pyrrolidonecarboxylic acid and pidotimod

pyrrolidonecarboxylic acid has been researched along with pidotimod in 99 studies

Research

Studies (99)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	50 (50.51)	18.2507
2000's	7 (7.07)	29.6817
2010's	30 (30.30)	24.3611
2020's	12 (12.12)	2.80

Authors

Authors	Studies
Chisari, G; Condorelli, F; di Marco, R; di Mauro, M; Girardello, R; Meroni, PL; Nicoletti, F; Speciale, AM; Uslenghi, C	1
Coppi, G; D'Adamio, L; Migliorati, G; Nicoletti, I; Riccardi, C	1
Coppi, G; D'Adamio, F; Migliorati, G; Nicoletti, I; Pagliacci, C; Riccardi, C	1
Capsoni, F; Girardello, R; Minonzio, F; Ongari, AM; Zanussi, C	1
Forno, B; Girardello, R; Marinelli, L; Pollono, AM; Pugliese, A; Uslenghi, C	1
Coppi, G; Falcone, A; Manzardo, S	2
Auteri, A; Bova, G; Bruni, F; Di Renzo, M; Pasqui, AL; Saletti, M	1
Alfano, S; Biolchini, A; Careddu, P; Zavattini, G	1
Barchielli, M; Coppi, G	2
Annoni, G; Arosio, B; Cullurà, D; Gagliano, N; Santambrogio, D; Uslenghi, C	1
Maillard, F	1
Bocchiola, G; Magni, A; Signorelli, G	1
Anders, U; Bocchiola, G; Crimella, T; Orlandi, R; Stradi, R	1
Coppi, G; Manzardo, S	1
Migliorati, G; Nicoletti, I; Riccardi, C	1
Basilico, N; Cocuzza, C; Malabarba, MG; Mattina, R; Sala, G; Taramelli, D	1
Colangelo, D; Dianzani, C; Guidotto, S; Tonso, E; Viano, I	1
Barbera, N; Bernardini, R; Cantarella, G; Chiarenza, A; Iurato, MP; Lempereur, L; Scapagnini, G; Scapagnini, U	1
Coppi, G; Falcone, A; Ieva, G; Manzardo, S; Pinzetta, A	1
Amico-Roxas, M; Bertè, F; Bussi, R; Coppi, G; Gnemi, P; Harling, RJ; Mailland, F; Manzardo, S; Massey, JE; Spencer-Briggs, DJ	1
Adams, K; Allen, JA; Brooker, PC; Coppi, G; Henderson, L; Jones, E; Mailland, F; Proudlock, RJ	1
Coppi, G; Silingardi, S	1
Coppi, G; Mailland, F; Silingardi, S	1
Biffi, M; Coppi, G; Mailland, F; Silingardi, S; Spotti, D	1
Caravaggi, M; Crema, A; Crema, F; D'Angelo, L; De Ponti, F	1
Benetti, GP; Bombelli, G; Fugazza, L; Illeni, MT; La Vecchia, G; Montalto, F; Stramba Badiale, M; Uslenghi, C	1
Caramia, G; Carnelli, V; Cera, R; Clemente, E; Corsini, A; Mei, V; Solli, R; Venturoli, V	1
Careddu, P; Corsini, A; Mei, V; Venturoli, V	1
Caramia, G; Carnelli, V; Cera, R; Clemente, E; Corsini, A; Mei, V; Ruffini, E; Solli, R; Venturoli, V	1
Cirianni, C; Dolcetti, A; Fugazza, L; Moreo, G; Orlandi, O; Piacenza, G; Pozzi, E; Rampulla, C; Scarpazza, G	1
Bariffi, F; Bertoli, L; Bisetti, A; Cardani, A; Catena, E; Ciappi, G; Grassi, V; Rocco, V; Scarpazza, G; Vaccaro, L	1
Benetti, GP; Bombelli, G; Illeni, MT; Lavecchia, G; Passera, A; Uslenghi, C	1
Careddu, P	1
Calearo, C; Conticello, S; Passali, D	1
Ciaccia, A	1
De Campora, E; De Vita, C; Esposito, S; Galletti, C; Incutti, V; Mallardi, V; Motta, G; Motta, S; Pucci, V; Salonna, F	1
Burgio, GR; De Benedetti, F; Marseglia, GL; Masarone, M; Nespoli, L; Ottolenghi, A; Pagliano, L; Serra, U; Severi, F	1
Broccali, GP; Coppi, G; Dal Bo, L; Silingardi, S	1
Coppi, G; Delfino, D; Maggioni, A; Migliorati, G; Nicoletti, I; Riccardi, C	1
Campa, M; Girardello, R; Lupetti, A; Marelli, P; Senesi, S; Uslenghi, C	1
Caloro, D; Dammacco, F; Di Stefano, R; Ranieri, G; Vacca, A	1
Eftimiadi, C; Oddera, S; Rossi, GA; Sacco, O; Silvestri, M	1
Barcellini, W; Borghi, MO; Carbonelli, V; Del Papa, N; Fain, C; Gambini, D; La Rosa, L; Meroni, PL; Minonzio, F; Piona, A	1
Auteri, A; Bova, G; Bruni, F; Di Renzo, M; Gotti, G; Pasqui, AL; Saletti, M	1
Annoni, G; Arosio, B; Gagliano, N; Santambrogio, D	1
Auteri, A; Bova, G; Bruni, F; Chiarion, C; Di Renzo, M; Ferrì, P; Girardello, R; Pasqui, AL; Saletti, M	1
Guerra, B; Perino, A; Polatti, F; Scala, M	1
Di Mauro, M; Grillo, C; La Mantia, I; Mattina, T; Meroni, PL; Nicoletti, F; Xiang, M; Zaccone, P	1
Aivazis, V; Hatzimichail, A; Iuga-Donca, G; Papachristou, A; Valeri, R	1
Bossios, A; Gourgiotis, D; Papadopoulos, NG; Saxoni-Papageorgiou, P; Zamanis, P	1
Larcombe, J	1
Choung, SY; Du, XF; Jiang, CZ; Won, EK; Wu, CF	1
Choung, SY; Du Xiao, F; Jiang, CZ; Won, EK; Wu, CF	1
Li, F; Liu, W; Lu, S; Qin, F; Xiong, Z; Zhang, Y	1
Avolio, M; Becker, PD; Caruso, A; Fiorentini, S; Giagulli, C; Guzman, CA; Noerder, M	1
Li, F; Qin, F; Qin, T; Xiong, Z; Yang, S; Zhang, Y	1
Hu, Z; Qi, X; Wang, L; Zhang, J; Zhu, J	1
Qi, X; Wang, L; Zhu, J	1
Jiang, B; Lou, HG; Ruan, ZR	1
Hu, X; Hua, H; Li, W; Shan, F; Wan, N; Wang, B; Wang, L; Zhang, W	1
Meng, Y; Plotnikoff, NP; Shan, F; Wang, E; Wang, Q; Zhang, Z	1
Huang, JH; Huang, XH; Li, JC; Li, LJ; Shen, CL; Wang, K; Xie, XF; Zheng, QS	1
Carta, S; Rossi, GA; Silvestri, M	1
Cai, YH; Chen, H; Chen, ZW; Du, J; Fu, Y; Huo, XX; Lu, FL; Lun, ZR; Luo, QL; Shen, JL; Song, XR; Wang, H; Wang, L; Wang, Y; Xu, XC; Xu, YH; Zhang, AM	1
Huang, B; Huang, S; Kasper, LH; Li, YQ; Lu, F; Lun, ZR; Shen, J; Wang, Y; Zhao, Y; Zheng, H	1
Mameli, C; Zuccotti, GV	1
Chen, Q; Hu, T; Jin, X; Zeng, X; Zhao, X	1
Du, W; Fu, A; Fu, X; Hu, S; Ji, J; Li, W	1
Chen, H; Huo, XX; Kong, LT; Li, M; Shen, JL; Wang, WW; Zhang, Q	1
Artusio, L; Caimmi, S; De Amici, M; Licari, A; Marseglia, A; Marseglia, GL; Nigrisoli, S	1
Bedogni, G; Mameli, C; Pasinato, A; Picca, M; Pisanelli, S; Zuccotti, GV	1
Buongiorno, A; Pierossi, N	1
Biasin, M; Clerici, M; Esposito, S; Garziano, M; Marchisio, P; Principi, N; Rainone, V; Rossi, M; Senatore, L; Trabattoni, D	1
Chen, Y; Dou, X; Shen, W; Su, X; Wang, Y	1
Chen, H; Kang, D; Liang, Y; Rao, T; Shao, Y; Shen, B; Wang, G; Wang, Q; Xiao, J	1
Hayward, A; Lakhanpaul, M; Littlejohns, P; Manikam, L; Reed, K; Schilder, A; Venekamp, RP	1
Chen, J; He, Y; Huang, J; Li, M; Lv, Y; Wang, J; Wang, K; Xu, L; Yang, J; Zheng, Q	1
Blasi, F; Centanni, S; Clerici, M; Garziano, M; Mantero, M; Trabattoni, D	1
Cui, L; Dai, C; Hao, Z; Qiu, M; Qu, S; Wang, C; Zhang, R	1
Fu, AK; Fu, LQ; Hu, SL; Li, WF; Li, YL; Wang, YY; Wu, YP	1
Cui, L; Hao, Z; Qiu, M; Wang, C; Zhang, R; Zhao, L; Zhu, J	1
Cai, Y; Jia, YT; Niu, H; Wang, R	1
Baraldi, E; Bozzetto, S; Giordano, G; Montella, S; Pirillo, P; Poeta, M; Santamaria, F; Stocchero, M	1
Dong, X; Liu, C; Liu, X; Zhao, N; Zhu, C	1
Bugatti, A; Caccuri, F; Caruso, A; Corbellini, S; Giagulli, C; Marsico, S; Mazzuca, P; Roversi, S; Zani, A	1
Carsetti, R; Di Camillo, C; Marcellini, V; Mirante, N; Valentini, D; Villani, A	1
Canonica, GW; Feleszko, W; Kalyuzhin, O; Krenke, R; Rossi, GA; Van Gerven, L	1
Cui, J; Gao, J; Guo, W; Li, A; Wu, T; Zhou, H	1
Brindisi, G; Conte, MP; De Castro, G; Duse, M; Gori, A; Leonardi, L; Marazzato, M; Schiavi, L; Zicari, AM	1
Barone, P; Filosco, F; Finocchiaro, GG; Giugno, A; Leonardi, S; Manti, S; Papale, M; Parisi, GF	1
Leonardi, S; Manti, S; Papale, M; Parisi, GF	1
Al Basir, F; Chatterjee, AN	1
Huang, J; Li, L; Liu, H; Wen, X; Zhang, W; Zheng, Q	1
Jafrey, SZ; Karadkhele, A; Mahashur, A; Muchhala, S; Rathod, R; Suvarna, V; Vora, A; Waghray, P	1
Antonini, S; Becherucci, P; Biasci, P; Bortone, B; Bottero, S; Caldarelli, V; Cardinale, F; Chiappini, E; Ciarcià, M; Ciofi, D; Cutrera, R; D'Elios, S; de Martino, M; Del Giudice, MM; Di Mauro, G; Doria, M; Galli, L; Gattinara, GC; Indinnimeo, L; Lo Vecchio, A; Macrì, F; Marchisio, P; Marseglia, GL; Mattina, R; Miniello, VL; Morbin, G; Motisi, MA; Novelli, A; Palamara, AT; Panatta, ML; Pasinato, A; Peroni, D; Perruccio, K; Piacentini, G; Pifferi, M; Pignataro, L; Santamaria, F; Sitzia, E; Tersigni, C; Torretta, S; Trambusti, I; Trippella, G; Valentini, D; Valentini, S; Varricchio, A; Verga, MC; Vicini, C; Villani, A; Zecca, M	1
Ding, L; Feng, CG; Luo, K; Oehlers, SH	1
Deglurkar, R; Mathew, JL; Singh, M	1

Reviews

7 review(s) available for pyrrolidonecarboxylic acid and pidotimod

Article	Year
Urinary tract infection in children. Clinical evidence, 2005, Issue:13 Topics: Anti-Bacterial Agents; Child; Child, Preschool; Female; Humans; Infant; Male; Pyelonephritis; Pyrrolidonecarboxylic Acid; Secondary Prevention; Thiazoles; Thiazolidines; Urinary Tract Infections; Vesico-Ureteral Reflux	2005
Limited Evidence on the Management of Respiratory Tract Infections in Down's Syndrome: A Systematic Review. The Pediatric infectious disease journal, 2016, Volume: 35, Issue:10 Topics: Anti-Infective Agents; Bias; Clinical Trials as Topic; Down Syndrome; Humans; Palivizumab; Pyrrolidonecarboxylic Acid; Respiratory Tract Infections; Thiazolidines; Zinc	2016
Pidotimod, an immunostimulant in pediatric recurrent respiratory tract infections: A meta-analysis of randomized controlled trials. International immunopharmacology, 2019, Volume: 67 Topics: Adjuvants, Immunologic; Child; Child, Preschool; Humans; Immunity, Cellular; Immunity, Humoral; Immunoglobulins; Infant; Infant, Newborn; Pyrrolidonecarboxylic Acid; Randomized Controlled Trials as Topic; Recurrence; Respiratory Tract Infections; T-Lymphocyte Subsets; T-Lymphocytes; Thiazolidines	2019
Pidotimod: a review of its pharmacological features and clinical effectiveness in respiratory tract infections. Expert review of anti-infective therapy, 2019, Volume: 17, Issue:10 Topics: Acute Disease; Animals; Humans; Immunologic Factors; Pyrrolidonecarboxylic Acid; Respiratory Tract Infections; Risk Factors; Thiazolidines; Treatment Outcome	2019
Immunoactive preparations and regulatory responses in the respiratory tract: potential for clinical application in chronic inflammatory airway diseases. Expert review of respiratory medicine, 2020, Volume: 14, Issue:6 Topics: Asthma; Cell Extracts; Chronic Disease; Humans; Immunization; Immunologic Factors; Immunomodulation; Inflammation; Probiotics; Pulmonary Disease, Chronic Obstructive; Pyrrolidonecarboxylic Acid; Respiratory System; Respiratory Tract Diseases; Rhinitis; Sinusitis; Thiazolidines	2020
Pidotimod in allergic diseases. Minerva pediatrica, 2020, Volume: 72, Issue:5 Topics: Adaptive Immunity; Adjuvants, Immunologic; Adolescent; Asthma; Child; Child, Preschool; Chronic Urticaria; Dermatitis, Atopic; Desensitization, Immunologic; Food Hypersensitivity; Humans; Hypersensitivity; Immunity, Innate; Immunologic Factors; Pyrrolidonecarboxylic Acid; Rhinitis, Allergic; Thiazolidines	2020
Whether Immunostimulants Are Effective in Susceptible Children Suffering From Recurrent Respiratory Tract Infections: A Modeling Analysis Based on Literature Aggregate Data. Journal of clinical pharmacology, 2022, Volume: 62, Issue:2 Topics: Adjuvants, Immunologic; Cell Extracts; Child; Female; Humans; Male; Models, Biological; Pyrrolidonecarboxylic Acid; Respiratory Tract Infections; Thiazolidines	2022

Trials

32 trial(s) available for pyrrolidonecarboxylic acid and pidotimod

Article	Year
Pidotimod in the prophylaxis of recurrent acute tonsillitis in childhood. Advances in oto-rhino-laryngology, 1992, Volume: 47 Topics: Acute Disease; Adolescent; Child; Child, Preschool; Double-Blind Method; Female; Humans; Male; Pyrrolidonecarboxylic Acid; Recurrence; Thiazoles; Thiazolidines; Tonsillitis	1992
Pharmacokinetics and oral bioavailability of pidotimod in humans. Arzneimittel-Forschung, 1994, Volume: 44, Issue:12A Topics: Administration, Oral; Adolescent; Adult; Biological Availability; Cross-Over Studies; Double-Blind Method; Female; Half-Life; Humans; Immunologic Factors; Injections, Intramuscular; Male; Middle Aged; Protein Binding; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines	1994
Pharmacokinetics of pidotimod in elderly volunteers and in renal failure patients. Arzneimittel-Forschung, 1994, Volume: 44, Issue:12A Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Female; Half-Life; Humans; Immunologic Factors; Injections, Intravenous; Intestinal Absorption; Male; Middle Aged; Pyrrolidonecarboxylic Acid; Renal Insufficiency; Thiazoles; Thiazolidines; Urea	1994
Effect of food on the bioavailability of pidotimod in healthy volunteers. Arzneimittel-Forschung, 1994, Volume: 44, Issue:12A Topics: Adult; Biological Availability; Chromatography, High Pressure Liquid; Cross-Over Studies; Food-Drug Interactions; Humans; Immunologic Factors; Male; Pyrrolidonecarboxylic Acid; Spectrophotometry, Ultraviolet; Therapeutic Equivalency; Thiazoles; Thiazolidines	1994
Ex vivo evaluation of pidotimod activity on cell-mediated immunity. Arzneimittel-Forschung, 1994, Volume: 44, Issue:12A Topics: Adjuvants, Immunologic; Adult; Aged; Aged, 80 and over; CD3 Complex; Double-Blind Method; Female; Humans; Immunity, Cellular; Lymphocyte Count; Male; Middle Aged; Neoplasms; Phytohemagglutinins; Pyrrolidonecarboxylic Acid; Stimulation, Chemical; T-Lymphocytes; Thiazoles; Thiazolidines	1994
Efficacy and safety of pidotimod in the treatment of recurrent respiratory infections in children. Arzneimittel-Forschung, 1994, Volume: 44, Issue:12A Topics: Adjuvants, Immunologic; Anti-Bacterial Agents; Chemotaxis, Leukocyte; Child; Double-Blind Method; Female; Humans; Infant; Male; Phagocytosis; Pyrrolidonecarboxylic Acid; Recurrence; Respiratory Tract Infections; Thiazoles; Thiazolidines	1994
Pidotimod in the treatment of recurrent respiratory infections in paediatric patients. Arzneimittel-Forschung, 1994, Volume: 44, Issue:12A Topics: Bronchitis; Child; Child, Preschool; Double-Blind Method; Female; Humans; Immunologic Factors; Laryngitis; Lymphocyte Count; Male; Otitis; Pharyngitis; Pyrrolidonecarboxylic Acid; Recurrence; Respiratory Tract Infections; Rhinitis; Thiazoles; Thiazolidines; Tracheitis	1994
Therapeutic efficacy and safety of pidotimod in the treatment of urinary tract infections in children. Arzneimittel-Forschung, 1994, Volume: 44, Issue:12A Topics: Anti-Infective Agents, Urinary; Chemotaxis, Leukocyte; Child; Child, Preschool; Double-Blind Method; Female; Humans; Immunologic Factors; Male; Phagocytosis; Pyrrolidonecarboxylic Acid; Recurrence; Thiazoles; Thiazolidines; Urinary Tract Infections	1994
Pidotimod in the treatment of patients affected by bacterial exacerbations of chronic bronchitis. Arzneimittel-Forschung, 1994, Volume: 44, Issue:12A Topics: Adult; Aged; Bronchitis; Chronic Disease; Double-Blind Method; Female; Humans; Immunologic Factors; Male; Middle Aged; Pyrrolidonecarboxylic Acid; Recurrence; Respiratory Tract Infections; Skin Tests; Sputum; T-Lymphocytes, Helper-Inducer; T-Lymphocytes, Regulatory; Thiazoles; Thiazolidines	1994
Evaluation of the efficacy of pidotimod in the exacerbations in patients affected with chronic bronchitis. Arzneimittel-Forschung, 1994, Volume: 44, Issue:12A Topics: Adult; Aged; Aged, 80 and over; Bacterial Infections; Bronchitis; Chronic Disease; Double-Blind Method; Female; Follow-Up Studies; Humans; Immunologic Factors; Male; Middle Aged; Pyrrolidonecarboxylic Acid; Respiratory Function Tests; Thiazoles; Thiazolidines	1994
Ex vivo evaluation of pidotimod activity in patients with chronic obstructive pulmonary disease. Arzneimittel-Forschung, 1994, Volume: 44, Issue:12A Topics: Adjuvants, Immunologic; Adult; Aged; Aged, 80 and over; Double-Blind Method; Female; Follow-Up Studies; Granulocytes; Humans; Lung Diseases, Obstructive; Lymphocyte Activation; Lymphocytes; Macrophages; Male; Middle Aged; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines	1994
Role of immunoactivation with pidotimod in recurrent respiratory infections in childhood. Arzneimittel-Forschung, 1994, Volume: 44, Issue:12A Topics: Adjuvants, Immunologic; Adolescent; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Child; Child, Preschool; Double-Blind Method; Female; Humans; Male; Pyrrolidonecarboxylic Acid; Recurrence; Respiratory Tract Infections; Risk Factors; Thiazoles; Thiazolidines; Tonsillitis	1994
Pidotimod in the management of recurrent pharyngotonsillar infections in childhood. Arzneimittel-Forschung, 1994, Volume: 44, Issue:12A Topics: Adjuvants, Immunologic; Adolescent; Adult; Child; Double-Blind Method; Female; Humans; Male; Pharyngitis; Pyrrolidonecarboxylic Acid; Recurrence; Thiazoles; Thiazolidines; Tonsillitis	1994
Pidotimod activity against chronic bronchitis exacerbations. Arzneimittel-Forschung, 1994, Volume: 44, Issue:12A Topics: Adjuvants, Immunologic; Aged; Bronchitis; Chronic Disease; Double-Blind Method; Female; Humans; Male; Middle Aged; Patient Dropouts; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines	1994
Immunoactivity of pidotimod against episodes of recurrent tonsillitis in childhood. Arzneimittel-Forschung, 1994, Volume: 44, Issue:12A Topics: Adjuvants, Immunologic; Adolescent; Anti-Bacterial Agents; Anti-Inflammatory Agents; Child; Child, Preschool; Double-Blind Method; Female; Humans; Male; Pyrrolidonecarboxylic Acid; Recurrence; Thiazoles; Thiazolidines; Tonsillitis	1994
Immunoactivation by pidotimod in children with recurrent respiratory infections. Arzneimittel-Forschung, 1994, Volume: 44, Issue:12A Topics: Adjuvants, Immunologic; Adolescent; Child; Child, Preschool; Double-Blind Method; Female; Humans; Interleukin-2; Leukocytes; Male; Phytohemagglutinins; Pyrrolidonecarboxylic Acid; Receptors, Interleukin-2; Recurrence; Respiratory Tract Infections; Thiazoles; Thiazolidines	1994
[Pidotimod, a new biological response modifier, is able to partially prevent immune response changes related to surgical stress]. Drugs under experimental and clinical research, 1993, Volume: 19 Suppl Topics: Adjuvants, Immunologic; Adolescent; Adult; Anesthesia, General; Antibody Formation; Complement C3; Complement C4; Double-Blind Method; Female; Humans; Immune System; Immunologic Deficiency Syndromes; Interleukin-2; Lymphocyte Activation; Lymphocyte Subsets; Male; Middle Aged; Neutrophils; Phagocytosis; Pyrrolidonecarboxylic Acid; Respiratory Burst; Stress, Physiological; Surgical Procedures, Operative; Thiazoles; Thiazolidines	1993
Pidotimod in the management of vulvar papillomatosis: double-blind clinical trial versus placebo. American journal of therapeutics, 1998, Volume: 5, Issue:3 Topics: Administration, Oral; Adolescent; Adult; Biopsy; Colposcopy; Condylomata Acuminata; Double-Blind Method; Female; Humans; Immunologic Factors; Middle Aged; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Treatment Outcome; Vulvar Diseases	1998
Prophylaxis with the novel immunomodulator pidotimod reduces the frequency and severity of upper respiratory tract infections in children with Down's syndrome. Journal of chemotherapy (Florence, Italy), 1999, Volume: 11, Issue:2 Topics: Adolescent; Child; Child, Preschool; Down Syndrome; Female; Humans; Immunologic Factors; Incidence; Male; Pyrrolidonecarboxylic Acid; Recurrence; Respiratory Tract Infections; Severity of Illness Index; Thiazoles; Thiazolidines	1999
Clinical evaluation and changes of the respiratory epithelium function after administration of Pidotimod in Greek children with recurrent respiratory tract infections. Minerva pediatrica, 2002, Volume: 54, Issue:4 Topics: Adjuvants, Immunologic; Child; Child, Preschool; Female; Greece; Humans; Male; Mucociliary Clearance; Prospective Studies; Pyrrolidonecarboxylic Acid; Respiratory Mucosa; Respiratory Tract Infections; Thiazoles; Thiazolidines; Treatment Outcome	2002
Hydrophilic interaction liquid chromatography-tandem mass spectrometry for the determination of adefovir in human plasma and its application to a pharmacokinetic study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2010, Aug-01, Volume: 878, Issue:23 Topics: Adenine; Administration, Oral; Antiviral Agents; Chromatography, Liquid; Drug Stability; Humans; Limit of Detection; Male; Organophosphonates; Pyrrolidonecarboxylic Acid; Quality Control; Reference Standards; Reproducibility of Results; Tandem Mass Spectrometry; Thiazolidines; Time Factors	2010
Quantitative determination of pidotimod in human plasma by liquid chromatography tandem mass spectrometry: application to a bioequivalence study. Arzneimittel-Forschung, 2012, Volume: 62, Issue:2 Topics: Adjuvants, Immunologic; Area Under Curve; Asian People; Chromatography, High Pressure Liquid; Cross-Over Studies; Double-Blind Method; Half-Life; Humans; Indicators and Reagents; Pyrrolidonecarboxylic Acid; Quality Control; Reference Standards; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Therapeutic Equivalency; Thiazolidines	2012
Bioequivalence evaluation of two formulations of pidotimod using a limited sampling strategy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2013, Volume: 67, Issue:6 Topics: Administration, Oral; Adolescent; Adult; Area Under Curve; Chemistry, Pharmaceutical; Cross-Over Studies; Healthy Volunteers; Humans; Male; Models, Theoretical; Pyrrolidonecarboxylic Acid; Therapeutic Equivalency; Thiazolidines; Young Adult	2013
Pidotimod may prevent recurrent respiratory infections in children. Minerva pediatrica, 2014, Volume: 66, Issue:5 Topics: Adjuvants, Immunologic; Child; Child, Preschool; Double-Blind Method; Female; Follow-Up Studies; Humans; Male; Pyrrolidonecarboxylic Acid; Respiratory Tract Infections; Thiazolidines; Treatment Outcome	2014
Pidotimod for the prevention of acute respiratory infections in healthy children entering into daycare: A double blind randomized placebo-controlled study. Pharmacological research, 2015, Volume: 97 Topics: Acute Disease; Adjuvants, Immunologic; Child Day Care Centers; Double-Blind Method; Female; Humans; Immunization; Incidence; Infant; Male; Pyrrolidonecarboxylic Acid; Respiratory Tract Infections; Risk Reduction Behavior; Thiazolidines; Treatment Outcome	2015
Immunomodulatory activity of pidotimod administered with standard antibiotic therapy in children hospitalized for community-acquired pneumonia. Journal of translational medicine, 2015, Sep-03, Volume: 13 Topics: Adjuvants, Immunologic; Adolescent; Anti-Bacterial Agents; Child; Child, Preschool; Community-Acquired Infections; Dendritic Cells; Female; Hospitalization; Humans; Immunity, Innate; Inflammation; Interleukin-12; Male; Peptides; Pneumonia; Polysaccharides, Bacterial; Pyrrolidonecarboxylic Acid; Respiratory Tract Infections; RNA, Messenger; Thiazolidines; Tumor Necrosis Factor-alpha	2015
Advantage of population pharmacokinetic method for evaluating the bioequivalence and accuracy of parameter estimation of pidotimod. International journal of clinical pharmacology and therapeutics, 2016, Volume: 54, Issue:9 Topics: Adolescent; Adult; Area Under Curve; Asian People; Cross-Over Studies; Humans; Immunologic Factors; Male; Models, Biological; Nonlinear Dynamics; Pyrrolidonecarboxylic Acid; Therapeutic Equivalency; Thiazolidines; Young Adult	2016
Immunomodulatory effects of pidotimod in adults with community-acquired pneumonia undergoing standard antibiotic therapy. Pulmonary pharmacology & therapeutics, 2017, Volume: 44 Topics: Anti-Bacterial Agents; Community-Acquired Infections; Female; Hospitalization; Humans; Immunity, Innate; Immunologic Factors; Levofloxacin; Male; Middle Aged; Pneumonia; Prospective Studies; Pyrrolidonecarboxylic Acid; Thiazolidines; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha	2017
Effects of pidotimod and bifidobacteria mixture on clinical symptoms and urinary metabolomic profile of children with recurrent respiratory infections: a randomized placebo-controlled trial. Pulmonary pharmacology & therapeutics, 2019, Volume: 58 Topics: Adjuvants, Immunologic; Bifidobacterium; Child; Child, Preschool; Female; Humans; Placebos; Pregnancy; Probiotics; Prospective Studies; Pyrrolidonecarboxylic Acid; Respiratory Tract Infections; Thiazolidines; Trial of Labor	2019
Efficacy of Pidotimod use in treating allergic rhinitis in a pediatric population. Italian journal of pediatrics, 2020, Jul-07, Volume: 46, Issue:1 Topics: Adenoids; Age Factors; Child; Female; Humans; Hypertrophy; Immunologic Factors; Italy; Male; Nasal Obstruction; Pyrrolidonecarboxylic Acid; Rhinitis, Allergic; Thiazolidines; Treatment Outcome	2020
Proposal for a new therapeutic high dosage of Pidotimod in children with periodic fever, aphthous stomatitis, pharyngitis, adenitis (PFAPA) syndrome: a randomized controlled study. Italian journal of pediatrics, 2020, Jul-25, Volume: 46, Issue:1 Topics: Betamethasone; Child; Child, Preschool; Cross-Over Studies; Familial Mediterranean Fever; Female; Glucocorticoids; Humans; Immunologic Factors; Lymphadenitis; Male; Pharyngitis; Prospective Studies; Pyrrolidonecarboxylic Acid; Stomatitis, Aphthous; Syndrome; Thiazolidines; Treatment Outcome	2020
Efficacy and Safety of Pidotimod in Persistent Asthma: A Randomized Triple-Blinded Placebo-Controlled Trial. Indian pediatrics, 2022, Mar-15, Volume: 59, Issue:3 Topics: Administration, Inhalation; Adrenal Cortex Hormones; Asthma; Budesonide; Child; Double-Blind Method; Humans; Metered Dose Inhalers; Pyrrolidonecarboxylic Acid; Thiazolidines	2022

Other Studies

60 other study(ies) available for pyrrolidonecarboxylic acid and pidotimod

Article	Year
Increased rate of survival in Streptococcus pneumoniae-infected rats treated with the new immunomodulator Pidotimod. Scandinavian journal of infectious diseases, 1992, Volume: 24, Issue:6 Topics: Adjuvants, Immunologic; Animals; Male; Pneumonia, Pneumococcal; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Thiazoles; Thiazolidines	1992
Pidotimod stimulates natural killer cell activity and inhibits thymocyte cell death. Immunopharmacology and immunotoxicology, 1992, Volume: 14, Issue:4 Topics: Adjuvants, Immunologic; Animals; Apoptosis; Calcium; Cellular Senescence; Cytotoxicity, Immunologic; Killer Cells, Natural; Mice; Mice, Inbred C3H; Pyrrolidonecarboxylic Acid; Spleen; T-Lymphocytes; Thiazoles; Thiazolidines	1992
Immunopharmacology of Pidotimod: effect on natural killer cell activity and thymocyte cell death. Pharmacological research, 1992, Volume: 26 Suppl 2 Topics: Animals; Apoptosis; Cell Death; Dexamethasone; Killer Cells, Natural; Mice; Mice, Inbred C3H; Pyrrolidonecarboxylic Acid; T-Lymphocytes; Thiazoles; Thiazolidines	1992
Evaluation of the kinetics of the immunomodulating activity of Pidotimod on human neutrophils. Pharmacological research, 1992, Volume: 26 Suppl 2 Topics: Adjuvants, Immunologic; Adult; Humans; Neutrophils; Phagocytosis; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines	1992
Ex vivo evaluation of Pidotimod effect on immune response. Pharmacological research, 1992, Volume: 26 Suppl 2 Topics: Adjuvants, Immunologic; Adult; Chemotaxis, Leukocyte; Humans; Immunity, Cellular; Lymphocyte Activation; Male; Phytohemagglutinins; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines	1992
Activity of the new immunostimulant PGT/1A against experimental bacterial infections. Pharmacological research, 1992, Volume: 26 Suppl 2 Topics: Adjuvants, Immunologic; Animals; Bacterial Infections; Male; Mice; Mice, Inbred ICR; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines	1992
Effect of Pidotimod, a new immunostimulating agent, on some aspects of immune response. In vitro study. Pharmacological research, 1992, Volume: 26 Suppl 2 Topics: Adjuvants, Immunologic; Complement System Proteins; Humans; Immunity, Cellular; Lymphocyte Activation; Lymphocytes; Neutrophils; Phagocytosis; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines	1992
Simple high-performance liquid chromatographic method for the determination of PGT/1A, a new immunostimulating drug, in biological fluids. Journal of chromatography, 1991, Feb-15, Volume: 563, Issue:2 Topics: Acetonitriles; Adjuvants, Immunologic; Adult; Chromatography, High Pressure Liquid; Humans; Injections, Intravenous; Male; Phosphates; Potassium; Potassium Compounds; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines	1991
Activity of PGT/1A, a new immunostimulating drug, on macrophages and lymphocytes in immunodepressed mice. Acta physiologica Hungarica, 1990, Volume: 75 Suppl Topics: Adjuvants, Immunologic; Animals; Bacterial Infections; Immunosuppression Therapy; Lymphocytes; Macrophages; Mice; Pyrrolidinones; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines	1990
Gene expression for interleukin-2 and tumor necrosis factor-alpha in the spleen of old rats under physiological condition and during septic shock. Possible pharmacological modulation. Arzneimittel-Forschung, 1994, Volume: 44, Issue:12A Topics: Aging; Animals; Blotting, Northern; Gene Expression Regulation; Immunologic Factors; Interleukin-2; Male; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; RNA; Shock, Septic; Spleen; Thiazoles; Thiazolidines; Tumor Necrosis Factor-alpha	1994
Pidotimod. A new biological response modifier. Introduction. Arzneimittel-Forschung, 1994, Volume: 44, Issue:12A Topics: Adjuvants, Immunologic; Animals; Bacterial Infections; Humans; Immunologic Factors; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines	1994
Synthesis and preliminary pharmacological evaluation of pidotimod, its enantiomer, diastereomers and carboxamido derivatives. Arzneimittel-Forschung, 1994, Volume: 44, Issue:12A Topics: Adjuvants, Immunologic; Animals; Bacterial Infections; Immunologic Factors; Macrophages; Male; Mice; Mice, Inbred Strains; Prednisolone; Pyrrolidonecarboxylic Acid; Stereoisomerism; Structure-Activity Relationship; Superoxides; Thiazoles; Thiazolidines	1994
Analytical and chemical profile of pidotimod. Arzneimittel-Forschung, 1994, Volume: 44, Issue:12A Topics: Calorimetry, Differential Scanning; Chemical Phenomena; Chemistry, Physical; Chromatography, High Pressure Liquid; Crystallography, X-Ray; Immunologic Factors; Isomerism; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Weight; Pyrrolidonecarboxylic Acid; Solubility; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Thermogravimetry; Thiazoles; Thiazolidines	1994
Experimental immunological screening tests on pidotimod. Arzneimittel-Forschung, 1994, Volume: 44, Issue:12A Topics: Adjuvants, Immunologic; Animals; Antibody Formation; B-Lymphocytes; Chemotaxis, Leukocyte; Dinitrochlorobenzene; Graft vs Host Reaction; Hypersensitivity, Delayed; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mononuclear Phagocyte System; Organ Size; Pyrrolidonecarboxylic Acid; Sheep; Spleen; T-Lymphocytes; Thiazoles; Thiazolidines; Thymus Gland	1994
Protective effects of pidotimod against experimental bacterial infections in mice. Arzneimittel-Forschung, 1994, Volume: 44, Issue:12A Topics: Adjuvants, Immunologic; Animals; Anti-Bacterial Agents; Cyclophosphamide; Enterobacteriaceae Infections; Immunosuppression Therapy; Lactams; Male; Mice; Mice, Inbred Strains; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines	1994
Immunomodulating activity of pidotimod. Arzneimittel-Forschung, 1994, Volume: 44, Issue:12A Topics: Adjuvants, Immunologic; Animals; Apoptosis; Calcimycin; Cell Division; DNA; Female; Flow Cytometry; Killer Cells, Natural; Male; Mice; Mice, Inbred C3H; Mitogens; Protein-Tyrosine Kinases; Pyrrolidonecarboxylic Acid; Spleen; T-Lymphocytes; Thiazoles; Thiazolidines; Tissue Plasminogen Activator; Tumor Cells, Cultured	1994
Effects of pidotimod on macrophage functions in methylprednisolone-treated mice. Arzneimittel-Forschung, 1994, Volume: 44, Issue:12A Topics: Adjuvants, Immunologic; Animals; Aspergillus fumigatus; Cell Adhesion; Cell Division; Cytokines; Female; Interferon-gamma; Lipopolysaccharides; Macrophages; Methylprednisolone; Mice; Mice, Inbred Strains; Nitric Oxide; Pyrrolidonecarboxylic Acid; Spores, Fungal; Thiazoles; Thiazolidines; Tumor Necrosis Factor-alpha	1994
In vivo antiviral effects of pidotimod. Arzneimittel-Forschung, 1994, Volume: 44, Issue:12A Topics: Adjuvants, Immunologic; Animals; Antiviral Agents; Cardiovirus Infections; Herpes Simplex; Influenza A virus; Male; Mengovirus; Mice; Orthomyxoviridae Infections; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Virus Diseases	1994
Effects of pidotimod on the immune and the neuroendocrine system in the aging rat. Arzneimittel-Forschung, 1994, Volume: 44, Issue:12A Topics: Adjuvants, Immunologic; Adrenocorticotropic Hormone; Aging; Animals; Cytokines; Immune System; Immunologic Factors; Interleukin-1; Lymphocytes; Male; Mitogens; Neurosecretory Systems; Pituitary-Adrenal System; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Spleen; Thiazoles; Thiazolidines	1994
General pharmacology of pidotimod and testing for drug interactions. Arzneimittel-Forschung, 1994, Volume: 44, Issue:12A Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Autonomic Nervous System; Behavior, Animal; Central Nervous System; Diuresis; Dogs; Drug Interactions; Guinea Pigs; Hemodynamics; Immunologic Factors; In Vitro Techniques; Male; Mice; Muscle, Smooth; Pyrrolidonecarboxylic Acid; Rabbits; Rats; Respiration; Thiazoles; Thiazolidines	1994
Toxicological evaluation of pidotimod. Arzneimittel-Forschung, 1994, Volume: 44, Issue:12A Topics: Animals; Dogs; Female; Fertility; Lethal Dose 50; Male; Mice; Mice, Inbred Strains; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Teratogens; Thiazoles; Thiazolidines	1994
Genotoxicity testing of pidotimod in vitro and in vivo. Arzneimittel-Forschung, 1994, Volume: 44, Issue:12A Topics: Animals; Bone Marrow; Bone Marrow Cells; Cells, Cultured; CHO Cells; Chromosome Aberrations; Cricetinae; DNA Repair; Erythrocytes; HeLa Cells; Humans; In Vitro Techniques; Mice; Micronucleus Tests; Mutagenicity Tests; Mutagens; Pyrrolidonecarboxylic Acid; Rats; Salmonella typhimurium; Thiazoles; Thiazolidines	1994
Pharmacokinetics of pidotimod in rats and dogs. Arzneimittel-Forschung, 1994, Volume: 44, Issue:12A Topics: Administration, Oral; Animals; Biological Availability; Chromatography, High Pressure Liquid; Dogs; Half-Life; Immunologic Factors; Injections, Intramuscular; Injections, Intravenous; Male; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Thiazoles; Thiazolidines; Tissue Distribution	1994
A new HPLC method for pidotimod plasma levels determination. Bollettino chimico farmaceutico, 1993, Volume: 132, Issue:4 Topics: Adult; Chromatography, High Pressure Liquid; Humans; Immunologic Factors; Male; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines	1993
[Pidotimod causes apoptotic cell death and inhibits the proliferative activity of YAC-1 tumor cells in vitro]. Drugs under experimental and clinical research, 1993, Volume: 19 Suppl Topics: Adjuvants, Immunologic; Animals; Antineoplastic Agents; Apoptosis; Biological Transport; Calcium; Cell Division; DNA, Neoplasm; Drug Screening Assays, Antitumor; G2 Phase; Lymphoma, T-Cell; Mice; Mice, Inbred A; Mitosis; Neoplasm Proteins; Neoplastic Stem Cells; Phosphoproteins; Phosphorylation; Protein Processing, Post-Translational; Pyrrolidonecarboxylic Acid; T-Lymphocytes; Thiazoles; Thiazolidines; Tumor Cells, Cultured	1993
[Potentiation of the resistance to viral and bacterial infections after pidotimod administration in mice]. Drugs under experimental and clinical research, 1993, Volume: 19 Suppl Topics: Adjuvants, Immunologic; Animals; Bacterial Infections; Coxsackievirus Infections; Enterovirus B, Human; Female; Immunity, Innate; Influenza A virus; Mice; Mice, Inbred BALB C; Orthomyxoviridae Infections; Pyrrolidonecarboxylic Acid; Streptococcal Infections; Streptococcus agalactiae; Thiazoles; Thiazolidines; Virus Diseases	1993
[Stimulation of B-cell immunity in the nude mice by pidotimod: immunohistochemical stucy of various lymphoid organs]. Drugs under experimental and clinical research, 1993, Volume: 19 Suppl Topics: Adjuvants, Immunologic; Animals; Antibody Formation; B-Lymphocytes; Cell Differentiation; Immunoenzyme Techniques; Immunoglobulins; Immunologic Deficiency Syndromes; Intestinal Mucosa; Lung; Lymph Nodes; Lymphocyte Activation; Lymphoid Tissue; Mice; Mice, Nude; Pyrrolidonecarboxylic Acid; Spleen; Thiazoles; Thiazolidines	1993
[Effect of pidotimod on phagocytosis and intracellular killing of Staphylococcus aureus by human circulating polymorphonuclear neutrophils and alveolar macrophages]. Drugs under experimental and clinical research, 1993, Volume: 19 Suppl Topics: Adjuvants, Immunologic; Adolescent; Adult; Coloring Agents; Cytotoxicity, Immunologic; Female; Fluorescent Dyes; Humans; Hydrogen Peroxide; Indoles; Macrophage Activation; Macrophages, Alveolar; Male; Microscopy, Fluorescence; Neutrophils; Phagocytosis; Pyrrolidonecarboxylic Acid; Respiratory Burst; Staphylococcus aureus; Thiazoles; Thiazolidines	1993
[Effect of pidotimod on the function of the human immune system: in vitro and ex vivo study]. Drugs under experimental and clinical research, 1993, Volume: 19 Suppl Topics: Adjuvants, Immunologic; Administration, Oral; Adult; Aged; Aged, 80 and over; Aging; Antibody Formation; Chemotaxis, Leukocyte; Humans; Immune System; Interferon-gamma; Interleukin-1; Interleukin-2; Interleukin-6; Lymphocyte Activation; Lymphocyte Subsets; Mitogens; Muromonab-CD3; Neutrophils; Phagocytosis; Phytohemagglutinins; Pyrrolidonecarboxylic Acid; Tetradecanoylphorbol Acetate; Thiazoles; Thiazolidines	1993
[Levels of interleukin-2 )IL-2 and tumor necrosis factor alpha (TNF-alpha) mRNA in aged rat spleen under physiological conditions and in septic shock: possible role of pidotimod in gene expression modulation]. Drugs under experimental and clinical research, 1993, Volume: 19 Suppl Topics: Adjuvants, Immunologic; Aging; Animals; Escherichia coli Infections; Gene Expression Regulation; Interleukin-2; Male; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; RNA, Messenger; Shock, Septic; Spleen; Stimulation, Chemical; Thiazoles; Thiazolidines; Tumor Necrosis Factor-alpha	1993
The in vitro effect of Pidotimod on some immune functions in cancer patients. Immunopharmacology and immunotoxicology, 1997, Volume: 19, Issue:1 Topics: Adjuvants, Immunologic; Female; Humans; Immunity, Cellular; Immunologic Factors; Interleukin-2; Leukocytes, Mononuclear; Lymphocyte Activation; Male; Neoplasms; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines	1997
Immune modulator pidotimod decreases the in vitro expression of CD30 in peripheral blood mononuclear cells of atopic asthmatic and normal children. The Journal of asthma : official journal of the Association for the Care of Asthma, 2004, Volume: 41, Issue:3 Topics: Asthma; Child; Child, Preschool; Cytokines; Down-Regulation; Female; Humans; Hypersensitivity; Immunologic Factors; Ki-1 Antigen; Leukocytes, Mononuclear; Male; Pyrrolidonecarboxylic Acid; T-Lymphocytes, Helper-Inducer; Thiazoles; Thiazolidines	2004
Synergistic immunostimulating activity of pidotimod and red ginseng acidic polysaccharide against cyclophosphamide-induced immunosuppression. Archives of pharmacal research, 2008, Volume: 31, Issue:9 Topics: Adjuvants, Immunologic; Animals; Body Weight; C-Reactive Protein; Cell Proliferation; Cell Survival; Cyclophosphamide; Drug Synergism; Immunosuppressive Agents; Killer Cells, Natural; Macrophages, Peritoneal; Male; Mice; Mice, Inbred BALB C; Nitric Oxide; Organ Size; Panax; Polysaccharides; Pyrrolidonecarboxylic Acid; Spleen; Tetrazolium Salts; Thiazoles; Thiazolidines	2008
Synergistic immunostimulatory effect of pidotimod and red ginseng acidic polysaccharide on humoral immunity of immunosuppressed mice. Die Pharmazie, 2008, Volume: 63, Issue:12 Topics: Adjuvants, Immunologic; Alanine Transaminase; Animals; Antibody Formation; Antineoplastic Agents, Alkylating; Cell Count; Cyclophosphamide; Drug Synergism; Erythrocytes; Female; Immunoglobulin E; Immunoglobulin G; Immunosuppression Therapy; Kidney Function Tests; Leukocytes; Liver Function Tests; Lymph Nodes; Mice; Mice, Inbred BALB C; Panax; Plant Extracts; Polysaccharides; Pyrrolidonecarboxylic Acid; Spleen; Thiazolidines; Thymus Gland	2008
High-performance liquid chromatography-tandem mass spectrometry for the determination of pidotimod in human plasma and its application to a pharmacokinetic study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2009, Aug-15, Volume: 877, Issue:24 Topics: Chromatography, High Pressure Liquid; Humans; Immunologic Factors; Male; Pyrrolidonecarboxylic Acid; Tandem Mass Spectrometry; Thiazolidines	2009
Pidotimod promotes functional maturation of dendritic cells and displays adjuvant properties at the nasal mucosa level. International immunopharmacology, 2009, Volume: 9, Issue:12 Topics: Adjuvants, Immunologic; Animals; Antibody Formation; Antigens, CD; Cell Differentiation; Cell Proliferation; Cells, Cultured; Chemokine CCL2; Cytotoxicity, Immunologic; Dendritic Cells; Female; HLA-DR Antigens; Humans; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Nasal Mucosa; Ovalbumin; Peptide Fragments; Pyrrolidonecarboxylic Acid; Th1 Cells; Thiazolidines; Tumor Necrosis Factor-alpha	2009
Self-double-emulsifying drug delivery system (SDEDDS): a new way for oral delivery of drugs with high solubility and low permeability. International journal of pharmaceutics, 2011, May-16, Volume: 409, Issue:1-2 Topics: Administration, Oral; Animals; Drug Delivery Systems; Drug Stability; Drug Storage; Emulsions; Male; Permeability; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Solubility; Surface-Active Agents; Thiazolidines	2011
Water-in-oil-in-water double emulsions: an excellent delivery system for improving the oral bioavailability of pidotimod in rats. Journal of pharmaceutical sciences, 2011, Volume: 100, Issue:6 Topics: Administration, Oral; Animals; Biological Availability; Drug Compounding; Drug Delivery Systems; Drug Stability; Emulsifying Agents; Emulsions; Male; Particle Size; Peptidomimetics; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Thiazolidines; Triglycerides; Viscosity; Water	2011
The detailed analysis of the changes of murine dendritic cells (DCs) induced by thymic peptide: pidotimod(PTD). Human vaccines & immunotherapeutics, 2012, Volume: 8, Issue:9 Topics: Adjuvants, Immunologic; Animals; B7-1 Antigen; B7-2 Antigen; Dendritic Cells; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Immunohistochemistry; Interleukin-12; Mice; Microscopy, Atomic Force; Microscopy, Electron, Transmission; Pyrrolidonecarboxylic Acid; Thiazolidines; Tumor Necrosis Factor-alpha	2012
Synergistic effect of methionine encephalin (MENK) combined with pidotimod(PTD) on the maturation of murine dendritic cells (DCs). Human vaccines & immunotherapeutics, 2013, Volume: 9, Issue:4 Topics: Animals; Antigens, CD; Cell Differentiation; Cell Proliferation; Cells, Cultured; Dendritic Cells; Endocytosis; Enkephalin, Methionine; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Histocompatibility Antigens Class II; Immunologic Factors; Interleukin-12; Mice; Mice, Inbred C57BL; Microscopy; Pyrrolidonecarboxylic Acid; T-Lymphocytes; Thiazolidines; Tumor Necrosis Factor-alpha	2013
Modulation of airway epithelial cell functions by Pidotimod: NF-kB cytoplasmatic expression and its nuclear translocation are associated with an increased TLR-2 expression. Italian journal of pediatrics, 2013, May-10, Volume: 39 Topics: Biomarkers; Blotting, Western; Bronchi; Cell Line; Cell Nucleus; Enzyme-Linked Immunosorbent Assay; Epithelial Cells; Flow Cytometry; Gene Expression Regulation; Humans; Immunologic Factors; Intercellular Adhesion Molecule-1; Interleukin-8; MAP Kinase Signaling System; NF-kappa B; Phosphorylation; Pyrrolidonecarboxylic Acid; Thiazolidines; Toll-Like Receptor 2; Translocation, Genetic; Tumor Necrosis Factor-alpha; Up-Regulation	2013
Preventive effect of pidotimod on reactivated toxoplasmosis in mice. Parasitology research, 2013, Volume: 112, Issue:8 Topics: Animals; Cyclophosphamide; Cytokines; Female; Gene Expression Regulation; Immunologic Factors; Immunosuppressive Agents; Mice; Mice, Inbred BALB C; Parasitemia; Pyrrolidonecarboxylic Acid; Specific Pathogen-Free Organisms; Spleen; Thiazolidines; Toxoplasmosis, Animal	2013
Evaluation of the adjuvant effect of pidotimod on the immune protection induced by UV-attenuated Toxoplasma gondii in mouse models. Parasitology research, 2013, Volume: 112, Issue:9 Topics: Adjuvants, Immunologic; Animals; Antibodies, Protozoan; Antigens, Protozoan; Cytokines; Disease Models, Animal; Female; Humans; Immunoglobulin G; Injections, Intraperitoneal; Liver; Mice; Protozoan Proteins; Protozoan Vaccines; Pyrrolidonecarboxylic Acid; Species Specificity; Specific Pathogen-Free Organisms; Spleen; Thiazolidines; Toxoplasma; Toxoplasmosis; Ultraviolet Rays; Vaccination; Vaccines, Attenuated	2013
Pidotimod: the past and the present. Italian journal of pediatrics, 2013, Dec-06, Volume: 39 Topics: Acute Disease; Adaptive Immunity; Adjuvants, Immunologic; Animals; Child; Child, Preschool; Cohort Studies; Disease Models, Animal; Female; Forecasting; Humans; Immunity, Innate; Incidence; Male; Pyrrolidonecarboxylic Acid; Respiratory Tract Infections; Risk Factors; Secondary Prevention; Thiazolidines; Treatment Outcome	2013
Sublingual surprise: a new variant of oral lichen planus. The American journal of medicine, 2014, Volume: 127, Issue:1 Topics: Adjuvants, Immunologic; Administration, Oral; Adolescent; Adult; Autoimmunity; Biopsy; Chronic Disease; Humans; Immunologic Factors; Lichen Planus, Oral; Male; Pyrrolidonecarboxylic Acid; Thiazolidines; Treatment Outcome	2014
The regulatory peptide pidotimod facilitates M2 macrophage polarization and its function. Amino acids, 2014, Volume: 46, Issue:5 Topics: Animals; Biomarkers; Cell Polarity; Macrophage Activation; Macrophages; Mice; Mice, Inbred C57BL; Peptides; Pyrrolidonecarboxylic Acid; Thiazolidines	2014
[Pidotimod inhibits activation of latent Toxoplasma gondii infection induced by dexamethasone in mice]. Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases, 2013, Volume: 31, Issue:5 Topics: Animals; Brain; Cytokines; Dexamethasone; DNA, Protozoan; Female; Mice; Mice, Inbred BALB C; Pyrrolidonecarboxylic Acid; T-Lymphocytes, Regulatory; Th1 Cells; Th2 Cells; Thiazolidines; Toxoplasma; Toxoplasmosis, Animal	2013
[Effectiveness of pidotimod in combination with bacterial lysates in the treatment of the pfapa (periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis) syndrome]. Minerva pediatrica, 2015, Volume: 67, Issue:3 Topics: Adjuvants, Immunologic; Cell Extracts; Child; Child, Preschool; Drug Therapy, Combination; Female; Fever; Follow-Up Studies; Humans; Lymphadenitis; Male; Pharyngitis; Pyrrolidonecarboxylic Acid; Quality of Life; Stomatitis, Aphthous; Syndrome; Thiazolidines	2015
Studies on Pidotimod Enantiomers With Chiralpak-IA: Crystal Structure, Thermodynamic Parameters and Molecular Docking. Chirality, 2015, Volume: 27, Issue:11 Topics: Crystallography, X-Ray; Hydrogen Bonding; Molecular Docking Simulation; Molecular Structure; Pyrrolidonecarboxylic Acid; Stereoisomerism; Thermodynamics; Thiazolidines	2015
A robust LC-MS/MS method for the determination of pidotimod in different biological matrixes and its application to in vivo and in vitro pharmacokinetic studies. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2016, Jun-15, Volume: 1023-1024 Topics: Animals; Caco-2 Cells; Chromatography, Liquid; Humans; Limit of Detection; Linear Models; Male; Pyrrolidonecarboxylic Acid; Rats, Sprague-Dawley; Reproducibility of Results; Tandem Mass Spectrometry; Thiazolidines	2016
Effects of pidotimod soluble powder and immune enhancement of Newcastle disease vaccine in chickens. Immunology letters, 2017, Volume: 187 Topics: Adjuvants, Immunologic; Animals; Avian Proteins; Chickens; Interferon-gamma; Interleukin-2; Newcastle Disease; Newcastle disease virus; Pyrrolidonecarboxylic Acid; Thiazolidines; Viral Vaccines	2017
Pidotimod exacerbates allergic pulmonary infection in an OVA mouse model of asthma. Molecular medicine reports, 2017, Volume: 16, Issue:4 Topics: Animals; Arginase; Asthma; Bronchoalveolar Lavage Fluid; Cell Differentiation; Disease Models, Animal; Down-Regulation; Eosinophils; Female; Hypersensitivity; Immunoglobulin E; Intercellular Signaling Peptides and Proteins; Lung; Metaplasia; Mice, Inbred C57BL; Mucus; Ovalbumin; Pyrrolidonecarboxylic Acid; Respiratory Tract Infections; Th2 Cells; Thiazolidines	2017
Pharmacokinetics of pidotimod in broiler chickens by UHPLC-MS/MS after oral and intravenous administration. Biomedical chromatography : BMC, 2018, Volume: 32, Issue:3 Topics: Administration, Oral; Animals; Biological Availability; Chickens; Chromatography, High Pressure Liquid; Immunologic Factors; Injections, Intravenous; Linear Models; Pyrrolidonecarboxylic Acid; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Thiazolidines	2018
The Synthetic Dipeptide Pidotimod Shows a Chemokine-Like Activity through CXC Chemokine Receptor 3 (CXCR3). International journal of molecular sciences, 2019, Oct-24, Volume: 20, Issue:21 Topics: Antibodies, Monoclonal; Cell Adhesion; Cell Movement; Cells, Cultured; Chemotaxis; Dipeptides; Humans; Monocytes; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Isoforms; Proto-Oncogene Proteins c-akt; Pyrrolidonecarboxylic Acid; Receptors, CXCR3; RNA Interference; RNA, Small Interfering; Signal Transduction; T-Lymphocytes; Thiazolidines	2019
Effects of Pidotimod on recurrent respiratory infections in children with Down syndrome: a retrospective Italian study. Italian journal of pediatrics, 2020, Mar-13, Volume: 46, Issue:1 Topics: Adjuvants, Immunologic; Child; Child, Preschool; Down Syndrome; Female; Humans; Immunoglobulin Isotypes; Italy; Male; Pyrrolidonecarboxylic Acid; Recurrence; Respiratory Tract Infections; Retrospective Studies; Thiazolidines	2020
Pidotimod enhanced the anti-growth effect of cisplatin on lung cancer in mice via promoting anti-tumor immune response. Biochemical and biophysical research communications, 2020, 08-06, Volume: 528, Issue:4 Topics: Adjuvants, Immunologic; Animals; Antineoplastic Agents; Carcinoma, Lewis Lung; Cell Proliferation; Cisplatin; Dendritic Cells; Drug Synergism; Immunity; Mice; Pyrrolidonecarboxylic Acid; Thiazolidines	2020
A Model for SARS-CoV-2 Infection with Treatment. Computational and mathematical methods in medicine, 2020, Volume: 2020 Topics: Adjuvants, Immunologic; Angiotensin-Converting Enzyme 2; Basic Reproduction Number; Betacoronavirus; Computer Simulation; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Dose-Response Relationship, Drug; Host Microbial Interactions; Humans; Mathematical Concepts; Models, Biological; Mutation; Pandemics; Peptidyl-Dipeptidase A; Pneumonia, Viral; Pyrrolidonecarboxylic Acid; Receptors, Virus; SARS-CoV-2; Spike Glycoprotein, Coronavirus; T-Lymphocytes, Cytotoxic; Thiazolidines	2020
Expert Opinion on Usage of Pidotimod in Adult Patients with Chronic Obstructive Pulmonary Disease: An Indian Perspective. The Journal of the Association of Physicians of India, 2021, Volume: 69, Issue:9 Topics: Adult; COVID-19; Expert Testimony; Humans; Pulmonary Disease, Chronic Obstructive; Pyrrolidonecarboxylic Acid; SARS-CoV-2; Thiazolidines	2021
Prevention of recurrent respiratory infections : Inter-society Consensus. Italian journal of pediatrics, 2021, Oct-25, Volume: 47, Issue:1 Topics: Adenoidectomy; Adjuvants, Immunologic; Administration, Intranasal; Algorithms; Antibiotic Prophylaxis; Antioxidants; Child; Complementary Therapies; Humans; Hyaluronic Acid; Influenza Vaccines; Pneumococcal Vaccines; Prebiotics; Probiotics; Pyrrolidonecarboxylic Acid; Recurrence; Respiratory Tract Infections; Resveratrol; Thiazolidines; Tonsillectomy; Vitamins	2021
Pidotimod increases inflammation in wounded zebrafish embryos. Fish & shellfish immunology, 2022, Volume: 120 Topics: Animals; Inflammation; Larva; Pyrrolidonecarboxylic Acid; Thiazolidines; Zebrafish	2022