pyrroles has been researched along with stallimycin in 80 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 41 (51.25) | 18.7374 |
| 1990's | 15 (18.75) | 18.2507 |
| 2000's | 21 (26.25) | 29.6817 |
| 2010's | 3 (3.75) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bruice, TC; He, GX; Lopez, V; Mei, HY | 1 |
| Haaf, T; Hoehn, H; Kausch, K; Köhler, J; Poot, M | 1 |
| Bell, SM; Dee, A; Smith, PJ; Sykes, H | 1 |
| Bella, JL; Del Castillo, P; Stockert, JC | 1 |
| Fujimoto, A; Huynh, KH; Lin, MS; Wilson, MG | 1 |
| Ghosh, PK; Ghosh, R; Guntur, RM; Mehta, R | 1 |
| De Stefano, GF; Ferrucci, L; Mezzanotte, R; Vanni, R | 1 |
| Abrisqueta, JA; Martín-Lucas, MA; Pérez-Castillo, A | 1 |
| Bühler, EM; Malik, NJ | 1 |
| Beerman, TA; McHugh, MM; Sigmund, RD; Woynarowski, JM | 1 |
| Barton, JK; Morii, T; Pyle, AM; Uchida, K | 1 |
| Pelton, JG; Wemmer, DE | 2 |
| Portugal, J; Waring, MJ | 1 |
| Breslauer, KJ; Chou, WY; Curry, J; Ferrante, R; Marky, LA; Remeta, DP; Snyder, JG; Zaunczkowski, D | 1 |
| Dervan, PB; Youngquist, RS | 1 |
| Datema, R; Grehn, L; Ragnarsson, U | 1 |
| Iashina, LN; Malygin, EG; Ponomareva, TA; Rechkunova, NI; Zinov'ev, VV | 1 |
| Ochi, H; Watanabe, S; Yamamoto, H | 1 |
| Hori, T; Murata, M; Takahashi, E | 1 |
| Fujimoto, A; Lin, MS; Wilson, MG; Zhang, A | 1 |
| Hori, T; Ishihara, T; Kaneko, Y; Minamihisamatsu, M; Murata, M; Takahashi, E | 1 |
| Halbrecht, I; Hart, J; Klar, D; Shabtai, F | 1 |
| Klevit, RE; Reid, BR; Wemmer, DE | 1 |
| Crothers, DM; Phillips, DR | 1 |
| Rubin, J; Sundaralingam, M | 1 |
| Rajalakshmi, S; Rao, RM; Sarma, DS | 1 |
| Rønne, M; Thust, R | 1 |
| Haaf, T; Schmid, M | 1 |
| Lakhotia, SC; Roy, JK | 2 |
| Magnusson, G; Nilsson, MG; Skarped, C | 1 |
| Dervan, PB; Hertzberg, RP; Van Dyke, MW | 1 |
| Wilkins, RJ | 1 |
| Dervan, PB; Van Dyke, MW | 1 |
| Beabealashvili, RS; Gottikh, BP; Grokhovsky, SL; Gursky, GV; Khorlin, AA; Krylov, AS; Mikhailov, MV; Nikitin, SM; Retchinsky, VO; Streltsov, SA; Surovaya, AN; Zasedatelev, AS; Zhuze, AL | 1 |
| Eriksson, B; Grehn, L; Oberg, B; Ragnarsson, U | 1 |
| Dunner, JA; Elias, S; Martin, AO; Traisman, ES; Traisman, HS | 1 |
| Bonifazio Razzini, A; Faccio Dolfini, S | 1 |
| De Fazio, G; Kudamatsu, M | 1 |
| Donlon, TA; Magenis, RE | 1 |
| Engel, W; Hungerford, DA; Poppen, A; Schmid, M | 1 |
| Bichacho, S; Halbrecht, I; Hart, J; Klar, D; Shabtai, F | 1 |
| Hirschhorn, K; Wisniewski, LP | 1 |
| Andersen, O; Eldridge, FE; Rønne, M; Thust, R | 1 |
| Anupyl'd, T; Lilles, Iu; Raukas, E; Riaim, T | 1 |
| Reinert, KE | 1 |
| Huang, L; Lown, JW; Quada, JC | 1 |
| Garbiras, BJ; Hartley, JA; Haskell, MK; Lee, M; Souhami, RL; Wyatt, MD | 1 |
| Fagan, PA; Hopkins, PB; Rink, SM; Sigurdsson, S; Spielmann, HP; Wemmer, DE | 1 |
| Bartulewicz, D; Bielawski, K; Krajewska, D; Rózański, A | 1 |
| Beerman, TA; Blaskó, A; Bruice, TC; Chiang, SY; Sengupta, D | 1 |
| Gorbunov, IuA; Riabinin, VA; Siniakov, AN | 1 |
| Gamper, HB; Kutiavin, IV; Lokhov, SG; Mayer, RB; Riabinin, VA; Seregin, SV; Siniakov, AN | 1 |
| Bartulewicz, D; Markowska, A; Pućkowska, A; Rózański, A | 1 |
| Asai, A; Ashizawa, T; Kakita, S; Mihara, A; Mizukami, T; Nakano, H; Ochiai, K; Ogawa, H; Sakai, Y; Yamashita, Y | 1 |
| Fujiwara, T; Saito, I; Sugiyama, H; Tao, ZF | 1 |
| Lown, JW; Sharma, SK; Tandon, M | 1 |
| Hashimoto, S; Inui, T; Nakamura, Y | 1 |
| Denny, WA | 1 |
| Bruice, TW; Gonzalez, C; Moore, M; Ribeiro, S; Schmitz, U; Schroth, GP; Turin, L | 1 |
| Bhattacharya, S; Thomas, M | 1 |
| Fen Zhao, Y; Jin Zhu, C; Liu, D; Liu, Y; Tang, F; Wang, J; Yuan, G | 1 |
| Ikariyama, Y; Kuwabara, T; Noda, T; Ohtake, H; Ohtake, T; Toyama, S | 1 |
| Baird, EE; Bürli, RW; Duan, JX; Ge, Y; Gross, MI; Hu, W; Johnson, KW; Kaizerman, JA; Moser, HE; Tanaka, RD; White, S | 1 |
| Blanco, JB; Castedo, L; Martinez-Costas, J; Mascareñas, JL; Vázquez, ME | 1 |
| Baraldi, PG; Bianchi, N; Borgatti, M; Boschetti, S; Feriotto, G; Finotti, A; Gambari, R; Jeang, KT; Mischiati, C; Romagnoli, R; Sereni, A | 1 |
| Broggini, M; Fontana, E; Fowst, C; Geroni, C; Marchini, S; Moneta, D | 1 |
| Baraldi, PG; Beria, I; Caldarelli, M; Cozzi, P; Geroni, C; Marchini, S; Mongelli, N; Romagnoli, R | 1 |
| Schepers, U; Schmitz, K | 1 |
| Bratwall, C; Brown, T; Ellervik, U; Fox, KR; James, PL; Le Strat, L; Nordén, B | 1 |
| Baraldi, PG; Fruttarolo, F; Preti, D; Romagnoli, R; Tabrizi, MA | 1 |
| Bailey, SL; Bruce, CD; Buchmueller, KL; Davis, ZS; Hartley, JA; Lee, M; Matthews, DA; O'Hare, C; Register, JK; Taherbhai, ZT | 1 |
| Baldeyrou, B; Benzschawel, K; David-Cordonnier, MH; Hildebrand, MP; Keuser, C; Lansiaux, A; Lemster, T; Pindur, U | 1 |
| Blackmon, K; Brown, T; Hartley, JA; Jones, J; Lee, M; Mackay, H; Nguyen, B; O'Hare, CC; Uthe, P; Wilson, WD | 1 |
| Bando, T; Kashiwazaki, G; Minoshima, M; Nishijima, S; Shinohara, K; Sugiyama, H | 1 |
| Baraldi, PG; Cruz-Lopez, O; Lopez-Cara, C; Preti, D; Romagnoli, R | 1 |
| Bashkin, JK; Edwards, TG; Fisher, C; Fok, K; Helmus, M; Koeller, KJ; Slomczynska, U | 1 |
| Comin, MJ; Gallo, M; Krajewski, K; Wetzler, DE | 1 |
| Deng, Z; Hao, C; Huang, S; Yu, Y; Zhao, C | 1 |
5 review(s) available for pyrroles and stallimycin
| Article | Year |
|---|---|
DNA minor groove alkylating agents.
Topics: Alkylating Agents; Animals; Anthramycin; Antibiotics, Antineoplastic; Benzofurans; Bisbenzimidazole; Chlorambucil; Cyclohexanecarboxylic Acids; Cyclohexenes; Distamycins; DNA; Duocarmycins; Humans; Indoles; Netropsin; Nitrogen Mustard Compounds; Pyrroles; Structure-Activity Relationship | 2001 |
Brostallicin: a new concept in minor groove DNA binder development.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Clinical Trials, Phase I as Topic; Distamycins; DNA; Drug Combinations; Drug Evaluation, Preclinical; Drug Synergism; Glutathione; Glutathione Transferase; Guanidines; Humans; Molecular Structure; Neoplasms; Pyrroles | 2004 |
Polyamides as artificial transcription factors: novel tools for molecular medicine?
Topics: Animals; Distamycins; DNA; DNA-Binding Proteins; Gene Expression Regulation; Gene Expression Regulation, Developmental; Homeodomain Proteins; Humans; Imidazoles; Intercalating Agents; Nylons; Pyrroles; Transcription Factors; Transcription, Genetic; Up-Regulation; Zinc Fingers | 2004 |
Hybrid molecules between distamycin A and active moieties of antitumor agents.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Distamycins; DNA; Humans; Imidazoles; Molecular Structure; Nylons; Pyrroles; Stereoisomerism; Structure-Activity Relationship | 2007 |
alpha-halogenoacrylic derivatives of antitumor agents.
Topics: Animals; Antineoplastic Agents, Alkylating; Cell Line, Tumor; Distamycins; Guanidines; Humans; Mice; Pyrroles; Pyrroloiminoquinones | 2009 |
75 other study(ies) available for pyrroles and stallimycin
| Article | Year |
|---|---|
Rational design of substituted tripyrrole peptides that complex with DNA by both selective minor-groove binding and electrostatic interaction with the phosphate backbone.
Topics: Animals; Base Sequence; Cattle; Crystallography; Distamycins; DNA; DNA Damage; DNA, Superhelical; Drug Design; Hydrolysis; In Vitro Techniques; Models, Molecular; Molecular Sequence Data; Oligodeoxyribonucleotides; Peptides; Plasmids; Pyrroles | 1992 |
The minor-groove binding DNA-ligands netropsin, distamycin A and berenil cause polyploidisation via impairment of the G2 phase of the cell cycle.
Topics: Amidines; Bisbenzimidazole; Bromodeoxyuridine; Diminazene; Distamycins; DNA; Fibroblasts; Flow Cytometry; Guanidines; Humans; In Vitro Techniques; Interphase; Netropsin; Polyploidy; Pyrroles | 1990 |
Involvement of DNA topoisomerase II in the selective resistance of a mammalian cell mutant to DNA minor groove ligands: ligand-induced DNA-protein crosslinking and responses to topoisomerase poisons.
Topics: Amsacrine; Animals; Anthramycin; Benzimidazoles; Benzodiazepinones; Cell Line; Cell Survival; Distamycins; DNA; DNA Damage; DNA Topoisomerases, Type II; Doxorubicin; Drug Resistance; Intercalating Agents; Ligands; Mice; Mitoxantrone; Mutation; Nuclear Proteins; Pyrroles | 1990 |
DNA-induced distamycin A fluorescence.
Topics: Animals; Cattle; Chickens; Distamycins; DNA; Fluorescence; Polydeoxyribonucleotides; Pyrroles; Trypanosoma cruzi | 1990 |
Lack of specificity of DA/DAPI fluorescence.
Topics: Adult; Chromosome Aberrations; Chromosome Banding; Chromosomes, Human, Pair 10; Chromosomes, Human, Pair 13; Chromosomes, Human, Pair 15; Distamycins; Female; Fluorescent Dyes; Humans; Indoles; Infant; Intellectual Disability; Karyotyping; Male; Predictive Value of Tests; Pyrroles | 1990 |
Inhibition of heterochromatin condensation of human Y chromosome by distamycin-A.
Topics: Cells, Cultured; Distamycins; Female; Heterochromatin; Humans; Male; Pregnancy; Pyrroles; Y Chromosome | 1990 |
A possible correlation between DA-DAPI counterstaining and alu I-induced bands in fixed human chromosomes.
Topics: Chromosome Banding; Deoxyribonucleases, Type II Site-Specific; Distamycins; DNA Restriction Enzymes; Fixatives; Humans; Indoles; Metaphase; Pyrroles; Staining and Labeling | 1986 |
Evidence for lack of specificity of the DA/DAPI technique.
Topics: Adult; Distamycins; Humans; Indoles; Karyotyping; Male; Pyrroles; Staining and Labeling | 1987 |
DA/DAPI heteromorphisms in acrocentric chromosomes other than 15.
Topics: Chromosome Banding; Chromosomes, Human, Pair 13; Chromosomes, Human, Pair 14; Chromosomes, Human, Pair 21; Chromosomes, Human, Pair 22; Distamycins; Genetic Markers; Humans; Indoles; Pyrroles; Staining and Labeling | 1988 |
Effect of minor groove binding drugs on mammalian topoisomerase I activity.
Topics: Animals; Bisbenzimidazole; Distamycins; DNA, Superhelical; Electrophoresis, Agar Gel; Fluorescent Dyes; Indoles; Pyrroles; Topoisomerase I Inhibitors | 1989 |
High resolution footprinting of EcoRI and distamycin with Rh(phi)2(bpy)3+, a new photofootprinting reagent.
Topics: 2,2'-Dipyridyl; Autoradiography; Base Sequence; Binding Sites; Deoxyribonuclease EcoRI; Distamycins; DNA; Electrophoresis, Polyacrylamide Gel; Indicators and Reagents; Molecular Sequence Data; Organometallic Compounds; Photochemistry; Pyridines; Pyrroles; Rhodium; X-Ray Diffraction | 1989 |
Structural characterization of a 2:1 distamycin A.d(CGCAAATTGGC) complex by two-dimensional NMR.
Topics: Base Sequence; Chemical Phenomena; Chemistry; Distamycins; Magnetic Resonance Spectroscopy; Models, Molecular; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Protein Conformation; Pyrroles | 1989 |
Hydroxyl radical footprinting of the sequence-selective binding of netropsin and distamycin to DNA.
Topics: Base Composition; Base Sequence; Binding Sites; Distamycins; DNA, Bacterial; Edetic Acid; Escherichia coli; Ferric Compounds; Guanidines; Hydroxides; Hydroxyl Radical; Molecular Sequence Data; Netropsin; Pyrroles | 1987 |
Enthalpy-entropy compensations in drug-DNA binding studies.
Topics: Calorimetry; Daunorubicin; Distamycins; DNA; DNA Damage; Ethidium; Guanidines; Intercalating Agents; Netropsin; Nucleic Acid Conformation; Poly dA-dT; Pyrroles; Salts; Thermodynamics | 1987 |
Sequence-specific recognition of B-DNA by oligo(N-methylpyrrolecarboxamide)s.
Topics: Base Composition; Base Sequence; Binding Sites; Distamycins; DNA; Netropsin; Nucleic Acid Conformation; Pyrroles | 1985 |
Structure-activity relationships in distamycin A analogues: effect of alkyl groups on the pyrrole nitrogen at the non-amidine end of the molecule combined with methyl elimination in the following ring.
Topics: Antiviral Agents; Cell Survival; Chemical Phenomena; Chemistry, Physical; Distamycins; DNA, Viral; Humans; Pyrroles; Simplexvirus; Structure-Activity Relationship | 1986 |
[Nucleotide sequences in DNA showing preferential binding with distamycin A and acridine derivatives].
Topics: Aminoacridines; Base Sequence; Binding Sites; Distamycins; DNA; DNA Restriction Enzymes; In Vitro Techniques; Pyrroles | 1986 |
New heritable fragile site on chromosome 8 induced by distamycin A.
Topics: Adult; Chromosome Fragile Sites; Chromosome Fragility; Chromosomes, Human, Pair 8; Distamycins; Female; Humans; Male; Proto-Oncogenes; Pyrroles | 1988 |
Nature of distamycin A-inducible fragile sites.
Topics: Chromosome Banding; Chromosome Fragile Sites; Chromosome Fragility; Distamycins; Female; Genetic Markers; Humans; Karyotyping; Male; Neoplasms; Pedigree; Pyrroles; Tumor Cells, Cultured | 1988 |
Structural modeling of the distamycin A-d(CGCGAATTCGCG)2 complex using 2D NMR and molecular mechanics.
Topics: Base Composition; Calorimetry; Distamycins; Magnetic Resonance Spectroscopy; Mathematics; Models, Molecular; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Pyrroles | 1988 |
DA/DAPI-fluorescent heteromorphism of human Y chromosome.
Topics: Chromosome Banding; Distamycins; Fluorescent Dyes; Humans; Indoles; Karyotyping; Male; Polymorphism, Genetic; Pyrroles; Y Chromosome | 1988 |
Distamycin A-inducible fragile sites and cancer proneness.
Topics: Chromosome Fragile Sites; Chromosome Fragility; Disease Susceptibility; Distamycins; Female; Humans; Karyotyping; Male; Neoplasms; Pyrroles; Tumor Cells, Cultured | 1988 |
Familial fragile site found at the cancer breakpoint (1)(q32). Inducibility by distamycin A, concomitance with fragile (16)(q22).
Topics: Cells, Cultured; Chromosome Banding; Chromosome Fragile Sites; Chromosome Fragility; Chromosomes, Human, 1-3; Chromosomes, Human, 16-18; Distamycins; Female; Genetic Markers; Humans; Infant, Newborn; Intellectual Disability; Karyotyping; Male; Neoplasms; Pyrroles | 1986 |
1H NMR studies on the interaction between distamycin A and a symmetrical DNA dodecamer.
Topics: Base Sequence; Distamycins; DNA; Hydrogen; Magnetic Resonance Spectroscopy; Models, Molecular; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Pyrroles | 1986 |
Kinetics and sequence specificity of drug-DNA interactions: an in vitro transcription assay.
Topics: Base Sequence; Dactinomycin; Daunorubicin; Distamycins; DNA, Bacterial; Genes, Bacterial; Kinetics; Lac Operon; Plasmids; Promoter Regions, Genetic; Pyrroles; Transcription, Genetic | 1986 |
An unexpected major groove binding of netropsin and distamycin A to tRNA(phe).
Topics: Binding Sites; Distamycins; Guanidines; Models, Molecular; Molecular Structure; Netropsin; Nucleic Acid Conformation; Pyrroles; RNA, Fungal; RNA, Transfer, Amino Acid-Specific; RNA, Transfer, Phe; X-Ray Diffraction | 1984 |
Carcinogen-DNA interaction: differential effects of distamycin-a and spermine on the formation of 7-methylguanine in DNA by N-methyl-N-nitrosourea, methylmethanesulfonate, and dimethylsulfate.
Topics: Animals; Carcinogens; Distamycins; DNA; Drug Interactions; Guanine; Liver; Methyl Methanesulfonate; Methylation; Methylnitrosourea; Pyrroles; Rats; Spermine; Sulfuric Acid Esters | 1980 |
Structural modifications induced in Chinese hamster V79--E chromosomes by prefixation treatment in vitro with the AT-specific agents netropsin, distamycin A, and Hoechst 33258.
Topics: Animals; Benzimidazoles; Bisbenzimidazole; Chromosomes; Cricetinae; Cricetulus; Distamycins; Guanidines; Netropsin; Pyrroles | 1981 |
Distamycin A/DAPI bands and the effects of 5-azacytidine on the chromosomes of the chimpanzee, Pan troglodytes.
Topics: Animals; Azacitidine; Cells, Cultured; Chromosome Banding; Chromosomes; Distamycins; Fluorescent Dyes; Heterochromatin; Indoles; Karyotyping; Lymphocytes; Male; Pan troglodytes; Pyrroles | 1984 |
A-T specific DNA ligands and hypotonic induced supercondensation of chromocentre in brain cells of Drosophila nasuta larvae in relation to their synthetic activities.
Topics: Animals; Benzimidazoles; Bisbenzimidazole; Brain; Chromatin; Distamycins; DNA; Drosophila; Hypotonic Solutions; Pyrroles; RNA | 1984 |
Structure at restriction endonuclease MboI cleavage sites protected by actinomycin D or distamycin A.
Topics: Base Sequence; Binding Sites; Dactinomycin; Deoxyribonucleases, Type II Site-Specific; Distamycins; DNA Restriction Enzymes; DNA, Viral; Polyomavirus; Pyrroles | 1982 |
Map of distamycin, netropsin, and actinomycin binding sites on heterogeneous DNA: DNA cleavage-inhibition patterns with methidiumpropyl-EDTA.Fe(II).
Topics: Chemical Phenomena; Chemistry; Dactinomycin; Daunorubicin; Distamycins; DNA, Bacterial; Escherichia coli; Guanidines; Netropsin; Plasmids; Pyrroles; Structure-Activity Relationship | 1982 |
Selective binding of actinomycin D and distamycin A to DNA.
Topics: Adenoviruses, Human; Base Sequence; Chemical Phenomena; Chemistry; Dactinomycin; Distamycins; DNA Polymerase I; DNA Restriction Enzymes; DNA, Viral; Escherichia coli; Nucleic Acid Synthesis Inhibitors; Plasmids; Pyrroles | 1982 |
Footprinting with MPE.Fe(II). Complementary-strand analyses of distamycin- and actinomycin-binding sites on heterogeneous DNA.
Topics: Base Sequence; Dactinomycin; Distamycins; DNA; DNA Restriction Enzymes; Edetic Acid; Escherichia coli; Indicators and Reagents; Lac Operon; Nucleic Acid Conformation; Pyrroles | 1983 |
Synthetic sequence-specific ligands.
Topics: Amides; Base Sequence; Chemical Phenomena; Chemistry; Distamycins; DNA; Guanidines; Ligands; Models, Molecular; Netropsin; Oligopeptides; Polydeoxyribonucleotides; Pyrroles; Repressor Proteins; Structure-Activity Relationship; Transcription, Genetic | 1983 |
Synthesis and antiviral activity of distamycin A analogues: substitutions on the different pyrrole nitrogens and in the amidine function.
Topics: Animals; Cell Division; Cell Line; Chlorocebus aethiops; Distamycins; Indicators and Reagents; Kidney; Magnetic Resonance Spectroscopy; Mass Spectrometry; Nucleic Acid Synthesis Inhibitors; Pyrroles; Simplexvirus; Structure-Activity Relationship; Virus Replication | 1983 |
Effects of distamycin A & netropsin on condensation of mitotic chromosomes in early embryos & larval brain cells of Drosophila nasuta.
Topics: Animals; Brain; Chromosomes; Distamycins; Drosophila; Embryo, Nonmammalian; Female; Guanidines; Larva; Mitosis; Netropsin; Pyrroles | 1983 |
Enhancement of a fra(16)(q22) with distamycin A: a family ascertained through an abnormal proposita.
Topics: Abnormalities, Multiple; Child; Chromosome Fragile Sites; Chromosome Fragility; Chromosomes, Human, 16-18; Cleft Palate; Distamycins; Female; Genetic Techniques; Heart Defects, Congenital; Humans; Infant, Newborn; Male; Pyrroles | 1983 |
High resolution of heterochromatin of Drosophila melanogaster by distamycin A.
Topics: Animals; Distamycins; Drosophila melanogaster; Heterochromatin; Interphase; Male; Metaphase; Pyrroles | 1983 |
Inhibitory effect of Distamycin-A and a pyrazino-pyrazine derivative on tomato spotted wilt virus.
Topics: Antiviral Agents; Distamycins; Nicotiana; Plant Viruses; Plants, Toxic; Pyrazines; Pyrroles; Time Factors; Virus Replication | 1983 |
Methyl green is a substitute for distamycin A in the formation of distamycin A/DAPI C-bands.
Topics: Chromosome Banding; Distamycins; DNA; Heterochromatin; Humans; Methyl Green; Pyrroles; Rosaniline Dyes | 1983 |
The use of distamycin A in human lymphocyte cultures.
Topics: Cells, Cultured; Chemical Phenomena; Chemistry; Chromosome Banding; Chromosome Fragile Sites; Chromosome Fragility; Chromosomes, Human, 16-18; Distamycins; DNA; Dose-Response Relationship, Drug; Female; Heterochromatin; Humans; Karyotyping; Lymphocytes; Male; Pyrroles; Y Chromosome | 1984 |
Familial fragility on chromosome 16 (fra 16q22) enhanced by both interferon and Distamycin A.
Topics: Adult; Chromosome Fragile Sites; Chromosome Fragility; Chromosomes, Human, 16-18; Distamycins; Female; Humans; Interferon Type I; Karyotyping; Male; Metaphase; Pyrroles | 1983 |
Distamycin A-DAPI banding of nonfluorescent Y(Ynf) chromosomes in 45,X/46,XYnf mosaicism.
Topics: Adolescent; Centromere; Chromosome Banding; Distamycins; Female; Fluorescent Dyes; Genetic Markers; Humans; Indoles; Male; Mosaicism; Pyrroles; Turner Syndrome; Y Chromosome | 1982 |
The effect of in vitro distamycin A exposure on metaphase chromosome structure.
Topics: Animals; Cattle; Cells, Cultured; Chromosomes; Distamycins; Dose-Response Relationship, Drug; Humans; Karyotyping; Lymphocytes; Metaphase; Pyrroles | 1982 |
[hyperchromic spectra of DNA complexes with phenosafranine and distamycin A].
Topics: Chemical Phenomena; Chemistry; Coloring Agents; Distamycins; DNA; Mathematics; Phenazines; Pyrroles; Spectrophotometry; Temperature | 1980 |
Aspects of specific DNA-protein interaction; local bending of DNA molecules by in-register binding of the oligopeptide antibiotic distamycin.
Topics: Animals; Cattle; Distamycins; DNA; Macromolecular Substances; Mathematics; Nucleic Acid Conformation; Protein Binding; Protein Conformation; Pyrroles; Thymus Gland; Viscosity | 1981 |
Design, synthesis and sequence selective DNA cleavage of functional models of bleomycin--II. 1,2-trans-disubstituted cyclopropane units as novel linkers.
Topics: Antibiotics, Antineoplastic; Base Sequence; Bleomycin; Cross-Linking Reagents; Cyclopropanes; Distamycins; DNA; Drug Design; Histidine; Kinetics; Models, Molecular; Molecular Sequence Data; Pyrroles; Structure-Activity Relationship | 1995 |
Structure-activity relationship of a series of nitrogen mustard- and pyrrole-containing minor groove-binding agents related to distamycin.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Benzoates; Benzoic Acid; Binding Sites; Cattle; Cell Death; Chlorambucil; Circular Dichroism; Cross-Linking Reagents; Distamycins; DNA; Ethidium; Humans; Nitrogen Mustard Compounds; Plasmids; Poly dA-dT; Pyrroles; Structure-Activity Relationship; Tumor Cells, Cultured | 1994 |
An NMR study of [d(CGCGAATTCGCG)]2 containing an interstrand cross-link derived from a distamycin-pyrrole conjugate.
Topics: Base Sequence; Cross-Linking Reagents; Distamycins; DNA; Ligands; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Sequence Data; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Pyrroles | 1996 |
Synthetic analogues of netropsin and distamycin. II. Synthesis of a carbocyclic analogue of the pyrrolecarboxamide antitumour antibiotics.
Topics: Antiviral Agents; Benzene; Chemistry, Pharmaceutical; Chromatography, Thin Layer; Distamycins; Magnetic Resonance Spectroscopy; Molecular Structure; Netropsin; Pyrroles | 1995 |
A microgonotropen branched decaaza decabutylamine and its DNA and DNA/transcription factor interactions.
Topics: Animals; Bisbenzimidazole; Butylamines; Carrier Proteins; Cattle; Cell Cycle Proteins; Distamycins; DNA; DNA-Binding Proteins; E2F Transcription Factors; E2F1 Transcription Factor; Electrophoresis, Polyacrylamide Gel; Iron-Binding Proteins; Kinetics; Oligonucleotide Probes; Pyrroles; Retinoblastoma-Binding Protein 1; TATA Box; TATA-Box Binding Protein; Thymus Gland; Transcription Factor DP1; Transcription Factors; Transferrin-Binding Proteins; Zinc Fingers | 1997 |
[Sequence specific conjugates of minor groove ligands with inosine containing oligodeoxyribonucleotides].
Topics: Base Composition; Distamycins; DNA; Inosine Nucleotides; Ligands; Nucleic Acid Denaturation; Oligodeoxyribonucleotides; Pyrroles; Structure-Activity Relationship; Thermodynamics | 1997 |
[Selective stabilization of AT-rich DNA duplexes by oligodeoxyribonucleotide conjugates with distamycin analogues].
Topics: Distamycins; DNA; Ligands; Magnetic Resonance Spectroscopy; Nucleic Acid Denaturation; Oligodeoxyribonucleotides; Pyrroles; Thermodynamics | 1997 |
Synthetic analogues of netropsin and distamycin. IV. Synthesis of a new carbocyclic analogue of distamycin with alkylating side groups.
Topics: Alkylating Agents; Alkylation; Anti-Bacterial Agents; Antiviral Agents; Benzene; Distamycins; Netropsin; Nitrobenzoates; Pyrroles | 1997 |
Pyrronamycin A and B, novel antitumor antibiotics containing pyrrole-amide repeating unit, produced by Streptomyces sp.
Topics: Animals; Antibiotics, Antineoplastic; Antiviral Agents; Carcinoma; Distamycins; Fermentation; Humans; Lung Neoplasms; Mice; Mice, Nude; Microbial Sensitivity Tests; Pyrroles; Sarcoma 180; Streptomyces; Structure-Activity Relationship | 2000 |
Synthesis of pyrrole-imidazole-duocarmycin polyamide and its sequence selective DNA alkylation.
Topics: Alkylation; Dimerization; Distamycins; DNA; Imidazoles; Indicators and Reagents; Molecular Structure; Pyrroles | 1999 |
Design and synthesis of novel thiazole-containing cross-linked polyamides related to the antiviral antibiotic distamycin.
Topics: Antiviral Agents; Distamycins; DNA; DNA Topoisomerases, Type II; Magnetic Resonance Spectroscopy; Mass Spectrometry; Nylons; Oligopeptides; Pyrroles; Thiazoles; Topoisomerase II Inhibitors | 2000 |
Effect of polymethylene and phenylene linking groups on the DNA cleavage specificity of distamycin-linked hydroxamic acid-vanadyl complexes.
Topics: Animals; Cattle; Distamycins; DNA; DNA Fragmentation; Electrophoresis, Polyacrylamide Gel; Hydroxamic Acids; Plasmids; Polymers; Pyrroles; Vanadates | 2000 |
The hybridization-stabilization assay: a solution-based isothermal method for rapid screening and determination of sequence preference of ligands that bind to duplexed nucleic acids.
Topics: Base Pairing; Base Sequence; Binding, Competitive; Dactinomycin; Distamycins; DNA Footprinting; Drug Evaluation, Preclinical; Energy Transfer; Fluorescence; Intercalating Agents; Kinetics; Ligands; Netropsin; Nucleic Acid Hybridization; Nucleic Acids; Nylons; Oligonucleotides; Promoter Regions, Genetic; Pyrroles; Reproducibility of Results; Solutions; Substrate Specificity; Temperature; Thermodynamics | 2001 |
DNA binding properties of novel dansylated distamycin analogues in which the fluorophore is directly conjugated to the N-methyl-pyrrole.
Topics: Antiviral Agents; Circular Dichroism; Dansyl Compounds; Distamycins; DNA; Fluorescent Dyes; Kinetics; Models, Chemical; Peptide Biosynthesis; Peptides; Protein Binding; Protein Structure, Tertiary; Pyrroles; Sodium Chloride; Spectrometry, Fluorescence; Temperature | 2002 |
Electrospray ionization tandem mass spectrometric characteristics and fragmentation mechanisms of distamycin analogues.
Topics: Antiviral Agents; Distamycins; Imidazoles; Molecular Structure; Pyrroles; Spectrometry, Mass, Electrospray Ionization | 2002 |
Classification of DNA-binding mode of antitumor and antiviral agents by the electrochemiluminescence of ruthenium complex.
Topics: Antineoplastic Agents; Antiviral Agents; Cisplatin; Dactinomycin; Distamycins; DNA; Dose-Response Relationship, Drug; Duocarmycins; Electrochemistry; Indoles; Luminescent Measurements; Macromolecular Substances; Mitomycin; Molecular Structure; Pyrroles; Ruthenium | 2003 |
DNA binding ligands targeting drug-resistant bacteria: structure, activity, and pharmacology.
Topics: Animals; Anti-Bacterial Agents; Distamycins; DNA; Drug Resistance, Bacterial; Female; Gram-Positive Bacteria; Ligands; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Morpholines; Peritonitis; Pyrroles; Staphylococcal Infections; Staphylococcus aureus; Structure-Activity Relationship; Toxicity Tests, Acute | 2003 |
A synthetic miniprotein that binds specific DNA sequences by contacting both the major and the minor groove.
Topics: Amino Acid Sequence; Binding Sites; Crystallography, X-Ray; Distamycins; DNA; DNA-Binding Proteins; Models, Molecular; Molecular Sequence Data; Protein Conformation; Protein Kinases; Pyrroles; Recombinant Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Structure-Activity Relationship | 2003 |
Binding of hybrid molecules containing pyrrolo [2,1-c][1,4]benzodiazepine (PBD) and oligopyrrole carriers to the human immunodeficiency type 1 virus TAR-RNA.
Topics: Antiviral Agents; Benzodiazepines; Binding Sites; Cell Survival; Distamycins; HIV; HIV Long Terminal Repeat; Humans; Nuclear Proteins; Pyrroles; RNA, Viral; Transcription, Genetic; Tumor Cells, Cultured | 2004 |
Cytotoxic alpha-halogenoacrylic derivatives of distamycin A and congeners.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Distamycins; Drug Screening Assays, Antitumor; Female; Glutathione; Guanidines; Humans; Inhibitory Concentration 50; Mice; Mice, Nude; Neoplasm Transplantation; Pyrroles; Structure-Activity Relationship; Transplantation, Heterologous | 2004 |
Effects of a hairpin polyamide on DNA melting: comparison with distamycin and Hoechst 33258.
Topics: Base Pair Mismatch; Base Sequence; Binding Sites; Bisbenzimidazole; Deoxyribonuclease I; Distamycins; DNA; DNA Footprinting; Fluorescent Dyes; Ligands; Molecular Structure; Nucleic Acid Denaturation; Pyrroles; Thermodynamics | 2004 |
Physical and structural basis for the strong interactions of the -ImPy- central pairing motif in the polyamide f-ImPyIm.
Topics: Base Sequence; Binding Sites; Calorimetry; Circular Dichroism; Deoxyribonuclease I; Distamycins; DNA; DNA Footprinting; Imidazoles; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Nucleic Acid Denaturation; Nylons; Pyrroles; Thermodynamics | 2006 |
Design, synthesis and biological evaluation of new oligopyrrole carboxamides linked with tricyclic DNA-intercalators as potential DNA ligands or topoisomerase inhibitors.
Topics: Antineoplastic Agents; Cell Line, Tumor; Distamycins; DNA; DNA Footprinting; Drug Design; Humans; Intercalating Agents; Ligands; Molecular Structure; Netropsin; Pyrroles; Structure-Activity Relationship; Topoisomerase Inhibitors | 2007 |
Sequence recognition in the minor groove of DNA by covalently linked formamido imidazole-pyrrole-imidazole polyamides: effect of H-pin linkage and linker length on selectivity and affinity.
Topics: Antiviral Agents; Base Sequence; Binding Sites; Circular Dichroism; Deoxyribonuclease I; Dimerization; Distamycins; DNA; DNA Footprinting; Imidazoles; Kinetics; Models, Chemical; Molecular Sequence Data; Nucleic Acid Conformation; Nucleic Acid Denaturation; Pyrroles; Sensitivity and Specificity; Surface Plasmon Resonance; Temperature; Titrimetry | 2007 |
Cooperative alkylation of double-strand human telomere repeat sequences by PI polyamides with 11-base-pair recognition based on a heterotrimeric design.
Topics: Alkylating Agents; Alkylation; Base Pairing; Base Sequence; Cell Line; Distamycins; DNA; Humans; Imidazoles; Jurkat Cells; Nylons; Pyrroles; Repetitive Sequences, Nucleic Acid; Telomere | 2009 |
HPV episome levels are potently decreased by pyrrole-imidazole polyamides.
Topics: Antiviral Agents; Binding Sites; Bromodeoxyuridine; Cell Line, Tumor; Distamycins; DNA, Viral; Female; Human papillomavirus 16; Human papillomavirus 18; Human papillomavirus 31; Humans; Immunohistochemistry; Inhibitory Concentration 50; Microbial Sensitivity Tests; Nylons; Papillomavirus Infections; Plasmids; Pyrroles; Replication Origin; Uterine Cervical Neoplasms; Viral Load | 2011 |
New human papilloma virus E2 transcription factor mimics: a tripyrrole-peptide conjugate with tight and specific DNA-recognition.
Topics: Amino Acid Sequence; Antiviral Agents; Base Sequence; Biomimetic Materials; Distamycins; DNA-Binding Proteins; DNA, Viral; Human papillomavirus 16; Models, Molecular; Molecular Sequence Data; Oncogene Proteins, Viral; Papillomavirus Infections; Peptide Fragments; Protein Structure, Secondary; Pyrroles; Substrate Specificity | 2011 |
Mining of the pyrrolamide antibiotics analogs in Streptomyces netropsis reveals the amidohydrolase-dependent "iterative strategy" underlying the pyrrole polymerization.
Topics: Amides; Amidohydrolases; Anti-Bacterial Agents; Biocatalysis; Biological Products; Distamycins; Multigene Family; Netropsin; Polymers; Pyrroles; Streptomyces; Tandem Mass Spectrometry | 2014 |