quinazolines has been researched along with 1843u89 in 33 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 25 (75.76) | 18.2507 |
| 2000's | 8 (24.24) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cieśla, J; Maley, F; Montfort, WR; Weichsel, A | 1 |
| Erlichman, C; Mandelbaum, S; Mitrovski, B; Pressacco, J | 1 |
| Banks, SD; Barrett, LL; Dickerson, S; Pendergast, W; Smith, GK; Waters, KA | 1 |
| Dev, IK; Dickerson, SH; Duch, DS; Ferone, R; Pendergast, W; Smith, GK | 1 |
| Erlichman, C; Mitrovski, B | 1 |
| Dallas, WS; Dev, IK; Ferone, R; Hanlon, M; McKee, DD; Yates, BB | 1 |
| Banks, S; Dev, IK; Dickerson, SH; Duch, DS; Ferone, R; Heath, LS; Humphreys, J; Knick, V; Pendergast, W; Singer, S | 1 |
| Amyx, H; Boytos, CM; Duch, DS; Ferone, R; Smith, GK; Wilson, HR | 1 |
| Calvert, AH; Jackman, AL | 1 |
| Chen, CH; Davis, RA; Maley, F | 1 |
| Ferone, R; Hanlon, MH | 1 |
| Stout, TJ; Stroud, RM | 1 |
| Montfort, WR; Weichsel, A | 1 |
| Bertino, JR; Ercikan, E; Gorlick, R; Longo, GS; Tong, WP | 1 |
| Jansen, G; Peters, GJ; Pinedo, HM; Telleman, F; van der Wilt, CL; van Triest, B | 1 |
| Dolnick, BJ; Lu, K; Rustum, YM; Yin, MB | 1 |
| Takimoto, CH | 1 |
| Hannun, YA; Jayadev, S; Laethem, RM; Sexton, CJ; Smith, GK; Strum, JC; Sundseth, R | 1 |
| Banerjee, D; Bertino, JR; Ercikan-Abali, EA; Liu-Chen, X; Maley, F; Tong, Y; Zhao, SC | 1 |
| Bertino, JR; Li, WW; Tong, WP | 1 |
| Assaraf, YG; Borst, P; Broxterman, HJ; Hooijberg, JH; Jansen, G; Kool, M; Noordhuis, P; Peters, GJ; Pinedo, HM; Scheper, RJ | 1 |
| Jansen, G; Peters, GJ; Pinedo, HM; Smid, K; Smitskamp-Wilms, E | 1 |
| Newell, DR | 1 |
| Danenberg, PV; Malli, H; Swenson, S | 1 |
| Jiang, L; Lee, PC; Rathod, PK; White, J | 1 |
| Kuiper, CM; Peters, GJ; van der Wilt, CL | 1 |
| Aherne, GW; Brunton, L; Jackman, AL; Monaghan, P; Titley, J; Valenti, M; Welsh, SJ | 1 |
| Assaraf, YG; Drori, S; Jansen, G; Mauritz, R; Peters, GJ | 1 |
| Burris, H; Goetz, A; Hohneker, JA; Johnson, TR; Lampkin, T; Rowinsky, EK; Sailstad, J; Schwartz, G; Smetzer, L; Von Hoff, DD | 1 |
| Callender, MA; Chu, E; Farrell, MP; Schmitz, JC | 1 |
| Abbott, E; Brown, EN; Colagiovanni, DB; Desjardins, J; Drolet, DW; Emerson, DL | 1 |
| Fukushima, M; Hoogeland, MF; Peters, GJ; Temmink, OH | 1 |
| Aispuro-Hernandez, E; Arvizu-Flores, AA; Garcia-Orozco, KD; Maley, F; Rojo-Domínguez, A; Sotelo-Mundo, RR; Valenzuela-Soto, E; Varela-Romero, A; Velazquez-Contreras, EF; Yepiz-Plascencia, G | 1 |
5 review(s) available for quinazolines and 1843u89
| Article | Year |
|---|---|
Folate-based thymidylate synthase inhibitors as anticancer drugs.
Topics: Antineoplastic Agents; Enzyme Inhibitors; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Humans; Indoles; Isoindoles; Pemetrexed; Quinazolines; Thiophenes; Thymidylate Synthase | 1995 |
Antifolates in clinical development.
Topics: Aminopterin; Animals; Antimetabolites, Antineoplastic; Clinical Trials as Topic; Drug Design; Enzyme Inhibitors; Folic Acid Antagonists; Glutamates; Guanine; Humans; Indoles; Isoindoles; Pemetrexed; Pyrimidines; Quinazolines; Tetrahydrofolates; Thiophenes; Thymidylate Synthase | 1997 |
Clinical pharmacokinetics of antitumor antifolates.
Topics: Antimetabolites, Antineoplastic; Enzyme Inhibitors; Folic Acid; Folic Acid Antagonists; Humans; Indoles; Isoindoles; Methotrexate; Quinazolines; Tetrahydrofolates; Thiophenes; Thymidylate Synthase | 1999 |
Thymidylate synthase inhibitors.
Topics: Animals; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Enzyme Inhibitors; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Humans; Indoles; Isoindoles; Pemetrexed; Quinazolines; Thiophenes; Thymidylate Synthase | 1999 |
Thymidylate synthase inhibitors as anticancer agents: from bench to bedside.
Topics: Antineoplastic Agents; Enzyme Inhibitors; Humans; Indoles; Isoindoles; Neoplasms; Quinazolines; Randomized Controlled Trials as Topic; Thiophenes; Thymidylate Synthase | 2003 |
1 trial(s) available for quinazolines and 1843u89
| Article | Year |
|---|---|
A phase I and pharmacokinetic study of 1843U89, a noncompetitive inhibitor of thymidylate synthase, in patients with advanced solid malignancies.
Topics: Adult; Aged; Antineoplastic Agents; Area Under Curve; Dose-Response Relationship, Drug; Enzyme Inhibitors; Exanthema; Female; Folic Acid; Humans; Indoles; Infusions, Intravenous; Isoindoles; Male; Middle Aged; Mouth Mucosa; Neoplasms; Neutropenia; Quinazolines; Stomatitis; Thymidylate Synthase | 2001 |
27 other study(ies) available for quinazolines and 1843u89
| Article | Year |
|---|---|
Promotion of purine nucleotide binding to thymidylate synthase by a potent folate analogue inhibitor, 1843U89.
Topics: Circular Dichroism; Crystallography, X-Ray; Escherichia coli; Folic Acid; Hydrogen Bonding; Indoles; Isoindoles; Models, Molecular; Molecular Sequence Data; Purine Nucleotides; Quinazolines; Recombinant Proteins; Thymidylate Synthase | 1995 |
Biochemical effects of folate-based inhibitors of thymidylate synthase in MGH-U1 cells.
Topics: Cell Survival; Deoxyuracil Nucleotides; Deoxyuridine; Folic Acid; Folic Acid Antagonists; Glutamates; Humans; In Vitro Techniques; Indoles; Isoindoles; Quinazolines; Structure-Activity Relationship; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 1994 |
Destruction of WiDr multicellular tumor spheroids with the novel thymidylate synthase inhibitor 1843U89 at physiological thymidine concentrations.
Topics: Antineoplastic Agents; Carcinoma; Cell Division; Colonic Neoplasms; Humans; Indoles; Isoindoles; Methotrexate; Quinazolines; Thymidine; Thymidylate Synthase; Time Factors; Tumor Cells, Cultured | 1994 |
Benzo[f]quinazoline inhibitors of thymidylate synthase: methyleneamino-linked aroylglutamate derivatives.
Topics: Adenocarcinoma; Antineoplastic Agents; Breast Neoplasms; Colonic Neoplasms; Glutamates; Humans; Indoles; Isoindoles; Quinazolines; Structure-Activity Relationship; Thymidylate Synthase; Tumor Cells, Cultured | 1994 |
Comparative cytotoxicity of folate-based inhibitors of thymidylate synthase and 5-fluorouracil +/- leucovorin in MGH-U1 cells.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Survival; Drug Screening Assays, Antitumor; Fluorouracil; Folic Acid; Glutamates; Humans; Indoles; Isoindoles; Leucovorin; Quinazolines; Thymidylate Synthase; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 1994 |
Mode of binding of folate analogs to thymidylate synthase. Evidence for two asymmetric but interactive substrate binding sites.
Topics: Binding Sites; Carbon Radioisotopes; Deoxyuracil Nucleotides; Folic Acid; Folic Acid Antagonists; Humans; Indoles; Isoindoles; Kinetics; Macromolecular Substances; Mathematics; Protein Binding; Quinazolines; Structure-Activity Relationship; Thymidylate Synthase | 1994 |
Biochemical and cellular pharmacology of 1843U89, a novel benzoquinazoline inhibitor of thymidylate synthase.
Topics: Animals; Binding, Competitive; Breast Neoplasms; Cell Division; Colonic Neoplasms; Female; Humans; Indoles; Isoindoles; Leucovorin; Leukemia L1210; Leukemia, T-Cell; Methotrexate; Quinazolines; Structure-Activity Relationship; Subrenal Capsule Assay; Tetrahydrofolates; Thymidylate Synthase | 1993 |
Enhanced antitumor activity for the thymidylate synthase inhibitor 1843U89 through decreased host toxicity with oral folic acid.
Topics: Animals; Body Weight; Dogs; Dose-Response Relationship, Drug; Enzyme Inhibitors; Folic Acid; Humans; Indoles; Intestinal Diseases; Isoindoles; Leucovorin; Mice; Neoplasms, Experimental; Osteosarcoma; Quinazolines; Thymidylate Synthase; Tumor Cells, Cultured | 1995 |
Thermodynamic stabilization of nucleotide binding to thymidylate synthase by a potent benzoquinazoline folate analogue inhibitor.
Topics: Calorimetry, Differential Scanning; Folic Acid Antagonists; Indoles; Isoindoles; Nucleotides; Protein Denaturation; Quinazolines; Substrate Specificity; Thermodynamics; Thymidylate Synthase | 1996 |
In vitro uptake, anabolism, and cellular retention of 1843U89 and other benzoquinazoline inhibitors of thymidylate synthase.
Topics: Animals; Carcinoma; Enzyme Inhibitors; Folic Acid; Folic Acid Antagonists; Humans; Indoles; Intestinal Neoplasms; Isoindoles; Leucovorin; Liver; Metabolic Clearance Rate; Peptide Synthases; Polyglutamic Acid; Quinazolines; Swine; Thymidylate Synthase; Tumor Cells, Cultured | 1996 |
The complex of the anti-cancer therapeutic, BW1843U89, with thymidylate synthase at 2.0 A resolution: implications for a new mode of inhibition.
Topics: Antineoplastic Agents; Binding Sites; Binding, Competitive; Crystallography, X-Ray; Deoxyuracil Nucleotides; Drug Design; Enzyme Inhibitors; Escherichia coli; Folic Acid Antagonists; Indoles; Isoindoles; Models, Molecular; Molecular Structure; Protein Binding; Protein Conformation; Quinazolines; Thymidylate Synthase | 1996 |
Ligand-induced distortion of an active site in thymidylate synthase upon binding anticancer drug 1843U89.
Topics: Antineoplastic Agents; Binding Sites; Crystallography; Indoles; Isoindoles; Ligands; Protein Conformation; Quinazolines; Structure-Activity Relationship; Thymidylate Synthase | 1995 |
Disparate affinities of antifolates for folylpolyglutamate synthetase from human leukemia cells.
Topics: Acute Disease; Antimetabolites, Antineoplastic; Drug Resistance, Neoplasm; Enzyme Inhibitors; Folic Acid Antagonists; HL-60 Cells; Humans; Indoles; Isoindoles; Kinetics; Leukemia, Myeloid; Methotrexate; Neoplasm Proteins; Organ Specificity; Peptide Synthases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Quinazolines; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 1997 |
Cross-resistance to antifolates in multidrug resistant cell lines with P-glycoprotein or multidrug resistance protein expression.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Cell Division; Drug Resistance, Multiple; Fluorodeoxyuridylate; Fluorouracil; Folic Acid Antagonists; Gene Expression Regulation; Humans; Indoles; Isoindoles; Methotrexate; Peptide Synthases; Polymerase Chain Reaction; Quinazolines; RNA, Messenger; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 1997 |
Recent advances in the study of rTS proteins. rTS expression during growth and in response to thymidylate synthase inhibitors in human tumor cells.
Topics: Blotting, Western; Cell Division; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Floxuridine; Folic Acid Antagonists; Gene Expression Regulation, Neoplastic; Humans; Hydro-Lyases; Indoles; Isoindoles; Protein Biosynthesis; Proteins; Quinazolines; Racemases and Epimerases; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 1997 |
Increases in neutral, Mg2+-dependent and acidic, Mg2+-independent sphingomyelinase activities precede commitment to apoptosis and are not a consequence of caspase 3-like activity in Molt-4 cells in response to thymidylate synthase inhibition by GW1843.
Topics: Apoptosis; Caspase 3; Caspases; Ceramides; Cysteine Endopeptidases; Diglycerides; Enzyme Inhibitors; Enzyme Precursors; Humans; Indoles; Isoindoles; Leukemia, T-Cell; Magnesium; Quinazolines; Sphingomyelin Phosphodiesterase; Thymidylate Synthase; Tumor Cells, Cultured | 1998 |
Probing the folate-binding site of human thymidylate synthase by site-directed mutagenesis. Generation of mutants that confer resistance to raltitrexed, Thymitaq, and BW1843U89.
Topics: Animals; Antimetabolites, Antineoplastic; Binding Sites; Bone Marrow Cells; Drug Resistance; Folic Acid; Folic Acid Antagonists; Granulocytes; Humans; Indoles; Isoindoles; Isoleucine; Kinetics; Macrophages; Mice; Models, Molecular; Mutagenesis, Site-Directed; Quinazolines; Recombinant Proteins; Stem Cells; Thiophenes; Thymidylate Synthase | 1998 |
Antitumor activity of antifolate inhibitors of thymidylate and purine synthesis in human soft tissue sarcoma cell lines with intrinsic resistance to methotrexate.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Biological Transport; Biotransformation; Cell Division; Cell Survival; Drug Resistance, Neoplasm; Folic Acid Antagonists; Humans; Indoles; Isoindoles; Kinetics; Methotrexate; Purines; Quinazolines; Sarcoma; Tetrahydrofolates; Thiophenes; Thymidine Monophosphate; Tumor Cells, Cultured | 1995 |
Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2.
Topics: Adenosine Triphosphate; Antimetabolites, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Folic Acid Antagonists; Glutamates; Humans; Indoles; Isoindoles; Methotrexate; Ovarian Neoplasms; Quinazolines; Thiophenes; Transfection; Tumor Cells, Cultured | 1999 |
Determinants of activity of the antifolate thymidylate synthase inhibitors Tomudex (ZD1694) and GW1843U89 against mono- and multilayered colon cancer cell lines under folate-restricted conditions.
Topics: Blotting, Western; Cell Cycle; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Folic Acid Antagonists; Humans; Immunohistochemistry; Indoles; Inhibitory Concentration 50; Isoindoles; Methotrexate; Quinazolines; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 1999 |
Potent and selective activity of a combination of thymidine and 1843U89, a folate-based thymidylate synthase inhibitor, against Plasmodium falciparum.
Topics: Animals; Cell Division; Enzyme Inhibitors; Erythrocytes; Folic Acid Antagonists; Indoles; Isoindoles; Kinetics; Leukemia L1210; Mice; Plasmodium falciparum; Quinazolines; Thymidine; Thymidylate Synthase | 2000 |
Combination studies of antifolates with 5-fluorouracil in colon cancer cell lines.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Colonic Neoplasms; DNA Damage; Fluorouracil; Folic Acid Antagonists; Glutamates; Guanine; Humans; Indoles; Isoindoles; Pemetrexed; Quinazolines; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 1999 |
Comparison of thymidylate synthase (TS) protein up-regulation after exposure to TS inhibitors in normal and tumor cell lines and tissues.
Topics: Analysis of Variance; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Blotting, Western; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Fibroblasts; Flow Cytometry; Fluorouracil; Glutamates; Guanine; Humans; Indoles; Inhibitory Concentration 50; Isoindoles; Mice; Mice, Inbred DBA; Microscopy, Confocal; Neoplasm Transplantation; Pemetrexed; Quinazolines; Thiophenes; Thymidylate Synthase; Time Factors; Tumor Cells, Cultured; Up-Regulation | 2000 |
Clustering of mutations in the first transmembrane domain of the human reduced folate carrier in GW1843U89-resistant leukemia cells with impaired antifolate transport and augmented folate uptake.
Topics: Antimetabolites, Antineoplastic; Biological Transport; Blotting, Northern; Blotting, Southern; Blotting, Western; Carrier Proteins; Cell Division; Cell Membrane; Chlorides; DNA Mutational Analysis; DNA, Complementary; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Enzyme Inhibitors; Exons; Folic Acid; Folic Acid Antagonists; Humans; Indoles; Inhibitory Concentration 50; Isoindoles; Kinetics; Leucovorin; Leukemia; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Mutagenesis, Site-Directed; Mutation; Polymorphism, Single-Stranded Conformational; Protein Structure, Secondary; Protein Structure, Tertiary; Quinazolines; Recombinant Proteins; Reduced Folate Carrier Protein; Thymidylate Synthase; Time Factors; Transfection; Trimetrexate; Tumor Cells, Cultured | 2000 |
Pharmacokinetics, safety, and efficacy of a liposome encapsulated thymidylate synthase inhibitor, OSI-7904L [(S)-2-[5-[(1,2-dihydro-3-methyl-1-oxobenzo[f]quinazolin-9-yl)methyl]amino-1-oxo-2-isoindolynl]-glutaric acid] in mice.
Topics: Animals; Antineoplastic Agents; Biological Availability; Carbon Radioisotopes; Disease Models, Animal; Drug Carriers; Drug Delivery Systems; Enzyme Inhibitors; Humans; Indoles; Isoindoles; Liposomes; Metabolic Clearance Rate; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Neoplasms, Experimental; Quinazolines; Thymidylate Synthase; Tissue Distribution; Treatment Outcome; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2004 |
Low folate conditions may enhance the interaction of trifluorothymidine with antifolates in colon cancer cells.
Topics: Antimetabolites; Colonic Neoplasms; DNA Damage; Drug Interactions; Folic Acid; Folic Acid Antagonists; Homeostasis; Humans; Indoles; Isoindoles; Quinazolines; Thiophenes; Trifluridine; Tumor Cells, Cultured | 2006 |
Functional identity of the active sites of crustacean and viral thymidylate synthases.
Topics: Amino Acid Sequence; Animals; Base Sequence; Catalytic Domain; Cloning, Molecular; Deoxyuracil Nucleotides; Folic Acid; Folic Acid Antagonists; Isoindoles; Kinetics; Models, Molecular; Molecular Sequence Data; Penaeidae; Phylogeny; Quinazolines; Sequence Alignment; Thymidylate Synthase; White spot syndrome virus 1 | 2009 |