Page last updated: 2024-09-02

quinaprilat and enalaprilat anhydrous

quinaprilat has been researched along with enalaprilat anhydrous in 12 studies

Compound Research Comparison

Studies
(quinaprilat)
Trials
(quinaprilat)
Recent Studies (post-2010)
(quinaprilat)
Studies
(enalaprilat anhydrous)
Trials
(enalaprilat anhydrous)
Recent Studies (post-2010) (enalaprilat anhydrous)
9223484610976

Protein Interaction Comparison

ProteinTaxonomyquinaprilat (IC50)enalaprilat anhydrous (IC50)
Angiotensin-converting enzymeMus musculus (house mouse)0.0115
Angiotensin-converting enzyme Homo sapiens (human)0.2405
Angiotensin-converting enzymeOryctolagus cuniculus (rabbit)0.0054
Type-2 angiotensin II receptorRattus norvegicus (Norway rat)0.0012
Angiotensin-converting enzymeRattus norvegicus (Norway rat)0.0036
Angiotensin-converting enzyme 2 Homo sapiens (human)0.0024

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19902 (16.67)18.7374
1990's4 (33.33)18.2507
2000's4 (33.33)29.6817
2010's2 (16.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Codding, PW; Hausin, RJ1
Cohen, D; Essenburg, AD; Kaplan, HR; Roark, WH; Tinney, FJ1
Blankley, CJ; Cohen, DM; Essenburg, AD; Fleming, RW; Hinkley, JM; Hoefle, ML; Holmes, A; Klutchko, S; Nordin, I; Werner, AE1
Lombardo, F; Obach, RS; Waters, NJ1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Bree, F; Chevillard, C; Corvol, P; Hamon, G; Jouquey, S; Mathieu, MN; Stepniewski, JP; Tillement, JP1
Bumpus, FM; Husain, A; Kinoshita, A; Urata, H1
Abiko, Y; Hara, A; Hashizume, H; Ma, H; Yazawa, K1
de Haan, CH; de Leeuw, PW; Fuss-Lejeune, MJ; Houben, AJ; Kroon, AA1
Bao, Y; Bernard, SA; Colton, T; Lazar, HL; Rivers, S1
Backman, JT; Holmberg, MT; Launiainen, T; Neuvonen, PJ; Niemi, M; Tarkiainen, EK; Tornio, A1

Trials

2 trial(s) available for quinaprilat and enalaprilat anhydrous

ArticleYear
Quinaprilat-induced vasodilatation in forearm vasculature of patients with essential hypertension: comparison with enalaprilat.
    Cardiovascular drugs and therapy, 2000, Volume: 14, Issue:6

    Topics: Aged; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Enalaprilat; Forearm; Heart Rate; Humans; Hypertension; Isoquinolines; Male; Middle Aged; Peptidyl-Dipeptidase A; Regional Blood Flow; Tetrahydroisoquinolines; Vasodilation

2000
Effect of carboxylesterase 1 c.428G > A single nucleotide variation on the pharmacokinetics of quinapril and enalapril.
    British journal of clinical pharmacology, 2015, Volume: 80, Issue:5

    Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Carboxylic Ester Hydrolases; Cross-Over Studies; Enalapril; Enalaprilat; Female; Genotype; Healthy Volunteers; Heart Rate; Humans; Male; Polymorphism, Single Nucleotide; Quinapril; Tetrahydroisoquinolines; Young Adult

2015

Other Studies

10 other study(ies) available for quinaprilat and enalaprilat anhydrous

ArticleYear
Molecular and crystal structures of MDL27,467A hydrochloride and quinapril hydrochloride, two ester derivatives of potent angiotensin converting enzyme inhibitors.
    Journal of medicinal chemistry, 1991, Volume: 34, Issue:2

    Topics: Angiotensin-Converting Enzyme Inhibitors; Benzazepines; Crystallography; Isoquinolines; Pyridones; Quinapril; Tetrahydroisoquinolines

1991
Synthesis and biological activity of modified peptide inhibitors of angiotensin-converting enzyme.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:9

    Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Chemical Phenomena; Chemistry; Dipeptides; Enalapril; Guinea Pigs; Hypertension, Renal; Indoles; Isoquinolines; Quinapril; Rats; Structure-Activity Relationship; Tetrahydroisoquinolines

1985
Synthesis of novel angiotensin converting enzyme inhibitor quinapril and related compounds. A divergence of structure-activity relationships for non-sulfhydryl and sulfhydryl types.
    Journal of medicinal chemistry, 1986, Volume: 29, Issue:10

    Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Isoquinolines; Male; Molecular Conformation; Quinapril; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Sulfhydryl Compounds; Tetrahydroisoquinolines

1986
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Compared properties of trandolapril, enalapril, and their diacid metabolites.
    Journal of cardiovascular pharmacology, 1994, Volume: 23 Suppl 4

    Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Enalapril; Enalaprilat; Indoles; Isoquinolines; Male; Peptidyl-Dipeptidase A; Rats; Rats, Inbred SHR; Solubility; Tetrahydroisoquinolines

1994
Measurement of angiotensin I converting enzyme inhibition in the heart.
    Circulation research, 1993, Volume: 73, Issue:1

    Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Captopril; Cricetinae; Dipeptides; Enalaprilat; Humans; Isoquinolines; Lisinopril; Male; Mesocricetus; Papillary Muscles; Tetrahydroisoquinolines

1993
Protective effect of quinaprilat, an active metabolite of quinapril, on Ca2+-overload induced by lysophosphatidylcholine in isolated rat cardiomyocytes.
    Japanese journal of pharmacology, 1999, Volume: 79, Issue:1

    Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin; Calcium; Cell Size; Creatine Kinase; Enalapril; Enalaprilat; Isoquinolines; Lysophosphatidylcholines; Male; Micelles; Myocardium; Propranolol; Quinapril; Rats; Rats, Sprague-Dawley; Tetrahydroisoquinolines; Vasodilator Agents

1999
High tissue affinity angiotensin-converting enzyme inhibitors improve endothelial function and reduce infarct size.
    The Annals of thoracic surgery, 2001, Volume: 72, Issue:2

    Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Enalaprilat; Endothelium, Vascular; Infusions, Intravenous; Isoquinolines; Myocardial Contraction; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Necrosis; Swine; Tetrahydroisoquinolines

2001