Compounds > pyrroles
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pyrroles and transforming growth factor beta

pyrroles has been researched along with transforming growth factor beta in 101 studies

Research

Studies (101)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (1.98)18.2507
2000's30 (29.70)29.6817
2010's63 (62.38)24.3611
2020's6 (5.94)2.80

Authors

AuthorsStudies
Nambi, P; Wu, HL1
Cao, Z; Cooper, ME; Cox, AJ; Gilbert, RE; Jandeleit-Dahm, K; Kelly, DJ1
Hayashi, H; Imamura, T; Ishisaki, A; Suzuki, M1
Bonardo, B; Deprez-Beauclair, P; Juhan-Vague, I; Laouenan, H; Lopez, S; Nalbone, G; Peiretti, F1
Fujita, N; Ishida, A; Kitazawa, R; Tsuruo, T1
Ho, S; Hoffman, MP; Kidder, BL; Kleinman, HK; Lakhani, S; Larsen, M; Steinberg, ZL1
Abián, J; Campistol, JM; Cases, A; Clària, J; Esmatjes, E; Iñigo, P; Lario, S; Mur, C; Rodela, S; Titos, E1
Brigande, JV; Chang, W; Fekete, DM; Wu, DK1
Asano, T; Hayakawa, M; Kosaka, T; Miyajima, A; Mizuguchi, Y1
Bulla, J; Florkovicová, I; Hetényi, L; Kotwica, J; Sanislo, P; Schaeffer, HJ; Sirotkin, AV1
Duman, S; Oreopoulos, DG; Sen, S; Sozmen, EY1
Ayame, H; Bando, T; Fukuda, N; Lai, YM; Matsuda, H; Matsumoto, K; Mugishima, H; Saito, S; Serie, K; Sugiyama, H; Ueno, T1
Abe, K; Akasaka, Y; Inoue, H; Sato, T1
Bailey, M; Denver, R; Krum, H; Martin, J1
Ihn, H; Jinnin, M; Tamaki, K1
Ayame, H; Bando, T; Fukuda, N; Matsuda, H; Matsumoto, K; Mugishima, H; Saito, S; Serie, K; Sugiyama, H; Tahira, Y; Ueno, T; Zhang, W1
Auberger, P; Bouvet, S; Fromigué, O; Haÿ, E; Jacquel, A; Marie, PJ; Modrowski, D1
Fukuda, N1
Amrani, M; Chester, AH; Latif, N; Osman, L; Yacoub, MH1
Hong, Z; Isenberg, B; Keirstead, SA; Lee, EH; Reyes, M; Ross, JJ; Tranquillo, RT; Verfaillie, CM; Weir, EK; Willenbring, B; Zeng, L1
Balcells, S; Blanch, J; Carreras, R; Díez-Perez, A; Enjuanes, A; Grinberg, D; Mellibovsky, L; Monllau, JC; Nogues, X; Pedro-Botet, J; Ruiz-Gaspa, S1
Bae, Y; Fujii, T; Hirakawa, K; Iwata, C; Kaminishi, M; Kano, MR; Kataoka, K; Kiyono, K; Komuro, A; Miyazono, K; Morishita, Y; Nishiyama, N; Oka, M; Ouchi, Y; Yashiro, M1
Bayés, B; Blanco, S; Bonet, J; Lauzurica, R; Navarro-Muñoz, M; Romero, R1
Andrys, C; Jamborova, G; Nachtigal, P; Pospechova, K; Pospisilova, N; Semecky, V; Solichova, D; Zdansky, P1
Ikeda, K; Matsui, H; Nakajima, Y; Sakabe, M; Sakata, H; Yamagishi, T; Yanagawa, N1
Abbruzzese, JL; Chiao, PJ; Fleming, JB; Ishiyama, S; Melisi, D; Sclabas, GM; Tortora, G; Xia, Q1
Fang, ZF; Li, XP; Liu, QM; Qiu, SF; Shen, XQ; Zhang, M; Zhao, SP; Zhou, SH1
Jaimes, EA; Raij, L; Schuman, IH; Zhou, MS1
Qureshi, HY; Ricci, G; Zafarullah, M1
Dolman, ME; Fretz, MM; Goldschmeding, R; Hennink, WE; Kok, RJ; Lacombe, M; Nguyen, TQ; Pato, J; Prakash, J; Storm, G1
Blanco-Colio, LM; Egido, J; Ortiz, A; Rodrigues-Díez, R; Rodríguez-Vita, J; Ruiz-Ortega, M; Sánchez-Galán, E; Sánchez-López, E; Santamaría, B1
Datta, PK; Halder, SK; Zhang, B; Zhang, S1
Antonaci, S; Dituri, F; Fransvea, E; Giannelli, G; Lupo, L; Mazzocca, A1
Abraham, C; Chalifour, LE; Dostanic, S; Meilleur, M; Mitmaker, B; Obrand, D; Schweitzer, M; Sheiner, N; Sugahara, T1
Banach-Petrosky, W; Biswas, S; Ganapathy, V; Ge, R; Grazioli, A; Kang, Y; Lonning, S; McPherson, J; Mundy, GR; Reiss, M; Xie, W; Yingling, JM1
Civantos, E; Egido, J; Lavoz, C; Mezzano, S; Ortiz, A; Rayego-Mateos, S; Rodrigues Díez, R; Rodrigues-Díez, R; Rodríguez-Vita, J; Ruiz-Ortega, M1
Guan, Y; Li, N; Su, G; Wang, L; Wang, S; Xie, W; Zhang, D; Zhao, P1
Chenausky, KL; Gauger, KJ; Murray, ME; Schneider, SS1
Kang, MH; Oh, DJ; Rhee, DJ; Villarreal, G1
Nonomura, N; Okuyama, A; Tsujihata, M; Tsujimura, A; Yoshioka, I1
Debus, J; Han, N; Huber, PE; Kleber, S; Lahn, M; Martin-Villalba, A; Peschke, P; Röhrich, M; Timke, C; Tuettenberg, J; Wirkner, U; Zhang, M1
Cabral, H; Chen, Q; Kano, MR; Kataoka, K; Kimura, M; Matsumoto, Y; Miyazono, K; Mizuno, K; Murakami, M; Nishiyama, N; Terada, Y; Uesaka, M1
Akhurst, RJ; Babb, JS; Barcellos-Hoff, MH; Bouquet, F; Demaria, S; DeWyngaert, JK; Formenti, SC; Hann, B; Lonning, SM; Pal, A; Pilones, KA1
Dhasarathy, A; Mav, D; Phadke, D; Shah, RR; Wade, PA1
Aung, H; Hirsch, CS; Toossi, Z; Wu, M1
Bickelhaupt, S; Dadrich, M; Flechsig, P; Gröne, HJ; Hahn, EW; Hauser, K; Huber, PE; Jenne, J; Lahn, M; Peschke, P; Timke, C; Wirkner, U; Yingling, J1
Barcellos-Hoff, MH; Hardee, ME; Lonning, SM; Marciscano, AE; Medina-Ramirez, CM; Narayana, A; Zagzag, D1
Boudreau, HE; Casterline, BW; Korzeniowska, A; Leto, TL; Rada, B1
Aoyama, T; Aoyama, Y; Fukuda, N; Hayashi, H; Kamei, T; Matsumoto, Y; Nagase, H; Nagashima, T; Tanaka, C; Ueno, T1
Ishii, K; Mori, A; Nakahara, T; Sakamoto, K; Ueda, K1
Beljaars, L; Lacombe, M; Poelstra, K; Post, E; Prakash, J; Reker-Smit, C; van Beuge, MM1
Gai, Z; Gui, T; Muragaki, Y; Shimokado, A; Sun, Y; Zhou, G1
Harmann, LM; Meyer, J; Petersen, M; Routhu, KV; Sonin, DL; Strande, JL; Wakatsuki, T1
De Santis, F; Dituri, F; Fabregat, I; Fernando, J; Giannelli, G; Mazzocca, A; Papappicco, P; Paradiso, A; Peidrò, FJ; Sabbà, C1
Abraham, D; Baliga, R; Denton, CP; Derrett-Smith, EC; Dooley, A; Gilbane, AJ; Hobbs, AJ; Holmes, AM; Khan, K; Trinder, SL1
Ali, R; Khanna, N; Kumar, S; Naqvi, RA; Rani, R; Rao, DN1
Grailer, JJ; Steeber, DA1
Kasak, L; Kauts, ML; Loog, M; Neuman, T; Piirsoo, A; Piirsoo, M; Tints, K; Uusen, P1
Bai, MH; Chen, HS; Jiang, XF; Liu, M; Wang, LF; Wang, YC; Zhang, T1
Almendro, V; Bessarabova, M; Caldas, C; Carver, K; Ekram, MB; Feng, J; Kim, JH; Liu, XS; Maruyama, R; Moen Vollan, HK; Nikolsky, Y; Peluffo, G; Polyak, K; Rueda, OM; Russnes, HG; Sun, H; Takagi, S; Vaske, C; Wu, Z; Yamamoto, S; Zhao, X; Zucca, M1
Bardot, E; Castillo-Martin, M; Castro, V; Cordon-Cardo, C; de la Iglesia-Vicente, J; Ezhkova, E; Iavarone, A; Llobet-Navas, D; Marshall, N; Olivan, M; Putcha, P; Rodriguez-Barrueco, R; Saucedo-Cuevas, L; Silva, JM1
Chen, X; Ding, H; Lan, L; Li, X; Lin, B; Luo, H; Wang, Y; Wu, J; Zhang, H1
Chung, YM; Han, S; Kim, BH; Lee, H; Lee, HG; Park, CH; Shin, K; Ye, SK1
Dooley, S; Goumans, MJ; Karkampouna, S; Kruithof-de Julio, M; Ten Dijke, P1
Akin, MM; Demir, T; Eren, K; Turgut, B1
Choi, SH; Jang, J; Lee, HJ; Lee, YJ; Nam, JK1
He, S; Shen, G; Wang, Y; Yin, T1
Gao, L; Gao, Y; Li, J; Shan, N; Wang, Y; Xu, F; Yi, Z; Yu, X; Zhao, C1
Bjarnason, GA; Butz, H; Dharsee, M; Ding, Q; Evans, KR; Khella, HWZ; Kupchak, P; Latif, A; Lianidou, E; Pasic, MD; Rotondo, F; Yousef, GM1
Chapman, SC; Ray, P1
Fukuda, N; Fukushima, A; Inami, M; Matsumoto, Y; Moriyama, M; Soma, M; Tsunemi, A; Ueno, T; Yamada, T1
Angelucci, E; Annese, T; Catacchio, I; Dammacco, F; De Veirman, K; Derudas, D; Desantis, V; Di Marzo, L; Frassanito, MA; Fumarulo, R; Maffia, M; Menu, E; Nico, B; Racanelli, V; Ria, R; Ribatti, D; Ruggieri, S; Vacca, A; Vanderkerken, K; Vergara, D1
Chen, XW; Diehn, M; Sun, JG; Wang, J; Zhang, LP1
Chang, LL; Chen, Y; Chen, ZB; Wang, DD; Zhao, PG; Zhou, TY; Zhu, H1
Cao, ZT; Chen, KG; Luo, YL; Shen, S; Wang, J; Wang, YC; Yu, XY; Zhao, G; Zuo, ZQ1
Alsina-Sanchis, E; Casanovas, O; Figueras, A; Graupera, M; Lahiguera, Á; Vidal, A; Villanueva, A; Viñals, F1
Fujita, K; Kainuma, S; Kozawa, O; Kuroyanagi, G; Matsushima-Nishiwaki, R; Otsuka, T; Tokuda, H; Yamamoto, N1
Gu, Y; Huang, X; Li, L; Luo, J; Sun, J; Wang, W; Wu, X; Yuan, H1
Huang, XR; Lai, W; Lan, HY; Lou, TQ; Ming-Kuen Tang, P; Szalai, AJ; Tang, Y; Xu, A1
Jiang, X; Qi, B; Wang, Z; Xia, H; Zhou, T1
Abraham, C; Dulai, PS; Sandborn, WJ; Vermeire, S1
Brounts, S; Galante, J; Gao, S; Gorski, D; Li, J; Luo, W; Plaas, A; Sandy, J; Trella, K1
Fang, J; Hua, J; Lv, C; Peng, S; Wei, Y; Zhao, S1
Asano, Y; Fukushima, S; Hashizume, Y; Ide, M; Ihn, H; Jinnin, M; Kajihara, I; Tomizawa, Y; Wang, Z1
Burghardt, I; Papa, E; Szabó, E; Ventura, E; Weiss, T; Weller, M1
Chen, CL; Chen, JJ; Chung, CL; Huang, YB; Kao, YC; Knölker, HJ; Lin, MH; Martin, R; Wang, SW; Wu, DC1
Ji, X; Li, J; Liu, Y; Tan, R; Wang, H; Wang, L; Wu, Z; Zhang, Y; Zhong, X; Zhu, M1
Chen, CL; Chih-Ling, C; Kao, YC; Knölker, HJ; Martin, R; Shiao, MS; Shih-Wei, W1
Huang, XR; Lan, HY; Meng, XM; Zhang, Y1
Adhyatmika, A; Adlia, A; de Jong, KP; Luangmonkong, T; Mutsaers, HAM; Olinga, P; Oosterhuis, D; Suriguga, S; Suthisisang, C1
Bai, Y; Liu, M; Shen, D; Tao, S; Wang, T; Zhang, W1
Liang, DY; Liu, QH; Peng, YB; Shen, J; Wang, Q; Xu, WH1
Bonini, MG; Castellon, M; Chen, J; Comhair, S; Erzurum, S; Machado, RF; Mao, M; Minshall, RD; Oliveira, SDS; Raj, JU; Silva, CLM1
Gao, L; Li, R; Li, Y; Lu, W; Peng, M; Qiu, C; Shan, Y; Wang, X; Zheng, X1
Ding, L; Huang, T; Jiang, H; Liang, Y; Liu, Y; Sattar, S; Shang, Y; Wang, M; Wei, Y; Wu, B; Yang, T; Zhang, D; Zhou, F1
Chen, X; Chen, XP; Datta, PK; Dong, SL; Dong, W; Leng, C; Luo, X; Wang, C; Yin, P; Zhang, BH; Zhang, BX1
Bin, Y; Chen, X; Chen, Y; Li, G; Yan, H; Zhou, X1
Fang, Q; Liu, P; Ma, D; Ni, M; Pan, C; Wang, J; Zhang, S1
Basta, MD; Paulson, H; Walker, JL1
Chang, Y; Dai, X; Ji, S; Jiang, Z; Li, B; Li, C; Li, D; Liang, R; Ruan, S; Sun, J; Wang, Z; Yang, M; Zhao, H1
Chen, J; Huang, XR; Lan, HY; Lee, CS; Li, M; Lian, GY; Mak, TS; Tang, PM; Wan, Y; Wang, QM; Wang, ZY; Yu, XQ; Zhang, J1

Reviews

2 review(s) available for pyrroles and transforming growth factor beta

ArticleYear
Role of hyperlipidemia in progressive renal disease: focus on diabetic nephropathy.
    Kidney international. Supplement, 1999, Volume: 71

    Topics: Animals; Anticholesteremic Agents; Atorvastatin; Clinical Trials as Topic; Diabetic Nephropathies; Disease Progression; Gene Expression; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; In Situ Hybridization; Kidney Diseases; Kidney Glomerulus; Lovastatin; Male; Nephrectomy; Pravastatin; Pyrroles; Rats; Rats, Sprague-Dawley; Simvastatin; Transforming Growth Factor beta

1999
Lessons Learned From Trials Targeting Cytokine Pathways in Patients With Inflammatory Bowel Diseases.
    Gastroenterology, 2017, Volume: 152, Issue:2

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Cytokines; Humans; Inflammatory Bowel Diseases; Interleukin-23; Janus Kinases; Lysophospholipids; Molecular Targeted Therapy; Oligonucleotides; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Signal Transduction; Smad7 Protein; Sphingosine; Th17 Cells; Transforming Growth Factor beta; Ustekinumab

2017

Trials

2 trial(s) available for pyrroles and transforming growth factor beta

ArticleYear
Atorvastatin treatment in the short term: does it induce renoprotection or vasculoprotection in renal transplantation?
    Transplantation proceedings, 2007, Volume: 39, Issue:7

    Topics: Adult; Aged; Atorvastatin; Blood Pressure; Cohort Studies; Dyslipidemias; Female; Glomerular Filtration Rate; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Immunosuppressive Agents; Kidney Transplantation; Male; Middle Aged; Postoperative Complications; Proteinuria; Pyrroles; Transforming Growth Factor beta

2007
Effect of oral atorvastatin on CD4+CD25+ regulatory T cells, FoxP3 expression, and prognosis in patients with ST-segment elevated myocardial infarction before primary percutaneous coronary intervention.
    Journal of cardiovascular pharmacology, 2011, Volume: 57, Issue:5

    Topics: Angioplasty, Balloon, Coronary; Atorvastatin; CD4 Antigens; Coronary Vessels; Electrocardiography; Female; Flow Cytometry; Forkhead Transcription Factors; Heptanoic Acids; Humans; Immunologic Factors; Interferon-gamma; Interleukin-2 Receptor alpha Subunit; Lymphocyte Count; Male; Middle Aged; Myocardial Infarction; Prognosis; Pyrroles; T-Lymphocytes, Regulatory; Transforming Growth Factor beta; Treatment Outcome

2011

Other Studies

97 other study(ies) available for pyrroles and transforming growth factor beta

ArticleYear
Transforming growth factor-beta-mediated proliferation of renal tubular epithelial cells involves pertussis toxin-sensitive G protein-and protein kinase C-dependent pathways.
    Pharmacology, 1998, Volume: 57, Issue:1

    Topics: Animals; Cell Division; Cell Line; Dose-Response Relationship, Drug; Enzyme Inhibitors; GTP-Binding Proteins; Indoles; Pertussis Toxin; Protein Kinase C; Pyrroles; Signal Transduction; Thymidine; Transforming Growth Factor beta; Tritium; Virulence Factors, Bordetella

1998
BMP-2 augments FGF-induced differentiation of PC12 cells through upregulation of FGF receptor-1 expression.
    Journal of cell science, 2001, Volume: 114, Issue:Pt 7

    Topics: Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Cell Differentiation; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Fibroblast Growth Factor 1; Fibroblast Growth Factor 2; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nerve Growth Factor; Neurites; PC12 Cells; Peptides; Pyrroles; Rats; Receptor Protein-Tyrosine Kinases; Receptor, Fibroblast Growth Factor, Type 1; Receptors, Fibroblast Growth Factor; RNA, Messenger; Signal Transduction; Smad7 Protein; Trans-Activators; Transforming Growth Factor beta; Up-Regulation

2001
Effect of atorvastatin on plasminogen activator inhibitor type-1 synthesis in human monocytes/macrophages.
    Journal of cardiovascular pharmacology, 2001, Volume: 37, Issue:6

    Topics: Atorvastatin; Heptanoic Acids; HL-60 Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Macrophages; Monocytes; Plasminogen Activator Inhibitor 1; Pyrroles; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha

2001
Transforming growth factor-beta induces expression of receptor activator of NF-kappa B ligand in vascular endothelial cells derived from bone.
    The Journal of biological chemistry, 2002, Jul-19, Volume: 277, Issue:29

    Topics: Animals; Bone and Bones; Carbazoles; Carrier Proteins; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; Endothelium, Vascular; Enzyme Inhibitors; Humans; Imidazoles; Indoles; Membrane Glycoproteins; Mice; Mitogen-Activated Protein Kinases; NF-kappa B; Osteoclasts; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Promoter Regions, Genetic; Pyridines; Pyrroles; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; RNA, Messenger; Transforming Growth Factor beta

2002
Gene expression profiles of mouse submandibular gland development: FGFR1 regulates branching morphogenesis in vitro through BMP- and FGF-dependent mechanisms.
    Development (Cambridge, England), 2002, Volume: 129, Issue:24

    Topics: Animals; Apoptosis; Bone Morphogenetic Protein 7; Bone Morphogenetic Proteins; Cell Division; Dose-Response Relationship, Drug; Fibroblast Growth Factor 10; Fibroblast Growth Factor 7; Fibroblast Growth Factors; Gene Expression Regulation, Developmental; Mesoderm; Mice; Mice, Knockout; Oligonucleotide Array Sequence Analysis; Oligonucleotides, Antisense; Organ Culture Techniques; Protein Isoforms; Pyrroles; Receptor Protein-Tyrosine Kinases; Receptor, Fibroblast Growth Factor, Type 1; Receptors, Fibroblast Growth Factor; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Submandibular Gland; Time Factors; Transforming Growth Factor beta

2002
Cigarette smoke concentrate increases 8-epi-PGF2alpha and TGFbeta1 secretion in rat mesangial cells.
    Life sciences, 2004, Jun-18, Volume: 75, Issue:5

    Topics: Animals; Cells, Cultured; Chromatography, High Pressure Liquid; Dinoprost; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glomerular Mesangium; Mesylates; Nicotiana; Protein Kinase C; Pyrroles; Rats; Rats, Sprague-Dawley; Smoke; Tars; Transforming Growth Factor beta; Transforming Growth Factor beta1

2004
The development of semicircular canals in the inner ear: role of FGFs in sensory cristae.
    Development (Cambridge, England), 2004, Volume: 131, Issue:17

    Topics: Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Protein 7; Bone Morphogenetic Proteins; Carrier Proteins; Cell Lineage; Chick Embryo; Ear, Inner; Fibroblast Growth Factor 10; Fibroblast Growth Factor 2; Fibroblast Growth Factor 3; Fibroblast Growth Factors; In Situ Hybridization; Models, Biological; Mutation; Phenotype; Protein Structure, Tertiary; Proteins; Pyrroles; Retroviridae; Time Factors; Transforming Growth Factor beta; Zebrafish Proteins

2004
Atorvastatin ameliorates renal tissue damage in unilateral ureteral obstruction.
    The Journal of urology, 2004, Volume: 172, Issue:6 Pt 1

    Topics: Animals; Atorvastatin; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney; Kidney Diseases; Pyrroles; Rats; Rats, Sprague-Dawley; Transforming Growth Factor beta; Ureteral Obstruction

2004
Thrombopoietin regulates proliferation, apoptosis, secretory activity and intracellular messengers in porcine ovarian follicular cells: involvement of protein kinase A.
    The Journal of endocrinology, 2004, Volume: 183, Issue:3

    Topics: Androstenedione; Animals; Apoptosis; Carbazoles; CDC2 Protein Kinase; Cell Proliferation; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Estradiol; Female; Immunoblotting; Immunohistochemistry; Indoles; Inhibins; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor I; Ovarian Follicle; Oxytocin; Phosphotyrosine; Progesterone; Pyrroles; Swine; Thrombopoietin; Transforming Growth Factor beta

2004
Atorvastatin improves peritoneal sclerosis induced by hypertonic PD solution in rats.
    The International journal of artificial organs, 2005, Volume: 28, Issue:2

    Topics: Animals; Atorvastatin; Cholesterol; Glucose; Glucose Solution, Hypertonic; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Microscopy; Peritoneum; Pyrroles; Rats; Rats, Wistar; Sclerosis; Transforming Growth Factor beta; Transforming Growth Factor beta1; Ultrafiltration; Urea; Vascular Endothelial Growth Factor A

2005
Synthetic pyrrole-imidazole polyamide inhibits expression of the human transforming growth factor-beta1 gene.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 315, Issue:2

    Topics: Blotting, Western; Cells, Cultured; Deoxyribonucleases, Type II Site-Specific; DNA; Electrophoretic Mobility Shift Assay; Endothelial Cells; Gene Expression Regulation; Humans; Indicators and Reagents; Nylons; Oligonucleotides; Promoter Regions, Genetic; Pyrroles; Reverse Transcriptase Polymerase Chain Reaction; Transforming Growth Factor beta; Transforming Growth Factor beta1; Tubulin

2005
Regulation of neurokinin-1 receptor messenger RNA expression in synovial fibroblasts of patients with rheumatoid arthritis.
    Neuropeptides, 2005, Volume: 39, Issue:5

    Topics: Arthritis, Rheumatoid; Cells, Cultured; Fibroblast Growth Factors; Fibroblasts; Humans; Interleukin-1; Protein Isoforms; Pyrroles; Receptors, Neurokinin-1; Receptors, Neurokinin-2; RNA, Messenger; Synovial Membrane; Transforming Growth Factor beta; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha

2005
In vitro inhibitory effects of atorvastatin on cardiac fibroblasts: implications for ventricular remodelling.
    Clinical and experimental pharmacology & physiology, 2005, Volume: 32, Issue:9

    Topics: Angiotensin II; Animals; Atorvastatin; Cells, Cultured; Collagen; Connective Tissue Growth Factor; Dose-Response Relationship, Drug; Extracellular Matrix; Fibroblasts; Heart; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; Myocardium; Procollagen; Pyrroles; Rats; Transforming Growth Factor beta; Transforming Growth Factor beta1; Ventricular Remodeling

2005
Characterization of SIS3, a novel specific inhibitor of Smad3, and its effect on transforming growth factor-beta1-induced extracellular matrix expression.
    Molecular pharmacology, 2006, Volume: 69, Issue:2

    Topics: Cell Differentiation; Collagen Type I; Extracellular Matrix; Fibroblasts; Genes, Reporter; Humans; Isoquinolines; Luciferases; Phosphorylation; Promoter Regions, Genetic; Pyridines; Pyrroles; Scleroderma, Systemic; Signal Transduction; Skin; Smad3 Protein; Transfection; Transforming Growth Factor beta; Transforming Growth Factor beta1; Up-Regulation

2006
Development of gene silencing pyrrole-imidazole polyamide targeting the TGF-beta1 promoter for treatment of progressive renal diseases.
    Journal of the American Society of Nephrology : JASN, 2006, Volume: 17, Issue:2

    Topics: Animals; Cell Culture Techniques; Gene Silencing; Imidazoles; Kidney Diseases; Mesangial Cells; Nylons; Promoter Regions, Genetic; Pyrroles; Rats; Rats, Inbred Dahl; Rats, Wistar; RNA, Messenger; Transcription Factor AP-1; Transforming Growth Factor beta; Transforming Growth Factor beta1

2006
RhoA GTPase inactivation by statins induces osteosarcoma cell apoptosis by inhibiting p42/p44-MAPKs-Bcl-2 signaling independently of BMP-2 and cell differentiation.
    Cell death and differentiation, 2006, Volume: 13, Issue:11

    Topics: Anticholesteremic Agents; Apoptosis; Atorvastatin; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Caspases; Cell Differentiation; Cell Survival; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation, Neoplastic; Heptanoic Acids; Humans; Osteosarcoma; Phenotype; Phosphorylation; Polyisoprenyl Phosphates; Protein Transport; Proto-Oncogene Proteins c-bcl-2; Pyridines; Pyrroles; rhoA GTP-Binding Protein; RNA, Messenger; Signal Transduction; Simvastatin; Transforming Growth Factor beta

2006
Development of gene therapies for cardiovascular and renal diseases by nucleic acid medicines.
    Medicinal chemistry (Shariqah (United Arab Emirates)), 2006, Volume: 2, Issue:1

    Topics: Amides; Animals; Base Sequence; Cardiovascular Diseases; DNA, Antisense; Gene Silencing; Genetic Therapy; Hypertension, Renovascular; Imidazoles; Kidney Diseases; Male; Oligonucleotides, Antisense; Platelet-Derived Growth Factor; Promoter Regions, Genetic; Pyrroles; Rats; RNA, Catalytic; Swine; Transforming Growth Factor beta; Transforming Growth Factor beta1; Tunica Intima

2006
Role of human valve interstitial cells in valve calcification and their response to atorvastatin.
    Circulation, 2006, Jul-04, Volume: 114, Issue:1 Suppl

    Topics: Aged; Alkaline Phosphatase; Aortic Valve; Aortic Valve Stenosis; Atorvastatin; Bone Morphogenetic Protein 2; Bone Morphogenetic Protein 4; Bone Morphogenetic Protein 7; Bone Morphogenetic Proteins; Calcinosis; Cell Differentiation; Cells, Cultured; Connective Tissue Cells; Culture Media; Fibrosis; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Middle Aged; Osteoblasts; Osteocalcin; Pyrroles; Transforming Growth Factor beta; Transforming Growth Factor beta1; Transforming Growth Factor beta3

2006
Cytokine-induced differentiation of multipotent adult progenitor cells into functional smooth muscle cells.
    The Journal of clinical investigation, 2006, Volume: 116, Issue:12

    Topics: Animals; Animals, Newborn; Becaplermin; Calcium Channel Agonists; Calcium Channels, L-Type; Cell Differentiation; Cells, Cultured; Cytokines; Fibrin; Flow Cytometry; Gene Expression; Humans; Mice; Mice, Inbred C57BL; Multipotent Stem Cells; Myocytes, Smooth Muscle; Patch-Clamp Techniques; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Pyrroles; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Swine; Transcription Factors; Transforming Growth Factor beta

2006
Simvastatin and atorvastatin enhance gene expression of collagen type 1 and osteocalcin in primary human osteoblasts and MG-63 cultures.
    Journal of cellular biochemistry, 2007, Aug-15, Volume: 101, Issue:6

    Topics: Aged; Atorvastatin; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Cell Line, Tumor; Cell Proliferation; Cells, Cultured; Collagen Type I; Gene Expression Regulation; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Osteoblasts; Osteocalcin; Osteosarcoma; Pyrroles; Simvastatin; Transforming Growth Factor beta

2007
Improvement of cancer-targeting therapy, using nanocarriers for intractable solid tumors by inhibition of TGF-beta signaling.
    Proceedings of the National Academy of Sciences of the United States of America, 2007, Feb-27, Volume: 104, Issue:9

    Topics: Animals; Cell Line, Tumor; Drug Delivery Systems; Endothelium, Vascular; Humans; Immunohistochemistry; Mice; Mice, Inbred BALB C; Nanoparticles; Neoplasms; Protein Serine-Threonine Kinases; Pyrazoles; Pyrroles; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Signal Transduction; Transforming Growth Factor beta

2007
Endothelial expression of endoglin in normocholesterolemic and hypercholesterolemic C57BL/6J mice before and after atorvastatin treatment.
    Canadian journal of physiology and pharmacology, 2007, Volume: 85, Issue:8

    Topics: Animals; Atorvastatin; Endoglin; Endothelium, Vascular; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred C57BL; Nitric Oxide; Platelet Endothelial Cell Adhesion Molecule-1; Pyrroles; Transforming Growth Factor beta

2007
Induction of initial heart alpha-actin, smooth muscle alpha-actin, in chick pregastrula epiblast: the role of hypoblast and fibroblast growth factor-8.
    Development, growth & differentiation, 2008, Volume: 50, Issue:3

    Topics: Actins; Animals; Biomarkers; Chick Embryo; Fetal Proteins; Fibroblast Growth Factor 8; Gene Expression Regulation, Developmental; Germ Layers; Glycoproteins; Heart; Intercellular Signaling Peptides and Proteins; Mesoderm; Nodal Protein; Organ Culture Techniques; Protein Kinase Inhibitors; Pyrroles; Smad2 Protein; T-Box Domain Proteins; Transforming Growth Factor beta; Troponin T

2008
LY2109761, a novel transforming growth factor beta receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis.
    Molecular cancer therapeutics, 2008, Volume: 7, Issue:4

    Topics: Animals; Anoikis; Antimetabolites, Antineoplastic; Apoptosis; Cell Movement; Deoxycytidine; Drug Therapy, Combination; Gemcitabine; Humans; Lung Neoplasms; Mice; Mice, Inbred C57BL; Mice, Nude; Neoplasm Invasiveness; Neovascularization, Pathologic; Pancreatic Neoplasms; Phosphorylation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrazoles; Pyrroles; Receptor, Transforming Growth Factor-beta Type I; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Ribonucleotide Reductases; Signal Transduction; Smad2 Protein; Survival Rate; Transforming Growth Factor beta; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2008
Atorvastatin downregulates BMP-2 expression induced by oxidized low-density lipoprotein in human umbilical vein endothelial cells.
    Circulation journal : official journal of the Japanese Circulation Society, 2008, Volume: 72, Issue:5

    Topics: Antioxidants; Atorvastatin; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Cell Nucleus; Cells, Cultured; Cytoplasm; Down-Regulation; Drug Interactions; Endothelial Cells; Gene Expression; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipoproteins, LDL; Malondialdehyde; Proline; Pyrroles; RNA, Messenger; Superoxide Dismutase; Thiocarbamates; Transcription Factor RelA; Transforming Growth Factor beta; Umbilical Veins

2008
Renoprotection by statins is linked to a decrease in renal oxidative stress, TGF-beta, and fibronectin with concomitant increase in nitric oxide bioavailability.
    American journal of physiology. Renal physiology, 2008, Volume: 295, Issue:1

    Topics: Animals; Atorvastatin; Biological Availability; Blood Pressure; Chemokine CCL2; Fibronectins; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney; Kidney Failure, Chronic; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Proteinuria; Pyrroles; Rats; Rats, Inbred Dahl; RNA, Messenger; Scavenger Receptors, Class E; Transforming Growth Factor beta

2008
Smad signaling pathway is a pivotal component of tissue inhibitor of metalloproteinases-3 regulation by transforming growth factor beta in human chondrocytes.
    Biochimica et biophysica acta, 2008, Volume: 1783, Issue:9

    Topics: Cells, Cultured; Chondrocytes; Chromatin Immunoprecipitation; Humans; Isoquinolines; Promoter Regions, Genetic; Pyridines; Pyrroles; RNA Interference; Signal Transduction; Smad Proteins; Smad2 Protein; Smad3 Protein; Smad4 Protein; Tissue Inhibitor of Metalloproteinase-3; Transforming Growth Factor beta

2008
Intervention in growth factor activated signaling pathways by renally targeted kinase inhibitors.
    Journal of controlled release : official journal of the Controlled Release Society, 2008, Dec-18, Volume: 132, Issue:3

    Topics: Cells, Cultured; Chemistry, Pharmaceutical; Drug Carriers; Endocytosis; Epidermal Growth Factor; ErbB Receptors; Erlotinib Hydrochloride; Fibrosis; Gene Expression Regulation; Humans; Intercellular Signaling Peptides and Proteins; Kidney Tubules, Proximal; Kinetics; Muramidase; Phosphorylation; Protein Kinase Inhibitors; Pyrazoles; Pyrroles; Quinazolines; Receptors, Transforming Growth Factor beta; Signal Transduction; Transforming Growth Factor beta

2008
Essential role of TGF-beta/Smad pathway on statin dependent vascular smooth muscle cell regulation.
    PloS one, 2008, Volume: 3, Issue:12

    Topics: Animals; Anticholesteremic Agents; Apolipoproteins E; Apoptosis; Atherosclerosis; Atorvastatin; Cells, Cultured; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mice; Mice, Knockout; Models, Biological; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Pyrroles; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Smad Proteins; Transforming Growth Factor beta

2008
Targeting transforming growth factor-beta signaling in liver metastasis of colon cancer.
    Cancer letters, 2009, May-08, Volume: 277, Issue:1

    Topics: Animals; Cell Line, Tumor; Cell Movement; Colonic Neoplasms; Genes, ras; Humans; Liver Neoplasms; Mice; Mice, Inbred BALB C; Mutation; Neoplasm Invasiveness; Pyrazoles; Pyrroles; Signal Transduction; Smad Proteins; Transforming Growth Factor beta

2009
Down-regulation of connective tissue growth factor by inhibition of transforming growth factor beta blocks the tumor-stroma cross-talk and tumor progression in hepatocellular carcinoma.
    Hepatology (Baltimore, Md.), 2010, Volume: 51, Issue:2

    Topics: Carcinoma, Hepatocellular; Connective Tissue Growth Factor; Disease Progression; Down-Regulation; Humans; Liver Neoplasms; Pyrazoles; Pyrroles; Transforming Growth Factor beta; Tumor Cells, Cultured

2010
Atorvastatin modulates matrix metalloproteinase expression, activity, and signaling in abdominal aortic aneurysms.
    Vascular and endovascular surgery, 2010, Volume: 44, Issue:2

    Topics: Aged; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Atorvastatin; Down-Regulation; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Matrix Metalloproteinases; Phosphorylation; Pyrroles; Signal Transduction; Smad2 Protein; Tissue Inhibitor of Metalloproteinases; Transforming Growth Factor beta

2010
Targeting the Transforming Growth Factor-beta pathway inhibits human basal-like breast cancer metastasis.
    Molecular cancer, 2010, May-26, Volume: 9

    Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Female; Humans; Mice; Mice, Nude; Neoplasm Metastasis; Neovascularization, Pathologic; Pyrazoles; Pyrroles; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Transforming Growth Factor beta; Xenograft Model Antitumor Assays

2010
Statins inhibit angiotensin II/Smad pathway and related vascular fibrosis, by a TGF-β-independent process.
    PloS one, 2010, Nov-30, Volume: 5, Issue:11

    Topics: Angiotensin II; Animals; Aorta; Atorvastatin; Blotting, Western; Cells, Cultured; Fibrosis; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyrroles; Rats; Rats, Wistar; Signal Transduction; Simvastatin; Smad Proteins; Transforming Growth Factor beta; Vasoconstrictor Agents

2010
SFRP1 reduction results in an increased sensitivity to TGF-β signaling.
    BMC cancer, 2011, Feb-08, Volume: 11

    Topics: Animals; Down-Regulation; Epithelial-Mesenchymal Transition; Gene Knockdown Techniques; Homeodomain Proteins; Humans; Intercellular Signaling Peptides and Proteins; Membrane Proteins; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Pyrazoles; Pyrroles; Repressor Proteins; Signal Transduction; Telomerase; Transforming Growth Factor beta; Zinc Finger E-box Binding Homeobox 2

2011
Coordinated regulation of extracellular matrix synthesis by the microRNA-29 family in the trabecular meshwork.
    Investigative ophthalmology & visual science, 2011, May-01, Volume: 52, Issue:6

    Topics: Adolescent; Adult; Aged; Cell Line; Child; Extracellular Matrix; Extracellular Matrix Proteins; Gene Expression; Humans; Immunoblotting; Isoquinolines; MicroRNAs; Middle Aged; Pyridines; Pyrroles; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Smad3 Protein; Tissue Donors; Trabecular Meshwork; Transfection; Transforming Growth Factor beta

2011
Why does atorvastatin inhibit renal crystal retention?
    Urological research, 2011, Volume: 39, Issue:5

    Topics: Animals; Atorvastatin; Calcium Oxalate; Catalase; Crystallization; Disease Models, Animal; Heptanoic Acids; Kidney; Kidney Calculi; Male; NADH, NADPH Oxidoreductases; NADPH Oxidase 1; NADPH Oxidases; Pyrroles; rac1 GTP-Binding Protein; Rats; Rats, Sprague-Dawley; Rats, Wistar; Superoxide Dismutase; Transforming Growth Factor beta

2011
Blockade of TGF-β signaling by the TGFβR-I kinase inhibitor LY2109761 enhances radiation response and prolongs survival in glioblastoma.
    Cancer research, 2011, Dec-01, Volume: 71, Issue:23

    Topics: Animals; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; DNA Damage; DNA Repair; Glioblastoma; Humans; Mesenchymal Stem Cells; Mice; Mice, Inbred BALB C; Mice, SCID; Microarray Analysis; Neoplasm Invasiveness; Neoplastic Stem Cells; Neovascularization, Pathologic; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrazoles; Pyrroles; Radiation Tolerance; Radiation-Sensitizing Agents; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Signal Transduction; Smad2 Protein; Transforming Growth Factor beta; Xenograft Model Antitumor Assays

2011
Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size.
    Nature nanotechnology, 2011, Oct-23, Volume: 6, Issue:12

    Topics: Animals; Antineoplastic Agents; Drug Carriers; Humans; Liposomes; Mice; Mice, Inbred BALB C; Micelles; Organoplatinum Compounds; Pancreatic Neoplasms; Particle Size; Permeability; Polyethylene Glycols; Pyrazoles; Pyrroles; Transforming Growth Factor beta

2011
TGFβ1 inhibition increases the radiosensitivity of breast cancer cells in vitro and promotes tumor control by radiation in vivo.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2011, Nov-01, Volume: 17, Issue:21

    Topics: Amino Acids; Animals; Breast Neoplasms; Cell Growth Processes; Cell Line, Tumor; Combined Modality Therapy; Female; Humans; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, SCID; Protein Serine-Threonine Kinases; Pyrazoles; Pyrroles; Radiation-Sensitizing Agents; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Transforming Growth Factor beta; Transforming Growth Factor beta1; Xanthenes; Xenograft Model Antitumor Assays

2011
The transcription factors Snail and Slug activate the transforming growth factor-beta signaling pathway in breast cancer.
    PloS one, 2011, Volume: 6, Issue:10

    Topics: Acetylation; Benzamides; Breast Neoplasms; Cell Differentiation; Cell Line, Tumor; Cell Movement; Dioxoles; Down-Regulation; Epithelial-Mesenchymal Transition; Female; Genetic Loci; Histones; Humans; Intercellular Junctions; Mammary Glands, Human; Phenotype; Protein Serine-Threonine Kinases; Pyrazoles; Pyrroles; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; RNA, Messenger; Signal Transduction; Snail Family Transcription Factors; Substrate Specificity; Transcription Factors; Transcription, Genetic; Transforming Growth Factor beta

2011
Inhibition of Mycobacterium tuberculosis-induced signalling by transforming growth factor-β in human mononuclear phagocytes.
    Scandinavian journal of immunology, 2012, Volume: 75, Issue:3

    Topics: Benzamides; Dioxoles; Humans; Isoquinolines; Leukocytes, Mononuclear; Mycobacterium tuberculosis; Phagocytes; Plasminogen Activators; Plasminogen Inactivators; Pyridines; Pyrroles; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Signal Transduction; Smad3 Protein; Transforming Growth Factor beta; Tuberculosis

2012
LY2109761 attenuates radiation-induced pulmonary murine fibrosis via reversal of TGF-β and BMP-associated proinflammatory and proangiogenic signals.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2012, Jul-01, Volume: 18, Issue:13

    Topics: Angiogenic Proteins; Animals; Bone Morphogenetic Proteins; Cells, Cultured; Cone-Beam Computed Tomography; Female; Fibroblasts; Gene Expression Profiling; Humans; Inflammation Mediators; Lung; Mice; Mice, Inbred C57BL; Oligonucleotide Array Sequence Analysis; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Pyrazoles; Pyrroles; Radiation Injuries, Experimental; Radiation Pneumonitis; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Smad2 Protein; Transcription, Genetic; Transforming Growth Factor beta

2012
Resistance of glioblastoma-initiating cells to radiation mediated by the tumor microenvironment can be abolished by inhibiting transforming growth factor-β.
    Cancer research, 2012, Aug-15, Volume: 72, Issue:16

    Topics: Animals; Antibodies, Neutralizing; Brain Neoplasms; Cell Line, Tumor; Combined Modality Therapy; DNA Damage; DNA, Neoplasm; Female; Glioblastoma; Humans; Mice; Mice, Inbred C57BL; Mink; Neoplastic Stem Cells; Neural Stem Cells; Pyrazoles; Pyrroles; Radiation Tolerance; Radiation-Sensitizing Agents; Signal Transduction; Transforming Growth Factor beta; Tumor Microenvironment

2012
Nox4 involvement in TGF-beta and SMAD3-driven induction of the epithelial-to-mesenchymal transition and migration of breast epithelial cells.
    Free radical biology & medicine, 2012, Oct-01, Volume: 53, Issue:7

    Topics: Cell Line, Tumor; Cell Movement; Cell Proliferation; Epithelial Cells; Epithelial-Mesenchymal Transition; Female; Fibronectins; Gene Expression Regulation; Humans; Isoquinolines; Mammary Glands, Human; NADPH Oxidase 4; NADPH Oxidases; Pyridines; Pyrroles; Reactive Oxygen Species; Receptors, Transforming Growth Factor beta; RNA, Small Interfering; Signal Transduction; Smad3 Protein; Transforming Growth Factor beta

2012
Quantitation of pyrrole-imidazole polyamide in rat plasma by high-performance liquid chromatography coupled with UV detection.
    Journal of biomedicine & biotechnology, 2012, Volume: 2012

    Topics: Amides; Animals; Chromatography, High Pressure Liquid; Drug Stability; Imidazoles; Male; Methanol; Phenacetin; Pyrroles; Rats; Rats, Wistar; Reproducibility of Results; Scavenger Receptors, Class E; Spectrophotometry, Ultraviolet; Transforming Growth Factor beta

2012
Protective effects of TGF-β inhibitors in a rat model of NMDA-induced retinal degeneration.
    European journal of pharmacology, 2013, Jan-15, Volume: 699, Issue:1-3

    Topics: Animals; Benzamides; Capillaries; Dioxoles; Disease Models, Animal; Intravitreal Injections; Male; N-Methylaspartate; Pyrazoles; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Transforming Growth Factor beta; Retinal Diseases; Retinal Ganglion Cells; Retinal Vessels; Transforming Growth Factor beta

2013
Enhanced effectivity of an ALK5-inhibitor after cell-specific delivery to hepatic stellate cells in mice with liver injury.
    PloS one, 2013, Volume: 8, Issue:2

    Topics: Animals; Collagen; Disease Models, Animal; Hepatic Stellate Cells; Hepatocytes; Humans; Liver Cirrhosis; Male; Mice; Protein Serine-Threonine Kinases; Pyrazoles; Pyrroles; Rats; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Transforming Growth Factor beta

2013
The loss of Trps1 suppresses ureteric bud branching because of the activation of TGF-β signaling.
    Developmental biology, 2013, May-15, Volume: 377, Issue:2

    Topics: Animals; Blotting, Western; GATA Transcription Factors; Gene Expression Regulation, Developmental; Immunohistochemistry; In Situ Nick-End Labeling; Isoquinolines; Mice; Mice, Knockout; Oligonucleotide Array Sequence Analysis; Pyridines; Pyrroles; Repressor Proteins; Signal Transduction; Smad3 Protein; Transforming Growth Factor beta; Ureter

2013
Protease-activated receptor 1 inhibition by SCH79797 attenuates left ventricular remodeling and profibrotic activities of cardiac fibroblasts.
    Journal of cardiovascular pharmacology and therapeutics, 2013, Volume: 18, Issue:5

    Topics: Animals; Disease Models, Animal; Fibroblasts; Fibrosis; Imaging, Three-Dimensional; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocardial Infarction; Myocardial Reperfusion Injury; Phosphorylation; Pyrroles; Quinazolines; Rats; Rats, Sprague-Dawley; Receptor, PAR-1; Transforming Growth Factor beta; Ventricular Remodeling

2013
Differential Inhibition of the TGF-β Signaling Pathway in HCC Cells Using the Small Molecule Inhibitor LY2157299 and the D10 Monoclonal Antibody against TGF-β Receptor Type II.
    PloS one, 2013, Volume: 8, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Carcinoma, Hepatocellular; Connective Tissue Growth Factor; Female; Hep G2 Cells; Homeodomain Proteins; Humans; Liver Neoplasms; Male; Middle Aged; Protein Serine-Threonine Kinases; Pyrazoles; Pyrroles; Quinolines; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Signal Transduction; Smad2 Protein; Transcription Factors; Transforming Growth Factor beta; Vascular Endothelial Growth Factor A

2013
Endothelial injury in a transforming growth factor β-dependent mouse model of scleroderma induces pulmonary arterial hypertension.
    Arthritis and rheumatism, 2013, Volume: 65, Issue:11

    Topics: Angiogenesis Inhibitors; Animals; Disease Models, Animal; Endothelium, Vascular; Familial Primary Pulmonary Hypertension; Female; Hypertension, Pulmonary; Hypoxia; Indoles; Lac Operon; Male; Mice; Mice, Transgenic; Phenotype; Protein Serine-Threonine Kinases; Pulmonary Circulation; Pyrroles; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Receptors, Vascular Endothelial Growth Factor; Scleroderma, Systemic; Signal Transduction; Transforming Growth Factor beta

2013
CD4+CD25+ T regs with acetylated FoxP3 are associated with immune suppression in human leprosy.
    Molecular immunology, 2013, Volume: 56, Issue:4

    Topics: Acetylation; Active Transport, Cell Nucleus; Adolescent; Adult; CD4-Positive T-Lymphocytes; Cell Nucleus; Cyclosporine; Female; Forkhead Transcription Factors; Humans; Immunosuppressive Agents; Interleukin-2; Interleukin-2 Receptor alpha Subunit; Isoquinolines; Leprosy; Leukocyte Common Antigens; Male; Middle Aged; NFATC Transcription Factors; Phosphorylation; Pyridines; Pyrroles; Smad3 Protein; T-Lymphocytes, Regulatory; Transforming Growth Factor beta; Ubiquitination; Young Adult

2013
Vascular endothelial growth factor receptor inhibitor SU5416 suppresses lymphocyte generation and immune responses in mice by increasing plasma corticosterone.
    PloS one, 2013, Volume: 8, Issue:9

    Topics: Animals; Corticosterone; Immunity, Active; Indoles; Lymphocytes; Mice; Mice, Inbred C57BL; Pyrroles; Receptors, Vascular Endothelial Growth Factor; Transforming Growth Factor beta

2013
Protein kinase inhibitor SU6668 attenuates positive regulation of Gli proteins in cancer and multipotent progenitor cells.
    Biochimica et biophysica acta, 2014, Volume: 1843, Issue:4

    Topics: Animals; Cell Differentiation; Cells, Cultured; Gene Expression Regulation, Developmental; Hedgehog Proteins; Humans; Indoles; Kruppel-Like Transcription Factors; Leukocytes, Mononuclear; Mice; Multipotent Stem Cells; Neoplasms; Nuclear Proteins; Oxindoles; Propionates; Protein Serine-Threonine Kinases; Pyrroles; Signal Transduction; Transcription Factors; Transforming Growth Factor beta; Zinc Finger Protein GLI1; Zinc Finger Protein Gli2

2014
Ellagic acid exerts anti-proliferation effects via modulation of Tgf-β/Smad3 signaling in MCF-7 breast cancer cells.
    Asian Pacific journal of cancer prevention : APJCP, 2014, Volume: 15, Issue:1

    Topics: Antineoplastic Agents; Cell Cycle Checkpoints; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Ellagic Acid; Gene Expression; Humans; Isoquinolines; MCF-7 Cells; Pyridines; Pyrroles; Retinoblastoma Protein; Signal Transduction; Smad3 Protein; Transforming Growth Factor beta

2014
JARID1B is a luminal lineage-driving oncogene in breast cancer.
    Cancer cell, 2014, Jun-16, Volume: 25, Issue:6

    Topics: Breast Neoplasms; CCCTC-Binding Factor; Cell Growth Processes; Cell Line, Tumor; Cell Lineage; Female; Gene Amplification; Gene Expression Regulation, Neoplastic; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; MCF-7 Cells; Mutation; Nuclear Proteins; Oncogenes; Promoter Regions, Genetic; Pyrazoles; Pyrroles; Repressor Proteins; RNA, Small Interfering; Transfection; Transforming Growth Factor beta

2014
The microRNA 424/503 cluster reduces CDC25A expression during cell cycle arrest imposed by transforming growth factor β in mammary epithelial cells.
    Molecular and cellular biology, 2014, Dec-01, Volume: 34, Issue:23

    Topics: Animals; Apoptosis; cdc25 Phosphatases; Cell Line; Cell Proliferation; Down-Regulation; Epithelial Cells; Female; G1 Phase Cell Cycle Checkpoints; Humans; Insulin-Like Growth Factor I; Mammary Glands, Animal; Mammary Glands, Human; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; MicroRNAs; Promoter Regions, Genetic; Pyrazoles; Pyrroles; Receptors, Estrogen; Receptors, Progesterone; Transcription, Genetic; Transforming Growth Factor beta

2014
Galangin suppresses HepG2 cell proliferation by activating the TGF-β receptor/Smad pathway.
    Toxicology, 2014, Dec-04, Volume: 326

    Topics: Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Carcinoma, Hepatocellular; Cell Proliferation; Dose-Response Relationship, Drug; Flavonoids; Hep G2 Cells; Humans; Liver Neoplasms; Protein Serine-Threonine Kinases; Pyrazoles; Pyrroles; Receptor, Transforming Growth Factor-beta Type I; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; RNA Interference; Signal Transduction; Smad Proteins; Transfection; Transforming Growth Factor beta

2014
Metformin enhances the anti-adipogenic effects of atorvastatin via modulation of STAT3 and TGF-β/Smad3 signaling.
    Biochemical and biophysical research communications, 2015, Jan-02, Volume: 456, Issue:1

    Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Animals; Atorvastatin; Cell Differentiation; Cell Survival; Cyclin D1; Heptanoic Acids; Homeostasis; Hypoglycemic Agents; Kruppel-Like Transcription Factors; Metformin; Mice; Pyrroles; Signal Transduction; Smad3 Protein; Smad7 Protein; STAT3 Transcription Factor; Transforming Growth Factor beta; Tumor Suppressor Protein p53

2015
Inhibition of TGFβ type I receptor activity facilitates liver regeneration upon acute CCl4 intoxication in mice.
    Archives of toxicology, 2016, Volume: 90, Issue:2

    Topics: Animals; Biomarkers; Carbon Tetrachloride Poisoning; Hepatic Stellate Cells; Hepatocytes; Liver; Liver Regeneration; Male; Mice, Inbred C57BL; Protein Serine-Threonine Kinases; Pyrazoles; Pyrroles; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Signal Transduction; Transforming Growth Factor beta

2016
The Suppression of Wound Healing Response with Sirolimus and Sunitinib Following Experimental Trabeculectomy in a Rabbit Model.
    Current eye research, 2016, Volume: 41, Issue:3

    Topics: Alkylating Agents; Angiogenesis Inhibitors; Animals; Disease Models, Animal; Fibroblast Growth Factor 2; Fibroblast Growth Factors; Immunosuppressive Agents; Indoles; Male; Mitomycin; Platelet-Derived Growth Factor; Pyrroles; Rabbits; Sirolimus; Sunitinib; Trabecular Meshwork; Trabeculectomy; Transforming Growth Factor beta; Wound Healing

2016
Pirfenidone enhances the efficacy of combined radiation and sunitinib therapy.
    Biochemical and biophysical research communications, 2015, Jun-26, Volume: 462, Issue:2

    Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Lewis Lung; Cell Line, Tumor; Collagen; Combined Modality Therapy; Indoles; Mice; Microvessels; Pyridones; Pyrroles; Radiation Tolerance; Sunitinib; Transforming Growth Factor beta; Vascular Endothelial Growth Factor A

2015
HIF-1 Dimerization Inhibitor Acriflavine Enhances Antitumor Activity of Sunitinib in Breast Cancer Model.
    Oncology research, 2014, Volume: 22, Issue:3

    Topics: Acriflavine; Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Disease Models, Animal; Drug Synergism; Female; Hypoxia-Inducible Factor 1; Indoles; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Myeloid Cells; Necrosis; Neovascularization, Pathologic; Protein Multimerization; Pyrroles; Spleen; Sunitinib; Transforming Growth Factor beta; Vascular Endothelial Growth Factor A

2014
LY2109761 enhances cisplatin antitumor activity in ovarian cancer cells.
    International journal of clinical and experimental pathology, 2015, Volume: 8, Issue:5

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Ovarian Epithelial; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cisplatin; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Female; Humans; Mice, Inbred ICR; Mice, SCID; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Phosphorylation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrazoles; Pyrroles; Receptor, Transforming Growth Factor-beta Type I; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Signal Transduction; Smad2 Protein; Time Factors; Transforming Growth Factor beta; Tumor Burden; Xenograft Model Antitumor Assays

2015
miR-221/222 Are Involved in Response to Sunitinib Treatment in Metastatic Renal Cell Carcinoma.
    Molecular therapy : the journal of the American Society of Gene Therapy, 2015, Volume: 23, Issue:11

    Topics: Angiogenesis Inhibitors; Animals; Biomarkers, Pharmacological; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Proliferation; Disease-Free Survival; Human Umbilical Vein Endothelial Cells; Humans; Indoles; Kidney Neoplasms; MicroRNAs; Middle Aged; Models, Statistical; Neovascularization, Pathologic; Prognosis; Pyrroles; Signal Transduction; Sunitinib; TOR Serine-Threonine Kinases; Transforming Growth Factor beta; Treatment Outcome; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2

2015
Cytoskeletal Reorganization Drives Mesenchymal Condensation and Regulates Downstream Molecular Signaling.
    PloS one, 2015, Volume: 10, Issue:8

    Topics: Actins; Animals; Bone Morphogenetic Proteins; Cell Shape; Cells, Cultured; Chick Embryo; Chondrocytes; Chondrogenesis; Cytochalasin D; Cytoskeleton; Fibroblast Growth Factors; Heterocyclic Compounds, 4 or More Rings; Pyrazoles; Pyrimidines; Pyrroles; Signal Transduction; Transforming Growth Factor beta

2015
Reduction of Dimethylnitrosamine-Induced Liver Fibrosis by the Novel Gene Regulator PI Polyamide Targeting Transforming Growth Factor β1 Gene.
    Biological & pharmaceutical bulletin, 2015, Volume: 38, Issue:12

    Topics: Actins; Animals; Cell Line; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; End Stage Liver Disease; Fibrosis; Gene Silencing; Hepatic Stellate Cells; Imidazoles; Liver; Liver Cirrhosis; Liver Cirrhosis, Experimental; Male; Matrix Metalloproteinase 2; Pyrroles; Rats, Sprague-Dawley; RNA, Messenger; Transforming Growth Factor beta

2015
Halting pro-survival autophagy by TGFβ inhibition in bone marrow fibroblasts overcomes bortezomib resistance in multiple myeloma patients.
    Leukemia, 2016, Volume: 30, Issue:3

    Topics: Aged; Aged, 80 and over; Animals; Antineoplastic Agents; Autophagy; Bone Marrow Cells; Bortezomib; Drug Combinations; Drug Resistance, Neoplasm; Female; Fibroblasts; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; Microtubule-Associated Proteins; Middle Aged; Multiple Myeloma; Plasma Cells; Primary Cell Culture; Pyrazoles; Pyrroles; RNA-Binding Proteins; Signal Transduction; Survival Analysis; TOR Serine-Threonine Kinases; Transforming Growth Factor beta; Xenograft Model Antitumor Assays

2016
Yap1 promotes the survival and self-renewal of breast tumor initiating cells via inhibiting Smad3 signaling.
    Oncotarget, 2016, Mar-01, Volume: 7, Issue:9

    Topics: Adaptor Proteins, Signal Transducing; Animals; Breast Neoplasms; Cell Cycle Proteins; Estrogen Receptor alpha; Female; Humans; Isoquinolines; Mammary Neoplasms, Experimental; Mammary Tumor Virus, Mouse; Mice; Mice, Knockout; Neoplastic Stem Cells; Phosphoproteins; Phosphorylation; Pyridines; Pyrroles; Smad3 Protein; Transcription Factors; Transforming Growth Factor beta; Wnt1 Protein; YAP-Signaling Proteins

2016
[Sunitinib suppresses migration of ovarian cancer cells through negative modulation of TGF-β-mediated epithelial-mesenchymal transition].
    Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2015, Volume: 44, Issue:5

    Topics: Antigens, CD; Cadherins; Cell Line, Tumor; Cell Movement; Down-Regulation; Epithelial-Mesenchymal Transition; Female; Humans; Indoles; Ovarian Neoplasms; Pyrroles; Smad Proteins; Snail Family Transcription Factors; Sunitinib; Transcription Factors; Transforming Growth Factor beta; Up-Regulation

2015
Promoting tumor penetration of nanoparticles for cancer stem cell therapy by TGF-β signaling pathway inhibition.
    Biomaterials, 2016, Volume: 82

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Humans; Nanocapsules; Neoplastic Stem Cells; Protein Serine-Threonine Kinases; Pyrazoles; Pyrroles; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; RNA, Small Interfering; Signal Transduction; Transforming Growth Factor beta; Treatment Outcome

2016
The TGFβ pathway stimulates ovarian cancer cell proliferation by increasing IGF1R levels.
    International journal of cancer, 2016, 10-15, Volume: 139, Issue:8

    Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Carcinoma, Ovarian Epithelial; Cell Proliferation; Female; Heterografts; Humans; Mice; Mice, Nude; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Pyrazoles; Pyrroles; Random Allocation; Receptor, IGF Type 1; Receptors, Somatomedin; Signal Transduction; Transforming Growth Factor beta

2016
Heat shock protein 22 (HSPB8) limits TGF-β-stimulated migration of osteoblasts.
    Molecular and cellular endocrinology, 2016, 11-15, Volume: 436

    Topics: Animals; Animals, Newborn; Cell Line; Cell Movement; Gene Knockdown Techniques; Heat-Shock Proteins; HSP20 Heat-Shock Proteins; HSP27 Heat-Shock Proteins; Isoquinolines; Mice; Molecular Chaperones; Muscle Proteins; Osteoblasts; Phosphorylation; Protein Binding; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyridines; Pyrroles; Receptor, Transforming Growth Factor-beta Type I; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; RNA, Messenger; RNA, Small Interfering; Smad Proteins; Transforming Growth Factor beta

2016
Sunitinib, a Small-Molecule Kinase Inhibitor, Attenuates Bleomycin-Induced Pulmonary Fibrosis in Mice.
    The Tohoku journal of experimental medicine, 2016, Volume: 239, Issue:4

    Topics: Animals; Bleomycin; Bronchi; Cell Proliferation; Disease Models, Animal; Epithelial Cells; Extracellular Matrix; Female; Fibroblasts; Humans; Indoles; Mesoderm; Mice; Mice, Inbred C57BL; Phosphorylation; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Pulmonary Fibrosis; Pyrroles; Signal Transduction; Smad Proteins; Small Molecule Libraries; Sunitinib; Transforming Growth Factor beta; Vascular Endothelial Growth Factor A

2016
C-reactive protein promotes acute kidney injury via Smad3-dependent inhibition of CDK2/cyclin E.
    Kidney international, 2016, Volume: 90, Issue:3

    Topics: Acute Kidney Injury; Animals; C-Reactive Protein; Cell Line, Tumor; Cell Proliferation; Creatinine; Cyclin E; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p27; Disease Models, Animal; Epithelial Cells; G1 Phase Cell Cycle Checkpoints; Humans; Isoquinolines; Kidney Tubules; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mice, Knockout; Necrosis; Phosphorylation; Pyridines; Pyrroles; Rats; Receptors, IgG; Regeneration; Smad3 Protein; Transforming Growth Factor beta

2016
HSP47 Promotes Glioblastoma Stemlike Cell Survival by Modulating Tumor Microenvironment Extracellular Matrix through TGF-β Pathway.
    ACS chemical neuroscience, 2017, 01-18, Volume: 8, Issue:1

    Topics: Analysis of Variance; Animals; Brain Neoplasms; Cell Survival; Computational Biology; Disease Models, Animal; Extracellular Matrix; Flow Cytometry; Gene Expression Regulation, Neoplastic; Glioblastoma; HSP47 Heat-Shock Proteins; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplastic Stem Cells; Platelet Endothelial Cell Adhesion Molecule-1; Pyrazoles; Pyrroles; RNA, Messenger; Transforming Growth Factor beta; Tumor Cells, Cultured; Tumor Microenvironment; Xenograft Model Antitumor Assays

2017
Degenerative Suspensory Ligament Desmitis (DSLD) in Peruvian Paso Horses Is Characterized by Altered Expression of TGFβ Signaling Components in Adipose-Derived Stromal Fibroblasts.
    PloS one, 2016, Volume: 11, Issue:11

    Topics: Adipose Tissue; Animals; Chromatin; Fibroblasts; Gene Expression Regulation; Horse Diseases; Horses; Ligaments; Male; Protein Serine-Threonine Kinases; Pyrazoles; Pyrroles; Receptor, Transforming Growth Factor-beta Type I; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Signal Transduction; Stromal Cells; Transforming Growth Factor beta; Transforming Growth Factor beta1

2016
CD61 promotes the differentiation of canine ADMSCs into PGC-like cells through modulation of TGF-β signaling.
    Scientific reports, 2017, 03-03, Volume: 7

    Topics: Adipose Tissue; Animals; Cell Differentiation; Cells, Cultured; Dogs; Gene Expression; Germ Cells; Integrin beta3; Male; Mesenchymal Stem Cells; Phosphorylation; Pyrazoles; Pyrroles; Signal Transduction; Smad2 Protein; Transforming Growth Factor beta

2017
Transforming growth factor β-inhibitor Repsox downregulates collagen expression of scleroderma dermal fibroblasts and prevents bleomycin-induced mice skin fibrosis.
    Experimental dermatology, 2017, Volume: 26, Issue:11

    Topics: Actins; Amino Acids; Aminopyridines; Animals; Bleomycin; Collagen Type I; Collagen Type I, alpha 1 Chain; Connective Tissue Growth Factor; Fibroblasts; Fibrosis; Humans; Inhibitory Concentration 50; Mice; Phenols; Pyrazoles; Pyridines; Pyrroles; Scleroderma, Systemic; Signal Transduction; Skin; Transforming Growth Factor beta; Up-Regulation; Xanthenes

2017
Negative control of the HGF/c-MET pathway by TGF-β: a new look at the regulation of stemness in glioblastoma.
    Cell death & disease, 2017, 12-13, Volume: 8, Issue:12

    Topics: Antineoplastic Agents; Butadienes; Cell Line, Tumor; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Glioblastoma; Hepatocyte Growth Factor; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neoplastic Stem Cells; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-met; Pteridines; Pyrazoles; Pyridazines; Pyrimidines; Pyrroles; Quinolines; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Signal Transduction; Transforming Growth Factor beta

2017
Pentachloropseudilin Inhibits Transforming Growth Factor-β (TGF-β) Activity by Accelerating Cell-Surface Type II TGF-β Receptor Turnover in Target Cells.
    Chembiochem : a European journal of chemical biology, 2018, 04-16, Volume: 19, Issue:8

    Topics: Animals; Cell Line; Epithelial-Mesenchymal Transition; Extracellular Matrix; Humans; Hydrocarbons, Chlorinated; Myosin Type I; Pyrroles; Receptor, Transforming Growth Factor-beta Type II; Smad Proteins; Transforming Growth Factor beta

2018
Specific Inhibitor of Smad3 (SIS3) Attenuates Fibrosis, Apoptosis, and Inflammation in Unilateral Ureteral Obstruction Kidneys by Inhibition of Transforming Growth Factor β (TGF-β)/Smad3 Signaling.
    Medical science monitor : international medical journal of experimental and clinical research, 2018, Mar-20, Volume: 24

    Topics: Animals; Apoptosis; Fibrosis; Inflammation; Isoquinolines; Kidney; Male; Mice, Inbred BALB C; Myofibroblasts; Pyridines; Pyrroles; Signal Transduction; Smad3 Protein; Transforming Growth Factor beta; Ureteral Obstruction

2018
Pentabromopseudilin: a myosin V inhibitor suppresses TGF-β activity by recruiting the type II TGF-β receptor to lysosomal degradation.
    Journal of enzyme inhibition and medicinal chemistry, 2018, Volume: 33, Issue:1

    Topics: Alteromonas; Animals; Cell Line; Dose-Response Relationship, Drug; HEK293 Cells; Hep G2 Cells; Humans; Lysosomes; Mink; Molecular Structure; Myosin Type V; Protein Serine-Threonine Kinases; Pseudomonas; Pyrroles; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Structure-Activity Relationship; Transforming Growth Factor beta

2018
The preventive and therapeutic implication for renal fibrosis by targetting TGF-β/Smad3 signaling.
    Clinical science (London, England : 1979), 2018, 07-16, Volume: 132, Issue:13

    Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Fibrosis; Isoquinolines; Kidney; Male; Mice, Inbred C57BL; Pyridines; Pyrroles; Signal Transduction; Smad3 Protein; Transforming Growth Factor beta; Ureteral Obstruction

2018
In vitro and ex vivo anti-fibrotic effects of LY2109761, a small molecule inhibitor against TGF-β.
    Toxicology and applied pharmacology, 2018, 09-15, Volume: 355

    Topics: Adenosine Triphosphate; Animals; Cell Line; Collagen Type I; Down-Regulation; Fibrosis; Gene Expression; Humans; In Vitro Techniques; Liver; Male; Phosphorylation; Pyrazoles; Pyrroles; Rats; Rats, Wistar; Smad1 Protein; Smad2 Protein; Tissue Inhibitor of Metalloproteinase-2; Transforming Growth Factor beta

2018
TGF-β/Smads Signaling Affects Radiation Response and Prolongs Survival by Regulating DNA Repair Genes in Malignant Glioma.
    DNA and cell biology, 2018, Volume: 37, Issue:11

    Topics: Acid Anhydride Hydrolases; Animals; ATP-Binding Cassette Transporters; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; DNA Damage; DNA Glycosylases; DNA Modification Methylases; DNA Repair; DNA Repair Enzymes; DNA-Binding Proteins; Gamma Rays; Gene Expression Regulation, Neoplastic; Glioma; Humans; Mice; MutL Protein Homolog 1; MutS Homolog 2 Protein; Neuroglia; Pyrazoles; Pyrroles; RNA, Small Interfering; Signal Transduction; Smad Proteins; Survival Analysis; Transforming Growth Factor beta; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays

2018
Knockdown of KDM2A inhibits proliferation associated with TGF-β expression in HEK293T cell.
    Molecular and cellular biochemistry, 2019, Volume: 456, Issue:1-2

    Topics: Cell Proliferation; CRISPR-Cas Systems; F-Box Proteins; Gene Knockdown Techniques; HEK293 Cells; Humans; Jumonji Domain-Containing Histone Demethylases; Pyrazoles; Pyrroles; Transforming Growth Factor beta

2019
Injury-Induced Shedding of Extracellular Vesicles Depletes Endothelial Cells of Cav-1 (Caveolin-1) and Enables TGF-β (Transforming Growth Factor-β)-Dependent Pulmonary Arterial Hypertension.
    Arteriosclerosis, thrombosis, and vascular biology, 2019, Volume: 39, Issue:6

    Topics: Adolescent; Adult; Aged; Animals; Bone Morphogenetic Protein Receptors, Type II; Case-Control Studies; Caveolin 1; Cell Proliferation; Disease Models, Animal; Endothelial Cells; Extracellular Vesicles; Female; Humans; Hypoxia; Indoles; Male; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Nitric Oxide Synthase Type III; Pulmonary Arterial Hypertension; Pyrroles; Rats, Sprague-Dawley; Signal Transduction; Smad Proteins; Transforming Growth Factor beta; Vascular Remodeling; Young Adult

2019
Cathelicidin-related antimicrobial peptide protects against cardiac fibrosis in diabetic mice heart by regulating endothelial-mesenchymal transition.
    International journal of biological sciences, 2019, Volume: 15, Issue:11

    Topics: AMP-Activated Protein Kinases; Animals; Antimicrobial Cationic Peptides; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Echocardiography; Endothelial Cells; Endothelium; Epithelial-Mesenchymal Transition; Fibrosis; Glucose; Hemodynamics; Hyperglycemia; Male; Mice; Mice, Inbred C57BL; Pyrazoles; Pyrroles; Signal Transduction; Transforming Growth Factor beta

2019
TGF-β receptor inhibitor LY2109761 enhances the radiosensitivity of gastric cancer by inactivating the TGF-β/SMAD4 signaling pathway.
    Aging, 2019, 10-19, Volume: 11, Issue:20

    Topics: Animals; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Humans; Male; Mice, Nude; Neoplasms, Experimental; Pyrazoles; Pyrroles; Radiation Tolerance; Signal Transduction; Smad4 Protein; Stomach Neoplasms; Transforming Growth Factor beta

2019
A novel approach for monitoring TGF-β signaling in vivo in colon cancer.
    Carcinogenesis, 2021, 04-30, Volume: 42, Issue:4

    Topics: Animals; Benzamides; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Dioxoles; Disease Models, Animal; Humans; Mice; Protein Kinase Inhibitors; Pyrazoles; Pyrroles; Receptors, Transforming Growth Factor beta; Signal Transduction; Transforming Growth Factor beta

2021
Moderate oxidative stress promotes epithelial-mesenchymal transition in the lens epithelial cells via the TGF-β/Smad and Wnt/β-catenin pathways.
    Molecular and cellular biochemistry, 2021, Volume: 476, Issue:3

    Topics: Animals; Antioxidants; beta Catenin; Capsule Opacification; Cataract; Cell Proliferation; Cell Survival; Disease Models, Animal; Epithelial Cells; Epithelial-Mesenchymal Transition; Fibrosis; Humans; Lens, Crystalline; Mice; Oxidative Stress; Oxygen; Pyrazoles; Pyrroles; Swine; Transforming Growth Factor beta; Transforming Growth Factor beta1; Tropicamide; Wnt Signaling Pathway

2021
Bone marrow mesenchymal stem cells in microenvironment transform into cancer-associated fibroblasts to promote the progression of B-cell acute lymphoblastic leukemia.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020, Volume: 130

    Topics: Benzylamines; Cancer-Associated Fibroblasts; Cell Line, Tumor; Chemokine CXCL12; Cyclams; Disease Progression; Humans; Mesenchymal Stem Cells; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Pyrazoles; Pyrroles; Receptors, CXCR4; Signal Transduction; Transforming Growth Factor beta; Tumor Microenvironment

2020
The local wound environment is a key determinant of the outcome of TGFβ signaling on the fibrotic response of CD44
    Experimental eye research, 2021, Volume: 213

    Topics: Actins; Animals; Blotting, Western; Capsule Opacification; Cataract Extraction; Cell Proliferation; Chick Embryo; Collagen Type I; Disease Models, Animal; Fibronectins; Fibrosis; Hyaluronan Receptors; Imidazoles; Integrin alphaVbeta3; Microscopy, Fluorescence; Myofibroblasts; Posterior Capsule of the Lens; Postoperative Complications; Pyrazoles; Pyrroles; Quinoxalines; Receptor, Transforming Growth Factor-beta Type I; Signal Transduction; Transforming Growth Factor beta; Wound Healing

2021
TGF-β-Induced FLRT3 Attenuation Is Essential for Cancer-Associated Fibroblast-Mediated Epithelial-Mesenchymal Transition in Colorectal Cancer.
    Molecular cancer research : MCR, 2022, 08-05, Volume: 20, Issue:8

    Topics: Antigens, CD; Cadherins; Cancer-Associated Fibroblasts; Cell Line, Tumor; Cell Movement; Colorectal Neoplasms; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Humans; Membrane Glycoproteins; Pyrazoles; Pyrroles; Signal Transduction; Transforming Growth Factor beta; Tumor Microenvironment

2022
Self-carried nanodrug (SCND-SIS3): A targeted therapy for lung cancer with superior biocompatibility and immune boosting effects.
    Biomaterials, 2022, Volume: 288

    Topics: Animals; Carcinoma; Cell Line, Tumor; Isoquinolines; Lung Neoplasms; Mice; Nanoparticles; Pyridines; Pyrroles; Signal Transduction; Smad3 Protein; Transforming Growth Factor beta

2022