quetiapine-fumarate has been researched along with cholest-5-ene-3-4-diol* in 3 studies
3 other study(ies) available for quetiapine-fumarate and cholest-5-ene-3-4-diol
| Article | Year |
|---|---|
Was 4β-hydroxycholesterol ever going to be a useful marker of CYP3A4 activity?
Topics: Biomarkers; Cytochrome P-450 CYP3A; Humans; Hydroxycholesterols; Quetiapine Fumarate | 2018 |
Gjestad et al. reply to 'Was 4β-hydroxycholesterol ever going to be a useful marker of CYP3A4 activity?' by Neuhoff and Tucker.
Topics: Biomarkers; Cytochrome P-450 CYP3A; Humans; Hydroxycholesterols; Quetiapine Fumarate | 2018 |
4β-Hydroxycholesterol level significantly correlates with steady-state serum concentration of the CYP3A4 substrate quetiapine in psychiatric patients.
4β-Hydroxycholesterol (4βOHC) is sensitive towards induction or inhibition of CYP3A4, but its potential usefulness as a dosing biomarker remains to be demonstrated. The aim of this study was to investigate the correlation between 4βOHC levels and steady-state concentrations (Css) of quetiapine, a CYP3A4 substrate with high presystemic metabolism, in psychiatric patients.. Serum samples from 151 patients treated with quetiapine as immediate release (IR; n = 98) or slow release (XR; n = 53) tablets were included for analysis of 4βOHC. In all patients, Css of quetiapine had been measured at trough level, i.e. 10-14 and 17-25 h post-dosing for IR and XR tablets, respectively. Correlations between 4βOHC levels and dose-adjusted Css (C/D ratios) of quetiapine were tested by univariate (Spearman's) and multivariate (multiple linear regression) analyses. Gender, age (≥60 vs. <60 years) and tablet formulation were included as potential covariates in the multivariate analysis.. Correlations between 4βOHC levels and quetiapine C/D ratios were highly significant both for IR- and XR-treated patients (P < 0.0001). Estimated Spearman r values were -0.47 (95% confidence interval -0.62, -0.30) and -0.56 (-0.72, -0.33), respectively. The relationship between 4βOHC level and quetiapine C/D ratio was also significant in the multiple linear regression analysis (P < 0.001), including gender (P = 0.023) and age (P = 0.003) as significant covariates.. The present study shows that 4βOHC level is significantly correlated with steady-state concentration of quetiapine. This supports the potential usefulness of 4βOHC as a phenotype biomarker for individualized dosing of quetiapine and other drugs where systemic exposure is mainly determined by CYP3A4 metabolism. Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Antipsychotic Agents; Biomarkers, Pharmacological; Cytochrome P-450 CYP3A; Delayed-Action Preparations; Female; Humans; Hydroxycholesterols; Male; Mental Disorders; Middle Aged; Prospective Studies; Quetiapine Fumarate; Sex Factors; Tablets; Young Adult | 2017 |