quinacrine has been researched along with arachidonic acid in 237 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 95 (40.08) | 18.7374 |
| 1990's | 113 (47.68) | 18.2507 |
| 2000's | 24 (10.13) | 29.6817 |
| 2010's | 5 (2.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fijorek, K; Glinka, A; Mendyk, A; Polak, S; Wiśniowska, B | 1 |
| Botti, D; Cifone, MG; Del Grosso, E; Frati, L; Gazzaniga, PP; Pulcinelli, FM; Riondino, S; Santoni, A; Testi, R | 1 |
| Goracci, G; Gresele, P; Nenci, GG; Porcellati, S; Quero, E; Stasi, M | 1 |
| Fujita, A; Hata, F; Takeuchi, T; Yagasaki, O | 1 |
| Jordan, P; Kaszkin, M; Kinzel, V; Schiess, K; Seidler, L | 1 |
| Apgar, JR; Mescher, MF; O'Rourke, AM | 1 |
| Kozawa, O; Miwa, M; Oiso, Y; Ozaki, N; Takahashi, Y; Tokuda, H | 1 |
| Cohen, HT; Katz, AI; Satoh, T | 1 |
| Morii, M; Okada, Y; Sakai, H; Takeguchi, N | 1 |
| Bonnet, P; Bourdeau, A; Herviaux, P; Lieberherr, M; Sachs, C; Souberbielle, JC | 1 |
| Borrell, J; Cambronero, JC; Guaza, C; Rivas, FJ | 1 |
| Farkas, T; Kuehn, H; Nemecz, G; Wallukat, G; Wollenberger, A | 1 |
| Kojo, T | 1 |
| Abayasekara, DR; Chaudry, L; Choi, MS; Cooke, BA; Dirami, G; Phipp, L | 1 |
| Capito, K; Gembal, M; Hedeskov, CJ; Malik, T; Thams, P | 1 |
| Cordier, J; Delumeau, JC; Glowinski, J; Marin, P; Premont, J; Tence, M | 1 |
| Okuda, M; Takeuchi, T; Yagasaki, O | 1 |
| Bowen, DJ; Yau, WM; Youther, ML | 1 |
| Collins, JL; Kao, MS; Mutch, DG; Powell, CB | 1 |
| Brown, EJ; Lennartz, MR | 1 |
| Dettori, C; Magistretti, J; Meldolesi, J | 1 |
| Barja-Fidalgo, C; Carlini, CR; Guimaraes, JA | 1 |
| Bennett, CF; Chilton, FH; Sung, CM; Winkler, JD | 1 |
| Abdalla, S; Afifi, F; al-Khalil, S | 1 |
| Fujii, T; Hashizume, T; Kawamoto, A; Sato, T; Tamura, A; Yamaguchi, H | 1 |
| Bose, D; Elliott, DA; Gu, M; Ong, BY | 1 |
| Diener, M; Rummel, W | 2 |
| Nakashima, S; Nozawa, Y | 1 |
| Madamba, S; Schweitzer, P; Siggins, GR | 1 |
| Aguila, MC; McCann, SM; Milenkovic, L; Snyder, GD | 1 |
| Fitzgerald, TP; Granger, GA; Knauer, MF; Longmuir, KJ; Yamamoto, RS | 1 |
| Ralph, RK; Wojcik, S | 1 |
| Myatt, L; Sander, J | 1 |
| Mahadevappa, VG; Sicilia, F | 1 |
| De Groot, MJ; Engels, W; Lemmens, PJ; Reneman, RS; Van Bilsen, M; Van der Vusse, GJ; Willemsen, PH | 1 |
| Imamura, K; Kufe, DW; Mohri, M; Robbins, G; Rodriguez, C; Sherman, ML; Spriggs, DR | 1 |
| Burgoyne, RD; Morgan, A | 1 |
| Hunt, A; Patel, AJ; Sanfeliu, C | 1 |
| Heller, PH; Levine, JD; Taiwo, YO | 1 |
| Samochocki, M; Strosznajder, J | 1 |
| AbuBakar, S; Albrecht, T; Boldogh, I | 1 |
| Akino, T; Hasegawa-Sasaki, H; Tanaka, S; Watanabe, H | 1 |
| Costa, E; Lazarewicz, JW; Wroblewski, JT | 1 |
| Ausiello, DA; Birnbaumer, L; Cantiello, HF; Codina, J; Patenaude, CR | 1 |
| Fuchimoto, S; Orita, K; Shiiki, S | 1 |
| de Graeff, PA; de Langen, CD; Scholtens, E; van Gilst, WH; van Wijngaarden, J; Wesseling, H | 1 |
| Kahane, VL; Setton, CP; Speziale, EH; Sterin-Speziale, NB | 1 |
| Franchi, AM; Gimeno, AL; Gimeno, MA | 1 |
| Gurtner, GH; McShane, AJ; Shayevitz, JR; Traystman, RJ | 1 |
| Das, DK; Jones, RM; Otani, H; Prasad, MR | 1 |
| Chihara, M; Hagino, Y; Nomura, H; Nomura, T; Nomura, Y; Tachibana, M | 1 |
| Evans, J; Shaw, KP; Vernon, LP; Wang, YD | 1 |
| Buja, LM; Chien, KR; Hagler, HK; Jones, RL; Miller, JC; Willerson, JT | 1 |
| McMorris, FA; Shin, ML; Shirazi, Y | 1 |
| Kendall, DA; Robinson, JP | 1 |
| Magistretti, PJ; Martin, JL | 1 |
| Kahane, VL; Setton, CP; Speziale, EH; Sterin-Speziale, N | 1 |
| Chappell, JB; Henderson, LM; Jones, OT | 1 |
| Canonico, PL; Cronin, MJ; MacLeod, RM; Scapagnini, U; Sortino, MA; Speciale, C | 1 |
| Harbison, RG; Ignarro, LJ; Kadowitz, PJ; Wood, KS | 1 |
| Cannizzaro, S; Davì, G; Giubilato, A; Strano, A | 1 |
| Ho, AK; Klein, DC | 1 |
| Arita, H; Hanasaki, K; Nakano, T | 1 |
| Canonico, PL; Judd, AM; Koike, K; MacLeod, RM; Valdenegro, CA | 1 |
| Brinkman, HJ; de Groot, PG; Gonsalves, MD; Van Mourik, JA | 1 |
| Brazy, PC; Klotman, PE; Trellis, DR | 1 |
| Alcaraz, MJ | 1 |
| Knepel, W; Meyen, G | 1 |
| Maridonneau-Parini, I; Tauber, AI | 1 |
| Bell, AL; Betts, WH; Cleland, LG; French, JK; Hurst, NP; Nuki, G; O'Donnell, ML | 1 |
| Aoyagi, T; Halprin, KM; Kato, N; Suya, H; Taylor, JR | 1 |
| Evans, PM; Lanham, DF | 1 |
| Maridonneau-Parini, I; Tauber, AI; Tringale, SM | 1 |
| Brotherton, AF | 1 |
| Bateman, PE; Meade, CJ; Turner, GA | 1 |
| Cooper, CL; Malik, KU | 1 |
| Danon, A; Davis, BB; Thomasson, DL; Zenser, TV | 1 |
| Azuma, H; Ishikawa, M; Sekizaki, S | 1 |
| Breyer, RH; Das, DK; Engelman, RM; Otani, H; Rousou, JA | 1 |
| Dandona, P; Jeremy, J; Morrow, C; Murphy, S; Pearce, B | 2 |
| Ofenstein, JP; Rillema, JA | 1 |
| Hauser, G; Jadali, F; Kiesel, L; Przylipiak, A; Rabe, T; Runnebaum, B | 1 |
| DeGeorge, JJ; Lapetina, EG; McCarthy, KD; Morell, P; Ousley, AH | 1 |
| Delvos, U; Janssen, B; Müller-Berghaus, G | 1 |
| Rubanyi, GM; Vanhoutte, PM | 1 |
| Hirafuji, M; Nave, JF | 1 |
| Miura, K; Nozawa, Y; Okano, Y; Yamada, K | 1 |
| Asami, A; Asami, T; Hori, T; Koga, H; Nakashima, T; Shibata, M; Yamasaki, M | 1 |
| Takeuchi, T; Yagasaki, O | 1 |
| Imamura, S; Miyachi, Y; Yoshioka, A | 1 |
| Metz, SA | 1 |
| Nakagawa, Y; Waku, K | 1 |
| Hashimura, T; Kanamaru, H; Yoshida, O | 1 |
| Dorman, RV; Schwartz, MA; Terrian, DM | 1 |
| Cassina, G; Livio, M; Macconi, D; Morelli, C; Morzenti, G; Remuzzi, G | 1 |
| Sugiura, T; Waku, K | 1 |
| Odessey, R | 1 |
| Kojima, I; Kojima, K; Rasmussen, H | 1 |
| Canonico, PL; Scapagnini, U; Sortino, MA; Speciale, C | 1 |
| Balla, T; Enyedi, P; Hunyady, L; Spät, A | 1 |
| Gerrard, JM; McCrea, JM; Robinson, P | 1 |
| Fujimoto, Y; Fujita, T; Kagen, C; Ueno, T; Uno, H | 1 |
| Fujimoto, Y; Fujita, T; Tanioka, H; Toibana, E; Yamamoto, T | 1 |
| Andersson, RG; Norrby, K | 1 |
| Axelrod, J; Crews, FT; Hirata, F; McGivney, A; Morita, Y; Siraganian, RP | 1 |
| Alonso, F; Alvarez Chiva, V; García Gil, M; Mato, JM; Sánchez Crespo, M | 1 |
| Sinha, BK | 1 |
| Furchgott, RF | 1 |
| Billah, MM; Cuatrecasas, P; Lapetina, EG | 1 |
| Parker, CW | 1 |
| Piper, PJ; Samhoun, MN | 1 |
| Abdel-Latif, AA; Akhtar, RA; Smith, JP | 1 |
| Lasslo, A | 1 |
| Homma, Y; Nagai, Y; Takenawa, T | 2 |
| Bult, H; Claeys, M; Herman, AG; Rampart, M; Van Hove, C | 1 |
| Kagawa, S; Matsuoka, A; Murakoso, K; Shimizu, S; Tanaka, N | 1 |
| Peach, MJ; Singer, HA | 1 |
| Canonico, PL; MacLeod, RM; Schettini, G; Valdenegro, CA | 1 |
| Dahl, ML; Puustinen, T; Uotila, P | 1 |
| Grandison, L | 1 |
| Raz, A | 1 |
| Azuri, R; Erman, A; Raz, A | 1 |
| Canonico, PL; Judd, AM; MacLeod, RM; Valdenegro, CA | 1 |
| Puustinen, T | 1 |
| Miller, RJ; Vicentini, LM; Villereal, ML | 1 |
| Folkert, VW; Schlondorff, D; Yunis, M | 1 |
| Brammer, JP; Maguire, MH | 1 |
| Carine, K; Hudig, D | 1 |
| Liggins, GC; Neale, G; Skinner, SJ; Wilson, T | 1 |
| Kennedy, I; Langley, M; Whelan, CJ | 1 |
| Feinstein, MB; Opas, EE; Walenga, RW | 1 |
| Burch, JW; Dise, CA; Goodman, DB | 1 |
| Billah, MM; Lapetina, EG | 1 |
| Mitchell, HW | 1 |
| Ishii, M; Kato, R; Nakadate, T; Yamamoto, S | 1 |
| Hofmann, SL; Majerus, PW; Prescott, SM | 1 |
| Abdel-Latif, AA; Smith, JP | 1 |
| Enmi, K; Fujimoto, Y; Fujita, T; Shimizu, K | 1 |
| Fujimoto, R; Hata, F; Kubo, T; Nagao, T; Nishio, H; Takeuchi, T | 1 |
| Klöcking, R; Müller, WE; Nishio, O; Perovic, S; Ushijima, H | 1 |
| Béréziat, G; Lemnaouar, M; Levistre, R; Masliah, J; Rybkine, T | 1 |
| Bockaert, J; Culcasi, M; Lafon-Cazal, M; Pietri, S | 1 |
| Gustafsson, JA; Hamberg, M; Mode, A; Tollet, P | 1 |
| Kurahashi, K; Nishimura, Y; Suzuki, A; Usui, H | 1 |
| Käfer, A; Krug, HF | 1 |
| Martin, D; Nadler, JV; Peterson, CL; Thompson, MA | 1 |
| Legere, RH; Majerus, BJ; Petrali, JP; Ray, R | 1 |
| Belton, CM; Fatherazi, S; Izutsu, KT; Wellner, RB | 1 |
| Bauersachs, J; Busse, R; Hecker, M | 1 |
| Villarroel, A | 1 |
| Lazarewicz, JW; Salińska, E | 1 |
| Johnson, MS; Mitchell, R; Thomson, FJ; Wolbers, B | 1 |
| Ciaranello, RD; Harrington, MA; Shaw, K; Zhong, P | 1 |
| D'Amore, PA; Dethlefsen, SM; Shepro, D | 1 |
| Jung, H; Remé, C | 1 |
| Mitchell, R; Thomson, FJ | 1 |
| Kanaho, Y; Matsunaga, T; Nozawa, Y; Suzuki, N | 1 |
| Dana, R; Levy, R; Malech, HL | 1 |
| Brown, BL; Dobson, PR; Virdee, K | 1 |
| Alexander, RW; Griendling, KK; Lassègue, B; Rao, GN | 1 |
| Burch, RA; Kulp, GV; Leff, AR; Neeley, SP; Spaethe, SM; Strek, ME; White, SR | 1 |
| Butcher, RD; Lints, T; Ralph, R; Schofield, PC; Wilson, T; Wojcik, SJ | 1 |
| Beraud, M; Bessieres, MH; Frisach, MF; M'Rini, C; Pipy, B; Seguela, JP; Thardin, JF; Vandaele, J | 1 |
| Alexander, RW; Berk, BC; Griendling, KK; Lasségue, B; Rao, GN | 1 |
| Bjøro, T; Englund, K; Haug, E; Torjesen, PA | 1 |
| Arnould, T; Dieu, M; Knott, I; Michiels, C; Remacle, J | 1 |
| Berman, JD; Brendle, J; Middleton, W; Ray, P | 1 |
| Linch, DC; Roberts, PJ; Williams, SL | 1 |
| Adachi, T; Nakamura, T; Nakashima, S; Nozawa, Y; Saji, S | 1 |
| Chalimoniuk, M; Samochocki, M; Strosznajder, J | 1 |
| Donowitz, M; Flick, J; Levine, SA; Madara, JL; Sharp, GW; Tai, YH | 1 |
| Ganey, PE; Peters-Golden, M; Schiamberg, E; Tithof, PK | 1 |
| Hata, F; Nishio, H; Takeuchi, T; Yagasaki, O | 1 |
| Etter, JD; Naegeli, P; Shaw, S; Weidmann, P | 1 |
| Arita, Y; Hou, W; Morisset, J | 2 |
| Kinoshita, M; Tamaki, H | 1 |
| Castell, A; González, L; Nekrassov, V; Sitges, M | 1 |
| Fyfe, GK; Kemp, PJ; Olver, RE | 1 |
| Csaba, G; Kovács, P | 1 |
| Bashan, N; Kozlovsky, N; Shohami, E | 1 |
| Matzel, LD; Muzzio, IA; Talk, AC | 1 |
| Van de Voorde, J; Vanheel, B | 1 |
| Kozawa, O; Oiso, Y; Saito, H; Shinoda, J; Suzuki, A; Watanabe-Tomita, Y | 1 |
| Mau, SE; Vilhardt, H | 1 |
| Adeagbo, AS | 1 |
| Fujimoto, R; Hata, F; Ishii, T; Nishio, H; Saitoh, N; Takeuchi, T | 1 |
| Conte, D; Fillo, S; Isidori, A; Romanelli, F | 1 |
| Capasso, A; Sorrentino, L | 1 |
| Strosznajder, J | 1 |
| Camarasa, J; Camins, A; Escubedo, E; Gabriel, C; Pallàs, M; Sureda, FX | 1 |
| Creer, MH; McHowat, J | 1 |
| Alexander, LD; Chang, CH; Cui, XL; Douglas, JG; Jiao, H; Lapetina, EG; Torti, M | 1 |
| Paolillo, M; Schinelli, S; Zanassi, P | 1 |
| Burden, RP; Daniels, I; Fletcher, J; Haynes, AP; Keany, CI; Lindsay, MA | 1 |
| Dohi, S; Kozawa, O; Matsuno, H; Niwa, M; Tanabe, K; Uematsu, T | 1 |
| Blanchet, F; Gauchy, C; Glowinski, J; Kemel, ML; Perez, S | 1 |
| Artaud, F; Chéramy, A; Glowinski, J; Godeheu, G; L'hirondel, M | 1 |
| Farrell, KR; Hester, RL; Ligon, AL; Nuttle, LC | 1 |
| Jacobson, BS; Whitfield, RA | 1 |
| Choi, HS; Han, HJ; Koh, HJ; Nah, SY; Park, SH; Shin, DH | 1 |
| Stocco, DM; Walsh, LP; Wang, X | 1 |
| Honeyman, TW; Kennington, L; Kohjimoto, Y; Scheid, CR | 1 |
| Giembycz, MA; Hellewell, PG; Lindsay, MA; Teixeira, MM | 1 |
| Friebe, WG; Hinder, M; Kaiser, B; Scheuer, W; Schramm, S; Tibes, U | 1 |
| Bader, BW; Bankhurst, AD; Doshi, RN; Whalen, MM | 1 |
| Choi, HJ; Han, HJ; Park, SH | 1 |
| Hirata, M; Murakami, Y; Okada, S; Wang, M; Yokotani, K | 1 |
| Advenier, C; Ausina, P; Candenas, ML; Marthan, R; Pinto, FM; Savineau, JP; Strippoli, G; Trujillo, MM | 1 |
| Gravel, K; Honeyman, TW; Jonassen, J; Kennington, L; Kohjimoto, Y; Scheid, CR | 1 |
| Figliola, R; Lioni, S; Mangiantini, MT; Marino, M; Mele, R; Spagnuolo, S | 1 |
| Cantoni, O; Fiorani, M; Guidarelli, A | 1 |
| Beyreuther, K; Cappai, R; Collins, SJ; Jobling, MF; Maher, F; Masters, CL; Needham, BE; Stewart, LR; Thyer, J; White, AR | 1 |
| Kalendo, GS; Karu, TI; Pyatibrat, LV | 1 |
| Llanos, MN; Moraga, PF; Ronco, AM | 1 |
| Cussac, D; Denis, C; Paris, H; Schaak, S | 1 |
| Cantoni, O; Guidarelli, A | 1 |
| Han, HJ; Kang, SK; Lee, HJ; Lee, JH; Mar, WC; Park, KM; Park, SH; Yoon, BC | 1 |
| Barrachina, MD; Calatayud, S; Esplugues, JV; Felipo, V; García-Zaragozá, E; Hernández, C; Quintana, E | 1 |
| Geli, J; Kozma, N; Par, G; Szekeres-Bartho, J; Varga, P | 1 |
| Caro, AA; Cederbaum, AI | 1 |
| Davies, JE; Jennings, SC; Ng, LL; Pettit, AI; Quinn, PA; Wong, RK | 1 |
| Arai, J; Okada, S; Shimizu, T; Wakiguchi, H; Yamaguchi, N; Yokotani, K | 1 |
| Flordellis, C; Karkoulias, G; Lymperopoulos, A; Mastrogianni, O; Paris, H | 1 |
| Campello-Costa, P; Fosse-Júnior, AM; Oliveira-Silva, P; Serfaty, CA | 1 |
| Lu, L; Okada, S; Sasaki, T; Shimizu, T; Yamaguchi, N; Yokotani, K | 1 |
| Han, HJ; Heo, JS; Lee, MY; Na, SI | 1 |
| Rudzevich, AJ; Shapovalova, EM | 1 |
| Fan, M; Gao, JT; Ge, XM; Liu, SH; Wang, H; Wu, HT; Wu, Y; Xing, C; Yan, YE; Zhao, YQ | 1 |
| Bugge, E; Tveita, T; Ytrehus, K | 1 |
| Ajmat, MT; Bonilla, F; Bühler, MI; Hermosilla, PC; Zelarayán, L | 1 |
| Diener, M; Rehn, M | 1 |
| Mori, T; Shibasaki, M; Shimizu, N; Suzuki, T | 1 |
| Bühler, MI; Ortiz, ME; Zelarayán, LI | 1 |
3 review(s) available for quinacrine and arachidonic acid
| Article | Year |
|---|---|
[Platelet function inhibitors in peripheral arteriopathies].
Topics: Adrenal Cortex Hormones; Adrenergic alpha-Antagonists; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Arteriosclerosis Obliterans; Aspirin; Blood Platelets; Calcium Channel Blockers; Clinical Trials as Topic; Cyclic AMP; Dipyridamole; Extremities; Heparin; Humans; Imidazoles; Prostaglandins; Prostanoic Acids; Pyrazoles; Pyrazolones; Quinacrine; Thiophenes; Thromboembolism; Thrombosis; Ticlopidine; Vascular Diseases | 1986 |
The role of endothelium in the responses of vascular smooth muscle to drugs.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Acetophenones; Acetylcholine; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Bradykinin; Calcimycin; Catechols; Endothelium; Histamine; Hydroquinones; Hypoxia; Masoprocol; Methylene Blue; Muscle Relaxation; Muscle, Smooth, Vascular; Prostaglandins; Quinacrine; Serotonin; Substance P; Thrombin | 1984 |
Blood platelet function, medicinal agents, and other chemical entities.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Amines; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Blood Vessels; Calcium; Cell Membrane; Chlorpromazine; Dipyridamole; Humans; Papaverine; Phospholipids; Platelet Aggregation; Propranolol; Quinacrine; Structure-Activity Relationship; Tretoquinol | 1984 |
1 trial(s) available for quinacrine and arachidonic acid
| Article | Year |
|---|---|
[Platelet function inhibitors in peripheral arteriopathies].
Topics: Adrenal Cortex Hormones; Adrenergic alpha-Antagonists; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Arteriosclerosis Obliterans; Aspirin; Blood Platelets; Calcium Channel Blockers; Clinical Trials as Topic; Cyclic AMP; Dipyridamole; Extremities; Heparin; Humans; Imidazoles; Prostaglandins; Prostanoic Acids; Pyrazoles; Pyrazolones; Quinacrine; Thiophenes; Thromboembolism; Thrombosis; Ticlopidine; Vascular Diseases | 1986 |
234 other study(ies) available for quinacrine and arachidonic acid
| Article | Year |
|---|---|
Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment.
Topics: Artificial Intelligence; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Computational Biology; Computer Simulation; Drugs, Investigational; Ether-A-Go-Go Potassium Channels; Expert Systems; Heart Rate; Humans; Models, Biological; Myocytes, Cardiac; NAV1.5 Voltage-Gated Sodium Channel; Potassium Channel Blockers; Quantitative Structure-Activity Relationship; Risk Assessment; Shaker Superfamily of Potassium Channels; Torsades de Pointes; Voltage-Gated Sodium Channel Blockers | 2012 |
Preferential involvement of a phospholipase A2-dependent pathway in CD69-mediated platelet activation.
Topics: Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Arachidonic Acid; Diglycerides; Humans; In Vitro Techniques; Inositol Phosphates; Lectins, C-Type; Pentanoic Acids; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoinositide Phospholipase C; Phospholipases A; Phospholipases A2; Phosphoric Diester Hydrolases; Platelet Activation; Pyridines; Quinacrine; Receptors, Prostaglandin; Receptors, Thromboxane; Thromboxane-A Synthase | 1992 |
Activation of phospholipase A2 and beta-thromboglobulin release in human platelets: comparative effects of thrombin and fluoroaluminate stimulation.
Topics: Aluminum; Arachidonic Acid; beta-Thromboglobulin; Blood Platelets; Cyclic GMP; Enzyme Activation; Fluorine; GTP-Binding Proteins; Humans; Neomycin; Nitroprusside; Phospholipases A; Phospholipases A2; Quinacrine; Thrombin; Type C Phospholipases | 1992 |
Role of PGE2 in neurotransmission from pre- to post-ganglionic hypogastric nerves of guinea pigs.
Topics: Animals; Arachidonic Acid; Dinoprostone; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Indomethacin; Male; Quinacrine; Synaptic Transmission; Vas Deferens | 1992 |
Mobilization of diacylglycerol in intact HeLa cells by exogenous phospholipase C from Cl. perfringens is accompanied by release of fatty acids including arachidonic acid.
Topics: Arachidonic Acid; Chromatography, Thin Layer; Clostridium perfringens; Diglycerides; Egtazic Acid; Enzyme Activation; Fatty Acids; Fluocinolone Acetonide; HeLa Cells; Humans; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoinositide Phospholipase C; Phospholipases A; Phospholipases A2; Phosphoric Diester Hydrolases; Quinacrine; Type C Phospholipases | 1992 |
IgE receptor-mediated arachidonic acid release by rat basophilic leukemia (RBL-2H3) cells: possible role in activating degranulation.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Antigens; Arachidonic Acid; Cell Degranulation; Dose-Response Relationship, Immunologic; Fatty Acids; Inositol Phosphates; Ionomycin; Leukemia, Basophilic, Acute; Phosphatidylinositol Phosphates; Phosphatidylinositols; Phospholipases A; Phospholipases A2; Quercetin; Quinacrine; Rats; Receptors, IgE; Serotonin; Signal Transduction; Time Factors | 1992 |
Mechanism of prostaglandin E2-induced arachidonic acid release in osteoblast-like cells: independence from phosphoinositide hydrolysis.
Topics: Arachidonic Acid; Cells, Cultured; Dinoprostone; Dose-Response Relationship, Drug; Hydrolysis; Inositol 1,4,5-Trisphosphate; Osteoblasts; Pertussis Toxin; Phosphatidylinositols; Quinacrine; Sodium Fluoride; Tritium; Virulence Factors, Bordetella | 1992 |
Intracellular signaling in the regulation of renal Na-K-ATPase. I. Role of cyclic AMP and phospholipase A2.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Arachidonic Acid; Corticosterone; Cyclic AMP; Dopamine; Fenoldopam; Kidney Cortex; Kidney Tubules, Collecting; Male; Phospholipases A; Phospholipases A2; Protein Kinase Inhibitors; Quinacrine; Rats; Rats, Inbred Strains; Signal Transduction; Sodium-Potassium-Exchanging ATPase | 1992 |
Arachidonic acid and prostaglandin E2 activate small-conductance Cl- channels in the basolateral membrane of rabbit parietal cells.
Topics: Animals; Arachidonic Acid; Chlorine; Dinoprostone; Dose-Response Relationship, Drug; Indomethacin; Ion Channels; Male; Membrane Potentials; Nitrobenzoates; Parietal Cells, Gastric; Quinacrine; Rabbits; Umbelliferones | 1992 |
Phospholipase-A2 action and arachidonic acid metabolism in calcium-mediated parathyroid hormone secretion.
Topics: Acetophenones; Animals; Arachidonic Acid; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Flavanones; Flavonoids; Ibuprofen; Indomethacin; Lipoxygenase Inhibitors; Masoprocol; Parathyroid Glands; Parathyroid Hormone; Phospholipases A; Phospholipases A2; Pyrazoles; Quinacrine; Swine; Time Factors; Tritium | 1992 |
Role of arachidonic acid metabolism on corticotropin-releasing factor (CRF)-release induced by interleukin-1 from superfused rat hypothalami.
Topics: Animals; Arachidonic Acid; Corticotropin-Releasing Hormone; Dinoprost; Hypothalamus; Indomethacin; Interleukin-1; Male; Perfusion; Quinacrine; Rats; Rats, Inbred Strains | 1992 |
Modulation of the beta-adrenergic response in cultured rat heart cells. I. Beta-adrenergic supersensitivity is induced by lactate via a phospholipase A2 and 15-lipoxygenase involving pathway.
Topics: Acetophenones; Animals; Arachidonic Acid; Arachidonic Acids; Cells, Cultured; Chronobiology Phenomena; Dose-Response Relationship, Drug; Enzyme Activation; Heart; Hydroxyeicosatetraenoic Acids; Isoproterenol; Lactates; Leukotrienes; Melitten; Phospholipases A; Phospholipases A2; Prostaglandins D; Quinacrine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta | 1991 |
[A pharmacological study on the mechanism of the endothelin-induced contraction of the bovine cerebral artery].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Cattle; Cerebral Arteries; Endothelins; Female; In Vitro Techniques; Isoquinolines; Male; Muscle Contraction; Muscle, Smooth, Vascular; Piperazines; Quinacrine; Sarcoplasmic Reticulum; Sodium Channels; Tetrodotoxin; Vasoconstriction | 1991 |
Release of arachidonic acid and the effects of corticosteroids on steroidogenesis in rat testis Leydig cells.
Topics: Adrenal Cortex Hormones; Animals; Arachidonic Acid; Chromatography, High Pressure Liquid; Cyclic AMP; Dexamethasone; Leydig Cells; Luteinizing Hormone; Male; Phospholipases A; Phospholipases A2; Quinacrine; Radioimmunoassay; Rats; Steroids; Testosterone | 1991 |
Characteristics of phosphoinositide-specific phospholipase C activity from mouse pancreatic islets.
Topics: Animals; Arachidonic Acid; Calcium; Chlorpromazine; Cyclic AMP; Glucose; Glyceraldehyde 3-Phosphate; Indomethacin; Islets of Langerhans; Male; Mice; Phosphatidylinositols; Putrescine; Quinacrine; Spermine; Substrate Specificity; Tetracaine; Type C Phospholipases | 1991 |
Somatostatin potentiates the alpha 1-adrenergic activation of phospholipase C in striatal astrocytes through a mechanism involving arachidonic acid and glutamate.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Arachidonic Acid; Astrocytes; Calcium; Cells, Cultured; Corpus Striatum; Embryo, Mammalian; Enzyme Activation; Glutamates; Inositol Phosphates; Kinetics; Methoxamine; Mice; Models, Neurological; Pertussis Toxin; Quinacrine; Receptors, Adrenergic, alpha; Somatostatin; Type C Phospholipases; Virulence Factors, Bordetella | 1991 |
The differential contribution of endogenous prostaglandins to the release of acetylcholine from the myenteric plexus of the guinea-pig ileum.
Topics: Acetylcholine; Animals; Arachidonic Acid; Arachidonic Acids; Dimethylphenylpiperazinium Iodide; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Indomethacin; Male; Myenteric Plexus; Prostaglandins; Quinacrine; Serotonin; Substance P | 1991 |
Evidence for an involvement of eicosanoids in neurokinin3-receptor mediated acetylcholine release from myenteric neurons.
Topics: Acetylcholine; Animals; Arachidonic Acid; Eicosanoids; Guinea Pigs; In Vitro Techniques; Masoprocol; Muscle, Smooth; Myenteric Plexus; Neurons; Peptide Fragments; Phospholipases A; Phospholipases A2; Quinacrine; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Receptors, Serotonin; Substance P | 1991 |
Resistance to cytolysis by tumor necrosis factor alpha in malignant gynecological cell lines is associated with the expression of protein(s) that prevent the activation of phospholipase A2 by tumor necrosis factor alpha.
Topics: Animals; Arachidonic Acid; Cell Line; Cell Survival; Drug Resistance; Emetine; Female; Humans; Mice; Neoplasm Proteins; Ovarian Neoplasms; Phospholipases A; Phospholipases A2; Quinacrine; Recombinant Proteins; Tumor Necrosis Factor-alpha; Uterine Cervical Neoplasms | 1992 |
Arachidonic acid is essential for IgG Fc receptor-mediated phagocytosis by human monocytes.
Topics: Acetophenones; Antigen-Antibody Complex; Antigens, Differentiation; Arachidonic Acid; Arachidonic Acids; Complement C3b; Eicosanoids; Humans; Immunoglobulin G; In Vitro Techniques; Monocytes; Phagocytosis; Phospholipases; Quinacrine; Receptors, Fc; Receptors, IgG; Signal Transduction; Structure-Activity Relationship; Terpenes; Yeasts | 1991 |
Glucose transport stimulation by bradykinin in Swiss 3T3 fibroblasts: a pertussis toxin-sensitive mechanism operates without involvement of arachidonic acid and cyclic AMP.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Arachidonic Acid; Arachidonic Acids; Biological Transport; Bradykinin; Calcium; Cells, Cultured; Cyclic AMP; Deoxyglucose; Fibroblasts; Glucose; Indomethacin; Insulin; Mice; Pertussis Toxin; Phorbol Esters; Quinacrine; Receptors, Bradykinin; Receptors, Neurotransmitter; Tritium; Virulence Factors, Bordetella | 1991 |
Canatoxin, a plant protein, induces insulin release from isolated pancreatic islets.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Dose-Response Relationship, Drug; Female; Glucose; In Vitro Techniques; Insulin; Islets of Langerhans; Lectins; Osmolar Concentration; Plant Proteins; Quinacrine; Rats; Rats, Inbred Strains; Time Factors; Toxins, Biological | 1991 |
Characterization of CoA-independent transacylase activity in U937 cells.
Topics: Acyltransferases; Arachidonic Acid; Arachidonic Acids; Aristolochic Acids; Cell Line; Chromatography, High Pressure Liquid; Dexamethasone; Diethyl Pyrocarbonate; Edetic Acid; Humans; Hydrogen-Ion Concentration; Microsomes; Phenanthrenes; Quinacrine | 1991 |
Observations on the pharmacology of thalicminine, an oxyaporphine alkaloid from Thalictrum isopyroides.
Topics: Animals; Aorta, Thoracic; Aporphines; Arachidonic Acid; Arachidonic Acids; Blood Pressure; Epinephrine; Guinea Pigs; Heart Rate; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Plants, Medicinal; Propranolol; Pulmonary Artery; Quinacrine; Trachea | 1991 |
Lipid peroxide makes rabbit platelet hyperaggregable to agonists through phospholipase A2 activation.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Calcium; Cyclooxygenase Inhibitors; Enzyme Activation; Ferrous Compounds; Indomethacin; Lipid Peroxidation; Lysophosphatidylcholines; Peroxides; Phospholipases A; Phospholipases A2; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Quinacrine; Rabbits; tert-Butylhydroperoxide; Vitamin E | 1991 |
Possible role of leukotrienes in hypoxic contraction of canine isolated basilar artery.
Topics: Animals; Arachidonic Acid; Basilar Artery; Dogs; Female; Hypoxia; In Vitro Techniques; Leukotriene Antagonists; Leukotrienes; Male; Masoprocol; Muscle Contraction; Muscle, Smooth, Vascular; Propionates; Quinacrine; Quinolines; SRS-A | 1991 |
Phospholipase A2 and mediation of the activation of short-circuit current in the rat colonic mucosa.
Topics: Animals; Arachidonic Acid; Atropine; Bradykinin; Colforsin; Colon; Dose-Response Relationship, Drug; Drug Interactions; Female; Indomethacin; Intestinal Mucosa; Masoprocol; Melitten; Phospholipases A; Phospholipases A2; Quinacrine; Rats; Rats, Inbred Strains; Tetrodotoxin | 1991 |
[Inhibitors for enzymes involving arachidonate cascade].
Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acid; Cyclooxygenase Inhibitors; Leukotrienes; Lipoxygenase Inhibitors; Membrane Lipids; Methacrylates; Phospholipases A; Phospholipids; Prostaglandins; Quinacrine; Terpenes; Thromboxane-A Synthase | 1991 |
Arachidonic acid metabolites as mediators of somatostatin-induced increase of neuronal M-current.
Topics: Acetophenones; Action Potentials; Animals; Arachidonic Acid; Arachidonic Acids; Cyclooxygenase Inhibitors; Electric Conductivity; Hippocampus; Lipoxygenase; Lipoxygenase Inhibitors; Masoprocol; Membrane Potentials; Neurons; Phospholipases A; Phospholipases A2; Potassium; Quinacrine; Rats; Second Messenger Systems; Somatostatin; SRS-A | 1990 |
Role of arachidonic acid or its metabolites in growth-hormone-releasing factor-induced release of somatostatin from the median eminence.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Growth Hormone-Releasing Hormone; Indomethacin; Kinetics; Lipoxygenase Inhibitors; Male; Masoprocol; Median Eminence; Metyrapone; Phospholipases A; Phospholipases A2; Quinacrine; Rats; Rats, Inbred Strains; Somatostatin | 1990 |
Mechanism of human lymphotoxin and tumor necrosis factor induced destruction of cells in vitro: phospholipase activation and deacylation of specific-membrane phospholipids.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cell Survival; Dexamethasone; Enzyme Activation; Humans; Hydrocortisone; Indomethacin; Lymphotoxin-alpha; Membrane Lipids; Mice; Phospholipases; Phospholipids; Quinacrine; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1990 |
Inhibitors of lipoxygenase have antiproliferative effects on P815 murine mastocytoma cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cell Division; Indomethacin; Leukotrienes; Lipoxygenase; Lipoxygenase Inhibitors; Masoprocol; Mast-Cell Sarcoma; Mice; Phospholipases A; Quinacrine; Tumor Cells, Cultured | 1990 |
Distension-induced secretion in the rat colon: mediation by prostaglandins and submucosal neurons.
Topics: Animals; Anthracenes; Arachidonic Acid; Arachidonic Acids; Atropine; Bufanolides; Capsaicin; Colon; Electrophysiology; Female; Half-Life; Indomethacin; Intestinal Mucosa; Neurons; Phospholipases A; Phospholipases A2; Prostaglandins; Quinacrine; Rats; Rats, Inbred Strains; Tetrodotoxin | 1990 |
Regulation of prostaglandin E2 synthesis in human amnion by protein kinase C.
Topics: Amnion; Arachidonic Acid; Arachidonic Acids; Cells, Cultured; Dinoprostone; Dose-Response Relationship, Drug; Gene Expression Regulation; Humans; Membrane Lipids; Phorbol Esters; Phospholipases A; Phospholipases A2; Protein Kinase C; Quinacrine; Stimulation, Chemical; Structure-Activity Relationship | 1990 |
Mobilization of arachidonic acid in thrombin-stimulated human platelets.
Topics: Arachidonic Acid; Arachidonic Acids; Blood Platelets; Carbamates; Esterases; Fatty Acids, Nonesterified; Humans; In Vitro Techniques; Phenylcarbamates; Phenylmethylsulfonyl Fluoride; Phosphatidic Acids; Phosphatidylcholines; Phospholipases A; Phospholipases A2; Phospholipids; Quinacrine; Thrombin | 1990 |
Ischemia and reperfusion induced formation of eicosanoids in isolated rat hearts.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Coronary Disease; Eicosanoids; Fatty Acids; Hemodynamics; In Vitro Techniques; L-Lactate Dehydrogenase; Male; Myocardial Reperfusion; Myocardium; Quinacrine; Rats; Rats, Inbred Lew | 1990 |
Phospholipase A2 activation and autoinduction of tumor necrosis factor gene expression by tumor necrosis factor.
Topics: Acetophenones; Arachidonic Acid; Arachidonic Acids; Blotting, Northern; Choline; Enzyme Activation; Gene Expression Regulation, Neoplastic; Humans; In Vitro Techniques; Inositol Phosphates; Leukemia, Myeloid; Lipoxygenase Inhibitors; Lysophosphatidylcholines; Phospholipases A; Phospholipases A2; Precipitin Tests; Quinacrine; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Type C Phospholipases | 1990 |
Relationship between arachidonic acid release and Ca2(+)-dependent exocytosis in digitonin-permeabilized bovine adrenal chromaffin cells.
Topics: Adrenal Glands; Alkaloids; Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Cattle; Cell Membrane Permeability; Chromaffin Granules; Cyclohexanones; Digitonin; Ethylmaleimide; Exocytosis; Indomethacin; Phospholipases A; Phospholipases A2; Protein Kinase C; Quinacrine; Staurosporine | 1990 |
Exposure to N-methyl-D-aspartate increases release of arachidonic acid in primary cultures of rat hippocampal neurons and not in astrocytes.
Topics: Adenosine Triphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Astrocytes; Calcium; Cells, Cultured; Hippocampus; Masoprocol; N-Methylaspartate; Neurons; Phospholipases A; Phospholipases A2; Quinacrine; Rats | 1990 |
Characterization of distinct phospholipases mediating bradykinin and noradrenaline hyperalgesia.
Topics: Aminoquinolines; Animals; Arachidonic Acid; Arachidonic Acids; Bradykinin; Calcimycin; Fluorescent Dyes; Hyperalgesia; Male; Neomycin; Nociceptors; Norepinephrine; Phospholipases A; Phospholipases A2; Quinacrine; Rats; Rats, Inbred Strains; Skin; Type C Phospholipases; Verapamil | 1990 |
Regulation of arachidonic acid release by enzyme(s) of rat brain cortex.
Topics: Arachidonic Acid; Arachidonic Acids; Calcium Chloride; Carbon Radioisotopes; Cerebral Cortex; Egtazic Acid; Kinetics; Neomycin; Phospholipases A; Phospholipases A2; Phospholipids; Quinacrine; Type C Phospholipases | 1990 |
Human cytomegalovirus stimulates arachidonic acid metabolism through pathways that are affected by inhibitors of phospholipase A2 and protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Arachidonic Acid; Arachidonic Acids; Cells, Cultured; Cytomegalovirus; Cytomegalovirus Infections; Diacylglycerol Kinase; Humans; In Vitro Techniques; Isoquinolines; Lipase; Phospholipases; Phospholipases A; Phospholipases A2; Phosphotransferases; Piperazines; Protein Kinase C; Quinacrine; Tetracaine; Tetradecanoylphorbol Acetate | 1990 |
Evidence for coupling of different receptors for gonadotropin-releasing hormone to phospholipases C and A2 in cultured rat luteal cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Cells, Cultured; Corpus Luteum; Dinoprost; Enzyme Activation; Female; Gonadotropin-Releasing Hormone; Phospholipases; Phospholipases A; Phospholipids; Quinacrine; Rats; Rats, Inbred Strains; Receptors, LHRH; Signal Transduction; Type C Phospholipases | 1990 |
N-methyl-D-aspartate-sensitive glutamate receptors induce calcium-mediated arachidonic acid release in primary cultures of cerebellar granule cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspartic Acid; Calcium; Cells, Cultured; Cerebellum; Cholera Toxin; Glutamates; Granulocytes; Ionomycin; N-Methylaspartate; Phospholipases A; Phospholipases A2; Quinacrine; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Type C Phospholipases; Virulence Factors, Bordetella | 1990 |
G alpha i-3 regulates epithelial Na+ channels by activation of phospholipase A2 and lipoxygenase pathways.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cell Compartmentation; Cell Line; Cell Membrane; Enzyme Activation; Epithelium; GTP-Binding Proteins; In Vitro Techniques; Kidney; Leukotrienes; Lipoxygenase; Masoprocol; Melitten; Pertussis Toxin; Phospholipases A; Phospholipases A2; Quinacrine; Signal Transduction; Sodium Channels; SRS-A; Virulence Factors, Bordetella; Xenopus | 1990 |
A comparison of the antitumor effects of natural human tumor necrosis factors alpha and beta: the roles of arachidonic acid metabolism and intracellular cAMP.
Topics: Arachidonic Acid; Arachidonic Acids; Breast Neoplasms; Colforsin; Colonic Neoplasms; Cyclic AMP; Dexamethasone; Female; Humans; Indomethacin; Lymphotoxin-alpha; Metyrapone; Phospholipases A; Phospholipases A2; Quinacrine; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1990 |
Captopril-induced increase in coronary flow: an SH-dependent effect on arachidonic acid metabolism?
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Bridged Bicyclo Compounds; Captopril; Chromones; Coronary Circulation; Glutathione; In Vitro Techniques; Indomethacin; Male; Quinacrine; Ramipril; Rats; Rats, Inbred Strains; Sulfhydryl Compounds | 1987 |
Increase of phosphatidylinositol arachidonic acid incorporation induced by mepacrine.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Coenzyme A; Dose-Response Relationship, Drug; In Vitro Techniques; Kidney Medulla; Phosphatidylinositols; Phospholipids; Quinacrine; Rats; Rats, Inbred Strains | 1989 |
Factors subserving the enhancing effect of progesterone on the output of prostaglandin F2 alpha in uteri from ovariectomized rats.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Dinoprost; Female; Nifedipine; Ovariectomy; Progesterone; Prostaglandins E; Quinacrine; Rats; Rats, Inbred Strains; Uterus | 1989 |
Mepacrine attenuates pulmonary vasoreactivity in rabbits.
Topics: Angiotensin II; Animals; Arachidonic Acid; Arachidonic Acids; Male; Peroxides; Potassium Chloride; Pulmonary Artery; Quinacrine; Rabbits; tert-Butylhydroperoxide; Vasoconstriction | 1989 |
Mechanism of membrane phospholipid degradation in ischemic-reperfused rat hearts.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Coronary Disease; Fatty Acids, Nonesterified; Glycerol; Male; Membrane Lipids; Myocardial Reperfusion; Myocardium; Phospholipids; Quinacrine; Rats; Rats, Inbred Strains; Trifluoperazine; Verapamil | 1989 |
Effects of mepacrine on the oxidation of [1-14C]oleate in isolated rat hepatocytes.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Carbon Dioxide; In Vitro Techniques; Liver; Male; Oleic Acids; Oxidation-Reduction; Quinacrine; Rats | 1989 |
Cellular responses to Pyrularia thionin are mediated by Ca2+ influx and phospholipase A2 activation and are inhibited by thionin tyrosine iodination.
Topics: Animals; Antimicrobial Cationic Peptides; Arachidonic Acid; Arachidonic Acids; Calcium; Cell Line; Cell Survival; Cells, Cultured; Dexamethasone; Enzyme Activation; Hemolysis; Humans; Indomethacin; Iodides; Membrane Potentials; Mice; Muscles; Phospholipases; Phospholipases A; Phospholipases A2; Plant Proteins; Quinacrine; Seeds; Tyrosine | 1989 |
Association between inhibition of arachidonic acid release and prevention of calcium loading during ATP depletion in cultured rat cardiac myocytes.
Topics: Adenosine Triphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Cells, Cultured; Coronary Disease; Electron Probe Microanalysis; Estrenes; Heart; Phospholipases A; Quinacrine; Rats | 1989 |
Arachidonic acid mobilization and phosphoinositide turnover by the terminal complement complex, C5b-9, in rat oligodendrocyte x C6 glioma cell hybrids.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Calcium; Clone Cells; Complement Membrane Attack Complex; Complement System Proteins; Glioma; Humans; Hybrid Cells; Isoquinolines; Neuroglia; Oligodendroglia; Phosphatidylinositols; Piperazines; Protein Kinase C; Quinacrine; Rats | 1989 |
No role for phospholipase A2 and protein kinase C in the potentiation by alpha-adrenoceptors of beta-adrenoceptor-mediated cyclic AMP formation in rat brain.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Brain; Cyclic AMP; Cyclooxygenase Inhibitors; Lipoxygenase Inhibitors; Male; Melitten; Phospholipases; Phospholipases A; Phospholipases A2; Protein Kinase C; Quinacrine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Vasoactive Intestinal Peptide | 1989 |
Release of vasoactive intestinal peptide in mouse cerebral cortex: evidence for a role of arachidonic acid metabolites.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Cerebral Cortex; Chromatography, High Pressure Liquid; Lipoxygenase Inhibitors; Male; Melitten; Mice; Quinacrine; Tetrodotoxin; Vasoactive Intestinal Peptide | 1989 |
Bradykinin-increased phospholipid deacylation-reacylation in rat renal medulla is inhibited by dBc AMP.
Topics: Acylation; Animals; Arachidonic Acid; Arachidonic Acids; Bradykinin; Bucladesine; Kidney Medulla; Phospholipids; Quinacrine; Rats | 1989 |
Superoxide generation is inhibited by phospholipase A2 inhibitors. Role for phospholipase A2 in the activation of the NADPH oxidase.
Topics: Acetophenones; Amino Alcohols; Arachidonic Acid; Arachidonic Acids; Cell-Free System; Enzyme Activation; Humans; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Phospholipases; Phospholipases A; Phospholipases A2; Quinacrine; Sodium Dodecyl Sulfate; Superoxides; Tetradecanoylphorbol Acetate | 1989 |
Growth hormone releasing factor (GRF) increases free arachidonate levels in the pituitary: a role for lipoxygenase products.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acid; Arachidonic Acids; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Growth Hormone-Releasing Hormone; Indomethacin; Lipoxygenase; Lipoxygenase Inhibitors; Male; Peptide Fragments; Pituitary Gland; Pyrazoles; Quinacrine; Rats; Rats, Inbred Strains; Somatostatin | 1986 |
Activation of purified soluble guanylate cyclase by endothelium-derived relaxing factor from intrapulmonary artery and vein: stimulation by acetylcholine, bradykinin and arachidonic acid.
Topics: Acetylcholine; Animals; Arachidonic Acid; Arachidonic Acids; Atropine; Bradykinin; Cattle; Endothelium; Enzyme Activation; Guanylate Cyclase; Hemoglobins; In Vitro Techniques; Methylene Blue; Nitric Oxide; Proadifen; Pulmonary Artery; Pulmonary Veins; Quinacrine; Solubility; Vasodilator Agents | 1986 |
Activation of alpha 1-adrenoceptors, protein kinase C, or treatment with intracellular free Ca2+ elevating agents increases pineal phospholipase A2 activity. Evidence that protein kinase C may participate in Ca2+-dependent alpha 1-adrenergic stimulation o
Topics: Adrenergic alpha-Agonists; Animals; Arachidonic Acid; Arachidonic Acids; Bucladesine; Calcimycin; Calcium; Diglycerides; Lysophosphatidylcholines; Male; Norepinephrine; Organ Culture Techniques; Ouabain; Ovariectomy; Phenylephrine; Phospholipases; Phospholipases A; Phospholipases A2; Pineal Gland; Potassium; Protein Kinase C; Quinacrine; Rats; Tetradecanoylphorbol Acetate | 1987 |
Two phasic generation of thromboxane A2 by the action of collagen on rat platelets.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Collagen; Dose-Response Relationship, Drug; Indomethacin; Kinetics; Phospholipases; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Prostaglandins, Synthetic; Quinacrine; Rats; Receptors, Prostaglandin; Receptors, Thromboxane; Sulfonamides; Thromboxane A2 | 1987 |
Arachidonate stimulates prolactin release in vitro: a role for the fatty acid and its metabolites as intracellular regulator(s) in mammotrophs.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acid; Arachidonic Acids; Bucladesine; Catechols; Cells, Cultured; Female; In Vitro Techniques; Indomethacin; Lipoxygenase Inhibitors; Masoprocol; Oleic Acid; Oleic Acids; Phospholipases A; Phospholipases A2; Pituitary Gland; Pituitary Gland, Anterior; Prolactin; Pyrazoles; Quinacrine; Rats; Rats, Inbred Strains; Stearic Acids; Tetradecanoylphorbol Acetate | 1985 |
The role of thrombin in the regulation of the endothelial prostaglandin production.
Topics: Arachidonic Acid; Arachidonic Acids; Bromobenzenes; Bucladesine; Calcimycin; Carbon Radioisotopes; Endothelium; Female; Humans; Kinetics; Muscle, Smooth, Vascular; Pregnancy; Prostaglandins; Quinacrine; Thrombin; Umbilical Veins | 1985 |
Bradykinin stimulation of oxidative metabolism in renal cortical tubules from rabbit. Possible role of arachidonic acid.
Topics: Adenine Nucleotides; Animals; Antimycin A; Arachidonic Acid; Arachidonic Acids; Bradykinin; Calcium; Kidney Cortex; Kidney Tubules; Mitochondria; Oligomycins; Oxygen Consumption; Quinacrine; Rabbits; Rotenone; Sodium-Potassium-Exchanging ATPase | 1985 |
[Development of a method for the study of drugs which inhibit phospholipase A2].
Topics: Arachidonic Acid; Arachidonic Acids; Calcium; Chemistry, Pharmaceutical; Chromatography, Thin Layer; Phosphodiesterase I; Phosphodiesterase Inhibitors; Phospholipases; Phospholipases A; Phospholipases A2; Phosphoric Diester Hydrolases; Quinacrine | 1985 |
Effect of various blockers of arachidonic acid metabolism on release of beta-endorphin- and adrenocorticotropin-like immunoreactivity induced by phospholipase A2 from rat adenohypophysis in vitro.
Topics: Acetophenones; Adrenocorticotropic Hormone; Animals; Arachidonic Acid; Arachidonic Acids; beta-Endorphin; Cobalt; Endorphins; In Vitro Techniques; Indomethacin; Male; Phospholipases; Phospholipases A; Phospholipases A2; Pituitary Gland, Anterior; Quinacrine; Radioimmunoassay; Rats; Rats, Inbred Strains | 1986 |
Activation of NADPH-oxidase by arachidonic acid involves phospholipase A2 in intact human neutrophils but not in the cell-free system.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Arachidonic Acid; Arachidonic Acids; Cell-Free System; Cyclooxygenase Inhibitors; Enzyme Activation; Humans; Isoquinolines; Lipoxygenase Inhibitors; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Oleic Acid; Oleic Acids; Phospholipases A; Phospholipases A2; Piperazines; Prostaglandin Endoperoxides, Synthetic; Protein Kinase C; Quinacrine; Superoxides; Tretoquinol | 1986 |
Differential effects of mepacrine, chloroquine and hydroxychloroquine on superoxide anion generation, phospholipid methylation and arachidonic acid release by human blood monocytes.
Topics: Arachidonic Acid; Arachidonic Acids; Calcimycin; Cell Survival; Chloroquine; Fluorides; Humans; Hydroxychloroquine; Monocytes; N-Formylmethionine Leucyl-Phenylalanine; Phospholipids; Quinacrine; Superoxides; Tetradecanoylphorbol Acetate; Zymosan | 1986 |
Ionophore A23187 stimulates arachidonic acid release and cyclic GMP accumulation in pig epidermis.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Calcium; Culture Techniques; Cyclic GMP; Epidermis; Quinacrine; Swine | 1986 |
Effects of inhibitors of arachidonic acid metabolism on intercellular adhesion of SV40-3T3 cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Catechols; Cell Aggregation; Cell Transformation, Viral; Cells, Cultured; Cyclooxygenase Inhibitors; Indomethacin; Masoprocol; Mice; Quinacrine; Simian virus 40 | 1986 |
Identification of distinct activation pathways of the human neutrophil NADPH-oxidase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Arachidonic Acid; Arachidonic Acids; Aspirin; Calcium; Enzyme Activation; Humans; Indomethacin; Isoquinolines; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Phospholipases A; Phospholipases A2; Phospholipids; Piperazines; Pyrazoles; Quinacrine; Superoxides; Tetradecanoylphorbol Acetate; Zymosan | 1986 |
Induction of prostacyclin biosynthesis is closely associated with increased guanosine 3',5'-cyclic monophosphate accumulation in cultured human endothelium.
Topics: Arachidonic Acid; Arachidonic Acids; Bradykinin; Calcimycin; Cells, Cultured; Cyclic GMP; Endothelium; Epoprostenol; Histamine; Humans; Kinetics; Quinacrine; Thrombin; Umbilical Veins | 1986 |
The role of polyphosphoinositides and their breakdown products in A23187-induced release of arachidonic acid from rabbit polymorphonuclear leucocytes.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Lipids; Male; Models, Biological; Neutrophils; Phosphatidylinositol Phosphates; Phosphatidylinositols; Phospholipases A; Phospholipases A2; Quinacrine; Rabbits; Stimulation, Chemical | 1986 |
Contribution of Ca++ and calmodulin to the action of norepinephrine on renal prostaglandin synthesis and vascular tone.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Blood Pressure; Calcium; Calcium Channel Blockers; Calmodulin; Indomethacin; Kidney; Male; Norepinephrine; Perfusion; Prazosin; Prostaglandins; Quinacrine; Rats; Rats, Inbred Strains; Trifluoperazine; Vasoconstriction | 1986 |
Effect of verapamil on prostaglandin E2 synthesis by hydronephrotic rabbit cortical interstitial cells in primary culture.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Bradykinin; Calcimycin; Calcium; Cells, Cultured; Diltiazem; Dinoprostone; Dose-Response Relationship, Drug; Hydronephrosis; Kidney Cortex; Magnesium; Male; Nifedipine; Prostaglandins E; Quinacrine; Rabbits; Trifluoperazine; Verapamil | 1986 |
Endothelium-dependent inhibition of platelet aggregation.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Arachidonic Acid; Arachidonic Acids; Catechols; Endothelium; In Vitro Techniques; Indomethacin; Male; Masoprocol; Perfusion; Platelet Aggregation; Quinacrine; Rabbits; Vasodilation | 1986 |
Enhanced prostaglandin synthesis due to phospholipid breakdown in ischemic-reperfused myocardium. Control of its production by a phospholipase inhibitor or free radical scavengers.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Arachidonic Acids; Catalase; Female; Heart; Ischemia; Male; Myocardium; Phospholipids; Prostaglandins; Quinacrine; Superoxide Dismutase; Swine; Thromboxane B2 | 1986 |
Inositol phospholipids are probably not the source of arachidonic acid for eicosanoid synthesis in astrocytes.
Topics: Animals; Animals, Newborn; Arachidonic Acid; Arachidonic Acids; Astrocytes; Calcimycin; Carbachol; Cells, Cultured; Cerebral Cortex; Eicosanoic Acids; Inositol; Inositol Phosphates; Kinetics; Norepinephrine; Phosphatidylinositols; Quinacrine; Rats; Sugar Phosphates | 1987 |
Possible involvement of the phospholipases in the mitogenic actions of prolactin (PRL) on Nb2 node lymphoma cells.
Topics: Acetophenones; Animals; Arachidonic Acid; Arachidonic Acids; Cell Division; Cell Line; Lymphoma; Phospholipases; Phospholipases A; Phospholipases A2; Prolactin; Quinacrine; Rats; Stimulation, Chemical; Type C Phospholipases | 1987 |
Stimulation of luteinizing hormone release by melittin and phospholipase A2 in rat pituitary cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Bee Venoms; Cell Membrane; Cells, Cultured; Chloroquine; Dose-Response Relationship, Drug; Enzyme Activation; Female; Gonadotropin-Releasing Hormone; In Vitro Techniques; Luteinizing Hormone; Melitten; Phospholipases; Phospholipases A; Phospholipases A2; Pituitary Gland, Anterior; Quinacrine; Rats; Secretory Rate | 1987 |
Glucocorticoids inhibit the liberation of arachidonate but not the rapid production of phospholipase C-dependent metabolites in acetylcholine-stimulated C62B glioma cells.
Topics: Acetylcholine; Animals; Arachidonic Acid; Arachidonic Acids; Cell Line; Cells, Cultured; Dexamethasone; Glioma; Glucocorticoids; Lipid Metabolism; Phosphatidic Acids; Quinacrine; Type C Phospholipases | 1987 |
The inhibitory action of quinacrine on endotoxin-induced tissue factor expression in cultured human endothelial cells is due to cell injury.
Topics: Adenine; Arachidonic Acid; Arachidonic Acids; Blood Coagulation Factors; Cells, Cultured; Endothelium; Endotoxins; Epoprostenol; Humans; L-Lactate Dehydrogenase; Phospholipases A; Quinacrine; Radioimmunoassay; Thromboplastin; Tritium | 1987 |
Nature of endothelium-derived relaxing factor: are there two relaxing mediators?
Topics: Acetylcholine; Animals; Arachidonic Acid; Arachidonic Acids; Biological Assay; Biological Products; Coronary Vessels; Cytochrome P-450 Enzyme Inhibitors; Dogs; Endothelium; Female; Lipoxygenase; Lipoxygenase Inhibitors; Male; Masoprocol; Metyrapone; Muscle Relaxation; Nitric Oxide; Phospholipases A; Phospholipases A2; Quinacrine | 1987 |
Phorbol ester stimulation of prostanoid synthesis by cultured astrocytes.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Astrocytes; Calcimycin; Calcium; Cells, Cultured; Cerebral Cortex; Prostaglandins; Protein Kinase C; Quinacrine; Rats; Tetradecanoylphorbol Acetate | 1987 |
Platelet-activating factor (PAF-acether) formation in rat basophilic leukemia cells stimulated by ionophore A23187.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Basophils; Calcimycin; Leukemia, Experimental; Platelet Activating Factor; Quinacrine; Rats | 1987 |
A major role for phospholipase A2 in antigen-induced arachidonic acid release in rat mast cells.
Topics: Animals; Antigens; Antigens, Helminth; Arachidonic Acid; Arachidonic Acids; Fatty Acids, Nonesterified; Lipid Metabolism; Mast Cells; Phospholipases; Phospholipases A; Phospholipases A2; Quinacrine; Rats; Rats, Inbred Strains | 1987 |
Effects of interleukin-1 and arachidonate on the preoptic and anterior hypothalamic neurons.
Topics: Animals; Anterior Hypothalamic Nucleus; Arachidonic Acid; Arachidonic Acids; Cold Temperature; Hot Temperature; Interleukin-1; Male; Neurons; Preoptic Area; Quinacrine; Rats; Rats, Inbred Strains; Salicylates; Salicylic Acid | 1988 |
Modulation of acetylcholine release from guinea-pig Ileum myenteric plexus by arachidonic acid cascade inhibitors.
Topics: Acetylcholine; Animals; Arachidonic Acid; Arachidonic Acids; Dinoprostone; Guinea Pigs; Ileum; In Vitro Techniques; Indomethacin; Male; Myenteric Plexus; Nicotine; Phospholipases A; Prostaglandins E; Quinacrine | 1987 |
The mechanism of the inhibitory effects of antimalarials on UV-induced skin inflammation in mice.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Chloroquine; Ear, External; Edema; Female; Inflammation; Mice; Mice, Inbred ICR; PUVA Therapy; Quinacrine; Skin; Ultraviolet Rays | 1988 |
Exogenous arachidonic acid promotes insulin release from intact or permeabilized rat islets by dual mechanisms. Putative activation of Ca2+ mobilization and protein kinase C.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Calcium Radioisotopes; Cell Membrane Permeability; Cold Temperature; Dantrolene; Digitonin; Drug Synergism; Enzyme Activation; Ethers; Glucose; Insulin; Insulin Secretion; Ionomycin; Islets of Langerhans; Kinetics; Protein Kinase C; Quinacrine; Rats; Sodium; Tetradecanoylphorbol Acetate; Trifluoperazine | 1988 |
Selective inhibition of free arachidonic acid production in activated alveolar macrophages by calmodulin antagonists.
Topics: Acetophenones; Animals; Arachidonic Acid; Arachidonic Acids; Calmodulin; Chlorpromazine; Chromatography, High Pressure Liquid; Cytochalasin B; Linoleic Acid; Linoleic Acids; Macrophage Activation; Macrophages; Oleic Acid; Oleic Acids; Opsonin Proteins; Phosphatidylcholines; Phosphatidylinositols; Phospholipases A; Pulmonary Alveoli; Quinacrine; Rabbits; Sulfonamides; Trifluoperazine; Zymosan | 1988 |
Effects of retinoids and inhibitors of arachidonic acid metabolism on tumor-promoter-induced soft agar colony formation of mouse epidermal cells and rat urinary bladder cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Colony-Forming Units Assay; Diterpenes; Epidermis; Female; Male; Masoprocol; Mice; Quinacrine; Rats; Rats, Inbred F344; Retinoids; Retinyl Esters; Saccharin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Stem Cell Assay; Urinary Bladder Neoplasms; Vitamin A | 1988 |
Depolarization-induced [3H]arachidonic acid accumulation: effects of external Ca2+ and phospholipase inhibitors.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcium Channel Blockers; Cerebellum; Dibucaine; Enzyme Inhibitors; Phospholipases; Quinacrine; Rats; Verapamil | 1988 |
Acetyl glycerylphosphorylcholine aggregates human platelets through two distinct pathways, both dependent on arachidonic acid metabolism.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Catechols; Chromatography, Thin Layer; Cyclooxygenase Inhibitors; Humans; Imidazoles; In Vitro Techniques; Lipoxygenase Inhibitors; Masoprocol; Phospholipases; Platelet Activating Factor; Platelet Aggregation; Prostanoic Acids; Quinacrine; Radioimmunoassay; Receptors, Prostaglandin; Receptors, Thromboxane; Thromboxane A2; Thromboxane-A Synthase | 1985 |
CoA-independent transfer of arachidonic acid from 1,2-diacyl-sn-glycero-3-phosphocholine to 1-O-alkyl-sn-glycero-3-phosphocholine (lyso platelet-activating factor) by macrophage microsomes.
Topics: Adenosine Triphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Cholic Acid; Cholic Acids; Coenzyme A; Macrophages; Magnesium; Microsomes; Phosphatidylcholines; Platelet Activating Factor; Quinacrine; Rabbits | 1985 |
Effect of inhibitors of proteolysis and arachidonic acid metabolism on burn-induced protein breakdown.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Burns; Hindlimb; Ibuprofen; In Vitro Techniques; Indomethacin; Leupeptins; Lysosomes; Muscles; Oligopeptides; Peptide Hydrolases; Protease Inhibitors; Proteins; Quinacrine; Rats; Rats, Inbred Strains; Tyrosine | 1985 |
Possible role of phospholipase A2 action and arachidonic acid metabolism in angiotensin II-mediated aldosterone secretion.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; 5,8,11,14-Eicosatetraynoic Acid; Acetophenones; Aldosterone; Angiotensin II; Animals; Arachidonic Acid; Arachidonic Acids; Caffeic Acids; Calcium; Cattle; Cyclooxygenase Inhibitors; Dantrolene; Dose-Response Relationship, Drug; Indomethacin; Lipoxygenase Inhibitors; Phospholipases; Phospholipases A; Phospholipases A2; Pyrazoles; Quinacrine | 1985 |
Involvement of arachidonate metabolism in neurotensin-induced prolactin release in vitro.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Cyclohexanones; Female; In Vitro Techniques; Kinetics; Lipoprotein Lipase; Neurotensin; Pituitary Gland; Prolactin; Pyrazoles; Quinacrine; Rats; Rats, Inbred Strains; Tritium | 1985 |
The effect of angiotensin II on arachidonate metabolism in adrenal glomerulosa cells.
Topics: Adrenal Glands; Angiotensin II; Animals; Arachidonic Acid; Arachidonic Acids; Lithium; Male; Phosphates; Phosphatidylcholines; Phosphatidylethanolamines; Phosphatidylinositols; Phospholipases A; Phospholipases A2; Quinacrine; Rats | 1985 |
Mepacrine (quinacrine) inhibition of thrombin-induced platelet responses can be overcome by lysophosphatidic acid.
Topics: Arachidonic Acid; Arachidonic Acids; Blood Platelets; Humans; Kinetics; Lysophospholipids; Phosphatidic Acids; Platelet Aggregation; Quinacrine; Thrombin | 1985 |
Effect of diarachidonin on prostaglandin E2 synthesis in rabbit kidney medulla slices.
Topics: Acetophenones; Animals; Arachidonic Acid; Arachidonic Acids; Diglycerides; Dinoprostone; Dose-Response Relationship, Drug; Egtazic Acid; Glycerides; In Vitro Techniques; Kidney Medulla; Male; Phosphatidic Acids; Prostaglandins E; Quinacrine; Rabbits | 1985 |
Inhibition of prostaglandin synthesis in rabbit kidney medulla slices by antioxidants.
Topics: Animals; Antioxidants; Arachidonic Acid; Arachidonic Acids; Aspirin; Ditiocarb; In Vitro Techniques; Kidney Medulla; Lipid Peroxides; Male; Phenols; Phenylenediamines; Prostaglandins; Prostaglandins E; Quinacrine; Rabbits; Time Factors | 1984 |
On the role of arachidonic acid metabolites in mast-cell mediated mitogenesis in the rat.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acid; Arachidonic Acids; Cyclooxygenase Inhibitors; DNA; Histamine; Indomethacin; Lipoxygenase Inhibitors; Male; Mast Cells; Mesentery; Mitosis; p-Methoxy-N-methylphenethylamine; Phospholipases A; Phospholipases A2; Prostaglandins; Pyrazoles; Quinacrine; Rats; Rats, Inbred Strains; SRS-A | 1984 |
Phospholipase activation in the IgE-mediated and Ca2+ ionophore A23187-induced release of histamine from rat basophilic leukemia cells.
Topics: Animals; Anti-Bacterial Agents; Arachidonic Acid; Arachidonic Acids; Basophils; Calcimycin; Calcium; Cell Line; Enzyme Activation; Histamine Release; Immunoglobulin E; Indomethacin; Kinetics; Leukemia, Experimental; Phospholipases; Quinacrine; Rats | 1981 |
Phospholipid turnover during phagocytosis in human polymorphonuclear leucocytes.
Topics: 1-Methyl-3-isobutylxanthine; Arachidonic Acid; Arachidonic Acids; Diacylglycerol Cholinephosphotransferase; Humans; In Vitro Techniques; Neutrophils; Phagocytosis; Phosphatidylcholines; Phospholipids; Quinacrine; Zymosan | 1982 |
Irreversible binding of quinacrine to nucleic acids during horseradish peroxidase- and prostaglandin synthetase-catalyzed oxidation.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; DNA; Horseradish Peroxidase; Indomethacin; Kinetics; Male; Microsomes; Oxidation-Reduction; Peroxidases; Prostaglandin-Endoperoxide Synthases; Quinacrine; RNA; Seminal Vesicles; Sheep | 1983 |
The phosphatidylinositol cycle and the regulation of arachidonic acid production.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Bucladesine; Calcimycin; Calcium Chloride; Horses; Kinetics; Phosphatidic Acids; Phosphatidylinositols; Quinacrine; Thrombin | 1981 |
Pharmacologic modulation of release of arachidonic acid from human mononuclear cells and lymphocytes by mitogenic lectins.
Topics: Arachidonic Acid; Arachidonic Acids; Colchicine; Cyclic AMP; Cytochalasin B; Cytochalasins; Filtration; Glucocorticoids; Humans; Lectins; Lymphocytes; Phagocytes; Quinacrine; Time Factors | 1982 |
Stimulation of arachidonic acid metabolism and generation of thromboxane A2 by leukotrienes B4, C4 and D4 in guinea-pig lung in vitro.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Guinea Pigs; Imidazoles; In Vitro Techniques; Leukotriene B4; Lung; Quinacrine; Rabbits; Rats; Rats, Inbred Strains; Species Specificity; SRS-A; Thromboxane A2; Thromboxanes | 1982 |
Studies on the mechanism of alteration by propranolol and mepacrine of the metabolism of phosphoinositides and other glycerolipids in the rabbit iris muscle.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; In Vitro Techniques; Iris; Microsomes; Muscle, Smooth; Phosphatidylinositols; Phospholipids; Propranolol; Quinacrine; Rabbits | 1983 |
Role of Ca2+ in phosphatidylinositol response and arachidonic acid release in formylated tripeptide- or Ca2+ ionophore A23187-stimulated guinea pig neutrophils.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Calcium; Female; Guinea Pigs; Lysophospholipids; N-Formylmethionine; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oligopeptides; Phosphatidylinositols; Phospholipids; Phosphorus Radioisotopes; Quinacrine; Trifluoperazine | 1983 |
Mechanism of complement-induced stimulation of prostacyclin production by isolated rabbit peritoneum.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Arachidonic Acids; Complement C3; Complement C5; Complement System Proteins; Dexamethasone; Epoprostenol; Female; Indomethacin; Male; Molecular Weight; Peptide Fragments; Peritoneum; Prostaglandins; Quinacrine; Rabbits; Trypsin | 1983 |
Enhancement of insulin release due to inhibition of phospholipase A2 activity.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Insulin; Islets of Langerhans; Melitten; Phospholipases; Phospholipases A; Phospholipases A2; Quinacrine; Rats; Rats, Inbred Strains; Tetracaine | 1983 |
Endothelium-dependent relaxation of rabbit aorta. II. Inhibition of relaxation stimulated by methacholine and A23187 with antagonists of arachidonic acid metabolism.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Anti-Bacterial Agents; Aorta, Thoracic; Arachidonic Acid; Arachidonic Acids; Calcimycin; Endothelium; Indomethacin; Isoproterenol; Male; Methacholine Chloride; Methacholine Compounds; Muscle Contraction; Muscle Relaxation; Prostaglandin Antagonists; Quinacrine; Rabbits | 1983 |
Arachidonic acid metabolism and prolactin secretion in vitro: a possible role for the lipoxygenase products.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Catechols; Female; Indomethacin; Lipoxygenase; Masoprocol; Phospholipases A; Phospholipases A2; Pituitary Gland, Anterior; Prolactin; Quinacrine; Rats; Rats, Inbred Strains | 1983 |
The distribution of 14C-arachidonic acid in hamster lungs is sensitive to quinacrine.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Biotransformation; Cricetinae; Fatty Acids, Nonesterified; In Vitro Techniques; Lipid Metabolism; Lung; Male; Mesocricetus; Phospholipids; Quinacrine | 1983 |
Stimulation of anterior pituitary prolactin release by melittin, an activator of phospholipase A2.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Bee Venoms; Biological Transport; Cattle; Cells, Cultured; Indomethacin; Kinetics; Leucine; Melitten; Phospholipases; Phospholipases A; Phospholipases A2; Pituitary Gland, Anterior; Prolactin; Quinacrine; Tritium | 1984 |
Mepacrine blockade of arachidonate-induced washed platelet aggregation: relationship to mepacrine inhibition of platelet cyclooxygenase.
Topics: Arachidonic Acid; Arachidonic Acids; Blood Platelets; Cyclooxygenase Inhibitors; Humans; In Vitro Techniques; Platelet Aggregation; Quinacrine; Thromboxane B2 | 1983 |
Prostaglandin biosynthesis in rabbit kidney: mepacrine inhibits renomedullary cyclooxygenase.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cyclooxygenase Inhibitors; Dinoprost; Dinoprostone; Kidney Medulla; Male; Microsomes; Prostaglandins; Prostaglandins E; Prostaglandins F; Quinacrine; Rabbits | 1984 |
Arachidonic acid metabolism and thyrotropin secretion in vitro.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acid; Arachidonic Acids; Catechols; Female; In Vitro Techniques; Indomethacin; Masoprocol; Phospholipases A; Phospholipases A2; Pituitary Gland; Pyrazoles; Quinacrine; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Thyrotropin; Thyrotropin-Releasing Hormone | 1984 |
Albumin stimulates the release of arachidonic acid from phosphatidylcholine in hamster lungs.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Lung; Male; Phosphatidylcholines; Quinacrine; Serum Albumin, Bovine | 1984 |
Evidence for a role of phospholipase activity in the serum stimulation of Na+ influx in human fibroblasts.
Topics: Amiloride; Arachidonic Acid; Arachidonic Acids; Dexamethasone; Fibroblasts; Humans; Male; Melitten; Mitogens; Phospholipases; Propanolamines; Quinacrine; Sodium | 1984 |
Prostaglandin synthesis linked to phosphatidylinositol turnover in isolated rat glomeruli.
Topics: Angiotensin II; Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Dose-Response Relationship, Drug; Kidney Glomerulus; Male; Phosphates; Phosphatidylinositols; Prostaglandins; Quinacrine; Radioimmunoassay; Rats; Rats, Inbred Strains; Trifluoperazine | 1984 |
Arachidonate metabolism, 5-hydroxytryptamine release and aggregation in human platelets activated by palmitaldehyde acetal phosphatidic acid.
Topics: Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Chlorpromazine; Humans; In Vitro Techniques; Indomethacin; Lipids; Malondialdehyde; Platelet Aggregation; Platelet Count; Quinacrine; Serotonin; Thionucleotides; Thrombin | 1984 |
Assessment of a role for phospholipase A2 and arachidonic acid metabolism in human lymphocyte natural cytotoxicity.
Topics: Acetophenones; Arachidonic Acid; Arachidonic Acids; Binding, Competitive; Cyclooxygenase Inhibitors; Cytotoxicity, Immunologic; Dexamethasone; Humans; Hydrocortisone; Killer Cells, Natural; Kinetics; Lipoxygenase Inhibitors; Phospholipases; Phospholipases A; Phospholipases A2; Quinacrine | 1984 |
Synthesis of prostaglandin F by cultured human endometrial cells.
Topics: Arachidonic Acid; Arachidonic Acids; Bradykinin; Cells, Cultured; Dose-Response Relationship, Drug; Endometrium; Estradiol; Female; Histamine; Humans; Hydrocortisone; In Vitro Techniques; Prostaglandins F; Quinacrine; Tetradecanoylphorbol Acetate | 1984 |
The release and metabolism of [3H]arachidonic acid from guinea pig perfused lungs in vitro: a simple method for the study of the action of drugs on the release and metabolism of arachidonic acid.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Bradykinin; Guinea Pigs; In Vitro Techniques; Indomethacin; Lung; Quinacrine | 1981 |
Differential effects of calmodulin antagonists on phospholipases A2 and C in thrombin-stimulated platelets.
Topics: Arachidonic Acid; Arachidonic Acids; Blood Platelets; Calcium-Binding Proteins; Calmodulin; Chlorpromazine; Dibucaine; Fluphenazine; Humans; Kinetics; Phospholipases; Phospholipases A; Phospholipids; Platelet Aggregation; Quinacrine; Thrombin; Trifluoperazine; Type C Phospholipases | 1981 |
Direct interaction of mepacrine with erythrocyte and platelet membrane phospholipid.
Topics: Arachidonic Acid; Arachidonic Acids; Blood Platelets; Cell Membrane; Erythrocyte Membrane; Erythrocytes; Humans; Kinetics; Membrane Lipids; Phospholipases; Phospholipids; Quinacrine; Thrombin | 1982 |
The importance of the production of phosphatidic acid for the release of arachidonic acid in stimulated platelets.
Topics: Arachidonic Acid; Arachidonic Acids; Blood Platelets; Calcimycin; Humans; In Vitro Techniques; Phosphatidic Acids; Phospholipases A; Phospholipases A2; Quinacrine; Stimulation, Chemical; Thrombin | 1981 |
The effect of inhibitors of arachidonic acid metabolism on drug-induced contractions in isolated tracheal smooth muscle of the pig.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Acetylcholine; Animals; Arachidonic Acid; Arachidonic Acids; Dexamethasone; In Vitro Techniques; Indomethacin; Muscle Contraction; Muscle, Smooth; Potassium; Prostaglandins E; Quinacrine; Receptors, Histamine; Sodium Salicylate; Swine; Trachea | 1982 |
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced epidermal ornithine decarboxylase activity by phospholipase A2 inhibitors and lipoxygenase inhibitor.
Topics: Animals; Antioxidants; Arachidonic Acid; Arachidonic Acids; Carboxy-Lyases; Catechols; Dinoprostone; Female; Indomethacin; Lipoxygenase Inhibitors; Masoprocol; Mice; Ornithine Decarboxylase; Phorbols; Phospholipases; Phospholipases A; Phospholipases A2; Prostaglandins E; Quinacrine; Skin; Tetracaine; Tetradecanoylphorbol Acetate | 1982 |
The effects of mepacrine and p-bromophenacyl bromide on arachidonic acid release in human platelets.
Topics: Acetophenones; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Dose-Response Relationship, Drug; Humans; Quinacrine; Serotonin; Thrombin; Type C Phospholipases | 1982 |
Studies on the incorporation of [1-14C]arachidonic acid into glycerolipids and its conversion into prostaglandins by rabbit iris. Effects of anti-inflammatory drugs and phospholipase A2 inhibitors.
Topics: Acetophenones; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Aspirin; Diglycerides; Female; Indomethacin; Iris; Lipid Metabolism; Male; Microsomes; Muscle, Smooth; Phospholipases; Phospholipases A; Phospholipases A2; Phospholipids; Prostaglandins; Quinacrine; Rabbits; Triglycerides | 1982 |
Effects of lipid peroxidation, Ca2+ and adrenalin on the release of fatty acids from rabbit kidney cortex slices.
Topics: Adipose Tissue; Animals; Arachidonic Acid; Arachidonic Acids; Ascorbic Acid; Calcium; Epinephrine; Fatty Acids; In Vitro Techniques; Kidney Cortex; Kidney Medulla; Kinetics; Lipid Peroxides; Liver; Quinacrine; Rabbits; Triglycerides | 1982 |
Effect of calmodulin antagonists on lysosomal enzyme secretion and phospholipid metabolism in guinea-pig macrophages.
Topics: Acetylglucosaminidase; Animals; Arachidonic Acid; Arachidonic Acids; Calcium-Binding Proteins; Calmodulin; Dibucaine; Female; Guinea Pigs; Hexosaminidases; In Vitro Techniques; Lysosomes; Macrophages; Phospholipids; Quinacrine; Trifluoperazine; Triglycerides | 1982 |
Ca(2+)-independent fusion of secretory granules with phospholipase A2-treated plasma membranes in vitro.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Albumins; Amylases; Animals; Arachidonic Acid; Benzoquinones; Calcium; Cell Membrane; Cytoplasmic Granules; Egtazic Acid; Exocytosis; Fatty Acids; Indomethacin; Lipoxygenase Inhibitors; Lysophosphatidylcholines; Male; Membrane Fusion; Microscopy, Electron; Parotid Gland; Phospholipases A; Phospholipases A2; Quinacrine; Rats; Rats, Wistar | 1995 |
Exposure to gp120 of HIV-1 induces an increased release of arachidonic acid in rat primary neuronal cell culture followed by NMDA receptor-mediated neurotoxicity.
Topics: Animals; Arachidonic Acid; Cell Death; Cells, Cultured; DNA Damage; HIV Envelope Protein gp120; HIV-1; Neurons; Neurotoxins; Quinacrine; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1995 |
Increase of bradykinin-stimulated arachidonic acid release in a delta F508 cystic fibrosis epithelial cell line.
Topics: Arachidonic Acid; Bradykinin; Cell Line; Cholera Toxin; Culture Media; Cyclic AMP; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Epithelium; Ion Channels; Membrane Proteins; Mutation; Phospholipids; Quinacrine; Skin; Trachea; Virulence Factors, Bordetella | 1993 |
NMDA-dependent superoxide production and neurotoxicity.
Topics: Amino Acid Oxidoreductases; Animals; Arachidonic Acid; Arginine; Calcium Channels; Cell Death; Cells, Cultured; Cerebral Cortex; Computer Simulation; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Mice; Nitric Oxide Synthase; Nitroarginine; Quinacrine; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Superoxide Dismutase; Superoxides; Xanthine; Xanthine Oxidase; Xanthines | 1993 |
Growth hormone signaling leading to CYP2C12 gene expression in rat hepatocytes involves phospholipase A2.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Arachidonic Acid; Aryl Hydrocarbon Hydroxylases; Benzoquinones; Calcimycin; Calcium-Calmodulin-Dependent Protein Kinases; Cytochrome P-450 Enzyme System; Diglycerides; Enzyme Activation; Gene Expression Regulation; Growth Hormone; Insulin-Like Growth Factor I; Ketoconazole; Lactams, Macrocyclic; Liver; Phospholipases A; Phospholipases A2; Phospholipids; Phosphorylation; Proadifen; Protein-Tyrosine Kinases; Quinacrine; Quinones; Rats; Rats, Sprague-Dawley; Rifabutin; RNA, Messenger; Signal Transduction; Steroid Hydroxylases; Verapamil | 1995 |
Endothelium-dependent contraction induced by acetylcholine in isolated rat renal arteries.
Topics: Acetylcholine; Animals; Arachidonic Acid; Arginine; Aspirin; Atropine; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Endothelium, Vascular; Fatty Acids, Monounsaturated; Fatty Acids, Unsaturated; Hexamethonium; Hydrazines; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nitroarginine; Phospholipases A; Quinacrine; Rats; Rats, Inbred WKY; Receptors, Prostaglandin; Renal Artery; Terpenes; Thromboxane A2; Thromboxane-A Synthase | 1995 |
Effects of organometals on cellular signaling. I. Influence of metabolic inhibitors on metal-induced arachidonic acid liberation.
Topics: Arachidonic Acid; Calcium; Cell Communication; Culture Media; Egtazic Acid; Homeostasis; Humans; Organometallic Compounds; Pertussis Toxin; Phospholipases A; Phospholipases A2; Quinacrine; Tumor Cells, Cultured; Verapamil; Virulence Factors, Bordetella | 1994 |
Modulation of glutamate and aspartate release from slices of hippocampal area CA1 by inhibitors of arachidonic acid metabolism.
Topics: Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Arginine; Aspartic Acid; Female; Flavanones; Flavonoids; gamma-Aminobutyric Acid; Glutamates; Hippocampus; In Vitro Techniques; Indoles; Indomethacin; Masoprocol; omega-N-Methylarginine; Platelet Activating Factor; Potassium; Prostaglandin-Endoperoxide Synthases; Quinacrine; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Taurine | 1995 |
Sulfur mustard-induced increase in intracellular free calcium level and arachidonic acid release from cell membrane.
Topics: Animals; Arachidonic Acid; Calcium; Cell Membrane; Cell Survival; Glioma; Glutathione; Hybrid Cells; Intracellular Fluid; Kinetics; Mice; Mustard Gas; Neuroblastoma; Quinacrine; Rats; Tritium; Tumor Cells, Cultured | 1995 |
Hypotonically activated chloride current in HSG cells.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; Actins; Arachidonic Acid; Calcium; Cell Line; Cell Membrane; Chloride Channels; Cytochalasin D; Cytoskeleton; Dose-Response Relationship, Drug; Egtazic Acid; Guanosine Triphosphate; Humans; Hypotonic Solutions; Nitrobenzoates; Patch-Clamp Techniques; Potassium Channels; Quinacrine; Submandibular Gland | 1994 |
Display of the characteristics of endothelium-derived hyperpolarizing factor by a cytochrome P450-derived arachidonic acid metabolite in the coronary microcirculation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arachidonic Acid; Arginine; Biological Factors; Bradykinin; Calcium Channel Blockers; Capillaries; Coronary Vessels; Cytochrome P-450 Enzyme System; Diclofenac; Epoprostenol; Female; In Vitro Techniques; Male; Nitric Oxide; Nitroarginine; Nitroprusside; Prostaglandin Endoperoxides, Synthetic; Quinacrine; Rats; Rats, Wistar; Thromboxane A2; Vasoconstrictor Agents; Vasodilation | 1994 |
On the role of arachidonic acid in M-current modulation by muscarine in bullfrog sympathetic neurons.
Topics: Acetophenones; Animals; Arachidonic Acid; Dose-Response Relationship, Drug; Ganglia, Sympathetic; Gonadotropin-Releasing Hormone; In Vitro Techniques; Kinetics; Masoprocol; Membrane Potentials; Muscarine; Neurons; Phospholipases A; Phospholipases A2; Potassium Channels; Quinacrine; Rana catesbeiana | 1994 |
NMDA receptors mediate anoxia/aglycemia-induced release of eicosanoids in immature rat hippocampal slices: utility of an in vitro "ischemic" superfusion model with temporary arrest of medium flow.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Brain Ischemia; Calcium; Culture Techniques; Dizocilpine Maleate; Eicosanoids; Hippocampus; Hypoxia; N-Methylaspartate; Quinacrine; Radioimmunoassay; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Thromboxane B2 | 1994 |
Evidence for a role of phospholipase A2 in the mechanism of LHRH priming in rat anterior pituitary tissue.
Topics: Acetophenones; Aminobenzoates; Animals; Arachidonic Acid; Aristolochic Acids; Calcium; Chlorobenzoates; Cinnamates; Cycloheximide; Female; Gonadotropin-Releasing Hormone; In Vitro Techniques; Luteinizing Hormone; ortho-Aminobenzoates; Phenanthrenes; Phenothiazines; Phospholipases A; Phospholipases A2; Pituitary Gland, Anterior; Proestrus; Quinacrine; Rats; Rats, Wistar | 1994 |
Agonist-induced desensitization and loss of high-affinity binding sites of stably expressed human 5-HT1A receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclase Inhibitors; Arachidonic Acid; Binding Sites; Calcium; Colforsin; Enzyme Activation; HeLa Cells; Humans; Ligands; Phosphatidylinositols; Phospholipases A; Phospholipases A2; Phosphorylation; Protein Kinase C; Quinacrine; Receptors, Serotonin; Serotonin; Tetradecanoylphorbol Acetate | 1994 |
Arachidonic acid metabolites in bFGF-, PDGF-, and serum-stimulated vascular cell growth.
Topics: Animals; Arachidonic Acid; Cattle; Cell Division; Cells, Cultured; Cyclooxygenase Inhibitors; Endothelium, Vascular; Fibroblast Growth Factor 2; Flavanones; Flavonoids; In Vitro Techniques; Lipoxygenase Inhibitors; Masoprocol; Muscle, Smooth, Vascular; Phospholipase D; Phospholipases A; Phospholipases A2; Platelet-Derived Growth Factor; Propranolol; Quinacrine; Signal Transduction | 1994 |
Light-evoked arachidonic acid release in the retina: illuminance/duration dependence and the effects of quinacrine, mellitin and lithium. Light-evoked arachidonic acid release.
Topics: Administration, Oral; Animals; Arachidonic Acid; Dark Adaptation; Lithium; Male; Melitten; Membrane Lipids; Phospholipases A; Phospholipases A2; Photic Stimulation; Quinacrine; Rats; Retina; Rhodopsin; Rod Cell Outer Segment; Sensory Thresholds | 1994 |
Differential involvement of phospholipase A2 in phorbol ester-induced luteinizing hormone and growth hormone release from rat anterior pituitary tissue.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Aminobenzoates; Animals; Arachidonic Acid; Aristolochic Acids; Chlorobenzoates; Cinnamates; Cyclohexanones; Cycloheximide; Enzyme Activation; Female; Growth Hormone; Indoles; Ionomycin; Isoquinolines; Luteinizing Hormone; Melitten; ortho-Aminobenzoates; Phenanthrenes; Phenothiazines; Phorbol 12,13-Dibutyrate; Phospholipases A; Phospholipases A2; Piperazines; Pituitary Gland, Anterior; Proestrus; Protein Kinase C; Quinacrine; Rats; Rats, Wistar; Signal Transduction; Staurosporine | 1993 |
The mechanism of bradykinin-induced arachidonic acid release in osteoblast-like MC3T3-E1 cells phospholipase A2 activation by bradykinin and its regulation by protein kinase C and calcium.
Topics: 3T3 Cells; Alkaloids; Animals; Arachidonic Acid; Bradykinin; Calcium; Cells, Cultured; Down-Regulation; Mice; Osteoblasts; Phospholipases A; Phospholipases A2; Protein Kinase C; Quinacrine; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
The requirement for phospholipase A2 for activation of the assembled NADPH oxidase in human neutrophils.
Topics: Acetophenones; Alkaloids; Arachidonic Acid; Biological Transport; Cell Membrane; Enzyme Activation; Humans; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Opsonin Proteins; Phospholipases A; Phospholipases A2; Phosphorylation; Protein Kinase C; Quinacrine; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate; Tritium; Zymosan | 1994 |
Stimulation of arachidonic-acid release from Swiss 3T3 cells by recombinant basic fibroblast growth factor: independence from phosphoinositide turnover.
Topics: 3T3 Cells; Animals; Arachidonic Acid; Dinoprostone; DNA; Fibroblast Growth Factor 2; Mice; Neomycin; Phosphatidylinositols; Quinacrine; Recombinant Proteins; Time Factors; Tritium | 1994 |
Hydrogen peroxide stimulates transcription of c-jun in vascular smooth muscle cells: role of arachidonic acid.
Topics: Animals; Arachidonic Acid; Cells, Cultured; Down-Regulation; Glyceraldehyde-3-Phosphate Dehydrogenases; Hydrogen Peroxide; Male; Masoprocol; Muscle, Smooth, Vascular; Peptide Fragments; Phospholipases A; Phospholipases A2; Protein Kinase C; Proto-Oncogene Proteins c-jun; Quinacrine; Rats; Rats, Sprague-Dawley; RNA, Messenger; Transcription, Genetic | 1993 |
Regulation of human eosinophil degranulation and activation by endogenous phospholipase A2.
Topics: Acetophenones; Arachidonic Acid; Cell Separation; Centrifugation, Density Gradient; Cytochalasin B; Dose-Response Relationship, Drug; Eosinophil Peroxidase; Eosinophils; Homeostasis; In Vitro Techniques; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Peroxidases; Phospholipases A; Phospholipases A2; Quinacrine; SRS-A; Superoxides | 1993 |
Arachidonic acid, a growth signal in murine P815 mastocytoma cells.
Topics: Animals; Arachidonic Acid; Cell Division; Cells, Cultured; Chromatography, High Pressure Liquid; Culture Media, Serum-Free; Mast-Cell Sarcoma; Mice; Phosphatidylinositols; Phosphorylation; Quinacrine; Terpenes | 1993 |
Eicosanoid production by mouse peritoneal macrophages during Toxoplasma gondii penetration: role of parasite and host cell phospholipases.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Animals; Arachidonic Acid; Calcium; Cyclooxygenase Inhibitors; Eicosanoids; Female; Indomethacin; Isoquinolines; Lipoxygenase; Macrophages; Mice; Peritoneal Cavity; Phospholipases; Piperazines; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Quinacrine; Toxoplasma; Toxoplasmosis, Animal | 1993 |
Hydrogen peroxide-induced c-fos expression is mediated by arachidonic acid release: role of protein kinase C.
Topics: Animals; Arachidonic Acid; Blotting, Northern; Cells, Cultured; Gene Expression; Hydrogen Peroxide; Indomethacin; Male; Masoprocol; Protein Kinase C; Proto-Oncogene Proteins c-fos; Quinacrine; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1993 |
Inhibitors of the arachidonic acid metabolism attenuate the thyroliberin (TRH) stimulated prolactin production without modifying the production of inositolphosphates in GH4C1 pituitary cells.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Arachidonic Acid; Inositol Phosphates; Lipoprotein Lipase; Lipoxygenase Inhibitors; Phospholipases A; Phospholipases A2; Pituitary Neoplasms; Prolactin; Pyrazoles; Pyrazolones; Quinacrine; Rats; Thyrotropin-Releasing Hormone; Tumor Cells, Cultured | 1993 |
Stimulation of prostaglandin synthesis by human endothelial cells exposed to hypoxia.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Arachidonic Acid; Calcium; Carbon Radioisotopes; Cell Hypoxia; Endothelium, Vascular; Humans; Indomethacin; Kinetics; Oxygen; Phospholipases A; Phospholipases A2; Prostaglandins; Quinacrine; Stearic Acids; Tritium; Umbilical Veins; Verapamil | 1993 |
Botulinum toxin inhibits arachidonic acid release associated with acetylcholine release from PC12 cells.
Topics: Acetophenones; Acetylcholine; Animals; Arachidonic Acid; Botulinum Toxins; Cell Differentiation; Dose-Response Relationship, Drug; Ethacrynic Acid; Indomethacin; Kinetics; Masoprocol; Melitten; Models, Biological; Nerve Growth Factors; PC12 Cells; Phospholipases A; Phospholipases A2; Potassium; Protein Kinase C; Quinacrine; Terpenes | 1993 |
The regulation of neutrophil phospholipase A2 by granulocyte-macrophage colony-stimulating factor and its role in priming superoxide production.
Topics: Arachidonic Acid; Calcimycin; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Phospholipases A; Phospholipases A2; Quinacrine; Superoxides | 1996 |
Mitogen-activated protein kinase activation in hepatocyte growth factor-stimulated rat hepatocytes: involvement of protein tyrosine kinase and protein kinase C.
Topics: Animals; Arachidonic Acid; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; DNA; Enzyme Activation; Enzyme Inhibitors; Genistein; Hepatocyte Growth Factor; Isoflavones; Liver; Male; Mitogen-Activated Protein Kinase Kinases; Phospholipases A; Phospholipases A2; Prostaglandins; Protein Kinase C; Protein Kinases; Protein-Tyrosine Kinases; Quinacrine; ras Proteins; Rats; Rats, Wistar; Tetradecanoylphorbol Acetate | 1996 |
Activation of serotonergic 5-HT1A receptor reduces Ca(2+)- and glutamatergic receptor-evoked arachidonic acid and No/cGMP release in adult hippocampus.
Topics: 2-Amino-5-phosphonovalerate; Animals; Arachidonic Acid; Buspirone; Calcium; Cyclic GMP; Enzyme Inhibitors; Hippocampus; In Vitro Techniques; Ketanserin; N-Methylaspartate; Neurons; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Quinacrine; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Synaptosomes | 1996 |
Regulation of tight junction resistance in T84 monolayers by elevation in intracellular Ca2+: a protein kinase C effect.
Topics: Arachidonic Acid; Calcimycin; Calcium; Cell Membrane Permeability; Chelating Agents; Egtazic Acid; Humans; Ionophores; Mannitol; Phospholipases; Protein Kinase C; Quinacrine; Tetradecanoylphorbol Acetate; Tight Junctions; Tumor Cells, Cultured | 1996 |
Phospholipase A2 is involved in the mechanism of activation of neutrophils by polychlorinated biphenyls.
Topics: Animals; Arachidonic Acid; Aroclors; Aspirin; Cyclooxygenase Inhibitors; Hydroxyurea; In Vitro Techniques; Lipoxygenase Inhibitors; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Phospholipases A; Phospholipases A2; Polychlorinated Biphenyls; Quinacrine; Rats; Superoxides; Terpenes; Tetradecanoylphorbol Acetate | 1996 |
Ca(2+)-independent fusion of synaptic vesicles with phospholipase A2-treated presynaptic membranes in vitro.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Acetylcholine; Albumins; Animals; Arachidonic Acid; Benzoquinones; Brain; Calcium; Egtazic Acid; Exocytosis; In Vitro Techniques; Indomethacin; Male; Membrane Fusion; Neurotransmitter Agents; Phospholipases A; Phospholipases A2; Quinacrine; Rats; Rats, Wistar; Swine; Synaptic Membranes; Synaptic Vesicles | 1996 |
Role of intracellular signalling pathways in hydrogen peroxide-induced injury to rat glomerular mesangial cells.
Topics: Animals; Arachidonic Acid; Calcium; Cells, Cultured; Hydrogen Peroxide; Kidney Glomerulus; Quinacrine; Rats; Rats, Wistar; Signal Transduction; Time Factors | 1995 |
Caerulein-stimulated arachidonic acid release in rat pancreatic acini: a diacylglycerol lipase affair.
Topics: Androstadienes; Animals; Arachidonic Acid; Aristolochic Acids; Carbachol; Cells, Cultured; Ceruletide; Cyclohexanones; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Estrenes; Kinetics; Lipoprotein Lipase; Lipoxygenase Inhibitors; Male; Pancreas; Phenanthrenes; Phospholipase D; Phospholipases A; Phospholipases A2; Pyrrolidinones; Quinacrine; Rats; Rats, Sprague-Dawley; Wortmannin | 1996 |
Possible mechanism of increase in gastric mucosal PGE2 and PGI2 generation induced by ecabet sodium, a novel gastroprotective agent.
Topics: Abietanes; Animals; Anti-Ulcer Agents; Arachidonic Acid; Calcium; Dinoprostone; Diterpenes; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epoprostenol; Gastric Mucosa; Hydroxyprostaglandin Dehydrogenases; In Vitro Techniques; Male; Membrane Fluidity; Phospholipases A; Phospholipases A2; Quinacrine; Rats; Rats, Sprague-Dawley; Thromboxane A2 | 1997 |
Characterization of melittin effects in synaptosomes.
Topics: Animals; Arachidonic Acid; Brain; Calcium; gamma-Aminobutyric Acid; Indomethacin; L-Lactate Dehydrogenase; Male; Masoprocol; Melitten; Mice; Microscopy, Electron; Quinacrine; Synaptosomes; Tritium | 1997 |
Conductive Na+ transport in fetal lung alveolar apical membrane vesicles is regulated by fatty acids and G proteins.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Amiloride; Animals; Arachidonic Acid; Biological Transport; Cell Membrane; Enzyme Inhibitors; Fatty Acids; Fetus; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Guinea Pigs; Indomethacin; Masoprocol; Pulmonary Alveoli; Quinacrine; Sodium; Sodium Channels; Thionucleotides | 1997 |
PLA2 activity in Tetrahymena pyriformis. Effects of inhibitors and stimulators.
Topics: Acetophenones; Aluminum Compounds; Animals; Arachidonic Acid; Calcium; Enzyme Activation; Enzyme Inhibitors; Fluorides; Hydrogen Peroxide; Inositol; Lithium Chloride; Melitten; Phorbol 12,13-Dibutyrate; Phosphatidylinositols; Phospholipases A; Phospholipases A2; Phospholipids; Protein-Tyrosine Kinases; Quinacrine; Signal Transduction; Sodium Fluoride; Tetrahymena pyriformis; Vanadates | 1997 |
Increased PLA2 activity is not related to increase GLUT1 expression in L6 myotubes under hypoxic conditions.
Topics: Acetophenones; Animals; Arachidonic Acid; Biological Transport; Cell Hypoxia; Cell Line; Cyclooxygenase Inhibitors; Deoxyglucose; Glucose; Glucose Transporter Type 1; Glucose Transporter Type 4; Insulin; Membrane Proteins; Monosaccharide Transport Proteins; Muscle Proteins; Muscle, Skeletal; Phospholipases A; Phospholipases A2; Prostaglandins; Quinacrine; Rats; Signal Transduction | 1997 |
Endogenous arachidonic acid release and pancreatic amylase secretion.
Topics: Amylases; Animals; Arachidonic Acid; Aristolochic Acids; Carbachol; Cyclohexanones; Enzyme Inhibitors; In Vitro Techniques; Lipoprotein Lipase; Male; Melitten; Pancreas; Phenanthrenes; Phospholipases A; Phospholipases A2; Quinacrine; Rats; Rats, Sprague-Dawley | 1997 |
Phospholipases and arachidonic acid contribute independently to sensory transduction and associative neuronal facilitation in Hermissenda type B photoreceptors.
Topics: Acetophenones; Animals; Arachidonic Acid; Association Learning; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Indomethacin; Lipoxygenase Inhibitors; Masoprocol; Mollusca; Neurons; Phospholipases; Photoreceptor Cells, Invertebrate; Quinacrine; Sensation; Signal Transduction | 1997 |
Evidence against the involvement of cytochrome P450 metabolites in endothelium-dependent hyperpolarization of the rat main mesenteric artery.
Topics: Animals; Arachidonic Acid; Biological Factors; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Electric Stimulation; Electrophysiology; Endothelium, Vascular; Enzyme Inhibitors; In Vitro Techniques; Indomethacin; Kinetics; Membrane Potentials; Mesenteric Arteries; Phospholipases A; Quinacrine; Rats; Rats, Wistar | 1997 |
Mechanism of thrombin-induced arachidonic acid release in osteoblast-like cells.
Topics: 3T3 Cells; Animals; Arachidonic Acid; Cyclohexanones; Dinoprostone; Enzyme Inhibitors; Estrenes; Lipoprotein Lipase; Mice; Osteoblasts; Phosphatidate Phosphatase; Phospholipases A; Phospholipases A2; Propranolol; Pyrrolidinones; Quinacrine; Thrombin; Type C Phospholipases | 1997 |
Cross talk between substance P and melittin-activated cellular signaling pathways in rat lactotroph-enriched cell cultures.
Topics: Animals; Arachidonic Acid; Aristolochic Acids; Cells, Cultured; Enzyme Inhibitors; Female; Inositol 1,4,5-Trisphosphate; Isoenzymes; Male; Melitten; Phenanthrenes; Phospholipases A; Phospholipases A2; Pituitary Gland, Anterior; Prolactin; Protein Kinase C; Quinacrine; Rats; Rats, Wistar; Signal Transduction; Substance P; Tetradecanoylphorbol Acetate; Tritium | 1997 |
Endothelium-derived hyperpolarizing factor: characterization as a cytochrome P450 1A-linked metabolite of arachidonic acid in perfused rat mesenteric prearteriolar bed.
Topics: Acetylcholine; Animals; Arachidonic Acid; Biological Factors; Cyclooxygenase Inhibitors; Cytochrome P-450 CYP1A1; Enzyme Inhibitors; Histamine; Indomethacin; Male; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Perfusion; Phospholipases A; Phospholipases A2; Quinacrine; Rats; Rats, Sprague-Dawley; Vasodilation | 1997 |
Muscarinic autoinhibition and modulatory role of protein kinase C in acetylcholine release from the myenteric plexus of guinea pig ileum.
Topics: Acetylcholine; Animals; Arachidonic Acid; Atropine; Benzoquinones; Chromatography, High Pressure Liquid; Electric Stimulation; Estrenes; Guinea Pigs; Ileum; In Vitro Techniques; Lipoxygenase Inhibitors; Male; Melitten; Muscle, Smooth; Myenteric Plexus; Naphthalenes; Phorbol 12,13-Dibutyrate; Phospholipases A; Phospholipases A2; Protein Kinase C; Pyrrolidinones; Quinacrine; Receptors, Muscarinic; Staurosporine; Type C Phospholipases | 1997 |
Stimulatory action of endothelin-1 on rat Leydig cells: involvement of endothelin-A subtype receptor and phospholipase A2-arachidonate metabolism system.
Topics: Animals; Arachidonic Acid; Calcium; Endothelin Receptor Antagonists; Endothelin-1; Enzyme Inhibitors; Gonadotropin-Releasing Hormone; Humans; Leydig Cells; Lipoxygenase Inhibitors; Male; Masoprocol; Oligopeptides; Peptides, Cyclic; Phosphatidylinositols; Phospholipases A; Phospholipases A2; Piperidines; Quinacrine; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptors, Endothelin; Testosterone | 1997 |
Arachidonic acid and its metabolites are involved in the expression of morphine dependence in guinea-pig isolated ileum.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Cyclooxygenase Inhibitors; Guinea Pigs; Ileum; In Vitro Techniques; Lipoxygenase Inhibitors; Male; Masoprocol; Meloxicam; Morphine; Muscle Contraction; Naloxone; Narcotic Antagonists; Phospholipases A; Phospholipases A2; Quinacrine; Substance-Related Disorders; Thiazines; Thiazoles; Tolmetin | 1997 |
Regulation of phosphatidylethanolamine degradation by enzyme(s) of subcellular fractions from cerebral cortex.
Topics: Animals; Arachidonic Acid; Calcium; Cerebral Cortex; Diglycerides; Egtazic Acid; Enzyme Inhibitors; Hydrogen-Ion Concentration; Hydrolysis; Neomycin; Phosphatidylethanolamines; Phospholipases A; Phospholipases A2; Quinacrine; Rats; Rats, Wistar; Subcellular Fractions; Synaptic Membranes; Type C Phospholipases | 1997 |
Modulation of neuronal mitochondrial membrane potential by the NMDA receptor: role of arachidonic acid.
Topics: 2-Amino-5-phosphonovalerate; Anesthetics, Local; Animals; Arachidonic Acid; Biomarkers; Cells, Cultured; Cerebellum; Dibucaine; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Flow Cytometry; Fluorescent Dyes; Glycine; Intracellular Membranes; Kynurenic Acid; Membrane Potentials; Mitochondria; N-Methylaspartate; Piperidines; Quinacrine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Rhodamine 123; Rhodamines; Sulfonamides | 1997 |
Thrombin activates a membrane-associated calcium-independent PLA2 in ventricular myocytes.
Topics: Animals; Arachidonic Acid; Calcium; Cell Membrane; Dibucaine; Enzyme Activation; Enzyme Inhibitors; Female; Heart Ventricles; In Vitro Techniques; Myocardium; Naphthalenes; Peptide Fragments; Phospholipases A; Phospholipases A2; Pyrones; Quinacrine; Rabbits; Receptors, Thrombin; Thrombin | 1998 |
Arachidonic acid mediates angiotensin II effects on p21ras in renal proximal tubular cells via the tyrosine kinase-Shc-Grb2-Sos pathway.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Angiotensin II; Animals; Arachidonic Acid; Cells, Cultured; Enzyme Inhibitors; GRB2 Adaptor Protein; Guanine Nucleotide Exchange Factors; Guanosine Diphosphate; Guanosine Triphosphate; Imidazoles; Kidney Tubules, Proximal; Phospholipases A; Phospholipases A2; Phosphorylation; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins p21(ras); Pyridines; Quinacrine; Rabbits; ras Guanine Nucleotide Exchange Factors; Shc Signaling Adaptor Proteins | 1998 |
Coexpression of phospholipase A2 isoforms in rat striatal astrocytes.
Topics: Animals; Arachidonic Acid; Astrocytes; Calcimycin; Corpus Striatum; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Ionophores; Isoenzymes; Nerve Tissue Proteins; Phospholipases A; Phospholipases A2; Polymerase Chain Reaction; Protein Kinase C; Quinacrine; Rats; RNA, Messenger; Tetradecanoylphorbol Acetate | 1998 |
Role of arachidonic acid and its metabolites in the priming of NADPH oxidase in human polymorphonuclear leukocytes by peritoneal dialysis effluent.
Topics: Anti-Inflammatory Agents; Arachidonic Acid; Cyclooxygenase Inhibitors; Dialysis Solutions; Enzyme Activation; Enzyme Inhibitors; Homosteroids; Humans; Leukocytes, Mononuclear; Leukotriene B4; NADPH Oxidases; Peritoneal Dialysis, Continuous Ambulatory; Phospholipases A; Phospholipases A2; Quinacrine; Sesterterpenes; Superoxides; Terpenes | 1998 |
Effect of propofol on arachidonate cascade by vasopressin in aortic smooth muscle cells: inhibition of PGI2 synthesis.
Topics: Anesthetics, Intravenous; Animals; Aorta, Thoracic; Arachidonic Acid; Arginine Vasopressin; Cells, Cultured; Choline; Enzyme Inhibitors; Epoprostenol; Estrenes; Humans; Inositol Phosphates; Muscle, Smooth, Vascular; Phospholipases; Propofol; Propranolol; Pyrrolidinones; Quinacrine; Rats; Vasoconstrictor Agents; Vasopressins | 1999 |
Role of arachidonic acid in the regulation of the NMDA-evoked release of acetylcholine in striatal compartments.
Topics: Acetylcholine; Animals; Arachidonic Acid; Bicuculline; Corpus Striatum; Dopamine; Enzyme Inhibitors; GABA Antagonists; gamma-Aminobutyric Acid; Male; N-Methylaspartate; Phospholipases A; Phospholipases A2; Quinacrine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serum Albumin, Bovine | 1999 |
Contribution of endogenously formed arachidonic acid in the presynaptic facilitatory effects of NMDA and carbachol on dopamine release in the mouse striatum.
Topics: Animals; Arachidonic Acid; Carbachol; Corpus Striatum; Dopamine; Drug Resistance; Drug Synergism; Enzyme Inhibitors; Magnesium; Male; Mice; N-Methylaspartate; Phospholipases A; Phospholipases A2; Presynaptic Terminals; Quinacrine; Synapses; Tetrodotoxin | 1999 |
Inhibition of phospholipase A2 attenuates functional hyperemia in the hamster cremaster muscle.
Topics: Adenosine; Animals; Arachidonic Acid; Arterioles; Cricetinae; Enzyme Inhibitors; Hyperemia; Male; Mesocricetus; Muscle, Skeletal; Nitroprusside; Phospholipases A; Phospholipases A2; Quinacrine; Vasodilation; Vasodilator Agents | 1999 |
The beta1-integrin cytosolic domain optimizes phospholipase A2-mediated arachidonic acid release required for NIH-3T3 cell spreading.
Topics: 3T3 Cells; Animals; Arachidonic Acid; Cell Movement; Chickens; Cytosol; Enzyme Inhibitors; Integrin beta1; Mice; Phospholipases A; Phospholipases A2; Quinacrine | 1999 |
Protopanaxatriol ginsenosides inhibit glucose uptake in primary cultured rabbit renal proximal tubular cells by arachidonic acid release.
Topics: Animals; Arachidonic Acid; Cells, Cultured; Central Nervous System Agents; Choline; Enzyme Inhibitors; Ginsenosides; Glucose; In Vitro Techniques; Kidney Tubules, Proximal; Kinetics; Male; Panax; Phospholipases A; Phospholipases A2; Plants, Medicinal; Quinacrine; Rabbits; Sapogenins; Saponins; Signal Transduction; Triterpenes | 1999 |
The role of arachidonic acid on LH-stimulated steroidogenesis and steroidogenic acute regulatory protein accumulation in MA-10 mouse Leydig tumor cells.
Topics: Animals; Arachidonic Acid; Bucladesine; Enzyme Inhibitors; Leydig Cell Tumor; Luteinizing Hormone; Mice; Phospholipases A; Phosphoproteins; Progesterone; Quinacrine; Tumor Cells, Cultured | 1999 |
Role of phospholipase A2 in the cytotoxic effects of oxalate in cultured renal epithelial cells.
Topics: Anesthetics, Local; Animals; Arachidonic Acid; Arachidonic Acids; Biological Transport; Cell Line; Cyclohexanones; Dibucaine; Diglycerides; Dogs; Enzyme Inhibitors; Epithelial Cells; Free Radicals; Kidney Tubules, Distal; Oleic Acid; Oxalates; Phospholipases A; Phospholipases A2; Protease Inhibitors; Quinacrine; Tritium | 1999 |
Role of arachidonic acid in leukotriene B(4)-induced guinea-pig eosinophil homotypic aggregation.
Topics: Animals; Arachidonic Acid; Calcium; Cell Aggregation; Dose-Response Relationship, Drug; Eosinophils; Female; Guinea Pigs; Leukotriene Antagonists; Leukotriene B4; Lipoxygenase Inhibitors; Male; Phospholipases A; Pyrans; Quinacrine; Quinolones; Tetradecanoylphorbol Acetate; Tetrazoles | 1999 |
Phospholipase A2 is involved in chemotaxis of human leukocytes.
Topics: Adult; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Chemotaxis, Leukocyte; Dinoprostone; Enzyme Inhibitors; Humans; In Vitro Techniques; Isoenzymes; Leukocytes; Leukotriene B4; Male; Middle Aged; N-Formylmethionine Leucyl-Phenylalanine; Phospholipase C beta; Phospholipases A; Phospholipases A2; Prostaglandin-Endoperoxide Synthases; Quinacrine; Sodium Fluoride; Spiro Compounds; Terpenes; Type C Phospholipases | 1999 |
Lysophosphatidylcholine and arachidonic acid are required in the cytotoxic response of human natural killer cells to tumor target cells.
Topics: Acetophenones; Arachidonic Acid; Cytotoxicity, Immunologic; Enzyme Inhibitors; Humans; K562 Cells; Killer Cells, Natural; Leukotrienes; Linoleic Acid; Lipid Peroxides; Lysophosphatidylcholines; Phospholipases A; Quinacrine | 1999 |
High glucose-induced inhibition of alpha-methyl-D-glucopyranoside uptake is mediated by protein kinase C-dependent activation of arachidonic acid release in primary cultured rabbit renal proximal tubule cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Biological Transport; Cells, Cultured; Choline; Enzyme Inhibitors; Glucose; Kidney Tubules, Proximal; Kinetics; Male; Mannitol; Methylglucosides; Phlorhizin; Protein Kinase C; Quinacrine; Rabbits | 2000 |
Brain phospholipase A(2)-arachidonic acid cascade is involved in the activation of central sympatho-adrenomedullary outflow in rats.
Topics: Animals; Arachidonic Acid; Brain; Enzyme Inhibitors; Epinephrine; Indomethacin; Male; Melitten; Norepinephrine; Phospholipases A; Quinacrine; Rats; Rats, Wistar; Signal Transduction | 2000 |
Cellular mechanisms involved in iso-osmotic high K+ solutions-induced contraction of the estrogen-primed rat myometrium.
Topics: Animals; Arachidonic Acid; Calcium; Calcium Channels; Enzyme Inhibitors; Estrogens; Female; Muscle Contraction; Myometrium; omega-Conotoxins; Phosphatidylinositols; Potassium Chloride; Quinacrine; Rats; Uterine Contraction; Uterus | 2000 |
Phospholipase A2 mediates immediate early genes in cultured renal epithelial cells: possible role of lysophospholipid.
Topics: Animals; Apoptosis; Arachidonic Acid; Arachidonic Acids; Blotting, Northern; Calcimycin; Cells, Cultured; DNA-Binding Proteins; Dogs; Enzyme Inhibitors; Epithelial Cells; Gene Expression Regulation, Enzymologic; Genes, Immediate-Early; Ionophores; Kidney; Kidney Calculi; Lysophospholipids; Oxalates; Oxidative Stress; Phospholipases A; Phospholipases A2; Proto-Oncogene Proteins c-jun; Proto-Oncogene Proteins c-myc; Quinacrine; RNA, Messenger; Transcription Factors; Tritium | 2000 |
Mitogenic signal of epidermal growth factor in chick embryo hepatocytes: role of PKCalpha.
Topics: Animals; Arachidonic Acid; Cells, Cultured; Chick Embryo; Diglycerides; Dinoprostone; DNA; Down-Regulation; Enzyme Activation; Epidermal Growth Factor; Gene Expression Regulation, Enzymologic; Hepatocytes; Inositol 1,4,5-Trisphosphate; Isoenzymes; Mitogens; Myristic Acid; Oligonucleotides, Antisense; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-epsilon; Quinacrine; Signal Transduction; Tetradecanoylphorbol Acetate; Thymidine | 2000 |
Calcium-dependent mitochondrial formation of species promoting strand scission of genomic DNA in U937 cells exposed to tert-butylhydroperoxide: the role of arachidonic acid.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Acetophenones; Antimycin A; Arachidonic Acid; Calcium; DNA Damage; Electron Transport; Enzyme Inhibitors; Humans; Melitten; Mitochondria; Phospholipases A; Phospholipases A2; Quinacrine; tert-Butylhydroperoxide; U937 Cells | 2000 |
Involvement of the 5-lipoxygenase pathway in the neurotoxicity of the prion peptide PrP106-126.
Topics: Animals; Annexin A5; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Binding Sites; Caspase 3; Caspases; Cells, Cultured; Cerebellar Cortex; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Memantine; Mice; Mice, Inbred C57BL; Neurons; Neurotoxins; Peptide Fragments; Prion Diseases; Prions; Quinacrine | 2001 |
Cell attachment to extracellular matrices is modulated by pulsed radiation at 820 nm and chemicals that modify the activity of enzymes in the plasma membrane.
Topics: Adenosine Triphosphate; Amiloride; Analysis of Variance; Arachidonic Acid; Cell Adhesion; Cell Membrane; Dimethyl Sulfoxide; Enzyme Activators; Extracellular Matrix; Glucose; HeLa Cells; Humans; In Vitro Techniques; Ouabain; Quinacrine | 2001 |
Arachidonic acid release from rat Leydig cells: the involvement of G protein, phospholipase A2 and regulation of cAMP production.
Topics: Acetophenones; Animals; Arachidonic Acid; Chorionic Gonadotropin; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Leydig Cells; Male; Melitten; Pertussis Toxin; Phospholipases A; Phospholipases A2; Quinacrine; Rats; Rats, Inbred Strains; Stimulation, Chemical; Virulence Factors, Bordetella | 2002 |
alpha 2B-adrenergic receptor activates MAPK via a pathway involving arachidonic acid metabolism, matrix metalloproteinases, and epidermal growth factor receptor transactivation.
Topics: Active Transport, Cell Nucleus; Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Arachidonic Acid; Bacterial Proteins; Brimonidine Tartrate; Butadienes; Cell Line; Cell Nucleus; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; MAP Kinase Signaling System; Matrix Metalloproteinases; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Biological; Nitriles; Pertussis Toxin; Phosphorylation; Protein Binding; Proteins; Quinacrine; Quinazolines; Quinoxalines; Rats; Receptors, Adrenergic, alpha-2; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Swine; Transcriptional Activation; Tyrphostins; Virulence Factors, Bordetella | 2002 |
Pivotal role of superoxides generated in the mitochondrial respiratory chain in peroxynitrite-dependent activation of phospholipase A2.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Arachidonic Acid; Calcimycin; Dose-Response Relationship, Drug; Electron Transport; Enzyme Inhibitors; Ionophores; Microscopy, Confocal; Mitochondria; Oxygen; PC12 Cells; Peroxynitrous Acid; Phospholipases A; Phospholipases A2; Protein Isoforms; Quinacrine; Rats; Reactive Oxygen Species | 2002 |
Involvement of oxidative stress in bee venom-induced inhibition of Na+/glucose cotransporter in renal proximal tubule cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Bee Venoms; Biological Transport, Active; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Kidney Tubules, Proximal; Lipid Peroxides; Male; Monosaccharide Transport Proteins; Oxidative Stress; Phospholipases A; Quinacrine; Rabbits; Time Factors | 2002 |
Downregulation of nNOS and synthesis of PGs associated with endotoxin-induced delay in gastric emptying.
Topics: Animals; Arachidonic Acid; Cyclooxygenase Inhibitors; Endotoxins; Enzyme Inhibitors; Food; Gastric Emptying; Indazoles; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitrobenzenes; Phospholipases A; Prostaglandins; Pyloric Antrum; Quinacrine; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonamides | 2002 |
Progesterone regulates IL12 expression in pregnancy lymphocytes by inhibiting phospholipase A2.
Topics: Antibodies; Arachidonic Acid; Enzyme Inhibitors; Female; Humans; Interleukin-12; Lipopolysaccharides; Lymphocytes; Phospholipases A; Phospholipases A2; Pregnancy; Pregnancy Proteins; Progesterone; Quinacrine; Suppressor Factors, Immunologic | 2003 |
Role of phospholipase A2 activation and calcium in CYP2E1-dependent toxicity in HepG2 cells.
Topics: alpha-Tocopherol; Arachidonic Acid; Aristolochic Acids; Calcium; Calpain; Cell Survival; Cytochrome P-450 CYP2E1; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flow Cytometry; Humans; Intracellular Membranes; Lipid Peroxidation; Membrane Potentials; Mitochondria; Models, Biological; Oxidative Stress; Phospholipases A; Phospholipases A2; Protein-Tyrosine Kinases; Quinacrine; Thiobarbituric Acid Reactive Substances; Time Factors; Tumor Cells, Cultured | 2003 |
Advanced glycation end products stimulate an enhanced neutrophil respiratory burst mediated through the activation of cytosolic phospholipase A2 and generation of arachidonic Acid.
Topics: Acetylcysteine; Adult; Arachidonic Acid; Arachidonic Acids; Cells, Cultured; Enzyme Inhibitors; Glycation End Products, Advanced; Group IV Phospholipases A2; Humans; Indomethacin; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Organophosphonates; Oxidation-Reduction; Phospholipases A; Phospholipases A2; Quinacrine; Reactive Oxygen Species; Respiratory Burst; Vascular Diseases | 2003 |
Brain phospholipase C/diacylglycerol lipase are involved in bombesin BB2 receptor-mediated activation of sympatho-adrenomedullary outflow in rats.
Topics: Adrenal Medulla; Animals; Arachidonic Acid; Bombesin; Brain; Cyclohexanones; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epinephrine; Estrenes; Gastrin-Releasing Peptide; Injections, Intraventricular; Lipoprotein Lipase; Male; Neurokinin B; Norepinephrine; Peptides, Cyclic; Phospholipases A; Phospholipases A2; Pyrrolidinones; Quinacrine; Rats; Rats, Wistar; Receptors, Bombesin; Sympathetic Nervous System; Type C Phospholipases | 2005 |
alpha(2)-Adrenergic receptors activate MAPK and Akt through a pathway involving arachidonic acid metabolism by cytochrome P450-dependent epoxygenase, matrix metalloproteinase activation and subtype-specific transactivation of EGFR.
Topics: Adrenergic alpha-Agonists; Animals; Antifungal Agents; Arachidonic Acid; Cytochrome P-450 Enzyme System; Enzyme Activation; Enzyme Inhibitors; Epinephrine; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Humans; Ketoconazole; MAP Kinase Signaling System; Matrix Metalloproteinases; Oxidoreductases; PC12 Cells; Phosphatidylinositol 3-Kinases; Protein Isoforms; Proto-Oncogene Proteins c-akt; Quinacrine; Rats; Receptor, trkA; Receptors, Adrenergic, alpha-2; src-Family Kinases; Transcriptional Activation | 2006 |
Blockade of arachidonic acid pathway induces sprouting in the adult but not in the neonatal uncrossed retinotectal projection.
Topics: Animals; Animals, Newborn; Arachidonic Acid; Enzyme Inhibitors; Immunohistochemistry; Indomethacin; Lipoxygenase Inhibitors; Masoprocol; Neuronal Plasticity; Phospholipases A; Phospholipases A2; Prostaglandin-Endoperoxide Synthases; Quinacrine; Rats; Retina; Signal Transduction; Synapses; Synaptic Transmission; Visual Pathways | 2006 |
Roles of brain phosphatidylinositol-specific phospholipase C and diacylglycerol lipase in centrally administered histamine-induced adrenomedullary outflow in rats.
Topics: Adrenal Medulla; Animals; Arachidonic Acid; Brain; Bridged-Ring Compounds; Cyclohexanones; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epinephrine; Estrenes; Histamine; Injections, Intraventricular; Lipoprotein Lipase; Male; Norbornanes; Norepinephrine; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoinositide Phospholipase C; Phospholipases A; Phospholipases A2; Phospholipid Ethers; Pyrrolidinones; Quinacrine; Rats; Rats, Wistar; Signal Transduction; Thiocarbamates; Thiones; Time Factors | 2007 |
Hydrogen peroxide increases [3H]-2-deoxyglucose uptake via MAPKs, cPLA2, and NF-kappaB signaling pathways in mouse embryonic stem cells.
Topics: Animals; Antioxidants; Arachidonic Acid; Deoxyglucose; Dose-Response Relationship, Drug; Embryonic Stem Cells; Enzyme Activation; Gene Expression Regulation; Glucose Transporter Type 1; Group IV Phospholipases A2; Hydrogen Peroxide; Kinetics; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; NF-kappa B; Nitriles; Protein Kinase Inhibitors; Quinacrine; Sulfones; Time Factors; Tritium | 2007 |
Effect of inhibitors of arachidonic acid conversion in platelets on thrombin-fibrinogen interaction and thrombin tolerance.
Topics: Animals; Arachidonic Acid; Aspirin; Blood Platelets; Dose-Response Relationship, Drug; Fibrinogen; Imidazoles; Male; Platelet Aggregation; Quinacrine; Rats; Thrombin | 2007 |
Quinacrine protects neuronal cells against heat-induced injury.
Topics: Animals; Animals, Newborn; Apoptosis; Arachidonic Acid; Hot Temperature; Microscopy, Atomic Force; Necrosis; Neurons; Phospholipases A2; Quinacrine; Rats; Rats, Wistar | 2009 |
Loss of heart phospholipid arachidonic acid without phospholipid peroxidation in anaesthetized rats rewarmed after prolonged deep hypothermia.
Topics: Animals; Arachidonic Acid; Blood Pressure; Cardiac Output; Heart; Heart Rate; Hypothermia, Induced; In Vitro Techniques; Lipid Peroxidation; Male; Myocardial Contraction; Myocardium; Phospholipids; Quinacrine; Rats; Rats, Wistar; Rewarming | 2009 |
Role of phospholipase A2 pathway in regulating activation of Bufo arenarum oocytes.
Topics: Animals; Arachidonic Acid; Bufo arenarum; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Female; Inositol 1,4,5-Trisphosphate Receptors; Melitten; Metabolic Networks and Pathways; Oocytes; Phospholipases A2; Phospholipases A2, Cytosolic; Quinacrine; Ryanodine Receptor Calcium Release Channel | 2013 |
Cysteinyl leukotrienes mediate the response of submucosal ganglia from rat colon to bradykinin.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Bradykinin; Calcium; Colon; Cysteine; Cytosol; Female; Fura-2; Ganglia; Intestinal Mucosa; Leukotriene D4; Leukotrienes; Lipoxygenases; Phospholipases A2; Propionates; Prostaglandin-Endoperoxide Synthases; Quinacrine; Quinolines; Rats; Rats, Wistar; Receptors, Bradykinin | 2012 |
Involvement of the arachidonic acid cascade in the hypersusceptibility to pentylenetetrazole-induced seizure during diazepam withdrawal.
Topics: Animals; Arachidonic Acid; Convulsants; Cyclooxygenase Inhibitors; Diazepam; Diclofenac; Enzyme Inhibitors; Lipoxygenase; Lipoxygenase Inhibitors; Male; Masoprocol; Mice; Mice, Inbred Strains; Pentylenetetrazole; Phospholipase A2 Inhibitors; Prostaglandin-Endoperoxide Synthases; Psychotropic Drugs; Quinacrine; Seizures; Substance Withdrawal Syndrome | 2012 |
Involvement of PLA2, COX and LOX in Rhinella arenarum oocyte maturation.
Topics: Animals; Arachidonic Acid; Bufo arenarum; Cells, Cultured; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Indomethacin; Lactones; Lipoxygenase; Masoprocol; Melitten; Oocytes; Oogenesis; Phospholipases A2; Progesterone; Prostaglandin-Endoperoxide Synthases; Quinacrine; Sulfones | 2014 |