pyrroles has been researched along with thiazoles in 186 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (7.53) | 18.7374 |
| 1990's | 30 (16.13) | 18.2507 |
| 2000's | 46 (24.73) | 29.6817 |
| 2010's | 86 (46.24) | 24.3611 |
| 2020's | 10 (5.38) | 2.80 |
| Authors | Studies |
|---|---|
| Hayashi, M; Iguchi, Y; Iizuka, K; Kajiwara, I; Kawamura, M; Miyamoto, T; Nakazawa, M; Ohyama, I; Okada, T; Taniguchi, K; Tanouchi, T | 1 |
| Fotsch, C; St Jean, DJ | 1 |
| Rockwell, S | 1 |
| Bryan, GT; Muraoka, K; Wang, CY | 1 |
| Adnet, F; Liquier, J; Lown, JW; Rao, KE; Singh, MP; Taillandier, E | 1 |
| Leidig, A; Nebel, U; Peters, T; Wermelskirchen, D; Wilffert, B; Wirth, A | 1 |
| Berridge, MV; Tan, AS | 1 |
| Awata, N; Nakada, Y; Shimada, H | 1 |
| Akimoto, K; Hanamori, M; Mizuno, T; Nakagawa, H | 1 |
| Nebel, U; Peters, T; Wermelskirchen, D; Wilffert, B; Wirth, A | 1 |
| Awata, N; Ikuta, Y; Kawashima, T; Nakada, Y | 1 |
| Ager, IR; Barnes, AC; Danswan, GW; Hairsine, PW; Kay, DP; Kennewell, PD; Matharu, SS; Miller, P; Robson, P; Rowlands, DA | 1 |
| Lalezari, I; Schwartz, EL | 1 |
| Burgemeister, T; Dannhardt, G; Graf, E; Obergrusberger, R | 1 |
| Katz, N; Pellegrino, J | 1 |
| Berk, S; Gisser, H | 1 |
| Goldschmidt, MC; Williams, RP | 1 |
| Aviado, DM | 1 |
| Elion, GB; Hitchings, GH; Krenitsky, TA; Neil, SM | 1 |
| Achtari, H; Goldenberg, B; Revaz, C | 1 |
| Dunoff, RY; Graboyes, H; Jaffe, G; Karash, CB; Pachter, IJ; Snader, K; Weinstock, J | 1 |
| McKenzie, S; Molloy, BB; Reid, DH | 1 |
| Obata, Y; Oda, M; Yamamoto, N; Yokota, K | 2 |
| Bian, SS; Chen, YL; Lee, H | 1 |
| Oda, M; Yamashita, A; Yokota, K | 1 |
| Chimirri, A; Grasso, S; Monforte, AM; Monforte, P; Zappalà, M | 1 |
| Biava, M; Fioravanti, R; Frachey, G; Mencarelli, P; Perazzi, ME; Porretta, GC; Simonetti, N; Sleiter, G; Villa, A | 1 |
| Oda, M; Yamamoto, N; Yamashita, A; Yokota, K | 2 |
| Carstam, R; Hindemith, A; Odh, G; Paulson, J; Rorsman, H; Rosengren, E | 1 |
| Huxtable, RJ; Yan, CC | 1 |
| Christensen, BG; Hatsushiba, E; Ohuchi, S; Okonogi, T; Patchett, AA; Shibahara, S; Tsutsumi, S | 1 |
| Cuevas, AA; García-Castiñeiras, S | 1 |
| Kato, S; Matsuoka, M; Mochizuki, J; Odagawa, A; Shindo, K; Yamagishi, Y | 1 |
| Kawai, H; Shindo, K; Yamagishi, Y | 1 |
| Morimoto, Y; Oda, M; Yamamoto, N; Yamashita, A; Yokota, K | 1 |
| Oda, M; Yamamoto, N; Yamashita, A; Yokota, K; Yoshidomi, M | 1 |
| Matsuo, K; Oda, M; Yamashita, A; Yokota, K | 1 |
| Kondo, K; Nakashima, M; Shimazawa, M; Takiguchi, Y; Umemura, K | 1 |
| Sternon, J | 1 |
| Aicher, TD; Balkan, B; Bell, PA; Brand, LJ; Cheon, SH; Deems, RO; Fell, JB; Fillers, WS; Fraser, JD; Gao, J; Kahle, GG; Knorr, DC; Leone, CL; Nadelson, J; Simpson, R; Smith, HC | 1 |
| Althaus, JS; Fici, GJ; VonVoigtlander, PF | 1 |
| Défago, G; Duffy, BK | 1 |
| Chaki, S; Kawashima, N; Okuyama, S; Omura, T; Tomisawa, K | 1 |
| Currier, JS | 1 |
| Lown, JW; Sharma, SK; Tandon, M | 1 |
| Li, P; Xu, JC | 1 |
| DiTusa, L; Luzier, AB | 1 |
| Demuth, H; Mrestani-Klaus, C; Neubert, K; Stiebitz, B; Stöckel-Maschek, A | 1 |
| Adzet, T; Alegret, M; Cabrero, A; Laguna, JC; Sánchez, RM; Vázquez, M | 1 |
| Akuzawa, S; Ito, H; Iwaoka, K; Kamato, T; Kiso, T; Miyata, K; Nagakura, Y; Naitoh, Y; Sakai, H; Suzuki, M; Yamaguchi, T; Yamano, M; Yuki, H | 1 |
| Deutch, CE; Klarstrom, JL; Link, CL; Ricciardi, DL | 1 |
| Ito, H; Iwaoka, K; Kiso, T; Miyata, K; Naitoh, Y; Yamaguchi, T; Yuki, H | 1 |
| Ito, H; Iwaoka, K; Kamato, T; Kiso, T; Miyata, K; Naitoh, Y; Yamaguchi, T | 1 |
| Dalvie, DK; Kalgutkar, AS; Khojasteh-Bakht, SC; O'Donnell, JP; Obach, RS | 1 |
| Abourjaily, HM; Alsheikh-Ali, AA; Karas, RH | 1 |
| Ito, H; Iwaoka, K; Kiso, T; Miyata, K; Nagakura, Y; Yamaguchi, T | 1 |
| Lee, KG; Ochi, H; Shibamoto, T; Yanagimoto, K | 1 |
| Kumazawa, K; Masuda, H | 1 |
| Biswas, N; Brunzell, JD; Cohen, BR; Freed, MI; Kreider, MM; Marcovina, SM; Ratner, R | 1 |
| Demopoulos, VJ; Nicolaou, I; Zaher, N | 1 |
| Almeida, A; Bolanos, JP; Dello Russo, C; Feinstein, DL; Galea, E; Gavrilyuk, V; Palmer, J; Pelligrino, D; Weinberg, G | 1 |
| Allione, A; Beltramo, E; Buttiglieri, S; D'Alù, F; Lacaria, A; Pomero, F; Ponte, E; Porta, M | 1 |
| Chen, Y; Depinto, W; Dermatakis, A; Kammlott, U; Konzelmann, F; Liu, JJ; Luk, KC; Lukacs, C; Schutt, A; Simcox, ME; Yang, H; Yin, X | 1 |
| Fujikawa, K; Ito, S; Wakamatsu, K; Zecca, L; Zucca, FA | 1 |
| Cao, C; Cho, KW; Han, JH; Kim, SH; Kim, SZ | 1 |
| Anthony, NG; Johnston, BF; Khalaf, AI; MacKay, SP; Parkinson, JA; Suckling, CJ; Waigh, RD | 1 |
| Jiang, BH; Reed, E; Zheng, JZ; Zhong, XS | 1 |
| Petruso, S; Schillaci, D; Sciortino, V | 1 |
| Koelsch, R; Neubert, K; Stiebitz, B; Stöckel-Maschek, A | 1 |
| Crisby, M; Lindberg, C; Schultzberg, M; Winblad, B | 1 |
| Berezin, VA; Bock, E; Dmitrieva, O; Klementiev, B; Lushnikova, IV; Novikova, T; Skibo, GG; Vaudano, E; Voronin, KY | 1 |
| Baron, O; Ila, H; Knochel, P; Wagner, AJ | 1 |
| Akahoshi, F; Hayashi, Y; Kitajima, H; Sakashita, H; Tsutsumiuchi, R | 1 |
| Fausto, R; Kaczor, A; Pinho e Melo, TM; Soares, MI | 1 |
| Adams, A; De Kimpe, N | 1 |
| Curtiss, FR | 1 |
| von Mehren, M | 1 |
| Chander, R; Deorukhkar, AA; Pandey, R; Sainis, KB | 1 |
| Haura, EB; Li, J; Viallet, J | 1 |
| Arora, DK; Saikia, R; Singh, BP; Varghese, S | 1 |
| Berry, CR; Gibbs, AC; Hlasta, DJ; Zificsak, CA | 1 |
| Thomas, X | 1 |
| Faivre, S; Le Tourneau, C; Raymond, E | 1 |
| Bui, B; Italiano, A | 1 |
| Ariga, H; Iguchi-Ariga, S; Miyazaki, S; Nakano, M; Nunome, K | 1 |
| Dykens, JA; Hirakawa, B; Hynes, J; Jamieson, J; Jessen, BA; Marroquin, LD; Nadanaciva, S; Patyna, S; Will, Y | 1 |
| Decosterd, LA; Duchosal, MA; Haouala, A; Leyvraz, S; Montemurro, M; Ris, HB; Rochat, B; Widmer, N; Zaman, K; Zanolari, B | 1 |
| Boeck, CR; Carqueja, CL; Dal'agnolo, D; de Araújo Herculano, B; Martins, WC; Piermartiri, TC; Stroeh, E; Tasca, CI; Vandresen-Filho, S | 1 |
| Gelderblom, H; Guchelaar, HJ; van Erp, NP | 1 |
| Bala, BD; Karthikeyan, SV; Perumal, S; Raja, VP; Sriram, D; Yogeeswari, P | 1 |
| Arduini, RM; Baker, DP; Cullen, PF; Hession, CA; Hong, V; Hopkins, BT; Jenkins, TJ; Liu, YT; Marcotte, DJ; Mertsching, E; Miatkowski, K; Romanowski, MJ; Silvian, LF; Wildes, CP | 1 |
| Ashman, LK; Griffith, R; Mashkani, B | 1 |
| Bonvalot, S; Cioffi, A; Dômont, J; Le Cesne, A; Tardieu, M | 1 |
| Colombo, M; Mazzoleni, M; Saliu, F; Tremolada, P; Vighi, M | 1 |
| Jane, EP; Pollack, IF; Premkumar, DR | 1 |
| Vollmar, AM; von Schwarzenberg, K | 1 |
| Agostino, NM; Chinchilli, VM; Drabick, JJ; Gingrich, R; Koszyk-Szewczyk, A; Lynch, CJ; Sivik, J | 1 |
| Abrantes, AM; Beja, AM; Botelho, MF; Brito, AF; Laranjo, M; Paixão, JA; Pinho E Melo, TM; Silva, MR; Soares, MI | 1 |
| Harries, M; Ward, SE | 1 |
| Dean, IN; Rawal, SY; Stein, SH; Tipton, DA | 1 |
| Harbord, N | 1 |
| Geoerger, B; Leblond, P | 1 |
| Allan, SA | 1 |
| Blay, JY; Chaigneau, L; Curtit, E; Dobi, E; Kalbacher, E; Mansi, L; Nguyen, T; Pivot, X; Viel, E | 1 |
| Beeharry, N; Connolly, DC; Godwin, AK; Golemis, EA; Li, T; Litwin, S; Pathak, HB; Ratushny, V; Tikhmyanova, N; Weiner, LM; Xiao, F; Yen, TJ | 1 |
| Ansorge, S; Bank, U; Biton, A; Brocke, S; Reinhold, D; Täger, M | 1 |
| Aita, Y; Hara, H; Ikeda, T; Ishii, KA; Isobe, K; Kawakami, Y; Saito, Y; Shimano, H; Takekoshi, K; Tanaka, Y | 1 |
| Akita, K; Fujii, I; Gouda, M; Ishihama, Y; Kirii, Y; Kitagawa, D; Narumi, Y; Sugiyama, N; Yokota, K | 1 |
| Baiuomy, AR; Elmegeed, GA; Eskander, EF; Mohareb, RM; William, MG | 1 |
| Corn, PG; Dayyani, F; Gallick, GE; Logothetis, CJ | 1 |
| Kim, EJ; Zalupski, MM | 1 |
| Ashraf, M; Kamal, A; Kashi Reddy, M; Khan, MN; Lavanya, A; Pal-Bhadra, M; Pushpavalli, SN; Ramaiah, MJ; Srikanth, YV | 1 |
| Pettipher, R; Whittaker, M | 1 |
| Knecht, R; Kurzweg, T; Laban, S; Möckelmann, N | 1 |
| Chen, KF; Chen, PJ; Cheng, AL; Lin, JP; Liu, CY; Shiau, CW; Tai, WT; Yu, HC | 1 |
| Kaplancıklı, ZA; Karaca, H; Özkay, Y; Tunalı, Y; Yurttaş, L | 1 |
| Gupta, A; Kalonia, H; Kumar, A; Mishra, J; Sharma, N | 1 |
| Airley, R | 1 |
| Argyle, DJ; Bavcar, S | 1 |
| Balakrishnar, B; Clements, A; Gao, B; Gurney, H; Wong, M; Yeap, S | 1 |
| Ali, MA; Ali, S; Almansour, AI; Choon, TS; Elumalai, KK; Ismail, R; Pandian, S; Sellappan, V | 1 |
| Chang, AY; Wang, M | 1 |
| Botelho, MF; Brito, AF; Laranjo, M; Paixão, JA; Pinho e Melo, TM; Soares, MI | 1 |
| Angelucci, A; Botta, M; Brullo, C; Christopher, RS; Crespan, E; Delle Monache, S; Kissova, M; Maga, G; Mori, M; Musumeci, F; Radi, M; Sanità, P; Schenone, S; Tintori, C | 1 |
| Andriamanana, I; Duretz, B; Gana, I; Hulin, A | 1 |
| Robert, C; Sibaud, V | 1 |
| Ali, MA; Choon, TS; Ranjith Kumar, R; Sivakumar, S | 1 |
| Hussar, DA | 1 |
| Kabadere, S; Kus, G; Oztopcu-Vatan, P; Uyar, R | 1 |
| Chen, LT; Chen, TS; Chiang, NJ; Hsueh, YS; Ko, CH; Li, CF; Lin, CL; Shan, YS; Shih, NY; Wang, LM; Yen, CC | 1 |
| Beijnen, JH; de Vries, N; Schinkel, AH; Sparidans, RW; Tang, SC; Wagenaar, E | 1 |
| Bartz-Schmidt, KU; Bayyoud, T; Hofmann, J; Spitzer, M; Yoeruek, E | 1 |
| Butte, AJ; De Vusser, K; Fischbein, MP; Gong, Y; Khatri, P; Kimura, N; Morgan, AA; Naesens, M; Robbins, RC; Roedder, S; Sarwal, MM | 1 |
| Bonkovsky, HL; Hwang, SI; Lee, JG; McKinney, KQ; Mougeot, JL | 1 |
| Fadda, AA; Refat, HM | 1 |
| Ikeda, K; Ikejiri, M; Ishiyama, T; Murai, T; Nakako, T; Taiji, M | 1 |
| Narayanapillai, S; Sham, YY; Xing, C; Zhang, W; Zhuang, C | 1 |
| Ambrosini, G; de Stanchina, E; Musi, E; Schwartz, GK | 1 |
| Grisanti, S; Lüke, J; Lüke, M; Nassar, K; Soliman, M; Tura, A | 1 |
| Abrantes, AM; Botelho, MF; Brito, AF; Gonçalves, C; Laranjo, M; Oliveira, AS; Pinho e Melo, TM; Santos, K; Sarmento Ribeiro, AB; Soares, MI | 1 |
| Beaune, P; de Waziers, I; Favre, A; Figg, WD; Kiehl, P; McMullen, J; Montemurro, M; Narjoz, C; Rochat, B | 1 |
| Baxter, RC; Gill, AJ; Hugh, TJ; Julovi, SM; Pavlakis, N; Peters, L; Samra, JS; Smith, RC; Wong, MH; Xue, A | 1 |
| Carlson, J; DeBold, JF; Hwa, LS; Miczek, KA; Quadros, IM; Shimamoto, A | 1 |
| Alm, R; Basarab, GS; Bist, S; Dangel, PB; Eakin, AE; Garner, CE; Green, O; Hauck, S; Hill, PJ; Hull, K; Illingworth, R; Manchester, JI; Rooney, M; Sherer, BA; Uria-Nickelsen, M; Zhou, F | 1 |
| Crews, LA; Gonzales, T; Kouznetsova, VL; Masliah, E; Overk, CR; Patrick, C; Paulino, A; Price, D; Rockenstein, E; Stocking, E; Tsigelny, IF; Wrasidlo, W | 1 |
| Acin, Y; Adenis, A; Bertucci, F; Blay, JY; Blésius, A; Bompas, E; Bouché, O; Bui-Nguyen, B; Bulusu, VR; Chaigneau, L; Domont, J; Dubreuil, P; Hermine, O; Isambert, N; Le Cesne, A; Mansfield, CD; Moussy, A; Ray-Coquard, I; Van Tine, BA | 1 |
| London, CA | 1 |
| Cheng, S; Coleman, M; Guo, A; Lu, P; Ma, J; Wang, YL | 1 |
| Alonso-Alvarez, C; Galván, I; Wakamatsu, K | 1 |
| Galanis, A; Levis, M | 1 |
| Attanzio, A; Barraja, P; Carbone, A; Cirrincione, G; Di Vita, G; Diana, P; Livrea, MA; Montalbano, A; Parrino, B; Spanò, V; Tesoriere, L | 1 |
| Attanzio, A; Barraja, P; Carbone, A; Ciancimino, C; Cirrincione, G; Di Vita, G; Diana, P; Livrea, MA; Montalbano, A; Parrino, B; Spanò, V; Tesoriere, L | 1 |
| Bdzhola, VG; Golub, AG; Gorbatiuk, OB; Lukashov, SS; Starosyla, SA; Volynets, GP; Yarmoluk, SM | 1 |
| Gui, Y; Li, L; Shi, Z; Singh, P; Walsh, MP; Yin, H; Yu, YN; Zheng, XL; Zhou, YX | 1 |
| Hao, WJ; Jiang, B; Li, G; Tu, SJ; Zhang, JP; Zhou, P | 1 |
| Altieri, A; Andreev, IA; Belov, DS; Curreli, F; Debnath, AK; Kurkin, AV; Kwon, YD; Kwong, PD; Scacalossi, D; Tikhonov, AA; Zhang, H | 1 |
| Anastasina, M; Bamford, DH; De Brabander, JK; Islam, MM; Julkunen, I; Kainov, D; Matikainen, S; Nyman, TA; Poranen, MM; Saelens, X; Šaulienė, I; Söderholm, S; Stenman, J; Tynell, J | 1 |
| Warren, RB; Yiu, ZZ | 1 |
| Murata, M; Noda, K; Terasawa, N | 1 |
| Gupte, A; Hawkins, CJ; Miles, MA; Shekhar, TM; Tascone, B; Taylor, S; Walkley, CR | 1 |
| Asok, A; Rosen, JB; Schulkin, J | 1 |
| Kłoczko, J; Ołdziej, AE; Romaniuk, W; Zińczuk, J | 1 |
| Bi, L; Gomez, M; Haug, J; Kimlinger, T; Kumar, S; Mukhopadhyay, B; Painuly, U; Prasad, V; Rajkumar, SV; Ramakrishnan, V | 1 |
| Altieri, A; Belov, DS; Curreli, F; Debnath, AK; Kurkin, AV; Patel, N; Ramesh, RR | 1 |
| Bamford, DH; Bugai, A; De Brabander, J; Fu, Y; Gaelings, L; Hukkanen, V; Julkunen, I; Kainov, DE; Kuisma, M; Le Goffic, R; Lorey, MB; Marjomäki, V; Matikainen, S; Miller, MS; Nandania, J; Nyman, TA; Paavilainen, H; Saelens, X; Schepens, B; Söderholm, S; Tynell, J; Vande Ginste, L; Velagapudi, V | 1 |
| Abdel Aziz, YM; Al-Dhfyan, A; Barakat, A; El Ashry, ESH; El Tamany, ESH; Lotfy, G; Said, MM | 1 |
| Altieri, A; Belov, DS; Curreli, F; Debnath, AK; Kurkin, AV; Kwon, YD; Kwong, PD; Ramesh, RR | 1 |
| Camargo, C; Giesler, LJ; Hunt, TE; Siegfried, BD | 1 |
| Eckmann, L; Fokin, VV; Kalisiak, J; Kim, WJ; Korthals, KA; Le, C; Li, S; Miyamoto, Y; Sharpless, KB | 1 |
| Ito, S; Sarna, T; Wakamatsu, K | 1 |
| Bartringer, J; Bulut, I; Chávez, P; Chochos, CL; Fall, S; Heiser, T; Ibraikulov, OA; Leclerc, N; Lévêque, P | 1 |
| Armstrong, AW; Singh, S | 1 |
| Camarasa, MJ; Carriles, AA; de Lucio, H; Gago, F; Gamo, A; Gutiérrez, KJ; Hermoso, JA; Jiménez-Ruiz, A; Revuelto, A; Ruiz-Santaquiteria, M; Sánchez-Murcia, PA; Velázquez, S | 1 |
| Burvenich, IJG; Harris, MA; Hawkins, CJ; Parker, BS; Rigopoulos, A; Scott, AM; Shekhar, TM; Spurling, A; Walkley, CR; Zanker, D | 1 |
| Burkart, MD; Corpuz, JC; Davis, TD; Jaremko, MJ | 1 |
| Gong, W; Han, P; Hu, B; Jiang, M; Li, B; Liang, G; Zhang, T; Zhang, W | 1 |
| Ahmed, S; Altieri, A; Belov, DS; Benedict Victor, SM; Curreli, F; Debnath, AK; Iusupov, IR; Kurkin, AV; Markov, PO | 1 |
| Almengló, C; Álvarez, E; González-Juanatey, JR; González-Peteiro, M; Mosquera-Garrote, N | 1 |
| Del Bino, S; Hirobe, T; Ito, S; Wakamatsu, K | 1 |
| Du, YY; Gu, KS; Jiao, Y; Lei, Y; Liu, WT; Wei, W; Zhan, MN; Zhang, CJ; Zhang, TT; Zhang, YY; Zhao, CC | 1 |
| Bosco, B; Calheiros, J; Carvalho, ATP; Chlapek, P; Domingues, L; Fabian, P; Gomes, C; Inga, A; Monteiro, FA; Nunes, C; Piazza, S; Pinho E Melo, TMVD; Raimundo, L; Rajado, AT; Ramos, H; Reis, F; Reis, S; Saraiva, L; Silva, J; Soares, MIL; Veselska, R; Vlcek, P | 1 |
| Cao, ZR; Chen, Y; Chen, ZQ; Ding, J; Meng, LH; Wang, Y; Wang, YX; Xu, L; Yang, CH; Zhang, X | 1 |
| Abbas, S; Ali, T; Assiri, M; El-Sharief, M; Gouda, M; Helal, M; Salem, M | 1 |
| Bonifaz, A; Burrows, J; Eadie, K; Fahal, A; Konings, M; Lim, W; Nyuykonge, B; Perry, B; Samby, K; Smeets, J; Todd, M; van de Sande, W; Verbon, A | 1 |
30 review(s) available for pyrroles and thiazoles
| Article | Year |
|---|---|
Mitigating heterocycle metabolism in drug discovery.
Topics: Animals; Biotransformation; Databases, Factual; Drug Discovery; Drug Interactions; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds, 4 or More Rings; Humans; Mice; Pharmaceutical Preparations; Rats | 2012 |
Experimental chemotherapy of Schistosomiasis mansoni.
Topics: Administration, Oral; Animals; Antimony; Chemosterilants; Child; Cricetinae; Cysteine; Drug Evaluation; Drug Evaluation, Preclinical; Ethylenediamines; Haplorhini; Humans; Injections, Intramuscular; Mice; Nitro Compounds; Nitrofurans; Oxadiazoles; Propylamines; Pyrimidines; Pyrroles; Quinolines; Ribonucleosides; Schistosoma mansoni; Schistosomiasis; Schistosomicides; Thiazoles; Thioxanthenes; Trypsin Inhibitors; Vinyl Compounds | 1974 |
Chemotherapy of Plasmodium berghei.
Topics: Animals; Anthracenes; Anti-Bacterial Agents; Anti-Infective Agents; Antimalarials; Benzene Derivatives; Cardiovascular System; Central Nervous System; Coloring Agents; Enzyme Inhibitors; Erythropoiesis; Histamine; Hormones; Malaria; Malaria, Avian; Mice; Naphthyridines; Organometallic Compounds; Plasmodium; Pteridines; Pyrimidines; Pyrroles; Quinolines; Rats; Sulfonamides; Sulfones; Thiazoles; Vitamins | 1969 |
Novel pyrrolo- and thiazolo-imidazoles.
Topics: Animals; Antiviral Agents; Chemical Phenomena; Chemistry, Physical; Humans; Imidazoles; Pyrroles; Receptors, GABA-A; Structure-Activity Relationship; Thiazoles | 1995 |
[Post myocardial infarction management].
Topics: Aftercare; Anticholesteremic Agents; Antioxidants; Atorvastatin; Chromans; Clopidogrel; Diet, Fat-Restricted; Heptanoic Acids; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Pyrroles; Risk Factors; Thiazoles; Thiazolidinediones; Ticlopidine; Troglitazone | 1997 |
Biotransformation reactions of five-membered aromatic heterocyclic rings.
Topics: Animals; Cytochrome P-450 Enzyme System; Furans; Heterocyclic Compounds, 4 or More Rings; Humans; Imidazoles; Indoles; Isoxazoles; Models, Chemical; Molecular Structure; Oxadiazoles; Oxazoles; Pyrazoles; Pyrroles; Tetrazoles; Thiadiazoles; Thiazoles; Thiophenes; Triazoles; Xenobiotics | 2002 |
Chemistry of 2-acetyl-1-pyrroline, 6-acetyl-1,2,3,4-tetrahydropyridine, 2-acetyl-2-thiazoline, and 5-acetyl-2,3-dihydro-4H-thiazine: extraordinary Maillard flavor compounds.
Topics: Flavoring Agents; Food Additives; Food Industry; Maillard Reaction; Pyridines; Pyrroles; Thiazines; Thiazoles | 2006 |
Beyond imatinib: second generation c-KIT inhibitors for the management of gastrointestinal stromal tumors.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Benzamides; Bevacizumab; Clinical Trials as Topic; Dasatinib; Drug Resistance, Neoplasm; Everolimus; Gastrointestinal Stromal Tumors; Humans; Imatinib Mesylate; Immunosuppressive Agents; Indoles; Niacinamide; Oligonucleotides; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Pyrimidines; Pyrroles; Sirolimus; Staurosporine; Sunitinib; Thiazoles | 2006 |
[Acute lymphoblastic leukemia with Philadelphia chromosome: treatment with kinase inhibitors].
Topics: Alkyl and Aryl Transferases; Antineoplastic Agents; Benzamides; Benzenesulfonates; Dasatinib; Drug Resistance, Neoplasm; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Indoles; Niacinamide; Phenylurea Compounds; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Pyridines; Pyrimidines; Pyrroles; Sorafenib; Sunitinib; Thiazoles | 2007 |
New developments in multitargeted therapy for patients with solid tumours.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Benzenesulfonates; Clinical Trials as Topic; Dasatinib; Drug Delivery Systems; Humans; Imatinib Mesylate; Indoles; Neoplasms; Niacinamide; Phenylurea Compounds; Piperazines; Pyridines; Pyrimidines; Pyrroles; Sorafenib; Sunitinib; Thiazoles | 2008 |
[Gastrointestinal stromal tumors: molecular aspects and therapeutic implications].
Topics: Antineoplastic Agents; Benzamides; Benzenesulfonates; Disease Progression; Drug Resistance, Neoplasm; Gastrointestinal Stromal Tumors; Humans; Imatinib Mesylate; Indoles; Mutation; Neoplasm Proteins; Niacinamide; Oligonucleotides; Phenylurea Compounds; Phthalazines; Piperazines; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Pyridines; Pyrimidines; Pyrroles; Receptor, Platelet-Derived Growth Factor alpha; Sorafenib; Staurosporine; Sunitinib; Thiazoles | 2008 |
Clinical pharmacokinetics of tyrosine kinase inhibitors.
Topics: Administration, Oral; Antineoplastic Agents; Benzamides; Benzenesulfonates; Biological Availability; Cytochrome P-450 Enzyme System; Dasatinib; Drug Interactions; Erlotinib Hydrochloride; Gefitinib; Humans; Imatinib Mesylate; Indoles; Intestinal Absorption; Lapatinib; Niacinamide; Phenylurea Compounds; Piperazines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyridines; Pyrimidines; Pyrroles; Quinazolines; Sorafenib; Sunitinib; Thiazoles; Tissue Distribution | 2009 |
[Focus on GIST management].
Topics: Antineoplastic Agents; Benzamides; Benzenesulfonates; Chemotherapy, Adjuvant; Drug Resistance, Neoplasm; Gastrointestinal Stromal Tumors; Humans; Imatinib Mesylate; Indoles; Niacinamide; Phenylurea Compounds; Piperazines; Piperidines; Protein Kinase Inhibitors; Pyridines; Pyrimidines; Pyrroles; Sorafenib; Sunitinib; Thiazoles | 2010 |
Targeting apoptosis pathways by natural compounds in cancer: marine compounds as lead structures and chemical tools for cancer therapy.
Topics: Alkaloids; Alkanes; Animals; Anti-Bacterial Agents; Antineoplastic Agents; Apoptosis; Aquatic Organisms; Biological Products; Bryostatins; Carbamates; Cell Proliferation; Depsipeptides; Dioxoles; Drug Screening Assays, Antitumor; Humans; Lactones; Macrolides; Microtubules; Models, Chemical; Neoplasms; Phenanthrolines; Phenazines; Proteasome Endopeptidase Complex; Pyrones; Pyrroles; Quinolines; Spiro Compounds; Steroids; Tetrahydroisoquinolines; Thiazoles; Trabectedin | 2013 |
Recent advances in the discovery of selective AMPA receptor positive allosteric modulators.
Topics: Allosteric Regulation; Benzamides; Drug Evaluation, Preclinical; Pyrazoles; Pyrroles; Receptors, AMPA; Sulfonamides; Thiazoles; Thiophenes | 2010 |
Novel nephrotoxins.
Topics: Adenine; Alcohols; Angiogenesis Inhibitors; Anticonvulsants; Antipsychotic Agents; Dasatinib; Diphosphonates; Glutamates; Guanine; HIV Protease Inhibitors; Humans; Indoles; Kidney Diseases; Organophosphonates; Oxalates; Pamidronate; Pemetrexed; Phenindione; Plants, Toxic; Proton Pump Inhibitors; Pyrimidines; Pyrroles; Selective Serotonin Reuptake Inhibitors; Sunitinib; Tenofovir; Thiazoles; Triazines | 2011 |
[Indications and current development of new targeted therapies in pediatric oncology].
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Benzamides; Benzenesulfonates; Bevacizumab; Child; Dasatinib; Erlotinib Hydrochloride; Hedgehog Proteins; Humans; Imatinib Mesylate; Indoles; Integrins; Molecular Targeted Therapy; Neoplasms; Niacinamide; Nifurtimox; Phenylurea Compounds; Piperazines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyridines; Pyrimidines; Pyrroles; Quinazolines; Sorafenib; Sunitinib; Thiazoles; TOR Serine-Threonine Kinases | 2011 |
Novel therapies for metastatic castrate-resistant prostate cancer.
Topics: Androstenes; Androstenols; Angiogenesis Inhibitors; Anilides; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Atrasentan; Benzamides; Bevacizumab; Biomarkers, Tumor; Bone Remodeling; Cancer Vaccines; Clinical Trials as Topic; Clusterin; Dasatinib; Denosumab; Endothelin-1; Humans; Immunotherapy; Indoles; Ipilimumab; Male; Mice; Mice, SCID; Molecular Targeted Therapy; Nitriles; Orchiectomy; Phenylthiohydantoin; Prostate-Specific Antigen; Prostatic Neoplasms; Pyridines; Pyrimidines; Pyrroles; Pyrrolidines; RANK Ligand; Receptor Cross-Talk; Receptors, Androgen; Signal Transduction; Sunitinib; Taxoids; Thiazoles; Tissue Extracts; Treatment Failure; Tumor Microenvironment; Xenograft Model Antitumor Assays | 2011 |
Systemic therapy for advanced gastrointestinal stromal tumors: beyond imatinib.
Topics: Antineoplastic Agents; Benzamides; Gastrointestinal Neoplasms; Gastrointestinal Stromal Tumors; Humans; Imatinib Mesylate; Indoles; Mutation; Piperazines; Piperidines; Proto-Oncogene Proteins c-kit; Pyridines; Pyrimidines; Pyrroles; Receptors, Platelet-Derived Growth Factor; Sunitinib; Thiazoles | 2011 |
Update on the development of antagonists of chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2). From lead optimization to clinical proof-of-concept in asthma and allergic rhinitis.
Topics: Acetates; Animals; Asthma; Aza Compounds; Carbazoles; Clinical Trials as Topic; Humans; Indoleacetic Acids; Pyrazoles; Pyrimidines; Pyrroles; Receptors, Immunologic; Receptors, Prostaglandin; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Sulfonamides; Th2 Cells; Thiazoles | 2012 |
Current treatment options for recurrent/metastatic head and neck cancer: a post-ASCO 2011 update and review of last year's literature.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Benzodioxoles; Carcinoma, Squamous Cell; Cetuximab; Combined Modality Therapy; Dasatinib; ErbB Receptors; Fluorouracil; Gefitinib; Head and Neck Neoplasms; Humans; Indoles; Neoplasm Recurrence, Local; Palliative Care; Pyrimidines; Pyrroles; Quinazolines; Quinazolinones; Salvage Therapy; Squamous Cell Carcinoma of Head and Neck; Sunitinib; Thiazoles | 2012 |
Receptor tyrosine kinase inhibitors: molecularly targeted drugs for veterinary cancer therapy.
Topics: Animals; Antineoplastic Agents; Benzamides; Drug Therapy, Combination; Humans; Indoles; Neoplasms; Piperidines; Pyridines; Pyrroles; Receptor Protein-Tyrosine Kinases; Thiazoles | 2012 |
Evidence for therapeutic drug monitoring of targeted anticancer therapies.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents; Area Under Curve; Benzamides; Benzenesulfonates; Cetuximab; Dasatinib; Drug Monitoring; Everolimus; Evidence-Based Medicine; Half-Life; Humans; Imatinib Mesylate; Indoles; Injections, Intravenous; Molecular Targeted Therapy; Neoplasms; Niacinamide; Phenylurea Compounds; Piperazines; Pyridines; Pyrimidines; Pyrroles; Rituximab; Sirolimus; Sorafenib; Sunitinib; Thiazoles | 2012 |
[Pigmentary disorders induced by anticancer agents. Part II: targeted therapies].
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Benzamides; Cetuximab; Dasatinib; ErbB Receptors; Humans; Imatinib Mesylate; Indazoles; Indoles; Ipilimumab; Niacinamide; Phenylurea Compounds; Pigmentation Disorders; Piperazines; Piperidines; Programmed Cell Death 1 Receptor; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Quinazolines; Receptors, Vascular Endothelial Growth Factor; Sorafenib; Sulfonamides; Sunitinib; Thiazoles | 2013 |
Small molecule inhibitors in veterinary oncology practice.
Topics: Animals; Benzamides; Cat Diseases; Cats; Dog Diseases; Dogs; Indoles; Neoplasms; Piperidines; Protein Kinase Inhibitors; Pyridines; Pyrroles; Thiazoles | 2014 |
Novel Oral Therapies for Psoriasis and Psoriatic Arthritis.
Topics: Adamantane; Adenosine; Adenosine A3 Receptor Antagonists; Administration, Oral; Arthritis, Psoriatic; Azetidines; Biological Factors; Biological Therapy; Clinical Trials as Topic; Humans; Isonicotinic Acids; Janus Kinases; Niacinamide; Phosphodiesterase 4 Inhibitors; Piperidines; Protein Kinase Inhibitors; Psoriasis; Purines; Pyrazoles; Pyrimidines; Pyrroles; Receptors, Lysosphingolipid; rho-Associated Kinases; Sulfonamides; Thalidomide; Thiazoles | 2016 |
[Proteasome inhibitors in cancer therapy].
Topics: Antineoplastic Agents; Apoptosis; Boronic Acids; Bortezomib; Caspases; Dipeptides; Humans; Lactones; Multiple Myeloma; Neoplasms; Oligopeptides; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Proteolysis; Pyrroles; Thiazoles; Threonine | 2015 |
Photodegradation of Eumelanin and Pheomelanin and Its Pathophysiological Implications.
Topics: Carboxylic Acids; Eye; Humans; Hydrogen Peroxide; Light; Melanins; Melanosomes; Pyrroles; Reactive Oxygen Species; Retinal Pigment Epithelium; Skin; Skin Aging; Thiazoles; Tyrosine; Ultraviolet Rays | 2018 |
Oral small molecules for psoriasis.
Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Humans; Patient Selection; Piperidines; Protein Kinase Inhibitors; Psoriasis; Pyrimidines; Pyrroles; Thalidomide; Thiazoles | 2018 |
Type II non-ribosomal peptide synthetase proteins: structure, mechanism, and protein-protein interactions.
Topics: Amino Acids; Benzoic Acid; Cyclopropanes; Hydroxylation; Lactams; Macrolides; Netropsin; Peptide Synthases; Proline; Protein Interaction Maps; Pyrroles; Thiazoles; Thiones | 2020 |
2 trial(s) available for pyrroles and thiazoles
| Article | Year |
|---|---|
Effects of rosiglitazone alone and in combination with atorvastatin on the metabolic abnormalities in type 2 diabetes mellitus.
Topics: Adult; Aged; Aged, 80 and over; Apolipoprotein A-I; Apolipoproteins B; Atorvastatin; Blood Glucose; Cholesterol, HDL; Cholesterol, LDL; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Double-Blind Method; Drug Evaluation; Drug Therapy, Combination; Female; Glycated Hemoglobin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Hypolipidemic Agents; Male; Middle Aged; North America; Pyrroles; Rosiglitazone; Safety; Thiazoles; Thiazolidinediones; Time Factors; Treatment Outcome | 2002 |
Masitinib in advanced gastrointestinal stromal tumor (GIST) after failure of imatinib: a randomized controlled open-label trial.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Benzamides; Disease-Free Survival; Female; Gastrointestinal Stromal Tumors; Humans; Imatinib Mesylate; Indoles; Male; Middle Aged; Piperazines; Piperidines; Prospective Studies; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Pyridines; Pyrimidines; Pyrroles; Sunitinib; Thiazoles; Treatment Failure | 2014 |
154 other study(ies) available for pyrroles and thiazoles
| Article | Year |
|---|---|
Highly selective inhibitors of thromboxane synthetase. 2. Pyridine derivatives.
Topics: Animals; Oxidoreductases; Pyridines; Sheep; Structure-Activity Relationship; Thromboxane-A Synthase | 1981 |
Cytotoxic and radiosensitizing effects of hypoxic cell sensitizers on EMT6 mouse mammary tumour cells in vivo and in vitro.
Topics: Animals; Cell Survival; In Vitro Techniques; Lethal Dose 50; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Nitroimidazoles; Oxygen; Pyrroles; Radiation-Sensitizing Agents; Thiazoles | 1978 |
Mutagenicity of nitrofurans, nitrothiophenes, nitropyrroles, nitroimidazole, aminothiophenes, and aminothiazoles in Salmonella typhimurium.
Topics: Amines; DNA Repair; DNA, Bacterial; Heterocyclic Compounds; Mutagens; Nitro Compounds; Nitrofurans; Nitroimidazoles; Pyrroles; Salmonella typhimurium; Structure-Activity Relationship; Thiazoles; Thiophenes | 1975 |
FTIR study of specific binding interactions between DNA minor groove binding ligands and polynucleotides.
Topics: Bisbenzimidazole; DNA; Fourier Analysis; Netropsin; Nucleic Acid Conformation; Polynucleotides; Pyrroles; Spectrophotometry, Infrared; Thiazoles | 1992 |
Veratridine activates a silent sodium channel in rat isolated aorta.
Topics: Amiloride; Animals; Aorta; Benzothiazoles; Calcium; Guanidine; Guanidines; In Vitro Techniques; Piperidines; Pyrroles; Rats; Sodium Channels; Tetrodotoxin; Thiazoles; Vasodilator Agents; Veratridine | 1992 |
The protein kinase C inhibitor, calphostin C, inhibits succinate-dependent mitochondrial reduction of MTT by a mechanism that does not involve protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bone Marrow; Carbazoles; Cell Division; Cell Line; Coloring Agents; DNA Replication; Indoles; Isoquinolines; Kinetics; Mice; Mice, Inbred C3H; Mitochondria; Naphthalenes; Oxidation-Reduction; Piperazines; Polycyclic Compounds; Protein Kinase C; Protein Kinase Inhibitors; Pyrroles; Succinates; Tetrazolium Salts; Thiazoles; Thymidine | 1992 |
[Determination of the main metabolite (desethyl KBT-3022) of a new antiplatelet agent, KBT-3022 in plasma by gas chromatography].
Topics: Administration, Oral; Animals; Chromatography, Gas; Dogs; Platelet Aggregation Inhibitors; Pyrroles; Thiazoles | 1992 |
Photo-stability of the new antiplatelet agent, KBT-3022 (ethyl 2-[4,5-bis(4-methoxyphenyl)thiazole-2-yl]pyrrol-1-ylacetate) in aqueous solutions containing acetonitrile.
Topics: Acetonitriles; Drug Stability; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Light; Platelet Aggregation Inhibitors; Pyrroles; Spectrophotometry, Ultraviolet; Temperature; Thiazoles | 1992 |
Veratridine-induced intoxication in the isolated left atrium of the rat: effects of some anti-ischemic compounds.
Topics: Animals; Atrial Function, Left; Benzothiazoles; Calcium; Coronary Disease; Dose-Response Relationship, Drug; Heart; In Vitro Techniques; Male; Piperidines; Pyrroles; Rats; Sodium; Sodium Channels; Thiazoles; Veratridine | 1991 |
Determination of the antiplatelet agent. KB-3022, and its metabolite by high-performance liquid chromatography.
Topics: Animals; Chromatography, High Pressure Liquid; Humans; Male; Platelet Aggregation Inhibitors; Pyrroles; Rats; Rats, Inbred Strains; Thiazoles | 1990 |
Synthesis and oral antiallergic activity of carboxylic acids derived from imidazo[2,1-c][1,4]benzoxazines, imidazo[1,2-a]quinolines, imidazo[1,2-a]quinoxalines, imidazo[1,2-a]quinoxalinones, pyrrolo[1,2-a]quinoxalinones, pyrrolo[2,3-a]quinoxalinones, and
Topics: Animals; Carboxylic Acids; Cromolyn Sodium; Histamine H1 Antagonists; Hypersensitivity; Imidazoles; Oxazines; Passive Cutaneous Anaphylaxis; Pyrroles; Quinoxalines; Rats; Structure-Activity Relationship; Thiazoles | 1988 |
Synthesis and antineoplastic activity of 5-aryl-2,3-dihydropyrrolo[2,1-b]thiazole-6,7-dimethanol 6,7-bis(isopropylcarbamates).
Topics: Carbamates; Cell Division; Cell Survival; Chemical Phenomena; Chemistry; Colonic Neoplasms; Humans; Leukemia, Myeloid; Neoplasms; Pyrroles; Structure-Activity Relationship; Thiazoles; Tumor Cells, Cultured | 1988 |
[Perhydropyrrolo [2,1-b] thiazolones: synthesis and study of their chemical and pharmacologic properties].
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical Phenomena; Chemistry; Pyrroles; Thiazoles | 1987 |
Radiation chemistry of nitrogen and sulfur heterocyclics.
Topics: Chromatography, Gas; Free Radicals; Heterocyclic Compounds; Imidazoles; Nitrogen; Pyrazines; Pyrazoles; Pyrimidines; Pyrroles; Radiochemistry; Sulfur; Tetrazoles; Thiazoles; Thiophenes; Triazines; Triazoles | 1973 |
Thiamine-induced formation of the monopyrrole moiety of prodigiosin.
Topics: Anti-Bacterial Agents; Culture Media; Glycerol; Mutation; Pigments, Biological; Prodigiosin; Pyrimidines; Pyrroles; Serratia marcescens; Thiamine; Thiazoles | 1968 |
A comparison of the specificities of xanthine oxidase and aldehyde oxidase.
Topics: Alcohols; Aldehydes; Amines; Animals; Cattle; Chlorine; Ferricyanides; Imidazoles; Ketones; Kinetics; Liver; Methylamines; Milk; Nitriles; Oxidoreductases; Pteridines; Purines; Pyrazoles; Pyridines; Pyrimidines; Pyrroles; Rabbits; Spectrophotometry; Structure-Activity Relationship; Sulfhydryl Compounds; Sulfides; Sulfones; Thiazoles; Xanthine Oxidase | 1972 |
[Critical study of new contraceptive methods].
Topics: Acetates; Adult; Antibodies; Antineoplastic Agents; Busulfan; Contraceptives, Oral; Depression, Chemical; Estrogens; Female; Fertilization; Humans; Intrauterine Devices; Male; Medroxyprogesterone; Mestranol; Methods; Nitrofurans; Norethindrone; Norethynodrel; Pyrroles; Spermatozoa; Thiazoles; Triethylenemelamine | 1971 |
Pteridines. 8. Some 2,4,7-triamino-6-heteroarylpteridines.
Topics: Chromatography, Paper; Furans; Hydrogen-Ion Concentration; Imidazoles; Oxazoles; Pteridines; Pyrazoles; Pyridines; Pyrimidines; Pyrroles; Spectrum Analysis; Thiazoles; Thiophenes; Triazoles; Ultraviolet Rays | 1968 |
Studies of heterocyclic compounds. IV. Electropholic substitution of 6-methylpyrrolo[2,1-b]thiazole.
Topics: Chemical Phenomena; Chemistry; Pyrroles; Thiazoles | 1966 |
Inhibitory effect of KBT-3022, a new anti-platelet agent, on infiltration of polymorphonuclear leukocytes induced by leukotriene B4 or formyl-methionyl-leucyl-phenylalanine in mice.
Topics: Animals; Dexamethasone; Dose-Response Relationship, Drug; Indomethacin; Leukocytes; Leukotriene B4; Mice; Mice, Inbred Strains; N-Formylmethionine Leucyl-Phenylalanine; Platelet Aggregation Inhibitors; Pyrroles; Thiazoles | 1995 |
Genotoxicity of 1,3-dithiane and 1,4-dithiane in the CHO/SCE assay and the Salmonella/microsomal test.
Topics: Animals; Biotransformation; CHO Cells; Cricetinae; Furans; Heterocyclic Compounds; Imidazoles; Maillard Reaction; Mutagenicity Tests; Mutagens; Pyrazines; Pyridines; Pyrroles; Salmonella typhimurium; Sister Chromatid Exchange; Sulfur Compounds; Thiazoles; Thiophenes | 1994 |
Anti-thrombotic activity of KBT-3022 in experimental models of thrombosis.
Topics: Animals; Arachidonic Acid; Aspirin; Cyclooxygenase Inhibitors; Extracorporeal Circulation; Guinea Pigs; In Vitro Techniques; Indomethacin; Male; Mice; Mice, Inbred Strains; Platelet Aggregation Inhibitors; Pyrroles; Rabbits; Silver Nitrate; Thiazoles; Thrombosis; Ticlopidine | 1995 |
Study of the Mannich reaction: beta-amino-methylation of N-aryl and N-azaheteroaryl-substituted 2,5-dimethylpyrroles, compounds with potential biological activity.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Bacteria; Candida; Chemical Phenomena; Chemistry, Physical; Fungi; Mannich Bases; Pyridines; Pyrimidines; Pyrroles; Thiazoles | 1995 |
The effects of KBT-3022, a new anti-platelet agent, on hemorheological properties in guinea pigs.
Topics: 2,3-Diphosphoglycerate; Adenosine Triphosphate; Animals; Aspirin; Blood Viscosity; Diphosphoglyceric Acids; Drug Evaluation, Preclinical; Erythrocyte Deformability; Fibrinogen; Guinea Pigs; Hematocrit; Hemorheology; Pentoxifylline; Plasma; Platelet Aggregation Inhibitors; Pyrroles; Thiazoles; Ticlopidine | 1995 |
Melanins in IGR 1 melanoma cells.
Topics: Chromatography, Liquid; Cysteinyldopa; Dicarboxylic Acids; Humans; Hydrolysis; Mass Spectrometry; Melanins; Melanoma; Monophenol Monooxygenase; Neoplasm Proteins; Oxidation-Reduction; Potassium Permanganate; Pyrroles; Sulfur; Thiazoles; Tumor Cells, Cultured; Tyrosine | 1994 |
Relationship between glutathione concentration and metabolism of the pyrrolizidine alkaloid, monocrotaline, in the isolated, perfused liver.
Topics: Analysis of Variance; Animals; Antimetabolites, Antineoplastic; Bile; Buthionine Sulfoximine; Ethylene Chlorohydrin; Glutathione; Liver; Male; Maleates; Methionine Sulfoximine; Monocrotaline; Perfusion; Pyrroles; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidines | 1995 |
Synthesis and structure-activity relationships of peptidyl alpha-keto heterocycles as novel inhibitors of prolyl endopeptidase.
Topics: Animals; Hydrogen Bonding; Kidney; Magnetic Resonance Spectroscopy; Molecular Structure; Nitrogen; Prolyl Oligopeptidases; Pyrroles; Serine Endopeptidases; Serine Proteinase Inhibitors; Structure-Activity Relationship; Swine; Thiazoles | 1994 |
Melanins and lens pigments: a comparative study.
Topics: Cataract; Chromatography, High Pressure Liquid; Dicarboxylic Acids; Lens, Crystalline; Melanins; Pigments, Biological; Pyrroles; Thiazoles | 1993 |
Thiazohalostatin, a new cytoprotective substance produced by Actinomadura. I. Taxonomy, production, isolation and biological activities.
Topics: Actinomycetaceae; Animals; Cell Death; Down-Regulation; Fermentation; Lipid Peroxidation; Mice; Pyrroles; Rats; Thiazoles | 1993 |
Thiazohalostatin, a new cytoprotective substance produced by Actinomadura. II. Physico-chemical properties and structure determination.
Topics: Actinomycetaceae; Magnetic Resonance Spectroscopy; Mass Spectrometry; Pyrroles; Spectrophotometry; Thiazoles | 1993 |
Effect of KBT-3022, a new diphenylthiazole derivative, on platelet functions.
Topics: Adenosine Diphosphate; Administration, Oral; Animals; Arachidonic Acid; Aspirin; Blood Platelets; Collagen; Edema; Erythema; Gastric Mucosa; Guinea Pigs; Humans; Mice; Platelet Aggregation Inhibitors; Pyrroles; Rabbits; Rats; Serotonin; Species Specificity; Thiazoles; Thrombin; Ultraviolet Rays | 1995 |
Effect of KBT-3022, a new cyclooxygenase inhibitor, on experimental brain edema in vitro and in vivo.
Topics: Animals; Arachidonic Acid; Aspirin; Brain; Brain Edema; Brain Ischemia; Cyclooxygenase Inhibitors; Gerbillinae; Guinea Pigs; In Vitro Techniques; Indomethacin; Lipid Peroxidation; Male; Pyrroles; Thiazoles | 1996 |
Protective effect of KBT-3022, a new cyclooxygenase inhibitor, in cerebral hypoxia and ischemia.
Topics: Adenosine Triphosphate; Animals; Brain Ischemia; Cell Survival; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hippocampus; Hypoxia; Male; Mice; Pyrroles; Thiazoles | 1995 |
Inhibitory effects of the new anti-platelet agent KBT-3022 and its metabolite on rabbit neutrophil function in vitro.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Binding Sites; Calcium; Cell Adhesion; Cilostazol; Complement C3-C5 Convertases; Complement C5a; Cyclooxygenase Inhibitors; Indomethacin; Leukotriene B4; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Platelet Aggregation Inhibitors; Pyrroles; Rabbits; Structure-Activity Relationship; Superoxides; Tetradecanoylphorbol Acetate; Tetrazoles; Thiazoles; Ticlopidine | 1996 |
The mechanism of action of KBT-3022, a new antiplatelet agent.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Arachidonic Acid; Blood Platelets; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme System; Epoprostenol; Guinea Pigs; In Vitro Techniques; Intramolecular Oxidoreductases; Isomerases; Male; Phosphatidic Acids; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Prostaglandin-Endoperoxide Synthases; Pyrroles; Rabbits; Thiazoles; Thrombin; Thromboxane A2; Thromboxane-A Synthase | 1997 |
Antithrombotic effects in a rat model of aspirin-insensitive arterial thrombosis of desethyl KBT-3022, the main active metabolite of a new antiplatelet agent, KBT-3022.
Topics: Animals; Aspirin; Femoral Artery; Light; Male; Phenylacetates; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyrroles; Rats; Rats, Wistar; Regional Blood Flow; Sulfonamides; Thiazoles; Thrombosis | 1997 |
Substituted tetrahydropyrrolo[2,1-b]oxazol-5(6H)-ones and tetrahydropyrrolo[2,1-b]thiazol-5(6H)-ones as hypoglycemic agents.
Topics: Animals; Cell Line; Diabetes Mellitus, Type 2; Drug Evaluation, Preclinical; Glucose; Hypoglycemic Agents; Male; Mice; Mice, Inbred C57BL; Muscles; Oxazoles; Pyrroles; Rats; Structure-Activity Relationship; Thiazoles | 1998 |
Pharmacological approaches to counter the toxicity of Dopa.
Topics: Animals; Benzothiazoles; Cells, Cultured; Cerebellum; Cytoplasmic Granules; Glutathione; Levodopa; Neuroprotective Agents; Pramipexole; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Selegiline; Thiazoles; Vitamin E | 1998 |
Environmental factors modulating antibiotic and siderophore biosynthesis by Pseudomonas fluorescens biocontrol strains.
Topics: Anti-Bacterial Agents; Colony Count, Microbial; Culture Media; Pest Control, Biological; Phenols; Phloroglucinol; Pseudomonas fluorescens; Pyrroles; Pyrrolnitrin; Salicylic Acid; Siderophores; Soil Microbiology; Thiazoles | 1999 |
Effects of selective dopamine D4 receptor blockers, NRA0160 and L-745,870, on A9 and A10 dopamine neurons in rats.
Topics: Animals; Antipsychotic Agents; Dopamine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Male; Neurons; Piperidines; Pyridines; Pyrroles; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, Dopamine D4; Substantia Nigra; Thiazoles; Ventral Tegmental Area | 1999 |
How to manage metabolic complications of HIV therapy: what to do while we wait for answers.
Topics: Anabolic Agents; Anti-HIV Agents; Anticholesteremic Agents; Atorvastatin; Exercise Therapy; Gemfibrozil; Growth Hormone; Guidelines as Topic; Heptanoic Acids; HIV Infections; Humans; Hypoglycemic Agents; Hypolipidemic Agents; Lipodystrophy; Metabolic Diseases; Metformin; Nucleosides; Protease Inhibitors; Pyrroles; Reverse Transcriptase Inhibitors; Risk Factors; Thiazoles; Thiazolidinediones | 2000 |
Design and synthesis of novel thiazole-containing cross-linked polyamides related to the antiviral antibiotic distamycin.
Topics: Antiviral Agents; Distamycins; DNA; DNA Topoisomerases, Type II; Magnetic Resonance Spectroscopy; Mass Spectrometry; Nylons; Oligopeptides; Pyrroles; Thiazoles; Topoisomerase II Inhibitors | 2000 |
Total synthesis of cyclosporin O both in solution and in the solid phase using novel thiazolium-, immonium-, and pyridinium-type coupling reagents: BEMT, BDMP, and BEP.
Topics: Chromatography, High Pressure Liquid; Cyclization; Cyclosporins; Immunosuppressive Agents; Indicators and Reagents; Pyridines; Pyrroles; Thiazoles | 2000 |
Potential interaction between troglitazone and atorvastatin.
Topics: Aged; Anticholesteremic Agents; Atorvastatin; Cholesterol, LDL; Chromans; Diabetes Mellitus; Drug Interactions; Drug Therapy, Combination; Female; Heptanoic Acids; Humans; Hyperlipidemias; Hypoglycemic Agents; Male; Middle Aged; Pyrroles; Retrospective Studies; Thiazoles; Thiazolidinediones; Triglycerides; Troglitazone | 2000 |
Thioxo amino acid pyrrolidides and thiazolidides: new inhibitors of proline specific peptidases.
Topics: Amino Acids; Animals; Dipeptidyl Peptidase 4; Hydrogen-Ion Concentration; Kinetics; Magnetic Resonance Spectroscopy; Proline; Protease Inhibitors; Pyrroles; Substrate Specificity; Swine; Thiazoles | 2000 |
Down-regulation of uncoupling protein-3 and -2 by thiazolidinediones in C2C12 myotubes.
Topics: Acyl-CoA Dehydrogenase; Animals; Atorvastatin; Bezafibrate; Carnitine O-Palmitoyltransferase; Carrier Proteins; Cell Line; Cholesterol; Chromans; Down-Regulation; Fatty Acid Desaturases; Heptanoic Acids; Hypoglycemic Agents; Ion Channels; Ligands; Membrane Transport Proteins; Mice; Mitochondrial Proteins; Muscles; Oleic Acid; Peroxisome Proliferators; Proteins; Pyrimidines; Pyrroles; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Triazenes; Troglitazone; Uncoupling Protein 2; Uncoupling Protein 3 | 2000 |
Pharmacological profile of YM-31636, a novel 5-HT3 receptor agonist, in vitro.
Topics: Acetylcholine; Action Potentials; Animals; Anthraquinones; Atrial Function; Biguanides; Binding, Competitive; Colon; Dinoprostone; Dose-Response Relationship, Drug; Guinea Pigs; Heart Atria; Humans; In Vitro Techniques; Muscle Contraction; Myocardial Contraction; Pyrroles; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Serotonin; Serotonin Receptor Agonists; Thiazoles | 2000 |
Oxidation of L-thiazolidine-4-carboxylate by delta1-pyrroline-5-carboxylate reductase in Escherichia coli.
Topics: Animals; Antioxidants; delta-1-Pyrroline-5-Carboxylate Reductase; Escherichia coli; Mice; Mutation; Oxidation-Reduction; Pyrroles; Pyrroline Carboxylate Reductases; Substrate Specificity; Thiazoles; Thiazolidines | 2001 |
Investigation of the effects of YM-31636, a novel 5-HT3 receptor agonist, on defecation in normal and constipated ferrets.
Topics: Animals; Citrates; Constipation; Defecation; Dose-Response Relationship, Drug; Feces; Ferrets; Male; Nausea; Organometallic Compounds; Picolines; Pyrroles; Serotonin Receptor Agonists; Thiazoles; Time Factors; Vomiting; Water | 2001 |
A novel 5-HT3 receptor agonist, YM-31636, increases gastrointestinal motility without increasing abdominal pain.
Topics: Abdominal Pain; Animals; Benzimidazoles; Colon; Defecation; Gastrointestinal Motility; Intestinal Mucosa; Male; Pressure; Pyrroles; Rats; Rats, Wistar; Reflex, Abdominal; Serotonin Antagonists; Serotonin Receptor Agonists; Thiazoles; Water | 2001 |
Risk of adverse events with concomitant use of atorvastatin or simvastatin and glucose-lowering drugs (thiazolidinediones, metformin, sulfonylurea, insulin, and acarbose).
Topics: Acarbose; Adverse Drug Reaction Reporting Systems; Anticholesteremic Agents; Atorvastatin; Chromans; Drug Interactions; Drug Therapy, Combination; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Insulin; Male; Metformin; Middle Aged; Pyrroles; Simvastatin; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Troglitazone | 2002 |
The effect of the selective 5-HT(3) receptor agonist on ferret gut motility.
Topics: Animals; Benzimidazoles; Colon; Defecation; Ferrets; Gastrointestinal Motility; Male; Muscle Contraction; Pyrroles; Serotonin Antagonists; Serotonin Receptor Agonists; Thiazoles | 2002 |
Antioxidative activity of heterocyclic compounds found in coffee volatiles produced by Maillard reaction.
Topics: Aldehydes; Antioxidants; Coffee; Furans; Heterocyclic Compounds; Maillard Reaction; Pyrazines; Pyrroles; Thiazoles; Thiophenes; Volatilization | 2002 |
Identification of potent odorants in different green tea varieties using flavor dilution technique.
Topics: Chromatography, Gas; Gas Chromatography-Mass Spectrometry; Humans; Indicator Dilution Techniques; Odorants; Pyrroles; Smell; Tea; Thiazoles; Volatilization | 2002 |
Pyrrolylbenzothiazole derivatives as aldose reductase inhibitors.
Topics: Aldehyde Reductase; Benzothiazoles; Enzyme Inhibitors; Kinetics; Molecular Structure; Pyrroles; Thiazoles | 2002 |
Peroxisome proliferator-activated receptor gamma thiazolidinedione agonists increase glucose metabolism in astrocytes.
Topics: Animals; Animals, Newborn; Astrocytes; Carbazoles; Cells, Cultured; Cerebral Cortex; Enzyme Inhibitors; Glucose; Glucose Transporter Type 1; Glycolysis; Hypoglycemic Agents; In Vitro Techniques; Indoles; Kinetics; Lactates; Monosaccharide Transport Proteins; Pioglitazone; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors | 2003 |
Effects of protein kinase C inhibition and activation on proliferation and apoptosis of bovine retinal pericytes.
Topics: Animals; Apoptosis; Cattle; Cell Count; Cell Division; DNA; Dose-Response Relationship, Drug; Enzyme Activators; Enzyme Inhibitors; Flow Cytometry; Glucose; Isoenzymes; Mesylates; Pericytes; Protein Kinase C; Pyrroles; Retina; Tetradecanoylphorbol Acetate; Tetrazolium Salts; Thiazoles | 2003 |
3,5,6-Trisubstituted naphthostyrils as CDK2 inhibitors.
Topics: Antimetabolites; Bromodeoxyuridine; CDC2-CDC28 Kinases; Cell Cycle; Cell Line, Tumor; Crystallography, X-Ray; Cyclin-Dependent Kinase 2; Drug Design; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; Indicators and Reagents; Models, Molecular; Molecular Conformation; Naphthalenes; Oxidation-Reduction; Pyrroles; Tetrazolium Salts; Thiazoles | 2003 |
The structure of neuromelanin as studied by chemical degradative methods.
Topics: Aged; Aged, 80 and over; Dicarboxylic Acids; Female; Humans; Hydrogen Peroxide; Hydrolysis; Melanins; Molecular Structure; Oxidants; Oxidation-Reduction; Pyrroles; Substantia Nigra; Thiazoles; Tyramine | 2003 |
Diverse regulation of atrial natriuretic peptide secretion by serotonin receptor subtypes.
Topics: Adenylyl Cyclase Inhibitors; Alkaloids; Aminobenzoates; Animals; Atrial Natriuretic Factor; Benzophenanthridines; Benzothiazoles; Calcium; Carbazoles; Cyclic AMP-Dependent Protein Kinases; Depression, Chemical; Dose-Response Relationship, Drug; Heart; Heart Atria; Imines; Indoles; Isoquinolines; Ketanserin; Male; Myocytes, Cardiac; Neomycin; para-Aminobenzoates; Perfusion; Phenanthridines; Piperazines; Piperidines; Protein Kinase C; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT4; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Staurosporine; Sulfonamides; Thiazoles; Type C Phospholipases | 2003 |
Short lexitropsin that recognizes the DNA minor groove at 5'-ACTAGT-3': understanding the role of isopropyl-thiazole.
Topics: DNA; Hydrogen; Hydrophobic and Hydrophilic Interactions; Ligands; Models, Molecular; Netropsin; Nuclear Magnetic Resonance, Biomolecular; Nucleic Acid Conformation; Pyrroles; Thiazoles | 2004 |
SU5416 inhibited VEGF and HIF-1alpha expression through the PI3K/AKT/p70S6K1 signaling pathway.
Topics: Binding Sites; Blotting, Northern; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoblotting; Indoles; Luciferases; Neovascularization, Pathologic; Ovarian Neoplasms; Phosphatidylinositol 3-Kinases; Phosphorylation; Plasmids; Protein Binding; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyrroles; Ribosomal Protein S6 Kinases, 70-kDa; RNA; RNA, Messenger; Signal Transduction; Tetrazolium Salts; Thiazoles; Time Factors; Transcription Factors; Transcriptional Activation; Transfection; Up-Regulation; Vascular Endothelial Growth Factor A | 2004 |
3,4,5,3',5'-Pentabromo-2-(2'-hydroxybenzoyl)pyrrole: a potential lead compound as anti-Gram-positive and anti-biofilm agent.
Topics: Anti-Bacterial Agents; Biofilms; Drug Resistance, Bacterial; Gentian Violet; Gram-Positive Bacteria; Humans; Hydrocarbons, Brominated; Microbial Sensitivity Tests; Pyrroles; Tetrazolium Salts; Thiazoles | 2005 |
Novel 3-amino-2-hydroxy acids containing protease inhibitors. Part 1: Synthesis and kinetic characterization as aminopeptidase P inhibitors.
Topics: Amino Acids; Aminopeptidases; Animals; Binding Sites; Escherichia coli; Kinetics; Leucine; Proline; Protease Inhibitors; Pyrroles; Rats; Structure-Activity Relationship; Substrate Specificity; Thiazoles | 2005 |
Effects of statins on microglia.
Topics: Amyloid beta-Peptides; Animals; Atorvastatin; Cell Death; Cell Line; Cell Survival; Cytokines; Dose-Response Relationship, Drug; Drug Interactions; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-6; L-Lactate Dehydrogenase; Lipopolysaccharides; Microglia; Peptide Fragments; Pyrroles; Rats; Simvastatin; Statistics, Nonparametric; Tetrazolium Salts; Thiazoles | 2005 |
A synthetic NCAM-derived peptide, FGL, protects hippocampal neurons from ischemic insult both in vitro and in vivo.
Topics: Animals; Animals, Newborn; Brain Ischemia; Cell Count; Cells, Cultured; Drug Interactions; Glucose; Hippocampus; Hypoxia; Neural Cell Adhesion Molecules; Neurons; Neuroprotective Agents; Organ Culture Techniques; Phosphorylation; Propidium; Pyridinium Compounds; Pyrroles; Quaternary Ammonium Compounds; Rats; Rats, Wistar; Receptors, Fibroblast Growth Factor; Synapses; Tetrazolium Salts; Thiazoles; Time Factors | 2005 |
Functionalized magnesium organometallics as versatile intermediates for the synthesis of polyfunctional heterocycles.
Topics: Antipyrine; Combinatorial Chemistry Techniques; Esters; Furans; Heterocyclic Compounds; Imidazoles; Imines; Iodides; Magnesium; Models, Chemical; Nitriles; Organometallic Compounds; Pyridines; Pyrroles; Quinolines; Thiazoles; Thiophenes; Uracil | 2006 |
[(S)-gamma-(Arylamino)prolyl]thiazolidine compounds as a novel series of potent and stable DPP-IV inhibitors.
Topics: Administration, Oral; Animals; Dipeptidyl Peptidase 4; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Female; Humans; Injections, Intravenous; Male; Molecular Conformation; Nitriles; Pyrroles; Rats; Rats, Sprague-Dawley; Rats, Wistar; Stereoisomerism; Structure-Activity Relationship; Thiazoles | 2006 |
Conformational behavior of dimethyl 5-methyl-1H,3H-pyrrolo[1,2-c][1,3]thiazole-6,7-dicarboxylate 2,2-dioxide isolated in low-temperature matrixes.
Topics: Algorithms; Argon; Cold Temperature; Esters; Isomerism; Krypton; Molecular Structure; Pyrroles; Spectroscopy, Fourier Transform Infrared; Thermodynamics; Thiazoles; Xenon | 2006 |
Pharmacy benefit spending on oral chemotherapy drugs.
Topics: Administration, Oral; Ambulatory Care; Antineoplastic Agents; Benzamides; Benzenesulfonates; Capecitabine; Dasatinib; Deoxycytidine; Drug Costs; Employer Health Costs; Erlotinib Hydrochloride; Fluorouracil; Gefitinib; Health Benefit Plans, Employee; Humans; Imatinib Mesylate; Indoles; Insurance, Pharmaceutical Services; Lenalidomide; Neoplasms; Niacinamide; Phenylurea Compounds; Piperazines; Prescription Fees; Pyridines; Pyrimidines; Pyrroles; Quinazolines; Sorafenib; Sunitinib; Thalidomide; Thiazoles; United States | 2006 |
A novel N-alkylated prodigiosin analogue induced death in tumour cell through apoptosis or necrosis depending upon the cell type.
Topics: Alkenes; Alkylation; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Membrane Permeability; Cell Survival; Dactinomycin; Diploidy; DNA Fragmentation; DNA, Neoplasm; Enzyme Inhibitors; Lymphoma, T-Cell; Mice; Necrosis; Prodigiosin; Pyrroles; Rats; Sarcoma 180; Staurosporine; Tetrazolium Salts; Thiazoles | 2008 |
A small molecule pan-Bcl-2 family inhibitor, GX15-070, induces apoptosis and enhances cisplatin-induced apoptosis in non-small cell lung cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Survival; Cisplatin; Dose-Response Relationship, Drug; Drug Synergism; ErbB Receptors; Humans; Immunoprecipitation; Indoles; Lung Neoplasms; Neoplasm Proteins; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Tetrazolium Salts; Thiazoles | 2008 |
Influence of mineral amendment on disease suppressive activity of Pseudomonas fluorescens to Fusarium wilt of chickpea.
Topics: Antibiosis; Cicer; Copper; Fusaric Acid; Fusarium; Minerals; Phenols; Phloroglucinol; Plant Diseases; Pseudomonas fluorescens; Pyrroles; Salicylic Acid; Thiazoles; Zinc | 2009 |
Cycloaddition reactions of thiazolium azomethine ylides: application to pyrrolo[2,1-b]thiazoles.
Topics: Alkynes; Azo Compounds; Combinatorial Chemistry Techniques; Cyclization; Molecular Structure; Pyrroles; Thiazoles; Thiosemicarbazones | 2007 |
Pyrroloquinoline quinone prevents oxidative stress-induced neuronal death probably through changes in oxidative status of DJ-1.
Topics: Animals; Antioxidants; Ascorbic Acid; Blotting, Western; Cell Death; Cell Survival; Dose-Response Relationship, Drug; Female; Hydrogen Peroxide; Microtubule-Associated Proteins; Neurons; Oxidants; Oxidation-Reduction; Oxidative Stress; Oxidopamine; Pregnancy; Protein Binding; Protein Deglycase DJ-1; Pyrroles; Quinolines; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured; Vitamin E | 2008 |
Effect of the multitargeted tyrosine kinase inhibitors imatinib, dasatinib, sunitinib, and sorafenib on mitochondrial function in isolated rat heart mitochondria and H9c2 cells.
Topics: Adenosine Triphosphate; Animals; Benzamides; Benzenesulfonates; Cell Survival; Dasatinib; Dose-Response Relationship, Drug; Electron Transport; Galactose; Glucose; Imatinib Mesylate; Indoles; Male; Mitochondria, Heart; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Myocytes, Cardiac; Niacinamide; Oxidative Phosphorylation; Phenylurea Compounds; Piperazines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyridines; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Sorafenib; Sunitinib; Thiazoles | 2008 |
Therapeutic Drug Monitoring of the new targeted anticancer agents imatinib, nilotinib, dasatinib, sunitinib, sorafenib and lapatinib by LC tandem mass spectrometry.
Topics: Antineoplastic Agents; Benzamides; Benzenesulfonates; Chromatography, Liquid; Dasatinib; Drug Monitoring; Humans; Imatinib Mesylate; Indoles; Lapatinib; Neoplasms; Niacinamide; Phenylurea Compounds; Piperazines; Pyridines; Pyrimidines; Pyrroles; Quinazolines; Sorafenib; Sunitinib; Tandem Mass Spectrometry; Thiazoles | 2009 |
Atorvastatin prevents hippocampal cell death due to quinolinic acid-induced seizures in mice by increasing Akt phosphorylation and glutamate uptake.
Topics: Analysis of Variance; Animals; Atorvastatin; Cell Death; Complex Mixtures; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Heptanoic Acids; Hippocampus; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Male; Mice; Oncogene Protein v-akt; Phosphorylation; Pyrroles; Quinolinic Acid; Seizures; Tetrazolium Salts; Thiazoles; Tritium | 2009 |
A highly atom economic, chemo-, regio- and stereoselective synthesis and evaluation of spiro-pyrrolothiazoles as antitubercular agents.
Topics: Antitubercular Agents; Crystallography, X-Ray; Drug Resistance, Multiple, Bacterial; Molecular Conformation; Mycobacterium tuberculosis; Pyrroles; Spiro Compounds; Stereoisomerism; Thiazoles | 2010 |
Structures of human Bruton's tyrosine kinase in active and inactive conformations suggest a mechanism of activation for TEC family kinases.
Topics: Agammaglobulinaemia Tyrosine Kinase; Amino Acid Sequence; Crystallography, X-Ray; Dasatinib; Enzyme Activation; Humans; Molecular Sequence Data; Protein Conformation; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrimidines; Pyrroles; Thiazoles | 2010 |
Colony stimulating factor-1 receptor as a target for small molecule inhibitors.
Topics: Benzamides; Binding Sites; Carbazoles; Computer Simulation; Dasatinib; Drug Design; Furans; Humans; Hydrogen Bonding; Imatinib Mesylate; Indoles; Piperazines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Receptor, Macrophage Colony-Stimulating Factor; Staurosporine; Sunitinib; Thiazoles | 2010 |
Field trial for evaluating the effects on honeybees of corn sown using Cruiser and Celest xl treated seeds.
Topics: Agriculture; Alanine; Animals; Bees; Dioxoles; Environmental Exposure; Insecticides; Lethal Dose 50; Neonicotinoids; Nitro Compounds; Oxazines; Pyrroles; Seeds; Thiamethoxam; Thiazoles; Zea mays | 2010 |
Co-administration of NVP-AEW541 and dasatinib induces mitochondrial-mediated apoptosis through Bax activation in malignant human glioma cell lines.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; bcl-2-Associated X Protein; Cell Cycle; Cell Cycle Proteins; Cell Growth Processes; Cell Line, Tumor; Dasatinib; Drug Synergism; Fluorescent Antibody Technique; Glioblastoma; Humans; Mitochondria; Phosphorylation; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Signal Transduction; Thiazoles; Transfection | 2010 |
Effect of the tyrosine kinase inhibitors (sunitinib, sorafenib, dasatinib, and imatinib) on blood glucose levels in diabetic and nondiabetic patients in general clinical practice.
Topics: Aged; Antineoplastic Agents; Benzamides; Benzenesulfonates; Blood Glucose; Dasatinib; Diabetes Mellitus; Female; Humans; Hypoglycemia; Hypoglycemic Agents; Imatinib Mesylate; Indoles; Linear Models; Male; Middle Aged; Neoplasms; Niacinamide; Pennsylvania; Phenylurea Compounds; Piperazines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyridines; Pyrimidines; Pyrroles; Retrospective Studies; Risk Assessment; Risk Factors; Sorafenib; Sunitinib; Thiazoles; Time Factors; Treatment Outcome | 2011 |
Chiral 6-hydroxymethyl-1H,3H-pyrrolo[1,2-c]thiazoles: novel antitumor DNA monoalkylating agents.
Topics: Adenocarcinoma; Antineoplastic Agents, Alkylating; Breast Neoplasms; Cell Line, Tumor; Colorectal Neoplasms; DNA; Drug Screening Assays, Antitumor; Female; Humans; Melanoma; Pyrroles; Thiazoles | 2010 |
Statins regulate interleukin-1β-induced RANKL and osteoprotegerin production by human gingival fibroblasts.
Topics: Atorvastatin; Cell Culture Techniques; Cell Survival; Cells, Cultured; Coloring Agents; Culture Media, Serum-Free; Fibroblasts; Gingiva; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-1beta; Osteoprotegerin; Pyrroles; RANK Ligand; Simvastatin; Temperature; Tetrazolium Salts; Thiazoles; Time Factors | 2011 |
Susceptibility of adult mosquitoes to insecticides in aqueous sucrose baits.
Topics: Aedes; Animals; Anopheles; Culex; Culicidae; Drug Combinations; Female; Imidazoles; Insecticides; Ivermectin; Macrocyclic Compounds; Macrolides; Male; Mosquito Control; Neonicotinoids; Nitriles; Nitro Compounds; Oxazines; Permethrin; Pyrethrins; Pyrroles; Sucrose; Thiamethoxam; Thiazoles | 2011 |
[KIT and KIT: from biology to clinical use].
Topics: Antineoplastic Agents; Benzamides; Benzenesulfonates; Gastrointestinal Stromal Tumors; Humans; Imatinib Mesylate; Indoles; Niacinamide; Phenylurea Compounds; Piperazines; Piperidines; Prognosis; Protein Kinase Inhibitors; Proto-Oncogene Mas; Proto-Oncogene Proteins c-kit; Pyridines; Pyrimidines; Pyrroles; Sorafenib; Sunitinib; Thiazoles | 2012 |
Dual inhibition of SRC and Aurora kinases induces postmitotic attachment defects and cell death.
Topics: Antineoplastic Agents; Apoptosis; Aurora Kinase A; Aurora Kinases; Cell Adhesion; Cell Line, Tumor; Dasatinib; Female; Humans; Mitosis; Phosphorylation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrazoles; Pyrimidines; Pyrroles; src-Family Kinases; Thiazoles | 2012 |
Divergent actions by inhibitors of DP IV and APN family enzymes on CD4+ Teff cell motility and functions.
Topics: Animals; CD13 Antigens; CD4-Positive T-Lymphocytes; Cells, Cultured; Chemokine CXCL12; Chemotaxis; Dipeptidyl Peptidase 4; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Enzyme Inhibitors; Female; Humans; Hydroxamic Acids; Lymphocyte Activation; Lysine; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Pyrroles; Pyrrolidines; Thiazoles; Transgenes | 2011 |
Sunitinib induces apoptosis in pheochromocytoma tumor cells by inhibiting VEGFR2/Akt/mTOR/S6K1 pathways through modulation of Bcl-2 and BAD.
Topics: Angiogenesis Inhibitors; Animals; Antimetabolites, Antineoplastic; Apoptosis; bcl-Associated Death Protein; Blotting, Western; Bromodeoxyuridine; Cell Line, Tumor; Cell Proliferation; Coloring Agents; In Situ Nick-End Labeling; Indicators and Reagents; Indoles; Microarray Analysis; Oncogene Protein v-akt; PC12 Cells; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Rats; Ribosomal Protein S6 Kinases; RNA, Small Interfering; Signal Transduction; Sunitinib; Tetrazolium Salts; Thiazoles; TOR Serine-Threonine Kinases; Vascular Endothelial Growth Factor Receptor-2 | 2012 |
Characterization of kinase inhibitors using different phosphorylation states of colony stimulating factor-1 receptor tyrosine kinase.
Topics: Animals; Benzamides; Benzenesulfonates; Binding, Competitive; Cell Line; Dasatinib; Dose-Response Relationship, Drug; Humans; Imatinib Mesylate; Indazoles; Indoles; Kinetics; Niacinamide; Phenylurea Compounds; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Pyridines; Pyrimidines; Pyrroles; Receptor, Macrophage Colony-Stimulating Factor; Sorafenib; Spodoptera; Staurosporine; Sulfonamides; Sunitinib; Surface Plasmon Resonance; Thiazoles; Transfection | 2012 |
Evaluation of anti-inflammatory, anti-nociceptive, and anti-ulcerogenic activities of novel synthesized thiazolyl and pyrrolyl steroids.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Carrageenan; Disease Models, Animal; Edema; Inflammation; Pain; Pyrroles; Rats; Rats, Sprague-Dawley; Steroids; Stomach Ulcer; Thiazoles; Ulcer | 2011 |
Synthesis, anticancer activity and apoptosis inducing ability of bisindole linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates.
Topics: Antineoplastic Agents; Apoptosis; Benzodiazepines; Cell Cycle; Cell Line, Tumor; Cell Separation; Chemistry, Pharmaceutical; Diet; Drug Design; Flow Cytometry; Histone Deacetylase Inhibitors; Humans; Indoles; Inhibitory Concentration 50; Models, Chemical; Poly(ADP-ribose) Polymerases; Pyrroles; Tetrazolium Salts; Thiazoles; Time Factors | 2012 |
Inhibition of Bcl-2 improves effect of LCL161, a SMAC mimetic, in hepatocellular carcinoma cells.
Topics: Animals; Antineoplastic Agents; Biomimetic Materials; Carcinoma, Hepatocellular; Down-Regulation; HEK293 Cells; Humans; Liver Neoplasms, Experimental; Male; Mice; Mice, Nude; Oligopeptides; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Thiazoles; Treatment Outcome; Xenograft Model Antitumor Assays | 2012 |
Synthesis and antimicrobial activity of some new hydrazone-bridged thiazole-pyrrole derivatives.
Topics: Anti-Bacterial Agents; Antifungal Agents; Bacteria; Dose-Response Relationship, Drug; Fungi; Hydrazones; Microbial Sensitivity Tests; Molecular Structure; Pyrroles; Structure-Activity Relationship; Thiazoles | 2013 |
Neuroprotective potential of atorvastatin and simvastatin (HMG-CoA reductase inhibitors) against 6-hydroxydopamine (6-OHDA) induced Parkinson-like symptoms.
Topics: Amphetamine; Analysis of Variance; Animals; Atorvastatin; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Enzyme-Linked Immunosorbent Assay; Glutathione; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-6; Male; Malondialdehyde; Mitochondria; Motor Activity; NADH Dehydrogenase; Nitrites; Oxidopamine; Parkinsonian Disorders; Pyrroles; Rats; Rats, Wistar; Simvastatin; Tetrazolium Salts; Thiazoles; Tumor Necrosis Factor-alpha | 2012 |
Lab reports and cat scans: can veterinary oncology guide our way to new treatments for human cancers?
Topics: Animals; Antineoplastic Agents; Benzamides; Breast Neoplasms; Cats; Disease Models, Animal; Dogs; Female; Humans; Imatinib Mesylate; Indoles; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mast-Cell Sarcoma; Neoplasms; Piperazines; Piperidines; Protein Kinase Inhibitors; Pyridines; Pyrimidines; Pyrroles; Thiazoles; Transcriptome | 2012 |
A regio- and stereoselective 1,3-dipolar cycloaddition for the synthesis of new-fangled dispiropyrrolothiazoles as antimycobacterial agents.
Topics: Anti-Bacterial Agents; Cyclization; Dose-Response Relationship, Drug; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Pyrroles; Stereoisomerism; Structure-Activity Relationship; Thiazoles | 2012 |
In-vitro growth inhibition of chemotherapy and molecular targeted agents in hepatocellular carcinoma.
Topics: Alanine; alpha-Fetoproteins; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Benzimidazoles; Carcinoma, Hepatocellular; Cetuximab; Dasatinib; Doxorubicin; Drug Screening Assays, Antitumor; Epothilones; Gefitinib; Humans; Indoles; Inhibitory Concentration 50; Liver Neoplasms; Niacinamide; Phenylurea Compounds; Piperidines; Pyridones; Pyrimidines; Pyrroles; Quinazolines; Sorafenib; Sunitinib; Thiazoles; Triazines | 2013 |
Chiral 6,7-bis(hydroxymethyl)-1H,3H-pyrrolo[1,2-c]thiazoles with anti-breast cancer properties.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Female; Humans; MCF-7 Cells; Models, Molecular; Molecular Structure; Pyrroles; Structure-Activity Relationship; Thiazoles | 2013 |
A combination strategy to inhibit Pim-1: synergism between noncompetitive and ATP-competitive inhibitors.
Topics: Adenosine Triphosphate; Antineoplastic Agents; Binding Sites; Binding, Competitive; Cell Line, Tumor; Cell Survival; Crystallography, X-Ray; Humans; Indoles; Kinetics; Molecular Docking Simulation; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-pim-1; Pyrroles; Recombinant Proteins; Structure-Activity Relationship; Thiazoles | 2013 |
Simultaneous analysis of anticancer agents bortezomib, imatinib, nilotinib, dasatinib, erlotinib, lapatinib, sorafenib, sunitinib and vandetanib in human plasma using LC/MS/MS.
Topics: Antineoplastic Agents; Benzamides; Boronic Acids; Bortezomib; Chromatography, Liquid; Dasatinib; Erlotinib Hydrochloride; Humans; Imatinib Mesylate; Indoles; Lapatinib; Niacinamide; Phenylurea Compounds; Piperazines; Piperidines; Pyrazines; Pyrimidines; Pyrroles; Quinazolines; Reproducibility of Results; Sorafenib; Sunitinib; Tandem Mass Spectrometry; Thiazoles | 2013 |
An atom economic synthesis and AChE inhibitory activity of novel dispiro 7-aryltetrahydro-1H-pyrrolo[1,2-c][1,3]thiazole and 4-aryloctahydroindolizine N-methylpiperidin-4-one hybrid heterocycles.
Topics: Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Electrophorus; Models, Molecular; Molecular Structure; Piperidines; Pyrroles; Structure-Activity Relationship; Thiazoles | 2013 |
New drugs 2013, part 2.
Topics: Acetanilides; Adrenergic beta-Agonists; Anti-Asthmatic Agents; Anti-Retroviral Agents; Bronchodilator Agents; Citrates; Crotonates; Drug Approval; Humans; Hydroxybutyrates; Immunosuppressive Agents; Laxatives; Nitriles; Organometallic Compounds; Peptides; Picolines; Piperidines; Pyrimidines; Pyrroles; Quinolones; Receptors, Guanylate Cyclase-Coupled; Thiazoles; Toluidines; Tropanes | 2013 |
Licofelone abolishes survival of carcinogenic fibroblasts by inducing apoptosis.
Topics: Analysis of Variance; Animals; Apoptosis; Cell Transformation, Neoplastic; DNA Primers; Dose-Response Relationship, Drug; Embryo, Mammalian; Fibroblasts; Flow Cytometry; Fluorouracil; Pyrroles; Rats; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Tetrazolium Salts; Thiazoles; Time Factors; Trypan Blue; Tumor Cells, Cultured | 2014 |
Selecting tyrosine kinase inhibitors for gastrointestinal stromal tumor with secondary KIT activation-loop domain mutations.
Topics: Amino Acid Motifs; Animals; Antineoplastic Agents; Benzamides; Chlorocebus aethiops; COS Cells; Dasatinib; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Gastrointestinal Neoplasms; Gastrointestinal Stromal Tumors; Humans; Hydrogen Bonding; Imatinib Mesylate; Indoles; Molecular Docking Simulation; Mutation, Missense; Piperazines; Protein Binding; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Pyrimidines; Pyrroles; Sunitinib; Thiazoles | 2013 |
Impact of P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) gene dosage on plasma pharmacokinetics and brain accumulation of dasatinib, sorafenib, and sunitinib.
Topics: Animals; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Brain; Dasatinib; DNA, Complementary; Female; Gene Dosage; Half-Life; Indoles; Male; Maternal-Fetal Exchange; Mice; Mice, Knockout; Niacinamide; Phenylurea Compounds; Pregnancy; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrimidines; Pyrroles; Real-Time Polymerase Chain Reaction; RNA; Sex Characteristics; Sorafenib; Sunitinib; Thiazoles | 2013 |
Cytotoxic properties of sunitinib and sorafenib on human corneal epithelial cells.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biomarkers; Cell Line; Cell Survival; Enzyme-Linked Immunosorbent Assay; Epithelium, Corneal; Humans; Immunohistochemistry; Indoles; Membrane Proteins; Microscopy, Fluorescence; Microscopy, Phase-Contrast; Neoplasm Proteins; Niacinamide; Phenylurea Compounds; Protein Kinase Inhibitors; Pyrroles; Receptor, Platelet-Derived Growth Factor beta; Sorafenib; Sunitinib; Tetrazolium Salts; Thiazoles | 2014 |
A common rejection module (CRM) for acute rejection across multiple organs identifies novel therapeutics for organ transplantation.
Topics: Allografts; Animals; Atorvastatin; Biopsy; Cohort Studies; Dasatinib; Databases as Topic; Disease Models, Animal; Drug Approval; Electronic Health Records; Gene Expression Regulation; Gene Regulatory Networks; Graft Rejection; Graft Survival; Heart Transplantation; Heptanoic Acids; Humans; Kidney; Kidney Transplantation; Meta-Analysis as Topic; Mice; Mice, Inbred C57BL; Molecular Targeted Therapy; Organ Specificity; Pyrimidines; Pyrroles; Reproducibility of Results; Retrospective Studies; Thiazoles; Transplantation; United States; United States Food and Drug Administration | 2013 |
Proteomic strategy for probing complementary lethality of kinase inhibitors against pancreatic cancer.
Topics: Antineoplastic Agents; Benzamides; Cell Line, Tumor; Cell Survival; Dasatinib; Drug Screening Assays, Antitumor; Drug Synergism; Heme Oxygenase-1; Humans; Imatinib Mesylate; Indoles; Pancreatic Neoplasms; Piperazines; Protein Kinase Inhibitors; Proteome; Pyrimidines; Pyrroles; Spectrometry, Mass, Electrospray Ionization; Sunitinib; Tandem Mass Spectrometry; Thiazoles | 2013 |
Synthesis and antimicrobial activity of some novel hydrazide, benzochromenone, dihydropyridine, pyrrole, thiazole and thiophene derivatives.
Topics: Anti-Bacterial Agents; Antifungal Agents; Benzopyrans; Candida albicans; Dihydropyridines; Dose-Response Relationship, Drug; Escherichia coli; Hydrazones; Microbial Sensitivity Tests; Molecular Structure; Pyrroles; Staphylococcus aureus; Structure-Activity Relationship; Thiazoles; Thiophenes | 2013 |
Lack of dopamine D4 receptor affinity contributes to the procognitive effect of lurasidone.
Topics: Animals; Antipsychotic Agents; Callithrix; Cognition; Conditioning, Operant; Dopamine Agents; Dose-Response Relationship, Drug; Female; Isoindoles; Lurasidone Hydrochloride; Male; Mental Recall; Protein Binding; Pyridines; Pyrimidines; Pyrroles; Receptors, Dopamine D4; Thiazoles | 2014 |
Rapid identification of Keap1-Nrf2 small-molecule inhibitors through structure-based virtual screening and hit-based substructure search.
Topics: Active Transport, Cell Nucleus; Amides; Animals; Benzene Derivatives; Cell Nucleus; Computer Simulation; Databases, Chemical; Drug Design; Furans; Humans; Intracellular Signaling Peptides and Proteins; Kelch-Like ECH-Associated Protein 1; Molecular Docking Simulation; Naphthalenes; PC12 Cells; Protein Binding; Pyrroles; Rats; RNA, Messenger; Structure-Activity Relationship; Sulfonamides; Thiazoles | 2014 |
The phosphoinositide 3-kinase α selective inhibitor BYL719 enhances the effect of the protein kinase C inhibitor AEB071 in GNAQ/GNA11-mutant uveal melanoma cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Survival; Class I Phosphatidylinositol 3-Kinases; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Gene Silencing; GTP-Binding Protein alpha Subunits; GTP-Binding Protein alpha Subunits, Gq-G11; Humans; Melanoma; Mice; Mutation; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Pyrroles; Quinazolines; RNA Interference; Signal Transduction; Thiazoles; Tumor Burden; Uveal Neoplasms; Xenograft Model Antitumor Assays | 2014 |
A TGF-β receptor 1 inhibitor for prevention of proliferative vitreoretinopathy.
Topics: Animals; Cell Proliferation; Cell Transdifferentiation; Disease Models, Animal; Fibroblasts; Humans; Intravitreal Injections; Protein Serine-Threonine Kinases; Pyrazoles; Pyrroles; Rabbits; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Retinal Pigment Epithelium; Tenon Capsule; Tetrazolium Salts; Thiazoles; Vitreoretinopathy, Proliferative | 2014 |
Targeting triple-negative breast cancer cells with 6,7-bis(hydroxymethyl)-1H,3H-pyrrolo[1,2-c]thiazoles.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Cycle; Cell Death; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Female; Humans; MCF-7 Cells; Molecular Structure; Pyrroles; Structure-Activity Relationship; Thiazoles; Tumor Cells, Cultured | 2014 |
Important role of CYP2J2 in protein kinase inhibitor degradation: a possible role in intratumor drug disposition and resistance.
Topics: Benzamides; Carcinoma, Hepatocellular; Cell Line, Tumor; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1B1; Cytochrome P-450 CYP2J2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dasatinib; Hep G2 Cells; Humans; Imatinib Mesylate; Indoles; Liver Neoplasms; Niacinamide; Phenylurea Compounds; Piperazines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Reverse Transcriptase Polymerase Chain Reaction; Sorafenib; Sunitinib; Thiazoles | 2014 |
Cotargeting of epidermal growth factor receptor and PI3K overcomes PI3K-Akt oncogenic dependence in pancreatic ductal adenocarcinoma.
Topics: Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Carcinoma, Pancreatic Ductal; Cell Cycle; Cell Movement; Cell Proliferation; Drug Synergism; ErbB Receptors; Erlotinib Hydrochloride; Fluorescent Antibody Technique; Humans; Immunoenzyme Techniques; Mice; Mice, Inbred NOD; Mice, SCID; Pancreatic Neoplasms; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrimidines; Pyrroles; Quinazolines; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Thiazoles; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2014 |
Prevention of alcohol-heightened aggression by CRF-R1 antagonists in mice: critical role for DRN-PFC serotonin pathway.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Alcohol Drinking; Animals; Central Nervous System Agents; Central Nervous System Depressants; Dorsal Raphe Nucleus; Ethanol; Mice; Neural Pathways; Prefrontal Cortex; Pyridazines; Pyrimidines; Pyrroles; Receptor, Serotonin, 5-HT1A; Receptors, Corticotropin-Releasing Hormone; Self Administration; Serotonin; Serotonin 5-HT1 Receptor Agonists; Thiazoles | 2014 |
Optimization of pyrrolamide topoisomerase II inhibitors toward identification of an antibacterial clinical candidate (AZD5099).
Topics: Adenosine Triphosphatases; Amides; Animals; Anti-Bacterial Agents; Crystallography, X-Ray; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Mice; Mice, Knockout; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Pyrroles; Rats; Rats, Wistar; Staphylococcal Infections; Staphylococcus aureus; Structure-Activity Relationship; Thiazoles; Topoisomerase II Inhibitors | 2014 |
Neuroprotective effects of the anti-cancer drug sunitinib in models of HIV neurotoxicity suggests potential for the treatment of neurodegenerative disorders.
Topics: AIDS Dementia Complex; Animals; Antineoplastic Agents; Cyclin-Dependent Kinase 5; Dasatinib; Erlotinib Hydrochloride; Flavonoids; HIV Envelope Protein gp120; In Vitro Techniques; Indoles; Lapatinib; Mice; Mice, Transgenic; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Protein Kinase Inhibitors; Purines; Pyrimidines; Pyrroles; Quinazolines; Rats; Roscovitine; Sunitinib; Thiazoles | 2014 |
Functional characterization of BTK(C481S) mutation that confers ibrutinib resistance: exploration of alternative kinase inhibitors.
Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Antineoplastic Agents; B-Lymphocytes; Cell Line, Tumor; Cyclohexylamines; Dasatinib; Drug Resistance, Neoplasm; Female; Gene Expression; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Middle Aged; Mutation; Piperidines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrazoles; Pyrimidines; Pyrroles; RNA, Small Interfering; Signal Transduction; Structure-Activity Relationship; Thiazoles | 2015 |
Black bib size is associated with feather content of pheomelanin in male house sparrows.
Topics: Animals; Feathers; Male; Melanins; Pigmentation; Pyrroles; Sparrows; Thiazoles | 2014 |
Inhibition of c-Kit by tyrosine kinase inhibitors.
Topics: Aminopyridines; Antineoplastic Agents; Benzothiazoles; Biomarkers; Bone Marrow; Cell Line, Tumor; Clinical Trials as Topic; Dasatinib; fms-Like Tyrosine Kinase 3; Gene Expression; Hair; Hematopoietic Stem Cells; Humans; Indazoles; Leukemia, Myeloid, Acute; Niacinamide; Phenylurea Compounds; Pigmentation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Pyrimidines; Pyrroles; Sorafenib; Sulfonamides; Thiazoles | 2015 |
Synthesis and antiproliferative activity of thiazolyl-bis-pyrrolo[2,3-b]pyridines and indolyl-thiazolyl-pyrrolo[2,3-c]pyridines, nortopsentin analogues.
Topics: Apoptosis; Cell Proliferation; Dose-Response Relationship, Drug; G2 Phase; HCT116 Cells; Humans; Membrane Potential, Mitochondrial; Molecular Structure; Pyridines; Pyrroles; Thiazoles | 2015 |
3-[4-(1H-indol-3-yl)-1,3-thiazol-2-yl]-1H-pyrrolo[2,3-b]pyridines, nortopsentin analogues with antiproliferative activity.
Topics: Alkaloids; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Drug Design; G2 Phase; Halogenation; Humans; Imidazoles; Indoles; Membrane Potential, Mitochondrial; Methylation; Mitochondria; Molecular Structure; Neoplasms; Pyridines; Pyrroles; Resting Phase, Cell Cycle; Thiazoles | 2015 |
Identification of apoptosis signal-regulating kinase 1 (ASK1) inhibitors among the derivatives of benzothiazol-2-yl-3-hydroxy-5-phenyl-1,5-dihydro-pyrrol-2-one.
Topics: Antineoplastic Agents; Binding Sites; Enzyme Assays; High-Throughput Screening Assays; Humans; Hypoglycemic Agents; Immunologic Factors; MAP Kinase Kinase Kinase 5; Neuroprotective Agents; Protein Binding; Protein Kinase Inhibitors; Pyrroles; Recombinant Proteins; Small Molecule Libraries; Structure-Activity Relationship; Thiazoles; User-Computer Interface | 2015 |
Potential Role of Glycogen Synthase Kinase-3β in Regulation of Myocardin Activity in Human Vascular Smooth Muscle Cells.
Topics: Actins; Calcium-Binding Proteins; Calponins; Cell Differentiation; Cell Line; Gene Expression Regulation; Gene Knockout Techniques; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Membrane Proteins; Microfilament Proteins; Muscle Proteins; Myocytes, Smooth Muscle; Nuclear Proteins; Phosphoproteins; Promoter Regions, Genetic; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Recombinant Proteins; RNA, Small Interfering; Serine; Thiazoles; Threonine; Trans-Activators; Urea | 2016 |
Cascade bicyclizations of o-alkynyl aldehydes with thiazolium salts: a new access toward poly-functionalized indeno[2,1-b]pyrroles.
Topics: Aldehydes; Catalysis; Indenes; Methane; Models, Molecular; Pyrroles; Salts; Thiazoles | 2015 |
Structure-Based Design of a Small Molecule CD4-Antagonist with Broad Spectrum Anti-HIV-1 Activity.
Topics: Anti-HIV Agents; CD4 Antigens; Cell Fusion; Cell Line; HIV Envelope Protein gp120; HIV Reverse Transcriptase; HIV-1; Humans; Hydrogen Bonding; Models, Molecular; Molecular Conformation; Oxalates; Piperidines; Protein Conformation; Pyrroles; Receptors, CCR5; Receptors, CXCR4; Reverse Transcriptase Inhibitors; Stereoisomerism; Structure-Activity Relationship; Thiazoles; Virus Internalization | 2015 |
Immuno-modulating properties of saliphenylhalamide, SNS-032, obatoclax, and gemcitabine.
Topics: Amides; Antineoplastic Agents; Antiviral Agents; Cells, Cultured; Coinfection; Cytokines; Deoxycytidine; Gemcitabine; Humans; Immunity, Innate; Immunologic Factors; Indoles; Influenza A virus; Influenza, Human; Interferon-alpha; Lipopolysaccharides; Macrophages; Oxazoles; Phosphoproteins; Pyrroles; RNA, Viral; Salicylates; Thiazoles; Virus Replication | 2016 |
Formation scheme and antioxidant activity of a novel Maillard pigment, pyrrolothiazolate, formed from cysteine and glucose.
Topics: Antioxidants; Cyclization; Cysteine; Deoxyglucose; Glucose; Glycation End Products, Advanced; Isomerism; Pyrroles; Thiazoles | 2016 |
IAP antagonists sensitize murine osteosarcoma cells to killing by TNFα.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Baculoviral IAP Repeat-Containing 3 Protein; Bone Neoplasms; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Tumor; Cell Survival; Cyclohexanes; Dose-Response Relationship, Drug; Genetic Predisposition to Disease; HEK293 Cells; Humans; Inhibitor of Apoptosis Proteins; Mice, Knockout; Osteosarcoma; Phenotype; Pyrroles; Receptor-Interacting Protein Serine-Threonine Kinases; Retinoblastoma Protein; Signal Transduction; Thiazoles; TNF-Related Apoptosis-Inducing Ligand; Transfection; Triazoles; Tumor Necrosis Factor-alpha; Tumor Suppressor Protein p53; Ubiquitin-Protein Ligases | 2016 |
Corticotropin releasing factor type-1 receptor antagonism in the dorsolateral bed nucleus of the stria terminalis disrupts contextually conditioned fear, but not unconditioned fear to a predator odor.
Topics: Animals; Behavior, Animal; Conditioning, Classical; Corticotropin-Releasing Hormone; Emotions; Fear; Male; Odorants; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; Septal Nuclei; Thiazoles | 2016 |
Smac mimetic LCL161 overcomes protective ER stress induced by obatoclax, synergistically causing cell death in multiple myeloma.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Regulatory Proteins; Caspases; Cell Line, Tumor; Down-Regulation; Drug Resistance, Neoplasm; Drug Synergism; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Heat-Shock Proteins; Humans; Indoles; Intracellular Signaling Peptides and Proteins; Mitochondrial Proteins; Multiple Myeloma; Neoplasm Recurrence, Local; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Thiazoles; Unfolded Protein Response; Up-Regulation; X-Box Binding Protein 1 | 2016 |
Design, synthesis and evaluation of small molecule CD4-mimics as entry inhibitors possessing broad spectrum anti-HIV-1 activity.
Topics: Anti-HIV Agents; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Drug Design; HIV-1; Humans; Microbial Sensitivity Tests; Molecular Structure; Pyrroles; Small Molecule Libraries; Structure-Activity Relationship; Thiazoles | 2016 |
Regulation of kynurenine biosynthesis during influenza virus infection.
Topics: Animals; Antiviral Agents; Female; Gene Expression Regulation; Host-Pathogen Interactions; Humans; Immunologic Factors; Indoleamine-Pyrrole 2,3,-Dioxygenase; Indoles; Influenza A Virus, H1N1 Subtype; Interferons; Kynurenine; Lung; Macrophages; Metabolic Networks and Pathways; Mice; Mice, Inbred BALB C; Orthomyxoviridae Infections; Oxazoles; Oximes; Primary Cell Culture; Pyrroles; Sulfonamides; Thiazoles; Transcriptome; Tryptophan; Viral Nonstructural Proteins; Virus Replication | 2017 |
Synthesis of new spirooxindole-pyrrolothiazole derivatives: Anti-cancer activity and molecular docking.
Topics: Antineoplastic Agents; Cell Proliferation; Crystallography, X-Ray; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Indoles; K562 Cells; MCF-7 Cells; Models, Molecular; Molecular Structure; Pyrroles; Spiro Compounds; Structure-Activity Relationship; Thiazoles | 2017 |
Synthesis, Antiviral Potency, in Vitro ADMET, and X-ray Structure of Potent CD4 Mimics as Entry Inhibitors That Target the Phe43 Cavity of HIV-1 gp120.
Topics: Anti-HIV Agents; Biomimetic Materials; CD4 Antigens; Cell Line; Crystallography, X-Ray; HIV Envelope Protein gp120; HIV Infections; HIV-1; Humans; Molecular Docking Simulation; Molecular Targeted Therapy; Pyrroles; Structure-Activity Relationship; Thiazoles; Virus Internalization | 2017 |
Thiamethoxam Toxicity and Effects on Consumption Behavior in Orius insidiosus (Hemiptera: Anthocoridae) on Soybean.
Topics: Alanine; Anilides; Animals; Aphids; Dioxoles; Fungicides, Industrial; Glycine max; Heteroptera; Insecticides; Neonicotinoids; Nitro Compounds; Oxazines; Predatory Behavior; Pyrazoles; Pyrroles; Thiamethoxam; Thiazoles | 2017 |
Click Chemistry-Facilitated Structural Diversification of Nitrothiazoles, Nitrofurans, and Nitropyrroles Enhances Antimicrobial Activity against Giardia lamblia.
Topics: Anti-Infective Agents; Antiprotozoal Agents; Click Chemistry; Giardia lamblia; Nitrofurans; Parasitic Sensitivity Tests; Pyrroles; Structure-Activity Relationship; Thiazoles | 2017 |
An Electron-Transporting Thiazole-Based Polymer Synthesized Through Direct (Hetero)Arylation Polymerization.
Topics: Chemistry Techniques, Synthetic; Electron Transport; Electrons; Ketones; Molecular Weight; Polymers; Pyrroles; Solar Energy; Thermodynamics; Thiazoles | 2018 |
Pyrrolopyrimidine vs Imidazole-Phenyl-Thiazole Scaffolds in Nonpeptidic Dimerization Inhibitors of Leishmania infantum Trypanothione Reductase.
Topics: Imidazoles; Leishmania infantum; NADH, NADPH Oxidoreductases; Protein Interaction Domains and Motifs; Protein Multimerization; Protozoan Proteins; Pyrimidines; Pyrroles; Small Molecule Libraries; Thiazoles | 2019 |
Smac mimetics LCL161 and GDC-0152 inhibit osteosarcoma growth and metastasis in mice.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cyclohexanes; Disease Models, Animal; Humans; Magnetic Resonance Imaging; Mice; Neoplasms; Positron-Emission Tomography; Pyrroles; Thiazoles; Xenograft Model Antitumor Assays | 2019 |
Uptake and dissipation of metalaxyl-M, fludioxonil, cyantraniliprole and thiamethoxam in greenhouse chrysanthemum.
Topics: Alanine; Chrysanthemum; Dioxoles; Fungicides, Industrial; Guanidines; Humans; Insecticides; Neonicotinoids; ortho-Aminobenzoates; Pesticide Residues; Pesticides; Pyrazoles; Pyrroles; Soil; Soil Pollutants; Thiamethoxam; Thiazoles | 2020 |
Preclinical Optimization of gp120 Entry Antagonists as anti-HIV-1 Agents with Improved Cytotoxicity and ADME Properties through Rational Design, Synthesis, and Antiviral Evaluation.
Topics: Anti-HIV Agents; Caco-2 Cells; HEK293 Cells; HIV Envelope Protein gp120; Humans; Microbial Sensitivity Tests; Molecular Structure; Pyridines; Pyrroles; Structure-Activity Relationship; Thiazoles | 2020 |
Edoxaban's contribution to key endothelial cell functions.
Topics: Cell Adhesion; Cells, Cultured; Dose-Response Relationship, Drug; Factor Xa Inhibitors; Human Umbilical Vein Endothelial Cells; Humans; Leukocytes, Mononuclear; Pyridines; Pyrroles; Quinazolines; Thiazoles; Wound Healing | 2020 |
Improved HPLC Conditions to Determine Eumelanin and Pheomelanin Contents in Biological Samples Using an Ion Pair Reagent.
Topics: Animals; Chromatography, High Pressure Liquid; Dicarboxylic Acids; Epidermis; Hair; Humans; Indicators and Reagents; Ions; Melanins; Mice; Pyrroles; Thiazoles | 2020 |
Combined LIM kinase 1 and p21-Activated kinase 4 inhibitor treatment exhibits potent preclinical antitumor efficacy in breast cancer.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Drug Synergism; Female; Gene Expression Regulation, Neoplastic; Humans; Lim Kinases; MAP Kinase Signaling System; Mice; p21-Activated Kinases; Phosphorylation; Pyrazoles; Pyrroles; Thiazoles; Xenograft Model Antitumor Assays | 2020 |
A selective p53 activator and anticancer agent to improve colorectal cancer therapy.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cisplatin; Colorectal Neoplasms; Doxorubicin; Drug Discovery; Drug Synergism; Female; Fluorouracil; Gene Expression Regulation, Neoplastic; HCT116 Cells; Humans; Mice; Mice, Nude; Protein Binding; Pyrroles; Thiazoles; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays | 2021 |
Repressing MYC by targeting BET synergizes with selective inhibition of PI3Kα against B cell lymphoma.
Topics: Acetanilides; Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Class I Phosphatidylinositol 3-Kinases; Gene Expression Regulation, Neoplastic; Heterocyclic Compounds, 3-Ring; Histone Acetyltransferases; Humans; Lymphoma, B-Cell; Mice; Morpholines; Nerve Tissue Proteins; Phosphorylation; Piperazines; Proto-Oncogene Proteins c-myc; Pyrroles; Receptors, Cell Surface; Thiazoles; Xenograft Model Antitumor Assays | 2022 |
Novel Structural Hybrids of Pyrrole and Thiazole Moieties: Synthesis and Evaluation of Antibacterial and Antifungal Activities.
Topics: Anti-Bacterial Agents; Antifungal Agents; Candida albicans; Cyclization; Gram-Negative Bacteria; Gram-Positive Bacteria; Pyrroles; Thiazoles; Thiosemicarbazones | 2021 |
Screening the pandemic response box identified benzimidazole carbamates, Olorofim and ravuconazole as promising drug candidates for the treatment of eumycetoma.
Topics: Acetamides; Animals; Antifungal Agents; Ascomycota; Drug Discovery; Drug Evaluation, Preclinical; Fenbendazole; Madurella; Moths; Mycetoma; Neglected Diseases; Piperazines; Pyrimidines; Pyrroles; Thiazoles; Triazoles | 2022 |