Page last updated: 2024-09-02

quinaprilat and losartan

quinaprilat has been researched along with losartan in 7 studies

Compound Research Comparison

Studies
(quinaprilat)
Trials
(quinaprilat)
Recent Studies (post-2010)
(quinaprilat)
Studies
(losartan)
Trials
(losartan)
Recent Studies (post-2010) (losartan)
922347,2311,2452,118

Protein Interaction Comparison

ProteinTaxonomyquinaprilat (IC50)losartan (IC50)
Bile salt export pumpHomo sapiens (human)9.01
Cytochrome P450 2C9 Homo sapiens (human)2.882
Angiotensin-converting enzyme Homo sapiens (human)0.019
Atrial natriuretic peptide receptor 3Homo sapiens (human)0.0018
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)0.019
Type-1A angiotensin II receptor Rattus norvegicus (Norway rat)0.0247
Type-1B angiotensin II receptorRattus norvegicus (Norway rat)0.0234
Adenosine receptor A2aRattus norvegicus (Norway rat)0.0032
Type-1 angiotensin II receptorHomo sapiens (human)0.047
Type-1 angiotensin II receptorOryctolagus cuniculus (rabbit)0.025
Type-2 angiotensin II receptorRattus norvegicus (Norway rat)0.0118
Type-2 angiotensin II receptorHomo sapiens (human)0.019
Platelet glycoprotein VIHomo sapiens (human)4
Solute carrier organic anion transporter family member 1B3Homo sapiens (human)1.1481
Type-1 angiotensin II receptorCavia porcellus (domestic guinea pig)0.018
Solute carrier organic anion transporter family member 1B1Homo sapiens (human)0.2884

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (14.29)18.2507
2000's4 (57.14)29.6817
2010's1 (14.29)24.3611
2020's1 (14.29)2.80

Authors

AuthorsStudies
Lombardo, F; Obach, RS; Waters, NJ1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Allegrini, PR; Buser, PT; Hornstein, PS; Zaugg, CE; Zhu, P1
Appenroth, D; Beutinger, R; Fleck, C; Lupp, A1
Cosentino, F; Delli Gatti, C; Eto, M; Kouroedov, A; Lüscher, TF; Osto, E; Shaw, S; Volpe, M1
Balachandran, K; Ozkizilcik, A; Patel, S; Sysavanh, F; Tandon, I1

Other Studies

7 other study(ies) available for quinaprilat and losartan

ArticleYear
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Bradykinin-dependent cardioprotective effects of losartan against ischemia and reperfusion in rat hearts.
    Journal of cardiovascular pharmacology, 1999, Volume: 33, Issue:5

    Topics: Adenosine Triphosphate; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin; Coronary Circulation; In Vitro Techniques; Isoquinolines; Losartan; Male; Myocardial Reperfusion Injury; Myocardium; Phosphocreatine; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Tetrahydroisoquinolines; Ventricular Function, Left; Ventricular Pressure

1999
Effects of a therapy with losartan and quinaprilat on the progression of chronic renal failure in rats after a single dose of uranyl nitrate or 5/6 nephrectomy.
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 2003, Volume: 54, Issue:5-6

    Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Disease Models, Animal; Disease Progression; Female; Hydroxyproline; Injections, Intraperitoneal; Kidney Failure, Chronic; Losartan; Nephrectomy; p-Aminohippuric Acid; Proteinuria; Rats; Rats, Wistar; Tetrahydroisoquinolines; Uranyl Nitrate

2003
Pulsatile stretch induces release of angiotensin II and oxidative stress in human endothelial cells: effects of ACE inhibition and AT1 receptor antagonism.
    Clinical and experimental hypertension (New York, N.Y. : 1993), 2008, Volume: 30, Issue:7

    Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Biomechanical Phenomena; Cells, Cultured; Endothelial Cells; Hemorheology; Humans; Losartan; Models, Biological; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Pulsatile Flow; Renin-Angiotensin System; Stress, Mechanical; Superoxides; Tetrahydroisoquinolines

2008
Local Renin-Angiotensin System Signaling Mediates Cellular Function of Aortic Valves.
    Annals of biomedical engineering, 2021, Volume: 49, Issue:12

    Topics: Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Aortic Valve; Cells, Cultured; Fluorescent Antibody Technique; Losartan; Myofibroblasts; Peptidyl-Dipeptidase A; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Swine; Tetrahydroisoquinolines

2021