pyruvic acid has been researched along with nad in 431 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 136 (31.55) | 18.7374 |
| 1990's | 89 (20.65) | 18.2507 |
| 2000's | 96 (22.27) | 29.6817 |
| 2010's | 87 (20.19) | 24.3611 |
| 2020's | 23 (5.34) | 2.80 |
| Authors | Studies |
|---|---|
| Berry, MN; Gregory, RB; Phillips, JW | 1 |
| Cogan, TM; Doonan, S; FitzGerald, RJ; McKay, LL | 1 |
| Alonso-Llamazares, AM; de Arriaga, D; Soler, J | 1 |
| Aw, TY; Jones, DP; Kowalski, DP; Park, Y | 1 |
| Hottinger, H; Hunziker, PE; Kochhar, S; Leong-Morgenthaler, P | 1 |
| Butterworth, RF; Qureshi, IA; Ratnakumari, L | 1 |
| Loushchak, VI | 1 |
| Hugenholtz, J; Snoep, JL; Starrenburg, MJ; Teixeira de Mattos, MJ | 1 |
| Chang, GG; Chiou, SH; Huang, SM; Lee, HJ | 1 |
| Ayuso, MS; González-Manchón, C; Martín-Requero, A; Parrilla, R | 1 |
| Corona, N; Devars, S; López-Gómez, F; Moreno-Sánchez, R; Uribe, A | 1 |
| Chambers, RP; Dillon, AR; Whitmire, DR | 1 |
| Bohnensack, R; Schönfeld, P | 1 |
| Carriero, D; Piomelli, S; Seaman, C; Tilton, WM | 1 |
| Chang, GG; Chiou, SH; Huang, SM | 1 |
| Bohnensack, R; Fritz, S | 1 |
| Javed, MH | 1 |
| Neijssel, OM; Postma, PW; Snoep, JL; Teixeira de Mattos, MJ | 1 |
| de Groot, CJ; Feller, N; Wanders, RJ; Wijburg, FA | 1 |
| Dargel, R; Dietrich, N; Haufe, CC; Schulze, HP | 1 |
| Vlessis, AA | 1 |
| Azzi, A; Capuano, F; Di Paola, M; Papa, S | 1 |
| Chang, GG; Chiou, SH; Lee, HJ | 1 |
| Fernandez-Romero, JM; Luque de Castro, MD; Valcarcel, M | 1 |
| Erecinska, M; Meglasson, MD; Nelson, D; Smith, KM | 1 |
| Doi, S; Kobayashi, K; Negoro, S; Okada, H; Urabe, I | 1 |
| Anderson, VE; LaReau, RD | 1 |
| Bhattacharyya, A; Hoskins, DD; Vijayaraghavan, S | 1 |
| Matsuno, T | 1 |
| Pall, ML; Robertson, CK | 1 |
| Wade, TG; Whiteley, CG | 1 |
| Balaban, RS; Koretsky, AP | 1 |
| Aprille, JR; Tullson, PC | 1 |
| Taegtmeyer, H | 1 |
| Bessam, H; Foucher, B; Mareck, AM | 1 |
| Laustiola, K | 1 |
| Lardy, HA; Warnette-Hammond, ME | 1 |
| Baudet, A; Goodyer, P; Robinson, BH; Ward, J | 1 |
| Marsac, C; Stansbie, D; Wallace, SJ | 1 |
| Casazza, JP; Veech, RL | 1 |
| Chin, NW; Hitti, IF; Lanks, KW | 1 |
| Inui, H; Kitaoka, S; Miyatake, K; Nakano, Y; Ono, K | 1 |
| Clary, GL; Guynn, RW | 1 |
| Elnageh, KM; Gaitonde, MK | 1 |
| Muronetz, VI; Nagradova, NK; Vener, AV | 1 |
| Geelen, MJ; Kunz, W; Schönfeld, P; Wojtczak, AB; Wojtczak, L | 1 |
| Hassan, MN; Thakar, JH | 1 |
| Kuroda, Y; Naito, E | 1 |
| Malaisse, WJ; Sener, A | 1 |
| Bergqvist, Y; Hed, K; Karlberg, B | 1 |
| Lohmann, C; Lohmann, W | 1 |
| Bachelard, HS; Cox, DW; Garofalo, O | 1 |
| Kaneoka, T; Shimizu, H; Shirakawa, K; Taguchi, S | 1 |
| Grunnet, N; Vind, C | 1 |
| Heikkila, RE; Nicklas, WJ; Vyas, I | 1 |
| Kamiyama, Y; Koizumi, K; Morimoto, T; Nitta, N; Noguchi, M; Taki, Y; Tanaka, A; Ukikusa, M; Yamamoto, S; Yokoo, N | 1 |
| Atkinson, T; Barstow, DA; Chia, WN; Clarke, AR; Holbrook, JJ; Wigley, DB | 1 |
| Rahmatullah, M; Roche, TE | 1 |
| Dry, IB; Wiskich, JT | 1 |
| Kamiyama, Y; Noguchi, M; Ozawa, K; Shimahara, Y; Taki, Y; Tanaka, A | 1 |
| Henriksson, J; Katz, A; Sahlin, K | 1 |
| Ivanov, MV; Kube, D; Nagradova, NK; Permiakov, EA; Shnyrov, VL | 1 |
| Aleksandrowicz, Z; Swierczyński, J; Zelewski, L | 1 |
| Hjelle, JJ | 1 |
| Brindle, KM; Campbell, ID; Simpson, RJ | 2 |
| Curi, R; Newsholme, EA; Newsholme, P | 1 |
| Chakraborty, J; Ryle, PR; Thomson, AD | 1 |
| Fagan, JM; Tischler, ME | 2 |
| Harrison, SP | 1 |
| Chua, BH; Kleinhans, BJ | 1 |
| Marsh, CA | 1 |
| Sestoft, L | 1 |
| Cuezva, JM; Patel, MS | 1 |
| Olson, MS; Steinhelper, ME | 1 |
| Siemes, H | 1 |
| Adamson, I; Nylen, EG; Pande, SV; Wrogemann, K | 1 |
| Giacomelli, F; Kuo, TH; Wiener, J | 1 |
| García-Sancho, J | 1 |
| Davisson, VJ; Schulz, AR | 1 |
| Gardiner, NS; Whiteley, CG | 1 |
| Stern, A; Thornalley, PJ | 2 |
| Clarke, AR; Hart, KW; Holbrook, JJ; Waldman, AD | 1 |
| Olomucki, A; Pho, DB; Thomé, F | 1 |
| Babin, W; Kittlick, PD | 1 |
| Kaminsky, YG; Kosenko, EA | 1 |
| Haynes, RC; Sistare, FD | 2 |
| Snijders, PM; Valkenburg, PW; van der Meer, C | 1 |
| Csenkér, E; Diószeghy, P; Mechler, F; Molnár, L | 1 |
| Avi-Dor, Y; Diamant, P; Ravid, K | 1 |
| Gorbach, ZV; Maglysh, SS; Ostrovskiĭ, IuM | 1 |
| Fujii, K; Horio, T; Takizawa, N; Yamashita, J; Yamauti, J | 1 |
| Best, L; Malaisse, WJ; Malaisse-Lagae, F; Sener, A | 1 |
| Busto, F; Cadenas, E; de Arriaga, D; Soler, J | 2 |
| Gabriel, M; Guerin, MC; Larcher, D; Marchand, J; Torreilles, J | 1 |
| Kaminsky, YG; Kondrashova, MN; Kosenko, EA | 1 |
| Kimura, RE; Thulin, G; Warshaw, JB | 1 |
| Ivanov, MV; Kube, D; Nagradova, NK | 1 |
| Long, GL; Philipp, R; Trommer, WE | 1 |
| Buxton, DB; Hanahan, DJ; Olson, MS | 1 |
| Cook, PF; Harris, BG; Kiick, DM; Park, SH | 1 |
| Dora, E | 1 |
| Fiolitakis, E; Kula, MR; Wandrey, C; Wichmann, U | 1 |
| Aleksandrowicz, Z; Scisłowski, PW; Skorkowski, EF; Swierczyński, J | 1 |
| Busto, F; de Arriaga, D; Soler, J | 1 |
| Chernyak, BV; Drachev, VA; Nikolaeva, NG | 1 |
| Schrimsher, JL; Taylor, KB | 1 |
| Guynn, RW; Kuo, YJ; Shanbour, LL | 1 |
| Gibbs, PA; Wood, JM; Woods, LF | 1 |
| Debuysere, MS; Olson, MS; Patel, TB; Scholz, R | 1 |
| Danson, MJ; Hale, G; Perham, RN | 1 |
| Frey, PA | 1 |
| Engel, PC; Gould, KG | 1 |
| Yamamoto, S | 1 |
| Caparrotta, L; Fassina, G; Scotini, E; Tessari, F | 1 |
| Ayromlooi, J; Das, DK; Neogi, A | 1 |
| Christophe, J; Hutton, JC; Malaisse, WJ; Malaisse-Legae, F; Sener, A | 1 |
| Heidrich, JE; Hunsaker, LA; Vander Jagt, DL | 1 |
| McKeehan, KA; McKeehan, WL | 1 |
| Brindle, KM; Brown, FF; Campbell, ID; Foxall, DL; Simpson, RJ | 1 |
| Nicolau, J; Sassaki, KT | 1 |
| Maughan, RJ | 1 |
| Cadenas, E; De Arriaga, D; Soler, J | 1 |
| Guerin, MC; Marchand, J; Torreilles, J | 1 |
| Jones, DP; Kennedy, FG | 1 |
| George, HA; Smibert, RM | 1 |
| Brandt, RB | 1 |
| Goldberg, E; Lee, CY; Yuan, JH | 1 |
| Aleksandrowicz, Z; Scisłowski, P; Swierczyński, J; Zelewski, L | 1 |
| Degrel, I; Molnár, L; Szabó, E | 1 |
| Momsen, G | 1 |
| Gregersen, N | 1 |
| Cutten, AE | 1 |
| Popova, SV; Reich, JG | 1 |
| Azumi, T; Naujocks, S; Regitz, V; Schaper, W; Stephan, H | 1 |
| Ansari, AA | 1 |
| Cederbaum, AI; Dicker, E | 1 |
| De Bolle, X; Depiereux, E; Feytmans, E; Vinals, C | 1 |
| Ashruf, JF; Bruining, HA; Coremans, JM; Ince, C | 1 |
| Higashino, K; Moriwaki, Y; Suda, M; Takahashi, S; Yamamoto, T | 1 |
| Khan, S; Niknahad, H; O'Brien, PJ | 1 |
| Kanno, T; Maekawa, M | 1 |
| Crestanello, JA; Kamelgard, J; Whitman, GJ | 1 |
| Catelloni, F; Fontaine, E; Keriel, C; Leverve, XM; Rigoulet, M; Sibille, B | 1 |
| Scopes, RK | 1 |
| Cottam, GL; Gitomer, WL; Miller, BC | 1 |
| Javed, MH; Qureshi, MA; Waqar, MA | 1 |
| Hussain, AN; Ishaq, M; Javed, MU; Waqar, MA; Yousuf, FA | 1 |
| Burstein, C; Geloso-Meyer, A; Haouz, A | 1 |
| Scaduto, RC | 1 |
| Chagoya de Sánchez, V; Díaz-Muñoz, M; Hernández-Muñoz, R | 1 |
| Chapman, RA; Minezaki, KK; Suleiman, MS | 1 |
| Juurlink, BH | 1 |
| Burgner, JW; Callender, R; Clarke, A; Deng, H; Holbrook, JJ; Zheng, J | 1 |
| Miles, RJ; Taylor, RR; Varsani, H | 1 |
| Bünger, R; Mallet, RT | 1 |
| Boeker, EA; Holmes, LD; Schiller, MR | 1 |
| Friedman, S; Gao, JP; Lanks, KW | 1 |
| Davis, EJ; Dietzen, DJ | 1 |
| Engel, PC; Syed, SE | 1 |
| Day, DA; Millar, AH; Whelan, J; Wiskich, JT | 1 |
| Lindsay, JG; Miller, C; Sanderson, SJ | 1 |
| Bracht, A; Constantin, J; Ishii-Iwamoto, EL; Nascimento, EA; Salgueiro-Pagadigorria, CL | 1 |
| Javed, MU; Waqar, MA | 1 |
| Civelek, VN; Corkey, BE; Deeney, JT; Fusonie, GE; Tornheim, K | 1 |
| Delaive, E; Delforge, D; Devreese, B; Dieu, M; Remacle, J; Van Beeumen, J | 1 |
| Diez-Gonzalez, F; Hunter, JB; Russell, JB | 1 |
| Bazotte, RB; Brunaldi, K; Ferraz, M; Oliveira, CE | 1 |
| Barron, JT; Gu, L; Parrillo, JE | 1 |
| Cocaign-Bousquet, M; Garrigues, C; Lindley, ND; Loubiere, P | 1 |
| Flikweert, MT; Pronk, JT; van Dijken, JP | 1 |
| Ishihara, T; Kondo, S; Naka, T; Shimizu, E; Yorifuji, T | 1 |
| Asahina, T; Harada, N; Hidaka, H; Ikebuchi, M; Kashiwagi, A; Kikkawa, R; Nishio, Y; Obata, T; Saeki, Y; Takahara, N; Taki, H; Tanaka, Y | 1 |
| Bisswanger, H; Hennig, J; Hübner, G; Kern, G; Neef, H; Spinka, M | 1 |
| Neijssel, OM; Snoep, JL; Teixeira de Mattos, MJ | 1 |
| Bünger, R; Lasley, RD; Martin, BJ; Mentzer, RM; Valdivia, HH | 1 |
| He, Z; Spain, JC | 1 |
| Baio, DL; Cunningham, CC; Czyz, CN; Ivester, P; Van Horn, CG | 1 |
| Chait, BT; Erickson, SD; Haller, I; Manning, JM; Martinez del Pozo, A; Petsko, G; Ringe, D; Soda, K; van Ophem, PW; Yoshimura, T | 1 |
| Brambilla, L; Cantoni, O; Guidarelli, A; Palomba, L; Sestili, P | 1 |
| Deck, LM; Gomez, MS; Hunsaker, LA; Makler, MT; Piper, RC; Royer, RE; Vander Jagt, DL | 1 |
| Lushchak, VI | 1 |
| Doughty, MJ | 1 |
| Adler, L; Ansell, R; Gustafsson, L; Larsson, C; Påhlman, IL; Rigoulet, M | 1 |
| Coffe, V; Hernández-Muñoz, R; Salceda, R; Vilchis, C | 1 |
| Ivnitskiĭ, IuIu; Nosov, AV; Sofronov, GA | 1 |
| Moiseenok, AG; Omelyanchik, SN; Slyshenkov, VS; Trebukhina, RV; Wojtczak, L | 1 |
| Baker, PJ; Rice, DW; Sawa, Y; Sedelnikova, SE; Shibata, H | 1 |
| Hoefnagel, MH; Wiskich, JT | 1 |
| Chun, YS; Kim, MS; Kwak, SJ; Park, JW; Park, SC; Park, YC | 1 |
| Coiffard, C; Coiffard, LJ; De Roeck-Holtzhauer, Y; Rivalland, P; Verhulst, C | 1 |
| Devin, A; Espié, P; Leverve, X; Piquet, MA; Rigoulet, M; Sibille, B | 1 |
| Chamblee, BB; Deck, LM; Hernandez, VM; Hunsaker, LA; Makler, MT; Malone, RR; Piper, RC; Royer, RE; Torres, JE; Vander Jagt, DL | 1 |
| Bailey, SM; Cunningham, CC | 1 |
| Aizawa, S; Aizawa, T; Akanuma, Y; Eto, K; Kadowaki, T; Kasai, H; Kishimoto, T; Kubota, N; Murayama, S; Sugiyama, T; Takahashi, N; Terauchi, Y; Tsubamoto, Y; Yamauchi, N; Yazaki, Y | 1 |
| Ahrens, K; Deckwer, W; Menzel, K; Zeng, A | 1 |
| Brambilla, L; Cantoni, O; Clementi, E; Guidarelli, A | 1 |
| Clarke, AR; Dafforn, TR; Dempsey, CE; Eszes, CM; Hewitt, CO; Holbrook, JJ; Moreton, KM; Sessions, RB; Takei, J | 1 |
| Gemeinhardt, H; Greulich, KO; Monajembashi, S; Nasanshargal, B; Schäfer, B; Uhl, V | 1 |
| Holm, S; Möller, A; Ström, D | 1 |
| Hill, SA; Leaver, CJ; Millar, AH | 1 |
| Ainscow, EK; Brand, MD | 1 |
| Gardner, DK; Lane, M | 1 |
| Burelle, Y; Fillipi, C; Leverve, X; Péronnet, F | 1 |
| Baker, JC; Kasten, S; Peng, T; Roche, TE; Yan, X | 1 |
| Behrens, MM; Choi, DW; Sheline, CT | 1 |
| Aozasa, K; Fujii, J; Kanno, H; Miwa, H; Taniguchi, N | 1 |
| Siedow, JN; Umbach, AL | 1 |
| Ishihara, H; Wollheim, CB | 1 |
| Alexeeva, S; de Kort, B; de Mattos, MJ; Hellingwerf, KJ; Sawers, G | 1 |
| Cechowska-Pasko, M; Pałka, J | 1 |
| Flores, CL; Gancedo, C; Petit, T; Rodríguez, C | 1 |
| Babij, J; Hollomon, D; Joseph-Horne, T; Sessions, RB; Wood, PM | 1 |
| Cook, PF; Karsten, WE; Liu, D | 1 |
| Jones, AR; Piccolo, F | 1 |
| Eliasson, A; Hahn-Hägerdal, B; Wahlbom, CF | 1 |
| Abbe, K; Takahashi, N; Takahashi-Abbe, S; Tamazawa, Y; Yamada, T | 1 |
| Lang, HJ; Obrosova, IG; Stevens, MJ | 1 |
| Akimoto, LS; Bazotte, RB; Lopes, G; Pedrinho, SR | 1 |
| Alberty, RA | 1 |
| Chang, K; Ido, Y; Williamson, JR; Woolsey, TA | 1 |
| Banaszak, LJ; Bell, JK; Thompson, JR; Viola, RE; Wright, SK; Yennawar, HP | 1 |
| Devin, A; Guérin, B; Leverve, X; Nogueira, V; Rigoulet, M | 1 |
| Hunt, NH; Maitland, A; Rae, C; Sanni, LA; Stocker, R | 1 |
| Antinozzi, PA; Ishihara, H; Newgard, CB; Wollheim, CB | 1 |
| Allen, JC; Kahn, AM; Zhang, S | 1 |
| Andalis, AA; Culotta, VC; Defossez, PA; Fink, GR; Guarente, L; Kaeberlein, M; Lin, SJ; Sturtz, LA | 1 |
| Alano, CC; Chen, Y; Swanson, RA; Ying, W | 1 |
| Metcalf, WW; van der Donk, WA; Vrtis, JM; White, AK | 1 |
| Capacchione, J; Dubois, D; Karaian, J; Keneally, R; Mongan, PD; Sharma, P; West, S | 1 |
| van Milgen, J | 1 |
| Ortiz de Montellano, PR; Puchkaev, AV; Wakagi, T | 1 |
| Fang, YH; Geiger, PC; Han, YS; Prakash, YS; Sieck, GC; Zhan, WZ | 1 |
| Mazzio, EA; Soliman, KF | 1 |
| Chang, I; Cho, N; Koh, JY; Lee, MS | 1 |
| LITTLEFIELD, JW; SANADI, DR | 1 |
| KATZ, S | 1 |
| KLINGMULLER, V; MARTINI, GA; STROHMEYER, G | 1 |
| FROMM, HJ | 1 |
| COSTILOW, RN; SIMMONS, RJ | 1 |
| LAUDAHN, G | 1 |
| BRILL, WJ; SAGERS, RD; VALENTINE, RC | 1 |
| BENZIMAN, M; KLEIN, SM; SAGERS, RD | 1 |
| BURK, D; WOODS, M | 1 |
| GREENE, NM; TALNER, NS | 1 |
| BOYER, PD; SILVERSTEIN, E | 1 |
| HAAF, AS; WITTENBERGER, CL | 1 |
| NAGARAJAN, K | 1 |
| WILLIAMSON, JR | 1 |
| COOPER, RA; ITIABA, K; KORNBERG, HL | 1 |
| BERGQUIST, A; KIRITANI, K; NARISE, S; WAGNER, RP | 1 |
| Chang, K; Ido, Y; Williamson, JR | 1 |
| Elling, RA; Kavanagh, KL; Wilson, DK | 1 |
| Carbajal, RC; Coffe, V; Salceda, R | 1 |
| SPIRTES, MA; WEINHOUSE, S; WENNER, CE | 1 |
| Bracht, A; Constantin, J; Gimenes, D; Lopez, CH; Suzuki-Kemmelmeier, F | 1 |
| Koh, JY; Lee, JY; Lee, SE; Yoo, MH; Yoon, YH | 1 |
| Kunz, WS; Wallesch, CW; Wiedemann, FR; Winkler-Stuck, K | 1 |
| Cecchini, G; Kotlyar, AB; Maklashina, E | 1 |
| Head, WS; Piston, DW; Rocheleau, JV | 1 |
| Cabrera, ME; Salem, JE; Stanley, WC | 1 |
| El-Zahab, B; Jia, H; Wang, P | 1 |
| Inui, M; Kawaguchi, H; Murakami, S; Okino, S; Vertès, AA; Yukawa, H | 1 |
| Ahmad, M; Arcuino, E; Oeckler, RA; Olson, SC; Wolin, MS | 1 |
| Doi, A; Fujita, S; Matsuno, H; Miyano, S; Nagasaki, M | 1 |
| Bratus', LV; Havenauskas, BL; Man'kovs'ka, IM; Nazarenko, AI; Nosar, VI | 1 |
| Gygi, SP; Haas, W; Lerin, C; Puigserver, P; Rodgers, JT; Spiegelman, BM | 1 |
| Borodina, I; Eliasson, A; Nielsen, J; Schöller, C | 1 |
| Antosiewicz, J; Falcioni, G; Fedeli, D; Gabbianelli, R; Olek, RA; Popinigis, J | 1 |
| Chen, J; Li, HZ; Li, Y; Liu, LM | 1 |
| Fukamachi, H; Nakano, Y; Nishiya, Y; Yoshida, Y; Yoshimura, M | 1 |
| Chuang, CK; Ho, SC; Hsieh, WS; Lin, DS; Lin, SP; Wang, TJ; Yeung, CY | 1 |
| Chen, J; Du, G; Li, Y; Liu, L | 1 |
| Carobbio, S; Maechler, P; Rubi, B | 1 |
| Chen, J; Du, G; Li, Y; Liu, L; Shi, Z | 1 |
| Berkowitz, BA; Diederen, RM; Starnes, CA; Winkler, BS | 1 |
| Kahn, AM; Yang, M | 1 |
| Hirai, K; James, TL; Kelly, M; Litt, L; Swanson, RA; Yang, GY; Ying, W; Zeng, J | 1 |
| Goodman, RH; Nottke, AC; Piston, DW; Rocheleau, JV; Wang, SY; Zhang, Q | 1 |
| Bergold, PJ; Gilbert, E; Ludvig, N; Tang, JM | 1 |
| Chen, J; Du, G; Li, Y; Liu, L; Zhu, Y | 1 |
| Carroll, J; Duchen, MR; Dumollard, R; Ward, Z | 1 |
| Cao, L; Chen, X; Kong, Q; Zhang, A | 1 |
| Kim, TY; Koh, JY; Kyu Kim, D; Yi, JS | 1 |
| Ishida, Y; Ishihama, A; Ogasawara, H; Yamada, K; Yamamoto, K | 1 |
| Dietrich, LE; Newman, DK; Price-Whelan, A | 1 |
| Bolívar, F; Gosset, G; Martinez, A; Merino, E; Romero, S | 1 |
| Collins, RF; Derrick, JP; Saleem, M | 1 |
| Quaytman, SL; Schwartz, SD | 1 |
| Bracht, A; Bracht, F; Broetto-Biazon, AC; Constantin, J; de Sá-Nakanishi, AB; Kelmer-Bracht, AM; Lopez, CH | 1 |
| Hemmi, H; Ito, T; Naka, T; Takahashi, K; Yoshimura, T | 1 |
| Sakurai, T; Takata, T; Wang, X; Yokono, K | 1 |
| Belsham, DD; Cheng, H; Isoda, F; Mobbs, CV | 1 |
| Abe, Y; Ichikawa, M; Ito, K; Ito, T; Ito, Y; Ito-Inaba, Y; Kato, Y; Koiwa, H; Matsukawa, K; Morohashi, M; Onda, Y; Otsuka, M | 1 |
| JANDORF, BJ; LARNER, J; SUMMERSON, WH | 1 |
| Agren, D; Berthold, CL; Kapoor, S; Oehlmann, W; Schneider, G; Singh, M; Stehr, M | 1 |
| Bracht, A; Bracht, F; de Sá-Nakanishi, AB; Kelmer-Bracht, AM; Padilha, F; Yamamoto, NS | 1 |
| Nakamori, T; Ohno, Y; Suye, S; Zheng, H | 1 |
| Callender, R; Gulotta, M; Zhadin, N | 1 |
| Ramachandran, R; Tripathi, SM | 1 |
| Richards, JG; Sardella, BA; Schulte, PM | 1 |
| Gao, XF; Ju, X; Li, YS; Zhang, J; Zhao, YY; Zheng, J | 1 |
| Grieshaber, MK; Mueller, A; Schmitt, L; Smits, SH | 1 |
| Hagopian, K; Ramsey, JJ; Weindruch, R | 1 |
| Chen, J; Dong, Z; Du, G; Li, X; Liu, L | 1 |
| Liu, W; Wang, P; Zhang, S | 1 |
| Grishina, EV; Khaustova, YV; Kuz'mich, MK; Maevskii, EI; Pogorelov, AG; Pogorelova, VG | 1 |
| Lambert, PA; Smith, AR | 1 |
| Al-Helal, M; Biagini, GA; Bray, PG; Fisher, N; Lian, LY; Roslaini, AM; Ward, SA | 1 |
| Danis, P; Farkas, R | 1 |
| Bergold, PJ; Coplan, JD; Dow-Edwards, D; Fenton, AA; Jozwicka, A; Kao, HY; Pinkhasova, V; Syed, M; Zhao, N | 1 |
| Feron, O | 1 |
| Field, CR; Pierre, ZN; Scheeline, A | 1 |
| Brown, SA; Whiteley, M | 1 |
| Antonyuk, SV; Bessho, Y; Ellis, MJ; Hasnain, SS; Inoue, Y; Kuramitsu, S; Strange, RW; Yokoyama, S | 1 |
| Chen, J; Dong, Z; Liu, L; Qin, Y; Zhou, J | 1 |
| Clomburg, JM; Gonzalez, R; Murarka, A | 1 |
| Atlante, A; de Bari, L; Passarella, S; Valenti, D | 1 |
| Hegde, KR; Kovtun, S; Varma, SD | 1 |
| Dybala-Defratyka, A; Rohr, DR; Swiderek, K | 1 |
| Chieppa, G; De Bari, L; Marra, E; Passarella, S | 1 |
| Agrawal, R; Mohan, J; Moudgal, RP; Pandey, NK; Sastry, KV; Saxena, VK; Shit, N; Singh, KB; Singh, RP | 1 |
| Akhtar, MK; Jones, PR; Mizutani, T; Veit, A | 1 |
| Ananyev, G; Bennette, N; Bryant, DA; Dismukes, GC; McNeely, K; Xu, Y | 1 |
| Betti, L; Calvaresi, EC; Funel, N; Giacomelli, C; Giannaccini, G; Giovannetti, E; Granchi, C; Hergenrother, PJ; Lanza, M; León, LG; Lucacchini, A; Macchia, M; Martinelli, A; Minutolo, F; Palchaudhuri, R; Peters, GJ; Roy, S; Tuccinardi, T | 1 |
| Eddy, EM; Gabel, SA; Goldberg, E; London, RE; Odet, F; Williams, J | 1 |
| Engel, PC; Guyonvarch, A; Maher, MA; Sharkey, MA | 1 |
| Callender, R; Clinch, K; Deng, H; Desamero, R; Dyer, RB; Vu, DV | 1 |
| Borras, C; Gambini, J; Gomez-Cabrera, MC; Herranz, D; Lopez-Grueso, R; Martinez-Bello, VE; Pallardo, FV; Serrano, M; Tresguerres, JA; Valles, SL; Viña, J | 1 |
| Byrne, ME; Chambers, RP; Eggert, MW | 1 |
| Guo, HW; Wang, HW; Wei, YH | 1 |
| Galeffi, F; Sadgrove, MP; Shetty, PK; Turner, DA | 1 |
| Hu, Q; Jin, J; Loscalzo, J; Wang, X; Xu, L; Yang, Y; Yi, J; Yu, Z; Zhao, Y; Zhou, HM | 1 |
| Lee, YH; Musa, A; Tan, LL | 1 |
| Heinzle, E; Niklas, J; Nonnenmacher, Y; Rose, T; Sandig, V | 1 |
| Ojima, Y; Suryadarma, P; Taya, M; Tsuchida, K | 1 |
| Baliutyte, G; Baniene, R; Borutaite, V; Gendviliene, V; Martisiene, I; Toleikis, A; Trumbeckaite, S | 1 |
| Besser, S; Hirrlinger, J; Hirrlinger, PG; Requardt, RP; Wilhelm, F; Winkler, U | 1 |
| Do, PM; Govindasamy, L; Ingram, LO; Rhee, MS; Shanmugam, KT; Sun, Z; Wang, Q | 1 |
| Itoh, M; Kaneko, YS; Kondo, K; Mori, K; Nagasaki, H; Nagatsu, T; Nakashima, A; Ota, A; Ota, M; Takayanagi, T | 1 |
| Grieshaber, MK; Schmitt, L; Smits, SH; van Os, N | 1 |
| Chen, B; Lei, C; Liu, J; Tam, TK | 1 |
| Banniza, S; Bhadauria, V; Selvaraj, G; Vandenberg, A; Wei, Y | 1 |
| Makovšek, K; Vasić-Rački, Đ; Vrsalović Presečki, A | 1 |
| Cai, AL; Sheline, CT; Shi, C; Zhang, W; Zhu, J | 1 |
| Bhadhuri, G; Bhattacharya, B; Choudhuri, S; Chowdhury, IH; Dutta, D; Mandal, LK; Mukherjee, A; Paine, SK; Saha, A; Sen, A | 1 |
| Banerjee, N; Bhattacharyya, D | 1 |
| Mannowetz, N; Wandernoth, PM; Wennemuth, G | 1 |
| Corkey, BE; Shirihai, O | 1 |
| Hertz, L; Li, B; Peng, L | 1 |
| Cai, AL; Li, L; Sheline, CT; Sheline, PJ; Shi, C; Takata, T; Zhang, W; Zhu, J | 1 |
| Kerr, AB; Larson, PE; Pauly, JM; Swisher, CL; Vigneron, DB | 1 |
| Chorvat, D; Chorvatova, A; Elzwiei, F; Mateasik, A | 1 |
| Bai, S; Sheline, CT | 1 |
| Jacobs, RA; Lundby, C; Meinild, AK; Nordsborg, NB | 1 |
| Li, Y; Liang, H; Sun, L; Wu, J; Yuan, Q | 1 |
| Cotter, DG; Crawford, PA; d'Avignon, DA; Dietzen, DJ; Ercal, B | 1 |
| Kadokura, T; Kiyoshi, K; Kosugi, S; Kusumoto, K; Nakayama, S; Nakazato, A; Oba, T | 1 |
| Frick, L; Lamarr, W; Liu, Y; Thana, P; Turincio, R; Vanderporten, E | 1 |
| Behrens, C; Blume, C; Braun, HP; Eubel, H; Peterhansel, C | 1 |
| Honda, K; Morimoto, Y; Ohtake, H; Okano, K; Ye, X | 1 |
| Hung, YP; Yellen, G | 1 |
| Christensen, CE; Jensen, PR; Karlsson, M; Lerche, MH; Winther, JR | 1 |
| Agarwal, B; Bosnjak, ZJ; Camara, AK; Dash, RK; Stowe, DF | 1 |
| Callender, R; Deng, H; Dyer, RB; Peng, HL | 1 |
| Glasser, NR; Kern, SE; Newman, DK | 1 |
| Gao, X; Li, S; Liu, L; Xu, N | 1 |
| Dawson, NJ; Katzenback, BA; Storey, KB | 1 |
| Balcells, C; Cascante, M; Madurga, S; Mas, F; Pastor, I; Vilaseca, E | 1 |
| Estala, L; Ferrer, IM; Gomez, FA; Valadez, H | 1 |
| Fratto, BE; Guz, N; Katz, E; Roby, LJ | 1 |
| Cheng, YQ; Liu, HJ; Sima, YH; Tao, H; Xu, SQ; Yin, WM | 1 |
| Dubey, NC; Stamm, M; Tripathi, BP | 1 |
| Alvarez, CE; Andreo, CS; Drincovich, MF; Golic, A; Hogenhout, SA; Mussi, MA; Saigo, M | 1 |
| Chaumeil, MM; Gaensler, K; Ito, M; Jalbert, LE; Mukherjee, J; Nelson, SJ; Park, I; Pieper, RO; Ronen, SM | 1 |
| Grein, F; Keller, KL; Oliveira, GP; Pereira, IA; Ramos, AR; Venceslau, SS; Wall, JD | 1 |
| Gaviraghi, A; Oliveira, MF; Soares, JB | 1 |
| Inui, M; Suda, M; Tsuge, Y; Uematsu, K; Yamamoto, S; Yukawa, H | 1 |
| Pan, X; Schwartz, SD | 1 |
| Awasthi, V; Hedrick, AF; Hussain, A; Rao, G; Xie, J; Yadav, VR | 1 |
| Brooks, DM; Jaimes, R; Kay, MW; Kuzmiak-Glancy, S; Posnack, NG; Swift, LM | 1 |
| Awasthi, V; Hedrick, A; Rao, G; Xie, J | 1 |
| Heinzle, E; Nicolae, A; Nonnenmacher, Y; Wahrheit, J; Weyler, C | 1 |
| Ito, T; Jong, CJ; Schaffer, SW; Shimada-Takaura, K; Takahashi, K | 1 |
| Li, R; Luo, X; Yan, LJ | 1 |
| Ashruf, JF; Eerbeek, O; Eykyn, TR; Mariotti, E; Orton, MR; Southworth, R; Zuurbier, CJ | 1 |
| Carl, SM; Koppel, S; Michaelis, EK; Michaelis, ML; Ramanujan, S; Swerdlow, RH; Weidling, I; Wilkins, HM | 1 |
| Baronian, K; Bode, R; Kasprzak, J; Kunze, G; Rauter, M; Riechen, J; Schauer, F; Worch, S | 1 |
| Chen, S; He, D; Sang, N; Tan, X; Yin, C | 1 |
| Fang, B; Jiang, W; Lu, J; Sun, D; Wang, S; Zhang, Y | 1 |
| Chen, X; Dong, X; Liu, L; Qian, Y; Qiao, W; Wang, L; Wang, Y | 1 |
| Bush, LN; Davidson, SM; Freinkman, E; Gitego, N; Gui, DY; Hosios, AM; Luengo, A; Sullivan, LB; Thomas, CJ; Vander Heiden, MG | 1 |
| Fukiya, S; Iwabu, Y; Kato, R; Kihira, C; Maeda, S; Shimizu, K; Sugimoto, M; Wada, M; Yokota, A | 1 |
| Andreo, CS; Arias, CL; Badia, MB; Drincovich, MF; Gerrard Wheeler, MC; Lis, AV; Mans, R; Maurino, VG; Tronconi, MA; van Maris, AJ | 1 |
| Jiang, JF; Lei, F; Lu, X; Wang, XP; Xing, DM; Yan, XJ; Yu, X; Yuan, ZY | 1 |
| Stacpoole, PW | 1 |
| Fessel, JP; Oldham, WM | 1 |
| Bae, IH; Ham, M; Kil, IS; Kim, HJ; Kim, JY; Kim, KH; Lee, AY; Lee, SH; Lee, TR; Min, D; Shin, DW; Son, ED; Song, YW | 1 |
| Hua, D; Qin, J; Wang, A; Wang, X; Zhu, L | 1 |
| Beyrath, J; Iannetti, EF; Koopman, WJH; Smeitink, JAM; Willems, PHGM | 1 |
| Cox, BL; Eliceiri, KW; Erickson-Bhatt, S; Fain, SB; Ludwig, KD; Macdonald, EB; Ponik, SM; Squirrell, JM; Swader, R; Szulczewski, JM | 1 |
| He, L; Jia, Y; Li, J; Li, Y; Liao, C; Yang, D; Yu, C; Yu, Z; Zhang, C | 1 |
| Miller, CA; Radnai, L; Rumbaugh, G; Sellers, JR; Stremel, RF | 1 |
| Chen, Z; Hu, B; Li, S; Ma, R; Ma, W; Workman, JL; Wu, Y; Yang, W; Yu, Q; Yu, X; Zhai, Y | 1 |
| Torkzadeh-Mahani, M; Zaboli, M | 1 |
| Hamacek, J; Matić, M; Piazza, F; Saurabh, S | 1 |
| Goodman, RP; Ichinose, F; Marutani, E; Miyazaki, Y; Mootha, VK; Patgiri, A; Robert Bao, X; Schleifer, G; Shah, H; Sharma, R; Skinner, OS; To, TL; Zapol, WM | 1 |
| Chen, J; Chen, X; Gao, W; Hao, B; Huang, M; Huang, W; Li, K; Liu, J; Liu, Q; Liu, R; Shao, Y; Wang, J; Wang, Q; Wei, Z; Xu, P; Xu, Y; Ye, S; Zeng, S; Zhang, H; Zhang, Q; Zhong, Z | 1 |
| Cheng, WH; Chiu, CH; Huang, KY; Huang, PJ; Ku, FM; Lee, CC; Lin, R; Ong, SC; Tang, P; Yeh, YM | 1 |
| Chandel, NS | 1 |
| Le, XH; Lee, CP; Millar, AH | 1 |
| Bulygin, KV; Galimov, KS; Galimov, SN; Galimova, EF; Gromenko, JY; Sinelnikov, MY | 1 |
| Benfdil, M; Bouchard, J; Bourdeau, V; Ferbeyre, G; Fernandez-Ruiz, A; Fouillen, A; Gagnon, E; Guillon, J; Hulea, L; Huot, G; Igelmann, S; Kalegari, P; Kenner, L; Lessard, F; Lopes-Paciencia, S; Mignacca, L; Moriggl, R; Nanci, A; Omichinski, JG; Papadopoli, D; Pencik, J; Pollak, MN; Ponce, KJ; Quenneville, J; Rowell, MC; Topisirovic, I; Uchenunu, O; Vuong, N; Wahba, HM | 1 |
| Abramov, AY; Berezhnov, AV; Dolgacheva, LP; Fedotova, EI | 1 |
| Abiko, Y; Kobayashi, Y; Liu, S; Otani, H; Sasaki, S; Sato, S; Shinohara, Y; Takahashi, N; Wang, X; Washio, J | 1 |
| Baffert, C; Brugna, M; Denis, Y; Guendon, C; Kpebe, A; Lebrun, R; Payne, N; Ros, J; Shintu, L | 1 |
| Belovich, JM; Chalhoub, ER | 1 |
| Bajpai, S; Banerjee, S; Kumar, A; Kushwaha, R; Saha, S; Yadav, AK | 1 |
| Barger, C; Batsios, G; Costello, JF; Gillespie, AM; Ronen, SM; Stevers, N; Taglang, C; Tran, M; Viswanath, P | 1 |
| Le, XH; Lee, CP; Millar, AH; Monachello, D | 1 |
| Adant, I; Bird, M; Cassiman, D; de Witte, P; Decru, B; Ghesquière, B; Rymen, D; Vermeersch, P; Wallays, M; Windmolders, P; Witters, P | 1 |
| Ackenhusen, SE; Andren, A; Chen, B; Crawford, HC; Galban, S; Gao, X; Halbrook, CJ; Hoffman, MT; Jiménez, JA; Kemp, SB; Kerk, SA; Lin, L; Lombard, DB; Long, D; Lyssiotis, CA; Myers, AL; Nelson, BS; Nwosu, ZC; Pasca di Magliano, M; Piwnica-Worms, DR; Ramos, J; Robinson, A; Sajjakulnukit, P; Shah, YM; Steele, NG; Sutton, DJ; Thurston, G; Wen, HJ; Ying, H; Zhang, L; Zhang, Y | 1 |
| Aamer, E; Baune, M; Bösing, I; Dringen, R; Reimer, N; Romero, M; Thöming, J | 1 |
| Cardaci, S; Eberhart, T; Mainini, F; Ricci, L; Stanley, FU; Sumpton, D | 1 |
| Bruggeman, C; Gregurash, K; Hickey, DP | 1 |
| Afzal, AR; Jeon, J; Jung, CH | 1 |
| Choi, YS; Kim, CH; Kim, E; Lee, JE; Song, HT; Song, JE | 1 |
14 review(s) available for pyruvic acid and nad
| Article | Year |
|---|---|
Disorders of the pyruvate dehydrogenase complex.
Topics: Acetyl Coenzyme A; Acetyltransferases; Acidosis; Brain; Carbon Dioxide; Child; Child, Preschool; Coenzyme A; Cranial Nerves; Dihydrolipoamide Dehydrogenase; Dihydrolipoyllysine-Residue Acetyltransferase; Facial Bones; Feedback; Humans; Lactates; Lactic Acid; Leigh Disease; Molecular Weight; Movement Disorders; NAD; Nervous System Diseases; Phosphoric Monoester Hydrolases; Pyruvate Decarboxylase; Pyruvate Dehydrogenase Complex; Pyruvate Dehydrogenase Complex Deficiency Disease; Pyruvates; Pyruvic Acid; Spectrophotometry | 1986 |
An evaluation of biochemical aspects of intravenous fructose, sorbitol and xylitol administration in man.
Topics: Acid-Base Equilibrium; Adenosine Triphosphate; Biological Transport; Blood Glucose; Energy Metabolism; Fructose; Glucose; Glycogen; Humans; Infusions, Parenteral; Insulin; Insulin Secretion; Lactates; Lactic Acid; NAD; Phosphorylation; Pyruvates; Pyruvic Acid; Sorbitol; Triglycerides; Xylitol | 1985 |
[Basis of enzyme activity determination].
Topics: Buffers; Enzymes; Humans; Hydrogen-Ion Concentration; Isoenzymes; L-Lactate Dehydrogenase; Methods; NAD; Pyruvates; Pyruvic Acid; Quality Control; Reference Values; Temperature; Time Factors | 1983 |
Mechanism of coupled electron and group transfer in Escherichia coli pyruvate dehydrogenase.
Topics: Acetyl Coenzyme A; Acetylation; Binding Sites; Chemical Phenomena; Chemistry; Coenzyme A; Electron Transport; Escherichia coli; Flavin-Adenine Dinucleotide; Molecular Weight; NAD; Oxidation-Reduction; Pyruvate Dehydrogenase Complex; Pyruvates; Pyruvic Acid; Spectrophotometry; Thiamine Pyrophosphate; Thioctic Acid | 1982 |
Regulation of energy source metabolism in streptococci.
Topics: Adaptation, Biological; Citric Acid; Energy Metabolism; Fermentation; Glucose; NAD; Pyruvic Acid; Streptococcaceae | 1997 |
What couples glycolysis to mitochondrial signal generation in glucose-stimulated insulin secretion?
Topics: Adenosine Triphosphate; Animals; Carrier Proteins; Cell Line; Cells, Cultured; Glucose; Glutamic Acid; Glycolysis; Humans; Insulin; Insulin Secretion; L-Lactate Dehydrogenase; Mice; Mitochondria; Models, Biological; Monocarboxylic Acid Transporters; NAD; Pyruvic Acid; Rats; Signal Transduction | 2000 |
Carbohydrate and energy-yielding metabolism in non-conventional yeasts.
Topics: Carbohydrate Metabolism; Citric Acid Cycle; Disaccharides; Energy Metabolism; Ethanol; Fermentation; Fungal Proteins; Glycerol; Glycolysis; Hexoses; NAD; Oxygen Consumption; Pentosephosphates; Pyruvate Decarboxylase; Pyruvate Dehydrogenase Complex; Pyruvic Acid; Yeasts | 2000 |
In beta-cells, mitochondria integrate and generate metabolic signals controlling insulin secretion.
Topics: Adenosine Triphosphate; Animals; Diabetes Mellitus, Type 2; Electron Transport Chain Complex Proteins; Exocytosis; Glutamate Dehydrogenase; Humans; Insulin; Insulin Secretion; Insulin-Secreting Cells; Mitochondria; NAD; Pyruvic Acid; Signal Transduction | 2006 |
Hormone-dependent and hormone-independent control of metabolic and developmental functions of malate dehydrogenase - review.
Topics: Animals; Cell Differentiation; Cell Division; Disease; Growth; Homeostasis; Hormones; Humans; Malate Dehydrogenase; NAD; NADP; Pyruvic Acid | 2009 |
Pyruvate into lactate and back: from the Warburg effect to symbiotic energy fuel exchange in cancer cells.
Topics: Cell Death; Cell Hypoxia; Cell Line, Tumor; Cell Survival; Energy Metabolism; Glycolysis; Humans; Lactic Acid; NAD; NADP; Neoplasms; Oxidation-Reduction; Pyruvic Acid; Radiation Tolerance; Sensitivity and Specificity | 2009 |
Roles of Pyruvate, NADH, and Mitochondrial Complex I in Redox Balance and Imbalance in β Cell Function and Dysfunction.
Topics: Animals; Blood Glucose; Diabetes Mellitus; Electron Transport Complex I; Glucose; Humans; Insulin; Insulin Secretion; Insulin-Secreting Cells; Mitochondria; NAD; Oxidation-Reduction; Oxidative Stress; Pyruvic Acid; Reactive Oxygen Species | 2015 |
Therapeutic Targeting of the Pyruvate Dehydrogenase Complex/Pyruvate Dehydrogenase Kinase (PDC/PDK) Axis in Cancer.
Topics: Acetyl Coenzyme A; Adenosine Triphosphate; Biomimetics; Citric Acid Cycle; Dichloroacetic Acid; Energy Metabolism; Glycolysis; Humans; Isoenzymes; Mitochondria; NAD; Neoplasms; Oxidative Phosphorylation; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Pyruvate Dehydrogenase Complex; Pyruvic Acid | 2017 |
Glycolysis.
Topics: Adenosine Triphosphate; Aerobiosis; Animals; Glycolysis; Humans; NAD; Pyruvic Acid; Warburg Effect, Oncologic | 2021 |
Os(II) complexes for catalytic anticancer therapy: recent update.
Topics: Antineoplastic Agents; Catalysis; Coordination Complexes; Humans; NAD; Pyruvic Acid; Reactive Oxygen Species | 2022 |
1 trial(s) available for pyruvic acid and nad
| Article | Year |
|---|---|
Xylitol-induced increase in the concentration of oxypurines and its mechanism.
Topics: Administration, Oral; Adult; Chromatography, High Pressure Liquid; Cytosol; Humans; Hypoxanthine; Hypoxanthines; Infusions, Intravenous; Inosine; Intestine, Small; Lactates; Lactic Acid; Liver; Male; Middle Aged; NAD; Phosphates; Pyrazinamide; Pyruvates; Pyruvic Acid; Saline Solution, Hypertonic; Serum Albumin; Uric Acid; Xanthine; Xanthine Dehydrogenase; Xanthines; Xylitol | 1995 |
416 other study(ies) available for pyruvic acid and nad
| Article | Year |
|---|---|
Reducing-equivalent transfer to the mitochondria during gluconeogenesis and ureogenesis in hepatocytes from rats of different thyroid status.
Topics: Alanine; Animals; Aspartic Acid; Biological Transport; Cells, Cultured; Cytoplasm; Gluconeogenesis; Glutamates; Glutamic Acid; Hydrogen; Hyperthyroidism; Hypothyroidism; Male; Malonates; Mitochondria, Liver; NAD; Pyruvates; Pyruvic Acid; Rats; Rats, Wistar; Thyroid Gland; Urea | 1992 |
Intracellular pH and the role of D-lactate dehydrogenase in the production of metabolic end products by Leuconostoc lactis.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Enzyme Activation; Guanosine Triphosphate; Hydrogen-Ion Concentration; Kinetics; L-Lactate Dehydrogenase; Leuconostoc; NAD; Pyruvates; Pyruvic Acid | 1992 |
Oxidative modification of lactate dehydrogenase by a non-enzymatic metal ion-catalyzed oxidation system.
Topics: Animals; Ascorbic Acid; Catalysis; Edetic Acid; Electrophoresis, Polyacrylamide Gel; Free Radical Scavengers; Humans; Iron; L-Lactate Dehydrogenase; NAD; Oxidation-Reduction; Oxygen; Pyruvates; Pyruvic Acid; Rabbits | 1992 |
Postanoxic oxidative injury in rat hepatocytes: lactate-dependent protection against tert-butylhydroperoxide.
Topics: Animals; Free Radicals; Hypoxia; L-Lactate Dehydrogenase; Lactates; Lactic Acid; Liver; Male; NAD; Oxidants; Peroxides; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains; tert-Butylhydroperoxide | 1992 |
Primary structure, physicochemical properties, and chemical modification of NAD(+)-dependent D-lactate dehydrogenase. Evidence for the presence of Arg-235, His-303, Tyr-101, and Trp-19 at or near the active site.
Topics: Amino Acid Sequence; Amino Acids; Base Sequence; Binding Sites; Blotting, Western; Chromatography, High Pressure Liquid; Electrophoresis, Polyacrylamide Gel; Hydrogen-Ion Concentration; Isoelectric Focusing; Kinetics; L-Lactate Dehydrogenase; Lactobacillus; Molecular Sequence Data; NAD; Oxidation-Reduction; Polymerase Chain Reaction; Pyruvates; Pyruvic Acid; Substrate Specificity | 1992 |
Effects of congenital hyperammonemia on the cerebral and hepatic levels of the intermediates of energy metabolism in spf mice.
Topics: Adenosine Triphosphate; Ammonia; Animals; Brain; Coenzyme A; Energy Metabolism; Glucose; Glutamine; Ketoglutaric Acids; Liver; Mice; Mice, Mutant Strains; NAD; Ornithine Carbamoyltransferase; Ornithine Carbamoyltransferase Deficiency Disease; Oxidation-Reduction; Pyruvates; Pyruvic Acid; X Chromosome | 1992 |
Free and membrane-bound lactate dehydrogenase from white driving muscles of skate.
Topics: Animals; Hydrogen-Ion Concentration; Kinetics; L-Lactate Dehydrogenase; Membranes; Muscles; NAD; Pyruvates; Pyruvic Acid; Skates, Fish; Solubility; Substrate Specificity | 1992 |
Isolation, characterization, and physiological role of the pyruvate dehydrogenase complex and alpha-acetolactate synthase of Lactococcus lactis subsp. lactis bv. diacetylactis.
Topics: Acetolactate Synthase; Cations, Divalent; Chromatography, High Pressure Liquid; Kinetics; Lactococcus lactis; NAD; Pyruvate Dehydrogenase Complex; Pyruvates; Pyruvic Acid; Thiamine Pyrophosphate | 1992 |
Kinetic comparison of caiman epsilon-crystallin and authentic lactate dehydrogenases of vertebrates.
Topics: Alligators and Crocodiles; Animals; Chickens; Crystallins; Ducks; Electrophoresis, Polyacrylamide Gel; Isoenzymes; Kinetics; L-Lactate Dehydrogenase; Lactates; Lactic Acid; Lens, Crystalline; Muscles; Myocardium; NAD; Nitroblue Tetrazolium; Pyruvates; Pyruvic Acid; Staining and Labeling; Swine | 1991 |
Role of endogenous fatty acids in the control of hepatic gluconeogenesis.
Topics: 3-Hydroxybutyric Acid; Animals; Epoxy Compounds; Fatty Acids; Fatty Acids, Volatile; Gluconeogenesis; Hydroxybutyrates; Liver; Male; NAD; Oxidation-Reduction; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains | 1992 |
Distribution of control of oxidative phosphorylation in mitochondria oxidizing NAD-linked substrates.
Topics: Animals; Kidney; Kinetics; Membrane Potentials; Mitochondria, Heart; NAD; Oxidative Phosphorylation; Oxidoreductases; Phenazines; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains; Substrate Specificity | 1991 |
Multi-enzyme catalyzed rapid ethanol lowering in vitro.
Topics: Acetaldehyde; Acetates; Alcohol Dehydrogenase; Aldehyde Dehydrogenase; Animals; Dogs; Duodenum; Ethanol; Gastrointestinal Contents; L-Lactate Dehydrogenase; NAD; Pyruvates; Pyruvic Acid | 1991 |
Intramitochondrial fatty acid activation enhances control strength of adenine nucleotide translocase.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Caprylates; Female; Hydrogen; Mitochondria, Liver; Mitochondrial ADP, ATP Translocases; NAD; Oxygen Consumption; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains | 1991 |
Regulation of glycolysis in the erythrocyte: role of the lactate/pyruvate and NAD/NADH ratios.
Topics: Adult; Erythrocytes; Glycolysis; Humans; Lactates; Lactic Acid; NAD; Pyruvates; Pyruvic Acid | 1991 |
Kinetic mechanism of the endogenous lactate dehydrogenase activity of duck epsilon-crystallin.
Topics: Animals; Binding, Competitive; Coenzymes; Crystallins; Ducks; Heart; Kinetics; L-Lactate Dehydrogenase; Lactates; Lactic Acid; Myocardium; NAD; Oxamic Acid; Pyruvates; Pyruvic Acid; Substrate Specificity; Tartronates | 1991 |
Stimulation of alanine metabolism by ammonia in the perfused rat liver. Quantitative analysis by means of a mathematical model.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Alanine; Ammonium Chloride; Animals; Caprylates; Energy Metabolism; Female; Gluconeogenesis; Glucose; Hydroxybutyrates; Kinetics; Lactates; Lactic Acid; Liver; Mathematics; Models, Biological; NAD; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains; Urea | 1991 |
Lactate dehydrogenase from gastrocnemius muscle of turtle.
Topics: Animals; Chromatography, Affinity; Chromatography, Gel; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Isoenzymes; L-Lactate Dehydrogenase; Lactates; Lactic Acid; Muscles; NAD; Oxalates; Oxalic Acid; Pyruvates; Pyruvic Acid; Substrate Specificity; Temperature; Turtles | 1990 |
Involvement of pyruvate dehydrogenase in product formation in pyruvate-limited anaerobic chemostat cultures of Enterococcus faecalis NCTC 775.
Topics: Acetyltransferases; Anaerobiosis; Enterococcus faecalis; Fermentation; Hydrogen-Ion Concentration; L-Lactate Dehydrogenase; NAD; Oxidation-Reduction; Pyruvate Dehydrogenase Complex; Pyruvates; Pyruvic Acid | 1990 |
Menadione partially restores NADH-oxidation and ATP-synthesis in complex I deficient fibroblasts.
Topics: Adenosine Triphosphate; Cells, Cultured; Fibroblasts; Glucose; Humans; Lactates; Lactic Acid; NAD; NAD(P)H Dehydrogenase (Quinone); Oxidation-Reduction; Pyruvates; Pyruvic Acid; Quinone Reductases; Rotenone; Vitamin K | 1990 |
Development and regulation of hepatocellular fatty acid synthesis towards term: studies in isolated fetal rat hepatocytes.
Topics: Animals; Caprylates; Cyclic AMP; Fatty Acids; Female; Insulin; Lactates; Lactic Acid; Liver; NAD; NADP; Pregnancy; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains | 1990 |
NADH-linked substrate dependence of peroxide-induced respiratory inhibition and calcium efflux in isolated renal mitochondria.
Topics: 3-Hydroxybutyric Acid; Animals; Calcium; Glutamates; Hydroxybutyrates; In Vitro Techniques; Kidney; Mitochondria; NAD; NADP; Peroxides; Pyruvate Dehydrogenase Complex; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains; Reperfusion Injury | 1990 |
The monocarboxylate carrier from rat liver mitochondria. Purification and kinetic characterization in a reconstituted system.
Topics: Acetoacetates; Animals; Biological Transport; Carrier Proteins; Coumaric Acids; Kinetics; L-Lactate Dehydrogenase; Liposomes; Mitochondria, Liver; Molecular Weight; Monocarboxylic Acid Transporters; NAD; Pyruvates; Pyruvic Acid; Rats; Spectrophotometry | 1990 |
Kinetic analysis of duck epsilon-crystallin, a lens structural protein with lactate dehydrogenase activity.
Topics: Animals; Chickens; Chromatography, Ion Exchange; Crystallins; Drug Stability; Ducks; Hot Temperature; Kinetics; L-Lactate Dehydrogenase; Lactates; Lactic Acid; Lens, Crystalline; Muscles; Myocardium; NAD; Pyruvates; Pyruvic Acid | 1990 |
Comparison of different flow injection approaches to the automatic determination of enzymatic activity.
Topics: Enzymes; Hydrogen-Ion Concentration; Indicators and Reagents; L-Lactate Dehydrogenase; Lactates; Lactic Acid; NAD; Pyruvates; Pyruvic Acid; Spectrophotometry, Ultraviolet; Temperature | 1989 |
alpha-Glycerophosphate shuttle in a clonal beta-cell line.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Amobarbital; Cell Line; Clone Cells; Cytosol; Electron Transport; Glucose; Glycerolphosphate Dehydrogenase; Glycerophosphates; Glycolysis; Guanosine Diphosphate; Guanosine Triphosphate; Insulin; Insulin Secretion; Islets of Langerhans; Lactates; Lactic Acid; NAD; Oxidation-Reduction; Oxygen Consumption; Pyruvates; Pyruvic Acid | 1989 |
Structure and properties of malic enzyme from Bacillus stearothermophilus.
Topics: Amino Acid Sequence; Base Sequence; Cations, Divalent; Cloning, Molecular; Codon; DNA, Bacterial; Escherichia coli; Geobacillus stearothermophilus; Hydrogen-Ion Concentration; Kinetics; Macromolecular Substances; Malate Dehydrogenase; Malates; Molecular Sequence Data; NAD; NADP; Oxaloacetates; Promoter Regions, Genetic; Pyruvates; Pyruvic Acid; Temperature | 1989 |
Lactate dehydrogenase displays absolute stereospecificity in the transfer of the prochiral hydrogen of NADH.
Topics: Animals; Deuterium; Hydrogen; Kinetics; L-Lactate Dehydrogenase; Lactates; Lactic Acid; Myocardium; NAD; Oxidation-Reduction; Pyruvates; Pyruvic Acid; Radioisotope Dilution Technique; Stereoisomerism; Swine; Tritium | 1989 |
Calcium uptake by bovine epididymal spermatozoa is regulated by the redox state of the mitochondrial pyridine nucleotides.
Topics: 3-Hydroxybutyric Acid; Adenosine Triphosphate; Animals; Ascorbic Acid; Butyrates; Butyric Acid; Calcium; Caproates; Cattle; Digitonin; Epididymis; Hydroxybutyrates; Lactates; Lactic Acid; Male; Mitochondria; NAD; Oxidation-Reduction; Pentanoic Acids; Pyruvates; Pyruvic Acid; Rotenone; Spermatozoa; Tetramethylphenylenediamine | 1989 |
Oxidation of cytosolic NADH by the malate-aspartate shuttle in MC29 hepatoma cells.
Topics: Aminooxyacetic Acid; Animals; Aspartic Acid; Chickens; Cytosol; Glutamine; Lactates; Lactic Acid; Liver Neoplasms, Experimental; Malates; Mitochondria; NAD; Oxidation-Reduction; Pyruvates; Pyruvic Acid | 1989 |
Regulation of lactate/pyruvate ratios by cyclic AMP in Neurospora crassa.
Topics: Adenylyl Cyclases; Chromatography, High Pressure Liquid; Cyclic AMP; Glycolysis; L-Lactate Dehydrogenase; Lactates; Lactic Acid; Mutation; NAD; Neurospora; Neurospora crassa; Pyruvates; Pyruvic Acid | 1988 |
Protein ligand interactions. Indole alkaloids as inhibitors for lactate dehydrogenase.
Topics: Animals; Binding, Competitive; Kinetics; L-Lactate Dehydrogenase; NAD; Protein Binding; Pyruvates; Pyruvic Acid; Structure-Activity Relationship; Strychnine; Substrate Specificity | 1987 |
Changes in pyridine nucleotide levels alter oxygen consumption and extra-mitochondrial phosphates in isolated mitochondria: a 31P-NMR and NAD(P)H fluorescence study.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Fluorescent Dyes; Glutamates; Glutamic Acid; Magnetic Resonance Spectroscopy; Malates; Male; Mitochondria, Liver; NAD; NADP; Oxygen Consumption; Phosphates; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains; Rhodamines; Spectrometry, Fluorescence | 1987 |
Regulation of mitochondrial adenine nucleotide content in newborn rabbit liver.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adenine Nucleotides; Adrenergic beta-Agonists; Animals; Animals, Newborn; Bucladesine; Cytosol; Glucagon; Glucose; Hydroxybutyrates; Insulin; Isoproterenol; Kinetics; Lactates; Lactic Acid; Mitochondria, Liver; NAD; Oxidation-Reduction; Oxygen; Pyruvates; Pyruvic Acid; Rabbits | 1987 |
Carbohydrate interconversions and energy production.
Topics: Biological Transport, Active; Carbohydrate Metabolism; Citric Acid Cycle; Energy Metabolism; Glucose; Glyceraldehyde-3-Phosphate Dehydrogenases; Glycogen; Glycogen Synthase; Glycolysis; Hexokinase; Humans; Mitochondria, Heart; Myocardium; NAD; Phosphofructokinase-1; Phosphorylase Kinase; Phosphorylation; Protein Kinases; Pyruvates; Pyruvic Acid | 1985 |
Neurospora crassa pyruvate dehydrogenase complex: component characterization, catalytic properties and location of translation.
Topics: Calcium; Chloramphenicol; Coenzyme A; Cycloheximide; Electrophoresis, Polyacrylamide Gel; Ethylmaleimide; Kinetics; Magnesium; Mitochondria; Molecular Weight; NAD; Neurospora; Neurospora crassa; Protein Biosynthesis; Pyruvate Dehydrogenase Complex; Pyruvates; Pyruvic Acid | 1988 |
Cyclic GMP affects redox state and improves energy charge of ischaemic Langendorff-perfused rat heart.
Topics: Animals; Coronary Disease; Cyclic GMP; Energy Metabolism; Glucose; In Vitro Techniques; Lactates; Lactic Acid; Male; Myocardium; NAD; Oxidation-Reduction; Perfusion; Pyruvate Dehydrogenase Complex; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains | 1985 |
Catecholamine and vasopressin stimulation of gluconeogenesis from dihydroxyacetone in the presence of atractyloside.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Atractyloside; Bucladesine; Calcium; Cytosol; Dihydroxyacetone; Fructosediphosphates; Glucagon; Gluconeogenesis; Glycosides; Hydroxybutyrates; Lactates; Lactic Acid; Liver; Male; Mitochondria, Liver; NAD; Norepinephrine; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains; Trioses; Vasopressins | 1985 |
Respiratory chain defects in the mitochondria of cultured skin fibroblasts from three patients with lacticacidemia.
Topics: Adenosine Triphosphate; Cells, Cultured; Electron Transport Complex IV; Fibroblasts; Humans; Infant, Newborn; Lactates; Lactic Acid; Male; Mitochondria; NAD; NAD(P)H Dehydrogenase (Quinone); NADPH-Ferrihemoprotein Reductase; Oxygen Consumption; Pyruvates; Pyruvic Acid; Quinone Reductases; Skin | 1986 |
The interdependence of glycolytic and pentose cycle intermediates in ad libitum fed rats.
Topics: Animals; Gluconates; Glycolysis; Kinetics; Liver; Male; Mathematics; NAD; NADP; Oxidation-Reduction; Pentose Phosphate Pathway; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains; Ribose | 1986 |
Substrate utilization for lactate and energy production by heat-shocked L929 cells.
Topics: Adenosine Triphosphate; Animals; Carbon Dioxide; Cell Line; Citric Acid Cycle; Energy Metabolism; Fibroblasts; Glucose; Glutamine; Heat-Shock Proteins; Lactates; Lactic Acid; Mice; NAD; Oxidative Phosphorylation; Oxygen Consumption; Pyruvates; Pyruvic Acid; Temperature | 1986 |
Purification and characterization of pyruvate:NADP+ oxidoreductase in Euglena gracilis.
Topics: Acetyl Coenzyme A; Animals; Carbon Dioxide; Coenzyme A; Euglena gracilis; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Ketone Oxidoreductases; Molecular Weight; NAD; NADP; Pyruvates; Pyruvic Acid | 1987 |
Gluconeogenesis from serine in rabbit hepatocytes.
Topics: Animals; Cells, Cultured; Gluconeogenesis; Lactates; Lactic Acid; Liver; Male; NAD; Pyruvates; Pyruvic Acid; Rabbits; Serine; Urea | 1987 |
Effect of a deficiency of thiamine on brain pyruvate dehydrogenase: enzyme assay by three different methods.
Topics: Animals; Brain; Carbon Dioxide; Coloring Agents; Enzyme Activation; Kinetics; Male; Mitochondria; NAD; Oxidation-Reduction; Pyrithiamine; Pyruvate Dehydrogenase Complex; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains; Tetrazolium Salts; Thiamine Deficiency; Thiamine Pyrophosphate | 1988 |
Phosphorylation of lactate dehydrogenase by ATP.
Topics: Adenosine Triphosphate; Chemical Phenomena; Chemistry; Chromatography, Thin Layer; Enzyme Stability; Kinetics; L-Lactate Dehydrogenase; NAD; Phosphorylation; Pyruvates; Pyruvic Acid | 1988 |
On the mechanism of the so-called uncoupling effect of medium- and short-chain fatty acids.
Topics: Acetates; Adenine Nucleotides; Animals; Butyrates; Butyric Acid; Caprylates; Fatty Acids; Fatty Acids, Volatile; Female; Ketoglutaric Acids; Male; Membrane Potentials; Mitochondria, Liver; NAD; Oligomycins; Oxygen Consumption; Phosphates; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains; Rotenone; Succinates; Succinic Acid | 1988 |
Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), cyperquat (MPP+) and paraquat on isolated mitochondria from rat striatum, cortex and liver.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Adenosine Diphosphate; Animals; Cerebral Cortex; Corpus Striatum; Flavin-Adenine Dinucleotide; Malates; Mitochondria; Mitochondria, Liver; NAD; Oxidation-Reduction; Oxidative Phosphorylation; Oxygen Consumption; Paraquat; Phosphorylation; Pyridines; Pyridinium Compounds; Pyruvates; Pyruvic Acid; Rats; Succinates; Succinic Acid | 1988 |
[Congenital lactic acidemia].
Topics: Acidosis, Lactic; Biological Transport; Energy Metabolism; Humans; Mitochondria; NAD; Pyruvate Dehydrogenase Complex Deficiency Disease; Pyruvates; Pyruvic Acid | 1988 |
Stimulation by D-glucose of mitochondrial oxidative events in islet cells.
Topics: Acetyl Coenzyme A; Amino Acids; Animals; Cell Line; Glucose; Islets of Langerhans; Mitochondria; NAD; Oxidation-Reduction; Pyruvates; Pyruvic Acid; Rats; Stimulation, Chemical | 1987 |
An improved flow injection method for determination of lactate during exercise studies.
Topics: Autoanalysis; Fluorometry; Humans; L-Lactate Dehydrogenase; Lactates; NAD; Physical Exertion; Pyruvates; Pyruvic Acid | 1988 |
Native fluorescence of platelets from patients with occlusive arterial disease.
Topics: Arterial Occlusive Diseases; Blood Platelets; Humans; L-Lactate Dehydrogenase; NAD; Oxidation-Reduction; Pyruvates; Pyruvic Acid; Spectrometry, Fluorescence | 1988 |
Brain levels of NADH and NAD+ under hypoxic and hypoglycaemic conditions in vitro.
Topics: Adenosine Triphosphate; Animals; Brain; Female; Glucose; Guinea Pigs; Hypoglycemia; Hypoxia, Brain; In Vitro Techniques; Lactates; Lactic Acid; NAD; Oxidation-Reduction; Oxygen; Phosphocreatine; Pyruvates; Pyruvic Acid | 1988 |
Respiratory and metabolic responses of fetal and neonatal perfused livers to catecholamines and anoxia.
Topics: Animals; Animals, Newborn; Female; Gluconeogenesis; Glycolysis; Guinea Pigs; In Vitro Techniques; Lactates; Lactic Acid; Liver; NAD; Norepinephrine; Oxidation-Reduction; Oxygen Consumption; Perfusion; Pregnancy; Pyruvates; Pyruvic Acid | 1988 |
Rate determining factors of ethanol oxidation in hepatocytes from starved and fed rats: effect of acetaldehyde concentration on the rate of NADH oxidation catalyzed by alcohol dehydrogenase.
Topics: Acetaldehyde; Alcohol Dehydrogenase; Animals; Cyanamide; Ethanol; Female; Fructose; L-Lactate Dehydrogenase; Liver; NAD; Oxidation-Reduction; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains | 1987 |
Studies on the neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: inhibition of NAD-linked substrate oxidation by its metabolite, 1-methyl-4-phenylpyridinium.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Adenosine Diphosphate; Amino Acids; Animals; Brain; Corpus Striatum; Malates; Male; Mice; Mitochondria; NAD; Oxidation-Reduction; Oxygen Consumption; Pyridines; Pyridinium Compounds; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains | 1986 |
Short-term changes in blood ketone body ratio in the phase immediately after liver transplantation.
Topics: Animals; Female; Ketone Bodies; Lactates; Lactic Acid; Liver; Liver Transplantation; Male; Mitochondria, Liver; NAD; Postoperative Period; Preservation, Biological; Pyruvates; Pyruvic Acid; Swine; Tissue Preservation | 1987 |
A single amino acid substitution deregulates a bacterial lactate dehydrogenase and stabilizes its tetrameric structure.
Topics: Allosteric Regulation; Allosteric Site; Arginine; Bacterial Proteins; Binding Sites; Fructosediphosphates; Geobacillus stearothermophilus; Glutamine; L-Lactate Dehydrogenase; Mutation; NAD; Protein Binding; Protein Conformation; Pyruvates; Pyruvic Acid | 1987 |
The catalytic requirements for reduction and acetylation of protein X and the related regulation of various forms of resolved pyruvate dehydrogenase kinase.
Topics: Acetylation; Adenosine Diphosphate; Alkylation; Animals; Kidney; Kinetics; Macromolecular Substances; NAD; Oxidation-Reduction; Phenylmercury Compounds; Protein Kinases; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Pyruvates; Pyruvic Acid | 1987 |
2-Oxoglutarate dehydrogenase and pyruvate dehydrogenase activities in plant mitochondria: interaction via a common coenzyme a pool.
Topics: Acetyl Coenzyme A; Coenzyme A; Ketoglutarate Dehydrogenase Complex; Ketoglutaric Acids; Ketone Oxidoreductases; Mitochondria; NAD; Oxaloacetates; Oxidation-Reduction; Oxygen Consumption; Plants; Pyruvate Dehydrogenase Complex; Pyruvates; Pyruvic Acid | 1987 |
Acute responses of blood ketone body ratio following devascularization and revascularization of rabbit liver.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adenine Nucleotides; Animals; Energy Metabolism; Hydroxybutyrates; Ketone Bodies; Lactates; Lactic Acid; Liver; Liver Circulation; Male; Mitochondria, Liver; NAD; Pyruvates; Pyruvic Acid; Rabbits | 1987 |
Redox state and lactate accumulation in human skeletal muscle during dynamic exercise.
Topics: Adenine Nucleotides; Adult; Cytosol; Glycerophosphates; Glycolysis; Humans; Lactates; Lactic Acid; Male; Muscles; NAD; Oxidation-Reduction; Physical Exertion; Pyruvates; Pyruvic Acid | 1987 |
[Relation between the thermostability of the tetrameric molecule of lactate dehydrogenase from swine muscles and the degree of occupancy of its active sites with ligands].
Topics: Animals; Binding Sites; Calorimetry, Differential Scanning; Enzyme Stability; Hot Temperature; L-Lactate Dehydrogenase; Ligands; Macromolecular Substances; Muscles; NAD; Protein Conformation; Protein Denaturation; Pyruvates; Pyruvic Acid; Swine | 1987 |
Stimulatory effect of ADP, ATP, NAD(P) on pyruvate production from malate by uncoupled human placental mitochondria.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Female; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Malate Dehydrogenase; Malates; Mitochondria; NAD; Placenta; Pregnancy; Pyruvates; Pyruvic Acid | 1987 |
Hepatic UDP-glucuronic acid regulation during acetaminophen biotransformation in rats.
Topics: Acetaminophen; Animals; Biotransformation; Hydrogen-Ion Concentration; Kinetics; Lactates; Lactic Acid; Liver; Liver Glycogen; Male; NAD; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains; Salicylamides; Uridine Diphosphate Glucose; Uridine Diphosphate Glucose Dehydrogenase; Uridine Diphosphate Glucuronic Acid; Uridine Diphosphate Sugars | 1986 |
A 1H-NMR study of the activity expressed by lactate dehydrogenase in the human erythrocyte.
Topics: Erythrocytes; Glycylglycine; Humans; Imidazoles; L-Lactate Dehydrogenase; Lactates; Lactic Acid; Magnetic Resonance Spectroscopy; NAD; Pyruvates; Pyruvic Acid | 1986 |
Intracellular distribution of some enzymes of the glutamine utilisation pathway in rat lymphocytes.
Topics: Animals; Aspartate Aminotransferases; Cell Compartmentation; Cytosol; Glutamine; Lymphocytes; Malate Dehydrogenase; Malates; Mitochondria; NAD; Oxaloacetates; Phosphoenolpyruvate Carboxykinase (GTP); Pyruvate Carboxylase; Pyruvate Kinase; Pyruvates; Pyruvic Acid; Rats | 1986 |
The role of the hepatocellular redox state in the hepatic triglyceride accumulation following acute ethanol administration.
Topics: Acetaldehyde; Animals; Ethanol; Lactates; Lactic Acid; Lipid Metabolism; Liver; Male; NAD; Naloxone; Oxidation-Reduction; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains; Sorbitol; Triglycerides | 1986 |
Reduction-oxidation state and protein degradation in skeletal muscles of growing rats.
Topics: Animals; Body Weight; Lactates; Lactic Acid; Male; Muscle Development; Muscle Proteins; NAD; Oxidation-Reduction; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains | 1986 |
Pyruvate interference with continuous-flow (SMAC) methods for aspartate and alanine aminotransferases.
Topics: Alanine Transaminase; Aspartate Aminotransferases; Humans; L-Lactate Dehydrogenase; NAD; Pyruvates; Pyruvic Acid | 1987 |
Effect of redox potential on protein degradation in perfused rat heart.
Topics: Animals; Glucose; Heart; Insulin; Leucine; Malates; Male; Myocardium; NAD; Oxidation-Reduction; Perfusion; Phenylalanine; Proteins; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains | 1985 |
An enzymatic determination of D-glucaric acid by conversion to pyruvate.
Topics: Adult; Animals; Biological Assay; Escherichia coli; Female; Glucaric Acid; Glucuronidase; Humans; Hydro-Lyases; Male; NAD; Oxidation-Reduction; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains; Sugar Acids | 1985 |
Effect of glucose and insulin administration on hepatic adenylate energy charge and the cytosolic redox state in the neonates of normal and insulin-treated diabetic rats.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Animals; Animals, Newborn; Cytosol; Diabetes Mellitus, Experimental; Energy Metabolism; Female; Glucose; Insulin; Lactates; Lactic Acid; Liver; NAD; Oxidation-Reduction; Pregnancy; Pregnancy in Diabetics; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains | 1985 |
The effects of cyclopropane carboxylate on hepatic pyruvate metabolism.
Topics: Acyl Coenzyme A; Animals; Carbon Dioxide; Cyclopropanes; Gluconeogenesis; Ketone Bodies; Lactates; Lactic Acid; Liver; Male; NAD; Perfusion; Pyruvate Decarboxylase; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains | 1985 |
[Mitochondrial myopathies and encephalomyopathies. Neuromuscular and central nervous system diseases caused by defects in mitochondrial oxidative metabolism].
Topics: Brain; Brain Diseases, Metabolic; Carnitine O-Acetyltransferase; Child; Citric Acid Cycle; Cytochromes; Energy Metabolism; Enzymes; Humans; Lactates; Lactic Acid; Mitochondria, Muscle; Muscles; NAD; Neuromuscular Diseases; Pyruvate Dehydrogenase Complex Deficiency Disease; Pyruvates; Pyruvic Acid; Succinates; Succinic Acid | 1985 |
Functional studies on in situ-like mitochondria isolated in the presence of polyvinyl pyrrolidone.
Topics: Adenosine Diphosphate; Animals; Cell Fractionation; Coenzyme A; Cricetinae; Malates; Mesocricetus; Microscopy, Electron; Mitochondria, Heart; Mitochondrial Swelling; NAD; Oxygen Consumption; Povidone; Pyruvates; Pyruvic Acid | 1985 |
Oxidative metabolism of Polytron versus Nagarse mitochondria in hearts of genetically diabetic mice.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Acetyl-CoA C-Acyltransferase; Animals; Cell Fractionation; Diabetes Mellitus, Experimental; Malates; Mice; Mice, Inbred C57BL; Microscopy, Electron; Mitochondria, Heart; NAD; Oxidation-Reduction; Oxidative Phosphorylation; Palmitoylcarnitine; Pyruvates; Pyruvic Acid; Succinates; Succinic Acid | 1985 |
Pyruvate prevents the ATP depletion caused by formaldehyde or calcium-chelator esters in the human red cell.
Topics: Adenosine Triphosphate; Aminoquinolines; Erythrocytes; Formaldehyde; Glyceraldehyde-3-Phosphate Dehydrogenases; Humans; In Vitro Techniques; NAD; Pyruvates; Pyruvic Acid | 1985 |
The purification and steady-state kinetic behaviour of rabbit heart mitochondrial NAD(P)+ malic enzyme.
Topics: Animals; Chromatography, Affinity; Chromatography, DEAE-Cellulose; In Vitro Techniques; Kinetics; Malate Dehydrogenase; Mitochondria, Heart; Models, Biological; NAD; NADP; Pyruvates; Pyruvic Acid; Rabbits | 1985 |
The interaction and inhibition of muscle lactate dehydrogenase by the alkaloid caffeine.
Topics: Animals; Binding Sites; Binding, Competitive; Caffeine; Kinetics; L-Lactate Dehydrogenase; Muscles; NAD; Pyruvates; Pyruvic Acid; Rabbits | 1985 |
Red blood cell oxidative metabolism induced by hydroxypyruvaldehyde.
Topics: Adult; Blood Glucose; Erythrocytes; Free Radicals; Glutathione; Hemoglobins; Humans; In Vitro Techniques; Lactates; Lactic Acid; Malonates; Malondialdehyde; NAD; NADP; Oxidation-Reduction; Oxygen Consumption; Pentose Phosphate Pathway; Pyruvaldehyde; Pyruvates; Pyruvic Acid | 1985 |
The rates of defined changes in protein structure during the catalytic cycle of lactate dehydrogenase.
Topics: Animals; Chemical Phenomena; Chemistry; Isoenzymes; Kinetics; L-Lactate Dehydrogenase; Lactates; Lactic Acid; NAD; Oxidation-Reduction; Protein Conformation; Pyruvates; Pyruvic Acid; Swine | 1985 |
Bromopyruvate, a potential affinity label for octopine dehydrogenase.
Topics: Affinity Labels; Amino Acid Oxidoreductases; Kinetics; NAD; Oxidation-Reduction; Pyruvates; Pyruvic Acid | 1985 |
Redox status of cultured fibroblasts. Possible relations with specific catabolic rates of proteoglycans.
Topics: Aerobiosis; Anaerobiosis; Animals; Cells, Cultured; Fibroblasts; Glycolysis; Lactates; Lactic Acid; NAD; Oxidation-Reduction; Proteoglycans; Pyruvates; Pyruvic Acid; Rats | 1985 |
A comparison between effects of chronic ethanol consumption, ethanol withdrawal and fasting in ethanol-fed rats on the free cytosolic NADP+/NADPH ratio and NADPH-regenerating enzyme activities in the liver.
Topics: Alcoholism; Animals; Cytosol; Ethanol; Fasting; Fatty Acids; Glucose-6-Phosphate; Glucosephosphates; Isocitrate Dehydrogenase; Liver; Male; NAD; NADP; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome | 1985 |
The interaction between the cytosolic pyridine nucleotide redox potential and gluconeogenesis from lactate/pyruvate in isolated rat hepatocytes. Implications for investigations of hormone action.
Topics: Angiotensin II; Animals; Cytosol; Dexamethasone; Glucagon; Gluconeogenesis; Glyceraldehyde-3-Phosphate Dehydrogenases; Kinetics; Lactates; Lactic Acid; Liver; Malate Dehydrogenase; Male; NAD; Oxaloacetates; Oxidation-Reduction; Pyruvate Kinase; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains | 1985 |
Estimation of the relative contributions of enhanced production of oxalacetate and inhibition of pyruvate kinase to acute hormonal stimulation of gluconeogenesis in rat hepatocytes. An analysis of the effects of glucagon, angiotensin II, and dexamethasone
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Angiotensin II; Animals; Cytosol; Dexamethasone; Glucagon; Glucocorticoids; Gluconeogenesis; Glyceric Acids; Hormones; Kinetics; Lactates; Lactic Acid; Liver; Male; NAD; Oxaloacetates; Pyruvate Kinase; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains | 1985 |
Studies on the site of the block in gluconeogenesis causing severe hypoglycemia in intestinal ischemia shock in rats.
Topics: Adenosine Triphosphate; Alanine; Animals; Epinephrine; Female; Glucagon; Gluconeogenesis; Hypoglycemia; Intestines; Ischemia; NAD; Norepinephrine; Portal Vein; Pyruvates; Pyruvic Acid; Rats; Shock, Hemorrhagic | 1985 |
Carbohydrate metabolites in the blood and CSF of patients with neuromuscular disorders.
Topics: Blood Glucose; Brain Chemistry; Glucose; Humans; Lactates; NAD; Neuromuscular Diseases; Pyruvates; Pyruvic Acid | 1981 |
Regulation of the salvage pathway of purine nucleotide synthesis by the oxidation state of NAD+ in rat heart cells.
Topics: Animals; Carbon Dioxide; Carbon Radioisotopes; Cells, Cultured; Glycolysis; Hypoxanthine; Hypoxanthines; Lactates; Lactic Acid; Methylphenazonium Methosulfate; Myocardium; NAD; Phosphoribosyl Pyrophosphate; Purine Nucleotides; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains | 1984 |
[Peculiarities of carbohydrate metabolism in the rat liver due to the limited accessibility of thiamine].
Topics: Adenine Nucleotides; Animals; Carbohydrate Metabolism; Cyclic AMP; L-Lactate Dehydrogenase; Lactates; Lactic Acid; Liver; Male; NAD; Oxidation-Reduction; Pyruvates; Pyruvic Acid; Rats; Thiamine Deficiency | 1983 |
The stimulus-secretion coupling of amino acid-induced insulin release: metabolism of L-asparagine in pancreatic islets.
Topics: Acetyl Coenzyme A; Animals; Asparaginase; Asparagine; Aspartic Acid; Cytosol; Fatty Acids; Islets of Langerhans; Kinetics; Mitochondria; NAD; NADP; Oxaloacetates; Oxidation-Reduction; Pyruvates; Pyruvic Acid; Rats | 1984 |
In situ behaviour of D(-)-lactate dehydrogenase from Escherichia coli.
Topics: Escherichia coli; Hydrogen-Ion Concentration; Kinetics; L-Lactate Dehydrogenase; NAD; Pyruvates; Pyruvic Acid | 1984 |
The structure of the abortive nicotinamide adenine dinucleotide-pyruvate-lactate dehydrogenase complex as determined by circular dichroism.
Topics: Animals; Butyrates; Chromatography, Thin Layer; Circular Dichroism; L-Lactate Dehydrogenase; Multienzyme Complexes; NAD; Pyruvates; Pyruvic Acid; Swine | 1983 |
Analysis of the circadian rhythm in energy metabolism of rat liver.
Topics: Adenine Nucleotides; Animals; Circadian Rhythm; Energy Metabolism; Glucose; Glycolysis; Kinetics; Liver; Male; NAD; NADP; Oxaloacetates; Oxidation-Reduction; Phosphoenolpyruvate; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains | 1984 |
The effect of ketone bodies and fatty acid on intestinal glucose metabolism during development.
Topics: 3-Hydroxybutyric Acid; Animal Population Groups; Animals; Animals, Suckling; Fatty Acids; Female; Glucose; Hydroxybutyrates; Intestinal Mucosa; Ketone Bodies; Lactates; Lactic Acid; Male; NAD; Oxidation-Reduction; Palmitic Acid; Palmitic Acids; Pyruvate Dehydrogenase Complex; Pyruvates; Pyruvic Acid; Rats | 1984 |
The use of auramine O to study ligand binding and subunit cooperativity of lactate dehydrogenase.
Topics: Adenosine Diphosphate; Aniline Compounds; Animals; Benzophenoneidum; Fluorometry; L-Lactate Dehydrogenase; Macromolecular Substances; Mathematics; Muscles; NAD; Pyruvates; Pyruvic Acid; Swine | 1984 |
Intramolecular hydride transfer of a combined coenzyme-substrate analog by D- and L-lactate dehydrogenases.
Topics: Animals; Chemical Phenomena; Chemistry; Chromatography, Thin Layer; Coenzymes; Cyanides; Horseshoe Crabs; Kinetics; L-Lactate Dehydrogenase; Lactobacillus; Muscles; NAD; Oxidation-Reduction; Pyruvates; Pyruvic Acid; Stereoisomerism; Swine | 1984 |
Stimulation of glycogenolysis and platelet-activating factor production by heat-aggregated immunoglobulin G in the perfused rat liver.
Topics: Animals; Hot Temperature; Immunoglobulin G; Lactates; Lactic Acid; Liver; Liver Glycogen; Male; NAD; Oxygen Consumption; Perfusion; Platelet Activating Factor; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains | 1984 |
Kinetic mechanism in the direction of oxidative decarboxylation for NAD-malic enzyme from Ascaris suum.
Topics: Animals; Ascaris; Binding, Competitive; Kinetics; Magnesium; Malate Dehydrogenase; Malates; NAD; Pyruvates; Pyruvic Acid; Tartronates | 1984 |
Effect of lactate and pyruvate on cerebrocortical microcirculation and NAD/NADH redox state.
Topics: Animals; Cats; Cerebral Cortex; Cerebrovascular Circulation; Lactates; Lactic Acid; Microcirculation; NAD; Oxidation-Reduction; Pyruvates; Pyruvic Acid | 1984 |
L-amino acids from a racemic mixture of alpha-hydroxy acids.
Topics: Alanine; Alanine Dehydrogenase; Amino Acid Oxidoreductases; Kinetics; L-Lactate Dehydrogenase; Lactates; Lactic Acid; NAD; Pyruvates; Pyruvic Acid; Stereoisomerism | 1984 |
Evidence for the role of malic enzyme in the rapid oxidation of malate by cod heart mitochondria.
Topics: Animals; Fishes; Malate Dehydrogenase; Malates; Mitochondria, Heart; NAD; NADP; Oxidation-Reduction; Pyruvates; Pyruvic Acid; Rabbits; Rats; Species Specificity | 1984 |
The kinetic mechanism of pyruvate reduction by lactate dehydrogenase from Phycomyces blakesleeanus.
Topics: Fungi; Hydrogen-Ion Concentration; Kinetics; L-Lactate Dehydrogenase; Lactates; Lactic Acid; NAD; Oxidation-Reduction; Phycomyces; Pyruvates; Pyruvic Acid | 1984 |
High-pressure enzyme kinetics. Lactate dehydrogenase in an optical cell that allows a reaction to be started under high pressure.
Topics: Animals; Hydrostatic Pressure; Kinetics; L-Lactate Dehydrogenase; Macromolecular Substances; Muscles; NAD; Pressure; Pyruvates; Pyruvic Acid; Rabbits; Spectrophotometry, Ultraviolet | 1984 |
Octopine dehydrogenase from Pecten maximus: steady-state mechanism.
Topics: Amino Acid Oxidoreductases; Arginine; NAD; Plants; Pyruvates; Pyruvic Acid | 1984 |
The effect of glyceraldehyde on red cells. Haemoglobin status, oxidative metabolism and glycolysis.
Topics: Blood Glucose; Erythrocytes; Glutathione; Glyceraldehyde; Glycolysis; Hemoglobins; Hexosephosphates; Humans; Lactates; Lactic Acid; Lactoylglutathione Lyase; NAD; NADP; Oxidation-Reduction; Oxygen Consumption; Pyruvates; Pyruvic Acid; Thiolester Hydrolases | 1984 |
Acute effect of ethanol on metabolite concentrations of dog pancreas in vivo.
Topics: Amino Acids; Animals; Dogs; Ethanol; Female; Lactates; Lactic Acid; Male; NAD; Pancreas; Pyruvates; Pyruvic Acid | 1982 |
the involvement of Nitric Oxide in the inhibition of the phosphoroclastic system in Clostridium sporogenes by sodium nitrite.
Topics: Acetates; Adenosine Triphosphate; Carbon Dioxide; Clostridium; Hydrogen; Kinetics; NAD; Nitrates; Nitric Oxide; Organophosphates; Oxidation-Reduction; Pyruvates; Pyruvic Acid | 1981 |
The regulation of the pyruvate dehydrogenase complex in the perfused rat liver: a role for the mitochondrial monocarboxylate translocator.
Topics: 3-Hydroxybutyric Acid; Acetyl Coenzyme A; Animals; Carbon Dioxide; Carrier Proteins; Hydroxybutyrates; Liver; Male; Monocarboxylic Acid Transporters; NAD; Perfusion; Pyruvate Dehydrogenase Complex; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains | 1982 |
The role of lipoic acid residues in the pyruvate dehydrogenase multienzyme complex of Escherichia coli.
Topics: Acetyl Coenzyme A; Acetylation; Escherichia coli; Ethylmaleimide; NAD; Pyruvate Dehydrogenase Complex; Pyruvates; Pyruvic Acid; Thioctic Acid | 1981 |
The reactions of pyridoxal 5'-phosphate with the M4 and H4 isoenzymes of pig lactate dehydrogenase.
Topics: Animals; Dose-Response Relationship, Drug; Isoenzymes; L-Lactate Dehydrogenase; Lysine; Myocardium; NAD; Pyridoxal Phosphate; Pyruvates; Pyruvic Acid; Spectrophotometry; Sulfhydryl Compounds; Swine | 1982 |
H4-isozyme of lactate dehydrogenase in the solution of sodium chloride--3. The enzymatic activity and the pyruvate inhibition.
Topics: Isoenzymes; Kinetics; L-Lactate Dehydrogenase; Molecular Weight; NAD; Pyruvates; Pyruvic Acid; Sodium Chloride; Solutions | 1983 |
Age-related changes in rat adipose tissue in response to fasting: protein, lactate and pyruvate levels.
Topics: Adipose Tissue; Aging; Animals; Fasting; Lactates; Lactic Acid; Male; NAD; Proteins; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains | 1983 |
Effect of ischemia on fatty acid metabolism in fetal lung.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Fatty Acids; Female; Fetus; Ischemia; Kinetics; Lactates; Lactic Acid; Lung; NAD; Oxidation-Reduction; Pregnancy; Pulmonary Circulation; Pyruvates; Pyruvic Acid; Rabbits | 1983 |
The stimulus-secretion coupling of amino acid-induced insulin release. Metabolic interaction of L-glutamine and 2-ketoisocaproate in pancreatic islets.
Topics: Animals; Drug Synergism; Glutamine; Insulin; Insulin Secretion; Islets of Langerhans; Keto Acids; NAD; NADP; Oxidation-Reduction; Pyruvates; Pyruvic Acid; Rats; Transaminases | 1981 |
Partial purification and characterization of lactate dehydrogenase from Plasmodium falciparum.
Topics: Animals; Centrifugation; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Deoxycholic Acid; Erythrocytes; Kinetics; L-Lactate Dehydrogenase; NAD; Plasmodium falciparum; Pyruvates; Pyruvic Acid | 1981 |
Changes in NAD(P)+-dependent malic enzyme and malate dehydrogenase activities during fibroblast proliferation.
Topics: Cell Division; Cell Fractionation; Cells, Cultured; Fibroblasts; Humans; Lactates; Lactic Acid; Malate Dehydrogenase; Malates; Manganese; Mitochondria; NAD; NADP; Oxaloacetates; Pyruvates; Pyruvic Acid | 1982 |
Studies of lactate dehydrogenase in the purified state and in intact erythrocytes.
Topics: Erythrocytes; Humans; In Vitro Techniques; Kinetics; L-Lactate Dehydrogenase; Lactates; Lactic Acid; Magnetic Resonance Spectroscopy; Models, Biological; NAD; Oxalates; Oxalic Acid; Pyruvates; Pyruvic Acid | 1982 |
Changes in some metabolites contents of the carbohydrate metabolism in mouse submandibular salivary gland after stimulation by isoproterenol.
Topics: Animals; Carbohydrate Metabolism; Citrates; Citric Acid; Isoproterenol; Lactates; Lactic Acid; Male; Mice; NAD; Pyruvates; Pyruvic Acid; Submandibular Gland | 1982 |
A simple, rapid method for the determination of glucose, lactate, pyruvate, alanine, 3-hydroxybutyrate and acetoacetate on a single 20-mul blood sample.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Alanine; Blood Glucose; Fluorometry; Humans; Hydroxybutyrates; Keto Acids; Lactates; Lactic Acid; Methods; Microchemistry; NAD; Physical Exertion; Pyruvates; Pyruvic Acid; Spectrophotometry; Starvation | 1982 |
Lactate dehydrogenase in Phycomyces blakesleeanus.
Topics: Adenosine Triphosphate; Carboxylic Acids; Coenzymes; Fungi; Guanosine Triphosphate; Kinetics; L-Lactate Dehydrogenase; NAD; Phycomyces; Pyruvates; Pyruvic Acid; Substrate Specificity | 1982 |
Influence of pH on the allosteric properties of lactate dehydrogenase activity of Phycomyces blakesleeanus.
Topics: Allosteric Site; Enzyme Activation; Fructosediphosphates; Fungi; Hydrogen-Ion Concentration; Kinetics; L-Lactate Dehydrogenase; NAD; Phycomyces; Pyruvates; Pyruvic Acid | 1982 |
NAD(P) adducts as protective agents against glutamate dehydrogenase inactivation by pyridoxal 5'-phosphate: a tool for the study of oxidized coenzyme activated state in enzymatic evolutive and abortive complexes.
Topics: Animals; Cattle; Chemical Phenomena; Chemistry; Glutamate Dehydrogenase; Ketoglutaric Acids; Male; NAD; NADP; Nicotinamide Mononucleotide; Oxaloacetates; Pyridoxal Phosphate; Pyruvates; Pyruvic Acid; Structure-Activity Relationship; Time Factors | 1982 |
Relationship of the reduction-oxidation state to protein degradation in skeletal and atrial muscle.
Topics: Animals; Diaphragm; Heart Atria; Lactates; Lactic Acid; Leucine; Malates; Male; Muscle Proteins; Muscles; NAD; Oxidation-Reduction; Protease Inhibitors; Pyruvates; Pyruvic Acid; Rats | 1982 |
Intracellular oxygen supply during hypoxia.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Anaerobiosis; Animals; Cytochromes; Glutathione; Hypoxia; In Vitro Techniques; Kinetics; Lactates; Lactic Acid; Liver; Male; Mitochondria, Liver; NAD; Oxidation-Reduction; Oxygen Consumption; Pyruvates; Pyruvic Acid; Rats | 1982 |
Fumarate reduction and product formation by the Reiter strain of Treponema phagedenis.
Topics: Acetates; Acetyl Coenzyme A; Butyrates; Culture Media; Electron Transport; Ethanol; Ferredoxins; Flavin-Adenine Dinucleotide; Fumarates; Glucose; NAD; NADP; Oxidation-Reduction; Pyruvates; Pyruvic Acid; Succinates; Treponema | 1982 |
Determination of D-lactate in plasma.
Topics: Catalysis; Humans; Hydrogen-Ion Concentration; L-Lactate Dehydrogenase; Lactates; Lactic Acid; NAD; Oxidation-Reduction; Pyruvates; Pyruvic Acid; Spectrophotometry | 1982 |
Lactate dehydrogenase isozymes from mouse.
Topics: Animals; Chromatography, Affinity; Isoenzymes; L-Lactate Dehydrogenase; Male; Mice; Mice, Inbred C57BL; NAD; Pyruvates; Pyruvic Acid; Testis | 1982 |
A 1H n.m.r. study of the kinetic properties expressed by glyceraldehyde phosphate dehydrogenase in the intact human erythrocyte.
Topics: Erythrocyte Membrane; Erythrocytes; Glyceraldehyde-3-Phosphate Dehydrogenases; Humans; In Vitro Techniques; Iodoacetates; Iodoacetic Acid; Kinetics; Lactates; Lactic Acid; Magnetic Resonance Spectroscopy; Models, Biological; NAD; Pyruvates; Pyruvic Acid | 1982 |
NAD(P)-dependent malic enzyme activity in human term placental mitochondria.
Topics: Cations; Female; Humans; In Vitro Techniques; Malate Dehydrogenase; Manganese; Mitochondria; NAD; NADP; Oxaloacetates; Placenta; Pregnancy; Pregnancy Trimester, Third; Pyruvates; Pyruvic Acid | 1982 |
[Changes in the oxidative metabolism of the brain in the elderly].
Topics: Adult; Aged; Brain; Glucose; Humans; Lactates; Lactic Acid; Middle Aged; NAD; Oxidation-Reduction; Pyruvates; Pyruvic Acid | 1981 |
Effect of increasing the intracellular ratio of NADH to NAD+ on human erythrocyte metabolism: new estimation of the turnover through the phosphoglycerate shunt.
Topics: 2,3-Diphosphoglycerate; Adenine Nucleotides; Diphosphoglyceric Acids; Erythrocytes; Glyceric Acids; Humans; In Vitro Techniques; Lactates; Lactic Acid; NAD; Organophosphorus Compounds; Oxidation-Reduction; Phosphates; Pyruvates; Pyruvic Acid | 1981 |
The specific inhibition of the pyruvate dehydrogenase complex from pig kidney by propionyl-CoA and isovaleryl-Co-A.
Topics: Acyl Coenzyme A; Animals; Coenzyme A; Kidney; NAD; Propionates; Pyruvate Dehydrogenase Complex; Pyruvates; Pyruvic Acid; Swine; Valerates | 1981 |
Calcutta-1 LDH: kinetic and thermodynamic properties of an electrophoretic variant of human LDH.
Topics: Drug Stability; Genetic Variation; Heterozygote; Hot Temperature; Humans; Hydrogen-Ion Concentration; Isoenzymes; Kinetics; L-Lactate Dehydrogenase; NAD; Pyruvates; Pyruvic Acid; Thermodynamics | 1981 |
Theoretical study on preference of metabolic fuels in heart muscle cells.
Topics: Acetates; Acetyl Coenzyme A; Adenosine Triphosphate; Energy Metabolism; Kinetics; Models, Biological; Myocardium; NAD; Pyruvate Dehydrogenase Complex; Pyruvates; Pyruvic Acid | 1981 |
Biochemical mechanism of infarct size reduction by pyruvate.
Topics: Adenosine Triphosphate; Animals; Dogs; Heart; Myocardial Infarction; Myocardium; NAD; Pyruvates; Pyruvic Acid | 1981 |
Separation of rat lactate dehydrogenase isoenzyme C4 from other isoenzymes by affinity and ion-exchange chromatography.
Topics: Animals; Chromatography, Affinity; Chromatography, DEAE-Cellulose; Chromatography, Liquid; Isoenzymes; L-Lactate Dehydrogenase; Male; NAD; Pyruvates; Pyruvic Acid; Rats; Testis | 1981 |
Effect of cyanamide on the metabolism of ethanol and acetaldehyde and on gluconeogenesis by isolated rat hepatocytes.
Topics: Acetaldehyde; Animals; Cyanamide; Cyanides; Ethanol; Gluconeogenesis; In Vitro Techniques; Liver; Male; NAD; Oxidation-Reduction; Pyrazoles; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains; Sorbitol; Xylitol | 1981 |
Knowledge-based modeling of the D-lactate dehydrogenase three-dimensional structure.
Topics: Amino Acid Sequence; Animals; Binding Sites; Dogfish; L-Lactate Dehydrogenase; Lactobacillus; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; NAD; Protein Conformation; Pyruvates; Pyruvic Acid | 1995 |
Increase of cardiac work is associated with decrease of mitochondrial NADH.
Topics: Animals; Cardiac Pacing, Artificial; Fluorescence; Heart; Heart Rate; Hemodynamics; Male; Mitochondria; NAD; Oxidation-Reduction; Oxygen Consumption; Pyruvates; Pyruvic Acid; Rats; Rats, Wistar; Ultraviolet Rays | 1995 |
Hepatocyte injury resulting from the inhibition of mitochondrial respiration at low oxygen concentrations involves reductive stress and oxygen activation.
Topics: Adenosine Triphosphate; Animals; Antimycin A; Antioxidants; Cell Death; Cell Hypoxia; Cyanides; Ethanol; Hydrogen Peroxide; Iron; Lactates; Lactic Acid; Liver; Male; Mitochondria, Liver; NAD; Oxidation-Reduction; Oxygen Consumption; Pyruvates; Pyruvic Acid; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species | 1995 |
Lactate dehydrogenase M-subunit deficiencies: clinical features, metabolic background, and genetic heterogeneities.
Topics: Adolescent; Adult; Base Sequence; DNA; Exercise; Female; Glyceraldehyde-3-Phosphate Dehydrogenases; Glycolysis; Humans; L-Lactate Dehydrogenase; Lactates; Lactic Acid; Male; Molecular Sequence Data; Mutation; Myoglobinuria; NAD; Oxidation-Reduction; Pyruvates; Pyruvic Acid; Skin Diseases | 1995 |
The cumulative nature of pyruvate's dual mechanism for myocardial protection.
Topics: Adenosine Triphosphate; Animals; Creatine Kinase; Magnetic Resonance Spectroscopy; Male; Myocardial Reperfusion Injury; Myocardium; NAD; Pyruvates; Pyruvic Acid; Rats; Rats, Sprague-Dawley | 1995 |
Octanoate affects 2,4-dinitrophenol uncoupling in intact isolated rat hepatocytes.
Topics: 2,4-Dinitrophenol; Adenine Nucleotides; Animals; Aspartic Acid; Caprylates; Cell Separation; Dihydroxyacetone; Dinitrophenols; Electron Transport; Fatty Acids; Glucose; Lactates; Lactic Acid; Liver; Malates; Male; NAD; Oxidation-Reduction; Oxygen Consumption; Pyruvates; Pyruvic Acid; Rats; Rats, Wistar | 1995 |
The effect of temperature on enzymes used in diagnostics.
Topics: Alcohol Dehydrogenase; Animals; Glucokinase; Glucosephosphate Dehydrogenase; Indicators and Reagents; Kinetics; L-Lactate Dehydrogenase; Muscles; NAD; Pharmaceutical Preparations; Protein Denaturation; Pyruvates; Pyruvic Acid; Rabbits; Temperature; Thermodynamics; Zymomonas | 1995 |
In vivo effects of lipopolysaccharide on hepatic free-NAD(P)(+)-linked redox states and cytosolic phosphorylation potential in 48-hour-fasted rats.
Topics: 3-Hydroxybutyric Acid; Animals; Cytosol; Fasting; Hydroxybutyrates; Injections, Intraperitoneal; Ketone Bodies; Kinetics; Lipopolysaccharides; Liver; Male; NAD; NADP; Oxidation-Reduction; Phosphorylation; Pyruvates; Pyruvic Acid; Rats; Rats, Sprague-Dawley; Urea | 1995 |
The isoenzyme forms of lactate dehydrogenase from the testes of Uromastix hardwickii.
Topics: Animals; Chromatography, Agarose; Colchicine; Electrophoresis, Polyacrylamide Gel; Ethanolamines; Hydrogen-Ion Concentration; Isoenzymes; Kinetics; L-Lactate Dehydrogenase; Lactates; Lactic Acid; Lizards; Male; NAD; Pyruvates; Pyruvic Acid; Testis | 1994 |
Purification and properties of lactate dehydrogenase from liver of Uromastix hardwickii.
Topics: Animals; Cations, Divalent; Electrophoresis, Agar Gel; Electrophoresis, Polyacrylamide Gel; Enzyme Stability; Glutamic Acid; Hot Temperature; Hydrogen-Ion Concentration; Isoenzymes; Kinetics; L-Lactate Dehydrogenase; Lactates; Lactic Acid; Liver; Lizards; Molecular Weight; NAD; Oxalates; Oxalic Acid; Pyruvates; Pyruvic Acid | 1995 |
Assay of dehydrogenases with an O2-consuming biosensor.
Topics: Animals; Bacterial Proteins; Biosensing Techniques; Cell Survival; Chloromercuribenzoates; Electrodes; Electron Transport; Enzymes, Immobilized; Equipment Design; Escherichia coli; L-Lactate Dehydrogenase; Lactates; Lactic Acid; Mixed Function Oxygenases; NAD; Oxidation-Reduction; Oxidoreductases; Oxygen; p-Chloromercuribenzoic Acid; Pyruvates; Pyruvic Acid; Sensitivity and Specificity | 1994 |
Calcium and 2-oxoglutarate-mediated control of aspartate formation by rat heart mitochondria.
Topics: Animals; Aspartic Acid; Calcium; Dinitrophenols; Enzyme Activation; Glutamates; Glutamic Acid; Ketoglutarate Dehydrogenase Complex; Ketoglutaric Acids; Malates; Membrane Potentials; Mitochondria, Heart; Models, Biological; NAD; Pyruvates; Pyruvic Acid; Rats | 1994 |
Possible role of cell redox state on collagen metabolism in carbon tetrachloride-induced cirrhosis as evidenced by adenosine administration to rats.
Topics: 3-Hydroxybutyric Acid; Adenosine; Animals; Carbon Tetrachloride; Collagen; Hydroxybutyrates; Lactates; Lactic Acid; Liver Cirrhosis, Experimental; Male; Mitochondria, Liver; NAD; Oxidation-Reduction; Pyruvates; Pyruvic Acid; Rats; Rats, Wistar | 1994 |
Changes in mitochondrial function induced in isolated guinea-pig ventricular myocytes by calcium overload.
Topics: Animals; Calcium; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cyanides; Fluorescent Dyes; Fura-2; Glucose; Guinea Pigs; Heart Ventricles; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Membrane Potentials; Mitochondria, Heart; Myocardium; NAD; Oxygen Consumption; Pyruvates; Pyruvic Acid | 1994 |
Type-2 astrocytes have much greater susceptibility to heat stress than type-1 astrocytes.
Topics: Animals; Animals, Newborn; Astrocytes; Cells, Cultured; Cytosol; Heat-Shock Proteins; Hot Temperature; Lactates; Lactic Acid; NAD; Oxidation-Reduction; Pyruvates; Pyruvic Acid; Rats; Stress, Physiological | 1994 |
Source of catalysis in the lactate dehydrogenase system. Ground-state interactions in the enzyme-substrate complex.
Topics: Animals; Catalysis; Geobacillus stearothermophilus; L-Lactate Dehydrogenase; NAD; Pyruvates; Pyruvic Acid; Spectrum Analysis, Raman; Substrate Specificity; Swine; Thermodynamics | 1994 |
Alternatives to arginine as energy sources for the non-fermentative Mycoplasma gallinarum.
Topics: Acetoacetates; Arginine; Carboxylic Acids; Ethanol; Lactates; Lactic Acid; Mycoplasma; NAD; Oxidation-Reduction; Pyruvates; Pyruvic Acid | 1994 |
Metabolic protection of post-ischemic phosphorylation potential and ventricular performance.
Topics: Adenosine Triphosphate; Animals; Cardiotonic Agents; Coronary Circulation; Guinea Pigs; In Vitro Techniques; Myocardial Reperfusion Injury; NAD; Phosphorylation; Pyruvates; Pyruvic Acid; Ventricular Function, Left | 1993 |
Kinetic analysis of lactate dehydrogenase using integrated rate equations.
Topics: Animals; Binding, Competitive; Isoenzymes; Kinetics; L-Lactate Dehydrogenase; Mathematics; NAD; Pyruvates; Pyruvic Acid; Rabbits; Regression Analysis; Serum Albumin, Bovine | 1993 |
The role of reduced nicotinamide adenine dinucleotide phosphate in glucose- and temperature-dependent doxorubicin cytotoxicity.
Topics: Animals; Cell Survival; Culture Media; DNA Damage; Doxorubicin; Drug Resistance; Glucose; Glutamine; L Cells; Methylene Blue; Mice; NAD; NADP; Oxidation-Reduction; Pyruvates; Pyruvic Acid; Temperature; Uridine | 1993 |
Oxidation of pyruvate, malate, citrate, and cytosolic reducing equivalents by AS-30D hepatoma mitochondria.
Topics: Aconitate Hydratase; Animals; Citrates; Citric Acid; Citric Acid Cycle; Cytosol; Electrochemistry; Fatty Acids; Female; Isocitrate Dehydrogenase; Kinetics; Liver Neoplasms, Experimental; Malate Dehydrogenase; Malates; Mitochondria, Liver; NAD; Oxidation-Reduction; Pyruvate Dehydrogenase Complex; Pyruvates; Pyruvic Acid; Rats; Rats, Sprague-Dawley | 1993 |
Inhibition of glutamate dehydrogenase by covalent coenzyme-substrate adducts: a re-examination.
Topics: Animals; Cattle; Glutamate Dehydrogenase; Hydrogen-Ion Concentration; Ketoglutaric Acids; Kinetics; NAD; Oxidation-Reduction; Pyruvates; Pyruvic Acid | 1993 |
Organic acid activation of the alternative oxidase of plant mitochondria.
Topics: Enzyme Activation; Glycine max; Malates; Mitochondria; NAD; Oxidation-Reduction; Oxidoreductases; Oxygen; Pyruvates; Pyruvic Acid; Substrate Specificity; Succinates; Succinic Acid | 1993 |
Stoichiometry, organisation and catalytic function of protein X of the pyruvate dehydrogenase complex from bovine heart.
Topics: Acetyl Coenzyme A; Acetylation; Animals; Cattle; Collagenases; Cross-Linking Reagents; Myocardium; NAD; Peptides; Protein Conformation; Pyruvate Dehydrogenase Complex; Pyruvates; Pyruvic Acid; Thioctic Acid | 1996 |
Effects of the nonsteroidal anti-inflammatory drug piroxicam on energy metabolism in the perfused rat liver.
Topics: Adenosine Triphosphate; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Antimycin A; Atractyloside; Drug Interactions; Energy Metabolism; Fasting; Gluconeogenesis; Glucose; Glycogen; Lactates; Lactic Acid; Liver; Male; Mitochondria, Liver; NAD; NADP; Oxygen Consumption; Perfusion; Piroxicam; Pyruvates; Pyruvic Acid; Rats; Rats, Wistar | 1996 |
Inhibition studies on LDH isoenzyme purified from Uromastix testes.
Topics: Animals; Antineoplastic Agents; Caproates; Cisplatin; Enzyme Inhibitors; Gossypol; Isoenzymes; L-Lactate Dehydrogenase; Lizards; Male; NAD; Oxalates; Oxalic Acid; Pyruvic Acid; Testis | 1996 |
Oscillations in oxygen consumption by permeabilized clonal pancreatic beta-cells (HIT) incubated in an oscillatory glycolyzing muscle extract: roles of free Ca2+, substrates, and the ATP/ADP ratio.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Calcium; Cell Membrane Permeability; Clone Cells; Egtazic Acid; Fructosediphosphates; Glycerophosphates; Glycolysis; Islets of Langerhans; Kinetics; Muscle, Skeletal; NAD; Oscillometry; Oxygen Consumption; Pyruvic Acid; Rats; Spectrometry, Fluorescence; Thapsigargin | 1997 |
Identification of lysine 74 in the pyruvate binding site of alanine dehydrogenase from Bacillus subtilis. Chemical modification with 2,4,6-trinitrobenzenesulfonic acid, n-succinimidyl 3-(2-pyridyldithio)propionate, and 5'-(p-(fluorosulfonyl)benzoyl)adenos
Topics: Adenosine; Affinity Labels; Alanine Dehydrogenase; Amino Acid Oxidoreductases; Amino Acid Sequence; Bacillus subtilis; Binding Sites; Chromatography, High Pressure Liquid; Cross-Linking Reagents; Molecular Sequence Data; NAD; Pyruvic Acid; Sequence Alignment; Spectrophotometry, Atomic; Succinimides; Trinitrobenzenesulfonic Acid | 1997 |
The acetate kinase of Clostridum acetobutylicum strain P262.
Topics: Acetate Kinase; Acetates; Chromatography, Agarose; Chromatography, DEAE-Cellulose; Chromatography, Ion Exchange; Clostridium; Electrophoresis, Polyacrylamide Gel; Fermentation; Glucose; Hydrogen-Ion Concentration; Lactic Acid; NAD; Phosphate Acetyltransferase; Phosphotransferases (Carboxyl Group Acceptor); Pyruvic Acid | 1996 |
Hepatic glucose production from L-alanine is absent in perfused liver of diabetic rats.
Topics: Alanine; Alloxan; Animals; Anti-Bacterial Agents; Diabetes Mellitus, Experimental; Gluconeogenesis; Glucose; Glycerol; Infusions, Intravenous; Lactic Acid; Liver; Male; NAD; Perfusion; Pyruvic Acid; Rats; Rats, Wistar; Software; Sorbitol; Streptozocin | 1997 |
Cytoplasmic redox potential affects energetics and contractile reactivity of vascular smooth muscle.
Topics: Aerobiosis; Animals; Calcium; Caprylates; Carotid Arteries; Citric Acid Cycle; Cytoplasm; Energy Metabolism; Glucose; Glucosephosphate Dehydrogenase; Ion Transport; L-Lactate Dehydrogenase; Lactates; Mitochondria, Muscle; Muscle Contraction; Muscle, Smooth, Vascular; NAD; Oxidation-Reduction; Oxygen Consumption; Potassium Chloride; Pyruvic Acid; Sarcolemma; Swine; Vasoconstriction | 1997 |
Control of the shift from homolactic acid to mixed-acid fermentation in Lactococcus lactis: predominant role of the NADH/NAD+ ratio.
Topics: Acetyltransferases; Fermentation; Galactose; Glucose; Glyceraldehyde-3-Phosphate Dehydrogenases; Kinetics; L-Lactate Dehydrogenase; Lactic Acid; Lactococcus lactis; Lactose; NAD; Pyruvic Acid | 1997 |
Metabolic responses of pyruvate decarboxylase-negative Saccharomyces cerevisiae to glucose excess.
Topics: Acetyl Coenzyme A; Citric Acid Cycle; Glucose; Glycolysis; Kinetics; NAD; Oxygen Consumption; Phosphorylation; Pyruvate Decarboxylase; Pyruvic Acid; Saccharomyces cerevisiae | 1997 |
Action of polyamine aminotransferase on norspermidine.
Topics: Acrolein; Alanine; Allylamine; Arthrobacter; Biogenic Polyamines; Diamines; Kinetics; NAD; Pyruvic Acid; Spermidine; Transaminases | 1997 |
Pyruvate improves deleterious effects of high glucose on activation of pentose phosphate pathway and glutathione redox cycle in endothelial cells.
Topics: Adenosine Triphosphate; Cells, Cultured; Endothelium, Vascular; Fructosediphosphates; Glucose; Glutathione; Humans; Hydrogen Peroxide; Lactic Acid; NAD; NADP; Oxidation-Reduction; Pentose Phosphate Pathway; Pyruvic Acid; Umbilical Veins | 1997 |
Molecular mechanism of regulation of the pyruvate dehydrogenase complex from E. coli.
Topics: Coenzymes; Diethyl Pyrocarbonate; Enzyme Activation; Escherichia coli; Kinetics; NAD; Protein Binding; Pyruvate Dehydrogenase Complex; Pyruvic Acid; Spectrometry, Fluorescence; Thiamine Pyrophosphate; Tryptophan | 1997 |
Pyruvate augments calcium transients and cell shortening in rat ventricular myocytes.
Topics: Animals; Calcium; Cells, Cultured; Cytosol; Glucose; Heart; Heart Ventricles; Lactic Acid; Male; Mitochondria, Heart; Models, Cardiovascular; Myocardial Contraction; Myocardium; NAD; NADP; Phosphorylation; Pyruvic Acid; Rats; Rats, Wistar | 1998 |
Studies of the catabolic pathway of degradation of nitrobenzene by Pseudomonas pseudoalcaligenes JS45: removal of the amino group from 2-aminomuconic semialdehyde.
Topics: Acetaldehyde; Aldehyde Oxidoreductases; Aminohydrolases; Aminomuconate-Semialdehyde Dehydrogenase; Ammonia; Biodegradation, Environmental; Crotonates; Environmental Pollutants; Models, Chemical; NAD; Nitrobenzenes; Pseudomonas; Pyruvic Acid; Sorbic Acid; Spectrophotometry | 1997 |
Effect of chronic ethanol consumption on respiratory and glycolytic activities of rat periportal and perivenous hepatocytes.
Topics: Adenosine Triphosphate; Alcohol Drinking; Anaerobiosis; Animals; Ascorbic Acid; Cell Respiration; Cells, Cultured; Ethanol; Glucosyltransferases; Glycogen; Glycolysis; Glycoproteins; Lactic Acid; Liver; Male; Mice; NAD; Oxygen Consumption; Pyruvic Acid; Rats; Rats, Sprague-Dawley | 1998 |
Substrate inhibition of D-amino acid transaminase and protection by salts and by reduced nicotinamide adenine dinucleotide: isolation and initial characterization of a pyridoxo intermediate related to inactivation.
Topics: Alanine; Catalysis; Chromatography, High Pressure Liquid; D-Alanine Transaminase; Enzyme Inhibitors; NAD; Pyridoxal Phosphate; Pyridoxamine; Pyruvic Acid; Salts; Serine; Transaminases | 1998 |
Electron transport-mediated wasteful consumption of NADH promotes the lethal response of U937 cells to tert-butylhydroperoxide.
Topics: Adenosine Triphosphate; Cell Death; Electron Transport; Humans; Membrane Potentials; Mitochondria; NAD; Oxygen Consumption; Peroxides; Pyruvic Acid; Rotenone; Sulfhydryl Compounds; tert-Butylhydroperoxide; Tumor Cells, Cultured | 1998 |
Substrate and cofactor specificity and selective inhibition of lactate dehydrogenase from the malarial parasite P. falciparum.
Topics: Allosteric Regulation; Amino Acid Sequence; Animals; Binding Sites; Binding, Competitive; Enzyme Inhibitors; Gossypol; Humans; Isoelectric Point; Kinetics; L-Lactate Dehydrogenase; Lactic Acid; Molecular Sequence Data; NAD; Plasmodium falciparum; Pyruvic Acid; Recombinant Proteins; Substrate Specificity | 1997 |
Influence of polyethylene glycol on lactate dehydrogenase.
Topics: Animals; Enzyme Inhibitors; Enzyme Stability; Hot Temperature; Kinetics; L-Lactate Dehydrogenase; Muscle, Skeletal; NAD; Polyethylene Glycols; Protein Conformation; Pyruvic Acid; Swine | 1998 |
Some kinetic properties of lactate dehydrogenase activity in cell extracts from a mammalian (ovine) corneal epithelium.
Topics: Animals; Cell Extracts; Enzyme Stability; Epithelium, Corneal; Female; Hydrogen-Ion Concentration; Kinetics; L-Lactate Dehydrogenase; NAD; Oxidation-Reduction; Pyruvic Acid; Sheep | 1998 |
The importance of the glycerol 3-phosphate shuttle during aerobic growth of Saccharomyces cerevisiae.
Topics: Aerobiosis; Ethanol; Glycerol; Glycerol-3-Phosphate Dehydrogenase (NAD+); Glycerolphosphate Dehydrogenase; Glycerophosphates; Hydrogen-Ion Concentration; Isoenzymes; Lactic Acid; Mutation; NAD; NADH Dehydrogenase; Oxidation-Reduction; Pyruvic Acid; Saccharomyces cerevisiae | 1998 |
Changes in the redox state in the retina and brain during the onset of diabetes in rats.
Topics: Animals; Cerebral Cortex; Diabetes Mellitus, Experimental; L-Lactate Dehydrogenase; Lactic Acid; Lens, Crystalline; Liver; NAD; Oxidation-Reduction; Pigment Epithelium of Eye; Pyruvic Acid; Rats; Retina | 1998 |
[Effect of modulators of energy metabolism on cyclophosphane toxicity for Daphnia magna].
Topics: Alkylating Agents; Amino Acids; Animals; Biological Transport; Citric Acid; Cyclophosphamide; Daphnia; Energy Metabolism; Glucose; NAD; Niacinamide; Pyruvic Acid; Succinic Acid | 1998 |
Pantothenol protects rats against some deleterious effects of gamma radiation.
Topics: Animals; Antioxidants; beta Carotene; Cholesterol; Coenzyme A; Drug Administration Schedule; Female; Gamma Rays; Glutathione; Glutathione Disulfide; Intubation, Gastrointestinal; Lactic Acid; Lipids; Liver; Malate Dehydrogenase; Malate Dehydrogenase (NADP+); NAD; Pantothenic Acid; Phospholipids; Proteins; Pyruvic Acid; Radiation-Protective Agents; Rats; Rats, Inbred Strains; Reactive Oxygen Species; Thiobarbituric Acid Reactive Substances | 1998 |
Analysis of the structure and substrate binding of Phormidium lapideum alanine dehydrogenase.
Topics: Alanine; Alanine Dehydrogenase; Amino Acid Oxidoreductases; Amino Acid Sequence; Binding Sites; Catalysis; Crystallography, X-Ray; Cyanobacteria; Models, Molecular; Molecular Sequence Data; NAD; Protein Conformation; Pyruvic Acid | 1998 |
Activation of the plant alternative oxidase by high reduction levels of the Q-pool and pyruvate.
Topics: Blotting, Western; Dithiothreitol; Enzyme Activation; Glycine max; Magnoliopsida; Mitochondrial Proteins; NAD; Oxidation-Reduction; Oxidoreductases; Plant Proteins; Pyruvic Acid; Succinic Acid; Ubiquinone | 1998 |
Metabolic modulation of cellular redox potential can improve cardiac recovery from ischemia-reperfusion injury.
Topics: Animals; Aspartic Acid; Male; Myocardial Contraction; Myocardial Reperfusion Injury; Myocardium; NAD; Oxidation-Reduction; Pyruvic Acid; Rats; Rats, Sprague-Dawley; Xanthines | 1998 |
In vitro correlation between two colorimetric assays and the pyruvic acid consumption by fibroblasts cultured to determine the sodium laurylsulfate cytotoxicity.
Topics: Cells, Cultured; Colorimetry; Fibroblasts; Humans; NAD; Neutral Red; Pyruvic Acid; Sensitivity and Specificity; Sodium Dodecyl Sulfate; Surface-Active Agents; Tetrazolium Salts; Thiazoles | 1998 |
Oxidative phosphorylation in intact hepatocytes: quantitative characterization of the mechanisms of change in efficiency and cellular consequences.
Topics: 2,4-Dinitrophenol; Adenosine Triphosphatases; Adenosine Triphosphate; Almitrine; Animals; Caprylates; Cells, Cultured; Dihydroxyacetone; Lactic Acid; Male; Mitochondria, Liver; NAD; Oxidation-Reduction; Oxidative Phosphorylation; Proton Pumps; Pyruvic Acid; Rats; Rats, Wistar; Thermodynamics | 1998 |
Selective inhibitors of human lactate dehydrogenases and lactate dehydrogenase from the malarial parasite Plasmodium falciparum.
Topics: Animals; Enzyme Inhibitors; Humans; Kinetics; L-Lactate Dehydrogenase; Lactic Acid; NAD; Oxidation-Reduction; Plasmodium falciparum; Pyruvic Acid; Sesquiterpenes | 1998 |
Acute and chronic ethanol increases reactive oxygen species generation and decreases viability in fresh, isolated rat hepatocytes.
Topics: Alcohol Dehydrogenase; Animals; Cell Survival; Cyanamide; Enzyme Inhibitors; Ethanol; Fomepizole; Kinetics; Liver; Liver Diseases, Alcoholic; Male; Microsomes, Liver; NAD; Pyrazoles; Pyruvic Acid; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Xylitol | 1998 |
Role of NADH shuttle system in glucose-induced activation of mitochondrial metabolism and insulin secretion.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Aminooxyacetic Acid; Animals; Aspartate Aminotransferases; Calcium; Citric Acid Cycle; Enzyme Inhibitors; Female; Gene Targeting; Glucose; Glycerolphosphate Dehydrogenase; Glycolysis; Insulin; Insulin Secretion; Islets of Langerhans; Male; Membrane Potentials; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mitochondria; Models, Biological; Molecular Sequence Data; NAD; Pyruvic Acid | 1999 |
Kinetic, dynamic, and pathway studies of glycerol metabolism by Klebsiella pneumoniae in anaerobic continuous culture: IV. Enzymes and fluxes of pyruvate metabolism.
Topics: Acetyltransferases; Anaerobiosis; Citrate (si)-Synthase; Enzymes; Glycerol; Kinetics; Klebsiella pneumoniae; NAD; Pyruvate Dehydrogenase Complex; Pyruvate Kinase; Pyruvic Acid | 1998 |
NADH-Linked substrate-mediated enhancement of mitochondrial calcium accumulation and DNA single-strand breakage elicited by tert-butylhydroperoxide: the source of the cation is a ryanodine-sensitive calcium store.
Topics: Caffeine; Calcium; Calcium Signaling; DNA Damage; Humans; Mitochondria; NAD; Pyruvic Acid; Rotenone; Ryanodine; tert-Butylhydroperoxide; U937 Cells | 1999 |
A general method for relieving substrate inhibition in lactate dehydrogenases.
Topics: Enzyme Inhibitors; Escherichia coli; Humans; Kinetics; L-Lactate Dehydrogenase; Lactic Acid; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Molecular Structure; Mutagenesis, Site-Directed; Myocardium; NAD; Pyruvic Acid | 1999 |
Study of single-molecule dynamics and reactions with classic light microscopy.
Topics: Bacteriophage lambda; Deoxyribonucleases, Type II Site-Specific; DNA, Viral; L-Lactate Dehydrogenase; Lactic Acid; Microinjections; Microscopy, Fluorescence; NAD; NADP; Pyruvic Acid | 1999 |
Frequency-dependent fatigue development during electrical stimulation in the masseter muscle of pigtail monkeys.
Topics: Animals; Bite Force; Electric Stimulation; Electromyography; Female; Glucose; Glycogen; Lactic Acid; Macaca nemestrina; Male; Masseter Muscle; Muscle Fatigue; NAD; Phosphocreatine; Pyruvic Acid | 1998 |
Plant mitochondrial 2-oxoglutarate dehydrogenase complex: purification and characterization in potato.
Topics: Acyltransferases; Amino Acid Sequence; Arabidopsis; Blotting, Western; Cell Respiration; Chromatography, Gel; Citric Acid Cycle; Hydrogen-Ion Concentration; Ketoglutarate Dehydrogenase Complex; Ketoglutaric Acids; Mitochondria; Molecular Sequence Data; Molecular Weight; NAD; Plant Roots; Pyruvate Dehydrogenase Complex; Pyruvic Acid; Sequence Alignment; Sequence Homology, Amino Acid; Solanum tuberosum; Succinic Acid | 1999 |
The responses of rat hepatocytes to glucagon and adrenaline. Application of quantified elasticity analysis.
Topics: Adenosine Triphosphate; Animals; Epinephrine; Glucagon; Glucose; Glycolysis; Homeostasis; In Vitro Techniques; Kinetics; Lactic Acid; Liver; Liver Glycogen; Mitochondria, Liver; Models, Biological; NAD; Protons; Pyruvic Acid; Rats | 1999 |
Lactate regulates pyruvate uptake and metabolism in the preimplantation mouse embryo.
Topics: Animals; Blastocyst; Culture Media; Culture Techniques; Embryo, Mammalian; Embryonic Development; Female; Fluorescence; Glucose; Kinetics; L-Lactate Dehydrogenase; Lactic Acid; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; NAD; Oxidation-Reduction; Pregnancy; Pyruvic Acid; Zygote | 2000 |
Mechanisms of increased gluconeogenesis from alanine in rat isolated hepatocytes after endurance training.
Topics: Alanine; Animals; Biological Transport; Cell Separation; Gluconeogenesis; Liver; Male; NAD; Perfusion; Phosphoenolpyruvate; Physical Conditioning, Animal; Physical Endurance; Pyruvic Acid; Rats; Rats, Wistar; Reference Values | 2000 |
Marked differences between two isoforms of human pyruvate dehydrogenase kinase.
Topics: Acetyl Coenzyme A; Acetylation; Acetyltransferases; Binding Sites; Buffers; Dichloroacetic Acid; Dihydrolipoyllysine-Residue Acetyltransferase; Enzyme Activation; Enzyme Inhibitors; Humans; Isoenzymes; Kinetics; NAD; Protein Binding; Protein Kinases; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Pyruvate Dehydrogenase Complex; Pyruvic Acid; Recombinant Proteins | 2000 |
Zinc-induced cortical neuronal death: contribution of energy failure attributable to loss of NAD(+) and inhibition of glycolysis.
Topics: Animals; Cell Death; Cells, Cultured; Cerebral Cortex; Dihydroxyacetone Phosphate; Glyceraldehyde-3-Phosphate Dehydrogenases; Glycolysis; Mice; NAD; Neurons; Niacinamide; Pyruvic Acid; Zinc | 2000 |
Pyruvate secreted by human lymphoid cell lines protects cells from hydrogen peroxide mediated cell death.
Topics: Cell Death; Cell Line; Coumaric Acids; Culture Media; DNA Damage; Free Radical Scavengers; Humans; Hydrogen Peroxide; Jurkat Cells; Kinetics; L-Lactate Dehydrogenase; Lymphocytes; NAD; Pyruvic Acid; Reactive Oxygen Species | 2000 |
The cyanide-resistant alternative oxidases from the fungi Pichia stipitis and Neurospora crassa are monomeric and lack regulatory features of the plant enzyme.
Topics: Acids; Amino Acid Sequence; Cross-Linking Reagents; Cyanides; Dimerization; Disulfides; Electrophoresis, Polyacrylamide Gel; Freezing; Fungal Proteins; Gene Expression Regulation, Fungal; Gene Expression Regulation, Plant; Glycine max; Hydroquinones; Immunoblotting; Mitochondria; Models, Biological; Molecular Sequence Data; NAD; Neurospora crassa; Oxidation-Reduction; Oxidoreductases; Oxygen Consumption; Pichia; Plant Proteins; Protein Structure, Tertiary; Pyruvic Acid; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Succinic Acid | 2000 |
Effects of limited aeration and of the ArcAB system on intermediary pyruvate catabolism in Escherichia coli.
Topics: Acetyltransferases; Bacterial Outer Membrane Proteins; Cytochrome b Group; Cytochromes; Electron Transport Chain Complex Proteins; Escherichia coli; Escherichia coli Proteins; Glucose; Membrane Proteins; NAD; Oxidoreductases; Oxygen; Protein Kinases; Pyruvic Acid; Repressor Proteins | 2000 |
Age-dependent changes in glycosaminoglycan content in the skin of fasted rats. A possible mechanism.
Topics: Aging; Animals; Blood Glucose; Fasting; Glycosaminoglycans; Lactic Acid; Male; NAD; Pyruvic Acid; Rats; Rats, Wistar; Skin; Uronic Acids | 2000 |
New sequence data enable modelling of the fungal alternative oxidase and explain an absence of regulation by pyruvate.
Topics: Amino Acid Sequence; Binding Sites; Cloning, Molecular; Conserved Sequence; Cysteine; Dimerization; Fungi; Holoenzymes; Mitochondria; Mitochondrial Proteins; Models, Molecular; Molecular Sequence Data; NAD; Oxidation-Reduction; Oxidoreductases; Oxygen; Plant Proteins; Protein Structure, Secondary; Protein Structure, Tertiary; Pyruvic Acid; Sequence Alignment; Ubiquinone | 2000 |
Lysine 199 is the general acid in the NAD-malic enzyme reaction.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; Arginine; Ascaris suum; Catalysis; Conserved Sequence; Hydrogen-Ion Concentration; Kinetics; Lysine; Malate Dehydrogenase; Molecular Sequence Data; Mutagenesis, Site-Directed; NAD; Oxaloacetic Acid; Pyruvic Acid; Solvents; Tritium | 2000 |
Glycolytic enzyme activity in hypotonically treated boar spermatozoa.
Topics: Adenosine Diphosphate; Animals; Buffers; Dihydroxyacetone Phosphate; Fructosediphosphates; Glyceraldehyde 3-Phosphate; Glyceric Acids; Glycolysis; Hypotonic Solutions; L-Lactate Dehydrogenase; Lactic Acid; Male; NAD; Phosphates; Phosphofructokinase-1; Pyruvic Acid; Spermatozoa; Swine | 1999 |
Intracellular fluxes in a recombinant xylose-utilizing Saccharomyces cerevisiae cultivated anaerobically at different dilution rates and feed concentrations.
Topics: Aldehyde Reductase; Anaerobiosis; Biomass; Citric Acid Cycle; Culture Media; Ethanol; Glucose; Models, Biological; NAD; Pentose Phosphate Pathway; Pyruvic Acid; Saccharomyces cerevisiae; Xylose | 2001 |
Inhibitory effect of sorbitol on sugar metabolism of Streptococcus mutans in vitro and on acid production in dental plaque in vivo.
Topics: Acetic Acid; Acetyltransferases; Adult; Aged; Dental Plaque; Female; Formates; Glucose; Glyceraldehyde-3-Phosphate Dehydrogenases; Glycolysis; Humans; Hydrogen-Ion Concentration; Ion-Selective Electrodes; Lactic Acid; Middle Aged; NAD; Oxygen; Pyruvic Acid; Sorbitol; Streptococcus mutans; Sucrose | 2001 |
Diabetes-induced changes in retinal NAD-redox status: pharmacological modulation and implications for pathogenesis of diabetic retinopathy.
Topics: Adrenergic alpha-Antagonists; Ammonia; Animals; Antioxidants; Cell Fractionation; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Fructose; Glucose; Glutamic Acid; Imidazoles; Imidazolidines; Ketoglutaric Acids; Lactic Acid; Male; Mitochondria; NAD; Oxidation-Reduction; Piperazines; Prazosin; Pyrimidines; Pyruvic Acid; Rats; Rats, Sprague-Dawley; Retina; Sorbitol; Thioctic Acid | 2001 |
Rates of gluconeogenesis in perfused liver of alloxan-diabetic fed rats.
Topics: Alloxan; Animals; Diabetes Mellitus, Experimental; Fructose; Gluconeogenesis; Glucose; Glutamine; In Vitro Techniques; Kinetics; Lactic Acid; Liver; Male; NAD; Perfusion; Pyruvic Acid; Rats; Rats, Wistar; Uric Acid | 2000 |
Standard apparent reduction potentials for biochemical half reactions as a function of pH and ionic strength.
Topics: Acetone; Coenzyme A; Cytochrome c Group; Ferredoxins; Flavin Mononucleotide; Glutathione; Hydrogen; Hydrogen-Ion Concentration; Methane; NAD; Nitrogen; Nitrogenase; Osmolar Concentration; Oxidation-Reduction; Oxygen; Oxygenases; Pyruvic Acid; Reference Values; Retinaldehyde; Thermodynamics | 2001 |
NADH: sensor of blood flow need in brain, muscle, and other tissues.
Topics: Animals; Brain; Cytosol; Lactic Acid; Muscle Contraction; Muscles; NAD; Physical Conditioning, Animal; Pyruvic Acid; Rats; Regional Blood Flow; Seizures; Signal Transduction; Vibrissae | 2001 |
Structural analyses of a malate dehydrogenase with a variable active site.
Topics: Binding Sites; Crystallography; Malate Dehydrogenase; Models, Structural; NAD; Protein Conformation; Pyruvic Acid | 2001 |
Allosteric activation of pyruvate kinase via NAD+ in rat liver cells.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Allosteric Regulation; Animals; Cell Separation; Dihydroxyacetone Phosphate; Energy Metabolism; Lactic Acid; Liver; Male; NAD; Niacinamide; Phosphoenolpyruvate; Pyruvate Kinase; Pyruvic Acid; Rats; Rats, Wistar | 2001 |
Is ischemia involved in the pathogenesis of murine cerebral malaria?
Topics: Adenosine Triphosphate; Alanine; Amino Acids; Animals; Brain; Brain Ischemia; Chromatography, High Pressure Liquid; Female; In Vitro Techniques; Lactic Acid; Magnetic Resonance Spectroscopy; Malaria, Cerebral; Mice; Mice, Inbred CBA; NAD; Osmolar Concentration; Pyruvic Acid | 2001 |
Mitochondrial metabolism sets the maximal limit of fuel-stimulated insulin secretion in a model pancreatic beta cell: a survey of four fuel secretagogues.
Topics: Adenosine Triphosphate; Adenoviridae; Animals; Calcium; Cell Line; Cell Membrane; Cytosol; Dihydroxyacetone; Dose-Response Relationship, Drug; Glucose; Glycerol Kinase; Glycolysis; Humans; Hydrogen; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Membrane Potentials; Mitochondria; NAD; Oxidation-Reduction; Oxygen; Perchlorates; Perfusion; Phosphorylation; Pyruvic Acid; Rats; Substrate Specificity; Thermodynamics; Time Factors | 2002 |
Insulin increases NADH/NAD+ redox state, which stimulates guanylate cyclase in vascular smooth muscle.
Topics: Animals; Cells, Cultured; Cyclic GMP; Dogs; Guanylate Cyclase; Indazoles; Insulin; Isocitrates; Lactic Acid; Muscle, Smooth, Vascular; NAD; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxaloacetic Acid; Oxidation-Reduction; Pyruvic Acid; Stimulation, Chemical | 2002 |
Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration.
Topics: Adenosine Triphosphate; Animals; Carbon; Carbon Dioxide; Cell Respiration; Cellular Senescence; Citric Acid Cycle; Cyclic AMP-Dependent Protein Kinases; Electron Transport; Energy Intake; Fermentation; Gene Expression Profiling; Gluconeogenesis; Glucose; Glycolysis; Histone Deacetylases; Longevity; Mitochondria; Mutation; NAD; Oxidative Stress; Oxygen Consumption; Pyruvic Acid; Saccharomyces cerevisiae; Silent Information Regulator Proteins, Saccharomyces cerevisiae; Sirtuin 2; Sirtuins; Trans-Activators | 2002 |
Tricarboxylic acid cycle substrates prevent PARP-mediated death of neurons and astrocytes.
Topics: Animals; Animals, Newborn; Astrocytes; Cell Death; Cells, Cultured; Citric Acid Cycle; Coculture Techniques; Enzyme Activation; Glycolysis; Ketoglutaric Acids; Methylnitronitrosoguanidine; Mice; NAD; Neurons; Poly(ADP-ribose) Polymerases; Pyruvic Acid | 2002 |
Phosphite dehydrogenase: a versatile cofactor-regeneration enzyme.
Topics: Kinetics; L-Lactate Dehydrogenase; Lactic Acid; NAD; NADH, NADPH Oxidoreductases; NADP; Pyruvic Acid; Thermodynamics | 2002 |
Pyruvate improves redox status and decreases indicators of hepatic apoptosis during hemorrhagic shock in swine.
Topics: Acid-Base Equilibrium; Animals; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Blood Pressure; Caspases; Glutathione; Glutathione Disulfide; Lactic Acid; Liver; Microdialysis; Mitochondria; NAD; NADP; Osmolar Concentration; Oxidation-Reduction; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Pyruvic Acid; Shock, Hemorrhagic; Swine | 2002 |
Modeling biochemical aspects of energy metabolism in mammals.
Topics: Adenosine Triphosphate; Amino Acids; Animals; Dietary Fats; Dietary Proteins; Energy Metabolism; Flavin-Adenine Dinucleotide; Glucose; Lipid Metabolism; Lipids; Mammals; Models, Biological; NAD; NADP; Oxidation-Reduction; Pyruvic Acid | 2002 |
CYP119 plus a Sulfolobus tokodaii strain 7 ferredoxin and 2-oxoacid:ferredoxin oxidoreductase constitute a high-temperature cytochrome P450 catalytic system.
Topics: Archaeal Proteins; Catalysis; Cytochrome P-450 Enzyme System; Ferredoxins; Ketone Oxidoreductases; Kinetics; Lauric Acids; NAD; NADP; Oxygenases; Pyruvic Acid; Sulfolobus | 2002 |
Changes in actomyosin ATP consumption rate in rat diaphragm muscle fibers during postnatal development.
Topics: Actomyosin; Adenosine Triphosphatases; Adenosine Triphosphate; Aging; Algorithms; Animals; Body Weight; Diaphragm; Isomerism; Kinetics; L-Lactate Dehydrogenase; Male; Muscle Fatigue; Muscle Fibers, Skeletal; Myosin Heavy Chains; NAD; Pyruvic Acid; Rats; Rats, Sprague-Dawley | 2003 |
Cytoprotection of pyruvic acid and reduced beta-nicotinamide adenine dinucleotide against hydrogen peroxide toxicity in neuroblastoma cells.
Topics: Animals; Antioxidants; Brain Neoplasms; Cell Survival; Glycolysis; Hydrogen Peroxide; Kinetics; Mice; Models, Biological; NAD; Neuroblastoma; Oxidation-Reduction; Phosphoenolpyruvate; Pyruvic Acid; Tumor Cells, Cultured | 2003 |
Pyruvate inhibits zinc-mediated pancreatic islet cell death and diabetes.
Topics: Adenosine Triphosphate; Animals; Antigens, Polyomavirus Transforming; Antioxidants; Cell Death; Cell Line, Tumor; Cell Transformation, Neoplastic; Diabetes Mellitus, Experimental; Etoposide; Insulinoma; Interferon-gamma; Islets of Langerhans; NAD; Necrosis; Pancreatic Neoplasms; Pyruvic Acid; Rats; Rats, Sprague-Dawley; Staurosporine; Tumor Necrosis Factor-alpha; Zinc | 2003 |
Rôle of coenzyme A and diphosphopyridine nucleotide in the oxidation of pyruvate.
Topics: Coenzyme A; Coenzymes; NAD; Oxidation-Reduction; Pyruvates; Pyruvic Acid | 1952 |
The thermodynamics of the reaction of pyruvic acid with reduced diphosphopyridine nucleotide.
Topics: Coenzymes; NAD; Pyruvates; Pyruvic Acid; Thermodynamics | 1955 |
[Changes of alpha-ketoglutaric acid, pyruvic acid and diphosphopyridine nucleotide in chronic liver diseases].
Topics: Coenzymes; Glutarates; Humans; Ketoglutaric Acids; Liver Cirrhosis; Liver Diseases; NAD; Pyruvates; Pyruvic Acid | 1957 |
Evidence for ternary-complex formation with rabbit-muscle lactic acid dehydrogenase, diphosphopyridine nucleotide and pyruvic acid.
Topics: Animals; Coenzymes; L-Lactate Dehydrogenase; Lactate Dehydrogenases; Lactic Acid; Muscles; NAD; Oxidoreductases; Pyruvates; Pyruvic Acid; Rabbits | 1961 |
Enzymes of glucose and pyruvate catabolism in cells, spores, and germinated spores of Clostridium botulinum.
Topics: Carbohydrate Metabolism; Clostridium botulinum; Fermentation; Glucose; NAD; Oxidoreductases; Protein Hydrolysates; Pyruvates; Pyruvic Acid; Spores, Bacterial | 1962 |
[COMPARATIVE STUDIES ON THE REDUCTION OF PYRUVATE, HYDROXYPYRUVATE AND GLYOXYLATE BY NAD-OXIDOREDUCTASES OF LACTATE DEHYDROGENASE, GLOXYLATE REDUCTASE AND D-GLYCERATE DEHYDROGENASE].
Topics: Carbohydrate Dehydrogenases; Glyoxylates; L-Lactate Dehydrogenase; NAD; Oxidoreductases; Plants; Pyruvates; Pyruvic Acid | 1963 |
FERREDOXIN LINKED DPN REDUCTION BY PYRUVATE IN EXTRACTS OF CLOSTRIDIUM ACIDI-URICI.
Topics: Clostridium; Ferredoxins; Iron; Metabolism; NAD; Pyruvates; Pyruvic Acid; Research | 1963 |
FAILURE OF ARSENATE TO UNCOUPLE THE PHOSPHOTRANSACETYLASE SYSTEM IN CLOSTRIDIUM ACIDIURICI.
Topics: Acetyl Coenzyme A; Acetylesterase; Arsenates; Arsenicals; Clostridium; Coenzyme A; Metabolism; NAD; Pharmacology; Phosphate Acetyltransferase; Phosphates; Phosphorus Isotopes; Pyruvates; Pyruvic Acid; Radiometry; Research; Utah | 1963 |
INHIBITION OF TUMOR CELL GLYCOLYSIS BY DPNH2, AND REVERSAL OF THE INHIBITION BY DPN, PYRUVATE OR METHYLENE BLUE.
Topics: Animals; Carbohydrate Metabolism; Carcinoma, Ehrlich Tumor; Carcinoma, Krebs 2; Glycolysis; Melanoma; Methylene Blue; Mice; NAD; NADP; Neoplasms, Experimental; Niacin; Niacinamide; Pharmacology; Pyruvates; Pyruvic Acid; Research | 1963 |
BLOOD LACTATE, PYRUVATE AND LACTATE-PYRUVATE RATIOS IN CONGENITAL HEART DISEASE.
Topics: Blood Chemical Analysis; Child; Heart Defects, Congenital; Humans; Hypoxia; Lactates; Lactic Acid; NAD; Oximetry; Pyruvates; Pyruvic Acid | 1964 |
INSTABILITY OF PYRUVATE-C-14 IN AQUEOUS SOLUTION AS DETECTED BY ENZYMIC ASSAY.
Topics: Carbon Isotopes; Chemical Precipitation; Hydrochloric Acid; L-Lactate Dehydrogenase; Lactates; NAD; Phenylhydrazines; Pyruvates; Pyruvic Acid; Research; Sodium Chloride; Solutions; Surface-Active Agents | 1964 |
LACTATE-DEGRADING SYSTEM IN BUTYRIBACTERIUM RETTGERI SUBJECT TO GLUCOSE REPRESSION.
Topics: Culture Media; Eubacterium; Fructose; Glucose; L-Lactate Dehydrogenase; Lactates; Lactic Acid; Metabolism; NAD; Oxidation-Reduction; Oxidoreductases; Pyruvates; Pyruvic Acid; Research; Thioctic Acid; United States | 1964 |
PYRUVATE AND LACTATE LEVELS IN RELATIONSHIP TO THE NICOTINAMIDE--ADENINE DINUCLEOTIDE LEVELS IN MALARIAL PARASITES (PLASMODIUM BERGHEI).
Topics: Adenine; Animals; Erythrocytes; Glucose; L-Lactate Dehydrogenase; Lactates; Lactic Acid; N-Glycosyl Hydrolases; NAD; Niacinamide; Parasites; Phenylhydrazines; Plasmodium; Plasmodium berghei; Pyruvates; Pyruvic Acid; Rats; Research; Reticulocytes | 1964 |
GLYCOLYTIC CONTROL MECHANISMS. I. INHIBITION OF GLYCOLYSIS BY ACETATE AND PYRUVATE IN THE ISOLATED, PERFUSED RAT HEART.
Topics: Acetates; Carbohydrate Metabolism; Citrates; Feedback; Glucose; Glycolysis; Hexosephosphates; Insulin; Keto Acids; Myocardium; NAD; Perfusion; Pharmacology; Pyruvates; Pyruvic Acid; Rats; Research; Spectrophotometry | 1965 |
THE UTILIZATION OF ACONATE AND ITACONATE BY MICROCOCCUS SP.
Topics: Acetyl Coenzyme A; Aldehydes; Carbon Dioxide; Citric Acid Cycle; Coenzyme A; L-Lactate Dehydrogenase; Metabolism; Micrococcus; NAD; NADP; Oxidoreductases; Pyruvates; Pyruvic Acid; Research; Spectrophotometry; Succinates; Succinic Acid | 1965 |
THE OVERALL IN VITRO SYNTHESIS OF VALINE FROM PYRUVATE BY NEUROSPORA HOMOGENATES.
Topics: Amino Acids; Calcium; Edetic Acid; Hydro-Lyases; Hydrogen-Ion Concentration; In Vitro Techniques; Isomerases; Keto Acids; Lyases; Magnesium; NAD; Neurospora; Pyruvates; Pyruvic Acid; Research; Sucrose; Thiamine Pyrophosphate; Transaminases; Valine | 1965 |
NADH augments blood flow in physiologically activated retina and visual cortex.
Topics: Animals; Energy Metabolism; Lactic Acid; Male; NAD; NG-Nitroarginine Methyl Ester; Pyruvic Acid; Rats; Rats, Sprague-Dawley; Retinal Vessels; Visual Cortex | 2004 |
Structure of Toxoplasma gondii LDH1: active-site differences from human lactate dehydrogenases and the structural basis for efficient APAD+ use.
Topics: Animals; Apoenzymes; Binding Sites; Catalysis; Coenzymes; Crystallography, X-Ray; Enzyme Inhibitors; Humans; Isoenzymes; L-Lactate Dehydrogenase; Lactic Acid; Muscle, Skeletal; Myocardium; NAD; Oxalic Acid; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Pyruvic Acid; Substrate Specificity; Toxoplasma | 2004 |
Glycogen metabolism in the rat retina.
Topics: Animals; Darkness; Dose-Response Relationship, Drug; Glucose; Glycogen; In Vitro Techniques; Lactic Acid; Light; NAD; Pyruvic Acid; Rats; Rats, Long-Evans; Retina; Time Factors | 2004 |
Activation of pyruvate oxidation in tumor mitochondria by diphosphopyridine nucleotide.
Topics: Biochemical Phenomena; Coenzymes; Mitochondria; NAD; Neoplasms; Oxidation-Reduction; Pyruvates; Pyruvic Acid | 1951 |
Heterogenic response of the liver parenchyma to ethanol studied in the bivascularly perfused rat liver.
Topics: Animals; Carbon Dioxide; Citric Acid Cycle; Ethanol; Gluconeogenesis; Glucose; Glycolysis; Lactic Acid; Liver; Liver Glycogen; Male; NAD; Oxidation-Reduction; Oxygen Consumption; Perfusion; Pyruvic Acid; Rats; Rats, Wistar | 2004 |
Protection by pyruvate of rat retinal cells against zinc toxicity in vitro, and pressure-induced ischemia in vivo.
Topics: Adenosine Triphosphate; Animals; Cell Culture Techniques; Cell Survival; Chlorides; Cytoprotection; Disease Models, Animal; Intraocular Pressure; Microscopy, Fluorescence; NAD; Neurons, Afferent; Neuroprotective Agents; Poly(ADP-ribose) Polymerases; Pyruvic Acid; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Retinal Degeneration; Zinc Compounds | 2004 |
Effect of coenzyme Q10 on the mitochondrial function of skin fibroblasts from Parkinson patients.
Topics: Adenosine Diphosphate; Adult; Aged; Amobarbital; Antioxidants; Cells, Cultured; Coenzymes; Drug Interactions; Female; Fibroblasts; Glutamic Acid; Humans; Male; Middle Aged; Mitochondria; NAD; Oxygen; Parkinson Disease; Pyruvic Acid; Skin; Ubiquinone | 2004 |
Absence of NADH channeling in coupled reaction of mitochondrial malate dehydrogenase and complex I in alamethicin-permeabilized rat liver mitochondria.
Topics: Alamethicin; Animals; Cell Compartmentation; Cell Membrane Permeability; Electron Transport Complex I; Glutamates; Intracellular Membranes; Malate Dehydrogenase; Malates; Mitochondria, Liver; NAD; Oxidation-Reduction; Oxygen Consumption; Pyruvic Acid; Rats; Uncoupling Agents | 2004 |
Quantitative NAD(P)H/flavoprotein autofluorescence imaging reveals metabolic mechanisms of pancreatic islet pyruvate response.
Topics: Animals; Dihydrolipoamide Dehydrogenase; Electron-Transferring Flavoproteins; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Mitochondria; NAD; NADP; Pyruvates; Pyruvic Acid | 2004 |
Computational studies of the effects of myocardial blood flow reductions on cardiac metabolism.
Topics: Adenosine Triphosphate; Glycogen; Glycolysis; Lactic Acid; Models, Cardiovascular; Myocardial Ischemia; Myocardium; NAD; Oxidation-Reduction; Oxygen Consumption; Phosphocreatine; Phosphorylation; Pyruvic Acid | 2004 |
Enabling multienzyme biocatalysis using nanoporous materials.
Topics: Catalysis; Cross-Linking Reagents; Enzymes, Immobilized; Glucose; Glucose 1-Dehydrogenase; Glutaral; Kinetics; L-Lactate Dehydrogenase; Multienzyme Complexes; NAD; Nanostructures; Polyethylene Glycols; Polystyrenes; Propylamines; Pyruvic Acid; Serum Albumin, Bovine; Silanes; Silicon Dioxide; Surface Properties | 2004 |
Metabolic analysis of Corynebacterium glutamicum during lactate and succinate productions under oxygen deprivation conditions.
Topics: Acids; Anaerobiosis; Corynebacterium; DNA, Bacterial; Gene Deletion; Gene Dosage; Genes, Bacterial; Glucose; L-Lactate Dehydrogenase; Lactic Acid; Molecular Sequence Data; Mutagenesis, Insertional; Mutation; NAD; Phosphoenolpyruvate Carboxylase; Pyruvic Acid; Sequence Analysis, DNA; Sodium Bicarbonate; Succinic Acid | 2004 |
Cytosolic NADH redox and thiol oxidation regulate pulmonary arterial force through ERK MAP kinase.
Topics: Animals; Cattle; Cell Hypoxia; Cytosol; Diamide; Enzyme Activation; Enzyme Inhibitors; Hydrogen Peroxide; L-Lactate Dehydrogenase; Lactic Acid; Mitogen-Activated Protein Kinases; NAD; NADPH Oxidases; Oxidants; Oxidation-Reduction; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pulmonary Artery; Pyruvic Acid; Signal Transduction; Stress, Mechanical; Sulfhydryl Compounds | 2005 |
Constructing biological pathway models with hybrid functional Petri nets.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Galactose; Glucose; Glycolysis; Hydrolysis; Lac Operon; Lactose; Models, Biological; NAD; Pyruvic Acid; Transcription, Genetic | 2004 |
[Effect of intermittent hypoxic training on indices of adaptation to hypoxia in rats during physical exertion].
Topics: Adaptation, Physiological; Animals; Hypoxia; Lactic Acid; Male; Mitochondria, Muscle; Muscle, Skeletal; NAD; Oxidative Phosphorylation; Oxygen Consumption; Physical Exertion; Pyruvic Acid; Rats; Rats, Wistar; Succinate Dehydrogenase | 2004 |
Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1.
Topics: Acetylation; Animals; Caloric Restriction; Cyclic AMP; Fasting; Gene Expression Regulation; Gluconeogenesis; Glucose; Glycolysis; Hepatocytes; Homeostasis; Insulin; Lactic Acid; Liver; Longevity; Lysine; Mice; NAD; Nutritional Status; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Protein Binding; Pyruvic Acid; Rats; RNA, Messenger; Sirtuin 1; Sirtuins; Trans-Activators; Transcription Factors | 2005 |
Metabolic network analysis of Streptomyces tenebrarius, a Streptomyces species with an active entner-doudoroff pathway.
Topics: Aminoglycosides; Anti-Bacterial Agents; Base Sequence; Carbon; Citric Acid Cycle; Computer Simulation; Glucose; Glycolysis; Molecular Sequence Data; NAD; NADP; Pyruvic Acid; Streptomyces | 2005 |
Pyruvate but not lactate prevents NADH-induced myoglobin oxidation.
Topics: Animals; Antioxidants; Catalase; Dose-Response Relationship, Drug; Free Radicals; Horses; Hydrogen Peroxide; Hydrogen-Ion Concentration; Kinetics; Lactates; Lactic Acid; Myocardium; Myoglobin; NAD; Oxidation-Reduction; Oxygen; Pyruvic Acid; Reperfusion Injury; Time Factors | 2005 |
[The decrease of the activity of electron transfer chain of Torulopsis glabrata enhanced pyruvate productivity].
Topics: Acetaldehyde; Adenosine Triphosphatases; Adenosine Triphosphate; Candida glabrata; Electron Transport; Fermentation; Mutation; NAD; Pyruvic Acid | 2004 |
Homogeneous enzymatic assay for L-cysteine with betaC-S lyase.
Topics: Calibration; Cystathionine gamma-Lyase; Cysteine; Humans; L-Lactate Dehydrogenase; NAD; Pyruvic Acid; Reproducibility of Results; Streptococcus anginosus | 2005 |
Interference and blood sample preparation for a pyruvate enzymatic assay.
Topics: Adult; Blood Chemical Analysis; Female; Humans; L-Lactate Dehydrogenase; Lactic Acid; Male; Middle Aged; NAD; Perchlorates; Pyruvic Acid | 2006 |
Redirection of the NADH oxidation pathway in Torulopsis glabrata leads to an enhanced pyruvate production.
Topics: Adenosine Triphosphate; Candida glabrata; Fermentation; Glycolysis; Mutagenesis; NAD; Oxidation-Reduction; Oxidative Phosphorylation; Pyruvic Acid; Signal Transduction | 2006 |
Enhancement of pyruvate productivity in Torulopsis glabrata: Increase of NAD+ availability.
Topics: Biological Availability; Candida glabrata; Cell Culture Techniques; Genetic Enhancement; NAD; Pyruvic Acid | 2006 |
Reexamining the hyperglycemic pseudohypoxia hypothesis of diabetic oculopathy.
Topics: Adenosine Triphosphate; Aldehyde Reductase; Animals; Cell Culture Techniques; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Epithelial Cells; Glucose; Humans; Hyperglycemia; Hypoxia; Lactic Acid; Lens, Crystalline; NAD; Pigment Epithelium of Eye; Pyruvic Acid; Rabbits; Rats; Rats, Sprague-Dawley; Retina | 2006 |
Insulin-stimulated NADH/NAD+ redox state increases NAD(P)H oxidase activity in cultured rat vascular smooth muscle cells.
Topics: Angiotensin II; Animals; Aorta, Thoracic; Cell Movement; Cells, Cultured; Drug Synergism; Enzyme Activation; Hypoglycemic Agents; Insulin; Lactic Acid; Male; Muscle, Smooth, Vascular; NAD; NADPH Oxidases; Oxidation-Reduction; Pyruvic Acid; Rats; Rats, Sprague-Dawley; Vasoconstrictor Agents | 2006 |
Pyruvate improves recovery after PARP-1-associated energy failure induced by oxidative stress in neonatal rat cerebrocortical slices.
Topics: Animals; Animals, Newborn; Blotting, Western; Cell Survival; Cerebral Cortex; Citric Acid Cycle; Energy Metabolism; Glycolysis; Immunohistochemistry; In Situ Hybridization; In Situ Nick-End Labeling; In Vitro Techniques; Magnetic Resonance Spectroscopy; NAD; Oxidative Stress; Perchlorates; Poly (ADP-Ribose) Polymerase-1; Poly Adenosine Diphosphate Ribose; Poly(ADP-ribose) Polymerases; Pyruvic Acid; Rats; Rats, Sprague-Dawley | 2007 |
Redox sensor CtBP mediates hypoxia-induced tumor cell migration.
Topics: Alcohol Oxidoreductases; Biosensing Techniques; Cadherins; Cell Movement; DNA-Binding Proteins; Gene Expression Regulation, Neoplastic; Humans; Hypoxia; NAD; Neoplasm Metastasis; Oxidation-Reduction; Phosphoproteins; Promoter Regions, Genetic; Pyruvic Acid; Repressor Proteins; RNA, Small Interfering; Tumor Cells, Cultured | 2006 |
Elevated lactate suppresses neuronal firing in vivo and inhibits glucose metabolism in hippocampal slice cultures.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Dose-Response Relationship, Drug; Down-Regulation; Drug Interactions; Energy Metabolism; Glucose; Hippocampus; Lactic Acid; Male; NAD; Neurons; Organ Culture Techniques; Oxidation-Reduction; Oxidative Phosphorylation; Pyramidal Cells; Pyruvic Acid; Rats; Rats, Long-Evans; Synaptic Transmission; Up-Regulation | 2006 |
Redistribution of carbon flux in Torulopsis glabrata by altering vitamin and calcium level.
Topics: Biotin; Calcium; Candida glabrata; Carbon; Fermentation; Ketoglutaric Acids; NAD; Pyruvic Acid; Thiamine; Vitamins | 2007 |
Regulation of redox metabolism in the mouse oocyte and embryo.
Topics: Animals; Cytosol; Embryo, Mammalian; Embryonic Development; Female; Fertilization; Flavin-Adenine Dinucleotide; Glucose; Glutathione; In Vitro Techniques; Lactic Acid; Mice; Microscopy, Confocal; Mitochondria; Models, Biological; NAD; NADP; Oocytes; Oxidation-Reduction; Pregnancy; Pyruvic Acid | 2007 |
Effect of FPS1 deletion on the fermentation properties of Saccharomyces cerevisiae.
Topics: Fermentation; Glycerol; Membrane Proteins; NAD; Pyruvic Acid; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2007 |
Systemic pyruvate administration markedly reduces infarcts and motor deficits in rat models of transient and permanent focal cerebral ischemia.
Topics: Animals; Brain; Brain Chemistry; Brain Ischemia; Cell Death; Cerebral Infarction; Dose-Response Relationship, Drug; In Situ Nick-End Labeling; Ischemic Attack, Transient; Laser-Doppler Flowmetry; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; NAD; Psychomotor Performance; Pyruvic Acid; Rats; Rats, Sprague-Dawley | 2007 |
PdhR (pyruvate dehydrogenase complex regulator) controls the respiratory electron transport system in Escherichia coli.
Topics: Artificial Gene Fusion; Base Sequence; Consensus Sequence; DNA Footprinting; DNA-Binding Proteins; DNA, Bacterial; Electron Transport; Electron Transport Complex IV; Electrophoretic Mobility Shift Assay; Escherichia coli; Escherichia coli Proteins; Gene Expression Regulation, Bacterial; Genes, Reporter; Green Fluorescent Proteins; Luminescent Proteins; Molecular Sequence Data; NAD; NADH Dehydrogenase; Oxidation-Reduction; Oxygen; Promoter Regions, Genetic; Protein Binding; Pyruvic Acid; Red Fluorescent Protein; Repressor Proteins; Transcription Factors | 2007 |
Pyocyanin alters redox homeostasis and carbon flux through central metabolic pathways in Pseudomonas aeruginosa PA14.
Topics: Carbon; Cytoplasm; Gene Deletion; Metabolic Networks and Pathways; Models, Biological; NAD; Oxidation-Reduction; Pseudomonas aeruginosa; Pyocyanine; Pyruvic Acid | 2007 |
Metabolic engineering of Bacillus subtilis for ethanol production: lactate dehydrogenase plays a key role in fermentative metabolism.
Topics: Bacillus subtilis; Bacterial Proteins; Butylene Glycols; Ethanol; Fermentation; Gene Deletion; Genes, Bacterial; Genetic Vectors; L-Lactate Dehydrogenase; Lactic Acid; Models, Biological; Models, Genetic; NAD; NADP; Pyruvic Acid | 2007 |
Purification and three-dimensional electron microscopy structure of the Neisseria meningitidis type IV pilus biogenesis protein PilG.
Topics: Bacterial Proteins; Chromatography, Affinity; Cloning, Molecular; Dimerization; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Fimbriae Proteins; Gene Expression; Image Processing, Computer-Assisted; Microscopy, Electron, Transmission; Models, Molecular; NAD; Negative Staining; Neisseria meningitidis; Protein Structure, Tertiary; Pyruvic Acid; Recombinant Proteins | 2007 |
Reaction coordinate of an enzymatic reaction revealed by transition path sampling.
Topics: Binding Sites; Computer Simulation; Humans; Lactate Dehydrogenases; Models, Molecular; NAD; Probability; Protein Structure, Tertiary; Pyruvic Acid | 2007 |
Transformation products of extracellular NAD(+) in the rat liver: kinetics of formation and metabolic action.
Topics: Adenosine Diphosphate Ribose; Animals; Glucose; Infusion Pumps; Inosine; Liver; Male; NAD; Niacinamide; Pyruvic Acid; Rats; Rats, Wistar; Time Factors; Uric Acid | 2008 |
Enzymatic assay of D-serine using D-serine dehydratase from Saccharomyces cerevisiae.
Topics: Alanine Racemase; Chromatography, High Pressure Liquid; Humans; Hydro-Lyases; L-Lactate Dehydrogenase; NAD; Pyruvic Acid; Saccharomyces cerevisiae; Serine; Serum Albumin, Bovine; Spectrophotometry; Stereoisomerism | 2007 |
Different effects of monocarboxylates on neuronal survival and beta-amyloid toxicity.
Topics: Aconitate Hydratase; Adenosine Triphosphate; Amyloid beta-Peptides; Analysis of Variance; Animals; Animals, Newborn; Cell Survival; Drug Interactions; Glucose; Hippocampus; Lactic Acid; NAD; Neurons; Organ Culture Techniques; Pyruvic Acid; Rats; Rats, Wistar; Time Factors | 2007 |
Inhibition of agouti-related peptide expression by glucose in a clonal hypothalamic neuronal cell line is mediated by glycolysis, not oxidative phosphorylation.
Topics: Adenosine Triphosphate; Agouti-Related Protein; AMP-Activated Protein Kinases; Animals; Cell Line; Deoxyglucose; Drug Interactions; Enzyme Inhibitors; Gene Expression Regulation; Glucosamine; Glucose; Glyceraldehyde-3-Phosphate Dehydrogenases; Glycolysis; Hexosamines; Hypothalamus; Iodoacetates; Ketone Bodies; Mice; Multienzyme Complexes; NAD; Neurons; Oxidative Phosphorylation; Pentose Phosphate Pathway; Protein Serine-Threonine Kinases; Pyruvic Acid; RNA Interference | 2008 |
Pyruvate-sensitive AOX exists as a non-covalently associated dimer in the homeothermic spadix of the skunk cabbage, Symplocarpus renifolius.
Topics: Amino Acid Sequence; Araceae; Blotting, Western; Carboxylic Acids; Cell Respiration; Diamide; Dimerization; Dithiothreitol; Flowers; Gene Expression Regulation, Plant; Ketoglutaric Acids; Mitochondria; Mitochondrial Proteins; Molecular Sequence Data; NAD; Oxidation-Reduction; Oxidoreductases; Plant Proteins; Pyruvic Acid; RNA, Messenger; Submitochondrial Particles; Temperature | 2007 |
On the requirement for diphosphopyridine nucleotide in the aerobic metabolism of pyruvate by brain tissue.
Topics: Brain; Cell Respiration; NAD; Nucleotides; Pyruvates; Pyruvic Acid; Tissues | 1949 |
Three-dimensional structures of apo- and holo-L-alanine dehydrogenase from Mycobacterium tuberculosis reveal conformational changes upon coenzyme binding.
Topics: Alanine Dehydrogenase; Apoenzymes; Catalysis; Coenzymes; Enzyme Activation; Holoenzymes; Imaging, Three-Dimensional; Models, Biological; Models, Molecular; Mutagenesis, Site-Directed; Mycobacterium tuberculosis; NAD; Protein Binding; Protein Structure, Quaternary; Protein Subunits; Pyruvic Acid | 2008 |
The action of extracellular NAD+ in the liver of healthy and tumor-bearing rats: model analysis of the tumor-induced modified response.
Topics: Animals; Cachexia; Carcinoma 256, Walker; Eicosanoids; Extracellular Fluid; Glucose; Hemodynamics; Indomethacin; Lactic Acid; Liver; Male; Models, Biological; NAD; Oxygen Consumption; Protein Synthesis Inhibitors; Pyruvic Acid; Rats; Rats, Wistar | 2008 |
Reverse reaction of malic enzyme for HCO3- fixation into pyruvic acid to synthesize L-malic acid with enzymatic coenzyme regeneration.
Topics: Alginates; Carbon Dioxide; Glucosephosphate Dehydrogenase; Glucuronic Acid; Hexuronic Acids; Malate Dehydrogenase; Malates; NAD; Oxidation-Reduction; Pseudomonas; Pyruvic Acid | 2008 |
Probing the role of dynamics in hydride transfer catalyzed by lactate dehydrogenase.
Topics: Catalysis; Computer Simulation; Enzyme Activation; Kinetics; L-Lactate Dehydrogenase; Lactic Acid; Light; Models, Chemical; Models, Molecular; NAD; Pyruvic Acid | 2008 |
Crystal structures of the Mycobacterium tuberculosis secretory antigen alanine dehydrogenase (Rv2780) in apo and ternary complex forms captures "open" and "closed" enzyme conformations.
Topics: Alanine Dehydrogenase; Antigens, Bacterial; Apoproteins; Crystallography, X-Ray; Dimerization; Mycobacterium tuberculosis; NAD; Protein Structure, Quaternary; Protein Structure, Secondary; Protein Structure, Tertiary; Pyruvic Acid | 2008 |
Regulation of pyruvate dehydrogenase in the common killifish, Fundulus heteroclitus, during hypoxia exposure.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Cytosol; Energy Metabolism; Fundulidae; Hypoxia; Isoenzymes; Mitochondria; Muscle, Skeletal; NAD; Oxygen; Phylogeny; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Pyruvate Dehydrogenase Complex; Pyruvic Acid | 2008 |
Determination of pyruvic acid by using enzymic fluorescence capillary analysis.
Topics: Fluorometry; Humans; Hydrogen-Ion Concentration; L-Lactate Dehydrogenase; Microchemistry; NAD; Pyruvic Acid | 2008 |
A structural basis for substrate selectivity and stereoselectivity in octopine dehydrogenase from Pecten maximus.
Topics: Amino Acid Oxidoreductases; Amino Acid Sequence; Animals; Arginine; Binding Sites; Catalysis; Crystallography, X-Ray; Kinetics; Models, Molecular; Molecular Sequence Data; NAD; Pecten; Protein Binding; Protein Folding; Protein Structure, Tertiary; Pyruvic Acid; Sequence Alignment; Stereoisomerism; Substrate Specificity | 2008 |
Caloric restriction counteracts age-related changes in the activities of sorbitol metabolizing enzymes from mouse liver.
Topics: Age Factors; Aging; Aldehyde Reductase; Animals; Caloric Restriction; Fructose; Glucose; L-Iditol 2-Dehydrogenase; Lactic Acid; Liver; Malates; Male; Mice; Mice, Inbred C57BL; NAD; NADP; Oxidation-Reduction; Pyruvic Acid; Sorbitol | 2009 |
[Heterologous expression of H2O-forming NADH oxidase in Torulopsis glabrata significantly enhance the pyruvate productivity of the host].
Topics: Candida glabrata; DNA, Recombinant; Energy Metabolism; Fermentation; Gene Expression; Glycolysis; Lactococcus lactis; Multienzyme Complexes; NAD; NADH, NADPH Oxidoreductases; Oxidation-Reduction; Oxygen; Plasmids; Polymerase Chain Reaction; Pyruvic Acid; Water | 2008 |
Nanoparticle-supported multi-enzyme biocatalysis with in situ cofactor regeneration.
Topics: Animals; Biocatalysis; Cattle; Coenzymes; Enzymes, Immobilized; Glutamate Dehydrogenase; Glutamic Acid; Hydrogen-Ion Concentration; Ketoglutaric Acids; Kinetics; L-Lactate Dehydrogenase; Lactic Acid; Motion; NAD; Nanoparticles; Pyruvic Acid; Rabbits; Silicon Dioxide | 2009 |
Accelerated utilization of lactate under the effect of hypoxen after intensive exercise.
Topics: Animals; Energy Metabolism; Lactates; Male; Mice; Mitochondria, Liver; NAD; Oxidation-Reduction; Oxygen Consumption; Phenyl Ethers; Physical Conditioning, Animal; Pyruvic Acid; Rats; Rats, Wistar | 2008 |
Antimicrobial action of N-(n-dodecyl)diethanolamine on Escherichia coli: effects on enzymes and growing cultures.
Topics: Acetates; Anti-Bacterial Agents; Culture Media; Escherichia coli; Ethanolamines; Glyceraldehyde-3-Phosphate Dehydrogenases; NAD; Oxygen; Peptide Fragments; Pyruvic Acid | 2008 |
Glycerol: an unexpected major metabolite of energy metabolism by the human malaria parasite.
Topics: Alanine; Anaerobiosis; Animals; Energy Metabolism; Glucose; Glycerol; Humans; Lactic Acid; NAD; Oxidation-Reduction; Plasmodium falciparum; Pyruvic Acid; Spectrum Analysis | 2009 |
Production of panic-like symptoms by lactate is associated with increased neural firing and oxidation of brain redox in the rat hippocampus.
Topics: Action Potentials; Animals; Hippocampus; Injections; Lactates; NAD; Neurons; Oxidation-Reduction; Panic Disorder; Pyruvic Acid; Rats; Rats, Long-Evans; Sodium Lactate | 2009 |
Sample handling and chemical kinetics in an acoustically levitated drop microreactor.
Topics: Acoustics; Analytic Sample Preparation Methods; Animals; Biocatalysis; Cattle; Enzyme Assays; Kinetics; L-Lactate Dehydrogenase; Luminescent Measurements; Luminol; Microfluidic Analytical Techniques; NAD; Pyruvic Acid | 2009 |
Characterization of the L-lactate dehydrogenase from Aggregatibacter actinomycetemcomitans.
Topics: Bacterial Proteins; Biological Transport; Carbon; Gene Expression Regulation, Enzymologic; Glucose; Gram-Negative Bacteria; Kinetics; L-Lactate Dehydrogenase; Lactic Acid; Models, Biological; NAD; Protein Structure, Tertiary; Pyruvic Acid | 2009 |
Structure of D-lactate dehydrogenase from Aquifex aeolicus complexed with NAD(+) and lactic acid (or pyruvate).
Topics: Bacteria; Catalytic Domain; Cloning, Molecular; Crystallography, X-Ray; Genes, Bacterial; Lactate Dehydrogenases; Lactic Acid; Lactobacillus helveticus; Models, Molecular; NAD; Protein Conformation; Protein Structure, Quaternary; Protein Structure, Tertiary; Protein Subunits; Pyruvic Acid; Recombinant Proteins; Static Electricity | 2009 |
[Significantly increase of glycolytic flux and pyruvate productivity in Torulopsis glabrata by heterologous expression of NADH alternative oxidase].
Topics: Candida glabrata; Fungal Proteins; Gene Expression; Glucose; Glycolysis; Histoplasma; Mitochondrial Proteins; NAD; Oxidoreductases; Plant Proteins; Pyruvic Acid | 2009 |
Metabolic flux analysis of wild-type Escherichia coli and mutants deficient in pyruvate-dissimilating enzymes during the fermentative metabolism of glucuronate.
Topics: Acetyl Coenzyme A; Acetyltransferases; Escherichia coli; Escherichia coli Proteins; Fermentation; Glucuronates; NAD; Oxidation-Reduction; Pentose Phosphate Pathway; Pyruvic Acid | 2010 |
L-lactate generates hydrogen peroxide in purified rat liver mitochondria due to the putative L-lactate oxidase localized in the intermembrane space.
Topics: Animals; Hydrogen Peroxide; Hydrogen-Ion Concentration; Intracellular Membranes; Isoenzymes; L-Lactate Dehydrogenase; Lactic Acid; Male; Mitochondria; Mitochondria, Liver; Mixed Function Oxygenases; NAD; Oxidants; Pyruvic Acid; Rats; Rats, Wistar | 2010 |
Inhibition of glycolysis in the retina by oxidative stress: prevention by pyruvate.
Topics: Animals; Glycolysis; Mice; Mice, Inbred C57BL; NAD; Oxidative Stress; Pyruvic Acid; Reactive Oxygen Species; Retina | 2010 |
A new scheme to calculate isotope effects.
Topics: Algorithms; Biocatalysis; Catalytic Domain; Computer Simulation; Hydrogen Bonding; Isotopes; Kinetics; L-Lactate Dehydrogenase; Lactic Acid; Models, Chemical; Models, Molecular; NAD; Oxamic Acid; Pyruvic Acid | 2011 |
L-lactate metabolism can occur in normal and cancer prostate cells via the novel mitochondrial L-lactate dehydrogenase.
Topics: Carcinoma; Cells, Cultured; Dose-Response Relationship, Drug; Glucose; Humans; L-Lactate Dehydrogenase; Lactic Acid; Male; Mitochondria; Mitochondrial Swelling; NAD; Oxygen; Oxygen Consumption; Prostate; Prostatic Neoplasms; Pyruvic Acid | 2010 |
Characterization of lactate dehydrogenase enzyme in seminal plasma of Japanese quail (Coturnix coturnix japonica).
Topics: Animals; Coturnix; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Hydrogen-Ion Concentration; Isoenzymes; Kinetics; L-Lactate Dehydrogenase; Lactic Acid; Male; NAD; Pyruvic Acid; Semen; Spermatozoa; Urea | 2011 |
Constructing and testing the thermodynamic limits of synthetic NAD(P)H:H2 pathways.
Topics: Biosynthetic Pathways; Escherichia coli; Ferredoxins; Hydrogen; NAD; NADP; Pyruvic Acid; Thermodynamics | 2008 |
Synechococcus sp. strain PCC 7002 nifJ mutant lacking pyruvate:ferredoxin oxidoreductase.
Topics: Acetates; Darkness; Fermentation; Gene Knockout Techniques; Hydrogen; Lactic Acid; Light; NAD; Oxidation-Reduction; Pyruvate Synthase; Pyruvic Acid; Synechococcus | 2011 |
Discovery of N-hydroxyindole-based inhibitors of human lactate dehydrogenase isoform A (LDH-A) as starvation agents against cancer cells.
Topics: Antineoplastic Agents; Cell Cycle; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Glucose; Humans; Indoles; Isoenzymes; L-Lactate Dehydrogenase; Lactate Dehydrogenase 5; Lactic Acid; Models, Molecular; NAD; Pyruvic Acid; Structure-Activity Relationship; Substrate Specificity | 2011 |
Lactate dehydrogenase C and energy metabolism in mouse sperm.
Topics: Adenosine Triphosphate; Animals; Carbon Isotopes; Glucose; Glycolysis; Immunoprecipitation; Isoenzymes; L-Lactate Dehydrogenase; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Membrane Potential, Mitochondrial; Mice; Mice, Knockout; NAD; Oxamic Acid; Pyruvic Acid; Spermatozoa | 2011 |
Kinetic characterisation of recombinant Corynebacterium glutamicum NAD+-dependent LDH over-expressed in E. coli and its rescue of an lldD- phenotype in C. glutamicum: the issue of reversibility re-examined.
Topics: Bacterial Proteins; Cloning, Molecular; Corynebacterium glutamicum; Enzyme Activation; Escherichia coli; Fructosediphosphates; Gene Expression Regulation, Bacterial; Hydrogen-Ion Concentration; Kinetics; L-Lactate Dehydrogenase; Lactic Acid; Mutation; NAD; Open Reading Frames; Oxidation-Reduction; Pyruvic Acid; Recombinant Proteins | 2011 |
Conformational heterogeneity within the Michaelis complex of lactate dehydrogenase.
Topics: Catalytic Domain; Crystallography, X-Ray; L-Lactate Dehydrogenase; Models, Molecular; NAD; Protein Conformation; Pyruvic Acid; Spectroscopy, Fourier Transform Infrared; Vibration | 2011 |
Free [NADH]/[NAD(+)] regulates sirtuin expression.
Topics: Animals; Cells, Cultured; Drosophila melanogaster; Ethanol; Fibroblasts; Gene Expression Regulation; Lactic Acid; Male; Mice; NAD; NIH 3T3 Cells; Oxidation-Reduction; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Physical Conditioning, Animal; Pyruvic Acid; Rats; Rats, Wistar; RNA, Messenger; Sirtuins; Trans-Activators; Transcription Factors | 2011 |
Impact of high pyruvate concentration on kinetics of rabbit muscle lactate dehydrogenase.
Topics: Animals; Feedback, Physiological; Hydrogen-Ion Concentration; Kinetics; L-Lactate Dehydrogenase; Lactic Acid; Models, Chemical; Muscles; NAD; Pyruvic Acid; Rabbits; Software; Spectrophotometry | 2011 |
Reduced nicotinamide adenine dinucleotide fluorescence lifetime detected poly(adenosine-5'-diphosphate-ribose) polymerase-1-mediated cell death and therapeutic effect of pyruvate.
Topics: Adenosine Triphosphate; Cell Death; Cell Survival; Glucose; HeLa Cells; Humans; Membrane Potential, Mitochondrial; Methylnitronitrosoguanidine; Microscopy, Fluorescence; NAD; Oxygen Consumption; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Pyruvic Acid | 2011 |
Pyruvate incubation enhances glycogen stores and sustains neuronal function during subsequent glucose deprivation.
Topics: Adenosine Triphosphate; Animals; Energy Metabolism; Excitatory Postsynaptic Potentials; Glucose; Glycogen; Hippocampus; NAD; NADP; Neurons; Pyruvic Acid; Rats; Rats, Inbred F344; Synapses; Synaptic Transmission | 2012 |
Genetically encoded fluorescent sensors for intracellular NADH detection.
Topics: Bacterial Proteins; Cell Line; Cytosol; Glucose; Humans; Hydrogen Peroxide; Lactic Acid; Luminescent Proteins; Microscopy, Fluorescence; Mitochondria; NAD; Oxidation-Reduction; Pyruvic Acid | 2011 |
Determination of ammonium ion using a reagentless amperometric biosensor based on immobilized alanine dehydrogenase.
Topics: Alanine Dehydrogenase; Bacillus subtilis; Biosensing Techniques; Electrochemical Techniques; Electrodes; Enzymes, Immobilized; Hydrogen-Ion Concentration; Indicators and Reagents; Ions; Kinetics; Membranes, Artificial; NAD; Pyruvic Acid; Quaternary Ammonium Compounds; Reproducibility of Results; Solutions; Temperature; Water | 2011 |
Quercetin treatment changes fluxes in the primary metabolism and increases culture longevity and recombinant α₁-antitrypsin production in human AGE1.HN cells.
Topics: alpha 1-Antitrypsin; Biological Transport; Cell Line, Transformed; Cell Survival; Cells; Citric Acid Cycle; Glucose; Humans; NAD; Pyruvic Acid; Quercetin | 2012 |
Accumulation of pyruvate by changing the redox status in Escherichia coli.
Topics: Aerobiosis; Coenzymes; Escherichia coli; Formate Dehydrogenases; Glucose; Mycobacterium; NAD; Oxidation-Reduction; Pyruvic Acid; Recombinant Proteins | 2012 |
Influence of ethanol extract of Ginkgo biloba leaves on the isolated rat heart work and mitochondria functions.
Topics: Animals; Dose-Response Relationship, Drug; Ethanol; Fluorescence; Ginkgo biloba; Heart Rate; Hydrogen Peroxide; Malates; Male; Mitochondria, Heart; Myocardial Contraction; Myocardial Reperfusion Injury; NAD; Oxidation-Reduction; Plant Extracts; Plant Leaves; Pyruvic Acid; Rats; Rats, Wistar; Time Factors | 2012 |
Ca²⁺ signals of astrocytes are modulated by the NAD⁺/NADH redox state.
Topics: Animals; Astrocytes; Benzazepines; Calcium; Calcium Signaling; Cells, Cultured; Cerebral Cortex; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Glucose; Isoquinolines; Lactic Acid; Mice; Mice, Inbred C57BL; NAD; Oxidation-Reduction; Protein Kinase Inhibitors; Pyruvic Acid; Sulfonamides | 2012 |
Amino acid substitutions at glutamate-354 in dihydrolipoamide dehydrogenase of Escherichia coli lower the sensitivity of pyruvate dehydrogenase to NADH.
Topics: Amino Acid Substitution; Dihydrolipoamide Dehydrogenase; Escherichia coli; Escherichia coli Proteins; Ethanol; Fermentation; Glutamic Acid; Models, Molecular; Mutagenesis, Site-Directed; NAD; Pyruvate Dehydrogenase Complex; Pyruvic Acid | 2012 |
Effects of aripiprazole and clozapine on the treatment of glycolytic carbon in PC12 cells.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Antipsychotic Agents; Apoptosis; Aripiprazole; Carbon; Cell Survival; Clozapine; Dihydrolipoamide Dehydrogenase; Dose-Response Relationship, Drug; Electron Transport Complex IV; Extracellular Fluid; Gene Expression Regulation, Enzymologic; Glucose; Glycolysis; Hypoxanthine Phosphoribosyltransferase; Isocitrate Dehydrogenase; Ketone Oxidoreductases; Lactic Acid; Membrane Potential, Mitochondrial; NAD; Oxidoreductases; PC12 Cells; Piperazines; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Pyruvic Acid; Quinolones; Rats; RNA, Messenger; Time Factors | 2012 |
Control of D-octopine formation in scallop adductor muscle as revealed through thermodynamic studies of octopine dehydrogenase.
Topics: Adenosine Triphosphate; Amino Acid Oxidoreductases; Animals; Arginine; Binding Sites; Calorimetry; Kinetics; Models, Chemical; Movement; Muscles; NAD; Pectinidae; Pyruvic Acid; Substrate Specificity; Swimming; Thermodynamics | 2012 |
In situ regeneration of NADH via lipoamide dehydrogenase-catalyzed electron transfer reaction evidenced by spectroelectrochemistry.
Topics: Dihydrolipoamide Dehydrogenase; Electrochemical Techniques; Electrodes; Electron Transport; Lactates; NAD; Pyruvic Acid; Spectrophotometry, Ultraviolet | 2012 |
Peroxisomal alanine: glyoxylate aminotransferase AGT1 is indispensable for appressorium function of the rice blast pathogen, Magnaporthe oryzae.
Topics: Gene Expression Regulation, Fungal; Glyoxylates; Hordeum; Magnaporthe; NAD; Oryza; Oxidation-Reduction; Peroxisomes; Plant Diseases; Protein Transport; Pyruvic Acid; Sequence Deletion; Surface Properties; Transaminases | 2012 |
Coenzyme regeneration in hexanol oxidation catalyzed by alcohol dehydrogenase.
Topics: Acetaldehyde; Alcohol Dehydrogenase; Animals; Biocatalysis; Hexanols; Kinetics; L-Lactate Dehydrogenase; Models, Chemical; NAD; Oxidation-Reduction; Permeability; Pyruvic Acid; Rabbits; Reproducibility of Results; Saccharomyces cerevisiae | 2012 |
Mitochondrial inhibitor models of Huntington's disease and Parkinson's disease induce zinc accumulation and are attenuated by inhibition of zinc neurotoxicity in vitro or in vivo.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Carrier Proteins; Cation Transport Proteins; Cell Death; Cells, Cultured; Cerebral Cortex; Dihydroxyacetone Phosphate; Disease Models, Animal; Drug Interactions; Embryo, Mammalian; Fructose-Bisphosphatase; Humans; Huntington Disease; Male; Matrix Metalloproteinase 16; Membrane Proteins; Membrane Transport Proteins; Mental Disorders; Mice; Mice, Inbred C57BL; Mice, Neurologic Mutants; Mice, Transgenic; NAD; Neurons; Niacinamide; Nitro Compounds; Oxidopamine; Parkinson Disease; Propionates; Pyruvic Acid; Rats; Rats, Long-Evans; Tyrosine 3-Monooxygenase; Zinc | 2013 |
Role of hyperglycemia-mediated erythrocyte redox state alteration in the development of diabetic retinopathy.
Topics: Blood Glucose; Blood Pressure; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Erythrocyte Membrane; Erythrocytes; Female; Fluorescein Angiography; Glucose Tolerance Test; Glutathione; Glycated Hemoglobin; Humans; Hyperglycemia; Lactic Acid; Male; Middle Aged; NAD; NADP; Oxidation-Reduction; Pyruvic Acid | 2013 |
Presence of bound substrate in lactate dehydrogenase from carp liver.
Topics: Animals; Carps; Chromatography, Gel; Enzyme Stability; L-Lactate Dehydrogenase; Lactic Acid; Liver; Mass Spectrometry; NAD; Pyruvic Acid; UDPglucose 4-Epimerase | 2012 |
Glucose is a pH-dependent motor for sperm beat frequency during early activation.
Topics: Adenosine Triphosphate; Adenylyl Cyclases; Animals; Carbonic Anhydrases; Cyclic AMP-Dependent Protein Kinases; Deoxyglucose; Energy Metabolism; Glucose; Hydrogen-Ion Concentration; Lactic Acid; Male; Methylamines; Mice; Mitochondria; NAD; NADP; Propionates; Pyruvic Acid; Sperm Motility; Spermatozoa; Succinic Acid | 2012 |
Metabolic master regulators: sharing information among multiple systems.
Topics: Adipose Tissue; Diabetes Mellitus, Type 2; Female; Homeostasis; Humans; Insulin Resistance; Lactic Acid; Liver; Metabolome; Mitochondria; Models, Biological; Muscles; NAD; NADP; Obesity; Oxidation-Reduction; Pyruvic Acid; Signal Transduction | 2012 |
Aralar mRNA and protein levels in neurons and astrocytes freshly isolated from young and adult mouse brain and in maturing cultured astrocytes.
Topics: Aging; Animals; Aspartic Acid; Astrocytes; Brain; Cell Separation; Cells, Cultured; Cellular Senescence; Cytoplasm; Energy Metabolism; Female; Glutamic Acid; Lactic Acid; Male; Mice; Mice, Transgenic; Mitochondria; Mitochondrial Membrane Transport Proteins; NAD; Nerve Tissue Proteins; Neurons; Oxidation-Reduction; Primary Cell Culture; Pyruvic Acid; Real-Time Polymerase Chain Reaction; RNA, Messenger | 2012 |
Dietary zinc reduction, pyruvate supplementation, or zinc transporter 5 knockout attenuates β-cell death in nonobese diabetic mice, islets, and insulinoma cells.
Topics: Animals; Benzamides; Calcium Channel Blockers; Carrier Proteins; Cell Line, Tumor; Diabetes Mellitus, Experimental; Dietary Supplements; Female; Insulinoma; Islets of Langerhans; Male; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Mice, Knockout; NAD; Naphthols; Pancreatic Neoplasms; Pyruvic Acid; Reactive Oxygen Species; Streptozocin; Zinc | 2012 |
A rapid method for direct detection of metabolic conversion and magnetization exchange with application to hyperpolarized substrates.
Topics: Adenocarcinoma; Algorithms; Animals; Electromagnetic Fields; Humans; Kinetics; L-Lactate Dehydrogenase; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Metabolism; Mice; Mice, Transgenic; NAD; Prostatic Neoplasms; Pyruvic Acid; Radio Waves; Tissue Distribution | 2012 |
Effect of ouabain on metabolic oxidative state in living cardiomyocytes evaluated by time-resolved spectroscopy of endogenous NAD(P)H fluorescence.
Topics: Animals; Cardiotonic Agents; Female; Lactic Acid; Mitochondria; Myocytes, Cardiac; NAD; NADP; Ouabain; Oxidation-Reduction; Pyruvic Acid; Rats; Rats, Sprague-Dawley; Spectrometry, Fluorescence | 2012 |
NAD(+) maintenance attenuates light induced photoreceptor degeneration.
Topics: Animals; Antioxidants; Cell Death; Cells, Cultured; Circadian Rhythm; Cytoprotection; Disease Models, Animal; Feeding Behavior; Hydrogen Peroxide; Light; Mice; Mice, Inbred C57BL; Mice, Transgenic; NAD; Niacinamide; Nicotinamide-Nucleotide Adenylyltransferase; Oxidants; Oxidative Stress; Photoreceptor Cells, Vertebrate; Pyruvic Acid; Rats; Rats, Sprague-Dawley; Retinal Degeneration; Time Factors; Zinc | 2013 |
Lactate oxidation in human skeletal muscle mitochondria.
Topics: Cell Respiration; Female; Humans; L-Lactate Dehydrogenase; Lactic Acid; Male; Mitochondria, Muscle; Muscle Fibers, Skeletal; Muscle, Skeletal; NAD; Oxidation-Reduction; Pyruvic Acid | 2013 |
Nanoparticle-tethered NAD(+) with in situ cofactor regeneration.
Topics: Alcohol Oxidoreductases; Coenzymes; Formate Dehydrogenases; Formates; Lactic Acid; NAD; Nanoparticles; Propylamines; Pyruvic Acid; Silanes; Silicon Dioxide | 2013 |
Impact of peripheral ketolytic deficiency on hepatic ketogenesis and gluconeogenesis during the transition to birth.
Topics: 3-Hydroxybutyric Acid; Animals; Animals, Newborn; Citric Acid Cycle; Coenzyme A-Transferases; Female; Gluconeogenesis; Glucose; Hypoglycemia; Ketone Bodies; Liver; Mice; Mice, Knockout; NAD; Oxidation-Reduction; Parturition; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Pyruvic Acid; Trans-Activators; Transcription Factors | 2013 |
Isolation of a high malic and low acetic acid-producing sake yeast Saccharomyces cerevisiae strain screened from respiratory inhibitor 2,4-dinitrophenol (DNP)-resistant strains.
Topics: 2,4-Dinitrophenol; Acetic Acid; Cytosol; Drug Resistance, Fungal; Ethanol; Malates; Mitochondria; Mutagenesis; NAD; Pyruvic Acid; Saccharomyces cerevisiae | 2014 |
Label-free high-throughput assays to screen and characterize novel lactate dehydrogenase inhibitors.
Topics: Enzyme Assays; Enzyme Inhibitors; High-Throughput Screening Assays; Humans; L-Lactate Dehydrogenase; Lactic Acid; Mass Spectrometry; NAD; Neoplasms; Pyruvic Acid; Spectrometry, Fluorescence | 2013 |
A possible role for the chloroplast pyruvate dehydrogenase complex in plant glycolate and glyoxylate metabolism.
Topics: Carbon Dioxide; Cell Respiration; Chloroplasts; Decarboxylation; Glycolates; Glyoxylates; Heat-Shock Proteins; Kinetics; NAD; Nicotiana; Photosynthesis; Pyruvate Dehydrogenase Complex; Pyruvic Acid; Ribulose-Bisphosphate Carboxylase | 2013 |
Directed evolution of thermotolerant malic enzyme for improved malate production.
Topics: Biocatalysis; Directed Molecular Evolution; Enzyme Assays; Gene Library; Kinetics; Malate Dehydrogenase; Malates; NAD; NADP; Oxidation-Reduction; Point Mutation; Protein Engineering; Pyruvic Acid; Substrate Specificity; Thermococcus | 2014 |
Live-cell imaging of cytosolic NADH-NAD+ redox state using a genetically encoded fluorescent biosensor.
Topics: Animals; Biosensing Techniques; Calibration; Cell Line, Tumor; Cell Survival; Cytosol; Lactic Acid; Luminescent Proteins; Mice; Molecular Imaging; NAD; Oxidation-Reduction; Protein Engineering; Pyruvic Acid; Single-Cell Analysis | 2014 |
Non-invasive in-cell determination of free cytosolic [NAD+]/[NADH] ratios using hyperpolarized glucose show large variations in metabolic phenotypes.
Topics: Breast Neoplasms; Cell Line, Tumor; Female; Glucose; Glycolysis; Humans; Lactic Acid; Male; NAD; Prostatic Neoplasms; Pyruvic Acid | 2014 |
Isoflurane modulates cardiac mitochondrial bioenergetics by selectively attenuating respiratory complexes.
Topics: Animals; Antimycin A; Electron Transport; Electron Transport Complex I; Electron Transport Complex II; Electron Transport Complex III; Energy Metabolism; Isoflurane; Malates; Membrane Potential, Mitochondrial; Mitochondria, Heart; Models, Biological; NAD; Oxidation-Reduction; Oxygen Consumption; Pyruvic Acid; Rats; Rats, Wistar; Rotenone; Spectrometry, Fluorescence; Succinic Acid; Uncoupling Agents | 2014 |
Energy landscape of the Michaelis complex of lactate dehydrogenase: relationship to catalytic mechanism.
Topics: Animals; Catalysis; Catalytic Domain; Energy Metabolism; Hydro-Lyases; NAD; Pyruvic Acid; Spectroscopy, Fourier Transform Infrared; Stochastic Processes; Swine | 2014 |
Phenazine redox cycling enhances anaerobic survival in Pseudomonas aeruginosa by facilitating generation of ATP and a proton-motive force.
Topics: Acetate Kinase; Acetic Acid; Adenosine Triphosphate; Anaerobiosis; Energy Metabolism; Fermentation; Glucose; Microbial Viability; NAD; Oxidation-Reduction; Phenazines; Proton-Motive Force; Pseudomonas aeruginosa; Pyruvic Acid | 2014 |
Metabolic engineering of Candida glabrata for diacetyl production.
Topics: Acetoin Dehydrogenase; Acetolactate Synthase; Alcohol Oxidoreductases; Candida glabrata; Carbon Cycle; Culture Media; Decarboxylation; Diacetyl; Fermentation; Gene Deletion; Iron; Lactates; Metabolic Engineering; Metabolic Networks and Pathways; NAD; Niacin; Pyruvic Acid; Thiamine | 2014 |
Purification and characterization of a urea sensitive lactate dehydrogenase from the liver of the African clawed frog, Xenopus laevis.
Topics: Animals; Dehydration; L-Lactate Dehydrogenase; Lactic Acid; Liver; Male; NAD; Protein Processing, Post-Translational; Pyruvic Acid; Urea; Xenopus laevis | 2014 |
Macromolecular crowding effect upon in vitro enzyme kinetics: mixed activation-diffusion control of the oxidation of NADH by pyruvate catalyzed by lactate dehydrogenase.
Topics: Animals; Biocatalysis; Diffusion; Kinetics; L-Lactate Dehydrogenase; Macromolecular Substances; Muscles; NAD; Oxidation-Reduction; Pyruvic Acid; Rabbits | 2014 |
Paper microfluidic-based enzyme catalyzed double microreactor.
Topics: Animals; Bioreactors; Cattle; Dihydrolipoamide Dehydrogenase; Enzymes, Immobilized; Equipment Design; Fluorescence; Fluorescent Dyes; L-Lactate Dehydrogenase; Lactic Acid; Microfluidic Analytical Techniques; NAD; Oxazines; Paper; Potassium Chloride; Pyruvic Acid; Serum Albumin, Bovine; Xanthenes | 2014 |
Enzyme-based logic gates switchable between OR, NXOR and NAND Boolean operations realized in a flow system.
Topics: Algorithms; Biocatalysis; Enzymes; Glucose; Glucose 1-Dehydrogenase; Glucose-6-Phosphate; Glucosephosphate Dehydrogenase; L-Lactate Dehydrogenase; Malate Dehydrogenase; NAD; Oxaloacetic Acid; Oxidation-Reduction; Pyruvic Acid | 2014 |
Parental environmental exposure leads to glycometabolic disturbances that affect fertilization of eggs in the silkworm Bombyx mori: the parental transcript legacy.
Topics: Animals; Bombyx; Citric Acid Cycle; Environmental Exposure; Fertilization; Germ Cells; Glycolysis; Lactic Acid; Light; NAD; Pyruvic Acid; Real-Time Polymerase Chain Reaction | 2015 |
Hollow microgel based ultrathin thermoresponsive membranes for separation, synthesis, and catalytic applications.
Topics: Catalysis; Coloring Agents; Cross-Linking Reagents; Enzymes, Immobilized; Gels; Gold; L-Lactate Dehydrogenase; Lactic Acid; Membranes, Artificial; Metal Nanoparticles; Microscopy, Electron, Scanning; Muramidase; NAD; Pyruvic Acid; Temperature; Water | 2014 |
Metabolic regulation of phytoplasma malic enzyme and phosphotransacetylase supports the use of malate as an energy source in these plant pathogens.
Topics: Acetyl Coenzyme A; Carbon Dioxide; Energy Metabolism; Gene Expression Regulation, Bacterial; Gene Expression Regulation, Enzymologic; Malate Dehydrogenase; Malates; NAD; NADP; Phosphate Acetyltransferase; Phytoplasma; Pyruvic Acid | 2014 |
Changes in pyruvate metabolism detected by magnetic resonance imaging are linked to DNA damage and serve as a sensor of temozolomide response in glioblastoma cells.
Topics: Apoptosis; Biomarkers, Tumor; Carrier Proteins; Cell Line, Tumor; Checkpoint Kinase 1; Dacarbazine; DNA Damage; DNA Repair; Gene Expression; Glioblastoma; Humans; L-Lactate Dehydrogenase; Magnetic Resonance Imaging; Membrane Proteins; Methyltransferases; NAD; Protein Kinases; Pyruvic Acid; Temozolomide; Thyroid Hormone-Binding Proteins; Thyroid Hormones | 2014 |
The FlxABCD-HdrABC proteins correspond to a novel NADH dehydrogenase/heterodisulfide reductase widespread in anaerobic bacteria and involved in ethanol metabolism in Desulfovibrio vulgaris Hildenborough.
Topics: Desulfovibrio vulgaris; Electrons; Energy Metabolism; Ethanol; Ferredoxins; FMN Reductase; NAD; NADH Dehydrogenase; Oxidation-Reduction; Oxidoreductases; Pyruvic Acid; Sulfates | 2015 |
Mitochondrial physiology in the major arbovirus vector Aedes aegypti: substrate preferences and sexual differences define respiratory capacity and superoxide production.
Topics: Aedes; Animals; Arboviruses; Body Size; Cytochromes c; Dengue; Electron Transport Complex I; Female; Glycerolphosphate Dehydrogenase; Glycerophosphates; Humans; Insect Proteins; Insect Vectors; Male; Mitochondria, Muscle; NAD; Oxidation-Reduction; Oxygen Consumption; Proline; Pyruvic Acid; Sex Characteristics; Superoxides | 2015 |
Glucose consumption rate critically depends on redox state in Corynebacterium glutamicum under oxygen deprivation.
Topics: Corynebacterium glutamicum; Gene Deletion; Gene Expression; Glucose; L-Lactate Dehydrogenase; Malate Dehydrogenase; NAD; NADH Dehydrogenase; Oxidation-Reduction; Oxygen; Phosphoenolpyruvate Carboxylase; Pyruvic Acid; Sodium Bicarbonate | 2015 |
Free energy surface of the Michaelis complex of lactate dehydrogenase: a network analysis of microsecond simulations.
Topics: Biocatalysis; Kinetics; L-Lactate Dehydrogenase; Molecular Dynamics Simulation; NAD; Protein Conformation; Pyruvic Acid; Thermodynamics; Time Factors | 2015 |
The brain metabolic activity after resuscitation with liposome-encapsulated hemoglobin in a rat model of hypovolemic shock.
Topics: Adenosine Triphosphate; Animals; Blood Substitutes; Brain; Citrate (si)-Synthase; Disease Models, Animal; Glucose-6-Phosphate; Hemoglobins; Hexokinase; Liposomes; Male; NAD; Nerve Growth Factor; Pyruvic Acid; Rats; Rats, Sprague-Dawley; Resuscitation; Shock | 2015 |
Functional response of the isolated, perfused normoxic heart to pyruvate dehydrogenase activation by dichloroacetate and pyruvate.
Topics: Animals; Calcium; Dichloroacetic Acid; Glucose; Heart; Isolated Heart Preparation; Myocardial Contraction; Myocardium; NAD; Pyruvate Dehydrogenase Complex; Pyruvic Acid; Rats; Rats, Sprague-Dawley; Ventricular Function | 2016 |
Hemorrhagic shock-induced cerebral bioenergetic imbalance is corrected by pharmacologic treatment with EF24 in a rat model.
Topics: Adenosine Triphosphate; Animals; Benzylidene Compounds; Brain; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Energy Metabolism; Male; Mitochondria; NAD; Nerve Growth Factor; Neuroprotective Agents; Phosphocreatine; Piperidones; Pyruvic Acid; Rats, Sprague-Dawley; Shock, Hemorrhagic | 2015 |
Identification of active elementary flux modes in mitochondria using selectively permeabilized CHO cells.
Topics: Adenosine Diphosphate; Amino Acids; Animals; Carbon Dioxide; CHO Cells; Citrates; Citric Acid Cycle; Cricetinae; Cricetulus; Isocitrate Dehydrogenase; Ketoglutarate Dehydrogenase Complex; Metabolic Networks and Pathways; Mitochondria; NAD; Oxidative Phosphorylation; Pyruvic Acid | 2015 |
Impaired energy metabolism of the taurine‑deficient heart.
Topics: Acetyl Coenzyme A; Adenosine Triphosphate; Animals; Carnitine O-Palmitoyltransferase; Citric Acid Cycle; Electron Transport; Energy Metabolism; Glucose; Glycolysis; Heart; Magnesium; Male; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; NAD; Oxidation-Reduction; Palmitates; Pyruvic Acid; Rats; Rats, Wistar; Taurine | 2016 |
Modeling non-linear kinetics of hyperpolarized [1-(13)C] pyruvate in the crystalloid-perfused rat heart.
Topics: Animals; Carbon Isotopes; Crystalloid Solutions; Fluorescence; Glucose; Heart; Isotonic Solutions; Kinetics; Magnetic Resonance Spectroscopy; Male; NAD; Nonlinear Dynamics; Perfusion; Pyruvic Acid; Rats, Wistar | 2016 |
Oxaloacetate enhances neuronal cell bioenergetic fluxes and infrastructure.
Topics: Adenosine Triphosphate; Cell Line; Cell Line, Tumor; Cytosol; Energy Metabolism; Glucose; Glycolysis; Humans; Malate Dehydrogenase; Malates; Mitochondria; NAD; Neuroblastoma; Neurons; Oxaloacetic Acid; Oxygen Consumption; Pyruvic Acid; RNA, Messenger | 2016 |
Characterization of an Arxula adeninivorans alcohol dehydrogenase involved in the metabolism of ethanol and 1-butanol.
Topics: 1-Butanol; Alcohol Dehydrogenase; Amino Acid Sequence; Carbon; Coenzymes; Cytoplasm; Ethanol; Gene Expression Profiling; Molecular Sequence Data; NAD; Pyruvic Acid; Saccharomycetales; Sequence Homology, Amino Acid; Xylose | 2016 |
Exogenous pyruvate facilitates cancer cell adaptation to hypoxia by serving as an oxygen surrogate.
Topics: Acetyl Coenzyme A; Adaptation, Physiological; Adenosine Triphosphate; Cell Proliferation; Electron Transport; Glycolysis; Humans; NAD; Neoplasms; Oxaloacetic Acid; Oxygen; Pyruvic Acid; TOR Serine-Threonine Kinases | 2016 |
The Development of Leucine Dehydrogenase and Formate Dehydrogenase Bifunctional Enzyme Cascade Improves the Biosynthsis of L-tert-Leucine.
Topics: Amination; Biosynthetic Pathways; Electrophoresis, Polyacrylamide Gel; Enzyme Stability; Formate Dehydrogenases; Hydrogen-Ion Concentration; Kinetics; Leucine; Leucine Dehydrogenase; Multienzyme Complexes; NAD; Oxidation-Reduction; Pyruvic Acid; Recombinant Proteins; Temperature | 2016 |
Metabolic engineering of Escherichia coli W3110 to produce L-malate.
Topics: Bacterial Proteins; Bioreactors; Escherichia coli; Gene Deletion; Malate Dehydrogenase; Malates; Metabolic Engineering; NAD; Pyruvic Acid; Recombinant Proteins | 2017 |
Environment Dictates Dependence on Mitochondrial Complex I for NAD+ and Aspartate Production and Determines Cancer Cell Sensitivity to Metformin.
Topics: Animals; Aspartic Acid; Cell Line, Tumor; Cell Proliferation; Electron Transport Complex I; Homeostasis; Humans; Metformin; Mice, Nude; Mitochondria; NAD; Neoplasms; Pyruvic Acid; Tumor Microenvironment | 2016 |
Pyruvate dehydrogenase complex regulator (PdhR) gene deletion boosts glucose metabolism in Escherichia coli under oxygen-limited culture conditions.
Topics: Acetic Acid; Cell Respiration; Cytochrome b Group; Cytochromes; Escherichia coli; Escherichia coli Proteins; Fermentation; Gene Deletion; Genes, Regulator; Glucose; NAD; NADH Dehydrogenase; Oxidation-Reduction; Oxygen; Pyruvate Dehydrogenase Complex; Pyruvic Acid; Repressor Proteins | 2017 |
Specific Arabidopsis thaliana malic enzyme isoforms can provide anaplerotic pyruvate carboxylation function in Saccharomyces cerevisiae.
Topics: Arabidopsis; Arabidopsis Proteins; Carbon Dioxide; Cloning, Molecular; Gene Expression; Genetic Complementation Test; Genetic Engineering; Glucose; Isoenzymes; Malate Dehydrogenase (NADP+); Malates; NAD; NADP; Plant Leaves; Pyruvic Acid; Recombinant Proteins; Saccharomyces cerevisiae; Transformation, Genetic; Transgenes | 2017 |
Mitochondria play an important role in the cell proliferation suppressing activity of berberine.
Topics: Berberine; Butyrates; Cell Line, Tumor; Cell Proliferation; Citric Acid Cycle; DNA, Mitochondrial; Dose-Response Relationship, Drug; Gene Dosage; Humans; Mitochondria; NAD; Pyruvic Acid | 2017 |
Nicotine Adenine Dinucleotides: The Redox Currency of the Cell.
Topics: Humans; Lactic Acid; NAD; Oxidation-Reduction; Pyruvic Acid | 2018 |
Pyruvate Protects against Cellular Senescence through the Control of Mitochondrial and Lysosomal Function in Dermal Fibroblasts.
Topics: Cells, Cultured; Cellular Senescence; Dermis; Epidermis; Fibroblasts; Histones; Humans; Ligases; Lysosomes; Mitochondria; Mitophagy; NAD; PPAR gamma; Pyruvic Acid | 2018 |
Altering the sensitivity of Escherichia coli pyruvate dehydrogenase complex to NADH inhibition by structure-guided design.
Topics: Amino Acid Sequence; Anaerobiosis; Escherichia coli; Escherichia coli Proteins; Models, Molecular; Mutagenesis, Site-Directed; Mutation; NAD; Oxidation-Reduction; Protein Conformation; Pyruvate Dehydrogenase Complex; Pyruvic Acid; Sequence Homology | 2018 |
Rescue from galactose-induced death of Leigh Syndrome patient cells by pyruvate and NAD
Topics: Adenosine Triphosphate; Aspartic Acid; Cell Death; Culture Media; Electron Transport Complex I; Fibroblasts; Galactose; Gene Expression; Glycolysis; Humans; Ketoglutaric Acids; Leigh Disease; Malates; Mitochondria; Mitochondrial Diseases; Mutation; NAD; NADH Dehydrogenase; Oxaloacetic Acid; Primary Cell Culture; Pyruvic Acid; Skin | 2018 |
A novel bioreactor for combined magnetic resonance spectroscopy and optical imaging of metabolism in 3D cell cultures.
Topics: Animals; Bioreactors; Cell Line, Tumor; Cell Survival; Collagen; Contrast Media; Diffusion; Disease Progression; Equipment Design; Female; Gels; Glucose; Lactic Acid; Magnetic Resonance Spectroscopy; Mammary Neoplasms, Animal; Mammary Neoplasms, Experimental; Mice; NAD; Optical Imaging; Printing, Three-Dimensional; Pyruvic Acid; Temperature | 2019 |
Effect of infectious bursal disease virus infection on energy metabolism in embryonic chicken livers.
Topics: Adenosine Triphosphate; Animals; Chick Embryo; Chorioallantoic Membrane; Cytosol; Electron Transport Complex I; Energy Metabolism; Glycolysis; Infectious bursal disease virus; L-Lactate Dehydrogenase; Lactic Acid; Liver; Luminescent Measurements; Mitochondria; NAD; Phosphopyruvate Hydratase; Proteins; Pyruvic Acid; Random Allocation; RNA, Viral; Specific Pathogen-Free Organisms; Virulence; Virus Replication | 2019 |
A Semi-High-Throughput Adaptation of the NADH-Coupled ATPase Assay for Screening Small Molecule Inhibitors.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Enzyme Inhibitors; High-Throughput Screening Assays; Hydrolysis; Lactic Acid; Myosin Type II; NAD; Oxidation-Reduction; Pyruvic Acid | 2019 |
Exogenous pyruvate represses histone gene expression and inhibits cancer cell proliferation via the NAMPT-NAD+-SIRT1 pathway.
Topics: Animals; Cell Proliferation; Cells, Cultured; Cytokines; Down-Regulation; Gene Expression Regulation, Neoplastic; HeLa Cells; Hep G2 Cells; Histones; Humans; MCF-7 Cells; Mice; Mice, Inbred BALB C; Mice, Nude; NAD; Neoplasms; Nicotinamide Phosphoribosyltransferase; Pyruvic Acid; Sirtuin 1; Xenograft Model Antitumor Assays | 2019 |
From in vitro to in silico: Modeling and recombinant production of DT-Diaphorase enzyme.
Topics: Biosensing Techniques; Biotechnology; Escherichia coli; Glucose; NAD; NAD(P)H Dehydrogenase (Quinone); Phenylalanine; Pyruvic Acid; Recombinant Proteins | 2020 |
Crowding-Induced Uncompetitive Inhibition of Lactate Dehydrogenase: Role of Entropic Pushing.
Topics: Biocatalysis; Catalytic Domain; Diffusion; Entropy; Ficoll; Humans; Kinetics; L-Lactate Dehydrogenase; Molecular Dynamics Simulation; NAD; Polyethylene Glycols; Pyruvic Acid | 2020 |
An engineered enzyme that targets circulating lactate to alleviate intracellular NADH:NAD
Topics: Bacteria; Bacterial Proteins; Catalase; HeLa Cells; Humans; K562 Cells; Lactic Acid; Mixed Function Oxygenases; NAD; Protein Engineering; Pyruvic Acid; Recombinant Fusion Proteins | 2020 |
The heterocyclic compound Tempol inhibits the growth of cancer cells by interfering with glutamine metabolism.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Cyclic N-Oxides; Female; Glutamine; Glycolysis; Heterocyclic Compounds; Humans; Isocitrate Dehydrogenase; Isocitrates; Ketoglutaric Acids; Mice, Inbred BALB C; Mice, Nude; Mitochondria; Molecular Docking Simulation; NAD; Neoplasms; Oxidative Phosphorylation; Pyruvic Acid; Reactive Oxygen Species; Serine; Spin Labels; Xenograft Model Antitumor Assays | 2020 |
Protein cysteine S-nitrosylation provides reducing power by enhancing lactate dehydrogenase activity in Trichomonas vaginalis under iron deficiency.
Topics: Cysteine; Glycolysis; Iron; L-Lactate Dehydrogenase; NAD; Nitric Oxide; Oxidation-Reduction; Protein Modification, Translational; Protozoan Proteins; Pyruvic Acid; Trichomonas vaginalis | 2020 |
The mitochondrial pyruvate carrier (MPC) complex mediates one of three pyruvate-supplying pathways that sustain Arabidopsis respiratory metabolism.
Topics: Acrylates; Alanine; Alanine Transaminase; Anion Transport Proteins; Arabidopsis; Arabidopsis Proteins; Biological Transport; Cycloserine; Enzyme Inhibitors; Malate Dehydrogenase; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Proteins; Monocarboxylic Acid Transporters; Multiprotein Complexes; NAD; Plants, Genetically Modified; Pyruvic Acid | 2021 |
The level of secondary messengers and the redox state of NAD
Topics: Adult; Calcium; Cyclic AMP; Humans; Infertility, Male; Male; NAD; Oxidation-Reduction; Pyridines; Pyruvic Acid; Semen Analysis; Sperm Count; Sperm Motility; Spermatozoa; Young Adult | 2021 |
A hydride transfer complex reprograms NAD metabolism and bypasses senescence.
Topics: Aging; Animals; Cell Line, Tumor; Cellular Senescence; Cytosol; Glucose; Humans; Hydrogen; Malate Dehydrogenase; Male; Mice; Mice, Inbred NOD; Mice, Transgenic; NAD; Oxidation-Reduction; Pyruvate Carboxylase; Pyruvic Acid | 2021 |
Lactate and Pyruvate Activate Autophagy and Mitophagy that Protect Cells in Toxic Model of Parkinson's Disease.
Topics: Animals; Astrocytes; Autophagy; Cell Line, Tumor; Cell Survival; Humans; Lactic Acid; Membrane Potential, Mitochondrial; Mitochondria; Mitophagy; NAD; Neurons; Parkinson Disease; Pyruvic Acid; Rats | 2022 |
Rewired Cellular Metabolic Profiles in Response to Metformin under Different Oxygen and Nutrient Conditions.
Topics: Cell Line, Tumor; Cell Proliferation; Culture Media; Glucose; Glutamine; HeLa Cells; Humans; Lactic Acid; Metabolomics; Metformin; NAD; Oxygen; Pyruvic Acid; Tumor Hypoxia | 2022 |
The electron-bifurcating FeFe-hydrogenase Hnd is involved in ethanol metabolism in Desulfovibrio fructosovorans grown on pyruvate.
Topics: Desulfovibrio; Electrons; Ethanol; Ferredoxins; Hydrogen; Hydrogenase; NAD; Oxidation-Reduction; Pyruvic Acid | 2022 |
Quantitative analysis of the interaction of ethanol metabolism with gluconeogenesis and fatty acid oxidation in the perfused liver of fasted rats.
Topics: Animals; Ethanol; Fatty Acids; Gluconeogenesis; Lactic Acid; Lipid Metabolism; Liver; NAD; Oxidation-Reduction; Pyruvic Acid; Rats | 2022 |
Deuterium Metabolic Imaging Reports on TERT Expression and Early Response to Therapy in Cancer.
Topics: Animals; Deuterium; Glioblastoma; Lactic Acid; Mice; NAD; Pyruvic Acid; Telomerase | 2022 |
Metabolic evidence for distinct pyruvate pools inside plant mitochondria.
Topics: Citrates; Cytosol; Mitochondria; NAD; Plants; Pyruvic Acid | 2022 |
Pyruvate and uridine rescue the metabolic profile of OXPHOS dysfunction.
Topics: Animals; Metabolome; Mitochondrial Diseases; NAD; Oxidative Phosphorylation; Pyruvic Acid; Rotenone; Uridine; Zebrafish | 2022 |
Metabolic requirement for GOT2 in pancreatic cancer depends on environmental context.
Topics: Animals; Aspartate Aminotransferase, Mitochondrial; Carcinoma, Pancreatic Ductal; Fatty Acid-Binding Proteins; Humans; Mice; NAD; Pancreatic Neoplasms; Proto-Oncogene Proteins p21(ras); Pyruvic Acid; Tumor Microenvironment | 2022 |
Influence of electrode potential, pH and NAD
Topics: Electrodes; Hydrogen-Ion Concentration; L-Lactate Dehydrogenase; NAD; Oxidation-Reduction; Pyruvic Acid; Regeneration | 2022 |
Pyruvate transamination and NAD biosynthesis enable proliferation of succinate dehydrogenase-deficient cells by supporting aerobic glycolysis.
Topics: Animals; Carcinoma, Renal Cell; Cell Proliferation; Glycolysis; Kidney Neoplasms; Mice; NAD; Pyruvic Acid; Succinate Dehydrogenase | 2023 |
Impact of sodium pyruvate on the electrochemical reduction of NAD
Topics: Biomimetics; Electrolytes; NAD; Niacinamide; Oxidation-Reduction; Pyruvic Acid; Sodium | 2023 |
Fumarase activity in NAD-dependent malic enzyme, MaeA, from Escherichia coli.
Topics: Escherichia coli; Fumarate Hydratase; Fumarates; Humans; Malates; NAD; NADP; Pyruvic Acid | 2023 |
Hyperpolarized [1-
Topics: Agmatine; Animals; Brain; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Lactic Acid; Mice; Mice, Inbred ICR; NAD; Pyruvic Acid | 2023 |