor, ErbB-4; RNA, Messenger; Signal Transduction; Tyrphostins; Up-Regulation | 2012 |
The phosphoinositide 3'-kinase p110δ modulates contractile protein production and IL-6 release in human airway smooth muscle.
Topics: Adenine; Adult; Aged; Aged, 80 and over; Asthma; Benzamides; Cells, Cultured; Chromones; Class I Phosphatidylinositol 3-Kinases; Contractile Proteins; Dioxoles; Female; Gene Expression Regulation; Humans; Interleukin-6; Lung; Male; Middle Aged; Morpholines; Muscle, Smooth; Phosphatidylinositol 3-Kinases; Pulmonary Disease, Chronic Obstructive; Quinazolines; Tissue Donors; Transforming Growth Factor beta1 | 2012 |
VEGFR2 signalling contributes to increased endothelial susceptibility to TNF-α under chronic non-uniform shear stress.
Topics: Active Transport, Cell Nucleus; Blotting, Western; Cell Adhesion; Cells, Cultured; Chromones; Coculture Techniques; Dose-Response Relationship, Drug; E-Selectin; Fluorescent Antibody Technique; Human Umbilical Vein Endothelial Cells; Humans; Inflammation Mediators; Mechanotransduction, Cellular; Monocytes; Morpholines; NF-kappa B; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Pyrimidines; Quinazolines; RNA Interference; src-Family Kinases; Stress, Mechanical; Transfection; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1; Vascular Endothelial Growth Factor Receptor-2 | 2011 |
Blocking the PI3K/AKT and MEK/ERK signaling pathways can overcome gefitinib-resistance in non-small cell lung cancer cell lines.
Topics: Antineoplastic Agents; Apoptosis; Butadienes; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Chromones; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Flow Cytometry; Gefitinib; Humans; Lung Neoplasms; MAP Kinase Kinase Kinases; Morpholines; Mutation; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; Signal Transduction | 2011 |
EGFR signaling is required for regenerative proliferation in the cochlea: conservation in birds and mammals.
Topics: Animals; Cell Proliferation; Cells, Cultured; Chickens; Chromones; Cochlea; Cyclin-Dependent Kinase Inhibitor p27; ErbB Receptors; Gene Expression Profiling; Green Fluorescent Proteins; Hair Cells, Auditory; Labyrinth Supporting Cells; Mice; Mice, 129 Strain; Mice, Knockout; Mice, Transgenic; Microscopy, Fluorescence; Morpholines; Organ Culture Techniques; Organ of Corti; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinazolines; Receptor, Nerve Growth Factor; Regeneration; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Tyrphostins | 2012 |
Corticosteroid insensitivity is reversed by formoterol via phosphoinositide-3-kinase inhibition.
Topics: 1-Phosphatidylinositol 4-Kinase; Adenine; Adrenal Cortex Hormones; Adrenergic beta-2 Receptor Agonists; Adult; Aged; Albuterol; Androstadienes; Asthma; Budesonide; Chromones; Dexamethasone; Drug Resistance; Ethanolamines; Female; Fluticasone; Formoterol Fumarate; Humans; Hydrogen Peroxide; Interleukin-8; Leukocytes, Mononuclear; Male; Middle Aged; Morpholines; Oxidative Stress; Pulmonary Disease, Chronic Obstructive; Quinazolines; Receptors, Adrenergic, beta-2; Salmeterol Xinafoate; U937 Cells; Young Adult | 2012 |
Tyrosine kinase inhibitors influence ABCG2 expression in EGFR-positive MDCK BCRP cells via the PI3K/Akt signaling pathway.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Benzamides; Benzimidazoles; Cell Line; Cetuximab; Chromones; Dose-Response Relationship, Drug; Drug Resistance, Multiple; ErbB Receptors; Erlotinib Hydrochloride; Gefitinib; Humans; Imatinib Mesylate; Morpholines; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Phosphatidylinositol 3-Kinases; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrimidines; Quinazolines; Signal Transduction; Tyrphostins | 2012 |
Simultaneous inhibition of EGFR and PI3K enhances radiosensitivity in human breast cancer.
Topics: Animals; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Chromones; ErbB Receptors; Female; G1 Phase; Humans; Mice; Mice, Nude; Morpholines; Neoplasm Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Quinazolines; Radiation Tolerance; Radiation-Sensitizing Agents; Random Allocation; Resting Phase, Cell Cycle; Tyrphostins | 2012 |
A novel function of FoxO transcription factors in thrombin-stimulated vascular smooth muscle cell proliferation.
Topics: Cell Proliferation; Cells, Cultured; Chromones; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Endothelium, Vascular; Forkhead Box Protein O1; Forkhead Box Protein O3; Forkhead Transcription Factors; Gene Expression Regulation; Humans; Imidazoles; Morpholines; Myocytes, Smooth Muscle; Oligopeptides; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Pyridines; Pyrroles; Quinazolines; RNA, Small Interfering; Saphenous Vein; Thrombin | 2012 |
Inhibition of phosphoinositide 3-kinase enhances the cytotoxicity of AG1478, an epidermal growth factor receptor inhibitor, in breast cancer cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Chromones; Drug Synergism; Enzyme Inhibitors; ErbB Receptors; Female; Flow Cytometry; Humans; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Quinazolines; Tyrphostins | 2012 |
Differential effect of growth factors on invasion and proliferation of endocrine resistant breast cancer cells.
Topics: Benzamides; Breast Neoplasms; Cell Movement; Cell Proliferation; Chemokine CCL5; Chromones; Collagenases; Diphenylamine; Epidermal Growth Factor; ErbB Receptors; Erlotinib Hydrochloride; Extracellular Signal-Regulated MAP Kinases; Female; Gene Knockdown Techniques; Humans; Insulin-Like Growth Factor I; Lymphokines; MCF-7 Cells; Morpholines; Phosphorylation; Platelet-Derived Growth Factor; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Quinazolines; Receptors, Estrogen; RNA, Small Interfering; Transforming Growth Factor beta | 2012 |
Lapatinib inhibits the activation of NF-κB through reducing phosphorylation of IκB-α in breast cancer cells.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Chromones; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Humans; I-kappa B Proteins; Lapatinib; Morpholines; NF-kappa B; NF-KappaB Inhibitor alpha; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines; Receptor, ErbB-2; Signal Transduction; Time Factors | 2013 |
[Molecular mechanism of erlotinib resistance in epidermal growth factor receptor mutant non-small cell lung cancer cell line H1650].
Topics: Blotting, Western; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Survival; Chromones; Drug Resistance, Neoplasm; Enzyme Inhibitors; ErbB Receptors; Erlotinib Hydrochloride; Humans; Lung Neoplasms; Morpholines; Mutation; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction | 2012 |
[Molecular mechanism of chemosensitization to paclitaxel in human melanoma cells induced by targeting the EGFR signaling pathway].
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chromones; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Melanoma; Morpholines; Paclitaxel; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines; Signal Transduction; Tyrphostins | 2013 |
RANTES expression induced by Toll-like receptor 4 ligand in rat airway smooth muscle cells.
Topics: Animals; Asthma; Cell Culture Techniques; Cells, Cultured; Chemokine CCL11; Chemokine CCL5; Chromones; Dipeptides; ErbB Receptors; Lipopolysaccharides; Male; Matrix Metalloproteinase Inhibitors; Morpholines; Myocytes, Smooth Muscle; Phosphoinositide-3 Kinase Inhibitors; Protein Tyrosine Phosphatases; Quinazolines; Rats, Inbred BN; Signal Transduction; Toll-Like Receptor 4; Trachea; Transcriptional Activation; Tyrphostins | 2010 |
Berberine counteracts enhanced IL-8 expression of AGS cells induced by evodiamine.
Topics: Antineoplastic Agents, Phytogenic; Berberine; Cell Adhesion; Cell Cycle; Cell Movement; Cell Proliferation; Chemokines; Chemokines, CXC; Chromones; Human Umbilical Vein Endothelial Cells; Humans; Imidazoles; Intercellular Adhesion Molecule-1; Interleukin-8; Morpholines; Pyridines; Quinazolines; Signal Transduction; Stomach Neoplasms; Tumor Cells, Cultured | 2013 |
Effects of isoform-selective phosphatidylinositol 3-kinase inhibitors on osteoclasts: actions on cytoskeletal organization, survival, and resorption.
Topics: Adenine; Androstadienes; Animals; Bone Resorption; Cell Survival; Chromones; Cytoskeleton; Indazoles; Isoenzymes; Morpholines; Osteoclasts; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Quinazolines; Rabbits; RANK Ligand; Rats; Sulfonamides; Wortmannin | 2013 |
The PI3-kinase isoform p110δ is essential for cell transformation induced by the D816V mutant of c-Kit in a lipid-kinase-independent manner.
Topics: Adenine; Animals; Binding Sites; Blotting, Western; Cell Line; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Chlorocebus aethiops; Chromones; Class Ia Phosphatidylinositol 3-Kinase; COS Cells; Female; Mice, Inbred Strains; Mice, Nude; Morpholines; Mutation, Missense; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Binding; Proto-Oncogene Proteins c-kit; Quinazolines; RNA Interference; Serine; Tyrosine | 2014 |
MiRNA-181c inhibits EGFR-signaling-dependent MMP9 activation via suppressing Akt phosphorylation in glioblastoma.
Topics: Blotting, Western; Cell Line, Tumor; Chromones; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Matrix Metalloproteinase 9; MicroRNAs; Models, Genetic; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Tyrphostins | 2014 |
PI3K inhibitors LY294002 and IC87114 reduce inflammation in carrageenan-induced paw oedema and down-regulate inflammatory gene expression in activated macrophages.
Topics: Adenine; Animals; Carrageenan; Chemokine CCL2; Chromones; Down-Regulation; Edema; Enzyme Inhibitors; Inflammation; Interleukin-6; Macrophages; Mice; Morpholines; Nitric Oxide Synthase Type II; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Quinazolines; Tumor Necrosis Factor-alpha | 2015 |
Detrimental effects of Notch1 signaling activated by cadmium in renal proximal tubular epithelial cells.
Topics: Cadmium Chloride; Calcium-Binding Proteins; Cell Line; Chromones; Down-Regulation; Epithelial Cells; ErbB Receptors; Humans; Indoles; Intercellular Signaling Peptides and Proteins; Jagged-1 Protein; Jagged-2 Protein; Kidney Tubules, Proximal; Maleimides; Membrane Proteins; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Quinazolines; Receptor, Notch1; RNA Interference; RNA, Small Interfering; Serrate-Jagged Proteins; Signal Transduction; Snail Family Transcription Factors; Transcription Factors; Tumor Suppressor Protein p53; Tyrphostins | 2014 |
Involvement of endogenous transforming growth factor-α in signal transduction pathway for interleukin-1β-induced hepatocyte proliferation.
Topics: Animals; Cell Cycle; Cell Proliferation; Cells, Cultured; Chromones; DNA; Dose-Response Relationship, Drug; Flavonoids; Hepatocytes; Interleukin 1 Receptor Antagonist Protein; Interleukin-1alpha; Interleukin-1beta; Male; MAP Kinase Signaling System; Morpholines; Quinazolines; Rats; Rats, Wistar; Signal Transduction; Sirolimus; Transforming Growth Factor alpha; Tyrphostins | 2014 |
The EGFR pathway regulates BCRP expression in NSCLC cells: role of erlotinib.
Topics: Adenosine; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Membrane; Chromones; Cytoplasm; Diketopiperazines; ErbB Receptors; Erlotinib Hydrochloride; Heterocyclic Compounds, 4 or More Rings; Humans; Lung Neoplasms; Morpholines; Neoplasm Proteins; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; Signal Transduction | 2014 |
CD40 ligand exhibits a direct antiviral effect on Herpes Simplex Virus type-1 infection via a PI3K-dependent, autophagy-independent mechanism.
Topics: Anthracenes; Antiviral Agents; Autophagy; Autophagy-Related Protein 5; Benzylamines; CD40 Ligand; Cell Line, Tumor; Cell Nucleus; Chromones; Herpes Simplex Virus Protein Vmw65; Herpesvirus 1, Human; Humans; JNK Mitogen-Activated Protein Kinases; Macrolides; Microtubule-Associated Proteins; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinazolines; RNA Interference; RNA, Small Interfering; Signal Transduction; Virus Replication | 2015 |
In Vitro Assessment of the Anticancer Potential of Evodiamine in Human Oral Cancer Cell Lines.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chromones; Humans; Mitochondria; Morpholines; Mouth Neoplasms; Myeloid Cell Leukemia Sequence 1 Protein; Phosphorylation; Plant Extracts; Poly(ADP-ribose) Polymerases; Protein Transport; Proto-Oncogene Proteins c-akt; Quinazolines | 2015 |
Reciprocal positive regulation between Cx26 and PI3K/Akt pathway confers acquired gefitinib resistance in NSCLC cells via GJIC-independent induction of EMT.
Topics: Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Communication; Cell Line, Tumor; Chromones; Connexin 26; Connexins; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; Female; Gap Junctions; Gefitinib; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Mice; Mice, Nude; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; Signal Transduction; Xenograft Model Antitumor Assays | 2015 |
MicroRNA-221 targets PTEN to reduce the sensitivity of cervical cancer cells to gefitinib through the PI3K/Akt signaling pathway.
Topics: 3' Untranslated Regions; Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Cell Survival; Chromones; Enzyme Inhibitors; Female; Gefitinib; HeLa Cells; Humans; MicroRNAs; Morpholines; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; PTEN Phosphohydrolase; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Uterine Cervical Neoplasms | 2016 |
Inhibitory effect of luteolin on the proliferation of human breast cancer cell lines induced by epidermal growth factor.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Chromones; Epidermal Growth Factor; ErbB Receptors; Humans; Luteolin; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Phosphatidylinositol 3-Kinases; Quinazolines; Tyrphostins | 2016 |
Phosphatidylinositol 3-Kinase/AKT Pathway Inhibition by Doxazosin Promotes Glioblastoma Cells Death, Upregulation of p53 and Triggers Low Neurotoxicity.
Topics: Animals; Antineoplastic Agents; Apoptosis; Astrocytes; Brain Neoplasms; Caspase 3; Cell Line, Tumor; Cell Proliferation; Chromones; Doxazosin; Enzyme Activation; G1 Phase Cell Cycle Checkpoints; Glioblastoma; Glycogen Synthase Kinase 3 beta; Hippocampus; Humans; Lapatinib; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; Rats; Rats, Wistar; Tumor Suppressor Protein p53 | 2016 |
ADAM17-siRNA inhibits MCF-7 breast cancer through EGFR-PI3K-AKT activation.
Topics: ADAM17 Protein; Animals; Benzamides; Breast Neoplasms; Chromones; Diphenylamine; ErbB Receptors; Female; Humans; MCF-7 Cells; Mice; Morpholines; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; RNA, Small Interfering; Signal Transduction; Tyrphostins; Xenograft Model Antitumor Assays | 2016 |
Integrated molecular pathway analysis informs a synergistic combination therapy targeting PTEN/PI3K and EGFR pathways for basal-like breast cancer.
Topics: Adult; Aged; Aged, 80 and over; Androstadienes; Animals; Breast Neoplasms; Chromones; Class I Phosphatidylinositol 3-Kinases; Drug Synergism; ErbB Receptors; Female; Gefitinib; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Humans; Mice; Middle Aged; Morpholines; Mutation; Phosphoric Monoester Hydrolases; Polyethylene Glycols; Protein Kinase Inhibitors; PTEN Phosphohydrolase; Quinazolines; Signal Transduction; Tissue Array Analysis; Xenograft Model Antitumor Assays | 2016 |
FOXM1 confers resistance to gefitinib in lung adenocarcinoma via a MET/AKT-dependent positive feedback loop.
Topics: Adenocarcinoma; Antineoplastic Agents; Cell Line, Tumor; Chromones; Drug Resistance, Neoplasm; Feedback, Physiological; Forkhead Box Protein M1; Gefitinib; Humans; Indoles; Lung Neoplasms; Morpholines; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-met; Quinazolines; RNA, Small Interfering; Signal Transduction; Sulfones | 2016 |
Influence and mechanism of 5-aminolevulinic acid-photodynamic therapy on the metastasis of esophageal carcinoma.
Topics: Aminolevulinic Acid; Animals; Apoptosis; Cell Line, Tumor; Cell Survival; Chromones; Down-Regulation; Drug Therapy, Combination; Esophageal Neoplasms; Female; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Morpholines; Photochemotherapy; Photosensitizing Agents; Protein Kinases; Quinazolines; Signal Transduction; Tyrphostins | 2017 |
Cooperative oncogenic effect and cell signaling crosstalk of co‑occurring HER2 and mutant PIK3CA in mammary epithelial cells.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chromones; Chromosomes, Human, Pair 17; Class I Phosphatidylinositol 3-Kinases; DNA Replication; Female; Gene Amplification; Genome-Wide Association Study; Humans; Mammary Glands, Human; Morpholines; Mutation; Quinazolines; Receptor, ErbB-2; Signal Transduction | 2017 |
Crosstalk between BCR-ABL and protease-activated receptor 1 (PAR1) suggests a novel target in chronic myeloid leukemia.
Topics: Adult; Aged; Antineoplastic Agents; Apoptosis; Case-Control Studies; Cell Line, Tumor; Chromones; Disease Progression; Dose-Response Relationship, Drug; Female; Flavonoids; Fusion Proteins, bcr-abl; Gene Expression Regulation, Leukemic; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Middle Aged; Morpholines; Myeloid Cells; Philadelphia Chromosome; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Quinazolines; Receptor, PAR-1; Signal Transduction; Treatment Outcome; Vascular Endothelial Growth Factor A | 2018 |
Phosphoinositide-3-kinase inhibition elevates ferritin level resulting depletion of labile iron pool and blocking of glioma cell proliferation.
Topics: Adenine; Animals; Brain Neoplasms; Cell Proliferation; Cells, Cultured; Chromones; Down-Regulation; Ferritins; Glioma; Humans; Iron; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Pyrimidinones; Quinazolines; Rats; Thiazolidinediones; Up-Regulation | 2019 |