Page last updated: 2024-09-02

quinaprilat and enalapril

quinaprilat has been researched along with enalapril in 8 studies

Compound Research Comparison

Studies
(quinaprilat)
Trials
(quinaprilat)
Recent Studies (post-2010)
(quinaprilat)
Studies
(enalapril)
Trials
(enalapril)
Recent Studies (post-2010) (enalapril)
922346,3111,924859

Protein Interaction Comparison

ProteinTaxonomyquinaprilat (IC50)enalapril (IC50)
Angiotensin-converting enzyme Homo sapiens (human)0.3536
Angiotensin-converting enzymeOryctolagus cuniculus (rabbit)2.7083
Type-2 angiotensin II receptorRattus norvegicus (Norway rat)1.2
Angiotensin-converting enzymeRattus norvegicus (Norway rat)0.14
Angiotensin-converting enzyme 2 Homo sapiens (human)0.14

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19902 (25.00)18.7374
1990's4 (50.00)18.2507
2000's0 (0.00)29.6817
2010's2 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Codding, PW; Hausin, RJ1
Cohen, D; Essenburg, AD; Kaplan, HR; Roark, WH; Tinney, FJ1
Blankley, CJ; Cohen, DM; Essenburg, AD; Fleming, RW; Hinkley, JM; Hoefle, ML; Holmes, A; Klutchko, S; Nordin, I; Werner, AE1
Bree, F; Chevillard, C; Corvol, P; Hamon, G; Jouquey, S; Mathieu, MN; Stepniewski, JP; Tillement, JP1
Abiko, Y; Hara, A; Hashizume, H; Ma, H; Yazawa, K1
Akarawut, W; Lin, CJ; Smith, DE1
Briggs, JP; Chen, L; Chen, M; Eisner, C; Gomez, RA; Huang, Y; Kim, SM; Li, L; Mizel, D; Oppermann, M; Schnermann, J; Sequeira Lopez, ML; Weinstein, LS1
Backman, JT; Holmberg, MT; Launiainen, T; Neuvonen, PJ; Niemi, M; Tarkiainen, EK; Tornio, A1

Trials

1 trial(s) available for quinaprilat and enalapril

ArticleYear
Effect of carboxylesterase 1 c.428G > A single nucleotide variation on the pharmacokinetics of quinapril and enalapril.
    British journal of clinical pharmacology, 2015, Volume: 80, Issue:5

    Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Carboxylic Ester Hydrolases; Cross-Over Studies; Enalapril; Enalaprilat; Female; Genotype; Healthy Volunteers; Heart Rate; Humans; Male; Polymorphism, Single Nucleotide; Quinapril; Tetrahydroisoquinolines; Young Adult

2015

Other Studies

7 other study(ies) available for quinaprilat and enalapril

ArticleYear
Molecular and crystal structures of MDL27,467A hydrochloride and quinapril hydrochloride, two ester derivatives of potent angiotensin converting enzyme inhibitors.
    Journal of medicinal chemistry, 1991, Volume: 34, Issue:2

    Topics: Angiotensin-Converting Enzyme Inhibitors; Benzazepines; Crystallography; Isoquinolines; Pyridones; Quinapril; Tetrahydroisoquinolines

1991
Synthesis and biological activity of modified peptide inhibitors of angiotensin-converting enzyme.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:9

    Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Chemical Phenomena; Chemistry; Dipeptides; Enalapril; Guinea Pigs; Hypertension, Renal; Indoles; Isoquinolines; Quinapril; Rats; Structure-Activity Relationship; Tetrahydroisoquinolines

1985
Synthesis of novel angiotensin converting enzyme inhibitor quinapril and related compounds. A divergence of structure-activity relationships for non-sulfhydryl and sulfhydryl types.
    Journal of medicinal chemistry, 1986, Volume: 29, Issue:10

    Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Isoquinolines; Male; Molecular Conformation; Quinapril; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Sulfhydryl Compounds; Tetrahydroisoquinolines

1986
Compared properties of trandolapril, enalapril, and their diacid metabolites.
    Journal of cardiovascular pharmacology, 1994, Volume: 23 Suppl 4

    Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Enalapril; Enalaprilat; Indoles; Isoquinolines; Male; Peptidyl-Dipeptidase A; Rats; Rats, Inbred SHR; Solubility; Tetrahydroisoquinolines

1994
Protective effect of quinaprilat, an active metabolite of quinapril, on Ca2+-overload induced by lysophosphatidylcholine in isolated rat cardiomyocytes.
    Japanese journal of pharmacology, 1999, Volume: 79, Issue:1

    Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin; Calcium; Cell Size; Creatine Kinase; Enalapril; Enalaprilat; Isoquinolines; Lysophosphatidylcholines; Male; Micelles; Myocardium; Propranolol; Quinapril; Rats; Rats, Sprague-Dawley; Tetrahydroisoquinolines; Vasodilator Agents

1999
Competitive inhibition of glycylsarcosine transport by enalapril in rabbit renal brush border membrane vesicles: interaction of ACE inhibitors with high-affinity H+/peptide symporter.
    Pharmaceutical research, 1999, Volume: 16, Issue:5

    Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Binding, Competitive; Captopril; Carrier Proteins; Cell Membrane; Dipeptides; Dose-Response Relationship, Drug; Enalapril; Fosinopril; Isoquinolines; Kidney; Kinetics; Lipid Metabolism; Lipids; Lisinopril; Male; Microvilli; Peptide Transporter 1; Quinapril; Rabbits; Ramipril; Symporters; Tetrahydroisoquinolines

1999
Stimulation of renin secretion by angiotensin II blockade is Gsalpha-dependent.
    Journal of the American Society of Nephrology : JASN, 2010, Volume: 21, Issue:6

    Topics: Adenylyl Cyclases; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzimidazoles; Biphenyl Compounds; Captopril; Catecholamines; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enalapril; Female; GTP-Binding Protein alpha Subunits, Gs; Juxtaglomerular Apparatus; Male; Mice; Mice, Knockout; Models, Animal; Nitric Oxide; Prostaglandins; Renin; Signal Transduction; Tetrahydroisoquinolines; Tetrazoles

2010