pyrrolidonecarboxylic acid has been researched along with thiazolidines in 328 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 48 (14.63) | 18.7374 |
| 1990's | 141 (42.99) | 18.2507 |
| 2000's | 65 (19.82) | 29.6817 |
| 2010's | 59 (17.99) | 24.3611 |
| 2020's | 15 (4.57) | 2.80 |
| Authors | Studies |
|---|---|
| Chisari, G; Condorelli, F; di Marco, R; di Mauro, M; Girardello, R; Meroni, PL; Nicoletti, F; Speciale, AM; Uslenghi, C | 1 |
| Coppi, G; D'Adamio, L; Migliorati, G; Nicoletti, I; Riccardi, C | 1 |
| Morita, I; Murota, S; Ochi, H | 1 |
| Coppi, G; D'Adamio, F; Migliorati, G; Nicoletti, I; Pagliacci, C; Riccardi, C | 1 |
| Capsoni, F; Girardello, R; Minonzio, F; Ongari, AM; Zanussi, C | 1 |
| Forno, B; Girardello, R; Marinelli, L; Pollono, AM; Pugliese, A; Uslenghi, C | 1 |
| Coppi, G; Falcone, A; Manzardo, S | 2 |
| Auteri, A; Bova, G; Bruni, F; Di Renzo, M; Pasqui, AL; Saletti, M | 1 |
| Huang, HS; Jurima-Romet, M | 1 |
| Alfano, S; Biolchini, A; Careddu, P; Zavattini, G | 1 |
| Bauman, PF; Bray, TM; Sikorski, B; Taylor, CG | 1 |
| Banks, MF; Coloso, RM; Garcia, RA; Stipanuk, MH | 1 |
| Sharif, NA; To, ZP; Whiting, RL | 1 |
| Meredith, MJ | 1 |
| Ravindranath, V; Shivakumar, BR | 1 |
| Khoury, MD; Pereira, MA | 1 |
| Hotta, T; Kawamoto, K; Kiya, K; Kurisu, K; Mikami, T; Nakada, Y; Saito, Y; Uozumi, T; Yamada, K | 1 |
| Coloso, RM; Hirschberger, LL; Stipanuk, MH | 1 |
| Ford, JM; Hait, WN; Yang, JM | 1 |
| Fujimoto, M; Hirata, M; Ohno, K | 1 |
| Boyd, MR; Ravindranath, V | 1 |
| Aebi, S; Lauterburg, BH; Porta, P; Summer, K | 1 |
| Barchielli, M; Coppi, G | 2 |
| Deguchi, T; Mataki, Y; Naya, M; Noguchi, M; Yasuda, M | 1 |
| Baker, DH; Chung, TK; Funk, MA | 1 |
| Chung, LY; Khan, L; Schmidt, RJ | 1 |
| Ferko, AP | 1 |
| Akagi, R; Taguchi, T; Ubuka, T | 1 |
| DeGraff, W; Friedman, N; Mitchell, JB; Russo, A | 1 |
| Albright, N; DeGraff, WG; Mitchell, JB; Phillips, TL; Rajpal, R; Russo, A | 1 |
| Michel, AD; Sharif, NA; To, Z; Whiting, RL | 1 |
| Anderson, ME; Bridges, RJ; Meister, A; Underwood, M | 1 |
| Duddy, SK; Hsia, MT | 1 |
| Cooper, JA; Merrill, WW | 1 |
| Brodeur, J; Goyal, R; Tardif, R | 1 |
| Kaplowitz, N; Kuhlenkamp, J; Lu, SC; Robert, A | 1 |
| Asai, K; Funaki, C; Hayashi, T; Kuzuya, F; Kuzuya, M; Naito, M | 1 |
| Parthasarathy, R; Ramasubbu, N | 1 |
| Allen, RG; Farmer, KJ; Newton, RK; Sohal, RS; Toy, PL | 1 |
| Devoto, MA; Puente, J; Sapag-Hagar, M | 1 |
| Ferguson, AE; Kanz, MF; Moslen, MT; Whitehead, RF | 1 |
| Anderson, ME; Meister, A | 2 |
| Chopp, M; Hetzel, FW; Mesina, JE; Page, RH | 1 |
| Ambrose, F; Barbaz, B; Bittiger, H; Iyengar, S; Neale, RF; Petrack, B; Rinehart, RK; Steel, DJ; Williams, M; Wood, PL | 1 |
| Abney, NL; Maatta, EA; Perchellet, EM; Perchellet, JP | 1 |
| DeGraff, WG; Mitchell, JB; Russo, A | 1 |
| Harper, BL; Moslen, MT; Roy, D | 1 |
| Phillips, PG; Tsan, MF | 1 |
| Hayes, MA; Kim, HL; Merrill, JC; Murray, CA; Safe, S | 1 |
| Fidelus, RK | 1 |
| Bauman, PF; Bray, TM; Smith, TK | 1 |
| Carmichael, J; DeGraff, W; Friedman, N; Glatstein, E; Mitchell, JB; Russo, A; Tochner, Z | 1 |
| Brodeur, J; Goyal, R | 1 |
| Fidelus, RK; Ginouves, P; Lawrence, D; Tsan, MF | 1 |
| Nishina, H; Ohta, J; Ubuka, T | 1 |
| Bracken, WM; Klaassen, CD | 1 |
| Anderson, ME; Hwang, O; Meister, A | 1 |
| Fidelus, RK; Tsan, MF | 1 |
| Kim, HL; Merrill, J; Safe, S | 1 |
| Dierickx, PJ; Vanderwielen, C | 1 |
| Boettcher, B; Meister, A | 2 |
| Hazelton, GA; Hjelle, JJ; Klaassen, CD | 1 |
| Danis, EH; Del Vecchio, PJ; Rosano, CL; Tsan, MF | 1 |
| DeGraff, WG; Finkelstein, E; Gamson, J; Mitchell, JB; Russo, A; Spiro, IJ | 1 |
| Mitchell, JB; Russo, A | 2 |
| Funatsu, K; Inanaga, K; Teshima, S | 1 |
| Friedman, N; McPherson, S; Mitchell, JB; Russo, A | 1 |
| Bruggink, JE; Glazenburg, EJ; Mulder, GJ; Wolters-Keulemans, K | 1 |
| Bailie, MB; Hook, JB; Newton, JF; Smith, JH | 1 |
| Arison, BH; Hirschmann, R; Holly, FW; Homnick, C; Nutt, RF; Veber, DF | 1 |
| Meister, A; Williamson, JM | 1 |
| Boettcher, B; Meister, A; Williamson, JM | 1 |
| Anders, MW; Stevens, JL | 1 |
| Baruchel, S; Batist, G; Farah, R; Jamali, M; Wang, T | 1 |
| Annoni, G; Arosio, B; Cullurà, D; Gagliano, N; Santambrogio, D; Uslenghi, C | 1 |
| Deshpande, SB; Warnick, JE | 1 |
| Auld, PA; Frayer, WW; Jain, A; Madsen, DC; Mårtensson, J; Meister, A; Schwartz, MK | 1 |
| Bohets, HH; D'Haese, PC; De Broe, ME; Dierickx, PJ; Nouwen, EJ; Van der Biest, I; Van Landeghem, GF; Van Thielen, MN | 1 |
| Herzenberg, LA; Raju, PA; Roederer, M | 1 |
| Averill, L; Dando, S; Georges, D; Goldberg, D; Lederman, MM; Schmelzer, R | 1 |
| Huxtable, RJ; Yan, CC | 1 |
| Maillard, F | 1 |
| Bocchiola, G; Magni, A; Signorelli, G | 1 |
| Anders, U; Bocchiola, G; Crimella, T; Orlandi, R; Stradi, R | 1 |
| Coppi, G; Manzardo, S | 1 |
| Migliorati, G; Nicoletti, I; Riccardi, C | 1 |
| Basilico, N; Cocuzza, C; Malabarba, MG; Mattina, R; Sala, G; Taramelli, D | 1 |
| Colangelo, D; Dianzani, C; Guidotto, S; Tonso, E; Viano, I | 1 |
| Barbera, N; Bernardini, R; Cantarella, G; Chiarenza, A; Iurato, MP; Lempereur, L; Scapagnini, G; Scapagnini, U | 1 |
| Coppi, G; Falcone, A; Ieva, G; Manzardo, S; Pinzetta, A | 1 |
| Amico-Roxas, M; Bertè, F; Bussi, R; Coppi, G; Gnemi, P; Harling, RJ; Mailland, F; Manzardo, S; Massey, JE; Spencer-Briggs, DJ | 1 |
| Adams, K; Allen, JA; Brooker, PC; Coppi, G; Henderson, L; Jones, E; Mailland, F; Proudlock, RJ | 1 |
| Coppi, G; Silingardi, S | 1 |
| Coppi, G; Mailland, F; Silingardi, S | 1 |
| Biffi, M; Coppi, G; Mailland, F; Silingardi, S; Spotti, D | 1 |
| Caravaggi, M; Crema, A; Crema, F; D'Angelo, L; De Ponti, F | 1 |
| Benetti, GP; Bombelli, G; Fugazza, L; Illeni, MT; La Vecchia, G; Montalto, F; Stramba Badiale, M; Uslenghi, C | 1 |
| Caramia, G; Carnelli, V; Cera, R; Clemente, E; Corsini, A; Mei, V; Solli, R; Venturoli, V | 1 |
| Careddu, P; Corsini, A; Mei, V; Venturoli, V | 1 |
| Caramia, G; Carnelli, V; Cera, R; Clemente, E; Corsini, A; Mei, V; Ruffini, E; Solli, R; Venturoli, V | 1 |
| Cirianni, C; Dolcetti, A; Fugazza, L; Moreo, G; Orlandi, O; Piacenza, G; Pozzi, E; Rampulla, C; Scarpazza, G | 1 |
| Bariffi, F; Bertoli, L; Bisetti, A; Cardani, A; Catena, E; Ciappi, G; Grassi, V; Rocco, V; Scarpazza, G; Vaccaro, L | 1 |
| Benetti, GP; Bombelli, G; Illeni, MT; Lavecchia, G; Passera, A; Uslenghi, C | 1 |
| Careddu, P | 1 |
| Calearo, C; Conticello, S; Passali, D | 1 |
| Ciaccia, A | 1 |
| De Campora, E; De Vita, C; Esposito, S; Galletti, C; Incutti, V; Mallardi, V; Motta, G; Motta, S; Pucci, V; Salonna, F | 1 |
| Burgio, GR; De Benedetti, F; Marseglia, GL; Masarone, M; Nespoli, L; Ottolenghi, A; Pagliano, L; Serra, U; Severi, F | 1 |
| Aschner, M; Kimelberg, HK; Lash, LH; Mullaney, KJ; Wagoner, D | 1 |
| Borum, PR; Chance, M; Emgushov, RT; Jackson, JB; Kalayjian, RC; Mayer, KH; Skowron, G; Spell, SA; Webb, LS; Yen-Lieberman, B | 1 |
| Bais, R; Baker, PW; Rofe, AM | 2 |
| Bray, TM; Taylor, CG | 1 |
| Gechman, M; Story, K; Webb, LE | 1 |
| Fisher, JE; Potturi, RB; Resnick, E; Zimmerman, EF | 1 |
| Barnidge, M; Janney, CG; Neuschwander-Tetri, BA | 1 |
| Grendell, JH; Luthen, RE | 1 |
| Ensunsa, JL; Hirschberger, LL; Stipanuk, MH | 1 |
| Breborowicz, A; Martis, L; Oreopoulos, DG; Witowski, J | 1 |
| Bray, TM; Goss, PM; Nagy, LE | 1 |
| Banks, MF; Stipanuk, MH | 1 |
| Fujiyama, J; Hirayama, K; Yasutake, A | 1 |
| Hosono, K; Kobayashi, H; Mochizuki, K | 1 |
| Moog, C; Obert, G; Simon, G | 1 |
| Aldershvile, J; Anderson, ME; Boesgaard, S; Loft, S; Meister, A; Poulsen, HE | 1 |
| Broccali, GP; Coppi, G; Dal Bo, L; Silingardi, S | 1 |
| Chaudiére, J; Fougeat, S; Gerard-Monnier, D; Gourvest, JF | 1 |
| Glosson, JA; Goldberg, DI; Madsen, DC; Rowe, WB; White, RD; Wilson, DM | 1 |
| Smith, TK; Sousadias, MG | 1 |
| Coppi, G; Delfino, D; Maggioni, A; Migliorati, G; Nicoletti, I; Riccardi, C | 1 |
| Campa, M; Girardello, R; Lupetti, A; Marelli, P; Senesi, S; Uslenghi, C | 1 |
| Caloro, D; Dammacco, F; Di Stefano, R; Ranieri, G; Vacca, A | 1 |
| Eftimiadi, C; Oddera, S; Rossi, GA; Sacco, O; Silvestri, M | 1 |
| Barcellini, W; Borghi, MO; Carbonelli, V; Del Papa, N; Fain, C; Gambini, D; La Rosa, L; Meroni, PL; Minonzio, F; Piona, A | 1 |
| Auteri, A; Bova, G; Bruni, F; Di Renzo, M; Gotti, G; Pasqui, AL; Saletti, M | 1 |
| Annoni, G; Arosio, B; Gagliano, N; Santambrogio, D | 1 |
| Forman, HJ; Hu, H; Liu, RM; Robison, TW | 1 |
| Burt, M; Harrison, LE; Hochwald, SN; Rose, DM | 1 |
| Baker, ER; Baker, H; DeAngelis, B; Frank, O; Hutner, SH; Khalil, M | 1 |
| Breborowicz, A; Martis, L; Oreopoulos, DG; Patrikarea, A | 1 |
| Ida, N; Maeda, K; Miyazaki, T; Murata, Y; Nagaya, T; Sato, M; Seo, H | 1 |
| Blair, SL; Burt, ME; Rose, DM; Sachar, S | 1 |
| Becker, MI; De Ioannes, AE; Díaz, MI; Garbarino, JA; Kalergis, AM; López, CB; Sein, J | 1 |
| Auteri, A; Bova, G; Bruni, F; Chiarion, C; Di Renzo, M; Ferrì, P; Girardello, R; Pasqui, AL; Saletti, M | 1 |
| Giles, KC; Gross, CL; Smith, WJ | 1 |
| Bauer, G; Chen, P; Factor, R; Markham, R; Mitchell, J; Schwartz, DH | 1 |
| Gordon, D; Leaf, C; Rice, D; Safron, J; White, R | 1 |
| Grendell, JH; Häussinger, D; Lüthen, R; Niederau, C | 1 |
| Douglas, SD; Ho, WZ; Sison, A; Starr, SE | 1 |
| Greene, JJ; Hutter, DE; Till, BG | 1 |
| Assimos, DG; Holmes, RP; Leaf, CD; Whalen, JJ | 1 |
| Arons, MM; Bernard, GR; Morris, PE; Paz, HL; Russell, JA; Wheeler, AP; Wright, PE | 1 |
| Ali-Osman, F; Srivenugopal, KS | 1 |
| Arstrand, K; Dizdar, N; Kågedal, B; Kullman, A | 1 |
| Beani, JC; Emonet, N; Favier, A; Leccia, MT; Richard, MJ | 1 |
| Breborowicz, A; Korybalska, K; Martis, L; Moberly, J; Oreopoulos, DG; Polubinska, A; Wieczorowska-Tobis, K | 1 |
| Aviram, M; Rosenblat, M | 1 |
| Dringen, R; Hamprecht, B; Kranich, O; Sandberg, M | 1 |
| Frei, B; Gokce, N; Holbrook, M; Keaney, JF; Leaf, C; Vita, JA | 1 |
| Alpert, LC; Batist, G; Chen, X; Griffith, OW; Hayward, MA; Schecter, RL | 1 |
| Harris, C; Miller, JM; Nuttall, AL; Raphael, Y; Yamasoba, T | 1 |
| Bray, TM; Levy, MA; Sikorski, B | 1 |
| Brash, DE; Chu, E; Ju, J; Liu, M; Pelling, JC | 1 |
| Barditch-Crovo, P; Borum, P; Buier, R; Goldberg, D; Kalayjian, RC; Lederman, M; Lietman, P; Noe, D; Rowe, WB; Skowron, G | 1 |
| Alghamdi, GA; Borum, PR; Jassal, SV; Logan, J; Martis, L; Moberly, JB; Moran, JE; Mupas, L; Oreopoulos, DG; Rodela, H; Story, KO; Webb, LE; Wolfson, M | 1 |
| Anderson, ME | 1 |
| Batist, G; Carystinos, GD; Chen, X | 1 |
| Batist, G; Chen, X | 1 |
| Goddard, CM; Leaf, CD; Poon, BY; Russell, JA; Walley, KR | 1 |
| Corsi, MM; Ferrero, ME; Fulgenzi, A; Gaja, G; Maes, HH; Wasserman, K | 1 |
| Gwilt, PR; Leaf, CD; Li, XY; Radick, LE; Whalen, JJ | 1 |
| Dringen, R; Hamprecht, B | 1 |
| Averill, DA; Lord-Fontaine, S | 1 |
| Guerra, B; Perino, A; Polatti, F; Scala, M | 1 |
| Brown, RH; Cudkowicz, ME; Ellis, T; Gwilt, PR; Hayden, DL; Sexton, PM; Whalen, J | 1 |
| Di Mauro, M; Grillo, C; La Mantia, I; Mattina, T; Meroni, PL; Nicoletti, F; Xiang, M; Zaccone, P | 1 |
| Mochizuki, K | 1 |
| Hales, BF; Ozolins, TR | 2 |
| Breborowicz, A; Moberly, JB; Oreopoulos, DG; Wisniewska, J | 1 |
| Grzybowski, AE | 1 |
| Clayette, P; Dereuddre-Bosquet, N; Dormont, D; Fretier, P; Imbach, JL; Jaccard, P; Mialocq, P; Oiry, J; Puy, JY | 1 |
| Ajami, AM; Fukagawa, NK; Hercules, E | 1 |
| Bradford, BU; Brenner, D; Enomoto, N; Forman, D; Frey, W; Iimuro, Y; Kono, H; Nakagami, M; Rusyn, I; Thurman, RG; Yamashina, S | 1 |
| Dizdar, N; Kågedal, B; Kullman, A | 1 |
| Hammarqvist, F; Wernerman, J | 1 |
| Fodor, J; Gullner, G; Kömives, T; Tóbiás, I | 1 |
| Alonso-Varona, A; Bilbao, P; Calle, Y; Castro, B; del Olmo, M; Palomares, T | 1 |
| Brown, LA; Guidot, DM; Jain, L; Lois, M; Modelska, K; Moss, IM; Pittet, JF | 1 |
| Birnboim, HC; Privora, H | 1 |
| Herman, TS; Martinez, BR; Meltz, ML; Mohan, S; Natarajan, M | 1 |
| Griebel, RW; Juurlink, BH; Kamencic, H; Lyon, AW; Paterson, PG | 1 |
| An, NH; Han, MK; Jang, SI; Kim, HK; Kim, SJ; Kim, UH; Park, HJ; Park, KH; Park, KJ; Park, YR; Shin, YM | 1 |
| Bierl, C; Cap, A; Heydrick, S; Loscalzo, J; Weiss, N; Zhang, YY | 1 |
| Brown, MK; Fraley, TS; Kaetzel, RS; Reed, DJ; Will, Y | 1 |
| Alonso-Varona, A; Bilbao, J; Bilbao, P; Castro, B; del Olmo, M; Palomares, T | 1 |
| Assimos, DG; Holmes, RP; Milliner, DS; Wilson, DM | 1 |
| Aivazis, V; Hatzimichail, A; Iuga-Donca, G; Papachristou, A; Valeri, R | 1 |
| Chang, YC; Chou, MY; Huang, FM; Tai, KW; Yang, LC | 1 |
| James, TL; Macdonald, JM; Schmidlin, O | 1 |
| Frei, B; Hagen, T; Keaney, JF; Smith, A; Visioli, F; Zhang, W | 1 |
| Drozak, J; Winiarska, K | 1 |
| Chang, YC; Chou, MY; Hsieh, YS; Huang, FM; Lii, CK; Tai, KW | 1 |
| Chang, YC; Chou, MY; Tsai, CH | 1 |
| Gur, ES; Kahveci, N; Korfali, E; Ozgüç, H; Serdar, Z; Tokyay, R | 1 |
| Aksenov, ND; Efremova, TN; Gamaleĭ, IA; Kirpichnikova, KM | 1 |
| Harding, CO; Held, P | 1 |
| Bryła, J; Drozak, J; Jagielski, AK; Wegrzynowicz, M; Winiarska, K | 1 |
| Clayberger, C; Krensky, AM; Li, Q; Okada, S; Whitin, JC | 1 |
| Abe, K; Saito, F; Tokui, T; Yamada, M | 1 |
| Abe, K; Iijima, Y; Ishikawa, H; Watanabe, T | 1 |
| Baek, SY; Chung, BS; Kang, CD; Kim, JY; Kim, SD; Kim, SH; Park, KH; Park, SW | 1 |
| Bossios, A; Gourgiotis, D; Papadopoulos, NG; Saxoni-Papageorgiou, P; Zamanis, P | 1 |
| Efremova, TN; Gamaleĭ, IA; Khaĭtlina, SIu; Kirpichnikova, KM | 1 |
| Choi, IW; Im, MJ; Kim, UH; Lee, HK; Lee, KS; Lee, YC; Lim, JS; Park, HS; Park, KH; Park, SJ | 1 |
| Breborowicz, A; Oreopoulos, D; Polubinska, A; Pyda, M; Witowski, J | 1 |
| Chang, YC; Chen, YJ; Chu, SC; Hsieh, YS; Tsai, CH; Yang, SF | 1 |
| Aschner, JL; Aschner, M; Shanker, G; Syversen, T | 1 |
| Jin, SM; Kim, CY; Kim, SR; Kim, UH; Lee, KS; Lee, YC; Min, KH; Park, HS; Park, KH; Park, SJ | 1 |
| Larcombe, J | 1 |
| Alonso-Varona, A; Bilbao, P; Castro, B; del Olmo, M; Palomares, T | 1 |
| Lee, YC; Park, SJ | 1 |
| Chang, YC; Ho, YC | 2 |
| Jang, KY; Jang, YB; Kang, KP; Kim, DH; Kim, W; Lee, JE; Lee, S; Lee, SY; Moon, SO; Park, SK; Sung, MJ | 1 |
| Jin, SM; Kim, SR; Lee, KS; Lee, YC; Li, L; Min, KH; Park, HS; Park, SJ | 1 |
| Breborowicz, A; Oreopoulos, DG; Podkowka, R; Styszynski, A; Wieczorowska-Tobis, K | 1 |
| Müller, M; Urbanek-Krajnc, A; Zechmann, B; Zellnig, G | 1 |
| Breborowicz, A; Jörres, A; Ksiazek, K; Witowski, J | 1 |
| Chang, YC; Ho, YC; Huang, FM | 1 |
| Brown, LA; Guidot, DM; Otis, JS | 1 |
| Al Moundhri, MS; Ali, BH; Nemmar, A; Tag Eldin, M; Tanira, MO | 1 |
| Costa, G; García-Pascual, A; González-Herreros, M; Triguero, D | 1 |
| Brown, LA; Guidot, DM; Ritzenthaler, JD; Roman, J | 1 |
| Bernard, GR; Morris, PE; Papadakos, P; Russell, JA; Schuster, DP; Truwit, JD; Vincent, JL; Wunderink, R | 1 |
| Georgiou, CD; Patsoukis, N | 1 |
| Dikalov, S; Guidot, DM; Hart, CM; Jones, DP; Kleinhenz, DJ; Kline, ER; Liang, B; Sutliff, RL | 1 |
| Berglund, T; Greger, M; Landberg, T; Ohlsson, AB | 1 |
| Choung, SY; Du, XF; Jiang, CZ; Won, EK; Wu, CF | 1 |
| Breborowicz, A; Oreopoulos, DG; Połubinska, A; Staniszewski, R | 1 |
| Choung, SY; Du Xiao, F; Jiang, CZ; Won, EK; Wu, CF | 1 |
| Ferreira, LF; Gilliam, LA; Reid, MB | 1 |
| Guidot, DM; Otis, JS | 1 |
| Al-Salam, S; Ali, BH; Dhanasekaran, S; Nemmar, A; Sudhadevi, M | 1 |
| Farrell, G; George, J; Hou, JY; Leclercq, I; Pera, N; Phung, N | 1 |
| Li, F; Liu, W; Lu, S; Qin, F; Xiong, Z; Zhang, Y | 1 |
| Avolio, M; Becker, PD; Caruso, A; Fiorentini, S; Giagulli, C; Guzman, CA; Noerder, M | 1 |
| Alonso-Varona, A; Caramés, M; García-Alonso, I; Palomares, T | 2 |
| Saberi, M; Zaree Mahmodabady, A | 1 |
| Chang, YC; Chou, MY; Hu, CC; Lee, SS; Lee, TH | 1 |
| Ahern, J; Hodge, G; Hodge, S; Holmes, M; Jersmann, H; Matthews, G; Mukaro, V; Reynolds, PN; Shivam, A | 1 |
| Li, F; Qin, F; Qin, T; Xiong, Z; Yang, S; Zhang, Y | 1 |
| Chang, YC; Huang, FM; Lee, SS; Li, YC | 1 |
| Barba-Espín, G; Clemente-Moreno, MJ; Díaz-Vivancos, P; Hernández, JA | 1 |
| Al Moutaery, M; Al Rayes, H; Al Swailam, R; Arshaduddin, M; Elfaki, I; Khan, HA; Tariq, M | 1 |
| Geršl, V; Hašková, P; Jirkovský, E; Mertlíková-Kaiserová, H; Popelová, O; Simůnek, T; Stěrba, M; Vávrová, A | 1 |
| Blackband, SJ; Clark, MD; D'Alessandro, MA; Gamcsik, MP; Johnson, CB; Ludeman, SM; Pourdeyhimi, R; Simpson, NE; Springer, JB; Teeter, SD; Thelwall, PE | 1 |
| Hu, Z; Qi, X; Wang, L; Zhang, J; Zhu, J | 1 |
| Qi, X; Wang, L; Zhu, J | 1 |
| Ananth, S; Babu, E; Boettger, T; Coothankandaswamy, V; Ganapathy, V; Martin, PM; Smith, SB; Veeranan-Karmegam, R | 1 |
| Fan, X; Guidot, DM; Joshi, PC; Koval, M | 1 |
| Hadzi-Petrushev, N; Hristov, K; Jankulovski, N; Mladenov, M | 1 |
| Jiang, B; Lou, HG; Ruan, ZR | 1 |
| Clemente-Moreno, MJ; Díaz-Vivancos, P; Hernández, JA; Piqueras, A | 1 |
| Hao, P; Kim, DG; Kim, IH; Kim, SH; Kim, SW; Lee, SO; Lee, ST; Wang, Y | 1 |
| Hu, X; Hua, H; Li, W; Shan, F; Wan, N; Wang, B; Wang, L; Zhang, W | 1 |
| Clemente-Moreno, MJ; Díaz-Vivancos, P; Fernández-García, N; Hernández, JA; Rubio, M | 1 |
| Jeon, MS; Kim, SR; Lee, HB; Lee, KS; Lee, SJ; Lee, YC; Park, SJ; Park, SY | 1 |
| Meng, Y; Plotnikoff, NP; Shan, F; Wang, E; Wang, Q; Zhang, Z | 1 |
| Choi, J; Jang, SI; Kim, SZ; Park, KH; Shin, JH | 1 |
| Huang, JH; Huang, XH; Li, JC; Li, LJ; Shen, CL; Wang, K; Xie, XF; Zheng, QS | 1 |
| Carta, S; Rossi, GA; Silvestri, M | 1 |
| Akasaka, Y; Ishii, T; Kimura, S; Kuwano, K; Misonoo, Y; Saga, T; Saito, K; Tateda, K; Yamaguchi, K; Yoshizawa, S | 1 |
| Cai, YH; Chen, H; Chen, ZW; Du, J; Fu, Y; Huo, XX; Lu, FL; Lun, ZR; Luo, QL; Shen, JL; Song, XR; Wang, H; Wang, L; Wang, Y; Xu, XC; Xu, YH; Zhang, AM | 1 |
| Huang, B; Huang, S; Kasper, LH; Li, YQ; Lu, F; Lun, ZR; Shen, J; Wang, Y; Zhao, Y; Zheng, H | 1 |
| Arthur, PG; Boyatzis, A; Grounds, MD; Terrill, JR | 1 |
| Pavlik, JA; Simet, SM; Sisson, JH | 1 |
| Mameli, C; Zuccotti, GV | 1 |
| Chen, Q; Hu, T; Jin, X; Zeng, X; Zhao, X | 1 |
| Ananth, S; Chan, CC; Ganapathy, V; Lambert, NA; Martin, PM; Promsote, W; Shen, D; Veeranan-Karmegam, R | 1 |
| Du, W; Fu, A; Fu, X; Hu, S; Ji, J; Li, W | 1 |
| Aschner, M; Caito, SW; Chakraborty, S; Exil, V; Karki, P; Lee, E; Ping, L; Wells, KS; Yu, Y | 1 |
| Chen, H; Huo, XX; Kong, LT; Li, M; Shen, JL; Wang, WW; Zhang, Q | 1 |
| Deevska, G; Karakashian, C; Morris, AJ; Nikolova-Karakashian, MN; Peppers, B; Sunkara, M | 1 |
| Artusio, L; Caimmi, S; De Amici, M; Licari, A; Marseglia, A; Marseglia, GL; Nigrisoli, S | 1 |
| Al-Kinani, AA; Alany, RG; Calabrese, G; Naughton, DP; Pierscionek, BK; Smith, JR; Vangala, A | 1 |
| Bedogni, G; Mameli, C; Pasinato, A; Picca, M; Pisanelli, S; Zuccotti, GV | 1 |
| Buongiorno, A; Pierossi, N | 1 |
| Biasin, M; Clerici, M; Esposito, S; Garziano, M; Marchisio, P; Principi, N; Rainone, V; Rossi, M; Senatore, L; Trabattoni, D | 1 |
| Chen, Y; Dou, X; Shen, W; Su, X; Wang, Y | 1 |
| Filatova, NA; Gamaley, IA; Kirpichnikova, KM; Petrov, YP | 1 |
| Arthur, PG; Graves, JA; Grounds, MD; Pinniger, GJ; Terrill, JR | 1 |
| Chen, H; Kang, D; Liang, Y; Rao, T; Shao, Y; Shen, B; Wang, G; Wang, Q; Xiao, J | 1 |
| Hayward, A; Lakhanpaul, M; Littlejohns, P; Manikam, L; Reed, K; Schilder, A; Venekamp, RP | 1 |
| Chen, J; He, Y; Huang, J; Li, M; Lv, Y; Wang, J; Wang, K; Xu, L; Yang, J; Zheng, Q | 1 |
| Bolling, AK; Holme, JA; Morisbak, E; Samuelsen, JT; Solhaug, A | 1 |
| Blasi, F; Centanni, S; Clerici, M; Garziano, M; Mantero, M; Trabattoni, D | 1 |
| Cui, L; Dai, C; Hao, Z; Qiu, M; Qu, S; Wang, C; Zhang, R | 1 |
| Fu, AK; Fu, LQ; Hu, SL; Li, WF; Li, YL; Wang, YY; Wu, YP | 1 |
| Cui, L; Hao, Z; Qiu, M; Wang, C; Zhang, R; Zhao, L; Zhu, J | 1 |
| Brady, SF; Colosimo, DA; Milshteyn, A | 1 |
| Dalle Donne, I; Galvagni, F; Giustarini, D; Milzani, A; Rossi, R; Santucci, A; Severi, FM | 1 |
| Cai, Y; Jia, YT; Niu, H; Wang, R | 1 |
| Begier-Krasinska, B; Breborowicz, A; Hoppe, K; Mackowiak, B; Sosinska-Zawierucha, P | 1 |
| Callegari, E; Feng, S; Liu, Y; Mammenga, E; Min, JW; Qiao, F; Subedi, K; Wang, H | 1 |
| Baraldi, E; Bozzetto, S; Giordano, G; Montella, S; Pirillo, P; Poeta, M; Santamaria, F; Stocchero, M | 1 |
| Dong, X; Liu, C; Liu, X; Zhao, N; Zhu, C | 1 |
| Bugatti, A; Caccuri, F; Caruso, A; Corbellini, S; Giagulli, C; Marsico, S; Mazzuca, P; Roversi, S; Zani, A | 1 |
| Carsetti, R; Di Camillo, C; Marcellini, V; Mirante, N; Valentini, D; Villani, A | 1 |
| Canonica, GW; Feleszko, W; Kalyuzhin, O; Krenke, R; Rossi, GA; Van Gerven, L | 1 |
| Cui, J; Gao, J; Guo, W; Li, A; Wu, T; Zhou, H | 1 |
| Brindisi, G; Conte, MP; De Castro, G; Duse, M; Gori, A; Leonardi, L; Marazzato, M; Schiavi, L; Zicari, AM | 1 |
| Barone, P; Filosco, F; Finocchiaro, GG; Giugno, A; Leonardi, S; Manti, S; Papale, M; Parisi, GF | 1 |
| Leonardi, S; Manti, S; Papale, M; Parisi, GF | 1 |
| Al Basir, F; Chatterjee, AN | 1 |
| Baydoun, AR; Bourne, LE; Farrington, K; Gorog, DA; Orriss, IR; Patel, JJ; Thakur, S | 1 |
| Auricchio, A; Falasca, K; Reale, M; Tamburro, M; Ucciferri, C; Vecchiet, J; Vignale, F | 1 |
| Huang, J; Li, L; Liu, H; Wen, X; Zhang, W; Zheng, Q | 1 |
| Jafrey, SZ; Karadkhele, A; Mahashur, A; Muchhala, S; Rathod, R; Suvarna, V; Vora, A; Waghray, P | 1 |
| Antonini, S; Becherucci, P; Biasci, P; Bortone, B; Bottero, S; Caldarelli, V; Cardinale, F; Chiappini, E; Ciarcià, M; Ciofi, D; Cutrera, R; D'Elios, S; de Martino, M; Del Giudice, MM; Di Mauro, G; Doria, M; Galli, L; Gattinara, GC; Indinnimeo, L; Lo Vecchio, A; Macrì, F; Marchisio, P; Marseglia, GL; Mattina, R; Miniello, VL; Morbin, G; Motisi, MA; Novelli, A; Palamara, AT; Panatta, ML; Pasinato, A; Peroni, D; Perruccio, K; Piacentini, G; Pifferi, M; Pignataro, L; Santamaria, F; Sitzia, E; Tersigni, C; Torretta, S; Trambusti, I; Trippella, G; Valentini, D; Valentini, S; Varricchio, A; Verga, MC; Vicini, C; Villani, A; Zecca, M | 1 |
| Ding, L; Feng, CG; Luo, K; Oehlers, SH | 1 |
| Deglurkar, R; Mathew, JL; Singh, M | 1 |
15 review(s) available for pyrrolidonecarboxylic acid and thiazolidines
| Article | Year |
|---|---|
The roles of intracellular glutathione in antineoplastic chemotherapy.
Topics: Animals; Antineoplastic Agents; Buthionine Sulfoximine; Cell Survival; Glutathione; Humans; In Vitro Techniques; Methionine Sulfoximine; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1986 |
Enhancement of tissue glutathione for antioxidant and immune functions in malnutrition.
Topics: Animals; Antioxidants; Dietary Proteins; Glutathione; Immunity, Innate; Infections; Nutrition Disorders; Prodrugs; Protein-Energy Malnutrition; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Up-Regulation | 1994 |
Glutathione: an overview of biosynthesis and modulation.
Topics: Animals; Buthionine Sulfoximine; Dipeptides; Enzyme Inhibitors; Esterification; Glutamate-Cysteine Ligase; Glutathione; Glutathione Synthase; Humans; Kinetics; Oxidative Stress; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1998 |
Potential for selective modulation of glutathione in cancer chemotherapy.
Topics: Animals; Buthionine Sulfoximine; Cell Communication; Drug Resistance; Enzyme Inhibitors; Female; Gap Junctions; Glutamate-Cysteine Ligase; Glutathione; Humans; Mammary Neoplasms, Experimental; Neoplasms; Prodrugs; Pyroglutamate Hydrolase; Pyrrolidonecarboxylic Acid; Rats; Thiazoles; Thiazolidines | 1998 |
Modulation of endogenous glutathione availability.
Topics: Acetylcysteine; Animals; Cysteine; Glutamine; Glutathione; Humans; Protein Precursors; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1999 |
[Glutathione in therapy].
Topics: Animals; Cysteine; Diabetes Mellitus; Glutathione; Humans; Infections; Neurodegenerative Diseases; Oxidative Stress; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 2002 |
Urinary tract infection in children.
Topics: Anti-Bacterial Agents; Child; Child, Preschool; Female; Humans; Infant; Male; Pyelonephritis; Pyrrolidonecarboxylic Acid; Secondary Prevention; Thiazoles; Thiazolidines; Urinary Tract Infections; Vesico-Ureteral Reflux | 2005 |
Antioxidants as novel agents for asthma.
Topics: Acetylcysteine; Anti-Asthmatic Agents; Antioxidants; Asthma; Cysteine; Glutathione; Humans; Oxidative Stress; Pyrrolidonecarboxylic Acid; Reactive Oxygen Species; Thiazoles; Thiazolidines | 2006 |
Limited Evidence on the Management of Respiratory Tract Infections in Down's Syndrome: A Systematic Review.
Topics: Anti-Infective Agents; Bias; Clinical Trials as Topic; Down Syndrome; Humans; Palivizumab; Pyrrolidonecarboxylic Acid; Respiratory Tract Infections; Thiazolidines; Zinc | 2016 |
Accessing Bioactive Natural Products from the Human Microbiome.
Topics: Anti-Bacterial Agents; Bacteria; Biological Products; Humans; Indoles; Metabolomics; Metagenomics; Microbial Interactions; Microbiota; Multigene Family; Peptides, Cyclic; Pyrrolidonecarboxylic Acid; Thiazolidines | 2018 |
Pidotimod, an immunostimulant in pediatric recurrent respiratory tract infections: A meta-analysis of randomized controlled trials.
Topics: Adjuvants, Immunologic; Child; Child, Preschool; Humans; Immunity, Cellular; Immunity, Humoral; Immunoglobulins; Infant; Infant, Newborn; Pyrrolidonecarboxylic Acid; Randomized Controlled Trials as Topic; Recurrence; Respiratory Tract Infections; T-Lymphocyte Subsets; T-Lymphocytes; Thiazolidines | 2019 |
Pidotimod: a review of its pharmacological features and clinical effectiveness in respiratory tract infections.
Topics: Acute Disease; Animals; Humans; Immunologic Factors; Pyrrolidonecarboxylic Acid; Respiratory Tract Infections; Risk Factors; Thiazolidines; Treatment Outcome | 2019 |
Immunoactive preparations and regulatory responses in the respiratory tract: potential for clinical application in chronic inflammatory airway diseases.
Topics: Asthma; Cell Extracts; Chronic Disease; Humans; Immunization; Immunologic Factors; Immunomodulation; Inflammation; Probiotics; Pulmonary Disease, Chronic Obstructive; Pyrrolidonecarboxylic Acid; Respiratory System; Respiratory Tract Diseases; Rhinitis; Sinusitis; Thiazolidines | 2020 |
Pidotimod in allergic diseases.
Topics: Adaptive Immunity; Adjuvants, Immunologic; Adolescent; Asthma; Child; Child, Preschool; Chronic Urticaria; Dermatitis, Atopic; Desensitization, Immunologic; Food Hypersensitivity; Humans; Hypersensitivity; Immunity, Innate; Immunologic Factors; Pyrrolidonecarboxylic Acid; Rhinitis, Allergic; Thiazolidines | 2020 |
Whether Immunostimulants Are Effective in Susceptible Children Suffering From Recurrent Respiratory Tract Infections: A Modeling Analysis Based on Literature Aggregate Data.
Topics: Adjuvants, Immunologic; Cell Extracts; Child; Female; Humans; Male; Models, Biological; Pyrrolidonecarboxylic Acid; Respiratory Tract Infections; Thiazolidines | 2022 |
41 trial(s) available for pyrrolidonecarboxylic acid and thiazolidines
| Article | Year |
|---|---|
Pidotimod in the prophylaxis of recurrent acute tonsillitis in childhood.
Topics: Acute Disease; Adolescent; Child; Child, Preschool; Double-Blind Method; Female; Humans; Male; Pyrrolidonecarboxylic Acid; Recurrence; Thiazoles; Thiazolidines; Tonsillitis | 1992 |
Pharmacokinetics and oral bioavailability of pidotimod in humans.
Topics: Administration, Oral; Adolescent; Adult; Biological Availability; Cross-Over Studies; Double-Blind Method; Female; Half-Life; Humans; Immunologic Factors; Injections, Intramuscular; Male; Middle Aged; Protein Binding; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1994 |
Pharmacokinetics of pidotimod in elderly volunteers and in renal failure patients.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Female; Half-Life; Humans; Immunologic Factors; Injections, Intravenous; Intestinal Absorption; Male; Middle Aged; Pyrrolidonecarboxylic Acid; Renal Insufficiency; Thiazoles; Thiazolidines; Urea | 1994 |
Effect of food on the bioavailability of pidotimod in healthy volunteers.
Topics: Adult; Biological Availability; Chromatography, High Pressure Liquid; Cross-Over Studies; Food-Drug Interactions; Humans; Immunologic Factors; Male; Pyrrolidonecarboxylic Acid; Spectrophotometry, Ultraviolet; Therapeutic Equivalency; Thiazoles; Thiazolidines | 1994 |
Ex vivo evaluation of pidotimod activity on cell-mediated immunity.
Topics: Adjuvants, Immunologic; Adult; Aged; Aged, 80 and over; CD3 Complex; Double-Blind Method; Female; Humans; Immunity, Cellular; Lymphocyte Count; Male; Middle Aged; Neoplasms; Phytohemagglutinins; Pyrrolidonecarboxylic Acid; Stimulation, Chemical; T-Lymphocytes; Thiazoles; Thiazolidines | 1994 |
Efficacy and safety of pidotimod in the treatment of recurrent respiratory infections in children.
Topics: Adjuvants, Immunologic; Anti-Bacterial Agents; Chemotaxis, Leukocyte; Child; Double-Blind Method; Female; Humans; Infant; Male; Phagocytosis; Pyrrolidonecarboxylic Acid; Recurrence; Respiratory Tract Infections; Thiazoles; Thiazolidines | 1994 |
Pidotimod in the treatment of recurrent respiratory infections in paediatric patients.
Topics: Bronchitis; Child; Child, Preschool; Double-Blind Method; Female; Humans; Immunologic Factors; Laryngitis; Lymphocyte Count; Male; Otitis; Pharyngitis; Pyrrolidonecarboxylic Acid; Recurrence; Respiratory Tract Infections; Rhinitis; Thiazoles; Thiazolidines; Tracheitis | 1994 |
Therapeutic efficacy and safety of pidotimod in the treatment of urinary tract infections in children.
Topics: Anti-Infective Agents, Urinary; Chemotaxis, Leukocyte; Child; Child, Preschool; Double-Blind Method; Female; Humans; Immunologic Factors; Male; Phagocytosis; Pyrrolidonecarboxylic Acid; Recurrence; Thiazoles; Thiazolidines; Urinary Tract Infections | 1994 |
Pidotimod in the treatment of patients affected by bacterial exacerbations of chronic bronchitis.
Topics: Adult; Aged; Bronchitis; Chronic Disease; Double-Blind Method; Female; Humans; Immunologic Factors; Male; Middle Aged; Pyrrolidonecarboxylic Acid; Recurrence; Respiratory Tract Infections; Skin Tests; Sputum; T-Lymphocytes, Helper-Inducer; T-Lymphocytes, Regulatory; Thiazoles; Thiazolidines | 1994 |
Evaluation of the efficacy of pidotimod in the exacerbations in patients affected with chronic bronchitis.
Topics: Adult; Aged; Aged, 80 and over; Bacterial Infections; Bronchitis; Chronic Disease; Double-Blind Method; Female; Follow-Up Studies; Humans; Immunologic Factors; Male; Middle Aged; Pyrrolidonecarboxylic Acid; Respiratory Function Tests; Thiazoles; Thiazolidines | 1994 |
Ex vivo evaluation of pidotimod activity in patients with chronic obstructive pulmonary disease.
Topics: Adjuvants, Immunologic; Adult; Aged; Aged, 80 and over; Double-Blind Method; Female; Follow-Up Studies; Granulocytes; Humans; Lung Diseases, Obstructive; Lymphocyte Activation; Lymphocytes; Macrophages; Male; Middle Aged; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1994 |
Role of immunoactivation with pidotimod in recurrent respiratory infections in childhood.
Topics: Adjuvants, Immunologic; Adolescent; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Child; Child, Preschool; Double-Blind Method; Female; Humans; Male; Pyrrolidonecarboxylic Acid; Recurrence; Respiratory Tract Infections; Risk Factors; Thiazoles; Thiazolidines; Tonsillitis | 1994 |
Pidotimod in the management of recurrent pharyngotonsillar infections in childhood.
Topics: Adjuvants, Immunologic; Adolescent; Adult; Child; Double-Blind Method; Female; Humans; Male; Pharyngitis; Pyrrolidonecarboxylic Acid; Recurrence; Thiazoles; Thiazolidines; Tonsillitis | 1994 |
Pidotimod activity against chronic bronchitis exacerbations.
Topics: Adjuvants, Immunologic; Aged; Bronchitis; Chronic Disease; Double-Blind Method; Female; Humans; Male; Middle Aged; Patient Dropouts; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1994 |
Immunoactivity of pidotimod against episodes of recurrent tonsillitis in childhood.
Topics: Adjuvants, Immunologic; Adolescent; Anti-Bacterial Agents; Anti-Inflammatory Agents; Child; Child, Preschool; Double-Blind Method; Female; Humans; Male; Pyrrolidonecarboxylic Acid; Recurrence; Thiazoles; Thiazolidines; Tonsillitis | 1994 |
Immunoactivation by pidotimod in children with recurrent respiratory infections.
Topics: Adjuvants, Immunologic; Adolescent; Child; Child, Preschool; Double-Blind Method; Female; Humans; Interleukin-2; Leukocytes; Male; Phytohemagglutinins; Pyrrolidonecarboxylic Acid; Receptors, Interleukin-2; Recurrence; Respiratory Tract Infections; Thiazoles; Thiazolidines | 1994 |
A phase I/II trial of intravenous L-2-oxothiazolidine-4-carboxylic acid (procysteine) in asymptomatic HIV-infected subjects.
Topics: Adult; Aged; beta 2-Microglobulin; CD4-Positive T-Lymphocytes; Cysteine; Female; Glutathione; HIV Seropositivity; Humans; Infusions, Intravenous; Leukocyte Count; Male; Middle Aged; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1994 |
[Pidotimod, a new biological response modifier, is able to partially prevent immune response changes related to surgical stress].
Topics: Adjuvants, Immunologic; Adolescent; Adult; Anesthesia, General; Antibody Formation; Complement C3; Complement C4; Double-Blind Method; Female; Humans; Immune System; Immunologic Deficiency Syndromes; Interleukin-2; Lymphocyte Activation; Lymphocyte Subsets; Male; Middle Aged; Neutrophils; Phagocytosis; Pyrrolidonecarboxylic Acid; Respiratory Burst; Stress, Physiological; Surgical Procedures, Operative; Thiazoles; Thiazolidines | 1993 |
The effects of (L)-2-oxothiazolidine-4-carboxylate on urinary oxalate excretion.
Topics: Adult; Humans; Male; Oxalates; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1997 |
A trial of antioxidants N-acetylcysteine and procysteine in ARDS. The Antioxidant in ARDS Study Group.
Topics: Acetylcysteine; Adult; Antioxidants; Bilirubin; Bronchoalveolar Lavage Fluid; Cardiac Output; Cysteine; Double-Blind Method; Free Radical Scavengers; Glutathione; Humans; Middle Aged; Prospective Studies; Pyrrolidonecarboxylic Acid; Respiration, Artificial; Respiratory Distress Syndrome; Thiazoles; Thiazolidines; Time Factors | 1997 |
L-2-Oxothiazolidine-4-carboxylic acid reverses endothelial dysfunction in patients with coronary artery disease.
Topics: Administration, Oral; Aged; Arteriosclerosis; Blood Flow Velocity; Blood Glucose; Blood Pressure; Cholesterol; Coronary Disease; Cysteine; Double-Blind Method; Endothelium, Vascular; Female; Glutathione; Heart Rate; Humans; Hyperemia; Male; Middle Aged; Nitric Oxide; Nitroglycerin; Oxidation-Reduction; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Triglycerides; Ultrasonography | 1998 |
A phase I/II evaluation of oral L-2-oxothiazolidine-4-carboxylic acid in asymptomatic patients infected with human immunodeficiency virus.
Topics: Adult; Anti-HIV Agents; Cysteine; Dose-Response Relationship, Drug; Double-Blind Method; Glutathione; HIV Infections; Humans; Leukocytes, Mononuclear; Middle Aged; Prodrugs; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1998 |
Elevation of whole-blood glutathione in peritoneal dialysis patients by L-2-oxothiazolidine-4-carboxylate, a cysteine prodrug (Procysteine).
Topics: Administration, Oral; Cysteine; Double-Blind Method; Female; Glutathione; Humans; Kidney Failure, Chronic; Male; Middle Aged; Osmolar Concentration; Peritoneal Dialysis, Continuous Ambulatory; Prospective Studies; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1998 |
Pidotimod in the management of vulvar papillomatosis: double-blind clinical trial versus placebo.
Topics: Administration, Oral; Adolescent; Adult; Biopsy; Colposcopy; Condylomata Acuminata; Double-Blind Method; Female; Humans; Immunologic Factors; Middle Aged; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Treatment Outcome; Vulvar Diseases | 1998 |
The pharmacokinetics and pharmaco-dynamics of Procysteine in amyotrophic lateral sclerosis.
Topics: Administration, Oral; Adult; Amyotrophic Lateral Sclerosis; Glutathione; Humans; Infusions, Intravenous; Middle Aged; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1999 |
Prophylaxis with the novel immunomodulator pidotimod reduces the frequency and severity of upper respiratory tract infections in children with Down's syndrome.
Topics: Adolescent; Child; Child, Preschool; Down Syndrome; Female; Humans; Immunologic Factors; Incidence; Male; Pyrrolidonecarboxylic Acid; Recurrence; Respiratory Tract Infections; Severity of Illness Index; Thiazoles; Thiazolidines | 1999 |
(L)-2-oxothiazolidine-4-carboxylate in the treatment of primary hyperoxaluria type 1.
Topics: Calcium Oxalate; Calcium, Dietary; Cysteine; Female; Humans; Hyperoxaluria, Primary; Infusions, Intravenous; Male; Middle Aged; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Treatment Outcome | 2001 |
Clinical evaluation and changes of the respiratory epithelium function after administration of Pidotimod in Greek children with recurrent respiratory tract infections.
Topics: Adjuvants, Immunologic; Child; Child, Preschool; Female; Greece; Humans; Male; Mucociliary Clearance; Prospective Studies; Pyrrolidonecarboxylic Acid; Respiratory Mucosa; Respiratory Tract Infections; Thiazoles; Thiazolidines; Treatment Outcome | 2002 |
A double-blind placebo-controlled study to evaluate the safety and efficacy of L-2-oxothiazolidine-4-carboxylic acid in the treatment of patients with acute respiratory distress syndrome.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Male; Middle Aged; Pyrrolidonecarboxylic Acid; Respiratory Distress Syndrome; Thiazolidines | 2008 |
Hydrophilic interaction liquid chromatography-tandem mass spectrometry for the determination of adefovir in human plasma and its application to a pharmacokinetic study.
Topics: Adenine; Administration, Oral; Antiviral Agents; Chromatography, Liquid; Drug Stability; Humans; Limit of Detection; Male; Organophosphonates; Pyrrolidonecarboxylic Acid; Quality Control; Reference Standards; Reproducibility of Results; Tandem Mass Spectrometry; Thiazolidines; Time Factors | 2010 |
Quantitative determination of pidotimod in human plasma by liquid chromatography tandem mass spectrometry: application to a bioequivalence study.
Topics: Adjuvants, Immunologic; Area Under Curve; Asian People; Chromatography, High Pressure Liquid; Cross-Over Studies; Double-Blind Method; Half-Life; Humans; Indicators and Reagents; Pyrrolidonecarboxylic Acid; Quality Control; Reference Standards; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Therapeutic Equivalency; Thiazolidines | 2012 |
Bioequivalence evaluation of two formulations of pidotimod using a limited sampling strategy.
Topics: Administration, Oral; Adolescent; Adult; Area Under Curve; Chemistry, Pharmaceutical; Cross-Over Studies; Healthy Volunteers; Humans; Male; Models, Theoretical; Pyrrolidonecarboxylic Acid; Therapeutic Equivalency; Thiazolidines; Young Adult | 2013 |
Pidotimod may prevent recurrent respiratory infections in children.
Topics: Adjuvants, Immunologic; Child; Child, Preschool; Double-Blind Method; Female; Follow-Up Studies; Humans; Male; Pyrrolidonecarboxylic Acid; Respiratory Tract Infections; Thiazolidines; Treatment Outcome | 2014 |
Pidotimod for the prevention of acute respiratory infections in healthy children entering into daycare: A double blind randomized placebo-controlled study.
Topics: Acute Disease; Adjuvants, Immunologic; Child Day Care Centers; Double-Blind Method; Female; Humans; Immunization; Incidence; Infant; Male; Pyrrolidonecarboxylic Acid; Respiratory Tract Infections; Risk Reduction Behavior; Thiazolidines; Treatment Outcome | 2015 |
Immunomodulatory activity of pidotimod administered with standard antibiotic therapy in children hospitalized for community-acquired pneumonia.
Topics: Adjuvants, Immunologic; Adolescent; Anti-Bacterial Agents; Child; Child, Preschool; Community-Acquired Infections; Dendritic Cells; Female; Hospitalization; Humans; Immunity, Innate; Inflammation; Interleukin-12; Male; Peptides; Pneumonia; Polysaccharides, Bacterial; Pyrrolidonecarboxylic Acid; Respiratory Tract Infections; RNA, Messenger; Thiazolidines; Tumor Necrosis Factor-alpha | 2015 |
Advantage of population pharmacokinetic method for evaluating the bioequivalence and accuracy of parameter estimation of pidotimod.
Topics: Adolescent; Adult; Area Under Curve; Asian People; Cross-Over Studies; Humans; Immunologic Factors; Male; Models, Biological; Nonlinear Dynamics; Pyrrolidonecarboxylic Acid; Therapeutic Equivalency; Thiazolidines; Young Adult | 2016 |
Immunomodulatory effects of pidotimod in adults with community-acquired pneumonia undergoing standard antibiotic therapy.
Topics: Anti-Bacterial Agents; Community-Acquired Infections; Female; Hospitalization; Humans; Immunity, Innate; Immunologic Factors; Levofloxacin; Male; Middle Aged; Pneumonia; Prospective Studies; Pyrrolidonecarboxylic Acid; Thiazolidines; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha | 2017 |
Effects of pidotimod and bifidobacteria mixture on clinical symptoms and urinary metabolomic profile of children with recurrent respiratory infections: a randomized placebo-controlled trial.
Topics: Adjuvants, Immunologic; Bifidobacterium; Child; Child, Preschool; Female; Humans; Placebos; Pregnancy; Probiotics; Prospective Studies; Pyrrolidonecarboxylic Acid; Respiratory Tract Infections; Thiazolidines; Trial of Labor | 2019 |
Efficacy of Pidotimod use in treating allergic rhinitis in a pediatric population.
Topics: Adenoids; Age Factors; Child; Female; Humans; Hypertrophy; Immunologic Factors; Italy; Male; Nasal Obstruction; Pyrrolidonecarboxylic Acid; Rhinitis, Allergic; Thiazolidines; Treatment Outcome | 2020 |
Proposal for a new therapeutic high dosage of Pidotimod in children with periodic fever, aphthous stomatitis, pharyngitis, adenitis (PFAPA) syndrome: a randomized controlled study.
Topics: Betamethasone; Child; Child, Preschool; Cross-Over Studies; Familial Mediterranean Fever; Female; Glucocorticoids; Humans; Immunologic Factors; Lymphadenitis; Male; Pharyngitis; Prospective Studies; Pyrrolidonecarboxylic Acid; Stomatitis, Aphthous; Syndrome; Thiazolidines; Treatment Outcome | 2020 |
Efficacy and Safety of Pidotimod in Persistent Asthma: A Randomized Triple-Blinded Placebo-Controlled Trial.
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Asthma; Budesonide; Child; Double-Blind Method; Humans; Metered Dose Inhalers; Pyrrolidonecarboxylic Acid; Thiazolidines | 2022 |
272 other study(ies) available for pyrrolidonecarboxylic acid and thiazolidines
| Article | Year |
|---|---|
Increased rate of survival in Streptococcus pneumoniae-infected rats treated with the new immunomodulator Pidotimod.
Topics: Adjuvants, Immunologic; Animals; Male; Pneumonia, Pneumococcal; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Thiazoles; Thiazolidines | 1992 |
Pidotimod stimulates natural killer cell activity and inhibits thymocyte cell death.
Topics: Adjuvants, Immunologic; Animals; Apoptosis; Calcium; Cellular Senescence; Cytotoxicity, Immunologic; Killer Cells, Natural; Mice; Mice, Inbred C3H; Pyrrolidonecarboxylic Acid; Spleen; T-Lymphocytes; Thiazoles; Thiazolidines | 1992 |
Roles of glutathione and glutathione peroxidase in the protection against endothelial cell injury induced by 15-hydroperoxyeicosatetraenoic acid.
Topics: Animals; Antioxidants; Azoles; Buthionine Sulfoximine; Carotid Arteries; Cattle; Cells, Cultured; Endothelium, Vascular; Glutathione; Glutathione Peroxidase; Isoindoles; Kinetics; Leukotrienes; Lipid Peroxides; Maleates; Methionine Sulfoximine; Organoselenium Compounds; Oxidation-Reduction; Pyrrolidonecarboxylic Acid; Selenium; Sodium Selenite; Thiazoles; Thiazolidines | 1992 |
Immunopharmacology of Pidotimod: effect on natural killer cell activity and thymocyte cell death.
Topics: Animals; Apoptosis; Cell Death; Dexamethasone; Killer Cells, Natural; Mice; Mice, Inbred C3H; Pyrrolidonecarboxylic Acid; T-Lymphocytes; Thiazoles; Thiazolidines | 1992 |
Evaluation of the kinetics of the immunomodulating activity of Pidotimod on human neutrophils.
Topics: Adjuvants, Immunologic; Adult; Humans; Neutrophils; Phagocytosis; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1992 |
Ex vivo evaluation of Pidotimod effect on immune response.
Topics: Adjuvants, Immunologic; Adult; Chemotaxis, Leukocyte; Humans; Immunity, Cellular; Lymphocyte Activation; Male; Phytohemagglutinins; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1992 |
Activity of the new immunostimulant PGT/1A against experimental bacterial infections.
Topics: Adjuvants, Immunologic; Animals; Bacterial Infections; Male; Mice; Mice, Inbred ICR; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1992 |
Effect of Pidotimod, a new immunostimulating agent, on some aspects of immune response. In vitro study.
Topics: Adjuvants, Immunologic; Complement System Proteins; Humans; Immunity, Cellular; Lymphocyte Activation; Lymphocytes; Neutrophils; Phagocytosis; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1992 |
Enalapril hepatotoxicity in the rat. Effects of modulators of cytochrome P450 and glutathione.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Biomarkers; Biotransformation; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enalapril; Enzyme Induction; Glutathione; Inactivation, Metabolic; Liver; Liver Diseases; Male; Necrosis; Pregnenolone Carbonitrile; Protoporphyrins; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred F344; Sulfhydryl Compounds; Thiazoles; Thiazolidines | 1992 |
Elevation of lung glutathione by oral supplementation of L-2-oxothiazolidine-4-carboxylate protects against oxygen toxicity in protein-energy malnourished rats.
Topics: Administration, Oral; Animals; Body Weight; Glutathione; Lung; Magnetic Resonance Spectroscopy; Organ Size; Oxygen; Protein-Energy Malnutrition; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Thiazoles; Thiazolidines | 1992 |
Cysteine concentration regulates cysteine metabolism to glutathione, sulfate and taurine in rat hepatocytes.
Topics: Animals; Cells, Cultured; Chelating Agents; Cysteine; Glutathione; Indicators and Reagents; Liver; Male; Methionine; Phenanthrolines; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Sulfates; Taurine; Thiazoles; Thiazolidines | 1992 |
Analogs of thyrotropin-releasing hormone (TRH): receptor affinities in brains, spinal cords, and pituitaries of different species.
Topics: Animals; Binding, Competitive; Brain; Cattle; Dogs; Pituitary Gland, Anterior; Pyrrolidonecarboxylic Acid; Rabbits; Rats; Receptors, Neurotransmitter; Receptors, Thyrotropin-Releasing Hormone; Sheep; Species Specificity; Spinal Cord; Thiazolidines; Thyrotropin-Releasing Hormone | 1991 |
Glutathione and glutathione conjugate efflux from cultured liver cells.
Topics: Animals; Blotting, Western; Cell Line; Chromatography, High Pressure Liquid; Ethacrynic Acid; gamma-Glutamyltransferase; Glutathione; Glutathione Transferase; Isoxazoles; Liver; Pyrrolidonecarboxylic Acid; Rats; Thiazoles; Thiazolidines; Tumor Cells, Cultured | 1991 |
Selective modulation of glutathione in mouse brain regions and its effect on acrylamide-induced neurotoxicity.
Topics: Acrylamides; Animals; Brain; Buthionine Sulfoximine; Drug Interactions; Female; Glutathione; Glyceraldehyde-3-Phosphate Dehydrogenases; Injections, Spinal; Liver; Maleates; Methionine Sulfoximine; Mice; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1992 |
Prevention by chemopreventive agents of azoxymethane-induced foci of aberrant crypts in rat colon.
Topics: Acetylcysteine; Allyl Compounds; Animals; Anticarcinogenic Agents; Azoxymethane; Colon; Colonic Neoplasms; Dehydroepiandrosterone; Eflornithine; Ellagic Acid; Isothiocyanates; Male; Precancerous Conditions; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Sulfides; Thiazoles; Thiazolidines; Thiocyanates | 1991 |
Glutathione and cellular response of ACNU-resistant rat glioma sublines to drugs and radiation.
Topics: Animals; Buthionine Sulfoximine; Cell Line; Cell Survival; Dose-Response Relationship, Radiation; Doxorubicin; Drug Resistance; Etoposide; Glioma; Glutathione; Kinetics; Methionine Sulfoximine; Nimustine; Pyrrolidonecarboxylic Acid; Rats; Thiazoles; Thiazolidines; Vinblastine | 1991 |
Uptake and metabolism of L-2-oxo-[35S]thiazolidine-4-carboxylate by rat cells is slower than that of L-[35S]cysteine or L-[35S]methionine.
Topics: Animals; Biological Transport; Chromatography, High Pressure Liquid; Cysteine; Glutathione; In Vitro Techniques; Intestine, Small; Kidney Tubules; Liver; Male; Methionine; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Sulfur Radioisotopes; Thiazoles; Thiazolidines | 1991 |
Effect of buthionine sulfoximine on toxicity of verapamil and doxorubicin to multidrug resistant cells and to mice.
Topics: Animals; Buthionine Sulfoximine; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance; Flupenthixol; Glutathione; Methionine Sulfoximine; Mice; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Verapamil | 1991 |
Protective effect of prostaglandin A2 against menadione-induced cell injury in cultured porcine aorta endothelial cells.
Topics: Animals; Aorta; Cells, Cultured; Cysteine; Dose-Response Relationship, Drug; Endothelium, Vascular; Glutathione; Methionine; Prostaglandins A; Pyrrolidonecarboxylic Acid; Swine; Thiazoles; Thiazolidines; Time Factors; Vitamin K | 1991 |
Effect of modulators of glutathione synthesis on the hepatotoxicity of 2-methylfuran.
Topics: Alanine Transaminase; Animals; Antimetabolites; Buthionine Sulfoximine; Chemical and Drug Induced Liver Injury; Cystine; Drug Interactions; Furans; Glutathione; Male; Maleates; Methionine Sulfoximine; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Thiazoles; Thiazolidines | 1991 |
L-2-oxothiazolidine-4-carboxylic acid, a cysteine prodrug: pharmacokinetics and effects on thiols in plasma and lymphocytes in human.
Topics: Adult; Cysteine; Glutathione; Humans; Lymphocytes; Male; Middle Aged; Prodrugs; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1991 |
Simple high-performance liquid chromatographic method for the determination of PGT/1A, a new immunostimulating drug, in biological fluids.
Topics: Acetonitriles; Adjuvants, Immunologic; Adult; Chromatography, High Pressure Liquid; Humans; Injections, Intravenous; Male; Phosphates; Potassium; Potassium Compounds; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1991 |
Effects of L-2-oxothiazolidine-4-carboxylate, a cysteine pro-drug, on teratogenicity of 5-fluorouracil in mice.
Topics: Animals; Body Weight; Cystine; Drug Synergism; Female; Fluorouracil; Glutathione; Limb Deformities, Congenital; Liver; Maternal-Fetal Exchange; Mice; Mice, Inbred ICR; Pregnancy; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1990 |
L-2-oxothiazolidine-4-carboxylate as a cysteine precursor: efficacy for growth and hepatic glutathione synthesis in chicks and rats.
Topics: Administration, Oral; Animals; Chickens; Cysteine; Diet; Glutathione; Liver; Male; Pyrrolidonecarboxylic Acid; Random Allocation; Rats; Rats, Inbred Strains; Regression Analysis; Thiazoles; Thiazolidines; Weight Gain | 1990 |
Are free radicals and not quinones the haptenic species derived from urushiols and other contact allergenic mono- and dihydric alkylbenzenes? The significance of NADH, glutathione, and redox cycling in the skin.
Topics: Animals; Benzene; Benzene Derivatives; Catechols; Dermatitis, Contact; Free Radicals; Glutathione; Haptens; Male; Mice; NAD; Oxidation-Reduction; Pyrrolidonecarboxylic Acid; Quinones; Skin; Thiazoles; Thiazolidines | 1990 |
Activity of PGT/1A, a new immunostimulating drug, on macrophages and lymphocytes in immunodepressed mice.
Topics: Adjuvants, Immunologic; Animals; Bacterial Infections; Immunosuppression Therapy; Lymphocytes; Macrophages; Mice; Pyrrolidinones; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1990 |
The interaction between ethanol and cysteine on the central depressant effects of ethanol in mice.
Topics: Animals; Cysteine; Drug Synergism; Ethanol; gamma-Aminobutyric Acid; Injections, Intraventricular; Isethionic Acid; Male; Mice; Posture; Pyrrolidonecarboxylic Acid; Reflex; Thiazoles; Thiazolidines | 1990 |
Tissue contents and urinary excretion of taurine after administration of L-cysteine and L-2-oxothiazolidine-4-carboxylate to rats.
Topics: Animals; Caseins; Cysteine; Cysteine Dioxygenase; Cystine; Dietary Proteins; Dioxygenases; Injections, Intraperitoneal; Liver; Male; Oxygenases; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Taurine; Thiazoles; Thiazolidines; Tissue Distribution | 1990 |
Selective modulation of glutathione levels in human normal versus tumor cells and subsequent differential response to chemotherapy drugs.
Topics: Antineoplastic Agents; Bleomycin; Buthionine Sulfoximine; Cell Survival; Cells, Cultured; Cisplatin; Glutathione; Humans; Lung; Lung Neoplasms; Melphalan; Methionine Sulfoximine; Neoplasms; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Zinostatin | 1986 |
Modification of SR 2508 sensitization in hypoxic V79 cells by manipulation of glutathione levels.
Topics: Animals; Buthionine Sulfoximine; Cell Line; Cell Survival; Cricetinae; Etanidazole; Glutathione; Methionine Sulfoximine; Nitroimidazoles; Oxygen; Pyrrolidonecarboxylic Acid; Radiation-Sensitizing Agents; Thiazoles; Thiazolidines | 1989 |
Differential affinities of TRH analogs at the mammalian spinal cord TRH receptor: implications for therapy in spinal injuries.
Topics: Animals; Binding, Competitive; Guinea Pigs; Pyrrolidonecarboxylic Acid; Rabbits; Rats; Receptors, Neurotransmitter; Receptors, Thyrotropin-Releasing Hormone; Spinal Cord; Spinal Injuries; Thiazolidines; Thyrotropin-Releasing Hormone | 1989 |
Glutathione metabolism at the blood-cerebrospinal fluid barrier.
Topics: Animals; Antimetabolites; Biological Transport; Blood-Brain Barrier; Buthionine Sulfoximine; Choroid Plexus; Cysteine; Dipeptides; gamma-Glutamyltransferase; Glutathione; Isoxazoles; Male; Methionine Sulfoximine; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Thiazoles; Thiazolidines | 1989 |
Alteration of precocene II-induced hepatotoxicity by modulation of hepatic glutathione levels.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Benzopyrans; Buthionine Sulfoximine; Glutathione; Insecticides; Liver; Male; Methionine Sulfoximine; Plants; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Reference Values; Thiazoles; Thiazolidines | 1989 |
Modulation of endoperoxide product levels and cyclophosphamide-induced injury by glutathione repletion.
Topics: Animals; Bronchoalveolar Lavage Fluid; Cyclophosphamide; Glutathione; Lung; Lung Injury; Male; Prostaglandin Endoperoxides; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred F344; Thiazoles; Thiazolidines | 1989 |
Influence of a cysteine prodrug, L-2-oxothiazolidine-4-carboxylic acid, on the urinary elimination of mercapturic acids of ethylene oxide, dibromoethane, and acrylonitrile: a dose-effect study.
Topics: Acetylcysteine; Acrylonitrile; Animals; Ethylene Dibromide; Ethylene Oxide; Glutathione; Hydrocarbons, Brominated; Kidney; Liver; Male; Nitriles; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Thiazoles; Thiazolidines; Time Factors | 1989 |
Role of glutathione status in protection against ethanol-induced gastric lesions.
Topics: Acetylcysteine; Animals; Cysteamine; Ethanol; Gastric Mucosa; Glutathione; Male; Maleates; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Stomach Ulcer; Thiazoles; Thiazolidines | 1989 |
Protective role of intracellular glutathione against oxidized low density lipoprotein in cultured endothelial cells.
Topics: Animals; Antimetabolites; Aorta, Thoracic; Buthionine Sulfoximine; Cattle; Cell Survival; Cells, Cultured; Endothelium, Vascular; Fetus; Glutathione; Kinetics; Lipoproteins, LDL; Methionine Sulfoximine; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1989 |
Crystal structure of L-2-oxothiazolidine-4-carboxylic acid.
Topics: Crystallization; Hydrogen Bonding; Models, Molecular; Pyrrolidonecarboxylic Acid; Software; Thiazoles; Thiazolidines; X-Ray Diffraction | 1989 |
Effects of experimentally altered glutathione levels on life span, metabolic rate, superoxide dismutase, catalase and inorganic peroxides in the adult housefly, Musca domestica.
Topics: Animals; Buthionine Sulfoximine; Catalase; Energy Metabolism; Glutathione; Houseflies; Kinetics; Life Expectancy; Methionine Sulfoximine; Peroxides; Pyrrolidonecarboxylic Acid; Superoxide Dismutase; Thiazoles; Thiazolidines | 1985 |
Modulation of gamma-glutamyl cycle and glutathione levels in rat mammary gland explants.
Topics: Amidohydrolases; Animals; Buthionine Sulfoximine; Culture Techniques; Female; gamma-Glutamyltransferase; Glutamate-Cysteine Ligase; Glutathione; Mammary Glands, Animal; Methionine Sulfoximine; Peptide Synthases; Pyroglutamate Hydrolase; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Thiazoles; Thiazolidines | 1986 |
Protection by L-2-oxothiazolidine-4-carboxylate, a cysteine prodrug, against 1,1-dichloroethylene hepatotoxicity in rats is associated with decreases in toxin metabolism and cytochrome P-450.
Topics: Animals; Cytochrome P-450 Enzyme System; Dichloroethylenes; Glutathione; Hydrocarbons, Chlorinated; Liver; Male; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Thiazoles; Thiazolidines | 1989 |
Marked increase of cysteine levels in many regions of the brain after administration of 2-oxothiazolidine-4-carboxylate.
Topics: Animals; Brain; Brain Stem; Caudate Nucleus; Cerebellum; Cerebral Cortex; Cysteine; Glutathione; Hypothalamus; Male; Mice; Pons; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Thiazoles; Thiazolidines | 1989 |
Administration of L-2-oxothiazolidine-4-carboxylate increases glutathione levels in rat brain.
Topics: Animals; Brain; Glutathione; Male; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Thiazoles; Thiazolidines | 1989 |
Benzodiazepine interactions with central thyroid-releasing hormone binding sites: characterization and physiological significance.
Topics: Amygdala; Animals; Benzodiazepines; Brain; Cerebral Cortex; Chlordiazepoxide; Corpus Striatum; Cyclic GMP; Flunitrazepam; Kinetics; Male; Membranes; Midazolam; Pentobarbital; Pyrazoles; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Thyrotropin-Releasing Hormone; Sleep; Thiazolidines; Thyrotropin; Thyrotropin-Releasing Hormone | 1986 |
Effects of diverse intracellular thiol delivery agents on glutathione peroxidase activity, the ratio of reduced/oxidized glutathione, and ornithine decarboxylase induction in isolated mouse epidermal cells treated with 12-O-tetradecanoylphorbol-13-acetate
Topics: Acetylcysteine; Animals; Cells, Cultured; Ditiocarb; Epidermis; Female; Glutathione; Glutathione Peroxidase; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Oxidation-Reduction; Pyrrolidonecarboxylic Acid; Sulfhydryl Compounds; Tetradecanoylphorbol Acetate; Thiazoles; Thiazolidines | 1987 |
Glutathione depletion greatly reduces neocarzinostatin cytotoxicity in Chinese hamster V79 cells.
Topics: Animals; Antibiotics, Antineoplastic; Cell Line; Cell Survival; Chromatography, High Pressure Liquid; Cricetinae; Cricetulus; Cysteine; Glutathione; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Zinostatin | 1985 |
Effects of a cysteine precursor, L-2-oxothiazolidine-carboxylate, nutritional status, and sex on tissue glutathione and hepatic GSH-utilizing enzymes of CD-1 mice.
Topics: Animals; Cytochrome P-450 Enzyme System; Female; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Glutathione Transferase; Liver; Male; Mice; Nutritional Status; Pyrrolidonecarboxylic Acid; Sex Factors; Thiazoles; Thiazolidines | 1988 |
L-2-oxothiazolidine-4-carboxylate protects cultured endothelial cells against hyperoxia-induced injury.
Topics: Cells, Cultured; Endothelium, Vascular; Glutathione; Oxygen; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1988 |
Intracellular delivery of cysteine.
Topics: Animals; Biological Transport; Cysteine; Glutathione; Mice; Pyrrolidonecarboxylic Acid; Radioisotope Dilution Technique; Sulfur Radioisotopes; Thiazoles; Thiazolidines; Tissue Distribution | 1987 |
Role of glutathione in the toxicity of the sesquiterpene lactones hymenoxon and helenalin.
Topics: Acetylcysteine; Animals; Glutathione; Liver; Male; Mice; Mice, Inbred ICR; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred F344; Sesquiterpenes; Sesquiterpenes, Guaiane; Thiazoles; Thiazolidines; Toxins, Biological | 1988 |
The generation of oxygen radicals: a positive signal for lymphocyte activation.
Topics: Animals; Cell Line; Free Radicals; Glutathione; Lymphocyte Activation; Mercaptoethanol; Mice; Oxygen; Pyrrolidonecarboxylic Acid; Tetradecanoylphorbol Acetate; Thiazoles; Thiazolidines; Thymoma; Tumor Cells, Cultured | 1988 |
Effect of dietary protein deficiency and L-2-oxothiazolidine-4-carboxylate on the diurnal rhythm of hepatic glutathione in the rat.
Topics: Analysis of Variance; Animals; Body Weight; Circadian Rhythm; Cysteine; Diet; Glutathione; Liver; Male; Protein Deficiency; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Thiazoles; Thiazolidines; Time Factors | 1988 |
Effect of a cysteine prodrug (L-2-oxothiazolidine-4-carboxylic acid) on the metabolism and toxicity of bromobenzene: a repeated exposure study.
Topics: Acetylcysteine; Alanine Transaminase; Animals; Aspartate Aminotransferases; Bromobenzenes; Glutathione; Inactivation, Metabolic; Male; Metabolic Clearance Rate; Mice; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1987 |
Modulation of intracellular glutathione concentrations alters lymphocyte activation and proliferation.
Topics: Acridine Orange; Animals; Buthionine Sulfoximine; Cell Cycle; Concanavalin A; Flow Cytometry; Glutathione; Lymphocyte Activation; Lymphocytes; Mercaptoethanol; Methionine Sulfoximine; Mice; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Thymidine | 1987 |
Effect of L-2-oxothiazolidine-4-carboxylate administration on glutathione and cysteine concentrations in guinea pig liver and kidney.
Topics: Animals; Cysteine; Glutathione; Guinea Pigs; Kidney; Kinetics; Liver; Male; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1987 |
Induction of metallothionein in rat primary hepatocyte cultures: evidence for direct and indirect induction.
Topics: Animals; Cells, Cultured; Dexamethasone; Ethanol; Liver; Metallothionein; Metals; Potassium; Protein Biosynthesis; Pyrrolidonecarboxylic Acid; Rats; Thiazoles; Thiazolidines; Urethane | 1987 |
Intracellular cysteine and glutathione delivery systems.
Topics: Acetaminophen; Animals; Biological Transport, Active; Cysteine; Dipeptides; Glutathione; Intracellular Fluid; Kidney; Liver; Mice; Models, Biological; Pyroglutamate Hydrolase; Pyrrolidonecarboxylic Acid; Sulfur; Thiazoles; Thiazolidines | 1986 |
Enhancement of intracellular glutathione promotes lymphocyte activation by mitogen.
Topics: Animals; Buthionine Sulfoximine; Glutathione; Lymphocyte Activation; Lymphocytes; Mercaptoethanol; Methionine Sulfoximine; Mice; Mice, Inbred C57BL; Mitogens; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1986 |
Helenalin: mechanism of toxic action.
Topics: Animals; Drug Interactions; Glutathione; Liver; Male; Mice; Mice, Inbred ICR; Pyrrolidonecarboxylic Acid; Sesquiterpenes; Sesquiterpenes, Guaiane; Thiazoles; Thiazolidines; Toxins, Biological | 1986 |
Glutathione-dependent toxicity of the algicide 1-chloro-2,4-dinitrobenzene to Daphnia magna Straus.
Topics: Animals; Daphnia; Dinitrochlorobenzene; Glutathione; Pesticides; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1986 |
Synthesis of L-2-oxothiazolidine-4-carboxylic acid.
Topics: Indicators and Reagents; Pyroglutamate Hydrolase; Pyrrolidonecarboxylic Acid; Radioisotope Dilution Technique; Sulfur Radioisotopes; Thiazoles; Thiazolidines | 1985 |
Effects of cysteine pro-drugs on acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Animals; Biotransformation; Cysteine; Glucuronates; Glucuronic Acid; Glutathione; Kinetics; Liver; Liver Glycogen; Male; Mice; Phosphoadenosine Phosphosulfate; Protein Binding; Pyrrolidonecarboxylic Acid; Structure-Activity Relationship; Thiazoles; Thiazolidines | 1986 |
Enhancement of intracellular glutathione protects endothelial cells against oxidant damage.
Topics: Animals; Buthionine Sulfoximine; Cattle; Endothelium; Glucose Oxidase; Glutathione; Hydrogen Peroxide; Methionine Sulfoximine; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1985 |
The effects of cellular glutathione elevation on the oxygen enhancement ratio.
Topics: Animals; Cell Line; Cell Survival; Cricetinae; Cricetulus; Dose-Response Relationship, Radiation; Glutathione; In Vitro Techniques; Oxygen; Pyrrolidonecarboxylic Acid; Stimulation, Chemical; Thiazoles; Thiazolidines | 1985 |
Potentiation and protection of doxorubicin cytotoxicity by cellular glutathione modulation.
Topics: Animals; Buthionine Sulfoximine; Cell Line; Cell Survival; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Doxorubicin; Drug Synergism; Free Radicals; Glutathione; Methionine Sulfoximine; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1985 |
Binding of TRH, DN-1417 and MK-771 to TRH receptors in the rat brain. Relationship to their central actions.
Topics: Animals; Binding Sites; Brain; Guanosine Triphosphate; Male; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Thyrotropin-Releasing Hormone; Thiazolidines; Thyrotropin-Releasing Hormone | 1983 |
Alteration of bleomycin cytotoxicity by glutathione depletion or elevation.
Topics: Animals; Bleomycin; Buthionine Sulfoximine; Cell Line; Cell Survival; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Glutathione; Hydrogen Peroxide; Methionine Sulfoximine; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Time Factors | 1984 |
Radiation response of Chinese hamster cells after elevation of intracellular glutathione levels.
Topics: Aerobiosis; Animals; Buthionine Sulfoximine; Cell Line; Cell Survival; Cobalt; Cricetinae; Cricetulus; Cysteamine; Dose-Response Relationship, Radiation; Glutathione; Methionine Sulfoximine; Pyrrolidonecarboxylic Acid; Radiation-Protective Agents; Radiation-Sensitizing Agents; Thiazoles; Thiazolidines | 1984 |
Inhibition of glutathione efflux in the recirculating rat liver perfusion by cysteine but not by oxothiazolidine carboxylate, an intracellular cysteine precursor.
Topics: Animals; Cysteine; Glutathione; In Vitro Techniques; Kinetics; Liver; Male; Perfusion; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Thiazoles; Thiazolidines | 1984 |
Mechanism of chloroform nephrotoxicity. IV. Phenobarbital potentiation of in vitro chloroform metabolism and toxicity in rabbit kidneys.
Topics: Animals; Chloroform; Cytochrome P-450 Enzyme System; Drug Synergism; Enzyme Induction; In Vitro Techniques; Kidney; Kidney Cortex; Kidney Diseases; Male; Microsomes; p-Aminohippuric Acid; Phenobarbital; Phosgene; Pyrrolidonecarboxylic Acid; Rabbits; Tetraethylammonium; Tetraethylammonium Compounds; Thiazoles; Thiazolidines | 1984 |
Synthesis of L-2-oxothiazolidine-4-carboxylic acid.
Topics: Chlorobenzoates; Glutathione; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1984 |
Synthesis of thyrotropin-releasing hormone analogues with selective central nervous system effects.
Topics: Central Nervous System; Pyrrolidonecarboxylic Acid; Structure-Activity Relationship; Thiazolidines; Thyrotropin-Releasing Hormone; Thyroxine; Triiodothyronine | 1981 |
Stimulation of hepatic glutathione formation by administration of L-2-oxothiazolidine-4-carboxylate, a 5-oxo-L-prolinase substrate.
Topics: Amidohydrolases; Animals; Glutathione; Kidney; Kinetics; Liver; Mice; Pyroglutamate Hydrolase; Pyrrolidonecarboxylic Acid; Rats; Thiazoles; Thiazolidines | 1981 |
Intracellular cysteine delivery system that protects against toxicity by promoting glutathione synthesis.
Topics: Acetaminophen; Animals; Cysteine; Glutathione; Glutathione Synthase; Inactivation, Metabolic; Liver; Mice; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1982 |
Metabolism of haloforms to carbon monoxide. IV. studies on the reaction mechanism in vivo.
Topics: Animals; Carbon Monoxide; Carcinogens; Chloroform; Cysteine; Deuterium; Hydrocarbons, Brominated; Male; Maleates; Phenobarbital; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Thiazoles; Thiazolidines; Trihalomethanes | 1981 |
In vivo selective modulation of tissue glutathione in a rat mammary carcinoma model.
Topics: Animals; Antimetabolites, Antineoplastic; Bone Marrow; Buthionine Sulfoximine; Drug Synergism; Female; Glutathione; Kidney; Liver; Mammary Neoplasms, Experimental; Methionine Sulfoximine; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred F344; Thiazoles; Thiazolidines; Tumor Cells, Cultured | 1995 |
Gene expression for interleukin-2 and tumor necrosis factor-alpha in the spleen of old rats under physiological condition and during septic shock. Possible pharmacological modulation.
Topics: Aging; Animals; Blotting, Northern; Gene Expression Regulation; Immunologic Factors; Interleukin-2; Male; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; RNA; Shock, Septic; Spleen; Thiazoles; Thiazolidines; Tumor Necrosis Factor-alpha | 1994 |
Analogs of thyrotropin-releasing hormone in potentiating the spinal monosynaptic reflex in vitro.
Topics: Animals; In Vitro Techniques; Pyrrolidonecarboxylic Acid; Rats; Reflex, Monosynaptic; Spinal Cord; Structure-Activity Relationship; Thiazolidines; Thyrotropin-Releasing Hormone | 1994 |
L-2-oxothiazolidine-4-carboxylate, a cysteine precursor, stimulates growth and normalizes tissue glutathione concentrations in rats fed a sulfur amino acid-deficient diet.
Topics: Amino Acids, Sulfur; Animals; Bronchoalveolar Lavage Fluid; Diet; Glutathione; Growth; Liver; Lung; Lymphocytes; Male; Pyrrolidonecarboxylic Acid; Random Allocation; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidines; Weight Gain | 1995 |
Cytotoxicity of mercury compounds in LLC-PK1, MDCK and human proximal tubular cells.
Topics: Animals; Buthionine Sulfoximine; Cell Line; Dogs; Drug Interactions; Glutathione; Humans; Kidney; Kidney Tubules, Proximal; LLC-PK1 Cells; Mercury Compounds; Methionine Sulfoximine; Pyrrolidonecarboxylic Acid; Spectrophotometry, Atomic; Swine; Thiazoles; Thiazolidines | 1995 |
Glutathione precursor and antioxidant activities of N-acetylcysteine and oxothiazolidine carboxylate compared in in vitro studies of HIV replication.
Topics: Acetylcysteine; Antimetabolites; Antioxidants; Antiviral Agents; Buthionine Sulfoximine; Cells, Cultured; Free Radical Scavengers; Gene Expression Regulation, Viral; Genes, Reporter; Glutathione; HIV Long Terminal Repeat; HIV-1; Humans; Leukocytes, Mononuclear; Methionine Sulfoximine; Monocytes; Prodrugs; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Tumor Necrosis Factor-alpha; Virus Replication | 1994 |
L-2-oxothiazolidine-4-carboxylic acid (procysteine) inhibits expression of the human immunodeficiency virus and expression of the interleukin-2 receptor alpha chain.
Topics: Cells, Cultured; Dose-Response Relationship, Drug; Gene Expression; HIV Core Protein p24; HIV Infections; HIV-1; Humans; Interleukin-2; Leukocytes, Mononuclear; Lymphocyte Activation; NF-kappa B; Phytohemagglutinins; Promoter Regions, Genetic; Protein Binding; Pyrrolidonecarboxylic Acid; Receptors, Interleukin-2; T-Lymphocytes; Thiazoles; Thiazolidines; Virus Replication | 1995 |
Relationship between glutathione concentration and metabolism of the pyrrolizidine alkaloid, monocrotaline, in the isolated, perfused liver.
Topics: Analysis of Variance; Animals; Antimetabolites, Antineoplastic; Bile; Buthionine Sulfoximine; Ethylene Chlorohydrin; Glutathione; Liver; Male; Maleates; Methionine Sulfoximine; Monocrotaline; Perfusion; Pyrroles; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidines | 1995 |
Pidotimod. A new biological response modifier. Introduction.
Topics: Adjuvants, Immunologic; Animals; Bacterial Infections; Humans; Immunologic Factors; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1994 |
Synthesis and preliminary pharmacological evaluation of pidotimod, its enantiomer, diastereomers and carboxamido derivatives.
Topics: Adjuvants, Immunologic; Animals; Bacterial Infections; Immunologic Factors; Macrophages; Male; Mice; Mice, Inbred Strains; Prednisolone; Pyrrolidonecarboxylic Acid; Stereoisomerism; Structure-Activity Relationship; Superoxides; Thiazoles; Thiazolidines | 1994 |
Analytical and chemical profile of pidotimod.
Topics: Calorimetry, Differential Scanning; Chemical Phenomena; Chemistry, Physical; Chromatography, High Pressure Liquid; Crystallography, X-Ray; Immunologic Factors; Isomerism; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Weight; Pyrrolidonecarboxylic Acid; Solubility; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Thermogravimetry; Thiazoles; Thiazolidines | 1994 |
Experimental immunological screening tests on pidotimod.
Topics: Adjuvants, Immunologic; Animals; Antibody Formation; B-Lymphocytes; Chemotaxis, Leukocyte; Dinitrochlorobenzene; Graft vs Host Reaction; Hypersensitivity, Delayed; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mononuclear Phagocyte System; Organ Size; Pyrrolidonecarboxylic Acid; Sheep; Spleen; T-Lymphocytes; Thiazoles; Thiazolidines; Thymus Gland | 1994 |
Protective effects of pidotimod against experimental bacterial infections in mice.
Topics: Adjuvants, Immunologic; Animals; Anti-Bacterial Agents; Cyclophosphamide; Enterobacteriaceae Infections; Immunosuppression Therapy; Lactams; Male; Mice; Mice, Inbred Strains; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1994 |
Immunomodulating activity of pidotimod.
Topics: Adjuvants, Immunologic; Animals; Apoptosis; Calcimycin; Cell Division; DNA; Female; Flow Cytometry; Killer Cells, Natural; Male; Mice; Mice, Inbred C3H; Mitogens; Protein-Tyrosine Kinases; Pyrrolidonecarboxylic Acid; Spleen; T-Lymphocytes; Thiazoles; Thiazolidines; Tissue Plasminogen Activator; Tumor Cells, Cultured | 1994 |
Effects of pidotimod on macrophage functions in methylprednisolone-treated mice.
Topics: Adjuvants, Immunologic; Animals; Aspergillus fumigatus; Cell Adhesion; Cell Division; Cytokines; Female; Interferon-gamma; Lipopolysaccharides; Macrophages; Methylprednisolone; Mice; Mice, Inbred Strains; Nitric Oxide; Pyrrolidonecarboxylic Acid; Spores, Fungal; Thiazoles; Thiazolidines; Tumor Necrosis Factor-alpha | 1994 |
In vivo antiviral effects of pidotimod.
Topics: Adjuvants, Immunologic; Animals; Antiviral Agents; Cardiovirus Infections; Herpes Simplex; Influenza A virus; Male; Mengovirus; Mice; Orthomyxoviridae Infections; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Virus Diseases | 1994 |
Effects of pidotimod on the immune and the neuroendocrine system in the aging rat.
Topics: Adjuvants, Immunologic; Adrenocorticotropic Hormone; Aging; Animals; Cytokines; Immune System; Immunologic Factors; Interleukin-1; Lymphocytes; Male; Mitogens; Neurosecretory Systems; Pituitary-Adrenal System; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Spleen; Thiazoles; Thiazolidines | 1994 |
General pharmacology of pidotimod and testing for drug interactions.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Autonomic Nervous System; Behavior, Animal; Central Nervous System; Diuresis; Dogs; Drug Interactions; Guinea Pigs; Hemodynamics; Immunologic Factors; In Vitro Techniques; Male; Mice; Muscle, Smooth; Pyrrolidonecarboxylic Acid; Rabbits; Rats; Respiration; Thiazoles; Thiazolidines | 1994 |
Toxicological evaluation of pidotimod.
Topics: Animals; Dogs; Female; Fertility; Lethal Dose 50; Male; Mice; Mice, Inbred Strains; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Teratogens; Thiazoles; Thiazolidines | 1994 |
Genotoxicity testing of pidotimod in vitro and in vivo.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Cells, Cultured; CHO Cells; Chromosome Aberrations; Cricetinae; DNA Repair; Erythrocytes; HeLa Cells; Humans; In Vitro Techniques; Mice; Micronucleus Tests; Mutagenicity Tests; Mutagens; Pyrrolidonecarboxylic Acid; Rats; Salmonella typhimurium; Thiazoles; Thiazolidines | 1994 |
Pharmacokinetics of pidotimod in rats and dogs.
Topics: Administration, Oral; Animals; Biological Availability; Chromatography, High Pressure Liquid; Dogs; Half-Life; Immunologic Factors; Injections, Intramuscular; Injections, Intravenous; Male; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Thiazoles; Thiazolidines; Tissue Distribution | 1994 |
Intracellular glutathione (GSH) levels modulate mercuric chloride (MC)- and methylmercuric chloride (MeHgCl)-induced amino acid release from neonatal rat primary astrocytes cultures.
Topics: Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Buthionine Sulfoximine; Cells, Cultured; Glutamate-Cysteine Ligase; Glutathione; Mercuric Chloride; Methionine Sulfoximine; Methylmercury Compounds; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Stimulation, Chemical; Taurine; Thiazoles; Thiazolidines; Tritium | 1994 |
The efficacy of (L)-2-oxothiazolidine-4-carboxylate (OTC) and (L)-cysteine in reducing urinary oxalate excretion.
Topics: Animals; Calcium Oxalate; Cysteine; Male; Metabolism; Pyrrolidonecarboxylic Acid; Rats; Thiazoles; Thiazolidines; Time Factors | 1994 |
Determination of L-2-oxothiazolidine-4-carboxylic acid (Procysteine) in human plasma by high-performance liquid chromatography.
Topics: Administration, Oral; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; HIV Infections; Humans; Indicators and Reagents; Injections, Intravenous; Pyrrolidonecarboxylic Acid; Quality Control; Reference Standards; Respiratory Distress Syndrome; Spectrophotometry, Ultraviolet; Thiazoles; Thiazolidines | 1994 |
Role of oxygen free radicals in cocaine-induced vascular disruption in mice.
Topics: Abnormalities, Drug-Induced; Animals; Antioxidants; Aorta; Blood Vessels; Cocaine; Cyclic N-Oxides; Female; Fetal Diseases; Fetal Heart; Gestational Age; Hemorrhage; Lipid Peroxidation; Maternal-Fetal Exchange; Mice; Mice, Inbred ICR; Nervous System; Nervous System Malformations; Neural Tube Defects; Nitrogen Oxides; Pregnancy; Pyrrolidonecarboxylic Acid; Reactive Oxygen Species; Thiazoles; Thiazolidines; Vasodilation; Yolk Sac | 1994 |
Cerulein-induced pancreatic cysteine depletion: prevention does not diminish acute pancreatitis in the mouse.
Topics: Animals; Ceruletide; Cysteine; Dose-Response Relationship, Drug; Female; Glutathione; Mice; Mice, Inbred Strains; Pancreas; Pancreatitis; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Time Factors | 1994 |
Thiol metabolism and acute pancreatitis: trying to make the pieces fit.
Topics: Acute Disease; Animals; Ceruletide; Cysteine; Glutathione; Pancreas; Pancreatitis; Pyrrolidonecarboxylic Acid; Sulfhydryl Compounds; Thiazoles; Thiazolidines | 1994 |
Catabolism of cysteine, cystine, cysteinesulfinate, and OTC by isolated perfused rat hindquarter.
Topics: Adenine Nucleotides; Animals; Cysteine; Cystine; Hindlimb; In Vitro Techniques; Lactates; Male; Muscles; Neurotransmitter Agents; Perfusion; Phosphocreatine; Pyrrolidonecarboxylic Acid; Pyruvates; Radioisotope Dilution Technique; Rats; Rats, Sprague-Dawley; Sulfates; Sulfur Radioisotopes; Taurine; Thiazoles; Thiazolidines | 1993 |
Enhancement of viability of human peritoneal mesothelial cells with glutathione precursor: L-2-oxothiazolidine-4-carboxylate.
Topics: Amino Acids; Cell Division; Cell Survival; Cells, Cultured; Epithelial Cells; Epithelium; Free Radicals; Glutathione; Humans; L-Lactate Dehydrogenase; Peritoneum; Protein Precursors; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Thymidine | 1993 |
Regulation of hepatocyte glutathione by amino acid precursors and cAMP in protein-energy malnourished rats.
Topics: Amino Acids; Animals; Cells, Cultured; Cyclic AMP; Cysteine; Glutathione; Homeostasis; Liver; Male; Methionine; Oxygen; Protein-Energy Malnutrition; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Thiazoles; Thiazolidines | 1994 |
The utilization of N-acetylcysteine and 2-oxothiazolidine-4-carboxylate by rat hepatocytes is limited by their rate of uptake and conversion to cysteine.
Topics: Acetylcysteine; Animals; Cells, Cultured; Culture Media; Cysteine; Glutathione; Liver; Male; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Selenium Radioisotopes; Thiazoles; Thiazolidines | 1994 |
Mechanism of methylmercury efflux from cultured astrocytes.
Topics: Animals; Astrocytes; Buthionine Sulfoximine; Cells, Cultured; Cysteine; Glutathione; Methionine Sulfoximine; Methylmercury Compounds; Probenecid; Pyrrolidonecarboxylic Acid; Rats; Thiazoles; Thiazolidines | 1994 |
Purification and some properties of a novel racemase, which racemizes 2-oxothiazolidine-4-carboxylic acid and 5-oxoproline, from Flectobacillus sp. strain B-1.
Topics: Bacillus; Hydrogen-Ion Concentration; Kinetics; Pyrrolidonecarboxylic Acid; Racemases and Epimerases; Substrate Specificity; Temperature; Thiazoles; Thiazolidines | 1994 |
Effects of glutathione precursors on human immunodeficiency virus replication.
Topics: Acetylcysteine; beta-Galactosidase; Cell Line; Colorimetry; Gene Expression Regulation, Viral; Glutathione; Granulocyte-Macrophage Colony-Stimulating Factor; HIV; HIV Long Terminal Repeat; Homocysteine; Humans; Interleukin-6; Prodrugs; Pyrrolidonecarboxylic Acid; Tetradecanoylphorbol Acetate; Thiazoles; Thiazolidines; Tumor Cells, Cultured; Virus Replication | 1994 |
Nitrate tolerance in vivo is not associated with depletion of arterial or venous thiol levels.
Topics: Acetylcysteine; Animals; Arteries; Drug Tolerance; Female; Nitrates; Nitroglycerin; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Reference Values; Sulfhydryl Compounds; Thiazoles; Thiazolidines; Veins | 1994 |
A new HPLC method for pidotimod plasma levels determination.
Topics: Adult; Chromatography, High Pressure Liquid; Humans; Immunologic Factors; Male; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1993 |
Partial prevention of glutathione depletion in rats following acute intoxication with diethylmaleate.
Topics: Animals; Brain; Cysteine; Glutathione; Heart; Kidney; Liver; Male; Maleates; Myocardium; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidines | 1993 |
Toxicity evaluations of L-cysteine and Procysteine, a cysteine prodrug, given once intravenously to neonatal rats.
Topics: Animals; Animals, Newborn; Body Weight; Cysteine; Injections, Intravenous; Organ Size; Prodrugs; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidines | 1993 |
Toxicity and growth-promoting potential of spermine when fed to chicks.
Topics: Adenosylmethionine Decarboxylase; Animal Feed; Animals; Chickens; Cysteine; Diet; Dose-Response Relationship, Drug; Eating; Glutathione; Kidney; Liver; Male; Muscle, Skeletal; Ornithine; Ornithine Decarboxylase; Polyamines; Putrescine; Pyrrolidonecarboxylic Acid; Spermine; Thiazoles; Thiazolidines | 1995 |
[Pidotimod causes apoptotic cell death and inhibits the proliferative activity of YAC-1 tumor cells in vitro].
Topics: Adjuvants, Immunologic; Animals; Antineoplastic Agents; Apoptosis; Biological Transport; Calcium; Cell Division; DNA, Neoplasm; Drug Screening Assays, Antitumor; G2 Phase; Lymphoma, T-Cell; Mice; Mice, Inbred A; Mitosis; Neoplasm Proteins; Neoplastic Stem Cells; Phosphoproteins; Phosphorylation; Protein Processing, Post-Translational; Pyrrolidonecarboxylic Acid; T-Lymphocytes; Thiazoles; Thiazolidines; Tumor Cells, Cultured | 1993 |
[Potentiation of the resistance to viral and bacterial infections after pidotimod administration in mice].
Topics: Adjuvants, Immunologic; Animals; Bacterial Infections; Coxsackievirus Infections; Enterovirus B, Human; Female; Immunity, Innate; Influenza A virus; Mice; Mice, Inbred BALB C; Orthomyxoviridae Infections; Pyrrolidonecarboxylic Acid; Streptococcal Infections; Streptococcus agalactiae; Thiazoles; Thiazolidines; Virus Diseases | 1993 |
[Stimulation of B-cell immunity in the nude mice by pidotimod: immunohistochemical stucy of various lymphoid organs].
Topics: Adjuvants, Immunologic; Animals; Antibody Formation; B-Lymphocytes; Cell Differentiation; Immunoenzyme Techniques; Immunoglobulins; Immunologic Deficiency Syndromes; Intestinal Mucosa; Lung; Lymph Nodes; Lymphocyte Activation; Lymphoid Tissue; Mice; Mice, Nude; Pyrrolidonecarboxylic Acid; Spleen; Thiazoles; Thiazolidines | 1993 |
[Effect of pidotimod on phagocytosis and intracellular killing of Staphylococcus aureus by human circulating polymorphonuclear neutrophils and alveolar macrophages].
Topics: Adjuvants, Immunologic; Adolescent; Adult; Coloring Agents; Cytotoxicity, Immunologic; Female; Fluorescent Dyes; Humans; Hydrogen Peroxide; Indoles; Macrophage Activation; Macrophages, Alveolar; Male; Microscopy, Fluorescence; Neutrophils; Phagocytosis; Pyrrolidonecarboxylic Acid; Respiratory Burst; Staphylococcus aureus; Thiazoles; Thiazolidines | 1993 |
[Effect of pidotimod on the function of the human immune system: in vitro and ex vivo study].
Topics: Adjuvants, Immunologic; Administration, Oral; Adult; Aged; Aged, 80 and over; Aging; Antibody Formation; Chemotaxis, Leukocyte; Humans; Immune System; Interferon-gamma; Interleukin-1; Interleukin-2; Interleukin-6; Lymphocyte Activation; Lymphocyte Subsets; Mitogens; Muromonab-CD3; Neutrophils; Phagocytosis; Phytohemagglutinins; Pyrrolidonecarboxylic Acid; Tetradecanoylphorbol Acetate; Thiazoles; Thiazolidines | 1993 |
[Levels of interleukin-2 )IL-2 and tumor necrosis factor alpha (TNF-alpha) mRNA in aged rat spleen under physiological conditions and in septic shock: possible role of pidotimod in gene expression modulation].
Topics: Adjuvants, Immunologic; Aging; Animals; Escherichia coli Infections; Gene Expression Regulation; Interleukin-2; Male; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; RNA, Messenger; Shock, Septic; Spleen; Stimulation, Chemical; Thiazoles; Thiazolidines; Tumor Necrosis Factor-alpha | 1993 |
Increased gamma-glutamylcysteine synthetase and gamma-glutamyl transpeptidase activities enhance resistance of rat lung epithelial L2 cells to quinone toxicity.
Topics: Animals; Antioxidants; Benzoquinones; Cell Line; Drug Resistance; Epithelium; gamma-Glutamyltransferase; Glutamate-Cysteine Ligase; Glutathione; Hydroquinones; Lung; Oxidative Stress; Pyrrolidonecarboxylic Acid; Rats; Thiazoles; Thiazolidines | 1996 |
Selective glutathione repletion with oral oxothiazolidine carboxylate (OTZ) in the radiated tumor-bearing rat.
Topics: Administration, Oral; Animals; Glutathione; Kidney; Male; Oxidation-Reduction; Prodrugs; Pyroglutamate Hydrolase; Pyrrolidonecarboxylic Acid; Radiation-Protective Agents; Rats; Rats, Inbred F344; Thiazoles; Thiazolidines; Tissue Distribution | 1996 |
Antioxidant survey to assess antagonism to redox stress using a prokaryotic and an eukaryotic system.
Topics: Antioxidants; Buthionine Sulfoximine; Cysteine; Escherichia coli; Eukaryota; Free Radicals; Glutathione; Homocysteine; Methionine Sulfoximine; Oxidative Stress; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Vitamin K; Vitamin K 3 | 1996 |
L-2-Oxothiazolidine-4-carboxylate and N-acetylcysteine as precursors of intracellular glutathione in human peritoneal mesothelial cells.
Topics: Acetylcysteine; Cells, Cultured; Epithelial Cells; Epithelium; Free Radical Scavengers; Free Radicals; Glutathione; Humans; Peritoneum; Protein Precursors; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1996 |
Antioxidants inhibit tumor necrosis factor-alpha mediated stimulation of interleukin-8, monocyte chemoattractant protein-1, and collagenase expression in cultured human synovial cells.
Topics: Acetylcysteine; Antioxidants; Arthritis, Rheumatoid; Cells, Cultured; Chemokine CCL2; Collagenases; Free Radical Scavengers; Gene Expression Regulation, Enzymologic; Humans; Hydrogen Peroxide; Interleukin-8; NF-kappa B; Pyrrolidonecarboxylic Acid; RNA, Messenger; Synovial Membrane; Thiazoles; Thiazolidines; Transcription, Genetic; Tumor Necrosis Factor-alpha | 1996 |
Oral L-2-oxo-4-thiazolidine reduces bacterial translocation after radiation in the Fischer rat.
Topics: Administration, Oral; Animals; Bacteria; Bacterial Translocation; Body Weight; Buthionine Sulfoximine; Cells, Cultured; Eating; Glutathione; Jejunum; Liver; Lymph Nodes; Mesentery; Pyrrolidonecarboxylic Acid; Radiation-Protective Agents; Rats; Rats, Inbred F344; Thiazoles; Thiazolidines | 1996 |
Modulation of fatty acid oxidation alters contact hypersensitivity to urushiols: role of aliphatic chain beta-oxidation in processing and activation of urushiols.
Topics: Allergens; Animals; Carnitine O-Palmitoyltransferase; Catechols; Clofibrate; Dermatitis, Contact; Epoxy Compounds; Fatty Acids; Hypoglycemic Agents; Mice; Mice, Inbred BALB C; Oxidation-Reduction; Plant Extracts; Plants, Toxic; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Time Factors | 1997 |
The in vitro effect of Pidotimod on some immune functions in cancer patients.
Topics: Adjuvants, Immunologic; Female; Humans; Immunity, Cellular; Immunologic Factors; Interleukin-2; Leukocytes, Mononuclear; Lymphocyte Activation; Male; Neoplasms; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1997 |
L-oxothiazolidine 4-carboxylate pretreatment of isolated human peripheral blood lymphocytes reduces sulfur mustard cytotoxicity.
Topics: Antidotes; Cell Separation; Cell Survival; Drug Administration Schedule; Free Radical Scavengers; Glutathione; Humans; Lymphocytes; Mustard Gas; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Toxicity Tests | 1997 |
N-acetyl-cysteine and L-2-oxothiazolidine-4-carboxylic acid enhance contact-dependent growth of HIV in resting peripheral blood mononuclear cells (PBMC) in vitro and increase recovery of HIV from human-PBMC SCID mice.
Topics: Acetylcysteine; Animals; Anti-HIV Agents; CD2 Antigens; Cell Division; Cells, Cultured; Coculture Techniques; Down-Regulation; Female; HIV-1; Humans; Intercellular Adhesion Molecule-1; Leukocytes, Mononuclear; Male; Mice; Mice, SCID; Monocytes; Peritoneal Cavity; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Virus Replication; Zidovudine | 1997 |
Protective effects of L-2-oxothiazolidine-4-carboxylate treatment on cyclophosphamide-induced cystitis in rats.
Topics: Animals; Cyclophosphamide; Cystitis; Male; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidines | 1997 |
Beneficial effects of L-2-oxothiazolidine-4-carboxylate on cerulein pancreatitis in mice.
Topics: Amylases; Animals; Ceruletide; Disulfides; Female; Glutathione; Glutathione Disulfide; Mice; Pancreas; Pancreatitis; Pyrrolidonecarboxylic Acid; Receptors, Cholecystokinin; Reference Values; Sulfhydryl Compounds; Thiazoles; Thiazolidines | 1997 |
L-2-oxothiazolidine-4-carboxylic acid inhibits human immunodeficiency virus type 1 replication in mononuclear phagocytes and lymphocytes.
Topics: Adult; Anti-HIV Agents; Cells, Cultured; Female; Fetal Blood; HIV Infections; HIV-1; Humans; In Vitro Techniques; Infant, Newborn; Lymphocytes; Phagocytes; Pregnancy; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Virus Replication | 1997 |
Redox state changes in density-dependent regulation of proliferation.
Topics: Acetylcysteine; Buthionine Sulfoximine; Cell Division; Cell Line; Contact Inhibition; Fibroblasts; Fibrosarcoma; Glutathione; Humans; Male; Neoplasm Proteins; Oxidation-Reduction; Protein Binding; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Transcription Factors; Tumor Cells, Cultured | 1997 |
Activity and distribution of the cysteine prodrug activating enzyme, 5-oxo-L-prolinase, in human normal and tumor tissues.
Topics: Cysteine; Humans; Neoplasms; Prodrugs; Pyroglutamate Hydrolase; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1997 |
Effects on interstitial glutathione, cysteine and 5-S-cysteinyldopa of buthionine sulphoximine in human melanoma transplants.
Topics: Acetylcysteine; Animals; Antimetabolites, Antineoplastic; Buthionine Sulfoximine; Cysteine; Cysteinyldopa; Drug Interactions; Enzyme Inhibitors; Glutathione; Humans; Melanoma; Mice; Mice, Inbred BALB C; Mice, Nude; Microdialysis; Neoplasm Transplantation; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1997 |
Thiols and selenium: protective effect on human skin fibroblasts exposed to UVA radiation.
Topics: Acetylcysteine; Antioxidants; Cell Survival; Cells, Cultured; Cysteine; Dose-Response Relationship, Radiation; Female; Fibroblasts; Glutathione; Humans; Pyrrolidonecarboxylic Acid; Radiation-Protective Agents; Skin; Sodium Selenite; Surgery, Plastic; Thiazoles; Thiazolidines; Thiophenes; Ultraviolet Rays | 1997 |
Alterations of intraperitoneal inflammation by the addition of L-2-oxothiazolidine-carboxylate.
Topics: Albumins; Animals; Creatinine; Dialysis Solutions; Glutathione; Leukocytes; Male; Nitrites; Peritoneal Dialysis; Peritoneum; Peritonitis; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Thiazoles; Thiazolidines | 1997 |
Macrophage glutathione content and glutathione peroxidase activity are inversely related to cell-mediated oxidation of LDL: in vitro and in vivo studies.
Topics: Animals; Apolipoproteins E; Arteriosclerosis; Buthionine Sulfoximine; Cell Line; Glutathione; Glutathione Peroxidase; Lipoproteins, LDL; Macrophages; Macrophages, Peritoneal; Mice; Mice, Transgenic; Oxidation-Reduction; Peroxides; Pyrrolidonecarboxylic Acid; Selenium; Superoxides; Thiazoles; Thiazolidines | 1998 |
Utilization of cysteine and cysteine precursors for the synthesis of glutathione in astroglial cultures: preference for cystine.
Topics: Animals; Astrocytes; Brain; Brain Chemistry; Cell Survival; Cells, Cultured; Cystathionine; Cysteine; Cystine; gamma-Glutamyltransferase; Glutathione; Methionine; Nerve Tissue Proteins; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Thiazoles; Thiazolidines | 1998 |
Characterization of 5-oxo-L-prolinase in normal and tumor tissues of humans and rats: a potential new target for biochemical modulation of glutathione.
Topics: Animals; Female; Glutathione; Humans; Immunohistochemistry; Neoplasms; Pyroglutamate Hydrolase; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred F344; Thiazoles; Thiazolidines | 1998 |
Role of glutathione in protection against noise-induced hearing loss.
Topics: Animals; Antioxidants; Auditory Threshold; Buthionine Sulfoximine; Chromatography, High Pressure Liquid; Cochlea; Cysteine; Evoked Potentials, Auditory, Brain Stem; Female; Glutathione; Guinea Pigs; Hearing Loss, Noise-Induced; Prodrugs; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1998 |
Selective elevation of glutathione levels in target tissues with L-2-oxothiazolidine-4-carboxylate (OTC) protects against hyperoxia-induced lung damage in protein-energy malnourished rats: implications for a new treatment strategy.
Topics: Animals; Dietary Proteins; Glutathione; Hyperoxia; Lung; Male; Protein-Energy Malnutrition; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Thiazoles; Thiazolidines | 1998 |
Antioxidant action via p53-mediated apoptosis.
Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Blotting, Northern; Blotting, Western; Buthionine Sulfoximine; Cells, Cultured; Dimercaprol; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Glutathione; Mice; Oxidation-Reduction; Pyrrolidonecarboxylic Acid; Sulfhydryl Compounds; Thiazoles; Thiazolidines; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Vitamin E | 1998 |
The effect of (L)-cysteine and (L)-2-oxothiazolidine-4-carboxylic acid (OTZ) on urinary oxalate excretion: studies using a hyperoxaluric rat model.
Topics: Animals; Cysteine; Disease Models, Animal; Male; Oxalates; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Thiazoles; Thiazolidines; Urinary Calculi | 1998 |
Sensitization effect of L-2-oxothiazolidine-4-carboxylate on tumor cells to melphalan and the role of 5-oxo-L-prolinase in glutathione modulation in tumor cells.
Topics: Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Drug Synergism; Glutathione; Humans; Melphalan; Pyroglutamate Hydrolase; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Tumor Cells, Cultured | 1998 |
L-2-Oxothiazolidine-4-carboxylic acid prevents endotoxin-induced cardiac dysfunction.
Topics: Analysis of Variance; Animals; Endotoxins; Escherichia coli; Free Radicals; Glutathione; Infusions, Intravenous; Injections, Subcutaneous; Leukocyte Count; Myocardial Contraction; Myocardium; Prodrugs; Pyrrolidonecarboxylic Acid; Rabbits; Reactive Oxygen Species; Thiazoles; Thiazolidines; Tumor Necrosis Factor-alpha; Ventricular Dysfunction, Left | 1998 |
Protection by L-2-oxothiazolidine-4-carboxylic acid of hydrogen peroxide-induced CD3zeta and CD16zeta chain down-regulation in human peripheral blood lymphocytes and lymphokine-activated killer cells.
Topics: CD3 Complex; Cytoprotection; Down-Regulation; Humans; Hydrogen Peroxide; Killer Cells, Lymphokine-Activated; Lipopolysaccharides; Lymphocytes; Monocytes; Pyrrolidonecarboxylic Acid; Receptor-CD3 Complex, Antigen, T-Cell; Receptors, Antigen, T-Cell; Receptors, IgG; Signal Transduction; Thiazoles; Thiazolidines | 1998 |
Pharmacokinetics of 2-oxothiazolidine-4-carboxylate, a cysteine prodrug, and cysteine.
Topics: Adult; Cysteine; Glutathione; Humans; Infusions, Intravenous; Male; Prodrugs; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1998 |
N-acetylcysteine, but not methionine or 2-oxothiazolidine-4-carboxylate, serves as cysteine donor for the synthesis of glutathione in cultured neurons derived from embryonal rat brain.
Topics: Acetylcysteine; Animals; Brain; Cells, Cultured; Cysteine; Female; Glutathione; Methionine; Neurons; Pregnancy; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Thiazoles; Thiazolidines | 1999 |
Enhancement of cytotoxicity of hydrogen peroxide by hyperthermia in chinese hamster ovary cells: role of antioxidant defenses.
Topics: Acetylcysteine; Amitrole; Animals; Antioxidants; Buthionine Sulfoximine; Catalase; Cell Survival; CHO Cells; Cricetinae; Enzyme Inhibitors; Glutathione; Hot Temperature; Hydrogen Peroxide; Intracellular Fluid; Mesna; Oxidation-Reduction; Protective Agents; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1999 |
Purification and characterization of 5-oxo-L-prolinase from Paecilomyces varioti F-1, an ATP-dependent hydrolase active with L-2-oxothiazolidine-4-carboxylic acid.
Topics: Amidohydrolases; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Hydrogen-Ion Concentration; Paecilomyces; Pyrrolidonecarboxylic Acid; Sulfhydryl Reagents; Thiazoles; Thiazolidines | 1999 |
Post-translational regulation of AP-1 transcription factor DNA-binding activity in the rat conceptus.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carbon-Oxygen Lyases; DNA-(Apurinic or Apyrimidinic Site) Lyase; DNA-Binding Proteins; Embryo, Mammalian; Female; Genes, jun; HeLa Cells; Humans; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Mice; Mitogen-Activated Protein Kinase Kinases; Oxidative Stress; Phosphorylation; Pregnancy; Protein Biosynthesis; Protein Kinases; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidines; Transcription Factor AP-1; Tumor Cells, Cultured | 1999 |
l-2-oxothiazolidine-4-carboxylic acid modulates function of peritoneal mesothelial cells in vitro.
Topics: Cell Division; Cells, Cultured; Dialysis Solutions; Dose-Response Relationship, Drug; Epithelial Cells; Free Radicals; Glutathione; Humans; Hyaluronic Acid; Hydrogen Peroxide; In Vitro Techniques; Interleukin-6; Peritoneal Cavity; Peritoneal Dialysis; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1999 |
In vitro effect of glutathione precursors on cytotoxicity of amino acids to human mesothelial cells.
Topics: Acetylcysteine; Amino Acids; Biological Transport; Cell Membrane; Cells, Cultured; Epithelial Cells; Glutathione; Growth Inhibitors; Humans; Intracellular Fluid; Peritoneum; Potassium; Protein Precursors; Pyrrolidonecarboxylic Acid; Rubidium Radioisotopes; Thiazoles; Thiazolidines | 1999 |
Synthesis and in vitro anti-HIV activity in human monocyte-derived macrophages of 2-oxothiazolidine-4(R)-carboxylic acid derivatives.
Topics: Anti-HIV Agents; HIV-1; Humans; Macrophages; Monocytes; Pyrrolidonecarboxylic Acid; Structure-Activity Relationship; Thiazoles; Thiazolidines | 1999 |
L-2-[(13)C]oxothiazolidine-4-carboxylic acid: a probe for precursor mobilization for glutathione synthesis.
Topics: Acetaminophen; Adult; Aged; Breath Tests; Calorimetry, Indirect; Carbon Dioxide; Cysteine; Female; Glutathione; Humans; Kinetics; Male; Middle Aged; Models, Biological; Prodrugs; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 2000 |
The glutathione precursor L-2-oxothiazolidine-4-carboxylic acid protects against liver injury due to chronic enteral ethanol exposure in the rat.
Topics: Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Ethanol; Glutathione; Intubation, Gastrointestinal; Kupffer Cells; Liver; Liver Diseases; Male; Necrosis; NF-kappa B; Prodrugs; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; RNA, Messenger; Thiazoles; Thiazolidines; Time Factors; Tumor Necrosis Factor-alpha | 2000 |
Comparison of N-acetylcysteine and l-2-oxothiazolidine-4-carboxylate as cysteine deliverers and glutathione precursors in human malignant melanoma transplants in mice.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Cysteine; Cysteinyldopa; Enzyme Inhibitors; Glutathione; Humans; Melanoma; Melanoma, Experimental; Mice; Mice, Nude; Microdialysis; Neoplasm Transplantation; Protein Precursors; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Transplantation, Heterologous; Tumor Cells, Cultured | 2000 |
Elevation of glutathione level and activation of glutathione-related enzymes affect virus infection in tobacco.
Topics: Ascorbate Peroxidases; Cyclohexane Monoterpenes; Glutathione; Glutathione Reductase; Glutathione Transferase; Lipid Peroxidation; Malondialdehyde; Monoterpenes; Nicotiana; Peroxidases; Plant Diseases; Plant Leaves; Plants, Toxic; Pyrrolidonecarboxylic Acid; Terpenes; Thiazoles; Thiazolidines; Tobacco Mosaic Virus | 1999 |
Effects of L-2-oxothiazolidine-4-carboxylate on the cytotoxic activity and toxicity of cyclophosphamide in mice bearing B16F10 melanoma liver metastases.
Topics: Acrolein; Alkylation; Animals; Antineoplastic Agents, Alkylating; Biotransformation; Cell Division; Cyclophosphamide; Cysteine; Disease Progression; Drug Interactions; Drug Screening Assays, Antitumor; Female; Glutathione; Leukopenia; Liver Neoplasms; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Oxidation-Reduction; Prodrugs; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 2000 |
Ethanol ingestion via glutathione depletion impairs alveolar epithelial barrier function in rats.
Topics: Administration, Oral; Animals; Cations; Cell Membrane; Cells, Cultured; Drug Combinations; Epithelium; Ethanol; Glutathione; Ion Channels; Male; Permeability; Prodrugs; Pulmonary Alveoli; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidines | 2000 |
Depletion of intracellular glutathione reduces mutations by nitric oxide-donating drugs.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Cell Survival; Gamma Rays; Glutathione; Hypoxanthine Phosphoribosyltransferase; Mice; Mutagenesis; Mutagens; Nitric Oxide; Nitric Oxide Donors; Nitrites; Nitroglycerin; Nitroprusside; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Tumor Cells, Cultured | 2000 |
Antioxidant compounds interfere with the 3.
Topics: Acetylcysteine; Antioxidants; Ascorbic Acid; Colorimetry; Coloring Agents; Culture Media; Dithiothreitol; Kinetics; Melatonin; Mercaptoethanol; Oxidation-Reduction; Pyrrolidines; Pyrrolidonecarboxylic Acid; Reagent Kits, Diagnostic; Sulfhydryl Compounds; Tetrazolium Salts; Thiazoles; Thiazolidines; Thiocarbamates; Vitamin E | 2000 |
Promoting glutathione synthesis after spinal cord trauma decreases secondary damage and promotes retention of function.
Topics: Animals; Behavior, Animal; Glutathione; Glutathione Reductase; Male; Oxidative Stress; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Spinal Cord; Spinal Cord Compression; Spinal Cord Injuries; Thiazoles; Thiazolidines; Up-Regulation | 2001 |
Tissue-specific regulation of glutathione homeostasis and the activator protein-1 (AP-1) response in the rat conceptus.
Topics: Animals; Cytoprotection; DNA; Embryonic and Fetal Development; Female; Glutathione; Homeostasis; Oxidative Stress; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; RNA, Messenger; Thiazoles; Thiazolidines; Transcription Factor AP-1; Yolk Sac | 1999 |
Antidiabetic effect of a prodrug of cysteine, L-2-oxothiazolidine-4-carboxylic acid, through CD38 dimerization and internalization.
Topics: ADP-ribosyl Cyclase; ADP-ribosyl Cyclase 1; Animals; Antigens, CD; Antigens, Differentiation; Antioxidants; Blood Glucose; Calcium; Cell Line; Cell Separation; Cysteine; Dimerization; Disulfides; DNA, Complementary; Dose-Response Relationship, Drug; Flow Cytometry; Glucose; Green Fluorescent Proteins; HeLa Cells; Humans; Hypoglycemic Agents; Immunohistochemistry; Islets of Langerhans; Luminescent Proteins; Membrane Glycoproteins; Mice; Mice, Inbred BALB C; Microscopy, Confocal; Mutagenesis, Site-Directed; Mutation; NAD+ Nucleosidase; Oligonucleotides, Antisense; Pyrrolidonecarboxylic Acid; Signal Transduction; Thiazoles; Thiazolidines; Time Factors; Transfection | 2002 |
Cellular redox state and endothelial dysfunction in mildly hyperhomocysteinemic cystathionine beta-synthase-deficient mice.
Topics: Animals; Bradykinin; Cystathionine beta-Synthase; Dose-Response Relationship, Drug; Endothelium, Vascular; Glutathione Peroxidase; Homocysteine; Hyperhomocysteinemia; Liver; Mesentery; Methacholine Chloride; Mice; Nitric Oxide; Oxidation-Reduction; Oxidative Stress; Pyrrolidonecarboxylic Acid; Sulfhydryl Compounds; Thiazoles; Thiazolidines; Vasodilation | 2002 |
In vivo reversal of glutathione deficiency and susceptibility to in vivo dexamethasone-induced apoptosis by N-acetylcysteine and L-2-oxothiazolidine-4-carboxylic acid, but not ascorbic acid, in thymocytes from gamma-glutamyltranspeptidase-deficient knocko
Topics: Acetylcysteine; Animals; Apoptosis; Ascorbic Acid; Dexamethasone; gamma-Glutamyltransferase; Glutathione; Mice; Mice, Knockout; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Thymus Gland | 2002 |
L-2-Oxothiazolidine-4-carboxylate reverses the tumour growth-promoting effect of interleukin-2 and improves the anti-tumour efficacy of biochemotherapy in mice bearing B16 melanoma liver metastases.
Topics: Animals; Antineoplastic Agents; Cell Division; Cell Survival; Female; Glutathione; Interleukin-2; Liver; Melanoma; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Neoplasms; Neoplasms, Experimental; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Time Factors; Tumor Cells, Cultured | 2002 |
Mechanisms of cytotoxicity of nicotine in human periodontal ligament fibroblast cultures in vitro.
Topics: Analysis of Variance; Antioxidants; Buthionine Sulfoximine; Catalase; Cell Culture Techniques; Cell Division; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibroblasts; Free Radical Scavengers; Glutathione; Humans; Nicotine; Nicotinic Agonists; Periodontal Ligament; Protective Agents; Protein Biosynthesis; Proteins; Pyrrolidonecarboxylic Acid; Smoking; Statistics as Topic; Sulfhydryl Compounds; Superoxide Dismutase; Thiazoles; Thiazolidines | 2002 |
In vivo monitoring of hepatic glutathione in anesthetized rats by 13C NMR.
Topics: Animals; Carbon Isotopes; Female; Glutathione; Glycine; Liver; Magnetic Resonance Spectroscopy; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidines | 2002 |
Lipoic acid and vitamin C potentiate nitric oxide synthesis in human aortic endothelial cells independently of cellular glutathione status.
Topics: Antioxidants; Aorta; Ascorbic Acid; Endothelium, Vascular; Glutathione; Humans; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Thioctic Acid | 2002 |
Induction of c-fos expression by nicotine in human periodontal ligament fibroblasts is related to cellular thiol levels.
Topics: Analysis of Variance; Buthionine Sulfoximine; Cell Culture Techniques; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibroblasts; Gene Expression Regulation; Genes, fos; Glutathione; Humans; Nicotine; Periodontal Ligament; Protein Precursors; Pyrrolidonecarboxylic Acid; RNA, Messenger; Signal Transduction; Smoking; Sulfhydryl Compounds; Thiazoles; Thiazolidines; Time Factors; Transcription, Genetic | 2003 |
The up-regulation of cyclooxygenase-2 expression in human buccal mucosal fibroblasts by arecoline: a possible role in the pathogenesis of oral submucous fibrosis.
Topics: Arecoline; Aspirin; Buthionine Sulfoximine; Cell Culture Techniques; Cholinergic Agonists; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Endothelium, Vascular; Enzyme Inhibitors; Epithelial Cells; Fibroblasts; Glutathione; Humans; Immunohistochemistry; Isoenzymes; Matched-Pair Analysis; Membrane Proteins; Mouth Mucosa; Nitrobenzenes; Oral Submucous Fibrosis; Peroxidases; Prostaglandin-Endoperoxide Synthases; Pyrrolidonecarboxylic Acid; Sulfonamides; Thiazoles; Thiazolidines; Transcription, Genetic; Up-Regulation | 2003 |
Oxothiazolidine carboxylate provides protection against hepatocellular injury seen after porta hepatis occlusion (Pringle maneuver) under hypovolemic conditions.
Topics: Animals; Constriction; Hepatic Artery; Hypovolemia; Liver; Male; Models, Animal; Portal Vein; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Thiazoles; Thiazolidines | 2003 |
[Effect of agents changing the intracellular level of reactive oxygen species on the cell cycle phase distribution in 3T3 and 3T3SV40 cell lines].
Topics: 3T3 Cells; Acetylcysteine; Animals; Antioxidants; Apoptosis; Buthionine Sulfoximine; Cell Cycle; Cell Line, Transformed; Dose-Response Relationship, Drug; Glutathione; Mice; Pyrrolidonecarboxylic Acid; Reactive Oxygen Species; Thiazoles; Thiazolidines | 2003 |
L-2-oxothiazolidine-4-carboxylate supplementation in murine gamma-GT deficiency.
Topics: Animals; Body Weight; Dietary Supplements; gamma-Glutamyltransferase; Genotype; Glutathione; Growth Disorders; Liver; Mice; Mice, Knockout; Pyrrolidonecarboxylic Acid; Reproduction; Thiazoles; Thiazolidines | 2003 |
Relationship between gluconeogenesis and glutathione redox state in rabbit kidney-cortex tubules.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Enzyme Inhibitors; Gluconeogenesis; Glutathione; Intracellular Membranes; Kidney Cortex; Kidney Tubules; Male; Oxidation-Reduction; Pyrrolidonecarboxylic Acid; Rabbits; Thiazoles; Thiazolidines | 2003 |
Intracellular mediators of granulysin-induced cell death.
Topics: Antigens, Differentiation, T-Lymphocyte; Apoptosis; Calcium; Cell Death; Culture Media, Conditioned; Cytotoxicity, Immunologic; Down-Regulation; Fura-2; Glutathione; Humans; Intracellular Fluid; Jurkat Cells; Mitochondria; Peptides; Potassium; Protein Transport; Pyrrolidonecarboxylic Acid; Reactive Oxygen Species; Thiazoles; Thiazolidines; Up-Regulation | 2003 |
Pyroglutamyl aminopeptidase I, as a drug metabolizing enzyme, recognizes xenobiotic substrates containing L-2-oxothiazolidine-4-carboxylic acid.
Topics: Animals; Carbon; Cytosol; Escherichia coli; Humans; Hydrolysis; In Vitro Techniques; Kinetics; Liver; Mice; Nitrates; Oxygen; Pharmaceutical Preparations; Pyroglutamyl-Peptidase I; Pyrrolidonecarboxylic Acid; Rats; Substrate Specificity; Sulfur; Thiazoles; Thiazolidines; Xenobiotics | 2004 |
Bovine 5-oxo-L-prolinase: simple assay method, purification, cDNA cloning, and detection of mRNA in the coronary artery.
Topics: Amidohydrolases; Amino Acid Sequence; Animals; Cattle; Cloning, Molecular; Coronary Vessels; Cysteine; DNA, Complementary; Electrophoresis, Polyacrylamide Gel; Humans; In Vitro Techniques; Molecular Sequence Data; Nitrates; Pyrrolidonecarboxylic Acid; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Homology, Amino Acid; Species Specificity; Thiazoles; Thiazolidines; Vasodilator Agents | 2004 |
Preventive effect of antioxidants in MPTP-induced mouse model of Parkinson's disease.
Topics: Acetylcysteine; Analysis of Variance; Animals; Antioxidants; Blotting, Western; Brain; Cell Count; Cell Death; Disease Models, Animal; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Drug Interactions; Immunohistochemistry; JNK Mitogen-Activated Protein Kinases; Male; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; MPTP Poisoning; PC12 Cells; Pyrrolidonecarboxylic Acid; Rats; Thiazoles; Thiazolidines; Time Factors; Tyrosine 3-Monooxygenase | 2004 |
Immune modulator pidotimod decreases the in vitro expression of CD30 in peripheral blood mononuclear cells of atopic asthmatic and normal children.
Topics: Asthma; Child; Child, Preschool; Cytokines; Down-Regulation; Female; Humans; Hypersensitivity; Immunologic Factors; Ki-1 Antigen; Leukocytes, Mononuclear; Male; Pyrrolidonecarboxylic Acid; T-Lymphocytes, Helper-Inducer; Thiazoles; Thiazolidines | 2004 |
[Antioxidants-induced rearrangements of actin cytoskeleton in 3T3 and 3T3-SV40 fibroblasts].
Topics: 3T3 Cells; Acetylcysteine; Actin Cytoskeleton; Actins; Animals; Antioxidants; Cell Line, Transformed; Glutathione; Mice; Pyrrolidonecarboxylic Acid; Reactive Oxygen Species; Simian virus 40; Stress Fibers; Thiazoles; Thiazolidines; Time Factors | 2004 |
Blockade of airway hyperresponsiveness and inflammation in a murine model of asthma by a prodrug of cysteine, L-2-oxothiazolidine-4-carboxylic acid.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchitis; Cell Adhesion Molecules; Chemokines; Disease Models, Animal; Eosinophil Cationic Protein; Interleukins; Lung; Mice; NF-kappa B; Ovalbumin; Prodrugs; Pyrrolidonecarboxylic Acid; Reactive Oxygen Species; Thiazoles; Thiazolidines | 2004 |
L-2-oxothiazolidine-4-carboxylic acid reduces in vitro cytotoxicity of glucose degradation products.
Topics: Cell Division; Cells, Cultured; Cytosol; Epithelial Cells; Epithelium; Glucose; Hemodialysis Solutions; Humans; Interleukin-6; L-Lactate Dehydrogenase; Peritoneal Cavity; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 2004 |
Regulation of interleukin-6 expression by arecoline in human buccal mucosal fibroblasts is related to intracellular glutathione levels.
Topics: Areca; Arecoline; Buthionine Sulfoximine; Fibroblasts; Glutathione; Humans; Interleukin-6; Male; Oral Submucous Fibrosis; Polymerase Chain Reaction; Pyrrolidonecarboxylic Acid; RNA, Messenger; Thiazoles; Thiazolidines; Up-Regulation | 2004 |
Modulatory effect of glutathione status and antioxidants on methylmercury-induced free radical formation in primary cultures of cerebral astrocytes.
Topics: Animals; Animals, Newborn; Antioxidants; Astrocytes; Buthionine Sulfoximine; Cells, Cultured; Fluorescent Dyes; Free Radical Scavengers; Free Radicals; Glutathione; Indicators and Reagents; Mercury Poisoning, Nervous System; Methylmercury Compounds; Mitochondria; Oxidation-Reduction; Oxidative Stress; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidines | 2005 |
A prodrug of cysteine, L-2-oxothiazolidine-4-carboxylic acid, regulates vascular permeability by reducing vascular endothelial growth factor expression in asthma.
Topics: Animals; Asthma; Capillary Permeability; Female; Mice; Mice, Inbred BALB C; Ovalbumin; Phosphatidylinositol 3-Kinases; Phosphorylation; Prodrugs; Pyrrolidonecarboxylic Acid; Reactive Oxygen Species; Thiazoles; Thiazolidines; Thioctic Acid; Vascular Endothelial Growth Factor A | 2005 |
Cytomodulation of interleukin-2 effect by L-2-oxothiazolidine-4-carboxylate on human malignant melanoma.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Enzyme-Linked Immunosorbent Assay; Female; Glutathione; Humans; Interleukin-2; Leukocytes, Mononuclear; Melanoma; Middle Aged; Prodrugs; Pyrrolidonecarboxylic Acid; Receptors, Interleukin-2; Recombinant Proteins; Thiazolidines | 2006 |
Regulation of nicotine-induced cyclooxygenase-2 protein expression in human gingival fibroblasts.
Topics: Buthionine Sulfoximine; Cells, Cultured; Cyclooxygenase 2; Dose-Response Relationship, Drug; Enzyme Induction; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Flavonoids; Gingiva; Humans; Lactate Dehydrogenases; Nicotine; Phosphorylation; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 2006 |
Protective role of L-2-oxothiazolidine-4-carboxylic acid in cisplatin-induced renal injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigens, Differentiation; Antioxidants; Apoptosis; Caspase 3; Cell Line; Chemokine CCL2; Cisplatin; Cystine; Drug Evaluation, Preclinical; Gene Expression Regulation; Glutathione; Humans; Intercellular Adhesion Molecule-1; Kidney; Kidney Diseases; Kidney Function Tests; Kidney Tubules, Proximal; Macrophages; Male; Mice; Mice, Inbred C57BL; Oxidative Stress; Prodrugs; Protein Transport; Pyroglutamate Hydrolase; Pyrrolidonecarboxylic Acid; Superoxide Dismutase; Thiazolidines; Transcription Factor RelA | 2006 |
An antioxidant modulates expression of receptor activator of NF-kappaB in asthma.
Topics: Animals; Antioxidants; Asthma; Blotting, Western; Bronchoalveolar Lavage Fluid; Capillary Permeability; Female; Gene Expression; Glycoproteins; Immunohistochemistry; Mice; Mice, Inbred C57BL; Osteoprotegerin; Ovalbumin; Phosphorylation; Prodrugs; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrrolidonecarboxylic Acid; Reactive Oxygen Species; Receptors, Cytoplasmic and Nuclear; Receptors, Tumor Necrosis Factor; Receptors, Vascular Endothelial Growth Factor; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiazoles; Thiazolidines; Vascular Endothelial Growth Factor A | 2006 |
Effects of glutathione supplementation during peritoneal dialysis.
Topics: Animals; Cells, Cultured; Collagen; Epithelium; Erythrocytes; Glutathione Peroxidase; Hemodialysis Solutions; Male; Peritoneal Dialysis; Peritoneum; Proteins; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Thiazoles; Thiazolidines; Tissue Adhesions | 2006 |
Artificial elevation of glutathione affects symptom development in ZYMV-infected Cucurbita pepo L. plants.
Topics: Antiviral Agents; Chromatography, High Pressure Liquid; Cotyledon; Cucurbita; Cytosol; Glutathione; Microscopy, Immunoelectron; Peroxisomes; Plant Diseases; Plant Leaves; Plant Roots; Potyvirus; Pyrrolidonecarboxylic Acid; Thiazolidines | 2007 |
Oxidative stress contributes to accelerated development of the senescent phenotype in human peritoneal mesothelial cells exposed to high glucose.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Cells, Cultured; Cellular Senescence; Deoxyguanosine; Dose-Response Relationship, Drug; Epithelium; Glucose; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Glutathione Synthase; Humans; Oxidative Stress; Peritoneal Cavity; Phenotype; Pyrrolidonecarboxylic Acid; Reactive Oxygen Species; Thiazolidines | 2007 |
Effects of a bacterial lipid byproduct on human pulp fibroblasts in vitro.
Topics: Bacteria; Buthionine Sulfoximine; Butyrates; Cell Cycle; Cell Division; Cell Proliferation; Cells, Cultured; Dental Pulp; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibroblasts; Flow Cytometry; Fluorescence; G2 Phase; Glutathione; Humans; Lipolysis; Protein Precursors; Proteins; Pyrrolidonecarboxylic Acid; Thiazolidines | 2007 |
Cytotoxicity of formaldehyde on human osteoblastic cells is related to intracellular glutathione levels.
Topics: Buthionine Sulfoximine; Cell Line; Cell Proliferation; Formaldehyde; Glutathione; Humans; Osteoblasts; Pyrrolidonecarboxylic Acid; Root Canal Filling Materials; Thiazolidines | 2007 |
Oxidant-induced atrogin-1 and transforming growth factor-beta1 precede alcohol-related myopathy in rats.
Topics: Alcoholism; Animals; Antioxidants; Biomarkers; Central Nervous System Depressants; Disease Models, Animal; Disease Progression; Ethanol; Glutathione; Male; Muscle Proteins; Muscle, Skeletal; Muscular Atrophy; Muscular Diseases; Oxidants; Oxidation-Reduction; Oxidative Stress; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; RNA, Messenger; SKP Cullin F-Box Protein Ligases; Thiazolidines; Transforming Growth Factor beta1; Up-Regulation | 2007 |
The ameliorative effect of cysteine prodrug L-2-oxothiazolidine-4-carboxylic acid on cisplatin-induced nephrotoxicity in rats.
Topics: Acetylglucosaminidase; Administration, Oral; Animals; Antineoplastic Agents; Antioxidants; Cisplatin; Creatinine; Glutathione; Kidney Cortex; Kidney Diseases; Male; Osmolar Concentration; Prodrugs; Pyrrolidonecarboxylic Acid; Random Allocation; Rats; Rats, Wistar; Superoxide Dismutase; Thiazolidines; Urea | 2007 |
Localization and thiol dependancy of endogenous nitro compounds-mediating urethral photo-relaxation.
Topics: Animals; Animals, Newborn; Buthionine Sulfoximine; Citrulline; Electric Stimulation; Endothelium, Vascular; Enzyme Inhibitors; Ethacrynic Acid; Female; Fluoresceins; Fluorescent Dyes; Glutathione; In Vitro Techniques; Light; Microscopy, Fluorescence; Muscle Relaxation; Muscle, Smooth; Nitrergic Neurons; Nitric Oxide; Nitric Oxide Synthase Type I; Photolysis; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; S-Nitrosoglutathione; Sheep; Sulfhydryl Compounds; Thiazolidines; Thiourea; Urethra | 2008 |
Alveolar type II cells from ethanol-fed rats produce a fibronectin-enriched extracellular matrix that promotes monocyte activation.
Topics: Acetylcysteine; Alcohol Drinking; Animals; Antioxidants; Cells, Cultured; Central Nervous System Depressants; Ethanol; Extracellular Matrix; Fibronectins; Humans; Interleukin-1beta; Male; Models, Animal; Monocytes; Oxidative Stress; Pulmonary Alveoli; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Thiazolidines; Time Factors; U937 Cells | 2007 |
Differentiation of Sclerotinia minor depends on thiol redox state and oxidative stress.
Topics: Acetylcysteine; Antioxidants; Ascomycota; DNA Fragmentation; Glutathione; Growth Inhibitors; Hyphae; Lipid Peroxidation; Lipid Peroxides; Oxidation-Reduction; Oxidative Stress; Pyrrolidonecarboxylic Acid; Sulfhydryl Compounds; Thiazolidines | 2008 |
Vascular oxidative stress and nitric oxide depletion in HIV-1 transgenic rats are reversed by glutathione restoration.
Topics: Acetylcholine; Animals; Animals, Genetically Modified; Antioxidants; Aorta; Biopterins; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Endothelium, Vascular; Glutathione; HIV Infections; HIV-1; Human Immunodeficiency Virus Proteins; Male; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase Type III; Nitroprusside; Oxidative Stress; Proviruses; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred F344; Superoxides; Thiazolidines; Tyrosine; Vasodilation; Vasodilator Agents; Xanthine Oxidase | 2008 |
Increased metal tolerance in Salix by nicotinamide and nicotinic acid.
Topics: Acetylcysteine; Adaptation, Physiological; Analysis of Variance; Buthionine Sulfoximine; Cadmium; Chromatography, High Pressure Liquid; Copper; Enzyme Inhibitors; Glutathione; Metals; Niacin; Niacinamide; Pyrrolidonecarboxylic Acid; Salix; Thiazolidines; Zinc | 2008 |
Synergistic immunostimulating activity of pidotimod and red ginseng acidic polysaccharide against cyclophosphamide-induced immunosuppression.
Topics: Adjuvants, Immunologic; Animals; Body Weight; C-Reactive Protein; Cell Proliferation; Cell Survival; Cyclophosphamide; Drug Synergism; Immunosuppressive Agents; Killer Cells, Natural; Macrophages, Peritoneal; Male; Mice; Mice, Inbred BALB C; Nitric Oxide; Organ Size; Panax; Polysaccharides; Pyrrolidonecarboxylic Acid; Spleen; Tetrazolium Salts; Thiazoles; Thiazolidines | 2008 |
Normal saline induces oxidative stress in peritoneal mesothelial cells.
Topics: Cells, Cultured; Contraindications; Epithelial Cells; Fibrinolysis; Glutathione; Humans; Omentum; Osmolar Concentration; Oxidative Stress; Peritoneal Cavity; Peritoneal Diseases; Pyrrolidonecarboxylic Acid; Reactive Oxygen Species; Sodium Chloride; Solutions; Therapeutic Irrigation; Thiazolidines; Thromboplastin; Tissue Adhesions | 2008 |
Synergistic immunostimulatory effect of pidotimod and red ginseng acidic polysaccharide on humoral immunity of immunosuppressed mice.
Topics: Adjuvants, Immunologic; Alanine Transaminase; Animals; Antibody Formation; Antineoplastic Agents, Alkylating; Cell Count; Cyclophosphamide; Drug Synergism; Erythrocytes; Female; Immunoglobulin E; Immunoglobulin G; Immunosuppression Therapy; Kidney Function Tests; Leukocytes; Liver Function Tests; Lymph Nodes; Mice; Mice, Inbred BALB C; Panax; Plant Extracts; Polysaccharides; Pyrrolidonecarboxylic Acid; Spleen; Thiazolidines; Thymus Gland | 2008 |
L-2-Oxothiazolidine-4-carboxylate reverses glutathione oxidation and delays fatigue of skeletal muscle in vitro.
Topics: Acetylcysteine; Animals; Antioxidants; Diaphragm; Fatigue; Free Radical Scavengers; Glutathione Disulfide; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Oxidation-Reduction; Oxidative Stress; Pyrrolidonecarboxylic Acid; Thiazolidines | 2009 |
Procysteine stimulates expression of key anabolic factors and reduces plantaris atrophy in alcohol-fed rats.
Topics: Alcohol Drinking; Animals; Ethanol; Male; Muscle, Skeletal; Muscular Atrophy; Oxidative Stress; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Thiazolidines | 2009 |
Pulmonary exposure to diesel exhaust particles promotes cerebral microvessel thrombosis: protective effect of a cysteine prodrug l-2-oxothiazolidine-4-carboxylic acid.
Topics: Air Pollutants; Animals; Dose-Response Relationship, Drug; Intracranial Thrombosis; Lung; Male; Mice; Mice, Inbred Strains; Microvessels; Particle Size; Prodrugs; Protective Agents; Pyrrolidonecarboxylic Acid; Thiazolidines; Vehicle Emissions | 2009 |
Pro-oxidant-mediated hepatic fibrosis and effects of antioxidant intervention in murine dietary steatohepatitis.
Topics: Animals; Antioxidants; Choline; Cytokines; Diet; Gene Expression; Glutathione; Hepatic Stellate Cells; Hepatitis; Liver; Liver Cirrhosis; Male; Matrix Metalloproteinases; Methionine; Mice; Mice, Inbred C57BL; Pyrrolidonecarboxylic Acid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiazolidines; Thiobarbituric Acid Reactive Substances; Time Factors; Tissue Inhibitor of Metalloproteinases; Vitamin E | 2009 |
High-performance liquid chromatography-tandem mass spectrometry for the determination of pidotimod in human plasma and its application to a pharmacokinetic study.
Topics: Chromatography, High Pressure Liquid; Humans; Immunologic Factors; Male; Pyrrolidonecarboxylic Acid; Tandem Mass Spectrometry; Thiazolidines | 2009 |
Pidotimod promotes functional maturation of dendritic cells and displays adjuvant properties at the nasal mucosa level.
Topics: Adjuvants, Immunologic; Animals; Antibody Formation; Antigens, CD; Cell Differentiation; Cell Proliferation; Cells, Cultured; Chemokine CCL2; Cytotoxicity, Immunologic; Dendritic Cells; Female; HLA-DR Antigens; Humans; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Nasal Mucosa; Ovalbumin; Peptide Fragments; Pyrrolidonecarboxylic Acid; Th1 Cells; Thiazolidines; Tumor Necrosis Factor-alpha | 2009 |
Glutathione modulation reverses the growth-promoting effect of growth factors, improving the 5-fluorouracil antitumour response in WiDr colon cancer cells.
Topics: Buthionine Sulfoximine; Cell Growth Processes; Cell Line, Tumor; Colonic Neoplasms; Epidermal Growth Factor; Fluorouracil; Glutathione; Hepatocyte Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Pyrrolidonecarboxylic Acid; Thiazolidines; Vascular Endothelial Growth Factor A | 2009 |
The protective effects of N-Acetl-cysteine, oxo-thiazolidine-carboxylate, acetaminophen and their combinations against sulfur mustard cytotoxicity on human skin fibroblast cell line (HF2FF).
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Catalase; Cell Line; Cell Survival; Chemical Warfare Agents; Cytoprotection; Drug Interactions; Fibroblasts; Free Radical Scavengers; Glutathione; Humans; Mustard Gas; Pyrrolidonecarboxylic Acid; Skin; Thiazolidines | 2009 |
Cytotoxicity of chlorhexidine on human osteoblastic cells is related to intracellular glutathione levels.
Topics: Anti-Infective Agents, Local; Antimetabolites; Buthionine Sulfoximine; Cell Line; Cell Proliferation; Chlorhexidine; Collagen; DNA; Dose-Response Relationship, Drug; Fluorescent Dyes; Glutathione; Humans; Osteoblasts; Prodrugs; Pyrrolidonecarboxylic Acid; Thiazolidines | 2010 |
Glutathione modulators reverse the pro-tumour effect of growth factors enhancing WiDr cell response to chemotherapeutic agents.
Topics: Antineoplastic Combined Chemotherapy Protocols; Buthionine Sulfoximine; Camptothecin; Cell Growth Processes; Cell Line, Tumor; Colonic Neoplasms; Drug Synergism; Epidermal Growth Factor; Fluorouracil; Glutathione; Hepatocyte Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Irinotecan; Organoplatinum Compounds; Oxaliplatin; Pyrrolidonecarboxylic Acid; Thiazolidines; Vascular Endothelial Growth Factor A | 2010 |
Cigarette smoke-induced changes to alveolar macrophage phenotype and function are improved by treatment with procysteine.
Topics: Animals; Apoptosis; Bronchoscopy; Flow Cytometry; Humans; Inflammation; Interleukin-12; Interleukin-1beta; Macrophages; Macrophages, Alveolar; Mice; Phagocytosis; Phenotype; Pulmonary Disease, Chronic Obstructive; Pyrrolidonecarboxylic Acid; Smoking; Thiazolidines; Tumor Necrosis Factor-alpha | 2011 |
Cytotoxicity of dentine bonding agents on human pulp cells is related to intracellular glutathione levels.
Topics: Acetone; Analysis of Variance; Bisphenol A-Glycidyl Methacrylate; Buthionine Sulfoximine; Cells, Cultured; Dental Materials; Dental Pulp; Dentin-Bonding Agents; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glutathione; Humans; Inhibitory Concentration 50; Polymethacrylic Acids; Pyrrolidonecarboxylic Acid; Resin Cements; Thiazolidines | 2010 |
Benzothiadiazole and l-2-oxothiazolidine-4-carboxylic acid reduce the severity of Sharka symptoms in pea leaves: effect on antioxidative metabolism at the subcellular level.
Topics: Antioxidants; Glutathione; Oxidation-Reduction; Oxidative Stress; Pisum sativum; Plant Diseases; Plant Leaves; Plum Pox Virus; Pyrrolidonecarboxylic Acid; Thiadiazoles; Thiazolidines | 2010 |
Protective effect of a cysteine prodrug and antioxidant, L-2-oxothiazolidine-4-carboxylate, against ethanol-induced gastric lesions in rats.
Topics: Animals; Anti-Ulcer Agents; Antioxidants; Cysteine; Disease Models, Animal; Ethanol; Female; Gastric Mucosa; Male; Prodrugs; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Stomach Ulcer; Thiazolidines | 2012 |
In vivo and in vitro assessment of the role of glutathione antioxidant system in anthracycline-induced cardiotoxicity.
Topics: Animals; Antibiotics, Antineoplastic; Antioxidants; Buthionine Sulfoximine; Cell Line; Daunorubicin; Dose-Response Relationship, Drug; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Heart; Heart Diseases; Hydrogen Peroxide; Male; Models, Animal; Oxidative Stress; Pyrrolidonecarboxylic Acid; Rabbits; Rats; Thiazolidines | 2011 |
Non-invasive monitoring of L-2-oxothiazolidine-4-carboxylate metabolism in the rat brain by in vivo 13C magnetic resonance spectroscopy.
Topics: Animals; Brain; Female; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oxidative Stress; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred F344; Thiazolidines | 2011 |
Self-double-emulsifying drug delivery system (SDEDDS): a new way for oral delivery of drugs with high solubility and low permeability.
Topics: Administration, Oral; Animals; Drug Delivery Systems; Drug Stability; Drug Storage; Emulsions; Male; Permeability; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Solubility; Surface-Active Agents; Thiazolidines | 2011 |
Water-in-oil-in-water double emulsions: an excellent delivery system for improving the oral bioavailability of pidotimod in rats.
Topics: Administration, Oral; Animals; Biological Availability; Drug Compounding; Drug Delivery Systems; Drug Stability; Emulsifying Agents; Emulsions; Male; Particle Size; Peptidomimetics; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Thiazolidines; Triglycerides; Viscosity; Water | 2011 |
Transport via SLC5A8 (SMCT1) is obligatory for 2-oxothiazolidine-4-carboxylate to enhance glutathione production in retinal pigment epithelial cells.
Topics: Animals; Apoptosis; Biological Transport; Cation Transport Proteins; Cell Survival; Cyclooxygenase Inhibitors; Drug Interactions; Glutathione; Humans; Hydrogen Peroxide; Ibuprofen; Kinetics; Mice; Mice, Mutant Strains; Monocarboxylic Acid Transporters; Oocytes; Oxidants; Oxidative Stress; Pyrrolidonecarboxylic Acid; Retinal Pigment Epithelium; Thiazolidines; Xenopus laevis | 2011 |
Chronic alcohol ingestion exacerbates lung epithelial barrier dysfunction in HIV-1 transgenic rats.
Topics: Alcoholism; Animals; Antioxidants; Central Nervous System Depressants; Comorbidity; Disease Models, Animal; Drug Evaluation, Preclinical; Epithelial Cells; Epithelium; Ethanol; Glutathione; HIV Envelope Protein gp120; HIV Infections; HIV-1; Lung; Lung Diseases; Male; Membrane Proteins; NF-E2-Related Factor 2; Occludin; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred F344; Rats, Transgenic; Thiazolidines; Tight Junctions; Time Factors | 2011 |
L-2-oxothiazolidine-4-carboxylate influence on age- and heat exposure-dependent redox changes in rat's blood plasma.
Topics: Animals; Glutathione; Hot Temperature; Ketones; Male; Oxidation-Reduction; Oxidative Stress; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Sulfhydryl Compounds; Thiazolidines | 2011 |
Plant growth stimulation in Prunus species plantlets by BTH or OTC treatments under in vitro conditions.
Topics: Ascorbate Peroxidases; Glutathione; Glutathione Peroxidase; Hydrogen Peroxide; Plant Proteins; Prunus; Pyrrolidonecarboxylic Acid; Superoxide Dismutase; Thiadiazoles; Thiazolidines | 2012 |
Anti-fibrotic effects of L-2-oxothiazolidine-4-carboxylic acid via modulation of nuclear factor erythroid 2-related factor 2 in rats.
Topics: Actins; Animals; Antifibrinolytic Agents; Collagen Type I; Gene Expression Regulation; Heme Oxygenase-1; Liver Cirrhosis, Experimental; Male; Malondialdehyde; NF-E2-Related Factor 2; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Thiazolidines; Transforming Growth Factor beta1; Up-Regulation | 2012 |
The detailed analysis of the changes of murine dendritic cells (DCs) induced by thymic peptide: pidotimod(PTD).
Topics: Adjuvants, Immunologic; Animals; B7-1 Antigen; B7-2 Antigen; Dendritic Cells; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Immunohistochemistry; Interleukin-12; Mice; Microscopy, Atomic Force; Microscopy, Electron, Transmission; Pyrrolidonecarboxylic Acid; Thiazolidines; Tumor Necrosis Factor-alpha | 2012 |
Chloroplast protection in plum pox virus-infected peach plants by L-2-oxo-4-thiazolidine-carboxylic acid treatments: effect in the proteome.
Topics: Antioxidants; Chlorophyll; Chloroplasts; Host-Pathogen Interactions; Oxidative Stress; Plant Diseases; Plum Pox Virus; Proteome; Prunus; Pyrrolidonecarboxylic Acid; Thiazolidines | 2013 |
L-2-Oxothiazolidine-4-carboxylic acid or α-lipoic acid attenuates airway remodeling: involvement of nuclear factor-κB (NF-κB), nuclear factor erythroid 2p45-related factor-2 (Nrf2), and hypoxia-inducible factor (HIF).
Topics: Airway Remodeling; Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Asthma; Basic Helix-Loop-Helix Transcription Factors; Drug Evaluation, Preclinical; Female; Hypoxia-Inducible Factor 1, alpha Subunit; Lung; MAP Kinase Signaling System; Mice, Inbred C57BL; Muscle, Smooth; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Pyrrolidonecarboxylic Acid; Thiazolidines; Thioctic Acid; Transforming Growth Factor beta1; Vascular Endothelial Growth Factor A | 2012 |
Synergistic effect of methionine encephalin (MENK) combined with pidotimod(PTD) on the maturation of murine dendritic cells (DCs).
Topics: Animals; Antigens, CD; Cell Differentiation; Cell Proliferation; Cells, Cultured; Dendritic Cells; Endocytosis; Enkephalin, Methionine; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Histocompatibility Antigens Class II; Immunologic Factors; Interleukin-12; Mice; Mice, Inbred C57BL; Microscopy; Pyrrolidonecarboxylic Acid; T-Lymphocytes; Thiazolidines; Tumor Necrosis Factor-alpha | 2013 |
The ameliorative effects of L-2-oxothiazolidine-4-carboxylate on acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Alanine Transaminase; Aldehydes; Analgesics, Non-Narcotic; Animals; Antioxidants; Apoptosis; Aspartate Aminotransferases; Caspase 3; Chemical and Drug Induced Liver Injury; DNA Fragmentation; Glutathione; Glutathione Peroxidase; Liver; Male; Malondialdehyde; Mice; Mice, Inbred BALB C; Necrosis; Oxidative Stress; Pyrrolidonecarboxylic Acid; Thiazolidines; Tyrosine | 2013 |
Modulation of airway epithelial cell functions by Pidotimod: NF-kB cytoplasmatic expression and its nuclear translocation are associated with an increased TLR-2 expression.
Topics: Biomarkers; Blotting, Western; Bronchi; Cell Line; Cell Nucleus; Enzyme-Linked Immunosorbent Assay; Epithelial Cells; Flow Cytometry; Gene Expression Regulation; Humans; Immunologic Factors; Intercellular Adhesion Molecule-1; Interleukin-8; MAP Kinase Signaling System; NF-kappa B; Phosphorylation; Pyrrolidonecarboxylic Acid; Thiazolidines; Toll-Like Receptor 2; Translocation, Genetic; Tumor Necrosis Factor-alpha; Up-Regulation | 2013 |
Protective effect of procysteine on Acinetobacter pneumonia in hyperoxic conditions.
Topics: Acinetobacter Infections; Administration, Intranasal; Animals; Antioxidants; Bacterial Load; Cytokines; Disease Models, Animal; Female; Histocytochemistry; Lung; Macrophages, Alveolar; Mice; Mice, Inbred BALB C; Phagocytosis; Pneumonia, Ventilator-Associated; Pyrrolidonecarboxylic Acid; Thiazolidines; Treatment Outcome | 2013 |
Preventive effect of pidotimod on reactivated toxoplasmosis in mice.
Topics: Animals; Cyclophosphamide; Cytokines; Female; Gene Expression Regulation; Immunologic Factors; Immunosuppressive Agents; Mice; Mice, Inbred BALB C; Parasitemia; Pyrrolidonecarboxylic Acid; Specific Pathogen-Free Organisms; Spleen; Thiazolidines; Toxoplasmosis, Animal | 2013 |
Evaluation of the adjuvant effect of pidotimod on the immune protection induced by UV-attenuated Toxoplasma gondii in mouse models.
Topics: Adjuvants, Immunologic; Animals; Antibodies, Protozoan; Antigens, Protozoan; Cytokines; Disease Models, Animal; Female; Humans; Immunoglobulin G; Injections, Intraperitoneal; Liver; Mice; Protozoan Proteins; Protozoan Vaccines; Pyrrolidonecarboxylic Acid; Species Specificity; Specific Pathogen-Free Organisms; Spleen; Thiazolidines; Toxoplasma; Toxoplasmosis; Ultraviolet Rays; Vaccination; Vaccines, Attenuated | 2013 |
Treatment with the cysteine precursor l-2-oxothiazolidine-4-carboxylate (OTC) implicates taurine deficiency in severity of dystropathology in mdx mice.
Topics: Acetylcysteine; Animals; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Muscular Dystrophy, Duchenne; Oxidative Stress; Pyrrolidonecarboxylic Acid; Taurine; Thiazolidines | 2013 |
Dietary antioxidants prevent alcohol-induced ciliary dysfunction.
Topics: Acetylcysteine; Adrenergic beta-2 Receptor Agonists; Animals; Antioxidants; Bronchoalveolar Lavage Fluid; Cilia; Ciliary Motility Disorders; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP-Dependent Protein Kinases; Dietary Supplements; Ethanol; Female; Mice; Procaterol; Pyrrolidonecarboxylic Acid; Reactive Nitrogen Species; Thiazolidines; Trachea | 2013 |
Pidotimod: the past and the present.
Topics: Acute Disease; Adaptive Immunity; Adjuvants, Immunologic; Animals; Child; Child, Preschool; Cohort Studies; Disease Models, Animal; Female; Forecasting; Humans; Immunity, Innate; Incidence; Male; Pyrrolidonecarboxylic Acid; Respiratory Tract Infections; Risk Factors; Secondary Prevention; Thiazolidines; Treatment Outcome | 2013 |
Sublingual surprise: a new variant of oral lichen planus.
Topics: Adjuvants, Immunologic; Administration, Oral; Adolescent; Adult; Autoimmunity; Biopsy; Chronic Disease; Humans; Immunologic Factors; Lichen Planus, Oral; Male; Pyrrolidonecarboxylic Acid; Thiazolidines; Treatment Outcome | 2014 |
L-2-oxothiazolidine-4-carboxylic acid attenuates oxidative stress and inflammation in retinal pigment epithelium.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; ATP-Binding Cassette Transporters; Cation Transport Proteins; Cell Line; Chemokine CCL2; Gene Expression Regulation; Humans; Inflammation; Interleukin-1beta; Interleukin-6; Mice; Mice, Inbred C57BL; Mice, Knockout; Monocarboxylic Acid Transporters; Oxidative Stress; Pyrrolidonecarboxylic Acid; Receptors, G-Protein-Coupled; Receptors, Nicotinic; Retinal Pigment Epithelium; RNA, Messenger; Thiazolidines; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 2014 |
The regulatory peptide pidotimod facilitates M2 macrophage polarization and its function.
Topics: Animals; Biomarkers; Cell Polarity; Macrophage Activation; Macrophages; Mice; Mice, Inbred C57BL; Peptides; Pyrrolidonecarboxylic Acid; Thiazolidines | 2014 |
Activation of MAPK and FoxO by manganese (Mn) in rat neonatal primary astrocyte cultures.
Topics: Active Transport, Cell Nucleus; Animals; Animals, Newborn; Astrocytes; Cell Nucleus; Cells, Cultured; Enzyme Activation; Enzyme Induction; Forkhead Box Protein O3; Forkhead Transcription Factors; Manganese; Mitogen-Activated Protein Kinases; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction; Superoxide Dismutase; Thiazolidines; Time Factors; Transcription Factors | 2014 |
[Pidotimod inhibits activation of latent Toxoplasma gondii infection induced by dexamethasone in mice].
Topics: Animals; Brain; Cytokines; Dexamethasone; DNA, Protozoan; Female; Mice; Mice, Inbred BALB C; Pyrrolidonecarboxylic Acid; T-Lymphocytes, Regulatory; Th1 Cells; Th2 Cells; Thiazolidines; Toxoplasma; Toxoplasmosis, Animal | 2013 |
Effect of procysteine on aging-associated changes in hepatic GSH and SMase: evidence for transcriptional regulation of smpd3.
Topics: Aging; Animals; Ceramides; Gene Expression Regulation, Enzymologic; Glutathione; Hep G2 Cells; Humans; Liver; Male; Mice; Pyrrolidonecarboxylic Acid; RNA, Messenger; Sphingomyelin Phosphodiesterase; Thiazolidines | 2014 |
Analysis of 2-oxothiazolidine-4-carboxylic acid by hydrophilic interaction liquid chromatography: application for ocular delivery using chitosan nanoparticles.
Topics: Animals; Cattle; Chitosan; Chromatography, Liquid; Cornea; Drug Delivery Systems; Hydrophobic and Hydrophilic Interactions; Nanoparticles; Pyrrolidonecarboxylic Acid; Thiazolidines | 2015 |
[Effectiveness of pidotimod in combination with bacterial lysates in the treatment of the pfapa (periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis) syndrome].
Topics: Adjuvants, Immunologic; Cell Extracts; Child; Child, Preschool; Drug Therapy, Combination; Female; Fever; Follow-Up Studies; Humans; Lymphadenitis; Male; Pharyngitis; Pyrrolidonecarboxylic Acid; Quality of Life; Stomatitis, Aphthous; Syndrome; Thiazolidines | 2015 |
Studies on Pidotimod Enantiomers With Chiralpak-IA: Crystal Structure, Thermodynamic Parameters and Molecular Docking.
Topics: Crystallography, X-Ray; Hydrogen Bonding; Molecular Docking Simulation; Molecular Structure; Pyrrolidonecarboxylic Acid; Stereoisomerism; Thermodynamics; Thiazolidines | 2015 |
[CELLS FORM AND THEIR SENSITIVITY TO LYTIC ACTIVITY OF NATURAL KILLER CELLS UNDER THE ANTIOXIDANT ACTION].
Topics: Acetylcysteine; Animals; Antibodies, Monoclonal; Antioxidants; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Transformed; Cell Shape; Coculture Techniques; Cytotoxicity, Immunologic; Enzyme Repression; Killer Cells, Natural; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Methionine Sulfoximine; Mice; NIH 3T3 Cells; Pyrrolidonecarboxylic Acid; Thiazolidines; Thioctic Acid | 2015 |
Increasing taurine intake and taurine synthesis improves skeletal muscle function in the mdx mouse model for Duchenne muscular dystrophy.
Topics: Animals; Disease Models, Animal; Female; Male; Mice; Mice, Inbred C57BL; Mice, Inbred mdx; Muscle Contraction; Muscle, Skeletal; Muscular Dystrophy, Duchenne; Pyrrolidonecarboxylic Acid; Taurine; Thiazolidines | 2016 |
A robust LC-MS/MS method for the determination of pidotimod in different biological matrixes and its application to in vivo and in vitro pharmacokinetic studies.
Topics: Animals; Caco-2 Cells; Chromatography, Liquid; Humans; Limit of Detection; Linear Models; Male; Pyrrolidonecarboxylic Acid; Rats, Sprague-Dawley; Reproducibility of Results; Tandem Mass Spectrometry; Thiazolidines | 2016 |
The dental monomer hydroxyethyl methacrylate (HEMA) counteracts lipopolysaccharide-induced IL-1β release-Possible role of glutathione.
Topics: Animals; Antioxidants; Cell Death; Cell Survival; Glutathione; Interleukin-1beta; Lipopolysaccharides; Methacrylates; Mice; Pyrrolidonecarboxylic Acid; RAW 264.7 Cells; Reactive Oxygen Species; Resins, Synthetic; RNA, Messenger; Thiazolidines; Tumor Necrosis Factor-alpha | 2017 |
Effects of pidotimod soluble powder and immune enhancement of Newcastle disease vaccine in chickens.
Topics: Adjuvants, Immunologic; Animals; Avian Proteins; Chickens; Interferon-gamma; Interleukin-2; Newcastle Disease; Newcastle disease virus; Pyrrolidonecarboxylic Acid; Thiazolidines; Viral Vaccines | 2017 |
Pidotimod exacerbates allergic pulmonary infection in an OVA mouse model of asthma.
Topics: Animals; Arginase; Asthma; Bronchoalveolar Lavage Fluid; Cell Differentiation; Disease Models, Animal; Down-Regulation; Eosinophils; Female; Hypersensitivity; Immunoglobulin E; Intercellular Signaling Peptides and Proteins; Lung; Metaplasia; Mice, Inbred C57BL; Mucus; Ovalbumin; Pyrrolidonecarboxylic Acid; Respiratory Tract Infections; Th2 Cells; Thiazolidines | 2017 |
Pharmacokinetics of pidotimod in broiler chickens by UHPLC-MS/MS after oral and intravenous administration.
Topics: Administration, Oral; Animals; Biological Availability; Chickens; Chromatography, High Pressure Liquid; Immunologic Factors; Injections, Intravenous; Linear Models; Pyrrolidonecarboxylic Acid; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Thiazolidines | 2018 |
N-acetylcysteine ethyl ester as GSH enhancer in human primary endothelial cells: A comparative study with other drugs.
Topics: Acetylcysteine; Cell Proliferation; Culture Media; Cysteine; Endothelial Cells; Ethyl Ethers; Glutathione; Human Umbilical Vein Endothelial Cells; Humans; Pyrrolidonecarboxylic Acid; Thiazolidines | 2018 |
L-2-oxothiazolidine-4-carboxylic acids slow down dialysate-induced senescence in human peritoneal mesothelial cells.
Topics: Cells, Cultured; Cellular Senescence; Dialysis Solutions; Glutathione; Humans; Inflammation; Inflammation Mediators; Peritoneal Dialysis; Peritoneum; Pyrrolidonecarboxylic Acid; Thiazolidines | 2018 |
Therapeutic Role of a Cysteine Precursor, OTC, in Ischemic Stroke Is Mediated by Improved Proteostasis in Mice.
Topics: Adaptor Proteins, Signal Transducing; Animals; Autophagy-Related Proteins; Brain Ischemia; Cells, Cultured; Cysteine; Ischemic Stroke; Male; Mice, Inbred C57BL; Neurons; Oxidative Stress; Proteostasis; Pyrrolidonecarboxylic Acid; Thiazolidines | 2020 |
The Synthetic Dipeptide Pidotimod Shows a Chemokine-Like Activity through CXC Chemokine Receptor 3 (CXCR3).
Topics: Antibodies, Monoclonal; Cell Adhesion; Cell Movement; Cells, Cultured; Chemotaxis; Dipeptides; Humans; Monocytes; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Isoforms; Proto-Oncogene Proteins c-akt; Pyrrolidonecarboxylic Acid; Receptors, CXCR3; RNA Interference; RNA, Small Interfering; Signal Transduction; T-Lymphocytes; Thiazolidines | 2019 |
Effects of Pidotimod on recurrent respiratory infections in children with Down syndrome: a retrospective Italian study.
Topics: Adjuvants, Immunologic; Child; Child, Preschool; Down Syndrome; Female; Humans; Immunoglobulin Isotypes; Italy; Male; Pyrrolidonecarboxylic Acid; Recurrence; Respiratory Tract Infections; Retrospective Studies; Thiazolidines | 2020 |
Pidotimod enhanced the anti-growth effect of cisplatin on lung cancer in mice via promoting anti-tumor immune response.
Topics: Adjuvants, Immunologic; Animals; Antineoplastic Agents; Carcinoma, Lewis Lung; Cell Proliferation; Cisplatin; Dendritic Cells; Drug Synergism; Immunity; Mice; Pyrrolidonecarboxylic Acid; Thiazolidines | 2020 |
A Model for SARS-CoV-2 Infection with Treatment.
Topics: Adjuvants, Immunologic; Angiotensin-Converting Enzyme 2; Basic Reproduction Number; Betacoronavirus; Computer Simulation; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Dose-Response Relationship, Drug; Host Microbial Interactions; Humans; Mathematical Concepts; Models, Biological; Mutation; Pandemics; Peptidyl-Dipeptidase A; Pneumonia, Viral; Pyrrolidonecarboxylic Acid; Receptors, Virus; SARS-CoV-2; Spike Glycoprotein, Coronavirus; T-Lymphocytes, Cytotoxic; Thiazolidines | 2020 |
2-Oxothiazolidine-4-carboxylic acid inhibits vascular calcification via induction of glutathione synthesis.
Topics: Alkaline Phosphatase; Apoptosis; Cell Differentiation; Cells, Cultured; Glutamate-Cysteine Ligase; Glutathione; Glutathione Synthase; Humans; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Osteoblasts; Phosphoric Diester Hydrolases; Prodrugs; Pyrophosphatases; Pyrrolidonecarboxylic Acid; Thiazolidines; Vascular Calcification | 2021 |
Pidotimod and Immunological Activation in Individuals Infected with HIV.
Topics: Adjuvants, Immunologic; Anti-Inflammatory Agents; Healthy Volunteers; HIV Infections; Humans; Immunity; Inflammation; Pyrrolidonecarboxylic Acid; Thiazolidines | 2021 |
Expert Opinion on Usage of Pidotimod in Adult Patients with Chronic Obstructive Pulmonary Disease: An Indian Perspective.
Topics: Adult; COVID-19; Expert Testimony; Humans; Pulmonary Disease, Chronic Obstructive; Pyrrolidonecarboxylic Acid; SARS-CoV-2; Thiazolidines | 2021 |
Prevention of recurrent respiratory infections : Inter-society Consensus.
Topics: Adenoidectomy; Adjuvants, Immunologic; Administration, Intranasal; Algorithms; Antibiotic Prophylaxis; Antioxidants; Child; Complementary Therapies; Humans; Hyaluronic Acid; Influenza Vaccines; Pneumococcal Vaccines; Prebiotics; Probiotics; Pyrrolidonecarboxylic Acid; Recurrence; Respiratory Tract Infections; Resveratrol; Thiazolidines; Tonsillectomy; Vitamins | 2021 |
Pidotimod increases inflammation in wounded zebrafish embryos.
Topics: Animals; Inflammation; Larva; Pyrrolidonecarboxylic Acid; Thiazolidines; Zebrafish | 2022 |