Page last updated: 2024-09-02

quinaprilat and enalapril

quinaprilat has been researched along with enalapril in 8 studies

Compound Research Comparison

Studies (quinaprilat)	Trials (quinaprilat)	Recent Studies (post-2010) (quinaprilat)	Studies (enalapril)	Trials (enalapril)	Recent Studies (post-2010) (enalapril)
92	23	4	6,311	1,924	859

Protein Interaction Comparison

Protein	Taxonomy	enalapril (IC50)
Angiotensin-converting enzyme	Homo sapiens (human)	0.3536
Angiotensin-converting enzyme	Oryctolagus cuniculus (rabbit)	2.7083
Type-2 angiotensin II receptor	Rattus norvegicus (Norway rat)	1.2
Angiotensin-converting enzyme	Rattus norvegicus (Norway rat)	0.14
Angiotensin-converting enzyme 2	Homo sapiens (human)	0.14

Research

Studies (8)

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (25.00)	18.7374
1990's	4 (50.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	2 (25.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Codding, PW; Hausin, RJ	1
Cohen, D; Essenburg, AD; Kaplan, HR; Roark, WH; Tinney, FJ	1
Blankley, CJ; Cohen, DM; Essenburg, AD; Fleming, RW; Hinkley, JM; Hoefle, ML; Holmes, A; Klutchko, S; Nordin, I; Werner, AE	1
Bree, F; Chevillard, C; Corvol, P; Hamon, G; Jouquey, S; Mathieu, MN; Stepniewski, JP; Tillement, JP	1
Abiko, Y; Hara, A; Hashizume, H; Ma, H; Yazawa, K	1
Akarawut, W; Lin, CJ; Smith, DE	1
Briggs, JP; Chen, L; Chen, M; Eisner, C; Gomez, RA; Huang, Y; Kim, SM; Li, L; Mizel, D; Oppermann, M; Schnermann, J; Sequeira Lopez, ML; Weinstein, LS	1
Backman, JT; Holmberg, MT; Launiainen, T; Neuvonen, PJ; Niemi, M; Tarkiainen, EK; Tornio, A	1

Trials

1 trial(s) available for quinaprilat and enalapril

Article	Year
Effect of carboxylesterase 1 c.428G > A single nucleotide variation on the pharmacokinetics of quinapril and enalapril. British journal of clinical pharmacology, 2015, Volume: 80, Issue:5 Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Carboxylic Ester Hydrolases; Cross-Over Studies; Enalapril; Enalaprilat; Female; Genotype; Healthy Volunteers; Heart Rate; Humans; Male; Polymorphism, Single Nucleotide; Quinapril; Tetrahydroisoquinolines; Young Adult	2015

Article

Year

Effect of carboxylesterase 1 c.428G > A single nucleotide variation on the pharmacokinetics of quinapril and enalapril.

British journal of clinical pharmacology, 2015, Volume: 80, Issue:5

Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Carboxylic Ester Hydrolases; Cross-Over Studies; Enalapril; Enalaprilat; Female; Genotype; Healthy Volunteers; Heart Rate; Humans; Male; Polymorphism, Single Nucleotide; Quinapril; Tetrahydroisoquinolines; Young Adult

2015

Other Studies

7 other study(ies) available for quinaprilat and enalapril

Article	Year
Molecular and crystal structures of MDL27,467A hydrochloride and quinapril hydrochloride, two ester derivatives of potent angiotensin converting enzyme inhibitors. Journal of medicinal chemistry, 1991, Volume: 34, Issue:2 Topics: Angiotensin-Converting Enzyme Inhibitors; Benzazepines; Crystallography; Isoquinolines; Pyridones; Quinapril; Tetrahydroisoquinolines	1991
Synthesis and biological activity of modified peptide inhibitors of angiotensin-converting enzyme. Journal of medicinal chemistry, 1985, Volume: 28, Issue:9 Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Chemical Phenomena; Chemistry; Dipeptides; Enalapril; Guinea Pigs; Hypertension, Renal; Indoles; Isoquinolines; Quinapril; Rats; Structure-Activity Relationship; Tetrahydroisoquinolines	1985
Synthesis of novel angiotensin converting enzyme inhibitor quinapril and related compounds. A divergence of structure-activity relationships for non-sulfhydryl and sulfhydryl types. Journal of medicinal chemistry, 1986, Volume: 29, Issue:10 Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Isoquinolines; Male; Molecular Conformation; Quinapril; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Sulfhydryl Compounds; Tetrahydroisoquinolines	1986
Compared properties of trandolapril, enalapril, and their diacid metabolites. Journal of cardiovascular pharmacology, 1994, Volume: 23 Suppl 4 Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Enalapril; Enalaprilat; Indoles; Isoquinolines; Male; Peptidyl-Dipeptidase A; Rats; Rats, Inbred SHR; Solubility; Tetrahydroisoquinolines	1994
Protective effect of quinaprilat, an active metabolite of quinapril, on Ca2+-overload induced by lysophosphatidylcholine in isolated rat cardiomyocytes. Japanese journal of pharmacology, 1999, Volume: 79, Issue:1 Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin; Calcium; Cell Size; Creatine Kinase; Enalapril; Enalaprilat; Isoquinolines; Lysophosphatidylcholines; Male; Micelles; Myocardium; Propranolol; Quinapril; Rats; Rats, Sprague-Dawley; Tetrahydroisoquinolines; Vasodilator Agents	1999
Competitive inhibition of glycylsarcosine transport by enalapril in rabbit renal brush border membrane vesicles: interaction of ACE inhibitors with high-affinity H+/peptide symporter. Pharmaceutical research, 1999, Volume: 16, Issue:5 Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Binding, Competitive; Captopril; Carrier Proteins; Cell Membrane; Dipeptides; Dose-Response Relationship, Drug; Enalapril; Fosinopril; Isoquinolines; Kidney; Kinetics; Lipid Metabolism; Lipids; Lisinopril; Male; Microvilli; Peptide Transporter 1; Quinapril; Rabbits; Ramipril; Symporters; Tetrahydroisoquinolines	1999
Stimulation of renin secretion by angiotensin II blockade is Gsalpha-dependent. Journal of the American Society of Nephrology : JASN, 2010, Volume: 21, Issue:6 Topics: Adenylyl Cyclases; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzimidazoles; Biphenyl Compounds; Captopril; Catecholamines; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enalapril; Female; GTP-Binding Protein alpha Subunits, Gs; Juxtaglomerular Apparatus; Male; Mice; Mice, Knockout; Models, Animal; Nitric Oxide; Prostaglandins; Renin; Signal Transduction; Tetrahydroisoquinolines; Tetrazoles	2010