Page last updated: 2024-08-23

pyrrolidine and proline

pyrrolidine has been researched along with proline in 27 studies

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19903 (11.11)18.7374
1990's0 (0.00)18.2507
2000's16 (59.26)29.6817
2010's8 (29.63)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Brandsch, M; Gebauer, S; Laug, L; Schäfer, S; Thondorf, I; Voigt, V; Zebisch, K1
Hitoshi, T; Ijima, S; Iwamura, H; Kadota, T; Matsuda, A; Miyata, T; Nagata, J; Naka, M; Okano, Y; Takahama, K1
Hughes, NE; Madalengoitia, JS; Mamai, A; Wurthmann, A1
Dickerson, TJ; Janda, KD1
SCHLUTZ, GO1
KLOSA, J1
Mans, DM; Pearson, WH1
Chang, K; Ding, XB; Guan, Y; Liu, XY; Long, XP; Peng, YX; Wang, XC1
Edwards, PJ; Hardré, R; Taylor, CM1
Ganesh, KN; Kumar, VA1
Guo, H; Li, H; Lou, B; Mei, Y; Wang, J; Wang, W; Xie, D; Xu, D1
Helaja, J; Koivisto, J; Koskinen, AM; Kumpulainen, ET; Mansikkamäki, H; Rissanen, K1
Carper, E; Etzkorn, FA; Poutsma, JC; Poutsma, JL; Schroeder, OE; Wind, JJ1
Burstyn, JN; Clark, RW; Pinkert, JC1
Fülep, GH; Hoesl, CE; Höfner, G; Wanner, KT1
Gribkov, DV; Pastine, SJ; Sames, D; Schnürch, M1
Albertshofer, K; Barbas, CF; Cheong, PH; Garcia-Delgado, N; Houk, KN; Imai, M; Mifsud, M; Mitsumori, S; Tanaka, F; Utsumi, N; Zhang, H1
García-García, P; Halder, R; Ladépêche, A; List, B1
Beale, PJ; Diakos, CI; Fenton, RR; Hambley, TW; Zhang, M1
Fang, D; Guo, L; Lian, Y; Zhao, G; Zhao, X; Zhou, J; Zhuang, W1
De Mey, E; Dejaegher, B; Drabik-Markiewicz, G; Impens, S; Kowalska, T; Paelinck, H; Vander Heyden, Y1
Alemán, C; Cativiela, C; Jiménez, AI; Revilla-López, G; Torras, J; Warren, JG1
Ai, HB; Lu, G; Luo, RS; Weng, J1
Höfner, GC; Pabel, J; Wanner, KT; Zhao, X1
Saito, S; Schulte, A; Situ, X; Wünsch, B1
Aher, RD; Kumar, BS; Sudalai, A1
Aguilar, H; Asatryan, A; Asselah, T; Baumgarten, A; Conway, B; Dore, GJ; Foster, GR; Grebely, J; Gschwantler, M; Hu, Y; Jackson, D; Mensa, FJ; Sherman, KE; Tomasiewicz, K; Wang, S1

Trials

1 trial(s) available for pyrrolidine and proline

ArticleYear
Glecaprevir/pibrentasvir in patients with chronic HCV and recent drug use: An integrated analysis of 7 phase III studies.
    Drug and alcohol dependence, 2019, 01-01, Volume: 194

    Topics: Adult; Aged; Aged, 80 and over; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Cyclopropanes; Drug Therapy, Combination; Drug Users; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Liver Cirrhosis; Male; Middle Aged; Proline; Pyrrolidines; Quinoxalines; Ribavirin; Sofosbuvir; Sulfonamides; Sustained Virologic Response; Treatment Outcome; Young Adult

2019

Other Studies

26 other study(ies) available for pyrrolidine and proline

ArticleYear
Three-dimensional quantitative structure-activity relationship analyses of substrates of the human proton-coupled amino acid transporter 1 (hPAT1).
    Bioorganic & medicinal chemistry, 2011, Nov-01, Volume: 19, Issue:21

    Topics: Amino Acid Transport Systems; Caco-2 Cells; Endocytosis; Humans; Kinetics; Models, Chemical; Models, Molecular; Molecular Conformation; Quantitative Structure-Activity Relationship; Substrate Specificity; Symporters

2011
Imino acid and related alicyclic amine levels in biological fluids.
    Journal of pharmacobio-dynamics, 1985, Volume: 8, Issue:7

    Topics: Amines; Animals; Body Fluids; Female; Gas Chromatography-Mass Spectrometry; Humans; Imino Acids; Male; Pipecolic Acids; Piperidines; Proline; Pyrrolidines; Rabbits; Rats; Rats, Inbred Strains

1985
Synthesis of conformationally constrained arginine and ornithine analogues based on the 3-substituted pyrrolidine framework.
    The Journal of organic chemistry, 2001, Sep-21, Volume: 66, Issue:19

    Topics: Arginine; Molecular Conformation; Molecular Mimicry; Ornithine; Peptides; Proline; Pyrrolidines

2001
Aqueous aldol catalysis by a nicotine metabolite.
    Journal of the American Chemical Society, 2002, Apr-03, Volume: 124, Issue:13

    Topics: Acetone; Benzaldehydes; Catalysis; Kinetics; Nicotine; Proline; Pyrrolidines; Substrate Specificity; Water

2002
[Conversion of glutamic acid in animal through L-pyrrolidine carboxylic acid into proline].
    Biochemische Zeitschrift, 1953, Volume: 324, Issue:4

    Topics: Animals; Carboxylic Acids; Glutamates; Glutamic Acid; Proline; Pyrrolidines

1953
[Synthesis of some pyrrolidine-2,5-dicarboxylic acid alkamine esters. 10. On synthesis of spasmolytic substances].
    Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft, 1955, Volume: 288, Issue:2

    Topics: Amino Acids; Dicarboxylic Acids; Drug Combinations; Esters; Parasympatholytics; Proline; Pyrrolidines; Sorbitol

1955
Total synthesis of (+)-cocaine via desymmetrization of a meso-dialdehyde.
    Organic letters, 2004, Sep-16, Volume: 6, Issue:19

    Topics: Aldehydes; Catalysis; Cocaine; Cyclization; Molecular Structure; Proline; Pyrrolidines; Stereoisomerism

2004
Design of temperature sensitive imprinted polymer hydrogels based on multiple-point hydrogen bonding.
    Macromolecular bioscience, 2004, Jul-14, Volume: 4, Issue:7

    Topics: Adsorption; Hydrogels; Hydrogen Bonding; Hydrogen-Ion Concentration; Proline; Pyrrolidines; Pyrrolidinones; Substrate Specificity; Temperature

2004
The impact of pyrrolidine hydroxylation on the conformation of proline-containing peptides.
    The Journal of organic chemistry, 2005, Feb-18, Volume: 70, Issue:4

    Topics: Dipeptides; Hydroxylation; Magnetic Resonance Spectroscopy; Molecular Conformation; Molecular Structure; Proline; Pyrrolidines; Thermodynamics

2005
Conformationally constrained PNA analogues: structural evolution toward DNA/RNA binding selectivity.
    Accounts of chemical research, 2005, Volume: 38, Issue:5

    Topics: Amino Acid Sequence; Directed Molecular Evolution; DNA; Molecular Sequence Data; Nucleic Acid Conformation; Peptide Nucleic Acids; Piperidines; Proline; Pyrrolidines; RNA; Substrate Specificity

2005
Direct, facile aldehyde and ketone alpha-selenenylation reactions promoted by L-prolinamide and pyrrolidine sulfonamide organocatalysts.
    The Journal of organic chemistry, 2005, Jul-08, Volume: 70, Issue:14

    Topics: Aldehydes; Catalysis; Ketones; Models, Chemical; Proline; Pyrrolidines; Selenium; Stereoisomerism; Sulfonamides

2005
Locked conformations for proline pyrrolidine ring: synthesis and conformational analysis of cis- and trans-4-tert-butylprolines.
    The Journal of organic chemistry, 2005, Aug-05, Volume: 70, Issue:16

    Topics: Crystallography, X-Ray; Molecular Conformation; Proline; Pyrrolidines; Stereoisomerism

2005
Theoretical and experimental investigation of the energetics of cis-trans proline isomerization in peptide models.
    The journal of physical chemistry. A, 2006, May-25, Volume: 110, Issue:20

    Topics: Acetamides; Algorithms; Binding Sites; Catalysis; Hydrogen Bonding; Isomerism; Models, Chemical; Nitrogen; Oxygen; Peptides; Peptidylprolyl Isomerase; Proline; Protons; Pyrrolidines; Serine; Thermodynamics; Threonine

2006
Modeling proline ligation in the heme-dependent CO sensor, CooA, using small-molecule analogs.
    Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2006, Volume: 11, Issue:5

    Topics: Bacterial Proteins; Carbon Monoxide; Computational Biology; Crystallography, X-Ray; Heme; Hemeproteins; Histidine; Imidazoles; Iron; Ligands; Models, Molecular; Molecular Structure; Proline; Pyrrolidines; Trans-Activators

2006
New highly potent GABA uptake inhibitors selective for GAT-1 and GAT-3 derived from (R)- and (S)-proline and homologous pyrrolidine-2-alkanoic acids.
    European journal of medicinal chemistry, 2006, Volume: 41, Issue:7

    Topics: Alkanes; Alkylation; Carboxylic Acids; GABA Plasma Membrane Transport Proteins; GABA Uptake Inhibitors; gamma-Aminobutyric Acid; Methylation; Molecular Structure; Proline; Pyrrolidines; Saponins; Stereoisomerism; Structure-Activity Relationship

2006
Ruthenium catalyzed decarbonylative arylation at sp3 carbon centers in pyrrolidine and piperidine heterocycles.
    Journal of the American Chemical Society, 2007, Sep-26, Volume: 129, Issue:38

    Topics: Boronic Acids; Carbon; Catalysis; Esters; Hydrocarbons, Aromatic; Hydroxyproline; Ketones; Models, Chemical; Piperidines; Proline; Pyrrolidines; Ruthenium; Stereoisomerism

2007
Catalysis of 3-pyrrolidinecarboxylic acid and related pyrrolidine derivatives in enantioselective anti-Mannich-type reactions: importance of the 3-acid group on pyrrolidine for stereocontrol.
    Journal of the American Chemical Society, 2008, Jan-23, Volume: 130, Issue:3

    Topics: Aldehydes; Catalysis; Imines; Ketones; Molecular Structure; Proline; Pyrrolidines; Stereoisomerism

2008
Catalytic asymmetric Michael reactions of acetaldehyde.
    Angewandte Chemie (International ed. in English), 2008, Volume: 47, Issue:25

    Topics: Acetaldehyde; Catalysis; Molecular Structure; Proline; Pyrrolidines; Stereoisomerism; Styrenes

2008
Synthesis, characterisation and in vitro cytotoxicity studies of a series of chiral platinum(II) complexes based on the 2-aminomethylpyrrolidine ligand: X-ray crystal structure of [PtCl2(R-dimepyrr)] (R-dimepyrr=N-dimethyl-2(R)-aminomethylpyrrolidine).
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:7

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Crystallography, X-Ray; Humans; Ligands; Models, Molecular; Organometallic Compounds; Platinum; Proline; Pyrrolidines; Stereoisomerism

2009
Synthesis and biological evaluation of 4-fluoroproline and 4-fluoropyrrolidine-2-acetic acid derivatives as new GABA uptake inhibitors.
    Bioorganic & medicinal chemistry, 2009, Sep-15, Volume: 17, Issue:18

    Topics: Acetates; Animals; Cell Line; GABA Uptake Inhibitors; gamma-Aminobutyric Acid; Inhibitory Concentration 50; Mice; Proline; Pyrrolidines; Structure-Activity Relationship

2009
Evaluation of the influence of proline, hydroxyproline or pyrrolidine in the presence of sodium nitrite on N-nitrosamine formation when heating cured meat.
    Analytica chimica acta, 2010, Jan-11, Volume: 657, Issue:2

    Topics: Carcinogens; Chromatography, Gas; Dimethylnitrosamine; Hydroxyproline; Limit of Detection; Meat; N-Nitrosopyrrolidine; Nitrosamines; Proline; Pyrrolidines; Sodium Nitrite; Temperature

2010
Effects of ring contraction on the conformational preferences of α-substituted proline analogs.
    Biopolymers, 2012, Volume: 98, Issue:2

    Topics: Amides; Azetidinecarboxylic Acid; Models, Molecular; Molecular Conformation; Peptides; Proline; Pyrrolidines; Quantum Theory

2012
Asymmetric Michael reaction of aldehydes with β-nitroalkenes catalyzed by pyrrolidine-camphor derived organocatalysts bearing hydrogen-bond donors.
    Chirality, 2012, Volume: 24, Issue:4

    Topics: Aldehydes; Alkenes; Camphor; Catalysis; Hydrogen Bonding; Models, Chemical; Proline; Pyrrolidines

2012
Synthesis and biological evaluation of 4-hydroxy-4-(4-methoxyphenyl)-substituted proline and pyrrolidin-2-ylacetic acid derivatives as GABA uptake inhibitors.
    Bioorganic & medicinal chemistry, 2013, Jan-15, Volume: 21, Issue:2

    Topics: Drug Evaluation, Preclinical; GABA Plasma Membrane Transport Proteins; GABA Uptake Inhibitors; Proline; Protein Binding; Pyrrolidines; Stereoisomerism; Structure-Activity Relationship

2013
Bromolactamization: key step in the stereoselective synthesis of enantiomerically pure, cis-configured perhydropyrroloquinoxalines.
    Chirality, 2014, Volume: 26, Issue:12

    Topics: Chemistry Techniques, Synthetic; Glutamates; Lactams; Lactams, Macrocyclic; Magnetic Resonance Spectroscopy; Molecular Structure; Proline; Pyrrolidines; Quinoxalines; Stereoisomerism

2014
Proline-catalyzed sequential syn-Mannich and [4 + 1]-annulation cascade reactions to form densely functionalized pyrrolidines.
    The Journal of organic chemistry, 2015, Feb-06, Volume: 80, Issue:3

    Topics: Aldehydes; Catalysis; Molecular Structure; Proline; Pyrrolidines; Stereoisomerism

2015