quercetin-3-o-glucuronide and saccharolactone

quercetin-3-o-glucuronide has been researched along with saccharolactone* in 1 studies

Other Studies

1 other study(ies) available for quercetin-3-o-glucuronide and saccharolactone

ArticleYear
Vascular deconjugation of quercetin glucuronide: the flavonoid paradox revealed?
    Molecular nutrition & food research, 2011, Volume: 55, Issue:12

    The dietary flavonoid quercetin exerts protective cardiovascular effects. Because quercetin is rapidly metabolized into less active or inactive glucuronidated metabolites and the plasma concentrations of free quercetin are very low, a huge amount of scientific data generated along decades with the unconjugated compounds in vitro has been questioned. We aimed to determine whether glucuronidated quercetin can deconjugate in situ and whether deconjugation leads to a biological effect.. Quercetin and quercetin-3-O-glucuronide (Q3GA) were perfused through the isolated rat mesenteric vascular bed. Quercetin was rapidly metabolized in the mesentery. In contrast, the decay of Q3GA was slower and was accompanied by a progressive increase of quercetin in the perfusate and in the tissue over 6 h, which was prevented by the β-glucuronidase inhibitor saccharolactone. Incubation of mesenteric arterial rings mounted in a wire myograph with Q3GA for ≥1 h resulted in a significant inhibition of the contractile response which was also prevented by saccharolactone. Moreover, the intravenous administration of Q3GA resulted in a slow onset and sustained blood pressure lowering effect, demonstrating for the first time that Q3GA has effects in vivo.. We propose that Q3GA behaves as a quercetin carrier in plasma, which deconjugates in situ releasing the aglycone which is the final effector.

    Topics: Administration, Oral; Animals; Blood Pressure; Cardiovascular Agents; Glucaric Acid; Glucuronidase; Glycoproteins; In Vitro Techniques; Injections, Intravenous; Male; Mesenteric Arteries; Myocardial Contraction; Quercetin; Rats

2011
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