Compounds > quinaprilat
Page last updated: 2024-09-02

quinaprilat and carvedilol

quinaprilat has been researched along with carvedilol in 4 studies

Compound Research Comparison

Studies
(quinaprilat)		Trials
(quinaprilat)		Recent Studies (post-2010)
(quinaprilat)		Studies
(carvedilol)		Trials
(carvedilol)		Recent Studies (post-2010) (carvedilol)
922342,9336801,052

Protein Interaction Comparison

ProteinTaxonomyquinaprilat (IC50)carvedilol (IC50)
Solute carrier family 22 member 2Homo sapiens (human)7.5
Solute carrier family 22 member 1 Homo sapiens (human)3.4
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.115
Potassium channel subfamily K member 2Homo sapiens (human)1.6
Beta-2 adrenergic receptorHomo sapiens (human)0.0002
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)0.538
ATP-dependent translocase ABCB1Homo sapiens (human)5.7333
Beta-1 adrenergic receptorHomo sapiens (human)0.0002
Alpha-2A adrenergic receptorHomo sapiens (human)0.106
Angiotensin-converting enzymeOryctolagus cuniculus (rabbit)4.1193
Beta-3 adrenergic receptorHomo sapiens (human)0.0042
D(2) dopamine receptorHomo sapiens (human)0.146
Alpha-2B adrenergic receptorHomo sapiens (human)0.094
Alpha-2C adrenergic receptorHomo sapiens (human)0.09
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)0.0058
D(1A) dopamine receptorHomo sapiens (human)1.498
Sodium-dependent noradrenaline transporter Homo sapiens (human)0.538
Alpha-1D adrenergic receptorHomo sapiens (human)0.0018
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.41
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.115
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)0.0058
Sodium-dependent serotonin transporterHomo sapiens (human)0.221
D(3) dopamine receptorHomo sapiens (human)0.577
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.023
5-hydroxytryptamine receptor 6Homo sapiens (human)1.519
Potassium channel subfamily K member 10Homo sapiens (human)7.6
Sodium-dependent dopamine transporter Homo sapiens (human)0.845
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)2.2346
Cytochrome P450 1B1Homo sapiens (human)1.1
Nuclear receptor subfamily 3 group C member 3 Bos taurus (cattle)4.1193

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (75.00)29.6817
2010's1 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lombardo, F; Obach, RS; Waters, NJ1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Albu, F; Cristea, E; David, V; Medvedovici, A; Sora, I; Udrescu, S1

Trials

1 trial(s) available for quinaprilat and carvedilol

ArticleYear
LC-MS/MS assay of quinapril and its metabolite quinaprilat for drug bioequivalence evaluation: prospective, concurrential and retrospective method validation.
    Bioanalysis, 2009, Volume: 1, Issue:1

    Topics: Adult; Biological Assay; Calibration; Carbazoles; Carvedilol; Chromatography, Liquid; Cross-Over Studies; Drug Evaluation; Female; Humans; Male; Propanolamines; Quinapril; Reference Standards; Reproducibility of Results; Solid Phase Extraction; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Tetrahydroisoquinolines; Therapeutic Equivalency; Young Adult

2009

Other Studies

3 other study(ies) available for quinaprilat and carvedilol

ArticleYear
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010