Page last updated: 2024-09-02

quinaprilat and captopril

quinaprilat has been researched along with captopril in 15 studies

Compound Research Comparison

Studies
(quinaprilat)
Trials
(quinaprilat)
Recent Studies (post-2010)
(quinaprilat)
Studies
(captopril)
Trials
(captopril)
Recent Studies (post-2010) (captopril)
9223410,3201,514890

Protein Interaction Comparison

ProteinTaxonomyquinaprilat (IC50)captopril (IC50)
Leukotriene A-4 hydrolaseHomo sapiens (human)3.6
Angiotensin-converting enzyme Homo sapiens (human)0.084
Angiotensin-converting enzymeOryctolagus cuniculus (rabbit)0.0173
Succinyl-diaminopimelate desuccinylaseHaemophilus influenzae Rd KW203.3
Angiotensin-converting enzymeRattus norvegicus (Norway rat)0.1004
Beta-lactamase Pseudomonas aeruginosa5
Angiotensin-converting enzyme 2 Homo sapiens (human)0.011
Beta-lactamase class B VIM-2 Pseudomonas aeruginosa3.5

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19902 (13.33)18.7374
1990's6 (40.00)18.2507
2000's5 (33.33)29.6817
2010's2 (13.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cohen, D; Essenburg, AD; Kaplan, HR; Roark, WH; Tinney, FJ1
Blankley, CJ; Cohen, DM; Essenburg, AD; Fleming, RW; Hinkley, JM; Hoefle, ML; Holmes, A; Klutchko, S; Nordin, I; Werner, AE1
Lombardo, F; Obach, RS; Waters, NJ1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Dargie, HJ; Dominiczak, M; Godfrey, EG; Hamilton, CA; McMurray, J; Reid, JL; Stewart, J1
Benigno, M; Bernocchi, P; Boraso, A; Cargnoni, A; Ferrari, R; Ghirardelli, N; Pedersini, P; Scotti, C1
Bumpus, FM; Husain, A; Kinoshita, A; Urata, H1
Anning, PB; Grocott-Mason, RM; Lewis, MJ1
Akarawut, W; Lin, CJ; Smith, DE1
Fabre, JE; Isner, JM; Magner, M; Rivard, A; Silver, M1
Danser, AH; de Vries, R; Saxena, PR; Tom, B1
Batenburg, WW; Danser, AH; de Bruijn, RJ; de Vries, R; Dive, V; Georgiadis, D; Tom, B; van Esch, JH; van Gool, JM; Yiotakis, A1
Briggs, JP; Chen, L; Faulhaber-Walter, R; Huang, Y; Kim, SM; Mizel, D; Oppermann, M; Schnermann, J1
Briggs, JP; Chen, L; Chen, M; Eisner, C; Gomez, RA; Huang, Y; Kim, SM; Li, L; Mizel, D; Oppermann, M; Schnermann, J; Sequeira Lopez, ML; Weinstein, LS1

Other Studies

15 other study(ies) available for quinaprilat and captopril

ArticleYear
Synthesis and biological activity of modified peptide inhibitors of angiotensin-converting enzyme.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:9

    Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Chemical Phenomena; Chemistry; Dipeptides; Enalapril; Guinea Pigs; Hypertension, Renal; Indoles; Isoquinolines; Quinapril; Rats; Structure-Activity Relationship; Tetrahydroisoquinolines

1985
Synthesis of novel angiotensin converting enzyme inhibitor quinapril and related compounds. A divergence of structure-activity relationships for non-sulfhydryl and sulfhydryl types.
    Journal of medicinal chemistry, 1986, Volume: 29, Issue:10

    Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Isoquinolines; Male; Molecular Conformation; Quinapril; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Sulfhydryl Compounds; Tetrahydroisoquinolines

1986
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Effects of ACE inhibitors on oxidation of human low density lipoprotein.
    British journal of clinical pharmacology, 1994, Volume: 37, Issue:1

    Topics: Acetylcysteine; Analysis of Variance; Angiotensin-Converting Enzyme Inhibitors; Captopril; Copper; Female; Humans; Isoquinolines; Lipoproteins, LDL; Oxidation-Reduction; Tetrahydroisoquinolines

1994
Effect of angiotensin converting enzyme inhibition with quinaprilat on the ischaemic and reperfused myocardium.
    Journal of molecular and cellular cardiology, 1994, Volume: 26, Issue:1

    Topics: Adenosine Triphosphate; Angiotensin-Converting Enzyme Inhibitors; Animals; Calcium; Captopril; Creatine Kinase; Heart; Homeostasis; Isoquinolines; Lactates; Lactic Acid; Male; Myocardial Reperfusion Injury; Norepinephrine; Oxidation-Reduction; Phosphocreatine; Rabbits; Tetrahydroisoquinolines

1994
Measurement of angiotensin I converting enzyme inhibition in the heart.
    Circulation research, 1993, Volume: 73, Issue:1

    Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Captopril; Cricetinae; Dipeptides; Enalaprilat; Humans; Isoquinolines; Lisinopril; Male; Mesocricetus; Papillary Muscles; Tetrahydroisoquinolines

1993
Effects of sulphydryl- and non-sulphydryl-containing ACE inhibitors on left ventricular relaxation in the isolated guinea pig heart.
    Endothelium : journal of endothelial cell research, 1997, Volume: 5, Issue:4

    Topics: Acetylcysteine; Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin; Bradykinin Receptor Antagonists; Captopril; Diastole; Female; Free Radical Scavengers; Guinea Pigs; Heart Ventricles; Hemoglobins; Isoquinolines; Lisinopril; Male; Muscle Relaxation; Nitric Oxide; Receptor, Bradykinin B2; Simethicone; Stroke Volume; Sulfhydryl Compounds; Superoxide Dismutase; Systole; Tetrahydroisoquinolines; Ventricular Dysfunction, Left

1997
Competitive inhibition of glycylsarcosine transport by enalapril in rabbit renal brush border membrane vesicles: interaction of ACE inhibitors with high-affinity H+/peptide symporter.
    Pharmaceutical research, 1999, Volume: 16, Issue:5

    Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Binding, Competitive; Captopril; Carrier Proteins; Cell Membrane; Dipeptides; Dose-Response Relationship, Drug; Enalapril; Fosinopril; Isoquinolines; Kidney; Kinetics; Lipid Metabolism; Lipids; Lisinopril; Male; Microvilli; Peptide Transporter 1; Quinapril; Rabbits; Ramipril; Symporters; Tetrahydroisoquinolines

1999
Tissue inhibition of angiotensin-converting enzyme activity stimulates angiogenesis in vivo.
    Circulation, 1999, Jun-15, Volume: 99, Issue:23

    Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Captopril; Carotid Artery, Common; Endothelial Growth Factors; Femoral Artery; Hemodynamics; Hindlimb; Humans; Isoquinolines; Lymphokines; Muscle, Smooth, Vascular; Neovascularization, Physiologic; Peptidyl-Dipeptidase A; Rabbits; Recombinant Proteins; Regional Blood Flow; Tetrahydroisoquinolines; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Vascular Resistance; Vasodilation

1999
Bradykinin potentiation by angiotensin-(1-7) and ACE inhibitors correlates with ACE C- and N-domain blockade.
    Hypertension (Dallas, Tex. : 1979), 2001, Volume: 38, Issue:1

    Topics: Adolescent; Adult; Angiotensin I; Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin; Captopril; Coronary Vessels; Drug Synergism; Female; Humans; In Vitro Techniques; Isoquinolines; Male; Peptide Fragments; Peptidyl-Dipeptidase A; Protein Structure, Tertiary; Receptor, Bradykinin B2; Receptors, Bradykinin; Swine; Tetrahydroisoquinolines; Vasodilation

2001
Selective angiotensin-converting enzyme C-domain inhibition is sufficient to prevent angiotensin I-induced vasoconstriction.
    Hypertension (Dallas, Tex. : 1979), 2005, Volume: 45, Issue:1

    Topics: Adolescent; Adult; Angiotensin I; Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin; Captopril; Coronary Vessels; Dose-Response Relationship, Drug; Female; Femoral Artery; Humans; Male; Microcirculation; Middle Aged; Oligopeptides; Organ Specificity; Peptidyl-Dipeptidase A; Phosphinic Acids; Protein Structure, Tertiary; Solubility; Structure-Activity Relationship; Sus scrofa; Tetrahydroisoquinolines; Vasoconstriction

2005
Regulation of renin secretion and expression in mice deficient in beta1- and beta2-adrenergic receptors.
    Hypertension (Dallas, Tex. : 1979), 2007, Volume: 50, Issue:1

    Topics: Aldosterone; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzimidazoles; Biphenyl Compounds; Captopril; Dose-Response Relationship, Drug; Furosemide; Mice; Mice, Knockout; Osmolar Concentration; Receptors, Adrenergic, beta-1; Receptors, Adrenergic, beta-2; Renin; RNA, Messenger; Sodium Chloride, Dietary; Tetrahydroisoquinolines; Tetrazoles

2007
Stimulation of renin secretion by angiotensin II blockade is Gsalpha-dependent.
    Journal of the American Society of Nephrology : JASN, 2010, Volume: 21, Issue:6

    Topics: Adenylyl Cyclases; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzimidazoles; Biphenyl Compounds; Captopril; Catecholamines; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enalapril; Female; GTP-Binding Protein alpha Subunits, Gs; Juxtaglomerular Apparatus; Male; Mice; Mice, Knockout; Models, Animal; Nitric Oxide; Prostaglandins; Renin; Signal Transduction; Tetrahydroisoquinolines; Tetrazoles

2010