pyrrolidine has been researched along with proline in 27 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (11.11) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 16 (59.26) | 29.6817 |
| 2010's | 8 (29.63) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Brandsch, M; Gebauer, S; Laug, L; Schäfer, S; Thondorf, I; Voigt, V; Zebisch, K | 1 |
| Hitoshi, T; Ijima, S; Iwamura, H; Kadota, T; Matsuda, A; Miyata, T; Nagata, J; Naka, M; Okano, Y; Takahama, K | 1 |
| Hughes, NE; Madalengoitia, JS; Mamai, A; Wurthmann, A | 1 |
| Dickerson, TJ; Janda, KD | 1 |
| SCHLUTZ, GO | 1 |
| KLOSA, J | 1 |
| Mans, DM; Pearson, WH | 1 |
| Chang, K; Ding, XB; Guan, Y; Liu, XY; Long, XP; Peng, YX; Wang, XC | 1 |
| Edwards, PJ; Hardré, R; Taylor, CM | 1 |
| Ganesh, KN; Kumar, VA | 1 |
| Guo, H; Li, H; Lou, B; Mei, Y; Wang, J; Wang, W; Xie, D; Xu, D | 1 |
| Helaja, J; Koivisto, J; Koskinen, AM; Kumpulainen, ET; Mansikkamäki, H; Rissanen, K | 1 |
| Carper, E; Etzkorn, FA; Poutsma, JC; Poutsma, JL; Schroeder, OE; Wind, JJ | 1 |
| Burstyn, JN; Clark, RW; Pinkert, JC | 1 |
| Fülep, GH; Hoesl, CE; Höfner, G; Wanner, KT | 1 |
| Gribkov, DV; Pastine, SJ; Sames, D; Schnürch, M | 1 |
| Albertshofer, K; Barbas, CF; Cheong, PH; Garcia-Delgado, N; Houk, KN; Imai, M; Mifsud, M; Mitsumori, S; Tanaka, F; Utsumi, N; Zhang, H | 1 |
| García-García, P; Halder, R; Ladépêche, A; List, B | 1 |
| Beale, PJ; Diakos, CI; Fenton, RR; Hambley, TW; Zhang, M | 1 |
| Fang, D; Guo, L; Lian, Y; Zhao, G; Zhao, X; Zhou, J; Zhuang, W | 1 |
| De Mey, E; Dejaegher, B; Drabik-Markiewicz, G; Impens, S; Kowalska, T; Paelinck, H; Vander Heyden, Y | 1 |
| Alemán, C; Cativiela, C; Jiménez, AI; Revilla-López, G; Torras, J; Warren, JG | 1 |
| Ai, HB; Lu, G; Luo, RS; Weng, J | 1 |
| Höfner, GC; Pabel, J; Wanner, KT; Zhao, X | 1 |
| Saito, S; Schulte, A; Situ, X; Wünsch, B | 1 |
| Aher, RD; Kumar, BS; Sudalai, A | 1 |
| Aguilar, H; Asatryan, A; Asselah, T; Baumgarten, A; Conway, B; Dore, GJ; Foster, GR; Grebely, J; Gschwantler, M; Hu, Y; Jackson, D; Mensa, FJ; Sherman, KE; Tomasiewicz, K; Wang, S | 1 |
1 trial(s) available for pyrrolidine and proline
| Article | Year |
|---|---|
Glecaprevir/pibrentasvir in patients with chronic HCV and recent drug use: An integrated analysis of 7 phase III studies.
Topics: Adult; Aged; Aged, 80 and over; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Therapy, Combination; Drug Users; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Ribavirin; Sofosbuvir; Sulfonamides; Sustained Virologic Response; Treatment Outcome; Young Adult | 2019 |
26 other study(ies) available for pyrrolidine and proline
| Article | Year |
|---|---|
Three-dimensional quantitative structure-activity relationship analyses of substrates of the human proton-coupled amino acid transporter 1 (hPAT1).
Topics: Amino Acid Transport Systems; Caco-2 Cells; Endocytosis; Humans; Kinetics; Models, Chemical; Models, Molecular; Molecular Conformation; Quantitative Structure-Activity Relationship; Substrate Specificity; Symporters | 2011 |
Imino acid and related alicyclic amine levels in biological fluids.
Topics: Amines; Animals; Body Fluids; Female; Gas Chromatography-Mass Spectrometry; Humans; Imino Acids; Male; Pipecolic Acids; Piperidines; Proline; Pyrrolidines; Rabbits; Rats; Rats, Inbred Strains | 1985 |
Synthesis of conformationally constrained arginine and ornithine analogues based on the 3-substituted pyrrolidine framework.
Topics: Arginine; Molecular Conformation; Molecular Mimicry; Ornithine; Peptides; Proline; Pyrrolidines | 2001 |
Aqueous aldol catalysis by a nicotine metabolite.
Topics: Acetone; Benzaldehydes; Catalysis; Kinetics; Nicotine; Proline; Pyrrolidines; Substrate Specificity; Water | 2002 |
[Conversion of glutamic acid in animal through L-pyrrolidine carboxylic acid into proline].
Topics: Animals; Carboxylic Acids; Glutamates; Glutamic Acid; Proline; Pyrrolidines | 1953 |
[Synthesis of some pyrrolidine-2,5-dicarboxylic acid alkamine esters. 10. On synthesis of spasmolytic substances].
Topics: Amino Acids; Dicarboxylic Acids; Drug Combinations; Esters; Parasympatholytics; Proline; Pyrrolidines; Sorbitol | 1955 |
Total synthesis of (+)-cocaine via desymmetrization of a meso-dialdehyde.
Topics: Aldehydes; Catalysis; Cocaine; Cyclization; Molecular Structure; Proline; Pyrrolidines; Stereoisomerism | 2004 |
Design of temperature sensitive imprinted polymer hydrogels based on multiple-point hydrogen bonding.
Topics: Adsorption; Hydrogels; Hydrogen Bonding; Hydrogen-Ion Concentration; Proline; Pyrrolidines; Pyrrolidinones; Substrate Specificity; Temperature | 2004 |
The impact of pyrrolidine hydroxylation on the conformation of proline-containing peptides.
Topics: Dipeptides; Hydroxylation; Magnetic Resonance Spectroscopy; Molecular Conformation; Molecular Structure; Proline; Pyrrolidines; Thermodynamics | 2005 |
Conformationally constrained PNA analogues: structural evolution toward DNA/RNA binding selectivity.
Topics: Amino Acid Sequence; Directed Molecular Evolution; DNA; Molecular Sequence Data; Nucleic Acid Conformation; Peptide Nucleic Acids; Piperidines; Proline; Pyrrolidines; RNA; Substrate Specificity | 2005 |
Direct, facile aldehyde and ketone alpha-selenenylation reactions promoted by L-prolinamide and pyrrolidine sulfonamide organocatalysts.
Topics: Aldehydes; Catalysis; Ketones; Models, Chemical; Proline; Pyrrolidines; Selenium; Stereoisomerism; Sulfonamides | 2005 |
Locked conformations for proline pyrrolidine ring: synthesis and conformational analysis of cis- and trans-4-tert-butylprolines.
Topics: Crystallography, X-Ray; Molecular Conformation; Proline; Pyrrolidines; Stereoisomerism | 2005 |
Theoretical and experimental investigation of the energetics of cis-trans proline isomerization in peptide models.
Topics: Acetamides; Algorithms; Binding Sites; Catalysis; Hydrogen Bonding; Isomerism; Models, Chemical; Nitrogen; Oxygen; Peptides; Peptidylprolyl Isomerase; Proline; Protons; Pyrrolidines; Serine; Thermodynamics; Threonine | 2006 |
Modeling proline ligation in the heme-dependent CO sensor, CooA, using small-molecule analogs.
Topics: Bacterial Proteins; Carbon Monoxide; Computational Biology; Crystallography, X-Ray; Heme; Hemeproteins; Histidine; Imidazoles; Iron; Ligands; Models, Molecular; Molecular Structure; Proline; Pyrrolidines; Trans-Activators | 2006 |
New highly potent GABA uptake inhibitors selective for GAT-1 and GAT-3 derived from (R)- and (S)-proline and homologous pyrrolidine-2-alkanoic acids.
Topics: Alkanes; Alkylation; Carboxylic Acids; GABA Plasma Membrane Transport Proteins; GABA Uptake Inhibitors; gamma-Aminobutyric Acid; Methylation; Molecular Structure; Proline; Pyrrolidines; Saponins; Stereoisomerism; Structure-Activity Relationship | 2006 |
Ruthenium catalyzed decarbonylative arylation at sp3 carbon centers in pyrrolidine and piperidine heterocycles.
Topics: Boronic Acids; Carbon; Catalysis; Esters; Hydrocarbons, Aromatic; Hydroxyproline; Ketones; Models, Chemical; Piperidines; Proline; Pyrrolidines; Ruthenium; Stereoisomerism | 2007 |
Catalysis of 3-pyrrolidinecarboxylic acid and related pyrrolidine derivatives in enantioselective anti-Mannich-type reactions: importance of the 3-acid group on pyrrolidine for stereocontrol.
Topics: Aldehydes; Catalysis; Imines; Ketones; Molecular Structure; Proline; Pyrrolidines; Stereoisomerism | 2008 |
Catalytic asymmetric Michael reactions of acetaldehyde.
Topics: Acetaldehyde; Catalysis; Molecular Structure; Proline; Pyrrolidines; Stereoisomerism; Styrenes | 2008 |
Synthesis, characterisation and in vitro cytotoxicity studies of a series of chiral platinum(II) complexes based on the 2-aminomethylpyrrolidine ligand: X-ray crystal structure of [PtCl2(R-dimepyrr)] (R-dimepyrr=N-dimethyl-2(R)-aminomethylpyrrolidine).
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Crystallography, X-Ray; Humans; Ligands; Models, Molecular; Organometallic Compounds; Platinum; Proline; Pyrrolidines; Stereoisomerism | 2009 |
Synthesis and biological evaluation of 4-fluoroproline and 4-fluoropyrrolidine-2-acetic acid derivatives as new GABA uptake inhibitors.
Topics: Acetates; Animals; Cell Line; GABA Uptake Inhibitors; gamma-Aminobutyric Acid; Inhibitory Concentration 50; Mice; Proline; Pyrrolidines; Structure-Activity Relationship | 2009 |
Evaluation of the influence of proline, hydroxyproline or pyrrolidine in the presence of sodium nitrite on N-nitrosamine formation when heating cured meat.
Topics: Carcinogens; Chromatography, Gas; Dimethylnitrosamine; Hydroxyproline; Limit of Detection; Meat; N-Nitrosopyrrolidine; Nitrosamines; Proline; Pyrrolidines; Sodium Nitrite; Temperature | 2010 |
Effects of ring contraction on the conformational preferences of α-substituted proline analogs.
Topics: Amides; Azetidinecarboxylic Acid; Models, Molecular; Molecular Conformation; Peptides; Proline; Pyrrolidines; Quantum Theory | 2012 |
Asymmetric Michael reaction of aldehydes with β-nitroalkenes catalyzed by pyrrolidine-camphor derived organocatalysts bearing hydrogen-bond donors.
Topics: Aldehydes; Alkenes; Camphor; Catalysis; Hydrogen Bonding; Models, Chemical; Proline; Pyrrolidines | 2012 |
Synthesis and biological evaluation of 4-hydroxy-4-(4-methoxyphenyl)-substituted proline and pyrrolidin-2-ylacetic acid derivatives as GABA uptake inhibitors.
Topics: Drug Evaluation, Preclinical; GABA Plasma Membrane Transport Proteins; GABA Uptake Inhibitors; Proline; Protein Binding; Pyrrolidines; Stereoisomerism; Structure-Activity Relationship | 2013 |
Bromolactamization: key step in the stereoselective synthesis of enantiomerically pure, cis-configured perhydropyrroloquinoxalines.
Topics: Chemistry Techniques, Synthetic; Glutamates; Lactams; Lactams, Macrocyclic; Magnetic Resonance Spectroscopy; Molecular Structure; Proline; Pyrrolidines; Quinoxalines; Stereoisomerism | 2014 |
Proline-catalyzed sequential syn-Mannich and [4 + 1]-annulation cascade reactions to form densely functionalized pyrrolidines.
Topics: Aldehydes; Catalysis; Molecular Structure; Proline; Pyrrolidines; Stereoisomerism | 2015 |