Page last updated: 2024-08-18

pyrroles and semaxinib

pyrroles has been researched along with semaxinib in 396 studies

Research

Studies (396)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	4 (1.01)	18.2507
2000's	202 (51.01)	29.6817
2010's	158 (39.90)	24.3611
2020's	32 (8.08)	2.80

Authors

Authors	Studies
App, H; Fong, TA; Hirth, KP; Kim, YH; McMahon, G; Powell, TJ; Risau, W; Schreck, R; Shawver, LK; Sun, L; Tang, C; Ullrich, A; Wang, X	1
Bucana, CD; Davis, DW; Ellis, LM; Liu, W; McConkey, DJ; McMahon, G; Shaheen, RM; Wilson, MR; Zebrowski, BK	1
Angelov, L; Guha, A; McMahon, G; Roncari, L; Salhia, B	1
Ellis, LM; Liu, W; Shaheen, RM; Takahashi, Y	1
Hirth, KP; Menger, MD; Schilling, L; Schmiedek, P; Thurnher, A; Ullrich, A; Vajkoczy, P	1
Arastéh, K; Hannah, A	1
Harris, AL	1
Hoekman, K; Jorna, AS; Pinedo, HM; Smit, EF; Verheul, HM	1
Carter, SK	1
Cheson, BD; Conley, BA; Gore-Langton, RE	1
Garber, K	3
Fong, TA; Ge, S; Goldbrunner, R; Hirth, KP; Menger, MD; Rempel, SA; Schilling, L; Schmiedek, P; Tonn, JC; Ullrich, A; Vajkoczy, P; Vollmar, B	1
Blake, RA; Cherrington, JM; Ellis, LM; Hannah, AL; Laird, AD; Liang, C; Mendel, DB; Shaheen, RM; Shawver, LK; Smolich, BD; Weitman, S	1
Stephenson, J	1
Fong, TA; Hirth, KP; Menger, MD; Schilling, L; Schmiedek, P; Ullrich, A; Vajkoczy, P; Vollmar, B	1
Abman, SH; Gebb, S; Hirth, KP; Jakkula, M; Le Cras, TD; Tuder, RM; Voelkel, NF	1
Gore-Langton, RE; Pluda, JM; Via, LE	1
Antonian, L; Madan, A; Ogilvie, B; Parkinson, A; Shawver, LK; Shet, M; Wagner, G; Yang, C; Zhang, H	1
Abman, S; Hirth, PK; Kasahara, Y; Le Cras, TD; Taraseviciene-Stewart, L; Tuder, RM; Voelkel, NF; Waltenberger, J	1
Cherrington, JM; Li, G; Mendel, DB; Schreck, RE; Shawver, LK; Strawn, LM; Tanciongco, SS; Vasile, S; West, DC	1
Alger, L; Hirth, P; Kasahara, Y; Mc Mahon , G; Taraseviciene-Stewart, L; Tuder, RM; Voelkel, NF; Waltenberger, J	1
Albitar, M; Cherrington, JM; Giles, FJ; Smolich, BD; West, KA; Yuen, HA	1
Donnelly, E; Geng, L; Hallahan, DE; Lin, PC; McMahon, G; Oshinka, H; Sierra-Rivera, E	1
Honsawek, S; Kiewlich, D; Krystal, GW; Liang, C; Lipson, KE; McMahon, G; Sun, L; Vasile, S	1
Caldwell, RB; Ju, M; McMahon, G; Robinson, GS; Shih, SC; Smith, LE; Xu, X	1
Antonian, L; Haznedar, J; Yang, CY; Zhao, Y	1
Kuwano, M; Ono, M	1
Berdel, WE; Bieker, R; Büchner, T; Fiedler, W; Göner, M; Kelsey, S; Kreuter, M; Mesters, RM; Padró, T; Scigalla, P; Steins, M	1
Gelaw, B; Levin, S	1
Berger, NA; Berger, SJ; Dowlati, A; Gerson, SL; Haaga, J; Liu, L; Remick, SC; Spiro, TP; Willson, JK	1
Giles, FJ	2
Blaivas, M; Kish, PE; McMahon, G; Muraszko, KM; Ross, BD; Ross, DA; Strawderman, M	1
Kuno, T; Sasaki, M; Takamoto, T; Tamaki, N	1
Abman, SH	1
Antonian, L; Cropp, G; Hannah, A; Shawver, LK; Sukbuntherng, J; Wagner, GS	1
Harper, P; Khayat, D; Marx, GM; Pavlakis, N; Rixe, O; Steer, CB	1
Cropp, GF; Giaccone, G; Hoekman, K; Huisman, H; Kedde, MA; Kuenen, BC; Levi, M; Noordhuis, P; Parson, MR; Peters, GJ; Pinedo, HM; Rosen, L; Ruijter, R; Scigalla, P; Smit, EF; van der Vijgh, WJ	1
Blanke, CD; Corless, CL; Druker, BJ; Heinrich, MC	1
Beauchamp, RD; Hanley, GA; Roman, CD	1
Haspel, HC; McMahon, G; Scicli, AG; Scicli, GM	1
Bäckman, U; Christofferson, R; Jonsson, E; Larsson, R; Svensson, A	1
Aghakhani, N; Casadeval, N; Croisille, L; David, P; Eschwège, P; Gaudric, A; Hermine, O; Richard, S; Scigalla, P; Yvart, J	1
Beauchamp, RD; Choy, H; Johnson, D; Nanney, L; Parman, K; Riordan, C; Roman, CD	1
Dellian, M; Goetz, AE; Harris, AG; Krasnici, S; Messmer, K; Pahernik, S; Schmitt-Sody, M	1
Abman, SH; Le Cras, TD; Markham, NE; Tuder, RM; Voelkel, NF	1
Berlin, JD	1
Aiello, LP; Cahill, MT; Cavallerano, J; George, DJ; Hannah, AL; Kaelin, WG; Wong, JS	1
Cropp, G; Gosalia, R; Hannah, A; Sheldon, M; Stopeck, A; Vahedian, M	1
Hoekman, K; Kakkar, AK; Kostense, PJ; Kuenen, BC; Levi, M; Meijers, JC; Pinedo, HM; van Hinsbergh, VW	1
Hong, YS; Kim, HS; Lee, JH; Lee, JJ; Park, IY; Park, YJ	1
Cherrington, JM; Griffith, DJ; Heinrich, MC; McGreevey, LS; McMahon, G; O'Farrell, AM; Smolich, BD; Wait, CL; Yee, KW	1
Gómez, R; Pellicer, A; Remohí, J; Simón, C	1
Chu, E	1
Curran, WJ	1
Cherrington, J; Itokawa, T; Iwamoto, Y; Kuwano, M; McMahon, G; Nishioka, Y; Nokihara, H; Ono, M; Shibuya, M; Sone, S; Yamada, Y	1
Rosen, LS	1
Menger, MD; Schramm, R; Vajkoczy, P; Vollmar, B; Yamauchi, J	1
Barraja, P; Beall, HD; Bunderson, M; Moody, CJ; Newsome, JJ; Swann, E; Tooke, JE; Whatmore, JL	1
Ellis, LM	1
Cho, CY; Flores, SC; Kasahara, Y; Salvemini, D; Taraseviciene-Stewart, L; Tuder, RM; Voelkel, NF; Zhen, L	1
Alileche, A	1
Bachelot, T; Blay, JY; Jouanneau, E	1
Bailly, C; Lansiaux, A	1
Heryanto, B; Lipson, KE; Rogers, PA	1
Gallo, JM; Guo, P; Li, S; Ma, J; Reed, K	1
Albitar, M; Cherrington, JM; Cooper, MA; Cortes, JE; Giles, FJ; Hannah, AL; Hong, W; Kantarjian, HM; Karp, JE; Lancet, JE; Louie, SG; O'Brien, SM; O'Farrell, AM; Silverman, LR; Stopeck, AT; Verstovsek, S; Yuen, HA	1
Cherrington, JM; DePrimo, SE; Khatry, DB; Manning, WC; Nicholas, SL; O'Farrell, AM; Smolich, BD; Wong, LM	1
Albitar, M; Cherrington, JM; Cooper, MA; Garcia-Manero, G; Giles, FJ; Hannah, AL; Kantarjian, HM; Karp, JE; Khan, KD; Lancet, JE; Shami, PJ; Silverman, L; Stopeck, AT; Thomas, DA; Zangari, M	1
Alitalo, K; Eriksson, U; Ferrara, N; Hicklin, DJ; Lipson, KE; McMahon, G; Pepper, MS; Sleeman, JP; Tille, JC; Wang, X; Zhu, Z	1
Bergers, G; Bergsland, E; Hanahan, D; Meyer-Morse, N; Song, S	1
Baselga, J; Cavalli, F; Conte, PF; Deplanque, G; Harris, AL; Hoekman, K; Huisman, H; Kuenen, BC; Madhusudan, S; Pfanner, E; Scigalla, P; Seeber, S; Tabernero, J	1
Berkhof, J; Hoekman, K; Kakkar, AK; Kuenen, BC; Levi, M; Meijers, JC; Pinedo, HM; van Hinsbergh, VW	1
Fueller, T; Hummel, V; Rieckmann, P; Tonn, JC; Wagner, S	1
Li, QQ; Reed, E; Zhong, X	1
Erginay, A; Gaudric, A; Girmens, JF; Massin, P; Richard, S; Scigalla, P	1
Abdollahi, A; Debus, J; Hahnfeldt, P; Han, X; Hlatky, L; Howlett, AR; Huber, PE; Krempien, R; Lipson, KE; Trinh, T; Weber, KJ	1
Berdel, WE; Brega, NM; Cavalli, F; Duhrsen, U; Fiedler, W; Flasshove, M; Hossfeld, DK; Jacobs, M; Jung, W; Kuse, R; Loges, S; Mesters, R; O'Farrell, AM; Ottmann, OG; Scigalla, P; Serve, H; Staib, P; Thomalla, J; Tinnefeld, H	1
Bergers, G; Hanahan, D	1
Gong, H; Havers, W; Pöttgen, C; Schweigerer, L; Stüben, G; Stuschke, M	1
Barrios, RJ; Greenberg, NM; Huss, WJ	1
Avitto, FM; Beltrami, V; Cirolla, VA; Conte, S; Covotta, A; Covotta, L; Giarnieri, E; Luzzatto, L; Marino, G; Midiri, G; Vecchione, A	1
Bäckman, U; Christofferson, R; Svensson, A	1
Fujisawa, K; Hata, Y; Honda, M; Ishibashi, T; Sakamoto, T; Sassa, Y; Shiose, S; Takeda, A	1
Kuenen, BC	1
Braud, E; Duflos, M; Le Baut, G; Nourrisson, MR; Pfeiffer, B; Picot, C; Renard, P; Tonnerre, A; Tucker, G	1
Braud, E; Duflos, M; Le Baut, G; Pfeiffer, B; Renard, P; Tucker, G	1
Aleksic, A; Berg, S; Blaney, S; Dauser, R; McGuffey, L; Renbarger, J	1
Buckley, P; Doroshow, JH; Frankel, P; Galvin, I; Gandara, DR; Gosselin, R; Gumerlock, PH; Lara, PN; Lenz, HJ; Longmate, J; Mack, PC; Margolin, K; Meyers, FJ; Quinn, DI; Rao, J; Turrell, C; Valk, P; Wun, T	1
Inaba, T; Lee, C; Patterson, AV; Ramji, S; Riddick, DS	1
Cao, C; Choy, H; Freeman, ML; Morrow, JD; Saha, D; Sekhar, KR	1
Hallahan, DE; Tan, J	1
Erber, R; Groth, G; Hammes, HP; Katsen, AD; Kerger, H; Menger, MD; Thurnher, A; Ullrich, A; Vajkoczy, P	1
Abdollahi, A; Bischof, M; Debus, J; Grone, HJ; Hahnfeldt, P; Han, X; Hlatky, L; Huber, PE; Klenke, F; Krix, M; Lipson, KE; Poerschke, D; Roth, A; Sckell, A; Zieher, H	1
Voutsadakis, IA	1
Albitar, M; Anaissie, E; Cherrington, J; Cooper, M; Faderl, S; Garcia-Manero, G; Giles, FJ; Hannah, A; Kantarjian, H; Lancet, J; Morimoto, A; Stopeck, A; Tan, N; Zangari, M	1
Adams, C; Braybrooke, JP; Cattell, E; Deplanque, G; Frith, P; Harris, AL; Huson, SM; Madhusudan, S; Moore, N; Price, P; Scigalla, P; Taylor, M; Tsaloumas, MD	1
Ambler, CA; Bautch, VL; Chapman, DL; Hogan, KA	1
Kobayashi, S; Maru, Y; Nojima, Y; Sawano, A; Shibuya, M	1
Abman, SH; Kinsella, JP; Lin, YJ; Markham, NE; Maxey, A; McMurtry, IF; Tang, JR	1
Bönninghoff, R; Dono, R; Gretz, N; Keese, M; Magdeburg, R; Sturm, J; Vajkoczy, P; Zeller, R; Zhang, H	1
McGrath, P; Parng, C; Semino, C; Seng, WL	1
Fujisawa, K; Hata, Y; Ishibashi, T; Kubota, T; Noda, Y; Sassa, Y; Shiose, S; Takeda, A; Yoshikawa, H	1
Bautch, VL; Johnson, JH; Kearney, JB; Kumar, R; Roberts, DM; Rosenberg, MP	1
Dunn, L; Figg, WD; Fine, HA; Kim, S; Sparreboom, A; Tohnya, TM	1
Antonian, L; Sukbuntherng, J; Zhao, Y	1
Albitar, M; Cherrington, JM; Giles, FJ; Hannah, AL; Hong, W; Karp, JE; Lancet, JE; Louie, SG; O'Farrell, AM; Silverman, LR; Smolich, B; Stopeck, AT; Yuen, HA	1
Broxterman, HJ; Georgopapadakou, NH	1
Dellian, M; Eichhorn, ME; Strieth, S	1
Cao, D; Hoving, K; Karrison, T; Ryan, CW; Stadler, WM; Vogelzang, NJ; Vokes, EE; Wright, R	1
Kobayashi, K	1
Gajewski, TF; Karczmar, G; Medved, M; Peterson, AC; Stadler, WM; Swiger, S	1
Dignam, J; Gajewski, TF; Karczmar, G; Kindler, H; MacEneany, P; Medved, M; Mitchell, MT; Stadler, WM; Vokes, E; Yang, C	1
Ding, H; Hu, G; Li, QQ; Li, X; Neace, C; Reed, E; Wang, G; Zhao, J; Zhong, X; Zhu, Y	1
Chen, B; Larsen, SH; Li, CY; Sun, HB; Wang, SY; Xu, WX; Yang, RF; Yang, X; Yue, PB; Zhan, YQ; Zheng, H	1
Chakrabarti, S; Cukiernik, M; Downey, D; Evans, T; Hileeto, D; Mukherjee, S	1
Connors, S; Davis, DW; Demetri, GD; Desai, J; Fletcher, CD; Folkman, J; Goss, G; Harmon, D; Heymach, JV; Manola, J; McConkey, DJ; Quigley, T; Ryan, DP; Silverman, SG; Van den Abbeele, AD	1
Bevilacqua, G; Bocci, G; Boggi, U; Boschi, E; Campani, D; Danesi, R; Del Tacca, M; Esposito, I; Fasciani, A; Fioravanti, A; Marangoni, G; Mosca, F	1
Evan, GI; Fox, SB; Harris, AL; Knies-Bamforth, UE; Poulsom, R	1
Jiang, BH; Reed, E; Zheng, JZ; Zhong, XS	1
Abdollahi, A; Bischof, M; Debus, JU; Gong, P; Huber, PE; Lipson, KE; Stoffregen, C; Weber, KJ	1
Cooney, MM; Dowlati, A; Hoppel, CL; Ingalls, ST; Ivy, P; Ksenich, P; Lavertu, P; Makar, V; McCrae, K; McPeak, RJ; Overmoyer, B; Remick, S; Tserng, KY	1
Krystal, GW; Lipson, KE; Litz, J; Sakuntala Warshamana-Greene, G; Sulanke, G	1
Advani, AS	1
Burlison, J; Carbone, DP; Dikov, MM; Moghanaki, D; Nadaf, S; Ohm, JE; Ray, N; Tchekneva, EE	1
Bernsen, HJ; Bussink, J; Peeters, W; Schuuring, J; van Der Kogel, AJ	1
Abbruzzese, JL; Davis, DW; Demetri, GD; Herbst, RS; Heymach, JV; McConkey, DJ; Rashid, A; Raut, CP; Shen, Y; Stadler, WM; Takamori, R; Wen, S; Xiong, HQ	1
Angermayr, B; Bosch, J; Fernandez, M; Garcia-Pagan, JC; Mejias, M; Rodés, J	1
Cool, CD; Lee, JD; Sakao, S; Taraseviciene-Stewart, L; Voelkel, NF; Wood, K	2
de Wit, M; Fiedler, W; Höltje, J; Hossfeld, DK; Jacobs, MS; Laack, E; Schilling, G; Schuch, G; Scigalla, P	1
Sukbuntherng, J; Zhao, Y	1
du Manoir, J; Francia, G; Hicklin, DJ; Kerbel, RS; Ma, L; Rak, J; Viloria-Petit, A	1
Takagi, H; Watanabe, D	1
Kitano, S	1
Chowbay, B; Lye, KY; Moore, S; Olivo, M; Sharma, A; Zhou, Q	1
Taraseviciene-Stewart, L; Voelkel, N	1
Allen, FD; Dollé, JP; Lazarovici, P; Lelkes, PI; Rezvan, A	1
Elitzsch, A; Laschke, MW; Menger, MD; Vajkoczy, P; Vollmar, B	1
Charnsangavej, C; Ellis, LM; Kan, Z; Kobayashi, S; Lee, TY; Phongkitkarun, S; Tang, Y	1
Hu, Z; Johnsamuel, J; Lewis, A; Li, PK; Pandit, B; Sackett, DL; Sun, Y; Werbovetz, K; Xiao, Z	1
Aherne, W; Hannah, A; Hardcastle, A; Hayes, C; Judson, I; Kakkar, AJ; Leach, M; O'Donnell, A; Padhani, A; Phillips, S; Raynaud, F; Scurr, M; Trigo, JM; Workman, P	1
Ambrus, K; Herrmann, R; Pless, M; Rochlitz, C; Salzberg, M; Scigalla, P	1
Abdul-Karim, FW; Dowlati, A; Hartman, P; Ivy, P; Jesberger, J; Lewin, J; McCrae, K; Radivoyevitch, T; Remick, SC; Robertson, K; Waas, J; Wasman, JK; Ziats, NP	1
Rossi, H	1
Shenoy, N; Sistla, A	1
Antonian, L; Madan, A; Ogilvie, B; Parkinson, A; Sukbuntherng, J; Sweeny, D; Tan, W; Wong, S; Ye, C; Zhang, Q	1
Holmin, S; Risling, M; Sköld, MK	1
Abbruzzese, JL; Bogaard, K; Hoff, PM; Waldrum, S; Wolff, RA	1
Shenoy, N; Sistla, A; Yang, WL	1
Berghaus, A; Dellian, M; Eichhorn, ME; Jonczyk, A; Strieth, S; Sutter, A	1
Berdel, WE; Müller-Tidow, C; Serve, H; Tickenbrock, L	1
Bates, DO; Emmett, MS; Foster, RR; Harper, SJ; Joory, K; Mathieson, PW; Saleem, MA; Satchell, SC; Seckley, J; Xing, CY	1
Berlin, JD; Cropp, GF; Donnelly, E; Fleischer, AC; Hande, KR; Hannah, AL; Lockhart, AC; Rothenberg, ML; Schaaf, LJ; Schumaker, RD	1
Abraldes, JG; Groszmann, RJ; Haq, O; Iwakiri, Y; Loureiro-Silva, M; Sessa, WC	1
Böhmer, FD; Cénac, C; Dove, S; Eichhorn, E; Elz, S; Fischer, T; Heidel, F; Höcher, H; Hufsky, H; Mahboobi, S; Pongratz, H; Sellmer, A; Sicker, M; Stocking, C; Trümpler, A; Uecker, A	1
Beeram, M; Berg, K; de Bono, JS; Eckhart, SG; Forero, L; Hammond, LA; Izbicka, E; Mita, AC; Mita, MM; Patnaik, A; Rowinsky, EK; Simmons, P; Takimoto, C; Tolcher, AW; Weiss, GR	1
Gasparini, G; Longo, R; Sarmiento, R	1
Chung, HK; Hwang, JH; Jo, KW; Jo, YS; Jung, HS; Kim, DW; Kweon, GR; Lee, SJ; Park, KC; Park, SH; Rha, SY; Shong, M; Song, JH	1
Chen, P; Hu, Z; Lewis, A; Li, C; Li, PK; Pandit, B; Rich, W; Sackett, DL; Schaefer, K; Sun, Y	1
Aliff, T; Fleisher, M; Fury, MG; Gerald, W; Hann, L; Lis, E; Pfister, DG; Venkatraman, E; Wong, R; Zahalsky, A	1
Chen, S; Kanwar, YS; Pyagay, PE; Sung, SH; Wang, A; Ziyadeh, FN	1
Demura, Y; Scerbavicius, R; Taraseviciene-Stewart, L; Tuder, RM; Voelkel, NF	1
Ansiaux, R; Baudelet, C; Crokart, N; DeWever, J; Feron, O; Gallez, B; Grégoire, V; Jordan, BF; Martinive, P	1
Bain, J; Cazzaniga, S; Cleris, L; Formelli, F; Gambacorti-Passerini, C; Kuoni, T; Mologni, L; Puttini, M; Redaelli, S; Riva, B; Rostagno, R; Sala, E; Scapozza, L	1
Liu, G; Yang, TM	1
Gourgoulianis, KI; Kollia, P; Kostikas, K; Papaioannou, AI	1
Bernd, C; Miles, S; Noy, A; Politsmakher, A; von Roenn, J	1
Bokemeyer, C; Bruweleit, M; Butzal, M; Draab, E; Fiedler, W; Fischer, U; Hossfeld, DK; Jücker, M; Loges, S; Metzner, A; O'-Farrel, AM; Schuch, G; Tinnefeld, H	1
Denis, N; Dubreuil, P; Kosmider, O; Moreau-Gachelin, F	1
Blanche, EA; Colucci, MA; Maskell, L; Moody, CJ; Whatmore, JL	1
Cuneo, KC; Fu, A; Geng, L; Osusky, KL	1
Burns, N; Homma, N; Kraskauskas, D; McMurtry, IF; Morris, KG; Oka, M; Taraseviciene-Stewart, L; Voelkel, NF	1
Boackle, SA; Burns, N; Cool, C; Kraskauskas, D; Nicolls, MR; Parr, JE; Scerbavicius, R; Taraseviciene-Stewart, L; Voelkel, NF; Wood, K	1
Auersperg, N; Cosin, J; Dings, RP; Ramakrishnan, S; Schumacher, JJ; Subramanian, IV	1
Amura, CR; Brodsky, KS; Doctor, RB; Gattone, VH; Groff, R; Voelkel, NF	1
Caniggia, I; Groenman, FA; Post, M; Rutter, M; Tibboel, D; Wang, J	1
Grosicka, A; Grosicki, S; Hołowiecki, J	1
Chen, P; Edwards, PA; Guo, AM; Scicli, AG; Trick, G	1
Abman, SH; Balasubramaniam, V; Markham, N; Maxey, A; Seedorf, G; Tang, JR	1
Abdul-Karim, FW; Dowlati, A; Duerk, J; Fu, P; Hanks, S; Hartman, P; Hoppel, C; Ivy, P; Jesberger, JA; Lewin, J; McCrae, K; Overmoyer, B; Persons, M; Radivoyevitch, T; Remick, SC; Robertson, K; Shenk, R; Silverman, P; Wasman, JK; Ziats, NP	1
Ablonczy, Z; Crosson, CE	1
Abman, SH; Balasubramaniam, V; Kunig, AM; Muehlethaler, V; Seedorf, G	1
Alagkiozidis, I; Coukos, G; Gimotty, PA; Guo, W; Holtz, DO; Krafty, RT; Leiby, B; Mohamed-Hadley, A; Zhang, L	1
Audinot, JN; Caetano, B; Colin, IM; Feron, O; Gérard, AC; Poncin, S; Soncin, F; Sonveaux, P	1
Abdollahi, A; Debus, J; Hauser, K; Huber, PE; Lipson, KE; Roth, A; Timke, C; Weber, KJ; Zieher, H	1
Allegrini, G; Bocci, G; Danesi, R; Del Tacca, M; Di Paolo, A; Falcone, A; Fanelli, G; Fioravanti, A; Kerbel, RS; Naccarato, AG; Orlandi, P; Viacava, P	1
Lu, Q	1
Asai, T; Baba, K; Ida, T; Katanasaka, Y; Koizumi, F; Maeda, N; Oku, N; Shimizu, K	1
Chen, L; Feng, YL; Huang, XY; Li, WC; Li, YP; Liu, DS; Ou, XM; Wang, K; Wang, T; Wang, X; Wen, FQ; Zhang, SF	1
Banerjee, A; Blaney, S; Boyett, JM; Friedman, H; Fruscio, R; Geyer, R; Goldman, S; Kieran, MW; Kun, LE; Macdonald, T; Packer, R; Phillips, P; Pollack, I; Poussaint, TY; Supko, JG; Wallace, D	1
Bruns, AF; Howell, GJ; Mittar, S; Ponnambalam, S; Ulyatt, C; Walker, JH; Zachary, I	1
Carter, DE; Karlik, SJ; Roscoe, WA; Welsh, ME	1
Busby, B; Covington, J; Gu, JW; Johnson, JW; Young, E	1
Bailey, AP; Gu, JW; Manning, RD; Sartin, B; Shparago, M; Young, E	1
Herzog, W; Huisken, J; Müller, K; Stainier, DY	1
Budd, S; Byfield, G; Geisen, P; Hartnett, ME; Martiniuk, D	1
Amura, CR; Barry, NP; Brodsky, KS; Doctor, RB; McWilliams, RR	1
Ma, HB; Ning, YL; Qi, CJ; Qian, KQ; Wang, SZ; Zhang, XG	1
Agoston, DV; Lee, C	2
Cadamuro, M; Fabris, L; Fiorotto, R; Lecchi, S; Okolicsanyi, S; Somlo, S; Spirli, C; Strazzabosco, M; Tian, X	1
Choi, EJ; Choi, JP; Gho, YS; Hong, SW; Jeon, SG; Kim, YK; Kim, YS; Moon, HG; Oh, SY; Shin, TS; Zhu, Z	1
Bergmann, R; Kniess, T; Kuchar, M; Steinbach, J; Wuest, F	1
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Kowalewicz-Kulbat, M; Lawnicka, H; Melen-Mucha, G; Motylewska, E; Niedziela, A; Sicinska, P; Stepien, H	1
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Ghaskadbi, S; Krishnapati, LS	1
Alhussaini, AA; Cool, CD; Farkas, D; Farkas, L; Kraskauskas, D; Kraskauskiene, V; Natarajan, R; Nicolls, MR	1
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Hempel, C; Hoyer, N; Kurtzhals, JA; Staalsø, T	1
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Crucke, J; Huysseune, A	1
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Arien-Zakay, H; Lahiani, A; Lazarovici, P; Netzer, N; Ofir, R; Pinzur, L; Raveh, S; Yavin, E; Zahavi, E	1
Cagnon, VH; Hetzl, AC; Kido, LA; Montico, F	1
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Iqbal, Y; Malik, MF; Riaz, SK	1
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Liu, X; Sun, J; Wang, Q; Wang, R; Yu, K; Zhang, H	1
Bijli, KM; Carthan, KA; Green, DE; Hart, CM; Kang, BY; Kleinhenz, JM; Murphy, TC; Park, KK; Searles, CD; Sutliff, RL; Yeligar, SM	1
Gebreab, L; Graham, BB; Huber, KM; Kumar, R; Mickael, C; Perez, M; Sanders, L; Serkova, NJ; Smith-Jones, P; Tuder, RM	1
Chaudhary, KR; Courtman, DW; Deng, Y; Jiang, B; Stewart, DJ; Suen, C; Taha, M	1
Cho, I; Cho, SH; Jeong, YK; Jung, WG; Kim, EH; Kim, HD; Kim, J; Kim, MS; Lee, H; You, SH	1
Chai, CL; Ho, HK; Ngai, MH; So, CL; Sullivan, MB	1
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Cui, C; Hardwick, JC; Hawinkels, LJ; Heijkants, RC; Oudt, CH; Paauwe, M; Sier, CF; Theuer, CP; van Pelt, GW	1
Bezos, A; Kelso, MJ; Kirk, NS; Parish, CR; Ranson, M; Sudta, P; Suksamrarn, S; Willis, AC	1
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Jeong, YK; Jung, WG; Kim, EH; Lee, H	1
Alexeyev, M; Stevens, T; Townsley, MI; Voelkel, NF; Zhou, C	1
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Cvetanovic, M; Lin, W; Lin, Y; Pang, X; Stanojlovic, M; Stone, S	1
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Rivera-Delgado, E; von Recum, HA	1
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Bruegger, DE; Hoover, L; Jones, JW; Le, T; New, J; Tawfik, O; Thomas, SM; Usman, S; Yalamanchali, S	1
Kato, F; Nishimura, R; Sakao, S; Suzuki, T; Takeuchi, T; Tanabe, N; Tatsumi, K; Yasuda, T	1
Melnyk, O; Shults, NV; Suzuki, YJ; Zungu-Edmondson, M	1
Dean, A; Docherty, CK; Gregorc, T; Harvey, KY; MacLean, MR; Morrell, NW; Nilsen, M	1
Huang, MT; Lan, TH; Li, M; Song, JX; Wu, HL; Xu, DP	1
Del Zotto, H; Flores, LE; Gagliardino, JJ; Maiztegui, B; Román, CL	1
Kaur, B; Kaur, J; Singh, P	1
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Cho, S; Kim, E; Park, KW; Yang, J	1
Bigham, Z; Damarla, M; Huetsch, J; Jiang, H; Kliment, C; Servinsky, L; Shimoda, LA; Suresh, K; Yun, X	1
Strielkov, I; Weissmann, N	1
Dong, P; Wang, YH; Wu, JJ; Zhang, M; Zhu, XN	1
Barreira, B; Callejo, M; Cogolludo, A; Esquivel-Ruiz, S; Mondejar-Parreño, G; Morales-Cano, D; Moreno, L; Perez-Vizcaino, F	1
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Chen, D; Chen, G; Gao, P; Jia, D; Jing, ZC; Liu, G; Liu, J; Liu, Q; Lu, A; Qin, Z; Ruan, C; Shen, Y; Tang, J; Wang, XJ; Wang, Y; Ye, J; Yu, Y; Yuan, P; Zhang, J; Zhang, P; Zhou, Y; Zhu, Q; Zuo, C; Zuo, S	1
Bueno-Beti, C; Hadri, L; Hajjar, RJ; Sassi, Y	1
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Chaudhary, KR; Deng, Y; Mei, SHJ; Petersen, TH; Stewart, DJ; Suen, CM; Taha, M	1
Dygai, AM; Ermakova, NN; Ermolaeva, LA; Goldberg, VE; Khmelevskaya, ES; Krupin, VA; Pakhomova, AV; Pan, ES; Pershina, OV; Pozdeeva, AS; Rybalkina, OY; Skurikhin, EG; Skurikhina, VE; Vaizova, OE; Zhukova, MS	1
Vitali, SH	1
Fanburg, BL; Hill, NS; Penumatsa, KC; Warburton, RR	1
Bastarache, J; Blackwell, TS; Bloodworth, NC; Brittain, EL; Clark, CR; D'Amico, R; Gaskill, C; Gladson, S; Majka, SM; Merryman, WD; Moore, C; Scott, C; Shay, S; Snider, JC; Tanjore, H; West, JD	1
Bai, P; Fu, J; He, Y; Jia, D; Lyu, A; Lyu, L; Wan, N; Wan, Q; Yu, T; Zuo, C	1
Chesler, NC; Hacker, TA; Schmuck, EG; Schreier, DA; Wang, Z	1
Anderson, RF; Guise, CP; Kelso, MJ; Kirk, NS; Patterson, AV; Sansom, GN; Smaill, JB	1
Bisserier, M; Bridges, CR; Fargnoli, AS; Gubara, SM; Hadri, L; Hajjar, RJ; Katz, MG; Sassi, Y	1
Carman, BL; Machado, R; Predescu, DN; Predescu, SA	1
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Bai, P; Chen, Y; Fu, J; Li, F; Yu, T	1
Ghofrani, HA; Grimminger, F; Hadzic, S; Kojonazarov, B; Schermuly, RT; Seeger, W; Weissmann, N	2
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Damarla, M; Damico, RL; Hassoun, PM; Johnston, L; Kolb, TM; Peloquin, GL	1
Ghaskadbi, S; Turwankar, A	1
Bogaard, HJ; Chaudhary, KR; Hansmann, G; Legchenko, E; Stewart, DJ; Sun, XQ	1
Acoba, MG; Bigham, Z; Claypool, SM; Damarla, M; Huetsch, JC; Jiang, H; Kirsch, BJ; Kliment, C; Le, A; Servinsky, L; Shimoda, LA; Suresh, K; Zaldumbide, J	1
Chen, CY; Lan, SJ; Lan, YH; Lin, YJ; Sheu, MJ; Wang, CCN	1
Aliotta, JM; Borgovan, T; Brodsky, AS; Del Tatto, M; Dooner, MS; Goldberg, LR; Klinger, JR; Liang, OD; Pereira, M; Quesenberry, PJ; Ventetuolo, CE; Wen, S; Wu, KQ	1
Ackermann, M; Bogaard, HJ; Chaudhary, KR; Hansmann, G; Jonigk, DD; Kühnel, MP; Legchenko, E; Stewart, DJ; Sun, X	1
Abman, SH; Le Cras, TD	1
Beas-Zárate, C; Castañeda-Cabral, JL; Fajardo-Fregoso, BF; Ureña-Guerrero, ME	1
Ding, Y; Huang, W; Kong, H; Liu, P; Peng, L; Tan, Q; Wang, H; Wang, J; Wang, Y; Xie, W; Yang, M; Yu, M; Zhou, H	1
Chen, H; Chen, J; Chen, Y; Duan, X; He, W; Hou, C; Jiang, Q; Kuang, M; Li, Y; Liao, J; Liu, S; Lu, W; Luo, X; Tang, H; Wang, J; Yan, H; Yang, K; Zheng, Q; Zhou, Y; Zou, G	1
Butcher, EC; Dahms, P; Gandjeva, A; Granucci, E; Jiang, X; Nicolls, MR; Pasupneti, S; Semenza, GL; Tian, W; Tu, AB; Tuder, RM; Xiang, M	1
Bikou, O; Hadri, L; Hajjar, RJ; Sassi, Y	1
Bian, JS; Chen, J; Chen, Y; Dai, Y; Nie, X; Shen, C; Tan, J; Wang, W; Wu, Z; Yang, X; Ye, S	1
Bogaard, HJ; de Raaf, MA; Schalij, I	1
Fuchikami, C; Honda, Y; Kosugi, K; Kuramoto, K; Kuwano, K; Numakura, Y	1
Adão, R; Bialesova, L; Brás-Silva, C; Kinsella, BT; Mendes-Ferreira, P; Mulvaney, EP; Reid, HM	1
Alves, NJ; Kline, JA; Nallan Chakravarthula, T; Zagorski, J; Zeng, Z	1
Andersen, A; Andersen, S; Axelsen, JB; Bogaard, HJ; da Silva Goncalves Bos, D; de Man, FS; Gomez-Puerto, MC; Goumans, MJ; Kurakula, K; Pan, X; Peters, EL; Schalij, I; Schiepers, REJ; Sun, XQ; Szulcek, R; van der Laarse, WJ; Vonk Noordegraaf, A	1
Hayashi, T; Ijiri, Y; Imano, H; Kato, R	1
Kikuchi, N; Kurosawa, R; Miyata, S; Nakata, T; Nogi, M; Omura, J; Satoh, K; Satoh, T; Shimokawa, H; Shindo, T; Siddique, MAH; Sunamura, S; Takeuchi, Y	1
Higuchi, T; Inagaki, T; Masaki, T; Nakaoka, Y; Pearson, JT; Saito, S; Schwenke, DO; Shirai, M; Tsuchimochi, H; Umetani, K	1
Kawakami, E; Miwa, H; Naito, A; Sakao, S; Sanada, TJ; Shoji, H; Suda, R; Tanabe, N; Tatsumi, K	1
Banerjee, S; Clark, VR; Fishbein, G; Hong, J; Park, JF; Razee, A; Saddic, L; Umar, S; Williams, T	1
Hata, A; Kato, F; Kobayashi, T; Miwa, H; Nishimura, R; Sakao, S; Sanada, TJ; Shiina, Y; Suzuki, H; Tanabe, N; Tatsumi, K; Voelkel, N; Yoshino, I	1
Blankenberg, FG; Deuse, T; Fadel, E; Guihaire, J; Reichenspurner, H; Schrepfer, S; Spin, JM; Wang, D	1
Gupte, SA; Jacob, C; Jordan, A; Kitagawa, A; McMurtry, IF; Waddell, I	1
Awada, C; Bonnet, S; Boucherat, O; Bourgeois, A; Breuils-Bonnet, S; Grobs, Y; Lemay, SE; Nadeau, V; Orcholski, M; Paulin, R; Provencher, S; Romanet, C; Shimauchi, K; Toro, V; Tremblay, E	1
Ben-Batalla, I; Caruso, P; Gall, H; Ghofrani, HA; Götz, E; Grimminger, F; Herpel, S; Kojonazarov, B; Lepper, C; Loges, S; Manaud, G; Morrell, NW; Novoyatleva, T; Perros, F; Presser, N; Rai, N; Schermuly, RT; Seeger, W; Shihan, M; Upton, PD; Veeroju, S; Weissmann, N; Wharton, J; Wilkins, M	1
Arsalane, S; Guan, T; Jiang, SY; Jiang, X; Kim, D; Nicolls, MR; Pasupneti, S; Tamosiuniene, R; Tang, Q; Tian, W; Voelkel, NF	1
Chapman, RW; Chun, D; Cipolla, D; Corboz, MR; Gauani, H; Li, Z; Malinin, V; Perkins, WR; Plaunt, AJ	1
Bigby, TD; Breen, EC; Cannon, DT; Gilmore, NK; Gutierrez-Gonzalez, AK; Nogueira, L	1
Ishida, H; Ishii, R; Katsuragi, S; Kogaki, S; Narita, J; Ozono, K; Suginobe, H; Tsuru, H; Ueyama, A; Wang, R; Yoshihara, C	1
Akar, FG; Akar, JG; Bisserier, M; Cacheux, M; Fargnoli, A; Hadri, L; Hummel, JP; Katz, MG; Obus, E; Sassi, Y; Strauss, B	1
Chen, J; Dai, Y; Nie, X; Shen, C; Sun, H; Tan, J; Wang, W; Wu, Z; Yang, X	1
Hidaka, H; Maruyama, J; Maruyama, K; Naito, A; Sakao, S; Sanada, TJ; Shoji, H; Sumi, K; Tatsumi, K; Yoshida, Y; Zhang, E	1
Anderson, SA; Chen, LY; Danner, RL; Dougherty, EJ; Elinoff, JM; Gairhe, S; Johnston, KA; Lu, M; Mazer, AJ; Nelson, JNH; Noguchi, A; Siddique, MAH; Solomon, MA; Solomon, SB; Sun, J; Vanderpool, RR; Wang, H; Wang, S; Yu, ZX; Zou, Y	1

Reviews

33 review(s) available for pyrroles and semaxinib

Article	Year
The role of vascular endothelial growth factor (VEGF) in AIDS-related Kaposi's sarcoma. The oncologist, 2000, Volume: 5 Suppl 1 Topics: AIDS-Related Opportunistic Infections; Angiogenesis Inhibitors; Antiviral Agents; Endothelial Growth Factors; Enzyme Inhibitors; HIV-1; Humans; Indoles; Lymphokines; Neovascularization, Pathologic; Protein Isoforms; Protein-Tyrosine Kinases; Pyrroles; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Mitogen; Receptors, Vascular Endothelial Growth Factor; Sarcoma, Kaposi; Skin Neoplasms; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors	2000
von Hippel-Lindau syndrome: target for anti-vascular endothelial growth factor (VEGF) receptor therapy. The oncologist, 2000, Volume: 5 Suppl 1 Topics: Angiogenesis Inhibitors; Endothelial Growth Factors; Enzyme Inhibitors; Genes, Tumor Suppressor; Germ-Line Mutation; Humans; Indoles; Lymphokines; Neovascularization, Pathologic; Protein Isoforms; Protein-Tyrosine Kinases; Pyrroles; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Mitogen; Receptors, Vascular Endothelial Growth Factor; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; von Hippel-Lindau Disease	2000
Development of SU5416, a selective small molecule inhibitor of VEGF receptor tyrosine kinase activity, as an anti-angiogenesis agent. Anti-cancer drug design, 2000, Volume: 15, Issue:1 Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Enzyme Inhibitors; Humans; Indoles; Pyrroles; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor	2000
[Tumor angiogenesis and tumor angiogenesis inhibitors]. Gan to kagaku ryoho. Cancer & chemotherapy, 2001, Volume: 28, Issue:5 Topics: Angiogenesis Inhibitors; Angiostatins; Animals; Antigens, CD; Antineoplastic Agents; Cadherins; ErbB Receptors; Gefitinib; Humans; Indoles; Mice; Neoplasms; Oxindoles; Peptide Fragments; Plasminogen; Propionates; Pyrroles; Quinazolines; Vascular Cell Adhesion Molecule-1	2001
The vascular endothelial growth factor (VEGF) signaling pathway: a therapeutic target in patients with hematologic malignancies. The oncologist, 2001, Volume: 6 Suppl 5 Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal; Disease Progression; Endothelial Growth Factors; Enzyme Inhibitors; Hematologic Neoplasms; Humans; Indoles; Lymphokines; Matrix Metalloproteinases; Neovascularization, Pathologic; Protein-Tyrosine Kinases; Pyrroles; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors	2001
Bronchopulmonary dysplasia: "a vascular hypothesis". American journal of respiratory and critical care medicine, 2001, Nov-15, Volume: 164, Issue:10 Pt 1 Topics: Angiogenesis Inhibitors; Bronchopulmonary Dysplasia; Endothelial Growth Factors; Gene Expression Regulation, Developmental; Humans; Indoles; Infant, Newborn; Lymphokines; Proto-Oncogene Proteins; Pyrroles; Receptor Protein-Tyrosine Kinases; Respiration, Artificial; Respiratory Distress Syndrome, Newborn; Risk Factors; Signal Transduction; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factors	2001
Inhibition of KIT tyrosine kinase activity: a novel molecular approach to the treatment of KIT-positive malignancies. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2002, Mar-15, Volume: 20, Issue:6 Topics: Angiogenesis Inhibitors; Benzamides; Enzyme Inhibitors; Humans; Imatinib Mesylate; Indoles; Mutation; Neoplasms; Oxindoles; Piperazines; Propionates; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-kit; Pyrimidines; Pyrroles	2002
New drugs in acute myeloid leukemia. Current oncology reports, 2002, Volume: 4, Issue:5 Topics: Acute Disease; Adenine Nucleotides; Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antimetabolites, Antineoplastic; Antineoplastic Agents; Arabinonucleosides; Azacitidine; Bevacizumab; Boronic Acids; Bortezomib; Clofarabine; Cytosine; Decitabine; Dioxolanes; Humans; Indoles; Leukemia, Myeloid; Phthalazines; Pyrazines; Pyridines; Pyrroles; Thionucleotides	2002
Targeting vascular endothelial growth factor in colorectal cancer. Oncology (Williston Park, N.Y.), 2002, Volume: 16, Issue:8 Suppl 7 Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Biomarkers, Tumor; Camptothecin; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Colorectal Neoplasms; Disease-Free Survival; Endothelial Growth Factors; Female; Fluorouracil; Humans; Indoles; Irinotecan; Leucovorin; Male; Neovascularization, Pathologic; Prognosis; Pyrroles; Randomized Controlled Trials as Topic; Survival Analysis; Treatment Outcome	2002
New chemotherapeutic agents: update of major chemoradiation trials in solid tumors. Oncology, 2002, Volume: 63 Suppl 2 Topics: Alkyl and Aryl Transferases; Angiogenesis Inhibitors; Angiostatins; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Chemotherapy, Adjuvant; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose Fractionation, Radiation; Drugs, Investigational; Endothelial Growth Factors; Enzyme Inhibitors; Esophageal Neoplasms; Farnesyltranstransferase; Female; Head and Neck Neoplasms; Humans; Indoles; Intercellular Signaling Peptides and Proteins; Isoenzymes; Laryngeal Neoplasms; Lung Neoplasms; Lymphokines; Male; Membrane Proteins; Neoplasms; Peptide Fragments; Plasminogen; Prostaglandin-Endoperoxide Synthases; Prostatic Neoplasms; Pyrroles; Radiotherapy, Adjuvant; Randomized Controlled Trials as Topic; Treatment Outcome; Uterine Cervical Neoplasms; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors	2002
Inhibitors of the vascular endothelial growth factor receptor. Hematology/oncology clinics of North America, 2002, Volume: 16, Issue:5 Topics: Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Bevacizumab; Clinical Trials as Topic; Colorectal Neoplasms; Drug Design; Drug Screening Assays, Antitumor; Endothelial Growth Factors; Enzyme Inhibitors; Humans; Indoles; Intercellular Signaling Peptides and Proteins; Lymphokines; Neoplasm Proteins; Neoplasms; Neovascularization, Pathologic; Phthalazines; Piperidines; Pyridines; Pyrroles; Quinazolines; Recombinant Proteins; RNA, Catalytic; Treatment Failure; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2; Vascular Endothelial Growth Factors	2002
A targeted approach for antiangiogenic therapy of metastatic human colon cancer. The American surgeon, 2003, Volume: 69, Issue:1 Topics: Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal; Colonic Neoplasms; Colorectal Neoplasms; Endothelial Growth Factors; Extracellular Matrix; Humans; Indoles; Integrins; Intercellular Signaling Peptides and Proteins; Lymphokines; Neovascularization, Pathologic; Oxindoles; Propionates; Pyrroles; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors	2003
[Clinical development of anti-angiogenic agents in 2002]. Bulletin du cancer, 2003, Volume: 90, Issue:1 Topics: Angiogenesis Inhibitors; Antineoplastic Agents; Clinical Trials, Phase I as Topic; Collagen; Endostatins; Endothelial Growth Factors; Humans; Indoles; Intercellular Signaling Peptides and Proteins; Lymphokines; Neovascularization, Pathologic; Peptide Fragments; Pyrroles; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors	2003
Flt3 in acute myelogenous leukemia: biology, prognosis, and therapeutic implications. Medical oncology (Northwood, London, England), 2003, Volume: 20, Issue:4 Topics: Adult; Animals; Enzyme Inhibitors; fms-Like Tyrosine Kinase 3; Humans; Indoles; Leukemia, Myeloid, Acute; Mice; Middle Aged; Prognosis; Proto-Oncogene Proteins; Pyrroles; Randomized Controlled Trials as Topic; Receptor Protein-Tyrosine Kinases; Treatment Outcome	2003
Anti-vascular tumor therapy: recent advances, pitfalls and clinical perspectives. Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy, 2004, Volume: 7, Issue:2 Topics: Animals; Anti-HIV Agents; Drug Delivery Systems; Humans; Indoles; Neoplasms; Neovascularization, Pathologic; Protein Kinase Inhibitors; Pyrroles; Randomized Controlled Trials as Topic; Sunitinib	2004
[Lung cancer: molecular targeting therapy]. Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society, 2004, Volume: 42, Issue:5 Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Benzamides; Cetuximab; ErbB Receptors; Erlotinib Hydrochloride; Gene Targeting; Genetic Therapy; Humans; Imatinib Mesylate; Indoles; Lung Neoplasms; Piperazines; Pyrimidines; Pyrroles; Quinazolines; Receptor Protein-Tyrosine Kinases; Signal Transduction; Trastuzumab	2004
C-kit as a target in the treatment of acute myelogenous leukemia. Current hematology reports, 2005, Volume: 4, Issue:1 Topics: Acute Disease; Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Benzamides; Cell Line, Tumor; Clinical Trials as Topic; Hematopoiesis; Humans; Imatinib Mesylate; Indoles; Leukemia, Myeloid; Mice; Oxindoles; Piperazines; Propionates; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-kit; Pyrimidines; Pyrroles; Stem Cell Factor	2005
[Potential pharmacological treatments for diabetic retinopathy]. Nihon rinsho. Japanese journal of clinical medicine, 2005, Volume: 63 Suppl 6 Topics: Aldehyde Reductase; Antioxidants; Clinical Trials as Topic; Cyclooxygenase Inhibitors; Diabetic Retinopathy; Glycation End Products, Advanced; Growth Hormone; Guanidines; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Imidazolidines; Indoles; Maleimides; Octreotide; Oxygen Inhalation Therapy; Platelet Aggregation Inhibitors; Protein Kinase C; Pyrroles; Thiamine; Vascular Endothelial Growth Factor A	2005
[Medications for diabetic macular edema]. Nihon rinsho. Japanese journal of clinical medicine, 2005, Volume: 63 Suppl 6 Topics: Acetazolamide; Diabetic Retinopathy; Diagnostic Techniques, Ophthalmological; Humans; Indoles; Injections, Intralesional; Macular Edema; Maleimides; Prognosis; Protein Kinase C; Protein Kinase C beta; Pyrroles; Triamcinolone Acetonide; Vascular Endothelial Growth Factor A	2005
Emphysema: an autoimmune vascular disease? Proceedings of the American Thoracic Society, 2005, Volume: 2, Issue:1 Topics: Animals; Apoptosis; Autoantibodies; Autoimmune Diseases; Cell Proliferation; Endothelial Growth Factors; Glucocorticoids; Indoles; Methylprednisolone; Oxidative Stress; Protein Kinase Inhibitors; Pulmonary Emphysema; Pyrroles; Rats; Receptors, Vascular Endothelial Growth Factor	2005
Distribution, metabolism, and excretion of the anti-angiogenic compound SU5416. Toxicology in vitro : an international journal published in association with BIBRA, 2006, Volume: 20, Issue:2 Topics: Angiogenesis Inhibitors; Animals; Autoradiography; Biotransformation; Blood Proteins; Cytochrome P-450 Enzyme System; Drug Evaluation, Preclinical; Humans; Indoles; Injections, Intravenous; Protein Binding; Pyrroles; Species Specificity	2006
Emerging Flt3 kinase inhibitors in the treatment of leukaemia. Expert opinion on emerging drugs, 2006, Volume: 11, Issue:1 Topics: Animals; Antineoplastic Agents; Carbazoles; Clinical Trials as Topic; Drug Evaluation, Preclinical; Drug Therapy, Combination; fms-Like Tyrosine Kinase 3; Furans; Humans; Indoles; Leukemia, Myeloid, Acute; Mutation; Protein Kinase Inhibitors; Pyrroles; Signal Transduction; Staurosporine	2006
Anti-angiogenic and anti-HER therapy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2006, Volume: 60, Issue:6 Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Bevacizumab; Clinical Trials as Topic; ErbB Receptors; Humans; Indoles; Neoplasms; Neovascularization, Pathologic; Protein Kinase Inhibitors; Pyrroles; Quinazolines; Receptors, Vascular Endothelial Growth Factor	2006
[Recent advances in the study of pharmacological activities and solid-phase synthesis of indoles and their analogues]. Yao xue xue bao = Acta pharmaceutica Sinica, 2006, Volume: 41, Issue:8 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; Antineoplastic Agents; Humans; Indoles; Molecular Structure; Pyrroles	2006
Clinical implications for vascular endothelial growth factor in the lung: friend or foe? Respiratory research, 2006, Oct-17, Volume: 7 Topics: Angiogenesis Inhibitors; Angiopoietins; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Bevacizumab; Ephrins; Humans; Hypoxia; Indoles; Lung; Lung Diseases; Pleural Diseases; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Pyrroles; Receptors, Vascular Endothelial Growth Factor; Transcription, Genetic; Vascular Endothelial Growth Factor A	2006
[Clinical importance of angiogenesis and angiogenic factors in oncohematology]. Wiadomosci lekarskie (Warsaw, Poland : 1960), 2007, Volume: 60, Issue:1-2 Topics: Angiogenesis Inducing Agents; Angiogenesis Inhibitors; Angiopoietin-1; Angiopoietin-2; Hematologic Neoplasms; Humans; Indoles; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid, Acute; Multiple Myeloma; Myelodysplastic Syndromes; Neoplasm Metastasis; Neovascularization, Pathologic; Oxindoles; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Propionates; Pyrroles; Receptor, TIE-2; Receptors, Vascular Endothelial Growth Factor; Vascular Endothelial Growth Factors	2007
The effects of antiangiogenic compound SU5416 in a rat model of pulmonary arterial hypertension. Respiration; international review of thoracic diseases, 2011, Volume: 81, Issue:3 Topics: Angiogenesis Inhibitors; Animals; Cell Proliferation; Disease Models, Animal; Endothelial Cells; Hypertension, Pulmonary; Indoles; Pyrroles; Rats; Receptors, Vascular Endothelial Growth Factor	2011
Emerging therapies targeting tumor vasculature in multiple myeloma and other hematologic and solid malignancies. Current cancer drug targets, 2011, Volume: 11, Issue:9 Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal; Benzenesulfonates; Hematologic Neoplasms; Humans; Indoles; Multiple Myeloma; Neovascularization, Pathologic; Niacinamide; Phenylurea Compounds; Phthalazines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyridines; Pyrroles; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Sorafenib; Sunitinib; Thalidomide; Vascular Endothelial Growth Factor A; Wnt Signaling Pathway	2011
Clinical experience with antiangiogenic therapy in leukemia. Current cancer drug targets, 2011, Volume: 11, Issue:9 Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Benzenesulfonates; Bevacizumab; Clinical Trials as Topic; Humans; Indoles; Lenalidomide; Leukemia; Neovascularization, Pathologic; Niacinamide; Phenylurea Compounds; Pyridines; Pyrroles; Quinazolines; Sorafenib; Staurosporine; Sunitinib; Thalidomide; TOR Serine-Threonine Kinases; Vascular Endothelial Growth Factor A	2011
Targeting vascular changes in lesions in multiple sclerosis and experimental autoimmune encephalomyelitis. Central nervous system agents in medicinal chemistry, 2012, Volume: 12, Issue:1 Topics: Angiogenesis Inhibitors; Animals; Drug Delivery Systems; Encephalomyelitis, Autoimmune, Experimental; Humans; Indoles; Multiple Sclerosis; Pyrroles; Thalidomide	2012
Diagnostic and therapeutic implications of the vascular endothelial growth factor family in cancer. Asian Pacific journal of cancer prevention : APJCP, 2015, Volume: 16, Issue:5 Topics: Angiogenesis Inhibitors; Bevacizumab; Humans; Indoles; Neoplasm Metastasis; Neoplasm Staging; Neoplasms; Neovascularization, Pathologic; Prognosis; Protein Kinase Inhibitors; Pyrroles; Receptors, Vascular Endothelial Growth Factor; Vascular Endothelial Growth Factors	2015
Plexiform Arteriopathy in Rodent Models of Pulmonary Arterial Hypertension. The American journal of pathology, 2019, Volume: 189, Issue:6 Topics: Animals; Disease Models, Animal; Disease Progression; Humans; Hypoxia; Indoles; MAP Kinase Signaling System; Mice; Mice, Knockout; Pulmonary Arterial Hypertension; Pulmonary Artery; Pyrroles; Rats	2019
The Role of Regulatory T Cells in Pulmonary Arterial Hypertension. Frontiers in immunology, 2021, Volume: 12 Topics: Animals; Autoimmunity; Endothelium, Vascular; Humans; Indoles; Pulmonary Arterial Hypertension; Pyrroles; Rats; Sex Characteristics; T-Lymphocytes, Regulatory; Vascular System Injuries	2021

Trials

31 trial(s) available for pyrroles and semaxinib

Article	Year
Dose-finding and pharmacokinetic study of cisplatin, gemcitabine, and SU5416 in patients with solid tumors. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2002, Mar-15, Volume: 20, Issue:6 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Deoxycytidine; Drug Administration Schedule; Female; Gemcitabine; Humans; Indoles; Infusions, Intravenous; Male; Middle Aged; Neoplasms; Pyrroles; Thromboembolism; Treatment Outcome	2002
Paradoxical secondary polycythemia in von Hippel-Lindau patients treated with anti-vascular endothelial growth factor receptor therapy. Blood, 2002, May-15, Volume: 99, Issue:10 Topics: Adult; Angiogenesis Inhibitors; Enzyme Inhibitors; Female; Hematocrit; Humans; Indoles; Kinetics; Male; Middle Aged; Polycythemia; Pyrroles; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; von Hippel-Lindau Disease	2002
Results of a Phase I dose-escalating study of the antiangiogenic agent, SU5416, in patients with advanced malignancies. Clinical cancer research : an official journal of the American Association for Cancer Research, 2002, Volume: 8, Issue:9 Topics: Adult; Aged; Angiogenesis Inhibitors; Combined Modality Therapy; Endothelial Growth Factors; Fatigue; Female; Fibroblast Growth Factor 2; Headache; Humans; Indoles; Intercellular Signaling Peptides and Proteins; Lymphokines; Male; Middle Aged; Molecular Structure; Nausea; Neoplasms; Pyrroles; Salvage Therapy; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Vomiting	2002
Analysis of coagulation cascade and endothelial cell activation during inhibition of vascular endothelial growth factor/vascular endothelial growth factor receptor pathway in cancer patients. Arteriosclerosis, thrombosis, and vascular biology, 2002, Sep-01, Volume: 22, Issue:9 Topics: Angiogenesis Inhibitors; Blood Coagulation; Blood Platelets; Carcinoma, Renal Cell; Cell Division; Cell Membrane Permeability; Cell Movement; Drug Administration Schedule; Endothelium, Vascular; Fibrinolysis; Hemostasis; Humans; Indoles; Kidney Neoplasms; Melanoma; Neovascularization, Pathologic; Protein C; Proto-Oncogene Proteins; Pyrroles; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; Sarcoma; Thrombin; Vascular Endothelial Growth Factor Receptor-1	2002
SU5416, a small molecule tyrosine kinase receptor inhibitor, has biologic activity in patients with refractory acute myeloid leukemia or myelodysplastic syndromes. Blood, 2003, Aug-01, Volume: 102, Issue:3 Topics: Acute Disease; Adult; Aged; Antineoplastic Agents; Apoptosis; Bone Marrow Cells; Bone Marrow Examination; Humans; Indoles; Leukemia, Myeloid; Middle Aged; Myelodysplastic Syndromes; Necrosis; Pharmacokinetics; Protein-Tyrosine Kinases; Pyrroles; Remission Induction; Salvage Therapy	2003
Phase II study of SU5416--a small-molecule, vascular endothelial growth factor tyrosine-kinase receptor inhibitor--in patients with refractory myeloproliferative diseases. Cancer, 2003, Apr-15, Volume: 97, Issue:8 Topics: Adult; Aged; Aged, 80 and over; Bone Marrow; Endothelial Growth Factors; Female; Fusion Proteins, bcr-abl; Humans; Indoles; Intercellular Signaling Peptides and Proteins; Lymphokines; Male; Middle Aged; Myeloproliferative Disorders; Protein-Tyrosine Kinases; Pyrroles; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2; Vascular Endothelial Growth Factors	2003
Efficacy and toxicity of the angiogenesis inhibitor SU5416 as a single agent in patients with advanced renal cell carcinoma, melanoma, and soft tissue sarcoma. Clinical cancer research : an official journal of the American Association for Cancer Research, 2003, Volume: 9, Issue:5 Topics: Adult; Aged; Angiogenesis Inhibitors; Carcinoma, Renal Cell; Disease-Free Survival; Enzyme Inhibitors; Female; Humans; Indoles; Kidney Neoplasms; Male; Melanoma; Middle Aged; Neovascularization, Pathologic; Protein-Tyrosine Kinases; Pyrroles; Sarcoma; Skin Neoplasms; Treatment Outcome	2003
Potential role of platelets in endothelial damage observed during treatment with cisplatin, gemcitabine, and the angiogenesis inhibitor SU5416. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, Jun-01, Volume: 21, Issue:11 Topics: Aged; Angiogenesis Inhibitors; Antineoplastic Combined Chemotherapy Protocols; Blood Platelets; Cisplatin; Deoxycytidine; E-Selectin; Endothelial Growth Factors; Endothelium, Vascular; Female; Gemcitabine; Humans; Indoles; Intercellular Signaling Peptides and Proteins; Lymphokines; Male; Middle Aged; Multivariate Analysis; Platelet Count; Pyrroles; Regression Analysis; Thromboembolism; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors	2003
A phase 2 clinical study of SU5416 in patients with refractory acute myeloid leukemia. Blood, 2003, Oct-15, Volume: 102, Issue:8 Topics: Adult; Aged; Angiogenesis Inhibitors; Bone Marrow; Cell Separation; Enzyme Inhibitors; Female; Flow Cytometry; Humans; Indoles; Leukemia, Myeloid, Acute; Male; Membrane Proteins; Microcirculation; Middle Aged; Mutation; Polymerase Chain Reaction; Pyrroles; Recurrence; Remission Induction; Time Factors; Treatment Outcome; Vascular Endothelial Growth Factor A	2003
SU5416 plus interferon alpha in advanced renal cell carcinoma: a phase II California Cancer Consortium Study with biological and imaging correlates of angiogenesis inhibition. Clinical cancer research : an official journal of the American Association for Cancer Research, 2003, Oct-15, Volume: 9, Issue:13 Topics: Adult; Aged; Angiogenesis Inhibitors; Antineoplastic Combined Chemotherapy Protocols; California; Carcinoma, Renal Cell; Cell Line, Tumor; Disease Progression; Disease-Free Survival; Dose-Response Relationship, Drug; Female; Humans; Immunotherapy; Indoles; Interferon alpha-2; Interferon-alpha; Kidney Neoplasms; Male; Middle Aged; Neovascularization, Pathologic; Pyrroles; Recombinant Proteins; Time Factors; Tomography, Emission-Computed; Treatment Outcome; Vascular Endothelial Growth Factor A	2003
Phase II study of SU5416, a small molecule vascular endothelial growth factor tyrosine kinase receptor inhibitor, in patients with refractory multiple myeloma. Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Jan-01, Volume: 10, Issue:1 Pt 1 Topics: Adult; Aged; Angiogenesis Inhibitors; Biomarkers, Tumor; Drug Resistance, Neoplasm; Enzyme Inhibitors; Female; Humans; Indoles; Male; Middle Aged; Multiple Myeloma; Neovascularization, Pathologic; Protein-Tyrosine Kinases; Pyrroles; Remission Induction; Salvage Therapy; Survival Rate; Thalidomide; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2	2004
Antiangiogenic therapy for von Hippel-Lindau disease. JAMA, 2004, Feb-25, Volume: 291, Issue:8 Topics: Adult; Angiogenesis Inhibitors; Brain Neoplasms; Female; Hemangioblastoma; Humans; Indoles; Male; Middle Aged; Pyrroles; Retinal Neoplasms; Spinal Cord Neoplasms; Treatment Outcome; Vascular Endothelial Growth Factor A; von Hippel-Lindau Disease	2004
Effects of SU5416, a small molecule tyrosine kinase receptor inhibitor, on FLT3 expression and phosphorylation in patients with refractory acute myeloid leukemia. Leukemia research, 2004, Volume: 28, Issue:7 Topics: Acute Disease; Adult; Aged; Bone Marrow; Down-Regulation; Female; fms-Like Tyrosine Kinase 3; Humans; Indoles; Leukemia, Myeloid; Male; Membrane Proteins; Middle Aged; Mutation; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Pyrroles; Receptor Protein-Tyrosine Kinases; Stem Cell Factor	2004
A randomized Phase II trial of the antiangiogenic agent SU5416 in hormone-refractory prostate cancer. Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, May-15, Volume: 10, Issue:10 Topics: Aged; Aged, 80 and over; Angiogenesis Inhibitors; Biomarkers, Tumor; Cell Line, Tumor; Dexamethasone; Dose-Response Relationship, Drug; Fibroblast Growth Factors; Humans; Indoles; Male; Middle Aged; Prognosis; Prostate-Specific Antigen; Prostatic Neoplasms; Pyrroles; Time Factors; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2	2004
Phase II study of the Flk-1 tyrosine kinase inhibitor SU5416 in advanced melanoma. Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Jun-15, Volume: 10, Issue:12 Pt 1 Topics: Adult; Aged; Angiogenesis Inhibitors; Female; Glucose; Humans; Indoles; Lymphocytes; Magnetic Resonance Imaging; Male; Melanoma; Middle Aged; Neoplasm Metastasis; Neovascularization, Pathologic; Protein Kinase Inhibitors; Pyrroles; Time Factors; Treatment Outcome; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2	2004
Semiquantitative analysis of dynamic contrast enhanced MRI in cancer patients: Variability and changes in tumor tissue over time. Journal of magnetic resonance imaging : JMRI, 2004, Volume: 20, Issue:1 Topics: Angiogenesis Inhibitors; Colonic Neoplasms; Contrast Media; Gadolinium DTPA; Humans; Indoles; Liver; Liver Neoplasms; Magnetic Resonance Imaging; Melanoma; Mesothelioma; Muscle, Skeletal; Protein-Tyrosine Kinases; Pyrroles	2004
Phase II study of the antiangiogenic agent SU5416 in patients with advanced soft tissue sarcomas. Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Sep-01, Volume: 10, Issue:17 Topics: Adult; Aged; Angiogenesis Inhibitors; Disease-Free Survival; Female; Humans; Indoles; Infusions, Intravenous; Male; Maximum Tolerated Dose; Middle Aged; Proto-Oncogene Proteins c-kit; Pyrroles; Receptors, Vascular Endothelial Growth Factor; Safety; Sarcoma; Survival Rate; Vascular Endothelial Growth Factor A	2004
A phase IB clinical and pharmacokinetic study of the angiogenesis inhibitor SU5416 and paclitaxel in recurrent or metastatic carcinoma of the head and neck. Cancer chemotherapy and pharmacology, 2005, Volume: 55, Issue:3 Topics: Adult; Aged; Angiogenesis Inhibitors; Antineoplastic Combined Chemotherapy Protocols; Female; Head and Neck Neoplasms; Humans; Indoles; Maximum Tolerated Dose; Middle Aged; Neoplasm Recurrence, Local; Paclitaxel; Pyrroles	2005
Enhancing the therapeutic responsiveness of photodynamic therapy with the antiangiogenic agents SU5416 and SU6668 in murine nasopharyngeal carcinoma models. Cancer chemotherapy and pharmacology, 2005, Volume: 56, Issue:6 Topics: Adenocarcinoma; Angiogenesis Inhibitors; Animals; Anthracenes; Antineoplastic Agents; Chemotherapy, Adjuvant; Drug Screening Assays, Antitumor; Gene Expression; Indoles; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Nasopharyngeal Neoplasms; Neoplasm Transplantation; Neoplasms, Experimental; Oxindoles; Perylene; Photochemotherapy; Propionates; Protein-Tyrosine Kinases; Proteins; Pyrroles; Survival Rate	2005
A Phase I study of the angiogenesis inhibitor SU5416 (semaxanib) in solid tumours, incorporating dynamic contrast MR pharmacodynamic end points. British journal of cancer, 2005, Oct-17, Volume: 93, Issue:8 Topics: Adolescent; Adult; Aged; Angiogenesis Inhibitors; Drug Administration Schedule; Endpoint Determination; Female; Humans; Indoles; Infusions, Intravenous; Magnetic Resonance Imaging; Male; Maximum Tolerated Dose; Middle Aged; Neoplasms; Pyrroles	2005
A phase I study with oral SU5416 in patients with advanced solid tumors: a drug inducing its clearance. Investigational new drugs, 2006, Volume: 24, Issue:4 Topics: Administration, Oral; Adult; Drug Administration Schedule; Female; Humans; Indoles; Infusions, Intravenous; Middle Aged; Neoplasm Staging; Neoplasms; Protein Kinase Inhibitors; Pyrroles	2006
Novel Phase I dose de-escalation design trial to determine the biological modulatory dose of the antiangiogenic agent SU5416. Clinical cancer research : an official journal of the American Association for Cancer Research, 2005, Nov-01, Volume: 11, Issue:21 Topics: Adult; Aged; Angiogenesis Inhibitors; Biopsy; Bone Density; Cell Adhesion; Cell Adhesion Molecules; Contrast Media; E-Selectin; Female; Fibroblast Growth Factor 2; Humans; Indoles; Intercellular Adhesion Molecule-1; Kinetics; Magnetic Resonance Imaging; Male; Maximum Tolerated Dose; Microcirculation; Middle Aged; Neoplasm Transplantation; Perfusion; Protein Kinase Inhibitors; Pyrroles; Time Factors; Vascular Cell Adhesion Molecule-1; Vascular Endothelial Growth Factor A	2005
A Phase I study of escalating doses of the tyrosine kinase inhibitor semaxanib (SU5416) in combination with irinotecan in patients with advanced colorectal carcinoma. Japanese journal of clinical oncology, 2006, Volume: 36, Issue:2 Topics: Aged; Angiogenesis Inhibitors; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carcinoma; Colorectal Neoplasms; Dose-Response Relationship, Drug; Female; Humans; Indoles; Irinotecan; Male; Maximum Tolerated Dose; Middle Aged; Protein Kinase Inhibitors; Pyrroles; Treatment Outcome	2006
Phase I/pilot study of SU5416 (semaxinib) in combination with irinotecan/bolus 5-FU/LV (IFL) in patients with metastatic colorectal cancer. American journal of clinical oncology, 2006, Volume: 29, Issue:2 Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Drug Administration Schedule; Female; Fluorouracil; Humans; Indoles; Infusions, Intravenous; Injections, Intravenous; Irinotecan; Leucovorin; Male; Middle Aged; Neoplasm Metastasis; Pyrroles; Vascular Endothelial Growth Factor Receptor-2	2006
A phase II, pharmacokinetic, and biologic study of semaxanib and thalidomide in patients with metastatic melanoma. Cancer chemotherapy and pharmacology, 2007, Volume: 59, Issue:2 Topics: Adult; Aged; Angiogenesis Inhibitors; Area Under Curve; Asthenia; Dose-Response Relationship, Drug; Edema; Female; Half-Life; Headache; Humans; Indoles; Male; Melanoma; Middle Aged; Neoplasm Metastasis; Peripheral Nervous System Diseases; Protein Kinase Inhibitors; Pyrroles; Thalidomide; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A; Venous Thrombosis	2007
A Phase II study of SU5416 in patients with advanced or recurrent head and neck cancers. Investigational new drugs, 2007, Volume: 25, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Angiogenesis Inhibitors; Blood Pressure; Female; Head and Neck Neoplasms; Heart Rate; Humans; Indoles; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasms, Squamous Cell; Pyrroles; Regional Blood Flow; Ultrasonography; Vascular Endothelial Growth Factor A	2007
Downregulation of VEGF-A, STAT5 and AKT in acute myeloid leukemia blasts of patients treated with SU5416. Leukemia & lymphoma, 2006, Volume: 47, Issue:12 Topics: Angiogenesis Inhibitors; Cell Line, Tumor; Cell Separation; Disease Progression; DNA Primers; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; Indoles; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrroles; Signal Transduction; STAT5 Transcription Factor; Treatment Outcome; Vascular Endothelial Growth Factor A	2006
Inflammatory breast cancer as a model disease to study tumor angiogenesis: results of a phase IB trial of combination SU5416 and doxorubicin. Clinical cancer research : an official journal of the American Association for Cancer Research, 2007, Oct-01, Volume: 13, Issue:19 Topics: Adult; Aged; Angiogenesis Inhibitors; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Disease-Free Survival; Doxorubicin; Female; Humans; Indoles; Inflammation; Male; Maximum Tolerated Dose; Middle Aged; Neovascularization, Pathologic; Pyrroles; Treatment Outcome	2007
Phase I study of SU5416, a small molecule inhibitor of the vascular endothelial growth factor receptor (VEGFR) in refractory pediatric central nervous system tumors. Pediatric blood & cancer, 2009, Volume: 52, Issue:2 Topics: Adolescent; Angiogenesis Inhibitors; Anticonvulsants; Arthralgia; Central Nervous System Neoplasms; Child; Drug Interactions; Drug Therapy, Combination; Female; Hallucinations; Humans; Indoles; Liver; Male; Maximum Tolerated Dose; Protein Kinase Inhibitors; Pyrroles; Receptors, Vascular Endothelial Growth Factor; Treatment Outcome; Young Adult	2009
Endothelial cell-specific chemotaxis receptor (ECSCR) enhances vascular endothelial growth factor (VEGF) receptor-2/kinase insert domain receptor (KDR) activation and promotes proteolysis of internalized KDR. The Journal of biological chemistry, 2013, Apr-12, Volume: 288, Issue:15 Topics: Animals; Animals, Genetically Modified; Apoptosis Regulatory Proteins; Cell Line; Endosomes; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Female; Hemangioma; Human Umbilical Vein Endothelial Cells; Humans; Indoles; Male; Membrane Proteins; Placenta; Pregnancy; Protein Kinase Inhibitors; Proteolysis; Proto-Oncogene Proteins c-akt; Pyrroles; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2; Zebrafish	2013
A phase I dose escalation and pharmacodynamic study of SU5416 (semaxanib) combined with weekly cisplatin and irinotecan in patients with advanced solid tumors. Onkologie, 2013, Volume: 36, Issue:11 Topics: Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemotherapy-Induced Febrile Neutropenia; Cisplatin; Dose-Response Relationship, Drug; Female; Humans; Indoles; Irinotecan; Male; Middle Aged; Nausea; Neoplasms; Pyrroles; Thrombocytopenia; Treatment Outcome	2013

Other Studies

332 other study(ies) available for pyrroles and semaxinib

Article	Year
SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types. Cancer research, 1999, Jan-01, Volume: 59, Issue:1 Topics: 3T3 Cells; Animals; Catalysis; Cell Division; Endothelium, Vascular; Enzyme Inhibitors; Glioma; Humans; Indoles; Mice; Neoplasms, Experimental; Neovascularization, Pathologic; Protein-Tyrosine Kinases; Pyrroles; Rats; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Mitogen; Receptors, Vascular Endothelial Growth Factor; Tumor Cells, Cultured	1999
Antiangiogenic therapy targeting the tyrosine kinase receptor for vascular endothelial growth factor receptor inhibits the growth of colon cancer liver metastasis and induces tumor and endothelial cell apoptosis. Cancer research, 1999, Nov-01, Volume: 59, Issue:21 Topics: Animals; Apoptosis; Colonic Neoplasms; Endothelium; Fluorescent Antibody Technique; In Situ Nick-End Labeling; Indoles; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Neovascularization, Pathologic; Pyrroles; Random Allocation; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; Tumor Cells, Cultured	1999
Inhibition of angiogenesis by blocking activation of the vascular endothelial growth factor receptor 2 leads to decreased growth of neurogenic sarcomas. Cancer research, 1999, Nov-01, Volume: 59, Issue:21 Topics: Angiogenesis Inhibitors; Animals; Chemotherapy, Adjuvant; Dose-Response Relationship, Drug; Endothelial Growth Factors; Enzyme Inhibitors; Indoles; Lymphokines; Male; Mice; Mice, Inbred NOD; Mice, SCID; Neoplasm Metastasis; Neoplasm Recurrence, Local; Neoplasm Transplantation; Neovascularization, Pathologic; Neurofibromatosis 1; Neurons; Pyrroles; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; Sarcoma; Time Factors; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors	1999
Vascular endothelial growth factor in human colon cancer: biology and therapeutic implications. The oncologist, 2000, Volume: 5 Suppl 1 Topics: Angiogenesis Inhibitors; Animals; Apoptosis; Cell Division; Colonic Neoplasms; Disease Models, Animal; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Inhibitors; Humans; Indoles; Liver Neoplasms; Lymphokines; Mice; Neoplasm Metastasis; Neovascularization, Pathologic; Prognosis; Protein Isoforms; Protein-Tyrosine Kinases; Pyrroles; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Mitogen; Receptors, Vascular Endothelial Growth Factor; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors	2000
Measuring VEGF-Flk-1 activity and consequences of VEGF-Flk-1 targeting in vivo using intravital microscopy: clinical applications. The oncologist, 2000, Volume: 5 Suppl 1 Topics: Analysis of Variance; Angiogenesis Inhibitors; Animals; Disease Models, Animal; Endothelial Growth Factors; Enzyme Inhibitors; Glioblastoma; Indoles; Lymphokines; Male; Mice; Mice, Nude; Microcirculation; Microscopy, Fluorescence; Microscopy, Video; Neoplasm Transplantation; Neovascularization, Pathologic; Protein Isoforms; Protein-Tyrosine Kinases; Pyrroles; Rats; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Mitogen; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Skin Neoplasms; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors	2000
Targeting vascular endothelial growth factor blockade: ascites and pleural effusion formation. The oncologist, 2000, Volume: 5 Suppl 1 Topics: Angiogenesis Inhibitors; Antibodies; Ascites; Cell Division; Cells, Cultured; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Inhibitors; Humans; Indoles; Lymphokines; Pleural Effusion; Pleural Effusion, Malignant; Protein Isoforms; Protein-Tyrosine Kinases; Pyrroles; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Mitogen; Receptors, Vascular Endothelial Growth Factor; Recurrence; Umbilical Veins; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors	2000
Clinical strategy for the development of angiogenesis inhibitors. The oncologist, 2000, Volume: 5 Suppl 1 Topics: Angiogenesis Inhibitors; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Carcinoma, Non-Small-Cell Lung; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Colorectal Neoplasms; Decision Making; Disease Progression; Drug Evaluation; Drug Resistance, Neoplasm; Drugs, Investigational; Endothelial Growth Factors; Enzyme Inhibitors; Humans; Indoles; Lung Neoplasms; Lymphokines; Protein Isoforms; Protein-Tyrosine Kinases; Pyrroles; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors	2000
Clinical trials, referral resource. Treatment of advanced or recurrent squamous cell carcinoma of the head and neck. Oncology (Williston Park, N.Y.), 2000, Volume: 14, Issue:4 Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Carcinoma, Squamous Cell; Cetuximab; Clinical Trials as Topic; Combined Modality Therapy; Head and Neck Neoplasms; Humans; Indoles; Platinum Compounds; Pyrroles; Recurrence	2000
Tyrosine kinase inhibitor research presses on despite halted clinical trial. Journal of the National Cancer Institute, 2000, Jun-21, Volume: 92, Issue:12 Topics: Clinical Trials, Phase I as Topic; Clinical Trials, Phase III as Topic; Drugs, Investigational; Enzyme Inhibitors; ErbB Receptors; Genes, src; Humans; Indoles; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Pyrroles; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; Signal Transduction	2000
Targeting angiogenesis inhibits tumor infiltration and expression of the pro-invasive protein SPARC. International journal of cancer, 2000, Jul-15, Volume: 87, Issue:2 Topics: Angiogenesis Inhibitors; Animals; Biomarkers, Tumor; Cell Division; Cell Movement; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glioma; Immunohistochemistry; Indoles; Male; Mice; Mice, Nude; Microscopy, Fluorescence; Microscopy, Video; Neoplasm Invasiveness; Neoplasm Transplantation; Neovascularization, Pathologic; Osteonectin; Pyrroles; Rats; Solvents; Time Factors; Tumor Cells, Cultured	2000
Researchers describe findings for targeted cancer therapies. JAMA, 2000, Jul-19, Volume: 284, Issue:3 Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Cell Division; Cetuximab; Clinical Trials as Topic; Endothelial Growth Factors; ErbB Receptors; Humans; Indoles; Lymphokines; Neoplasms; Pyrroles; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors	2000
KS trial begins. AIDS patient care and STDs, 2000, Volume: 14, Issue:6 Topics: Acquired Immunodeficiency Syndrome; Angiogenesis Inhibitors; Clinical Trials, Phase II as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Indoles; Male; Multicenter Studies as Topic; Patient Selection; Pyrroles; Sarcoma, Kaposi; United States	2000
Inhibition of tumor growth, angiogenesis, and microcirculation by the novel Flk-1 inhibitor SU5416 as assessed by intravital multi-fluorescence videomicroscopy. Neoplasia (New York, N.Y.), 1999, Volume: 1, Issue:1 Topics: Animals; Antineoplastic Agents; Enzyme Inhibitors; Glioblastoma; Indoles; Male; Mice; Mice, Nude; Microcirculation; Neovascularization, Pathologic; Pyrroles; Rats; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor	1999
Inhibition of angiogenesis decreases alveolarization in the developing rat lung. American journal of physiology. Lung cellular and molecular physiology, 2000, Volume: 279, Issue:3 Topics: Angiogenesis Inhibitors; Animals; Animals, Newborn; Barium Sulfate; Body Weight; Cyclohexanes; Fatty Acids, Unsaturated; Gelatin; Heart; Indoles; Injections, Intra-Arterial; Lung; Neovascularization, Physiologic; Organ Size; Pulmonary Alveoli; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; Sesquiterpenes; Thalidomide	2000
Clinical trials referral resource. Current clinical trials administering the antiangiogenesis agent SU5416. Oncology (Williston Park, N.Y.), 2000, Volume: 14, Issue:9 Topics: Angiogenesis Inhibitors; Clinical Trials as Topic; Indoles; Pyrroles	2000
Biotransformation of the anti-angiogenic compound SU5416. Drug metabolism and disposition: the biological fate of chemicals, 2000, Volume: 28, Issue:12 Topics: Angiogenesis Inhibitors; Animals; Biotransformation; Chromatography, High Pressure Liquid; Dogs; Glucuronides; Humans; In Vitro Techniques; Indoles; Macaca fascicularis; Mice; Microsomes, Liver; Pyrroles; Rats; Rats, Sprague-Dawley; Species Specificity; Spectrophotometry, Ultraviolet	2000
Inhibition of VEGF receptors causes lung cell apoptosis and emphysema. The Journal of clinical investigation, 2000, Volume: 106, Issue:11 Topics: Angiography; Animals; Apoptosis; Aspartic Acid; Caspase 3; Caspase Inhibitors; Caspases; Cell Adhesion; Cells, Cultured; Collagen; DNA Fragmentation; Dose-Response Relationship, Drug; Drug Combinations; Enzyme Inhibitors; Epithelial Cells; Immunohistochemistry; In Situ Nick-End Labeling; Indoles; Laminin; Lung; Male; Proliferating Cell Nuclear Antigen; Protease Inhibitors; Proteoglycans; Pulmonary Emphysema; Pyrroles; Rats; Rats, Sprague-Dawley; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor	2000
The angiogenesis inhibitor SU5416 has long-lasting effects on vascular endothelial growth factor receptor phosphorylation and function. Clinical cancer research : an official journal of the American Association for Cancer Research, 2000, Volume: 6, Issue:12 Topics: 3T3 Cells; Angiogenesis Inhibitors; Animals; Cell Division; Cell Membrane; Cell Separation; Cells, Cultured; Culture Media, Serum-Free; Dose-Response Relationship, Drug; Endothelium, Vascular; Epitopes; Female; Flow Cytometry; Humans; Indoles; Kinetics; Mice; Mice, Nude; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neoplasm Transplantation; Neovascularization, Pathologic; Phosphorylation; Protein Binding; Protein-Tyrosine Kinases; Pyrroles; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Time Factors; Tumor Cells, Cultured; Umbilical Cord	2000
Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death-dependent pulmonary endothelial cell proliferation and severe pulmonary hypertension. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2001, Volume: 15, Issue:2 Topics: Angiogenesis Inhibitors; Animals; Apoptosis; Blood Pressure; Caspase 3; Caspases; Cell Death; Cell Division; Endothelium, Vascular; Heart Ventricles; Hypertension, Pulmonary; Hypoxia; Indoles; Male; Muscle, Smooth, Vascular; Myocardium; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor	2001
The antiangiogenic protein kinase inhibitors SU5416 and SU6668 inhibit the SCF receptor (c-kit) in a human myeloid leukemia cell line and in acute myeloid leukemia blasts. Blood, 2001, Mar-01, Volume: 97, Issue:5 Topics: Angiogenesis Inhibitors; Apoptosis; Caspase 3; Caspases; Cell Division; Dose-Response Relationship, Drug; Humans; Indoles; Leukemia, Myeloid; Mitogen-Activated Protein Kinases; Oxindoles; Phosphorylation; Propionates; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-kit; Pyrroles; Stem Cell Factor; Tumor Cells, Cultured	2001
Inhibition of vascular endothelial growth factor receptor signaling leads to reversal of tumor resistance to radiotherapy. Cancer research, 2001, Mar-15, Volume: 61, Issue:6 Topics: Angiogenesis Inhibitors; Animals; Cell Survival; Dose-Response Relationship, Radiation; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Inhibitors; Glioblastoma; Indoles; Lymphokines; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Neovascularization, Pathologic; Pyrroles; Radiation Tolerance; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors	2001
Indolinone tyrosine kinase inhibitors block Kit activation and growth of small cell lung cancer cells. Cancer research, 2001, May-01, Volume: 61, Issue:9 Topics: Animals; Carcinoma, Small Cell; Cell Division; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Growth Inhibitors; Humans; Indoles; Lung Neoplasms; Models, Molecular; Oxindoles; Phosphorylation; Propionates; Proto-Oncogene Proteins c-kit; Pyrroles; Receptor Protein-Tyrosine Kinases; Receptors, Platelet-Derived Growth Factor; Stem Cell Factor; Structure-Activity Relationship; Tumor Cells, Cultured	2001
Nonvascular role for VEGF: VEGFR-1, 2 activity is critical for neural retinal development. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2001, Volume: 15, Issue:7 Topics: Angiogenesis Inhibitors; Animals; Humans; Immunohistochemistry; In Situ Hybridization; Indoles; Mice; Mitogen-Activated Protein Kinases; Models, Biological; Proto-Oncogene Proteins; Pyrroles; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; Retina; Retinal Neovascularization; Retinal Vessels; RNA, Messenger; Vascular Endothelial Growth Factor Receptor-1	2001
Simultaneous determination of SU5416 and its phase I and phase II metabolites in rat and dog plasma by LC/MS/MS. Journal of pharmaceutical and biomedical analysis, 2001, Volume: 25, Issue:5-6 Topics: Angiogenesis Inhibitors; Animals; Chromatography, Liquid; Dogs; Indoles; Mass Spectrometry; Pyrroles; Rats; Reproducibility of Results; Sensitivity and Specificity	2001
Stable remission after administration of the receptor tyrosine kinase inhibitor SU5416 in a patient with refractory acute myeloid leukemia. Blood, 2001, Jul-01, Volume: 98, Issue:1 Topics: Acute Disease; Angiogenesis Inhibitors; Antineoplastic Agents; Bone Marrow Cells; Endothelium, Vascular; Female; Humans; Immunohistochemistry; Indoles; Leukemia, Myeloid; Middle Aged; Protein-Tyrosine Kinases; Pyrroles; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; Remission Induction	2001
Wound-induced angiogenesis and its pharmacologic inhibition in a murine model. Surgery, 2001, Volume: 130, Issue:3 Topics: Angiogenesis Inhibitors; Animals; Female; Indoles; Mice; Mice, Inbred BALB C; Microcirculation; Neovascularization, Physiologic; Pyrroles; Skin Window Technique; Wound Healing	2001
Sequential tumor biopsies in early phase clinical trials of anticancer agents for pharmacodynamic evaluation. Clinical cancer research : an official journal of the American Association for Cancer Research, 2001, Volume: 7, Issue:10 Topics: Animals; Antineoplastic Agents; Biopsy; Carmustine; Cisplatin; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Doxorubicin; Fenretinide; Guanine; Humans; Indoles; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase; Paclitaxel; Pyrroles; Tomography, X-Ray Computed; Treatment Outcome; Xenograft Model Antitumor Assays	2001
Magnetic resonance imaging of ethyl-nitrosourea-induced rat gliomas: a model for experimental therapeutics of low-grade gliomas. Journal of neuro-oncology, 2001, Volume: 53, Issue:3 Topics: Angiogenesis Inhibitors; Animals; Brain Neoplasms; Carcinogens; Diet; Disease Models, Animal; Diterpenes; Ethylnitrosourea; Glioma; Indoles; Magnetic Resonance Imaging; Neoplasms, Multiple Primary; Neoplasms, Second Primary; Pyrroles; Rats; Rats, Inbred F344; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; Retinyl Esters; Survival Analysis; Time Factors; Vitamin A	2001
Flk-1 specific kinase inhibitor (SU5416) inhibited the growth of GS-9L glioma in rat brain and prolonged the survival. The Kobe journal of medical sciences, 2001, Volume: 47, Issue:4 Topics: Animals; Apoptosis; Brain; Brain Neoplasms; Enzyme Inhibitors; Glioma; Indoles; Male; Microcirculation; Pyrroles; Rats; Rats, Inbred F344; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; Survival Rate	2001
Pharmacokinetics and interspecies scaling of a novel VEGF receptor inhibitor, SU5416. The Journal of pharmacy and pharmacology, 2001, Volume: 53, Issue:12 Topics: Angiogenesis Inhibitors; Animals; Dogs; Female; Humans; Indoles; Male; Metabolic Clearance Rate; Mice; Pyrroles; Rats; Rats, Sprague-Dawley; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; Species Specificity	2001
Unexpected serious toxicity with chemotherapy and antiangiogenic combinations: time to take stock! Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2002, Mar-15, Volume: 20, Issue:6 Topics: Angiogenesis Inhibitors; Antineoplastic Agents; Cisplatin; Deoxycytidine; Drug Combinations; Gemcitabine; Humans; Indoles; Pyrroles	2002
Operative technique for safe pulmonary lobectomy in Sprague-Dawley rats. Contemporary topics in laboratory animal science, 2002, Volume: 41, Issue:2 Topics: Anesthesia, Inhalation; Angiogenesis Inhibitors; Animals; Indoles; Lung; Male; Models, Animal; Pneumonectomy; Postoperative Complications; Pyrroles; Rats; Rats, Sprague-Dawley; Surgery, Veterinary; Thoracotomy; Wound Healing	2002
Inhibition of vascular endothelial growth factor-associated tyrosine kinase activity with SU5416 blocks sprouting in the microvascular endothelial cell spheroid model of angiogenesis. Microvascular research, 2002, Volume: 63, Issue:3 Topics: Angiogenesis Inhibitors; Animals; Cell Differentiation; Cell Division; Cells, Cultured; Collagen; Dose-Response Relationship, Drug; Drug Combinations; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Inhibitors; Extracellular Matrix Proteins; Fibroblast Growth Factor 2; Indoles; Laminin; Lymphokines; Mice; Myosin Heavy Chains; Neovascularization, Pathologic; Nonmuscle Myosin Type IIB; Platelet Endothelial Cell Adhesion Molecule-1; Protein-Tyrosine Kinases; Proteoglycans; Pyrroles; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; Umbilical Cord; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factors	2002
CHS 828 inhibits neuroblastoma growth in mice alone and in combination with antiangiogenic drugs. Pediatric research, 2002, Volume: 51, Issue:5 Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Division; Cyanides; Cyclohexanes; Guanidines; Humans; Indoles; Male; Mice; Mice, Nude; Neovascularization, Pathologic; Neuroblastoma; O-(Chloroacetylcarbamoyl)fumagillol; Pyrroles; Remission Induction; Sesquiterpenes; Tumor Cells, Cultured; Xenograft Model Antitumor Assays	2002
Vascular endothelial growth factor-mediated angiogenesis inhibition and postoperative wound healing in rats. The Journal of surgical research, 2002, Jun-01, Volume: 105, Issue:1 Topics: Angiogenesis Inhibitors; Animals; Endothelial Growth Factors; Endothelium; Indoles; Lung Neoplasms; Lymphokines; Male; Models, Animal; Neovascularization, Physiologic; Pneumonectomy; Pyrroles; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Wound Healing	2002
Orthogonal polarisation spectral imaging as a new tool for the assessment of antivascular tumour treatment in vivo: a validation study. British journal of cancer, 2002, May-20, Volume: 86, Issue:10 Topics: Angiogenesis Inhibitors; Animals; Blood Flow Velocity; Capillaries; Cricetinae; Erythrocytes; Hemoglobins; Image Processing, Computer-Assisted; Indoles; Male; Melanoma, Experimental; Mesocricetus; Microcirculation; Microscopy, Fluorescence; Microscopy, Polarization; Pyrroles; Skin Window Technique	2002
Pharmacia's SU5416 not effective. Expert review of anticancer therapy, 2002, Volume: 2, Issue:1 Topics: Angiogenesis Inhibitors; Clinical Trials, Phase III as Topic; Colorectal Neoplasms; Humans; Indoles; Protein-Tyrosine Kinases; Pyrroles; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor	2002
Treatment of newborn rats with a VEGF receptor inhibitor causes pulmonary hypertension and abnormal lung structure. American journal of physiology. Lung cellular and molecular physiology, 2002, Volume: 283, Issue:3 Topics: Angiography; Animals; Animals, Newborn; Birth Weight; Chronic Disease; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Indoles; Lung; Pulmonary Alveoli; Pulmonary Artery; Pulmonary Circulation; Pyrroles; Rats; Rats, Sprague-Dawley; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; Stress, Physiological	2002
Rapid and durable recovery of visual function in a patient with von hippel-lindau syndrome after systemic therapy with vascular endothelial growth factor receptor inhibitor su5416. Ophthalmology, 2002, Volume: 109, Issue:9 Topics: Angiogenesis Inhibitors; Contrast Sensitivity; Female; Fluorescein Angiography; Hemangioblastoma; Humans; Indoles; Magnetic Resonance Imaging; Middle Aged; Optic Disk; Optic Nerve Neoplasms; Pyrroles; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; Recovery of Function; Visual Acuity; Visual Fields; von Hippel-Lindau Disease	2002
A novel dihydroxanthenone, AGI-B4 with inhibition of VEGF-induced endothelial cell growth. The Journal of antibiotics, 2002, Volume: 55, Issue:7 Topics: Angiogenesis Inhibitors; Aspergillus; Cell Division; Cells, Cultured; Crystallography, X-Ray; Drug Evaluation, Preclinical; Endothelial Growth Factors; Endothelium, Vascular; Fermentation; Fibroblast Growth Factor 2; Humans; Indoles; Inhibitory Concentration 50; Lymphokines; Magnetic Resonance Spectroscopy; Molecular Structure; Pyrroles; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Xanthenes	2002
SU5416 and SU5614 inhibit kinase activity of wild-type and mutant FLT3 receptor tyrosine kinase. Blood, 2002, Oct-15, Volume: 100, Issue:8 Topics: Amino Acid Sequence; Apoptosis; Base Sequence; Cell Division; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Exons; fms-Like Tyrosine Kinase 3; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Indoles; Molecular Sequence Data; Mutagenesis, Site-Directed; Polymerase Chain Reaction; Proto-Oncogene Proteins; Pyrroles; Receptor Protein-Tyrosine Kinases; Receptors, Cell Surface; Recombinant Proteins; Tumor Cells, Cultured	2002
Vascular endothelial growth factor receptor-2 activation induces vascular permeability in hyperstimulated rats, and this effect is prevented by receptor blockade. Endocrinology, 2002, Volume: 143, Issue:11 Topics: Animals; Capillary Permeability; Chorionic Gonadotropin; Corpus Luteum; Endothelial Growth Factors; Female; Gene Expression; Gonadotropins, Equine; Granulosa Cells; Immunohistochemistry; Indoles; Intercellular Signaling Peptides and Proteins; Kinetics; Lymphokines; Mesentery; Ovarian Hyperstimulation Syndrome; Ovariectomy; Ovary; Ovulation Induction; Pyrroles; Rats; Rats, Wistar; RNA, Messenger; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2; Vascular Endothelial Growth Factors; Zona Pellucida	2002
Synthetic lethality: killing cancer with cancer. Journal of the National Cancer Institute, 2002, Nov-20, Volume: 94, Issue:22 Topics: Animals; Antineoplastic Agents; Benzamides; Benzoquinones; Cell Cycle Proteins; DNA-Binding Proteins; E2F Transcription Factors; Gefitinib; Genes, Tumor Suppressor; HSP90 Heat-Shock Proteins; Humans; Imatinib Mesylate; Indoles; Lactams, Macrocyclic; Mutation; Neoplasms; Phosphoric Monoester Hydrolases; Piperazines; PTEN Phosphohydrolase; Pyrimidines; Pyrroles; Quinazolines; Rifabutin; Signal Transduction; Sirolimus; Transcription Factors; Tumor Suppressor Proteins	2002
Colorectal cancer: targeting metastasis and angiogenesis. Clinical colorectal cancer, 2002, Volume: 1, Issue:4 Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal; Colorectal Neoplasms; Disease Progression; Extracellular Matrix; Humans; Indoles; Matrix Metalloproteinases; Neoplasm Metastasis; Neovascularization, Pathologic; Pyrroles	2002
Antiangiogenic effect by SU5416 is partly attributable to inhibition of Flt-1 receptor signaling. Molecular cancer therapeutics, 2002, Volume: 1, Issue:5 Topics: 3T3 Cells; Angiogenesis Inhibitors; Animals; Cell Movement; Cells, Cultured; Chemotaxis; Collagen; DNA, Complementary; Dose-Response Relationship, Drug; Drug Combinations; Endothelium, Vascular; Extracellular Matrix Proteins; Humans; Immunoblotting; Indoles; Laminin; Male; Mice; Monocytes; Myosin Heavy Chains; Neovascularization, Pathologic; Nonmuscle Myosin Type IIB; Phosphorylation; Placenta Growth Factor; Pregnancy Proteins; Protein-Tyrosine Kinases; Proteoglycans; Pyrroles; Transfection; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2	2002
Blockade of in vivo VEGF-KDR/flk-1 signaling does not affect revascularization of freely transplanted pancreatic islets. Transplantation, 2003, Jan-27, Volume: 75, Issue:2 Topics: Animals; Cricetinae; Endothelial Growth Factors; Indoles; Intercellular Signaling Peptides and Proteins; Islets of Langerhans; Islets of Langerhans Transplantation; Lymphokines; Mesocricetus; Microcirculation; Pyrroles; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2; Vascular Endothelial Growth Factors	2003
Comparative study of isoflavone, quinoxaline and oxindole families of anti-angiogenic agents. Angiogenesis, 2002, Volume: 5, Issue:1-2 Topics: Angiogenesis Inhibitors; Endothelium, Vascular; Humans; Indoles; Isoflavones; Neoplasms; Neovascularization, Pathologic; Oxindoles; Propionates; Pyrroles; Quinoxalines	2002
Oxidative stress and apoptosis interact and cause emphysema due to vascular endothelial growth factor receptor blockade. American journal of respiratory cell and molecular biology, 2003, Volume: 29, Issue:1 Topics: Angiogenesis Inhibitors; Animals; Apoptosis; Aspartic Acid; Biomarkers; Caspase Inhibitors; Cysteine Proteinase Inhibitors; Indoles; Lung; Male; Molecular Mimicry; Oxidative Stress; Pulmonary Alveoli; Pulmonary Emphysema; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Vascular Endothelial Growth Factor; Superoxide Dismutase	2003
Interleukin-2 and cancer: critical analysis of results, problems and expectations. Medical hypotheses, 2003, Volume: 60, Issue:2 Topics: Cytokines; Humans; Immunotherapy; Indoles; Interleukin-2; Neoplasm Metastasis; Neoplasms; Neovascularization, Pathologic; Oxindoles; Propionates; Protein-Tyrosine Kinases; Pyrroles; Receptors, Interleukin-2	2003
[Perspectives on the oncologist pharmacopoeia]. Bulletin du cancer, 2003, Volume: 90, Issue:1 Topics: Angiogenesis Inhibitors; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Boronic Acids; Bortezomib; Dioxoles; Indoles; Isoquinolines; Neoplasms; Organoplatinum Compounds; Protease Inhibitors; Pyrazines; Pyrroles; Quinazolines; Sesquiterpenes; Tetrahydroisoquinolines; Trabectedin	2003
Effect of angiogenesis inhibitors on oestrogen-mediated endometrial endothelial cell proliferation in the ovariectomized mouse. Reproduction (Cambridge, England), 2003, Volume: 125, Issue:3 Topics: Angiogenesis Inhibitors; Animals; Cell Division; Endometrium; Endothelial Growth Factors; Endothelium, Vascular; Estrogens; Female; Fibroblast Growth Factors; Immune Sera; Indoles; Intercellular Signaling Peptides and Proteins; Lymphokines; Mice; Mice, Inbred Strains; Ovariectomy; Platelet-Derived Growth Factor; Progesterone; Pyrroles; Receptor Protein-Tyrosine Kinases; Receptor, Fibroblast Growth Factor, Type 1; Receptors, Fibroblast Growth Factor; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2; Vascular Endothelial Growth Factors	2003
Pharmacodynamic-mediated effects of the angiogenesis inhibitor SU5416 on the tumor disposition of temozolomide in subcutaneous and intracerebral glioma xenograft models. The Journal of pharmacology and experimental therapeutics, 2003, Volume: 305, Issue:3 Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents, Alkylating; Dacarbazine; Disease Models, Animal; Drug Interactions; Glioma; Indoles; Neoplasm Transplantation; Neoplasms, Experimental; Pyrroles; Rats; Rats, Nude; Receptors, Vascular Endothelial Growth Factor; Temozolomide; Tumor Cells, Cultured	2003
Expression profiling of blood samples from an SU5416 Phase III metastatic colorectal cancer clinical trial: a novel strategy for biomarker identification. BMC cancer, 2003, Feb-07, Volume: 3 Topics: Aged; Angiogenesis Inhibitors; Antigens, CD; Biomarkers, Tumor; CD24 Antigen; Clinical Trials, Phase III as Topic; Colorectal Neoplasms; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Indoles; Lactoferrin; Leukocytes, Mononuclear; Male; Matrix Metalloproteinase 9; Membrane Glycoproteins; Middle Aged; Neoplasm Metastasis; Oligonucleotide Array Sequence Analysis; Predictive Value of Tests; Protein-Tyrosine Kinases; Pyrroles; Reverse Transcriptase Polymerase Chain Reaction	2003
Vascular endothelial growth factor (VEGF) receptor-2 signaling mediates VEGF-C(deltaNdeltaC)- and VEGF-A-induced angiogenesis in vitro. Experimental cell research, 2003, May-01, Volume: 285, Issue:2 Topics: Animals; Antibodies; Cattle; Cell Movement; Cells, Cultured; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Inhibitors; Fibrinolysin; Indoles; Mitogen-Activated Protein Kinases; Mutation; Neovascularization, Physiologic; Plasminogen Activators; Pyrroles; Signal Transduction; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor C; Vascular Endothelial Growth Factor Receptor-2	2003
Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors. The Journal of clinical investigation, 2003, Volume: 111, Issue:9 Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Combined Chemotherapy Protocols; Blood Vessels; Carcinoma, Islet Cell; Endothelium, Vascular; Female; Indoles; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neovascularization, Pathologic; Oxindoles; Pericytes; Platelet-Derived Growth Factor; Propionates; Protein-Tyrosine Kinases; Pyrroles; Receptors, Platelet-Derived Growth Factor; Receptors, Vascular Endothelial Growth Factor	2003
Influence of VEGF-R2 inhibition on MMP secretion and motility of microvascular human cerebral endothelial cells (HCEC). Journal of neuro-oncology, 2003, Volume: 62, Issue:3 Topics: Angiogenesis Inhibitors; Brain Neoplasms; Cell Movement; Cerebral Cortex; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Glioblastoma; Humans; Immunoenzyme Techniques; In Vitro Techniques; Indoles; Interleukin-10; Matrix Metalloproteinases; Microcirculation; Neovascularization, Pathologic; Protein-Tyrosine Kinases; Pyrroles; Spheroids, Cellular; Tumor Cells, Cultured; Umbilical Veins; Vascular Endothelial Growth Factor Receptor-2	2003
SU5416 sensitizes ovarian cancer cells to cisplatin through inhibition of nucleotide excision repair. Cellular and molecular life sciences : CMLS, 2003, Volume: 60, Issue:4 Topics: Carcinoma; Cisplatin; DNA Damage; DNA Repair; DNA-Binding Proteins; Endonucleases; Enzyme Inhibitors; Female; Humans; In Vitro Techniques; Indoles; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinases; Ovarian Neoplasms; Proteins; Proto-Oncogene Proteins c-jun; Pyrroles; Transcription Factor AP-1; Tumor Cells, Cultured	2003
Treatment of von Hippel-Lindau retinal hemangioblastoma by the vascular endothelial growth factor receptor inhibitor SU5416 is more effective for associated macular edema than for hemangioblastomas. American journal of ophthalmology, 2003, Volume: 136, Issue:1 Topics: Adult; Angiogenesis Inhibitors; Female; Fluorescein Angiography; Hemangioblastoma; Humans; Indoles; Infusions, Intravenous; Macular Edema; Pyrroles; Receptors, Vascular Endothelial Growth Factor; Retinal Neoplasms; Visual Acuity; von Hippel-Lindau Disease	2003
SU5416 and SU6668 attenuate the angiogenic effects of radiation-induced tumor cell growth factor production and amplify the direct anti-endothelial action of radiation in vitro. Cancer research, 2003, Jul-01, Volume: 63, Issue:13 Topics: Angiogenesis Inhibitors; Cell Division; Cells, Cultured; Dose-Response Relationship, Radiation; Endothelial Growth Factors; Endothelium, Vascular; Fibroblast Growth Factor 2; Humans; Indoles; Intercellular Signaling Peptides and Proteins; Kinetics; Lymphokines; Male; Neoplasm Invasiveness; Neovascularization, Pathologic; Oxindoles; Particle Accelerators; Propionates; Prostatic Neoplasms; Pyrroles; Reverse Transcriptase Polymerase Chain Reaction; Tumor Cells, Cultured; Umbilical Veins; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; X-Rays	2003
Combining antiangiogenic agents with metronomic chemotherapy enhances efficacy against late-stage pancreatic islet carcinomas in mice. Cold Spring Harbor symposia on quantitative biology, 2002, Volume: 67 Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Carcinoma, Islet Cell; Chronotherapy; Indoles; Matrix Metalloproteinase Inhibitors; Mice; Neovascularization, Pathologic; Pancreatic Neoplasms; Phenylalanine; Protease Inhibitors; Pyrroles; Receptors, Vascular Endothelial Growth Factor; Thiophenes	2002
Research retreat: Pfizer eliminates Sugen, shrinks cancer infrastructure. Journal of the National Cancer Institute, 2003, Jul-16, Volume: 95, Issue:14 Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Biomedical Research; Drug Design; Drug Industry; Drugs, Investigational; Endothelial Growth Factors; Erlotinib Hydrochloride; Germany; Humans; Indoles; Intercellular Signaling Peptides and Proteins; Lymphokines; Neoplasms; Pyrroles; Quinazolines; Signal Transduction; United States; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors	2003
Arginine deiminase and other antiangiogenic agents inhibit unfavorable neuroblastoma growth: potentiation by irradiation. International journal of cancer, 2003, Sep-20, Volume: 106, Issue:5 Topics: Angiogenesis Inhibitors; Animals; Cell Division; Cell Hypoxia; Combined Modality Therapy; Endothelium, Vascular; Gene Expression Regulation, Neoplastic; Humans; Hydrolases; Indoles; Mice; Mice, Nude; Neuroblastoma; Protein-Tyrosine Kinases; Pyrroles; Tumor Cells, Cultured; Whole-Body Irradiation; Xenograft Model Antitumor Assays	2003
SU5416 selectively impairs angiogenesis to induce prostate cancer-specific apoptosis. Molecular cancer therapeutics, 2003, Volume: 2, Issue:7 Topics: Angiogenesis Inhibitors; Animals; Apoptosis; Cell Differentiation; Disease Models, Animal; Disease Progression; Drug Evaluation, Preclinical; Gene Expression Regulation, Neoplastic; Indoles; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microcirculation; Neovascularization, Pathologic; Prostatic Neoplasms; Protein-Tyrosine Kinases; Pyrroles; Up-Regulation; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2	2003
[From molecular biology to new treatment approaches to colorectal cancer: basic research, experimental trials and surgical implications]. Il Giornale di chirurgia, 2003, Volume: 24, Issue:4 Topics: Adenomatous Polyposis Coli; Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Apoptosis; Cetuximab; Clinical Trials as Topic; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Colorectal Neoplasms; Colorectal Neoplasms, Hereditary Nonpolyposis; ErbB Receptors; Follow-Up Studies; Gefitinib; Genes, APC; Genes, DCC; Genes, p53; Genes, ras; Humans; Indoles; Mutation; Prognosis; Protein-Tyrosine Kinases; Pyrroles; Quinazolines; Receptors, Vascular Endothelial Growth Factor; Research; Time Factors	2003
Importance of vascular endothelial growth factor A in the progression of experimental neuroblastoma. Angiogenesis, 2002, Volume: 5, Issue:4 Topics: Angiogenesis Inhibitors; Animals; Cell Division; Endothelial Growth Factors; Female; Humans; Indoles; Male; Mice; Mice, Nude; Neoplasms, Experimental; Neuroblastoma; Protein-Tyrosine Kinases; Pyrroles; Transplantation, Heterologous; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A	2002
Suppression of experimental choroidal neovascularization utilizing KDR selective receptor tyrosine kinase inhibitor. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2003, Volume: 241, Issue:9 Topics: Animals; Cattle; Cell Division; Cells, Cultured; Choroidal Neovascularization; Endothelium, Corneal; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Indoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neovascularization, Physiologic; Phosphorylation; Protein-Tyrosine Kinases; Pyrroles; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2	2003
Analysis of prothrombotic mechanisms and endothelial perturbation during treatment with angiogenesis inhibitors. Pathophysiology of haemostasis and thrombosis, 2003, Volume: 33 Suppl 1 Topics: Angiogenesis Inhibitors; Endothelium, Vascular; Humans; Indoles; Neoplasms; Pyrroles; Thromboembolism; Thrombophilia; Treatment Outcome	2003
Potential inhibitors of angiogenesis. Part I: 3-(imidazol-4(5)-ylmethylene)indolin-2-ones. Journal of enzyme inhibition and medicinal chemistry, 2003, Volume: 18, Issue:3 Topics: Angiogenesis Inhibitors; Animals; Aorta; Cells, Cultured; Endothelium, Vascular; ErbB Receptors; Humans; Indoles; Male; Methylation; Models, Chemical; Nitrogen; Protein-Tyrosine Kinases; Pyrroles; Rats; Rats, Inbred F344	2003
Potential inhibitors of angiogenesis. Part II: 3-(azolylmethylene)-2,3-dihydrobenzo[b]furan-2-ones. Journal of enzyme inhibition and medicinal chemistry, 2003, Volume: 18, Issue:3 Topics: Angiogenesis Inhibitors; Animals; Aorta; Cells, Cultured; Endothelium, Vascular; Indoles; Magnetic Resonance Spectroscopy; Male; Models, Chemical; Pyrroles; Rats; Rats, Inbred F344; Temperature	2003
Plasma and cerebrospinal fluid pharmacokinetics of SU5416 after intravenous administration in nonhuman primates. Cancer chemotherapy and pharmacology, 2004, Volume: 53, Issue:1 Topics: Animals; Area Under Curve; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Half-Life; Indoles; Infusions, Intravenous; Macaca mulatta; Male; Protein-Tyrosine Kinases; Pyrroles	2004
Human NADPH-cytochrome p450 reductase overexpression does not enhance the aerobic cytotoxicity of doxorubicin in human breast cancer cell lines. Cancer research, 2003, Oct-15, Volume: 63, Issue:20 Topics: Aerobiosis; Antibiotics, Antineoplastic; Breast Neoplasms; Cell Line, Tumor; Doxorubicin; Humans; Indoles; NADPH-Ferrihemoprotein Reductase; Pyrroles; Transfection	2003
The antiangiogenic agent SU5416 down-regulates phorbol ester-mediated induction of cyclooxygenase 2 expression by inhibiting nicotinamide adenine dinucleotide phosphate oxidase activity. Cancer research, 2003, Oct-15, Volume: 63, Issue:20 Topics: Angiogenesis Inhibitors; Carcinoma, Non-Small-Cell Lung; Cyclooxygenase 2; Down-Regulation; Drug Interactions; Enzyme Induction; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Indoles; Isoenzymes; Lung Neoplasms; Membrane Proteins; NADPH Oxidases; Prostaglandin-Endoperoxide Synthases; Pyrroles; Superoxides; Tetradecanoylphorbol Acetate	2003
Growth factor-independent activation of protein kinase B contributes to the inherent resistance of vascular endothelium to radiation-induced apoptotic response. Cancer research, 2003, Nov-15, Volume: 63, Issue:22 Topics: Apoptosis; Caspase 3; Caspase 9; Caspase Inhibitors; Caspases; Cells, Cultured; Cytochromes c; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Growth Substances; Humans; Indoles; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyrroles; Radiation Tolerance; Signal Transduction	2003
Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2004, Volume: 18, Issue:2 Topics: Animals; Apoptosis; Cell Survival; Hypoxia; Indoles; Microcirculation; Models, Biological; Neoplasms; Neovascularization, Pathologic; Oxindoles; Pericytes; Platelet-Derived Growth Factor; Propionates; Pyrroles; Receptor, Platelet-Derived Growth Factor beta; Signal Transduction; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2	2004
Combined therapy with direct and indirect angiogenesis inhibition results in enhanced antiangiogenic and antitumor effects. Cancer research, 2003, Dec-15, Volume: 63, Issue:24 Topics: Adenocarcinoma; Angiogenesis Inhibitors; Animals; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Division; Cell Movement; Cell Survival; Drug Synergism; Endostatins; Endothelium, Vascular; Female; Glioblastoma; Humans; Indoles; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Mice, SCID; Neoplasms; Neovascularization, Pathologic; Prostatic Neoplasms; Pyrroles; Ultrasonography; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays	2003
The neural tube patterns vessels developmentally using the VEGF signaling pathway. Development (Cambridge, England), 2004, Volume: 131, Issue:7 Topics: Angiogenesis Inhibitors; Animals; Blood Vessels; Body Patterning; Central Nervous System; Chimera; Coculture Techniques; Culture Techniques; Female; Gestational Age; Indoles; Male; Mesoderm; Mice; Mice, Inbred Strains; Neovascularization, Physiologic; Pyrroles; Quail; Signal Transduction; Transplants; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2	2004
The c-Cbl/CD2AP complex regulates VEGF-induced endocytosis and degradation of Flt-1 (VEGFR-1). FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2004, Volume: 18, Issue:7 Topics: 3T3 Cells; Adaptor Proteins, Vesicular Transport; Animals; Binding Sites; Cells, Cultured; Endocytosis; Endothelial Cells; Humans; Indoles; Liver; Macromolecular Substances; Mice; Phosphorylation; Protein Binding; Protein Processing, Post-Translational; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Pyrroles; Rats; Recombinant Fusion Proteins; src Homology Domains; Tyrosine; Ubiquitin; Ubiquitin-Protein Ligases; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1	2004
Inhaled nitric oxide attenuates pulmonary hypertension and improves lung growth in infant rats after neonatal treatment with a VEGF receptor inhibitor. American journal of physiology. Lung cellular and molecular physiology, 2004, Volume: 287, Issue:2 Topics: Administration, Inhalation; Animals; Animals, Newborn; Bronchopulmonary Dysplasia; Enzyme Inhibitors; Female; Humans; Hypertension, Pulmonary; Indoles; Infant, Newborn; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Pregnancy; Pulmonary Alveoli; Pyrroles; Rats; Receptors, Vascular Endothelial Growth Factor	2004
Liver regeneration in FGF-2-deficient mice: VEGF acts as potential functional substitute for FGF-2. Liver international : official journal of the International Association for the Study of the Liver, 2004, Volume: 24, Issue:2 Topics: Angiogenesis Inhibitors; Animals; Fibroblast Growth Factor 2; Hepatectomy; Homozygote; Indoles; Injections, Intraperitoneal; Liver Regeneration; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neovascularization, Pathologic; Pyrroles; RNA, Messenger; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2	2004
Zebrafish: a preclinical model for drug screening. Assay and drug development technologies, 2002, Volume: 1, Issue:1 Pt 1 Topics: Acridine Orange; Alkaline Phosphatase; Angiogenesis Inhibitors; Animals; Apoptosis; Biological Assay; Drug Evaluation, Preclinical; Embryo, Nonmammalian; Flavonoids; Fluorescent Dyes; Indoles; Lethal Dose 50; Mice; Piperidines; Pyrroles; Toxicity Tests; Zebrafish	2002
Fibrinogen stimulates in vitro angiogenesis by choroidal endothelial cells via autocrine VEGF. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2004, Volume: 242, Issue:9 Topics: Angiogenesis Inhibitors; Animals; Blotting, Northern; Blotting, Western; Cattle; Cells, Cultured; Choroid; Choroidal Neovascularization; Endothelium, Vascular; Fibrinogen; Gene Expression; Hypoxia-Inducible Factor 1, alpha Subunit; Indoles; Protein-Tyrosine Kinases; Pyrroles; RNA, Messenger; Transcription Factors; Vascular Endothelial Growth Factor A	2004
The vascular endothelial growth factor (VEGF) receptor Flt-1 (VEGFR-1) modulates Flk-1 (VEGFR-2) signaling during blood vessel formation. The American journal of pathology, 2004, Volume: 164, Issue:5 Topics: Animals; Cell Differentiation; Cells, Cultured; Embryo, Mammalian; Indoles; Ligands; Mice; Mutation; Neovascularization, Physiologic; Phenotype; Phosphorylation; Pyrroles; Signal Transduction; Time Factors; Tyrosine; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2	2004
Determination of SU5416, a novel angiogenesis inhibitor, in human plasma by liquid chromatography. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2004, Jun-05, Volume: 805, Issue:1 Topics: Angiogenesis Inhibitors; Chromatography, High Pressure Liquid; Female; Humans; Indoles; Pyrroles; Reproducibility of Results; Spectrophotometry, Ultraviolet	2004
Simultaneous determination of Z-SU5416 and its interconvertible geometric E-isomer in rat plasma by LC/MS/MS. Journal of pharmaceutical and biomedical analysis, 2004, May-28, Volume: 35, Issue:3 Topics: Animals; Gas Chromatography-Mass Spectrometry; Indoles; Pyrroles; Rats; Stereoisomerism; Technology, Pharmaceutical	2004
New cancer therapeutics: target-specific in, cytotoxics out? Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy, 2004, Volume: 7, Issue:2 Topics: Antineoplastic Agents; Biomarkers, Tumor; Drug Delivery Systems; Enzyme Inhibitors; Gefitinib; Humans; Indoles; Intracellular Signaling Peptides and Proteins; Neoplasms; Proteomics; Pyrroles; Quinazolines; Sunitinib	2004
Mechanisms underlying the synergistic effect of SU5416 and cisplatin on cytotoxicity in human ovarian tumor cells. International journal of oncology, 2004, Volume: 25, Issue:2 Topics: Angiogenesis Inhibitors; Antineoplastic Agents; Apoptosis; Cell Cycle Proteins; Cell Line; Cisplatin; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Drug Synergism; Female; Humans; I-kappa B Proteins; Indoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase Kinases; NF-KappaB Inhibitor alpha; Ovarian Neoplasms; Proto-Oncogene Proteins; Pyrroles; Transcription Factor AP-1; Tumor Suppressor Protein p53; Tumor Suppressor Proteins; Up-Regulation	2004
SU5416 is a potent inhibitor of hepatocyte growth factor receptor (c-Met) and blocks HGF-induced invasiveness of human HepG2 hepatoma cells. Journal of hepatology, 2004, Volume: 41, Issue:2 Topics: 3T3 Cells; Animals; Carcinoma, Hepatocellular; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Endothelial Cells; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Gene Expression; Hepatocyte Growth Factor; Hepatocytes; Humans; Indoles; Liver Neoplasms; Mice; Neoplasm Invasiveness; Oncogene Proteins, Fusion; Phosphorylation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-met; Pyrroles; Tyrosine	2004
Vascular endothelial growth factor in diabetes induced early retinal abnormalities. Diabetes research and clinical practice, 2004, Volume: 65, Issue:3 Topics: Animals; Capillary Permeability; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Endothelin-1; Endothelin-3; Indoles; Male; MAP Kinase Signaling System; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrroles; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Vascular Endothelial Growth Factor A	2004
Antiangiogenic versus cytotoxic therapeutic approaches to human pancreas cancer: an experimental study with a vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor and gemcitabine. European journal of pharmacology, 2004, Sep-13, Volume: 498, Issue:1-3 Topics: Angiogenesis Inhibitors; Animals; Antimetabolites, Antineoplastic; Apoptosis; Cell Division; Cell Line; Cell Line, Tumor; Deoxycytidine; Dose-Response Relationship, Drug; Drug Synergism; Endothelial Cells; Female; Gemcitabine; Humans; Immunohistochemistry; Indoles; Male; Mice; Mice, Nude; Neovascularization, Pathologic; Pancreatic Neoplasms; Placenta; Pregnancy; Protein Kinase Inhibitors; Pyrroles; Time Factors; Tissue Culture Techniques; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2; Xenograft Model Antitumor Assays	2004
c-Myc interacts with hypoxia to induce angiogenesis in vivo by a vascular endothelial growth factor-dependent mechanism. Cancer research, 2004, Sep-15, Volume: 64, Issue:18 Topics: Animals; Cell Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Indoles; Keratinocytes; Mice; Neovascularization, Physiologic; Oxindoles; Papilloma; Precancerous Conditions; Propionates; Proto-Oncogene Proteins c-myc; Pyrroles; RNA, Messenger; Skin; Skin Neoplasms; Tamoxifen; Transcription Factors; Transgenes; Vascular Endothelial Growth Factor A	2004
SU5416 inhibited VEGF and HIF-1alpha expression through the PI3K/AKT/p70S6K1 signaling pathway. Biochemical and biophysical research communications, 2004, Nov-12, Volume: 324, Issue:2 Topics: Binding Sites; Blotting, Northern; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoblotting; Indoles; Luciferases; Neovascularization, Pathologic; Ovarian Neoplasms; Phosphatidylinositol 3-Kinases; Phosphorylation; Plasmids; Protein Binding; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyrroles; Ribosomal Protein S6 Kinases, 70-kDa; RNA; RNA, Messenger; Signal Transduction; Tetrazolium Salts; Thiazoles; Time Factors; Transcription Factors; Transcriptional Activation; Transfection; Up-Regulation; Vascular Endothelial Growth Factor A	2004
Triple combination of irradiation, chemotherapy (pemetrexed), and VEGFR inhibition (SU5416) in human endothelial and tumor cells. International journal of radiation oncology, biology, physics, 2004, Nov-15, Volume: 60, Issue:4 Topics: Angiogenesis Inhibitors; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Combined Modality Therapy; Endothelial Cells; Glutamates; Guanine; Humans; Indoles; Neoplasms; Neovascularization, Pathologic; Pemetrexed; Protein-Tyrosine Kinases; Pyrroles; Tumor Stem Cell Assay	2004
The multi-targeted kinase inhibitor SU5416 inhibits small cell lung cancer growth and angiogenesis, in part by blocking Kit-mediated VEGF expression. Lung cancer (Amsterdam, Netherlands), 2004, Volume: 46, Issue:3 Topics: Animals; Carcinoma, Small Cell; Drug Resistance, Neoplasm; Female; Humans; Indoles; Lung Neoplasms; Mice; Mice, Nude; Neovascularization, Pathologic; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Pyrroles; Transplantation, Heterologous; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A	2004
Differential roles of vascular endothelial growth factor receptors 1 and 2 in dendritic cell differentiation. Journal of immunology (Baltimore, Md. : 1950), 2005, Jan-01, Volume: 174, Issue:1 Topics: Animals; Antigens, CD34; Blotting, Western; Bone Marrow Cells; Cell Differentiation; Cells, Cultured; Dendritic Cells; Embryo, Mammalian; Enzyme Inhibitors; Female; Hematopoietic Stem Cells; Humans; Indoles; Lymphocyte Culture Test, Mixed; Mice; NF-kappa B; Pyrroles; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2	2005
Irradiation combined with SU5416: microvascular changes and growth delay in a human xenograft glioblastoma tumor line. International journal of radiation oncology, biology, physics, 2005, Feb-01, Volume: 61, Issue:2 Topics: Angiogenesis Inhibitors; Animals; Cell Hypoxia; Cell Line, Tumor; Combined Modality Therapy; Dose-Response Relationship, Radiation; Drug Screening Assays, Antitumor; Glioblastoma; Humans; Indoles; Mice; Mice, Inbred BALB C; Mice, Nude; Microcirculation; Necrosis; Pyrroles; Recurrence; Remission Induction; Transplantation, Heterologous	2005
Pharmacodynamic analysis of target inhibition and endothelial cell death in tumors treated with the vascular endothelial growth factor receptor antagonists SU5416 or SU6668. Clinical cancer research : an official journal of the American Association for Cancer Research, 2005, Jan-15, Volume: 11, Issue:2 Pt 1 Topics: Adult; Aged; Aged, 80 and over; Animals; Apoptosis; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; Humans; Indoles; Male; Mice; Mice, Nude; Middle Aged; Neovascularization, Pathologic; Oxindoles; Pancreatic Neoplasms; Phosphorylation; Propionates; Pyrroles; Receptor, Platelet-Derived Growth Factor beta; Transplantation, Heterologous; Vascular Endothelial Growth Factor Receptor-2	2005
Inhibition of VEGF receptor-2 decreases the development of hyperdynamic splanchnic circulation and portal-systemic collateral vessels in portal hypertensive rats. Journal of hepatology, 2005, Volume: 43, Issue:1 Topics: Angiogenesis Inhibitors; Animals; Arterioles; Collateral Circulation; Hemodynamics; Hypertension, Portal; Indoles; Male; Neovascularization, Pathologic; Platelet Endothelial Cell Adhesion Molecule-1; Portal System; Portal Vein; Protein Kinase Inhibitors; Pyrroles; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Splanchnic Circulation; Vascular Endothelial Growth Factor Receptor-2; Vascular Resistance	2005
Initial apoptosis is followed by increased proliferation of apoptosis-resistant endothelial cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2005, Volume: 19, Issue:9 Topics: Apoptosis; bcl-X Protein; Caspase 3; Caspase Inhibitors; Caspases; Caveolin 1; Cell Line; Cell Proliferation; Cycloheximide; Endothelial Cells; Humans; Hypertension, Pulmonary; Indoles; Pyrroles; Receptors, Vascular Endothelial Growth Factor; Shear Strength; Tumor Necrosis Factor-alpha	2005
Case 2. Hemangioblastomas: diagnosis of von Hippel-Lindau disease and antiangiogenic treatment with SU5416. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2005, May-20, Volume: 23, Issue:15 Topics: Angiogenesis Inhibitors; Biopsy, Needle; Cerebellar Neoplasms; Diagnosis, Differential; Follow-Up Studies; Hemangioblastoma; Humans; Immunohistochemistry; Indoles; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Recurrence, Local; Pyrroles; Risk Assessment; Treatment Outcome; von Hippel-Lindau Disease	2005
Simultaneous determination of Z-3-[(2,4-dimethylpyrrol-5-yl)methylidenyl]-2-indolinone (SU5416) and its interconvertible geometric isomer (SU5886) in rat plasma by LC/MS/MS. Journal of pharmaceutical and biomedical analysis, 2005, Jul-01, Volume: 38, Issue:3 Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents, Alkylating; Calibration; Chromatography, High Pressure Liquid; Drug Evaluation, Preclinical; Drug Stability; Drugs, Investigational; Humans; Indoles; Mass Spectrometry; Pyrroles; Rats; Reference Standards; Reproducibility of Results; Stereoisomerism	2005
In vitro procoagulant activity induced in endothelial cells by chemotherapy and antiangiogenic drug combinations: modulation by lower-dose chemotherapy. Cancer research, 2005, Jun-15, Volume: 65, Issue:12 Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Blood Coagulation; Cells, Cultured; Cisplatin; Deoxycytidine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Synergism; Endothelial Cells; Gemcitabine; Humans; Indoles; Oxindoles; Piperidines; Propionates; Pyrroles; Quinazolines; Thromboplastin	2005
Nerve growth factor-induced migration of endothelial cells. The Journal of pharmacology and experimental therapeutics, 2005, Volume: 315, Issue:3 Topics: Adrenal Medulla; Animals; Aorta; Carbazoles; Cell Line; Cell Movement; Dose-Response Relationship, Drug; Drug Interactions; Endothelial Cells; Endothelium, Vascular; Enzyme Inhibitors; Fibroblast Growth Factor 2; Humans; Indole Alkaloids; Indoles; Mice; Models, Biological; Nerve Growth Factor; Pyrroles; Rats; Receptor, Nerve Growth Factor; Receptor, trkA; Recombinant Proteins; Reproducibility of Results; Time Factors; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2; Viperidae	2005
Combined inhibition of vascular endothelial growth factor (VEGF), fibroblast growth factor and platelet-derived growth factor, but not inhibition of VEGF alone, effectively suppresses angiogenesis and vessel maturation in endometriotic lesions. Human reproduction (Oxford, England), 2006, Volume: 21, Issue:1 Topics: Angiogenesis Inhibitors; Animals; Capillaries; Cricetinae; Endometriosis; Endometrium; Female; Fibroblast Growth Factors; Indoles; Mesocricetus; Neovascularization, Pathologic; Oxindoles; Platelet-Derived Growth Factor; Propionates; Protein Kinase Inhibitors; Pyrroles; Uterine Diseases; Vascular Endothelial Growth Factor A	2006
Functional CT for quantifying tumor perfusion in antiangiogenic therapy in a rat model. Radiology, 2005, Volume: 237, Issue:1 Topics: Angiogenesis Inhibitors; Animals; Female; Indoles; Liver Neoplasms, Experimental; Microcirculation; Protein Kinase Inhibitors; Pyrroles; Random Allocation; Rats; Rats, Inbred F344; Tomography, X-Ray Computed	2005
Conformationally restricted analogs of Combretastatin A-4 derived from SU5416. Bioorganic & medicinal chemistry letters, 2005, Dec-15, Volume: 15, Issue:24 Topics: Animals; Antineoplastic Agents; Brain; Cell Division; Indoles; Models, Molecular; Molecular Conformation; Pyrroles; Stilbenes; Swine; Tubulin	2005
Molecular mechanisms of hepatic metastasis in colorectal cancer. Journal of surgical oncology, 2005, Dec-15, Volume: 92, Issue:4 Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Cetuximab; Colorectal Neoplasms; Hepatectomy; Humans; Indoles; Liver Neoplasms; Prognosis; Pyrroles; Receptors, Vascular Endothelial Growth Factor; Survival Rate	2005
Reversible Z-E isomerism and pharmaceutical implications for SU5416. Drug development and industrial pharmacy, 2005, Volume: 31, Issue:10 Topics: Algorithms; Angiogenesis Inhibitors; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Excipients; Half-Life; Humans; In Vitro Techniques; Indoles; Isomerism; Kinetics; Plasma; Pyrroles; Quality Control; Structure-Activity Relationship	2005
Vascular endothelial growth factor receptor blockade by SU5416 combined with pulsatile shear stress causes apoptosis and subsequent proliferation of apoptosis-resistant endothelial cells. Chest, 2005, Volume: 128, Issue:6 Suppl Topics: Angiogenesis Inhibitors; Apoptosis; Cells, Cultured; Endothelial Cells; Humans; Indoles; Pulmonary Artery; Pyrroles; Receptors, Vascular Endothelial Growth Factor; Stress, Mechanical	2005
Inhibition of vascular endothelial growth factor receptor 2 activity in experimental brain contusions aggravates injury outcome and leads to early increased neuronal and glial degeneration. The European journal of neuroscience, 2006, Volume: 23, Issue:1 Topics: Angiogenesis Inhibitors; Animals; Brain Injuries; Cell Count; Cell Death; Disease Models, Animal; Female; Fluoresceins; Glial Fibrillary Acidic Protein; Immunosorbent Techniques; In Situ Hybridization; In Situ Nick-End Labeling; Indoles; Microtubule-Associated Proteins; Myelin-Associated Glycoprotein; Nerve Degeneration; Nerve Growth Factors; Neuroglia; Organic Chemicals; Pyrroles; Rats; Rats, Sprague-Dawley; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Time Factors; Vascular Endothelial Growth Factor Receptor-2	2006
High-performance liquid chromatographic method for determination of reversible isomers of SU5416. Journal of chromatography. A, 2006, Mar-31, Volume: 1110, Issue:1-2 Topics: Calibration; Chromatography, High Pressure Liquid; Indoles; Isomerism; Kinetics; Pyrroles; Reproducibility of Results; Sensitivity and Specificity; Technology, Pharmaceutical	2006
Antiangiogenic combination tumor therapy blocking alpha(v)-integrins and VEGF-receptor-2 increases therapeutic effects in vivo. International journal of cancer, 2006, Jul-15, Volume: 119, Issue:2 Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Combined Chemotherapy Protocols; Cricetinae; Disease Progression; Indoles; Integrin alphaV; Male; Mesocricetus; Microcirculation; Neoplasm Metastasis; Neoplasm Recurrence, Local; Neovascularization, Pathologic; Pyrroles; Vascular Endothelial Growth Factor Receptor-2	2006
VEGF-C promotes survival in podocytes. American journal of physiology. Renal physiology, 2006, Volume: 291, Issue:1 Topics: Calcium; Cell Line; Cell Survival; Endothelial Cells; Humans; Immunoprecipitation; Indoles; Kidney Glomerulus; Mitogen-Activated Protein Kinase Kinases; Naphthalenes; Phosphorylation; Podocytes; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrroles; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor C; Vascular Endothelial Growth Factor D	2006
Mild increases in portal pressure upregulate vascular endothelial growth factor and endothelial nitric oxide synthase in the intestinal microcirculatory bed, leading to a hyperdynamic state. American journal of physiology. Gastrointestinal and liver physiology, 2006, Volume: 290, Issue:5 Topics: Angiogenesis Inhibitors; Animals; Endothelium, Vascular; Hypertension, Portal; Indoles; Intestinal Mucosa; Intestines; Jejunum; Male; Microcirculation; Neovascularization, Pathologic; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Portal Pressure; Pyrroles; Rats; Up-Regulation; Vascular Endothelial Growth Factor A; Vasodilation	2006
Novel bis(1H-indol-2-yl)methanones as potent inhibitors of FLT3 and platelet-derived growth factor receptor tyrosine kinase. Journal of medicinal chemistry, 2006, Jun-01, Volume: 49, Issue:11 Topics: Acute Disease; Animals; Antineoplastic Agents; Apoptosis; Binding Sites; Cell Line; Cell Line, Tumor; fms-Like Tyrosine Kinase 3; Humans; In Vitro Techniques; Indoles; Leukemia, Myeloid; Ligands; Mice; Models, Molecular; Phosphorylation; Pyrroles; Receptors, Platelet-Derived Growth Factor; Structure-Activity Relationship	2006
An orally administered multitarget tyrosine kinase inhibitor, SU11248, is a novel potent inhibitor of thyroid oncogenic RET/papillary thyroid cancer kinases. The Journal of clinical endocrinology and metabolism, 2006, Volume: 91, Issue:10 Topics: Administration, Oral; Animals; Antineoplastic Agents; Cell Proliferation; Humans; Indoles; Mice; NIH 3T3 Cells; Oxindoles; Phosphorylation; Propionates; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-ret; Pyrroles; STAT3 Transcription Factor; Sunitinib	2006
Structure-activity-relationship studies of conformationally restricted analogs of combretastatin A-4 derived from SU5416. Bioorganic & medicinal chemistry, 2006, Oct-01, Volume: 14, Issue:19 Topics: Antineoplastic Agents, Phytogenic; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chromatography, High Pressure Liquid; DNA, Neoplasm; Drug Screening Assays, Antitumor; Female; Humans; Indoles; Isomerism; Magnetic Resonance Spectroscopy; Molecular Conformation; Podophyllotoxin; Pyrroles; Stilbenes; Structure-Activity Relationship; Tubulin	2006
Blockade of vascular endothelial growth factor signaling ameliorates diabetic albuminuria in mice. Journal of the American Society of Nephrology : JASN, 2006, Volume: 17, Issue:11 Topics: Albuminuria; Animals; Diabetic Nephropathies; Indoles; Male; Mice; Mice, Inbred C57BL; Protein Kinase Inhibitors; Pyrroles; Vascular Endothelial Growth Factor A	2006
N-acetylcysteine treatment protects against VEGF-receptor blockade-related emphysema. COPD, 2004, Volume: 1, Issue:1 Topics: Acetylcysteine; Animals; Apoptosis; Disease Models, Animal; Dose-Response Relationship, Drug; Emphysema; Heme Oxygenase-1; Hypertrophy, Right Ventricular; Indoles; Lung; Male; Oxidative Stress; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Vascular Endothelial Growth Factor	2004
Mechanism of reoxygenation after antiangiogenic therapy using SU5416 and its importance for guiding combined antitumor therapy. Cancer research, 2006, Oct-01, Volume: 66, Issue:19 Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Hypoxia; Combined Modality Therapy; Cyclophosphamide; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Fibrosarcoma; Indoles; Liver Neoplasms, Experimental; Mice; Mice, Inbred C3H; Mitochondria; Oxygen; Oxygen Consumption; Pyrroles; Radiation-Sensitizing Agents	2006
Inhibition of RET tyrosine kinase by SU5416. Journal of molecular endocrinology, 2006, Volume: 37, Issue:2 Topics: Animals; Carcinoma, Papillary; Female; Humans; Indoles; Insecta; Mice; Mice, Nude; Models, Biological; Models, Molecular; Mutant Proteins; NIH 3T3 Cells; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Proto-Oncogene Mas; Proto-Oncogene Proteins c-ret; Pyrroles; Sensitivity and Specificity; Thyroid Neoplasms; Tumor Cells, Cultured; Xenograft Model Antitumor Assays	2006
Fatal hepatorenal failure and thrombocytopenia with SU5416, a vascular endothelial growth factor Flk-1 receptor inhibitor, in AIDS-Kaposi's sarcoma. AIDS (London, England), 2007, Jan-02, Volume: 21, Issue:1 Topics: Acquired Immunodeficiency Syndrome; Angiogenesis Inhibitors; Fatal Outcome; Humans; Indoles; Liver Failure; Male; Middle Aged; Pyrroles; Renal Insufficiency; Sarcoma, Kaposi; Skin Neoplasms	2007
Semaxinib (SU5416) as a therapeutic agent targeting oncogenic Kit mutants resistant to imatinib mesylate. Oncogene, 2007, May-31, Volume: 26, Issue:26 Topics: Animals; Antineoplastic Agents; Apoptosis; Benzamides; Blotting, Western; Cell Proliferation; Drug Resistance, Neoplasm; Enzyme Activation; Erythroblasts; Extracellular Signal-Regulated MAP Kinases; Humans; Imatinib Mesylate; Indoles; Mice; Mice, Transgenic; Mutation; Oncogene Protein v-akt; Piperazines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; STAT3 Transcription Factor; Stem Cell Factor	2007
Synthesis and evaluation of prodrugs for anti-angiogenic pyrrolylmethylidenyl oxindoles. Bioorganic & medicinal chemistry letters, 2007, Mar-15, Volume: 17, Issue:6 Topics: Angiogenesis Inhibitors; Cells, Cultured; Endothelium, Vascular; Humans; Indoles; Magnetic Resonance Spectroscopy; Prodrugs; Pyrroles; Structure-Activity Relationship; Vascular Endothelial Growth Factor A	2007
Effects of vascular endothelial growth factor receptor inhibitor SU5416 and prostacyclin on murine lung metastasis. Anti-cancer drugs, 2007, Volume: 18, Issue:3 Topics: Animals; Carcinoma, Lewis Lung; Cell Adhesion; Cells, Cultured; Disease Progression; Epoprostenol; Indoles; Liver Neoplasms; Lung Neoplasms; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Neoplasm Transplantation; Pyrroles; Receptors, Vascular Endothelial Growth Factor; Splenic Neoplasms	2007
Rho kinase-mediated vasoconstriction is important in severe occlusive pulmonary arterial hypertension in rats. Circulation research, 2007, Mar-30, Volume: 100, Issue:6 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Disease Models, Animal; Disease Progression; Endothelin A Receptor Antagonists; Hypertension, Pulmonary; Hypoxia; Indoles; Intracellular Signaling Peptides and Proteins; Male; Myosin-Light-Chain Phosphatase; Organ Culture Techniques; Peptides, Cyclic; Phosphorylation; Protein Serine-Threonine Kinases; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Vascular Endothelial Growth Factor Receptor-2; Vasoconstriction; Vasodilator Agents	2007
Absence of T cells confers increased pulmonary arterial hypertension and vascular remodeling. American journal of respiratory and critical care medicine, 2007, Jun-15, Volume: 175, Issue:12 Topics: Adoptive Transfer; Angiogenesis Inhibitors; Animals; Dendritic Cells; Disease Models, Animal; Endothelial Cells; Homeostasis; Hypertension, Pulmonary; Immunohistochemistry; Indoles; Injections, Subcutaneous; Male; Pyrroles; Rats; Rats, Nude; Receptors, Vascular Endothelial Growth Factor; T-Lymphocytes	2007
Modulation of angiogenic phenotype alters tumorigenicity in rat ovarian epithelial cells. Cancer research, 2007, Apr-15, Volume: 67, Issue:8 Topics: Angiogenesis Inhibitors; Animals; Cell Growth Processes; Cell Transformation, Neoplastic; Endostatins; Female; Indoles; Neovascularization, Pathologic; Ovarian Neoplasms; Pyrroles; Rats; Transfection; Vascular Endothelial Growth Factor A	2007
VEGF receptor inhibition blocks liver cyst growth in pkd2(WS25/-) mice. American journal of physiology. Cell physiology, 2007, Volume: 293, Issue:1 Topics: Animals; Cell Proliferation; Cells, Cultured; Cyst Fluid; Cysts; Disease Models, Animal; Dose-Response Relationship, Drug; Epithelial Cells; Indoles; Liver; Liver Diseases; Mice; Mice, Inbred C57BL; Mice, Knockout; Polycystic Kidney, Autosomal Dominant; Protein Kinase Inhibitors; Pyrroles; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Time Factors; TRPP Cation Channels; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2	2007
Effect of chemical stabilizers of hypoxia-inducible factors on early lung development. American journal of physiology. Lung cellular and molecular physiology, 2007, Volume: 293, Issue:3 Topics: Amino Acids, Dicarboxylic; Animals; Chlorides; Cobalt; Deferoxamine; Dose-Response Relationship, Drug; Embryo, Mammalian; Epithelial Cells; Ferric Compounds; Hypoxia-Inducible Factor 1; In Vitro Techniques; Indoles; Lung; Mice; Morphogenesis; Neovascularization, Physiologic; Pyrroles; Signal Transduction; Vascular Endothelial Growth Factor Receptor-2	2007
Role of NADPH oxidase and ANG II in diabetes-induced retinal leukostasis. American journal of physiology. Regulatory, integrative and comparative physiology, 2007, Volume: 293, Issue:4 Topics: Acetophenones; Acetylcysteine; Angiogenesis Inhibitors; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antioxidants; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Imidazoles; Indoles; Leukostasis; Losartan; Male; NADPH Oxidases; Pyridines; Pyrroles; Rats; Reactive Oxygen Species; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Retinal Diseases; Vascular Endothelial Growth Factor A; Vasoconstrictor Agents	2007
Early inhaled nitric oxide treatment decreases apoptosis of endothelial cells in neonatal rat lungs after vascular endothelial growth factor inhibition. American journal of physiology. Lung cellular and molecular physiology, 2007, Volume: 293, Issue:5 Topics: Administration, Inhalation; Angiogenesis Inhibitors; Animals; Animals, Newborn; Apoptosis; Blotting, Western; Cell Proliferation; Endothelium, Vascular; Enzyme Inhibitors; Female; Indoles; Lung; Nitric Oxide; Nitric Oxide Synthase Type III; Pregnancy; Protein-Tyrosine Kinases; Pulmonary Alveoli; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Vascular Endothelial Growth Factor	2007
VEGF modulation of retinal pigment epithelium resistance. Experimental eye research, 2007, Volume: 85, Issue:6 Topics: Animals; Cell Line; Cell Membrane Permeability; Cells, Cultured; Dose-Response Relationship, Drug; Electric Impedance; Humans; Indoles; Pigment Epithelium of Eye; Pyrroles; Quinazolines; Retina; Sus scrofa; Tight Junctions; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2	2007
Impaired VEGF and nitric oxide signaling after nitrofen exposure in rat fetal lung explants. American journal of physiology. Lung cellular and molecular physiology, 2008, Volume: 294, Issue:1 Topics: Animals; Fetus; Indoles; Lung; Models, Animal; Nitric Oxide; Phenyl Ethers; Protein Kinase Inhibitors; Pyrroles; Rats; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Vascular Endothelial Growth Factor A	2008
Should tumor VEGF expression influence decisions on combining low-dose chemotherapy with antiangiogenic therapy? Preclinical modeling in ovarian cancer. Journal of translational medicine, 2008, Jan-08, Volume: 6 Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Dose-Response Relationship, Drug; Female; Humans; Indoles; Maximum Tolerated Dose; Mice; Mice, Inbred C57BL; Microcirculation; Ovarian Neoplasms; Paclitaxel; Pyrroles; Recombinant Proteins; Vascular Endothelial Growth Factor A	2008
Iodine deficiency induces a thyroid stimulating hormone-independent early phase of microvascular reshaping in the thyroid. The American journal of pathology, 2008, Volume: 172, Issue:3 Topics: Adaptation, Physiological; Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Bevacizumab; Fibroblast Growth Factors; Goiter; Indoles; Iodide Peroxidase; Iodine; Mice; Mice, Inbred Strains; Microcirculation; Neovascularization, Physiologic; Perchlorates; Pyrroles; Thyroid Function Tests; Thyroid Gland; Thyrotropin; Time Factors; Vascular Endothelial Growth Factor A	2008
Combination of vascular endothelial growth factor receptor/platelet-derived growth factor receptor inhibition markedly improves radiation tumor therapy. Clinical cancer research : an official journal of the American Association for Cancer Research, 2008, Apr-01, Volume: 14, Issue:7 Topics: Angiogenesis Inhibitors; Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Combined Modality Therapy; Endothelial Cells; Flow Cytometry; Humans; Immunohistochemistry; Indoles; Mice; Mice, Nude; Neoplasms; Neovascularization, Pathologic; Oxindoles; Propionates; Protein Kinase Inhibitors; Pyrroles; Radiation-Sensitizing Agents; Radiotherapy; Receptors, Platelet-Derived Growth Factor; Receptors, Vascular Endothelial Growth Factor; Reverse Transcriptase Polymerase Chain Reaction; Xenograft Model Antitumor Assays	2008
Antiangiogenic and anticolorectal cancer effects of metronomic irinotecan chemotherapy alone and in combination with semaxinib. British journal of cancer, 2008, May-20, Volume: 98, Issue:10 Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Camptothecin; Cell Proliferation; Colorectal Neoplasms; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation, Neoplastic; HT29 Cells; Humans; Immunoenzyme Techniques; Immunohistochemistry; Indoles; Irinotecan; Male; Mice; Mice, Nude; Microcirculation; Pyrroles; Thrombospondin 1; Transplantation, Heterologous; Vascular Endothelial Growth Factor A	2008
Transforming growth factor-beta1 protects against pulmonary artery endothelial cell apoptosis via ALK5. American journal of physiology. Lung cellular and molecular physiology, 2008, Volume: 295, Issue:1 Topics: Animals; Apoptosis; Caspase 12; Caspase 8; Cattle; Cell Survival; Emphysema; Endothelial Cells; Enzyme Activation; Humans; Indoles; Mitochondria; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-bcl-2; Pulmonary Artery; Pyrroles; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Smad Proteins; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha; Ultraviolet Rays	2008
Antiangiogenic cancer therapy using tumor vasculature-targeted liposomes encapsulating 3-(3,5-dimethyl-1H-pyrrol-2-ylmethylene)-1,3-dihydro-indol-2-one, SU5416. Cancer letters, 2008, Nov-08, Volume: 270, Issue:2 Topics: Angiogenesis Inhibitors; Animals; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Compounding; Drug Stability; Endothelial Cells; Hemolysis; Humans; Indoles; Lipids; Liposomes; Male; Mice; Mice, Inbred BALB C; Oligopeptides; Particle Size; Pyrroles; Solubility; Time Factors; Vascular Endothelial Growth Factor A	2008
VEGFR-2 antagonist SU5416 attenuates bleomycin-induced pulmonary fibrosis in mice. International immunopharmacology, 2009, Volume: 9, Issue:1 Topics: Angiogenesis Inhibitors; Animals; Antibiotics, Antineoplastic; Bleomycin; Blotting, Western; Bronchoalveolar Lavage Fluid; Flow Cytometry; Hydroxyproline; Indoles; Lung; Male; Mice; Mice, Inbred C57BL; Neovascularization, Pathologic; Pulmonary Fibrosis; Pyrroles; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Smad3 Protein; Transforming Growth Factor beta1; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2	2009
VEGFR1 receptor tyrosine kinase localization to the Golgi apparatus is calcium-dependent. Experimental cell research, 2009, Mar-10, Volume: 315, Issue:5 Topics: Calcium; Cell Membrane; Cells, Cultured; Endothelial Cells; Estrenes; Golgi Apparatus; Humans; Indoles; Protein Kinase Inhibitors; Protein Transport; Protein-Tyrosine Kinases; Pyrroles; Pyrrolidinones; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2	2009
VEGF and angiogenesis in acute and chronic MOG((35-55)) peptide induced EAE. Journal of neuroimmunology, 2009, Apr-30, Volume: 209, Issue:1-2 Topics: Angiogenesis Inhibitors; Angiogenic Proteins; Animals; Blood Vessels; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Glycoproteins; Indoles; Laminin; Mice; Mice, Inbred C57BL; Myelin Sheath; Myelin-Oligodendrocyte Glycoprotein; Neovascularization, Pathologic; Peptide Fragments; Pyrroles; RNA, Messenger; Spinal Cord; Up-Regulation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2; Wallerian Degeneration	2009
Oral administration of pyrrolidine dithiocarbamate (PDTC) inhibits VEGF expression, tumor angiogenesis, and growth of breast cancer in female mice. Cancer biology & therapy, 2009, Mar-15, Volume: 8, Issue:6 Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Drug Synergism; Estrogen Receptor alpha; Female; Gene Expression Regulation, Neoplastic; Humans; Indoles; Mice; Mice, Inbred C57BL; Neovascularization, Pathologic; NF-kappa B; Pyrroles; Pyrrolidines; Thiocarbamates; Tumor Burden; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2	2009
Vascular endothelial growth factor receptor inhibitor enhances dietary salt-induced hypertension in Sprague-Dawley rats. American journal of physiology. Regulatory, integrative and comparative physiology, 2009, Volume: 297, Issue:1 Topics: Albuminuria; Angiogenesis Inhibitors; Animals; Blood Pressure; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Endothelial Cells; Epithelial Cells; Heart Rate; Humans; Hypertension; Indoles; Injections, Intraperitoneal; Kidney; Kidney Glomerulus; Kidney Tubules, Proximal; Male; Natriuresis; Nitric Oxide; Nitric Oxide Synthase Type III; Protein Kinase Inhibitors; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Vascular Endothelial Growth Factor; Sodium Chloride, Dietary; Vascular Endothelial Growth Factor A	2009
Genetic evidence for a noncanonical function of seryl-tRNA synthetase in vascular development. Circulation research, 2009, Jun-05, Volume: 104, Issue:11 Topics: Angiogenesis Inhibitors; Animals; Aorta, Thoracic; Brain; Cell Division; Cerebrovascular Circulation; Chromosome Mapping; Cycloheximide; Embryo, Nonmammalian; Endothelium, Vascular; Heart; Humans; Indoles; Myocardium; Pyrroles; RNA, Small Interfering; Serine-tRNA Ligase; Transfection; Umbilical Veins; Zebrafish	2009
Reduction in endothelial tip cell filopodia corresponds to reduced intravitreous but not intraretinal vascularization in a model of ROP. Experimental eye research, 2009, Volume: 89, Issue:5 Topics: Angiogenesis Inhibitors; Animals; Animals, Newborn; Caspase 3; Cell Movement; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelial Cells; Humans; Indoles; Infant, Newborn; Integrin beta3; Neovascularization, Pathologic; Phosphorylation; Protein Kinase Inhibitors; Pseudopodia; Pyrroles; Rats; Rats, Sprague-Dawley; Retinal Vessels; Retinopathy of Prematurity; Time Factors; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2; Vitreous Body	2009
Liver cyst cytokines promote endothelial cell proliferation and development. Experimental biology and medicine (Maywood, N.J.), 2009, Volume: 234, Issue:10 Topics: Animals; Cell Proliferation; Cells, Cultured; Cyst Fluid; Cysts; Cytokines; Disease Models, Animal; Endothelial Cells; Endothelium, Vascular; Enzyme Inhibitors; Humans; Indoles; Liver Diseases; Mice; Mice, Inbred C57BL; Mice, Knockout; Neovascularization, Pathologic; NIMA-Interacting Peptidylprolyl Isomerase; Peptidylprolyl Isomerase; Phosphorylation; Polycystic Kidney, Autosomal Dominant; Pyrroles; TRPP Cation Channels; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2	2009
Ligation or cross-linking of CD40 has different effects on AGS gastric cancer cells. Cellular immunology, 2009, Volume: 259, Issue:2 Topics: Apoptosis; CD40 Antigens; CD40 Ligand; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Chromones; Flow Cytometry; Humans; Indoles; Morpholines; Nuclear Proteins; Protein Kinase Inhibitors; Pyrroles; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Small Interfering; Stomach Neoplasms; Vascular Endothelial Growth Factor A	2009
Inhibition of VEGF receptor 2 increased cell death of dentate hilar neurons after traumatic brain injury. Experimental neurology, 2009, Volume: 220, Issue:2 Topics: Animals; Brain Injuries; Cell Death; Dentate Gyrus; Fluoresceins; Fluorescent Dyes; Immunohistochemistry; In Situ Nick-End Labeling; Indoles; Injections, Intraventricular; Male; Neurons; Neuroprotective Agents; Organic Chemicals; Protein Kinase Inhibitors; Pyrroles; Rats; Rats, Sprague-Dawley; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2	2009
ERK1/2-dependent vascular endothelial growth factor signaling sustains cyst growth in polycystin-2 defective mice. Gastroenterology, 2010, Volume: 138, Issue:1 Topics: Animals; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Cysts; Hypoxia-Inducible Factor 1, alpha Subunit; Indoles; Liver Diseases; MAP Kinase Signaling System; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phenotype; Phosphorylation; Proliferating Cell Nuclear Antigen; Protein Kinase Inhibitors; Pyrroles; Repressor Proteins; TRPP Cation Channels; Tumor Suppressor Proteins; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2	2010
Vascular endothelial growth factor is a key mediator in the development of T cell priming and its polarization to type 1 and type 17 T helper cells in the airways. Journal of immunology (Baltimore, Md. : 1950), 2009, Oct-15, Volume: 183, Issue:8 Topics: Allergens; Animals; Apoptosis; Asthma; Immunity, Active; Immunity, Innate; Indoles; Inflammation; Interleukin-12; Interleukin-17; Interleukin-6; Lipopolysaccharides; Lung; Mice; Mice, Inbred BALB C; Mice, Knockout; Ovalbumin; Protein Kinase Inhibitors; Pyrroles; T-Lymphocytes, Helper-Inducer; Th1 Cells; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2	2009
Synthesis and radiopharmacological investigation of 3-[4'-[(18)F]fluorobenzylidene]indolin-2-one as possible tyrosine kinase inhibitor. Bioorganic & medicinal chemistry, 2009, Nov-15, Volume: 17, Issue:22 Topics: Animals; Cell Line, Tumor; Fluorine Radioisotopes; Humans; Indoles; Mice; Models, Chemical; Positron-Emission Tomography; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrroles; Radiopharmaceuticals; Rats; Rats, Wistar; Stereoisomerism	2009
Stimulation of sphingosine 1-phosphate signaling as an alveolar cell survival strategy in emphysema. American journal of respiratory and critical care medicine, 2010, Feb-15, Volume: 181, Issue:4 Topics: Animals; Apoptosis; Blotting, Western; Cells, Cultured; Ceramides; Disease Models, Animal; Dose-Response Relationship, Drug; Fingolimod Hydrochloride; Indoles; Lysophospholipids; Mice; Mice, Inbred C57BL; Phosphotransferases (Alcohol Group Acceptor); Polymerase Chain Reaction; Propylene Glycols; Pulmonary Alveoli; Pulmonary Emphysema; Pyrroles; Receptors, Lysosphingolipid; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Sphingosine	2010
Vascular endothelial growth factor is involved in mediating increased de novo hippocampal neurogenesis in response to traumatic brain injury. Journal of neurotrauma, 2010, Volume: 27, Issue:3 Topics: Animals; Biomarkers; Brain Injuries; Bromodeoxyuridine; Cell Death; Cell Proliferation; Disease Models, Animal; Doublecortin Domain Proteins; Hippocampus; In Situ Nick-End Labeling; Indoles; Infusion Pumps, Implantable; Male; Microtubule-Associated Proteins; Nerve Regeneration; Neurogenesis; Neuropeptides; Protein Kinase Inhibitors; Pyrroles; Rats; Rats, Sprague-Dawley; Recovery of Function; Stem Cells; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2	2010
CREB activation mediates VEGF-A's protection of neurons and cerebral vascular endothelial cells. Journal of neurochemistry, 2010, Volume: 113, Issue:1 Topics: Animals; Animals, Newborn; Brain Injuries; Cell Survival; Cells, Cultured; Chromones; CREB-Binding Protein; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Glial Fibrillary Acidic Protein; Glucose; Hypoxia; Hypoxia-Ischemia, Brain; Indoles; Injections, Intraventricular; Male; Morpholines; Neurons; Phosphorylation; Placenta Growth Factor; Platelet Endothelial Cell Adhesion Molecule-1; Pregnancy Proteins; Pyrroles; Rats; Rats, Sprague-Dawley; Serine; Signal Transduction; Time Factors; Transfection; Up-Regulation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2	2010
Vascular endothelial growth factor receptor-2 inhibition promotes cell death and limits endothelial cell proliferation in a neonatal rodent model of stroke. Stroke, 2010, Volume: 41, Issue:2 Topics: Angiogenesis Inhibitors; Animals; Animals, Newborn; Apoptosis; Calpain; Caspase 3; Cell Proliferation; Cerebral Arteries; Disease Models, Animal; Endothelial Cells; Indoles; Infarction, Middle Cerebral Artery; Magnetic Resonance Imaging; Necrosis; Neovascularization, Physiologic; Pyrroles; Rats; Rats, Sprague-Dawley; Stroke; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2	2010
Suppression of hypoxia-induced HIF-1alpha accumulation by VEGFR inhibitors: Different profiles of AAL993 versus SU5416 and KRN633. Cancer letters, 2010, Oct-01, Volume: 296, Issue:1 Topics: Angiogenesis Inhibitors; Cell Culture Techniques; Cell Line, Tumor; Colorectal Neoplasms; DNA Primers; DNA-Directed DNA Polymerase; Female; Glyceraldehyde-3-Phosphate Dehydrogenases; HeLa Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoblotting; Indoles; Phenylurea Compounds; Pyrroles; Quinazolines; Receptors, Vascular Endothelial Growth Factor; Reverse Transcriptase Polymerase Chain Reaction; RNA, Neoplasm; Vascular Endothelial Growth Factor A	2010
Synthesis and biological activity of N(4)-phenylsubstituted-6-(2,4-dichloro phenylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as vascular endothelial growth factor receptor-2 inhibitors and antiangiogenic and antitumor agents. Bioorganic & medicinal chemistry, 2010, May-15, Volume: 18, Issue:10 Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Cell Line, Tumor; Diamines; Indoles; Male; Melanoma; Mice; Mice, Nude; Molecular Structure; Phosphorylation; Pyrimidines; Pyrimidinones; Pyrroles; Structure-Activity Relationship; Vascular Endothelial Growth Factor Receptor-2	2010
Control of leucocyte differentiation from embryonic stem cells upon vasculogenesis and confrontation with tumour tissue. Journal of cellular and molecular medicine, 2010, Volume: 14, Issue:1-2 Topics: Angiogenesis Inhibitors; Animals; Antigens, CD; Biomarkers; Cell Differentiation; Cell Line; Embryonic Stem Cells; Indoles; Leukocytes; Lipopolysaccharides; Macrophage Colony-Stimulating Factor; Macrophages; Male; Mice; Monocytes; Neoplasms; Neovascularization, Physiologic; Pyrroles	2010
Adrenergic receptor blockade reverses right heart remodeling and dysfunction in pulmonary hypertensive rats. American journal of respiratory and critical care medicine, 2010, Sep-01, Volume: 182, Issue:5 Topics: Adrenergic Antagonists; Animals; Carbazoles; Carvedilol; Disease Models, Animal; Hypertension, Pulmonary; Indoles; Male; Propanolamines; Pulmonary Circulation; Pyrroles; Rats; Rats, Sprague-Dawley; Vascular Endothelial Growth Factor A; Ventricular Dysfunction, Right; Ventricular Remodeling	2010
Effect of VEGF and its receptor antagonist SU-5416, an inhibitor of angiogenesis, on processing of the β-amyloid precursor protein in primary neuronal cells derived from brain tissue of Tg2576 mice. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2010, Volume: 28, Issue:7 Topics: Amyloid beta-Protein Precursor; Angiogenesis Inhibitors; Animals; Brain; Cells, Cultured; Female; Humans; Indoles; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurons; Pyrroles; Receptors, Vascular Endothelial Growth Factor; Vascular Endothelial Growth Factor A	2010
Anti-vascular endothelial growth factor treatment in combination with chemotherapy delays hematopoietic recovery due to decreased proliferation of bone marrow hematopoietic progenitor cells. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2010, Volume: 5, Issue:9 Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Combined Chemotherapy Protocols; Blotting, Western; Bone Marrow; Cell Cycle; Cell Proliferation; Female; Flow Cytometry; Fluorouracil; Hematopoietic Stem Cells; Hematopoietic System; Indoles; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Pyrroles; Signal Transduction; Survival Rate; Treatment Outcome; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2	2010
Angiogenesis but not neurogenesis is critical for normal learning and memory acquisition. Neuroscience, 2010, Nov-24, Volume: 171, Issue:1 Topics: Analysis of Variance; Angiogenesis Inhibitors; Animals; Behavior, Animal; Bromodeoxyuridine; Cell Count; Dose-Response Relationship, Drug; Gene Expression Regulation; Hippocampus; Indoles; Male; Maze Learning; Memory; Neovascularization, Physiologic; Neurogenesis; Phosphopyruvate Hydratase; Physical Conditioning, Animal; Psychomotor Performance; Pyrroles; Rats; Rats, Long-Evans; Reaction Time; Receptor, Endothelin A; Time Factors; Zidovudine	2010
Enhanced angiogenic capacity of human umbilical vein endothelial cells from women with preeclampsia. Reproductive sciences (Thousand Oaks, Calif.), 2011, Volume: 18, Issue:4 Topics: Adult; Analysis of Variance; Angiogenesis Inhibitors; Case-Control Studies; Cell Hypoxia; Cells, Cultured; Endothelial Cells; Female; Humans; Indoles; Neovascularization, Pathologic; Neovascularization, Physiologic; Pre-Eclampsia; Pregnancy; Protein Kinase Inhibitors; Pyrroles; Receptors, Vascular Endothelial Growth Factor; Umbilical Veins; Young Adult	2011
SU5416 induces premature senescence in endothelial progenitor cells from patients with age-related macular degeneration. Molecular vision, 2011, Jan-10, Volume: 17 Topics: Apoptosis; Cellular Senescence; Endothelial Cells; Humans; Indoles; Macular Degeneration; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Protein Kinase Inhibitors; Pyrroles; Receptors, CXCR4; Signal Transduction; Stem Cells; Treatment Outcome; Umbilical Veins; Vascular Endothelial Growth Factor Receptor-2	2011
Androgen stimulates endothelial cell proliferation via an androgen receptor/VEGF/cyclin A-mediated mechanism. American journal of physiology. Heart and circulatory physiology, 2011, Volume: 300, Issue:4 Topics: Androgen Receptor Antagonists; Anilides; Aorta; Cell Proliferation; Cells, Cultured; Cyclin A; Dihydrotestosterone; DNA; Endothelium, Vascular; Estradiol; Gene Expression; Humans; Indoles; Male; Nitriles; Protein Kinase Inhibitors; Purines; Pyrroles; Receptors, Androgen; Roscovitine; Testosterone; Tosyl Compounds; Vascular Endothelial Growth Factor A	2011
Suppression of choroidal neovascularization by intravitreal injection of liposomal SU5416. Archives of ophthalmology (Chicago, Ill. : 1960), 2011, Volume: 129, Issue:3 Topics: Angiogenesis Inhibitors; Animals; Carbocyanines; Choroidal Neovascularization; Dextrans; Disease Models, Animal; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Indoles; Intravitreal Injections; Liposomes; Male; Oligopeptides; Protein-Tyrosine Kinases; Pyrroles; Rats; Rats, Inbred BN	2011
SU5416 and EGCG work synergistically and inhibit angiogenic and survival factors and induce cell cycle arrest to promote apoptosis in human malignant neuroblastoma SH-SY5Y and SK-N-BE2 cells. Neurochemical research, 2011, Volume: 36, Issue:8 Topics: Angiogenesis Inhibitors; Anticarcinogenic Agents; Apoptosis; Catechin; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Survival; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; E2F1 Transcription Factor; Humans; In Situ Nick-End Labeling; Indoles; Neovascularization, Pathologic; Neuroblastoma; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Retinoblastoma Protein; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2	2011
Angiogenic growth factors are new and essential players in the sustained relaxin vasodilatory pathway in rodents and humans. Hypertension (Dallas, Tex. : 1979), 2011, Volume: 57, Issue:6 Topics: Angiogenesis Inhibitors; Animals; Arteries; Dipeptides; Endothelin B Receptor Antagonists; Female; Humans; In Vitro Techniques; Indoles; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Mice; Mice, Inbred C57BL; Nitric Oxide Synthase; omega-N-Methylarginine; Peptides, Cyclic; Pregnancy; Pyrroles; Rats; Rats, Long-Evans; Receptor, Endothelin B; Receptors, Vascular Endothelial Growth Factor; Recombinant Proteins; Relaxin; Signal Transduction; Vasodilation	2011
Peptide-directed highly selective targeting of pulmonary arterial hypertension. The American journal of pathology, 2011, Volume: 178, Issue:6 Topics: Amino Acid Sequence; Animals; Drug Delivery Systems; Humans; Hypertension, Pulmonary; Hypoxia; Indoles; Lung; Male; Molecular Sequence Data; Monocrotaline; Peptides; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Vascular Endothelial Growth Factor; Time Factors	2011
Inhibitory effects of SU5416, a selective vascular endothelial growth factor receptor tyrosine kinase inhibitor, on experimental corneal neovascularization. Ophthalmic research, 2012, Volume: 47, Issue:1 Topics: Angiogenesis Inhibitors; Animals; Cautery; Corneal Neovascularization; Disease Models, Animal; Indoles; Injections, Intraperitoneal; Male; Mice; Mice, Inbred BALB C; Pyrroles; Silver Nitrate; Vascular Endothelial Growth Factor Receptor-2	2012
A novel xenograft model in zebrafish for high-resolution investigating dynamics of neovascularization in tumors. PloS one, 2011, Volume: 6, Issue:7 Topics: Animals; Cell Line, Tumor; Cell Proliferation; Endothelial Cells; Humans; Indoles; Mice; Microvessels; Neoplasms; Neovascularization, Pathologic; Pyrroles; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2; Xenograft Model Antitumor Assays; Zebrafish	2011
Semaphorin-PlexinD1 signaling limits angiogenic potential via the VEGF decoy receptor sFlt1. Developmental cell, 2011, Aug-16, Volume: 21, Issue:2 Topics: Angiogenesis Inhibitors; Animals; Animals, Genetically Modified; Aorta; Cell Movement; Cell Transplantation; Embryo, Nonmammalian; Endothelial Cells; Endothelium; Gene Expression Regulation, Developmental; In Vitro Techniques; Indoles; Luminescent Proteins; Molecular Sequence Data; Neovascularization, Physiologic; Oligodeoxyribonucleotides, Antisense; Pyrroles; Quinoxalines; Receptors, Cell Surface; Receptors, Notch; RNA, Messenger; Semaphorins; Signal Transduction; Thiazolidinediones; Vascular Endothelial Growth Factor Receptor-1; Zebrafish; Zebrafish Proteins	2011
Environmental enrichment has antidepressant-like action without improving learning and memory deficits in olfactory bulbectomized rats. Neuropharmacology, 2012, Volume: 62, Issue:1 Topics: Analysis of Variance; Animals; Avoidance Learning; Body Weight; Brain-Derived Neurotrophic Factor; Depression; Disease Models, Animal; Environment; Exercise Therapy; Exploratory Behavior; Indoles; Learning Disabilities; Locomotion; Maze Learning; Memory Disorders; Olfactory Bulb; Protein Kinase Inhibitors; Pyrroles; Rats; Rats, Sprague-Dawley; Recognition, Psychology; RNA, Messenger; Time Factors; Vascular Endothelial Growth Factor A	2012
C-type natriuretic peptide does not attenuate the development of pulmonary hypertension caused by hypoxia and VEGF receptor blockade. Life sciences, 2011, Sep-26, Volume: 89, Issue:13-14 Topics: Animals; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Indoles; Lung; Male; Natriuretic Agents; Natriuretic Peptide, C-Type; Protein Kinase Inhibitors; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Vascular Endothelial Growth Factor	2011
A novel murine model of severe pulmonary arterial hypertension. American journal of respiratory and critical care medicine, 2011, Nov-15, Volume: 184, Issue:10 Topics: Acute Disease; Animals; Blotting, Western; Cytokines; Disease Models, Animal; Echocardiography; Female; Fluorescent Antibody Technique; Gene Expression Profiling; Hemodynamics; Hypertension, Pulmonary; Hypoxia; Indoles; Lung; Male; Mice; Mice, Inbred C57BL; Pyrroles; Receptors, Vascular Endothelial Growth Factor	2011
[The effects of VEGF-R inhibitor on podocytopathy of rats with type I diabetic nephropathy]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 2011, Volume: 27, Issue:9 Topics: Albuminuria; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Gene Expression Regulation; Indoles; Intracellular Signaling Peptides and Proteins; Male; Membrane Proteins; Podocytes; Protein Kinase Inhibitors; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Vascular Endothelial Growth Factor; RNA, Messenger; Vascular Endothelial Growth Factor A	2011
VEGF regulates antidepressant effects of lamotrigine. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2012, Volume: 22, Issue:6 Topics: Analysis of Variance; Animals; Antidepressive Agents; Disease Models, Animal; Down-Regulation; Enzyme-Linked Immunosorbent Assay; Exploratory Behavior; Food Preferences; Frontal Lobe; Hippocampus; Indoles; Lamotrigine; Male; Protein Kinase Inhibitors; Pyrroles; Rats; Rats, Sprague-Dawley; Stress, Psychological; Sucrose; Sweetening Agents; Triazines; Vascular Endothelial Growth Factor A	2012
Study of differences in the VEGFR2 inhibitory activities between semaxanib and SU5205 using 3D-QSAR, docking, and molecular dynamics simulations. Journal of molecular graphics & modelling, 2012, Volume: 32 Topics: Binding Sites; Catalytic Domain; Computer Simulation; Humans; Indoles; Models, Molecular; Molecular Dynamics Simulation; Pyrroles; Quantitative Structure-Activity Relationship; Structure-Activity Relationship; Vascular Endothelial Growth Factor Receptor-2	2012
Copper dependence of angioproliferation in pulmonary arterial hypertension in rats and humans. American journal of respiratory cell and molecular biology, 2012, Volume: 46, Issue:5 Topics: Animals; Caspases; Cell Division; Cells, Cultured; Chelating Agents; Copper; Diet; Endothelium, Vascular; Enzyme Activation; Humans; Hypertension, Pulmonary; Hypoxia; Immunohistochemistry; Indoles; Male; Microvessels; Molybdenum; Neovascularization, Pathologic; Pyrroles; Rats; Rats, Sprague-Dawley	2012
Pro-angiogenic activity of astragaloside IV in HUVECs in vitro and zebrafish in vivo. Molecular medicine reports, 2012, Volume: 5, Issue:3 Topics: Angiogenesis Inducing Agents; Animals; Astragalus Plant; Astragalus propinquus; Cell Movement; Cell Proliferation; Cells, Cultured; Drugs, Chinese Herbal; Gene Expression Regulation; Human Umbilical Vein Endothelial Cells; Humans; Indoles; Neovascularization, Physiologic; Phosphatidylinositols; Proto-Oncogene Proteins c-akt; Pyrroles; Receptors, Vascular Endothelial Growth Factor; Saponins; Triterpenes; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2; Zebrafish	2012
Vascular endothelial growth factor enhances macrophage clearance of apoptotic cells. American journal of physiology. Lung cellular and molecular physiology, 2012, Apr-01, Volume: 302, Issue:7 Topics: Animals; Antibodies, Monoclonal; Apoptosis; Cell Line; Doxycycline; Emphysema; Humans; Indoles; Jurkat Cells; Lung; Macrophages, Alveolar; Mice; Mice, Inbred C57BL; Mice, Transgenic; Pyrroles; rac1 GTP-Binding Protein; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1	2012
Normalization of the lymph node T cell stromal microenvironment in lpr/lpr mice is associated with SU5416-induced reduction in autoantibodies. PloS one, 2012, Volume: 7, Issue:3 Topics: Animals; Antibodies, Antinuclear; Autoantibodies; B-Lymphocytes; Cellular Microenvironment; Disease Models, Animal; Immunophenotyping; Indoles; Lupus Erythematosus, Systemic; Lymph Nodes; Mice; Mice, Inbred MRL lpr; Pyrroles; Receptors, Vascular Endothelial Growth Factor; T-Lymphocytes	2012
HIF1A induces expression of the WASF3 metastasis-associated gene under hypoxic conditions. International journal of cancer, 2012, Sep-15, Volume: 131, Issue:6 Topics: Breast Neoplasms; Cell Hypoxia; Female; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indoles; Neoplasm Metastasis; Pyrroles; Transcription, Genetic; Tumor Microenvironment; Vascular Endothelial Growth Factor A; Wiskott-Aldrich Syndrome Protein Family	2012
c-Jun N-terminal kinase mediated VEGFR2 sustained phosphorylation is critical for VEGFA-induced angiogenesis in vitro and in vivo. Cell biochemistry and biophysics, 2012, Volume: 64, Issue:1 Topics: Animals; Anthracenes; Cell Movement; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Activation; Human Umbilical Vein Endothelial Cells; Humans; Indoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Neovascularization, Physiologic; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyrroles; Recombinant Proteins; RNA, Small Interfering; Transfection; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2	2012
Leptin induces tube formation in first-trimester extravillous trophoblast cells. European journal of obstetrics, gynecology, and reproductive biology, 2012, Volume: 164, Issue:1 Topics: Angiogenesis Inhibitors; Angiopoietin-Like Protein 4; Angiopoietins; Cell Line; Docosahexaenoic Acids; Endothelial Cells; Fatty Acid-Binding Proteins; Female; Humans; Indoles; Leptin; Lipid Metabolism; Neovascularization, Physiologic; Pregnancy; Pregnancy Trimester, First; Pyrroles; Trophoblasts	2012
Systemic anti-vascular endothelial growth factor therapies induce a painful sensory neuropathy. Brain : a journal of neurology, 2012, Volume: 135, Issue:Pt 9 Topics: Animals; Antibodies, Neutralizing; Behavior, Animal; Ganglia, Spinal; Indoles; Mice; Mice, Transgenic; Neuralgia; Neurons; Paclitaxel; Pain Measurement; Polyneuropathies; Protein Kinase Inhibitors; Pyrroles; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2	2012
Severe pulmonary arterial hypertension induced by SU5416 and ovalbumin immunization. American journal of respiratory cell and molecular biology, 2012, Volume: 47, Issue:5 Topics: Animals; Antilymphocyte Serum; Apoptosis; Asparagine; B-Lymphocytes; Caspase Inhibitors; Cell Proliferation; Dexamethasone; Disease Models, Animal; Hemodynamics; Hypertension, Pulmonary; Hypoxia-Inducible Factor 1, alpha Subunit; Immunization; Indoles; Interleukin-6; Lung; Male; Ovalbumin; Proliferating Cell Nuclear Antigen; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Vascular Endothelial Growth Factor; Vascular Endothelial Growth Factor A	2012
The soluble guanylate cyclase stimulator riociguat ameliorates pulmonary hypertension induced by hypoxia and SU5416 in rats. PloS one, 2012, Volume: 7, Issue:8 Topics: Animals; Apoptosis; Blood Pressure; Blotting, Western; Caspase 3; Cell Proliferation; Cyclic GMP; Guanylate Cyclase; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Immunohistochemistry; Indoles; Lung; Male; Nitric Oxide Synthase Type III; Phosphodiesterase 5 Inhibitors; Piperazines; Purines; Pyrazoles; Pyrimidines; Pyrroles; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Sildenafil Citrate; Soluble Guanylyl Cyclase; Sulfones; Time Factors; Treatment Outcome	2012
CCAAT/Enhancer-binding protein-homologous protein sensitizes to SU5416 by modulating p21 and PI3K/Akt signal pathway in FRO anaplastic thyroid carcinoma cells. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2013, Volume: 45, Issue:1 Topics: Cell Line, Tumor; Cell Survival; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Down-Regulation; Drug Screening Assays, Antitumor; Gene Knockdown Techniques; Humans; Indoles; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Pyrroles; Signal Transduction; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms; Transcription Factor CHOP; Tumor Suppressor Protein p53	2013
Vitamin D improves the angiogenic properties of endothelial progenitor cells. American journal of physiology. Cell physiology, 2012, Nov-01, Volume: 303, Issue:9 Topics: Angiogenesis Inhibitors; Cell Proliferation; Cells, Cultured; Cholecalciferol; Endothelial Cells; Female; Fetal Blood; Flow Cytometry; Humans; Immunohistochemistry; Indoles; Matrix Metalloproteinase 2; Neovascularization, Physiologic; Pre-Eclampsia; Pregnancy; Pyridoxal Phosphate; Pyrroles; Receptors, Calcitriol; Risk; Signal Transduction; Stem Cells; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1	2012
SU5416, a VEGF receptor inhibitor and ligand of the AHR, represents a new alternative for immunomodulation. PloS one, 2012, Volume: 7, Issue:9 Topics: Adjuvants, Immunologic; Animals; Aryl Hydrocarbon Hydroxylases; CD4-Positive T-Lymphocytes; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1B1; Enzyme Induction; Forkhead Transcription Factors; Indoleamine-Pyrrole 2,3,-Dioxygenase; Indoles; Ligands; Mice; Point Mutation; Pyrroles; Receptors, Aryl Hydrocarbon; Receptors, Vascular Endothelial Growth Factor; Repressor Proteins; Spleen; Transcription, Genetic; Up-Regulation	2012
Unexpected neuronal protection of SU5416 against 1-Methyl-4-phenylpyridinium ion-induced toxicity via inhibiting neuronal nitric oxide synthase. PloS one, 2012, Volume: 7, Issue:9 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Blotting, Western; Cells, Cultured; Indoles; Neurons; Nitric Oxide Synthase Type I; PC12 Cells; Pyrroles; Rats; Rats, Sprague-Dawley; Zebrafish	2012
Sodium nitrite therapy rescues ischemia-induced neovascularization and blood flow recovery in hypertension. Pflugers Archiv : European journal of physiology, 2012, Volume: 464, Issue:6 Topics: Allopurinol; Angiotensin II; Animals; Arterial Pressure; Capillaries; Cyclic AMP; Cyclic GMP; Femoral Artery; Hindlimb; Hypertension; Indoles; Ischemia; Male; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Neovascularization, Pathologic; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Proto-Oncogene Proteins c-akt; Pyrroles; Receptors, Vascular Endothelial Growth Factor; Regional Blood Flow; Sodium Nitrite; Xanthine Dehydrogenase	2012
BDNF/TrkB signaling augments smooth muscle cell proliferation in pulmonary hypertension. The American journal of pathology, 2012, Volume: 181, Issue:6 Topics: Animals; Brain-Derived Neurotrophic Factor; Cell Hypoxia; Cell Proliferation; Disease Models, Animal; DNA; Early Growth Response Protein 1; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Humans; Hypertension, Pulmonary; Indoles; Ligands; Lung; Male; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Monocrotaline; Myocytes, Smooth Muscle; Protein Binding; Pyrroles; Rats; Receptor, trkB; Signal Transduction	2012
Imatinib attenuates hypoxia-induced pulmonary arterial hypertension pathology via reduction in 5-hydroxytryptamine through inhibition of tryptophan hydroxylase 1 expression. American journal of respiratory and critical care medicine, 2013, Jan-01, Volume: 187, Issue:1 Topics: Animals; Benzamides; Disease Models, Animal; Hemodynamics; Hypertension, Pulmonary; Hypoxia; Imatinib Mesylate; Indoles; Mice; Mice, Knockout; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrimidines; Pyrroles; Receptor, Platelet-Derived Growth Factor beta; Serotonin; Tryptophan Hydroxylase	2013
Deeper penetration into tumor tissues and enhanced in vivo antitumor activity of liposomal paclitaxel by pretreatment with angiogenesis inhibitor SU5416. Molecular pharmaceutics, 2012, Dec-03, Volume: 9, Issue:12 Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents, Phytogenic; Colonic Neoplasms; Humans; Immunoenzyme Techniques; Indoles; Liposomes; Male; Mice; Mice, Inbred BALB C; Neovascularization, Pathologic; Paclitaxel; Pericytes; Polyethylene Glycols; Pyrroles; Solubility; Tumor Cells, Cultured; Vascular Endothelial Growth Factor Receptor-2	2012
The evolutionary origins of chordate hematopoiesis and vertebrate endothelia. Developmental biology, 2013, Mar-15, Volume: 375, Issue:2 Topics: Animals; Biological Evolution; Biomarkers; Body Patterning; Cardiovascular System; Embryo, Nonmammalian; Endothelium; Gene Expression Regulation, Developmental; Hematopoiesis; Indoles; Larva; Models, Biological; Phylogeny; Pyrroles; Receptors, Platelet-Derived Growth Factor; Receptors, Vascular Endothelial Growth Factor; Tretinoin; Vertebrates	2013
Suppression of DHT-induced paracrine stimulation of endothelial cell growth by estrogens via prostate cancer cells. The Prostate, 2013, Volume: 73, Issue:10 Topics: Androgens; Animals; Cell Line; Cell Line, Tumor; Cell Size; Dihydrotestosterone; Endothelial Cells; Estradiol; Estrogens; Humans; Indoles; Male; Mice; Prostate; Prostatic Neoplasms; Pyrroles; Receptors, Vascular Endothelial Growth Factor	2013
Activation of lung p53 by Nutlin-3a prevents and reverses experimental pulmonary hypertension. Circulation, 2013, Apr-23, Volume: 127, Issue:16 Topics: Animals; Apoptosis; Cells, Cultured; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p21; Drug Evaluation, Preclinical; Endothelial Cells; Gene Expression Regulation; Genes, p53; Humans; Hypertension, Pulmonary; Hypoxia; Imidazoles; Indoles; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Phosphorylation; Piperazines; Protein Processing, Post-Translational; Protein Stability; Pulmonary Artery; Pyrroles; Serotonin Plasma Membrane Transport Proteins; Single-Blind Method; Tumor Suppressor Protein p53; Ultrasonography	2013
Critical role for the advanced glycation end-products receptor in pulmonary arterial hypertension etiology. Journal of the American Heart Association, 2013, Jan-16, Volume: 2, Issue:1 Topics: Adult; Aged; Animals; Apoptosis; Arterial Pressure; Bone Morphogenetic Protein Receptors, Type II; Case-Control Studies; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Female; Glycation End Products, Advanced; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Indoles; Male; Middle Aged; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; PPAR gamma; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; Receptor for Advanced Glycation End Products; Receptors, Immunologic; RNA Interference; S100 Proteins; Signal Transduction; STAT3 Transcription Factor; Transfection; Up-Regulation	2013
Coculture with endothelial cells enhances osteogenic differentiation of periodontal ligament stem cells via cyclooxygenase-2/prostaglandin E2/vascular endothelial growth factor signaling under hypoxia. Journal of periodontology, 2013, Volume: 84, Issue:12 Topics: Angiogenesis Inhibitors; Cell Culture Techniques; Cell Differentiation; Cell Hypoxia; Coculture Techniques; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Endothelial Cells; Flavonoids; Human Umbilical Vein Endothelial Cells; Humans; Indoles; Nitrobenzenes; Osteogenesis; Periodontal Ligament; Prostaglandin Antagonists; Protein Kinase Inhibitors; Pyrroles; Signal Transduction; Stem Cells; Sulfonamides; Thiophenes; Triazoles; Vascular Endothelial Growth Factor A; Xanthones	2013
Biomimetic model to reconstitute angiogenic sprouting morphogenesis in vitro. Proceedings of the National Academy of Sciences of the United States of America, 2013, Apr-23, Volume: 110, Issue:17 Topics: Biomimetics; Cell Polarity; Dimethylpolysiloxanes; Fingolimod Hydrochloride; Fluorescent Antibody Technique; Human Umbilical Vein Endothelial Cells; Humans; Indoles; Lysophospholipids; Microfluidics; Models, Biological; Morphogenesis; Neovascularization, Physiologic; Propylene Glycols; Pseudopodia; Pyrroles; Sphingosine; Vascular Endothelial Growth Factor Receptor-2	2013
Dehydroepiandrosterone restores right ventricular structure and function in rats with severe pulmonary arterial hypertension. American journal of physiology. Heart and circulatory physiology, 2013, Jun-15, Volume: 304, Issue:12 Topics: Animals; Apoptosis; Blood Pressure; Dehydroepiandrosterone; Fibrosis; Gene Expression; Heart Ventricles; Hypertension, Pulmonary; Hypoxia; Indoles; Male; NADP; NFATC Transcription Factors; Oxidative Stress; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; STAT3 Transcription Factor; Ventricular Dysfunction	2013
Influence of soluble or matrix-bound isoforms of vascular endothelial growth factor-A on tumor response to vascular-targeted strategies. International journal of cancer, 2013, Dec-01, Volume: 133, Issue:11 Topics: Animals; Fibrosarcoma; Gene Expression Regulation, Neoplastic; Humans; Indoles; Mice; Neovascularization, Pathologic; Protein Isoforms; Pyrroles; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2	2013
Neuropilin-1 modulates vascular endothelial growth factor-induced poly(ADP-ribose)-polymerase leading to reduced cerebrovascular apoptosis. Neurobiology of disease, 2013, Volume: 59 Topics: Animals; Apoptosis; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelial Cells; Gene Expression Regulation; Humans; Indoles; Infarction, Middle Cerebral Artery; Male; Neurons; Neuropilin-1; Poly(ADP-ribose) Polymerases; Protein Kinase Inhibitors; Pyrroles; Rats; Rats, Wistar; Signal Transduction; Time Factors; Umbilical Veins; Vascular Endothelial Growth Factor A	2013
Endothelial injury in a transforming growth factor β-dependent mouse model of scleroderma induces pulmonary arterial hypertension. Arthritis and rheumatism, 2013, Volume: 65, Issue:11 Topics: Angiogenesis Inhibitors; Animals; Disease Models, Animal; Endothelium, Vascular; Familial Primary Pulmonary Hypertension; Female; Hypertension, Pulmonary; Hypoxia; Indoles; Lac Operon; Male; Mice; Mice, Transgenic; Phenotype; Protein Serine-Threonine Kinases; Pulmonary Circulation; Pyrroles; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Receptors, Vascular Endothelial Growth Factor; Scleroderma, Systemic; Signal Transduction; Transforming Growth Factor beta	2013
VEGF promotes cardiac stem cells differentiation into vascular endothelial cells via the PI3K/Akt signaling pathway. Artificial cells, nanomedicine, and biotechnology, 2014, Volume: 42, Issue:6 Topics: Adult Stem Cells; Animals; Cell Differentiation; Cells, Cultured; Endothelium, Vascular; Indoles; Myoblasts, Cardiac; Myocardium; Oncogene Protein v-akt; Phenotype; Phosphatidylinositol 3-Kinases; Pyrroles; Rats; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Stem Cell Transplantation; Vascular Endothelial Growth Factor A; Wound Healing	2014
Vascular endothelial growth factor receptor inhibitor SU5416 suppresses lymphocyte generation and immune responses in mice by increasing plasma corticosterone. PloS one, 2013, Volume: 8, Issue:9 Topics: Animals; Corticosterone; Immunity, Active; Indoles; Lymphocytes; Mice; Mice, Inbred C57BL; Pyrroles; Receptors, Vascular Endothelial Growth Factor; Transforming Growth Factor beta	2013
TRPC4 inactivation confers a survival benefit in severe pulmonary arterial hypertension. The American journal of pathology, 2013, Volume: 183, Issue:6 Topics: Angiogenesis Inhibitors; Animals; Animals, Genetically Modified; Cardiac Output; Disease Models, Animal; Hypertension, Pulmonary; Indoles; Male; Pulmonary Artery; Pyrroles; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Time Factors; TRPC Cation Channels	2013
Treatment with anti-gremlin 1 antibody ameliorates chronic hypoxia/SU5416-induced pulmonary arterial hypertension in mice. The American journal of pathology, 2013, Volume: 183, Issue:5 Topics: Animals; Antibodies, Monoclonal; Bone Morphogenetic Proteins; Chronic Disease; Familial Primary Pulmonary Hypertension; Heart Ventricles; HEK293 Cells; Hemodynamics; Humans; Hypertension, Pulmonary; Hypoxia; Indoles; Intercellular Signaling Peptides and Proteins; Lung; Mice; Pyrroles; Signal Transduction	2013
Interferon alpha and rapamycin inhibit the growth of pheochromocytoma PC12 line in vitro. Endokrynologia Polska, 2013, Volume: 64, Issue:5 Topics: Adrenal Gland Neoplasms; Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Cell Proliferation; Endostatins; Growth Hormone-Releasing Hormone; Indoles; Interferon-alpha; Neovascularization, Pathologic; PC12 Cells; Pheochromocytoma; Pyrroles; Rats; Sirolimus; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A	2013
Changes in large pulmonary arterial viscoelasticity in chronic pulmonary hypertension. PloS one, 2013, Volume: 8, Issue:11 Topics: Angiogenesis Inhibitors; Animals; Blood Pressure; Chronic Disease; Collagen; Elastic Modulus; Familial Primary Pulmonary Hypertension; Hypertension, Pulmonary; Hypoxia; Indoles; Male; Mice; Mice, Inbred C57BL; Myocytes, Smooth Muscle; Proteoglycans; Pyrroles; Stress, Mechanical; Vascular Stiffness; Ventricular Dysfunction, Right; Viscosity	2013
Temporal hemodynamic and histological progression in Sugen5416/hypoxia/normoxia-exposed pulmonary arterial hypertensive rats. American journal of physiology. Heart and circulatory physiology, 2014, Jan-15, Volume: 306, Issue:2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiogenesis Inhibitors; Animals; Familial Primary Pulmonary Hypertension; Hemodynamics; Hypertension, Pulmonary; Hypoxia; Indoles; Male; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; Vasodilator Agents	2014
Inhibition of vascular endothelial growth factor receptor under hypoxia causes severe, human-like pulmonary arterial hypertension in mice: potential roles of interleukin-6 and endothelin. Life sciences, 2014, Nov-24, Volume: 118, Issue:2 Topics: Animals; Biomarkers; Body Weight; Cell Hypoxia; Cell Line; Disease Models, Animal; Endothelial Cells; Endothelin-1; Heart Rate; Humans; Hypertension, Pulmonary; Indoles; Inflammation; Interleukin-6; Lung; Male; Mice; Pulmonary Artery; Pyrroles; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Up-Regulation	2014
CXCR4 inhibition ameliorates severe obliterative pulmonary hypertension and accumulation of C-kit⁺ cells in rats. PloS one, 2014, Volume: 9, Issue:2 Topics: Actins; Analysis of Variance; Animals; Arterial Occlusive Diseases; Benzylamines; Cyclams; Fluorescent Antibody Technique; Heterocyclic Compounds; Hypertension, Pulmonary; Immunohistochemistry; In Situ Hybridization; Indoles; Microscopy, Confocal; Proto-Oncogene Proteins c-kit; Pyrroles; Rats; Receptors, CXCR4; von Willebrand Factor	2014
Effects of vascular endothelial growth factor on endothelin-1 production by human lung microvascular endothelial cells in vitro. Life sciences, 2014, Nov-24, Volume: 118, Issue:2 Topics: Blotting, Western; Endothelial Cells; Endothelin-1; Growth Differentiation Factor 2; Humans; Indoles; Lung; Microvessels; Phosphorylation; Pyrroles; Receptors, Vascular Endothelial Growth Factor; Vascular Endothelial Growth Factor A	2014
Identification and characterization of VEGF and FGF from Hydra. The International journal of developmental biology, 2013, Volume: 57, Issue:11-12 Topics: Amino Acid Sequence; Animals; Cell Lineage; Ectoderm; Endoderm; Fibroblast Growth Factors; Gene Expression Profiling; Gene Expression Regulation, Developmental; Hydra; In Situ Hybridization; Indoles; Molecular Conformation; Molecular Sequence Data; Phylogeny; Pyrroles; Sequence Homology, Amino Acid; Signal Transduction; Vascular Endothelial Growth Factor A	2013
Nuclear factor κB inhibition reduces lung vascular lumen obliteration in severe pulmonary hypertension in rats. American journal of respiratory cell and molecular biology, 2014, Volume: 51, Issue:3 Topics: Animals; Apoptosis; CD4-Positive T-Lymphocytes; Familial Primary Pulmonary Hypertension; Humans; Hypertension, Pulmonary; Hypoxia; Indoles; Inflammation; Interleukin-6; Leukocyte Common Antigens; Lung; NF-kappa B; Pulmonary Artery; Pyrroles; Pyrrolidines; Rats; Signal Transduction; Thiocarbamates; Time Factors	2014
NPY/Y₁ receptor-mediated vasoconstrictory and proliferative effects in pulmonary hypertension. British journal of pharmacology, 2014, Volume: 171, Issue:16 Topics: Adult; Animals; Arginine; Cell Proliferation; Epinephrine; Female; Humans; Hypertension, Pulmonary; Hypoxia; In Vitro Techniques; Indoles; Lung; Male; Mice, Inbred C57BL; Monocrotaline; Myocytes, Smooth Muscle; Neuropeptide Y; Pulmonary Artery; Pyrroles; Rats, Sprague-Dawley; Receptors, Neuropeptide Y; Vasoconstriction; Vasoconstrictor Agents; Young Adult	2014
SuHx rat model: partly reversible pulmonary hypertension and progressive intima obstruction. The European respiratory journal, 2014, Volume: 44, Issue:1 Topics: Angiogenesis Inhibitors; Animals; Circadian Rhythm; Disease Models, Animal; Disease Progression; Echocardiography; Heart Ventricles; Hemodynamics; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Indoles; Lung; Male; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; Systole; Telemetry; Tunica Intima; Vascular Remodeling	2014
Effects of the vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitor SU5416 on in vitro cultures of Plasmodium falciparum. Malaria journal, 2014, May-28, Volume: 13 Topics: Animals; Antimalarials; Cytosol; Disease Models, Animal; Erythrocytes; Female; Flow Cytometry; Humans; Immunohistochemistry; Indoles; Malaria; Mice, Inbred C57BL; Plasmodium berghei; Plasmodium falciparum; Pyrroles; Tyrosine; Vascular Endothelial Growth Factor Receptor-2	2014
Vitamin D antagonizes negative effects of preeclampsia on fetal endothelial colony forming cell number and function. PloS one, 2014, Volume: 9, Issue:6 Topics: Adult; Calcitriol; Case-Control Studies; Cell Movement; Cell Proliferation; Cells, Cultured; Endothelial Cells; Female; Fetal Blood; Humans; Indoles; Microtubules; Pre-Eclampsia; Pregnancy; Pyrroles; Receptors, Calcitriol; RNA Interference; RNA, Small Interfering; Signal Transduction; Vascular Endothelial Growth Factor A	2014
Direct and indirect protection of right ventricular function by estrogen in an experimental model of pulmonary arterial hypertension. American journal of physiology. Heart and circulatory physiology, 2014, Aug-01, Volume: 307, Issue:3 Topics: Animals; Arterial Pressure; Cardiotonic Agents; Compliance; Disease Models, Animal; Drug Implants; Estradiol; Estrogen Replacement Therapy; Estrogens; Female; Heart Ventricles; Hypertension, Pulmonary; Hypoxia; Indoles; Mice, Inbred C57BL; Myocardial Contraction; Ovariectomy; Pulmonary Artery; Pyrroles; Stroke Volume; Time Factors; Vascular Remodeling; Ventricular Dysfunction, Right; Ventricular Function, Right	2014
NADPH oxidase 4 is expressed in pulmonary artery adventitia and contributes to hypertensive vascular remodeling. Arteriosclerosis, thrombosis, and vascular biology, 2014, Volume: 34, Issue:8 Topics: Adventitia; Animals; Antihypertensive Agents; Cell Movement; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Matrix; Familial Primary Pulmonary Hypertension; Fibroblasts; HEK293 Cells; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Indoles; Male; Mice; Mice, Inbred C57BL; Monocrotaline; NADPH Oxidase 4; NADPH Oxidases; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction; Time Factors; Transfection; Up-Regulation	2014
Determinants for in vivo antitumor effect of angiogenesis inhibitor SU5416 formulated in PEGylated emulsion. Journal of pharmaceutical sciences, 2014, Volume: 103, Issue:8 Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Cell Line; Cell Line, Tumor; Emulsions; Endothelium, Vascular; Humans; Indoles; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neoplasms; Neovascularization, Pathologic; Pharmaceutical Vehicles; Polyethylene Glycols; Protein Kinase Inhibitors; Pyrroles; Vascular Endothelial Growth Factor A	2014
Novel dual endothelin receptor antagonist macitentan reverses severe pulmonary arterial hypertension in rats. Journal of cardiovascular pharmacology, 2014, Volume: 64, Issue:5 Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Indoles; Male; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Sulfonamides; Time Factors; Vascular Endothelial Growth Factor A	2014
Iloprost reverses established fibrosis in experimental right ventricular failure. The European respiratory journal, 2015, Volume: 45, Issue:2 Topics: Animals; Collagen; Cyclic AMP-Dependent Protein Kinases; Echocardiography; Fibroblasts; Fibrosis; Heart Ventricles; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Iloprost; Indoles; Male; Matrix Metalloproteinase 9; Microscopy, Phase-Contrast; Physical Conditioning, Animal; Procollagen; Pyrroles; Random Allocation; Rats; Rats, Sprague-Dawley; RNA, Messenger; Transforming Growth Factor beta1; Vasodilator Agents; Ventricular Function, Right	2015
Blocking VEGF signaling delays development of replacement teeth in zebrafish. Journal of dental research, 2015, Volume: 94, Issue:1 Topics: Alkaline Phosphatase; Angiogenesis Inhibitors; Animals; Blood Vessels; Cell Differentiation; Embryo, Nonmammalian; Indoles; Larva; Neovascularization, Physiologic; Odontogenesis; Pyrroles; Tooth; Tooth Germ; Vascular Endothelial Growth Factor A; Zebrafish; Zebrafish Proteins	2015
Involvement of vascular endothelial growth factor in serotonin 1A receptor-mediated neuroproliferation in neonatal mouse hippocampus. Advances in experimental medicine and biology, 2015, Volume: 842 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Animals, Newborn; Butadienes; Cell Proliferation; Doublecortin Domain Proteins; Enzyme Inhibitors; Hippocampus; Immunohistochemistry; Indoles; Ki-67 Antigen; Mice, Inbred C57BL; Microscopy, Confocal; Microtubule-Associated Proteins; Neurons; Neuropeptides; Nitriles; Organ Culture Techniques; Piperazines; Pyridines; Pyrroles; Receptor, Serotonin, 5-HT1A; Serotonin Receptor Agonists; Signal Transduction; Vascular Endothelial Growth Factor A	2015
Human placental eXpanded (PLX) mesenchymal-like adherent stromal cells confer neuroprotection to nerve growth factor (NGF)-differentiated PC12 cells exposed to ischemia by secretion of IL-6 and VEGF. Biochimica et biophysica acta, 2015, Volume: 1853, Issue:2 Topics: Animals; Antibodies, Monoclonal; Cell Adhesion; Cell Count; Cell Death; Cell Differentiation; Cell Proliferation; Culture Media, Conditioned; Cyclic N-Oxides; Female; Humans; Indoles; Interleukin-6; Ischemia; L-Lactate Dehydrogenase; Lipid Peroxidation; Mesenchymal Stem Cells; Mice; Nerve Growth Factors; Neuroprotective Agents; PC12 Cells; Placenta; Pregnancy; Pyrroles; Rats; Spin Labels; Vascular Endothelial Growth Factor A	2015
Prostatic angiogenic responses in late life: antiangiogenic therapy influences and relation with the glandular microenvironment in the transgenic adenocarcinoma of mouse prostate (TRAMP) model. The Prostate, 2015, Apr-01, Volume: 75, Issue:5 Topics: 5-alpha Reductase Inhibitors; Adenocarcinoma; Angiogenesis Inhibitors; Animals; Blotting, Western; Cyclohexanes; Disease Models, Animal; Endostatins; Fibroblast Growth Factor 2; Finasteride; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Indoles; Male; Mice; Mice, Transgenic; Neovascularization, Pathologic; O-(Chloroacetylcarbamoyl)fumagillol; Prostatic Neoplasms; Pyrroles; Sesquiterpenes; Tumor Microenvironment; Vascular Endothelial Growth Factor A	2015
ID3 contributes to the acquisition of molecular stem cell-like signature in microvascular endothelial cells: its implication for understanding microvascular diseases. Microvascular research, 2015, Volume: 98 Topics: AC133 Antigen; Animals; Antigens, CD; Antigens, CD34; Cell Cycle; Cell Differentiation; Cell Separation; Endothelial Cells; Flow Cytometry; Glycoproteins; Humans; Indoles; Inhibitor of Differentiation Proteins; Microcirculation; Neoplasm Proteins; Peptides; Phenotype; Pyrroles; Rats; Stem Cells; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-3	2015
Delayed inhibition of VEGF signaling after stroke attenuates blood-brain barrier breakdown and improves functional recovery in a comorbidity-dependent manner. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015, Apr-01, Volume: 35, Issue:13 Topics: Animals; Blood-Brain Barrier; Brain; Capillaries; Dendritic Spines; Diabetes Mellitus, Experimental; Disease Models, Animal; Endothelial Cells; Gene Expression; Indoles; Infarction; Insulin; Mice; Permeability; Pyrroles; Recovery of Function; Signal Transduction; Stroke; Synapses; Transcytosis; Vascular Endothelial Growth Factor Receptor-2	2015
Lipid nanoparticle delivery of a microRNA-145 inhibitor improves experimental pulmonary hypertension. Journal of controlled release : official journal of the Controlled Release Society, 2015, Jul-28, Volume: 210 Topics: Animals; Hypertension, Pulmonary; Hypoxia; Indoles; Lipids; Liposomes; Lung; Male; MicroRNAs; Nanoparticles; Oligonucleotides; Pyrroles; Rats, Sprague-Dawley	2015
Blockade of vascular endothelial growth factor-A/receptor 2 exhibits a protective effect on angiotensin-II stimulated podocytes. Molecular medicine reports, 2015, Volume: 12, Issue:3 Topics: Angiotensin II; Animals; Cells, Cultured; Extracellular Signal-Regulated MAP Kinases; Indoles; Mice; Microfilament Proteins; Phosphorylation; Podocytes; Protein Processing, Post-Translational; Pyrroles; Transcriptional Activation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2	2015
Peroxisome Proliferator-Activated Receptor γ and microRNA 98 in Hypoxia-Induced Endothelin-1 Signaling. American journal of respiratory cell and molecular biology, 2016, Volume: 54, Issue:1 Topics: 3' Untranslated Regions; Animals; Binding Sites; Cell Proliferation; Cells, Cultured; Endothelial Cells; Endothelin-1; Gene Expression Regulation; Humans; Hypertension, Pulmonary; Hypoxia; Indoles; Male; Mice, Inbred C57BL; Mice, Knockout; MicroRNAs; PPAR gamma; Pulmonary Artery; Pyrroles; RNA Interference; Rosiglitazone; Signal Transduction; Thiazolidinediones; Transfection; Vascular Remodeling	2016
Severe pulmonary hypertension is associated with altered right ventricle metabolic substrate uptake. American journal of physiology. Lung cellular and molecular physiology, 2015, Sep-01, Volume: 309, Issue:5 Topics: Animals; Biological Transport; Fatty Acid Transport Proteins; Fatty Acids; Female; Glucose; Heart Ventricles; Hypertension, Pulmonary; Hypoxia; Indoles; Lipoprotein Lipase; Oxidation-Reduction; Positron-Emission Tomography; Protein Kinase Inhibitors; Pyrroles; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Receptors, Vascular Endothelial Growth Factor	2015
Marked Strain-Specific Differences in the SU5416 Rat Model of Severe Pulmonary Arterial Hypertension. American journal of respiratory cell and molecular biology, 2016, Volume: 54, Issue:4 Topics: Animals; Disease Models, Animal; Hypertension, Pulmonary; Hypoxia; Indoles; Pyrroles; Rats; Rats, Inbred F344; Rats, Inbred Lew; Rats, Sprague-Dawley; Species Specificity	2016
Mechanisms for SU5416 as a radiosensitizer of endothelial cells. International journal of oncology, 2015, Volume: 47, Issue:4 Topics: Angiogenesis Inhibitors; Apoptosis; Blotting, Western; Cell Line; Cell Movement; Cell Proliferation; Endothelial Cells; Flow Cytometry; Humans; Immunohistochemistry; Indoles; Pyrroles; Radiation-Sensitizing Agents	2015
Photoinduced Isomerization and Hepatoxicities of Semaxanib, Sunitinib and Related 3-Substituted Indolin-2-ones. ChemMedChem, 2016, Jan-05, Volume: 11, Issue:1 Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Hep G2 Cells; Humans; Indoles; Liver Neoplasms; Molecular Structure; Photochemical Processes; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrroles; Stereoisomerism; Structure-Activity Relationship; Sunitinib	2016
VEGF/VEGFR2 Signaling Regulates Germ Cell Proliferation in vitro and Promotes Mouse Testicular Regeneration in vivo. Cells, tissues, organs, 2016, Volume: 201, Issue:1 Topics: Animals; Cell Line; Cell Proliferation; DEAD-box RNA Helicases; Indoles; Male; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Mice, Nude; Platelet Endothelial Cell Adhesion Molecule-1; Pyrroles; Random Allocation; Regeneration; Seminiferous Tubules; Signal Transduction; Spermatids; Spermatocytes; Spermatogenesis; Spermatogonia; Stem Cells; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2	2016
Endoglin targeting inhibits tumor angiogenesis and metastatic spread in breast cancer. Oncogene, 2016, 08-04, Volume: 35, Issue:31 Topics: Animals; Antibodies, Monoclonal; Breast Neoplasms; Endoglin; Female; Humans; Indoles; Neoplasm Metastasis; Neovascularization, Pathologic; Pyrroles; Smad1 Protein; Vascular Endothelial Growth Factor A; Zebrafish	2016
Synthesis and preliminary evaluation of 5,7-dimethyl-2-aryl-3H-pyrrolizin-3-ones as angiogenesis inhibitors. Bioorganic & medicinal chemistry letters, 2016, Apr-01, Volume: 26, Issue:7 Topics: Angiogenesis Inhibitors; Animals; Aorta; Human Umbilical Vein Endothelial Cells; Humans; Indoles; Methylation; Models, Molecular; Neovascularization, Physiologic; Pyrroles; Rats; Sunitinib	2016
Thyroid Transcription Factor 1 Reprograms Angiogenic Activities of Secretome. Scientific reports, 2016, Feb-25, Volume: 6 Topics: A549 Cells; Angiogenic Proteins; Antibodies; Blotting, Western; Cell Hypoxia; Cell Line, Tumor; Cell Survival; Culture Media, Conditioned; Cytokines; Enzyme-Linked Immunosorbent Assay; Exosomes; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indoles; Lung Neoplasms; Neovascularization, Physiologic; Nuclear Proteins; Promoter Regions, Genetic; Pyrroles; Real-Time Polymerase Chain Reaction; RNA Interference; RNA, Small Interfering; Thyroid Nuclear Factor 1; TOR Serine-Threonine Kinases; Transcription Factors; Up-Regulation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2	2016
Detrimental Impact of Vasopressin V2 Receptor Antagonism in a SU5416/Hypoxia/Normoxia-Exposed Rat Model of Pulmonary Arterial Hypertension. Circulation journal : official journal of the Japanese Circulation Society, 2016, Volume: 80, Issue:4 Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Disease Models, Animal; Hypertension, Pulmonary; Hypoxia; Indoles; Male; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Vasopressin; Up-Regulation; Ventricular Remodeling	2016
ACE2 Antagonizes VEGFa to Reduce Vascular Permeability During Acute Lung Injury. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2016, Volume: 38, Issue:3 Topics: Acute Lung Injury; Angiotensin-Converting Enzyme 2; Animals; Bleomycin; Capillary Permeability; Endothelial Cells; Gene Expression Regulation; Indoles; Mice; Peptidyl-Dipeptidase A; Porphyrins; Pyrroles; Vascular Endothelial Growth Factor A; Verteporfin	2016
The Na+/H+ exchanger contributes to increased smooth muscle proliferation and migration in a rat model of pulmonary arterial hypertension. Physiological reports, 2016, Volume: 4, Issue:5 Topics: Animals; Cell Movement; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Hypertension, Pulmonary; Indoles; Male; Myocytes, Smooth Muscle; Pyrroles; Rats; Rats, Wistar; Sodium-Hydrogen Exchangers	2016
Pneumonectomy combined with SU5416 induces severe pulmonary hypertension in rats. American journal of physiology. Lung cellular and molecular physiology, 2016, 06-01, Volume: 310, Issue:11 Topics: Animals; Blood Pressure; Disease Models, Animal; Hypertension, Pulmonary; Indoles; Male; Pneumonectomy; Pyrroles; Rats, Sprague-Dawley	2016
Mechanisms of SU5416, an inhibitor of vascular endothelial growth factor receptor, as a radiosensitizer for colon cancer cells. Oncology reports, 2016, Volume: 36, Issue:2 Topics: Adenocarcinoma; Aging; Antineoplastic Agents; Apoptosis; beta-Galactosidase; Cell Line, Tumor; Cell Movement; Colonic Neoplasms; DNA Repair; HCT116 Cells; HT29 Cells; Humans; Indoles; Neoplasm Invasiveness; Pyrroles; Radiation Tolerance; Radiation-Sensitizing Agents; Reactive Oxygen Species; Receptors, Vascular Endothelial Growth Factor	2016
Endothelial hyperpermeability in severe pulmonary arterial hypertension: role of store-operated calcium entry. American journal of physiology. Lung cellular and molecular physiology, 2016, 09-01, Volume: 311, Issue:3 Topics: Animals; Arterial Pressure; Calcium Signaling; Cell Hypoxia; Endothelium, Vascular; Hypertension, Pulmonary; Indoles; Male; Permeability; Pyrroles; Rats, Inbred F344; Thapsigargin; TRPC Cation Channels	2016
Glycolytic regulation of cell rearrangement in angiogenesis. Nature communications, 2016, 07-20, Volume: 7 Topics: Adenosine Triphosphate; Antigens, CD; Cadherins; Computer Simulation; Gene Knockdown Techniques; Glycolysis; Human Umbilical Vein Endothelial Cells; Humans; Indoles; Models, Biological; Neovascularization, Physiologic; Phosphofructokinase-2; Pseudopodia; Pyridines; Pyrroles; Vascular Endothelial Growth Factor A	2016
Inhibition of Vascular Endothelial Growth Factor Receptor 2 Exacerbates Loss of Lower Motor Neurons and Axons during Experimental Autoimmune Encephalomyelitis. PloS one, 2016, Volume: 11, Issue:7 Topics: Angiogenesis Inhibitors; Animals; Axons; Encephalomyelitis, Autoimmune, Experimental; Female; Indoles; Lumbar Vertebrae; Mice; Mice, Inbred C57BL; Motor Neurons; Pyrroles; Signal Transduction; Spinal Cord; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2	2016
Estrogen Preserves Pulsatile Pulmonary Arterial Hemodynamics in Pulmonary Arterial Hypertension. Annals of biomedical engineering, 2017, Volume: 45, Issue:3 Topics: Animals; Estrogens; Female; Hypertension, Pulmonary; Indoles; Mice; Ovariectomy; Pulmonary Artery; Pulsatile Flow; Pyrroles; Vascular Resistance	2017
Erythropoietin improves hypoxic-ischemic encephalopathy in neonatal rats after short-term anoxia by enhancing angiogenesis. Brain research, 2016, 11-15, Volume: 1651 Topics: Angiogenesis Inducing Agents; Animals; Animals, Newborn; Cognition; Disease Models, Animal; Erythropoietin; Hippocampus; Hypoxia; Hypoxia-Ischemia, Brain; Indoles; Male; Pyrroles; Random Allocation; Rats, Sprague-Dawley; Signal Transduction; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2; White Matter	2016
Osteoprotegerin Disruption Attenuates HySu-Induced Pulmonary Hypertension Through Integrin αvβ3/FAK/AKT Pathway Suppression. Circulation. Cardiovascular genetics, 2017, Volume: 10, Issue:1 Topics: Animals; Arterial Pressure; Case-Control Studies; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Female; Focal Adhesion Kinase 1; Humans; Hypertension, Pulmonary; Hypoxia; Indoles; Integrin alphaVbeta3; Male; Mice, Knockout; Middle Aged; Monocrotaline; Muscle, Smooth, Vascular; Osteoprotegerin; Proto-Oncogene Proteins c-akt; Pulmonary Artery; Pyrroles; Rats, Sprague-Dawley; RNA Interference; Severity of Illness Index; Signal Transduction; Transfection; Vascular Remodeling; Walk Test	2017
Using Affinity To Provide Long-Term Delivery of Antiangiogenic Drugs in Cancer Therapy. Molecular pharmaceutics, 2017, 03-06, Volume: 14, Issue:3 Topics: 2-Methoxyestradiol; Angiogenesis Inhibitors; Animals; Cell Line, Tumor; Cellulose; Cyclodextrins; Drug Delivery Systems; Estradiol; Female; Glioblastoma; Humans; Indoles; Mice; Mice, Nude; ortho-Aminobenzoates; Pyrroles; Silybin; Silymarin	2017
Chronic Embolic Pulmonary Hypertension Caused by Pulmonary Embolism and Vascular Endothelial Growth Factor Inhibition. The American journal of pathology, 2017, Volume: 187, Issue:4 Topics: Animals; Cardiomegaly; Cell Proliferation; Chronic Disease; Heart Function Tests; Hemodynamics; Hyperplasia; Hypertension, Pulmonary; Hypoxia; Indoles; Ki-67 Antigen; Lung; Male; Microspheres; Oxygen Consumption; P-Selectin; Partial Pressure; Physical Conditioning, Animal; Plasminogen Activator Inhibitor 1; Polystyrenes; Pulmonary Embolism; Pyrroles; Rats, Sprague-Dawley; Tissue Inhibitor of Metalloproteinase-1; Vascular Endothelial Growth Factor A; Ventricular Dysfunction	2017
Synthesis and evaluation of 5-(arylthio)-9H-pyrimido[4,5-b]indole-2,4-diamines as receptor tyrosine kinase and thymidylate synthase inhibitors and as antitumor agents. Bioorganic & medicinal chemistry letters, 2017, 04-01, Volume: 27, Issue:7 Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Cell Line, Tumor; Cisplatin; Folic Acid Antagonists; Heterocyclic Compounds, 3-Ring; Humans; Indoles; Mice; Pemetrexed; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Receptor Protein-Tyrosine Kinases; Receptor, Platelet-Derived Growth Factor beta; Thymidylate Synthase; Vascular Endothelial Growth Factor Receptor-2; Xenograft Model Antitumor Assays	2017
Vegf signaling promotes vascular endothelial differentiation by modulating etv2 expression. Developmental biology, 2017, 04-15, Volume: 424, Issue:2 Topics: Animals; Arteries; Biomarkers; Cell Count; Cell Differentiation; Embryo, Nonmammalian; Endothelial Cells; Gene Expression Regulation, Developmental; Gene Knockdown Techniques; Indoles; Models, Biological; Morpholinos; Mutation; Pyrroles; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Somites; Vascular Endothelial Growth Factor A; Veins; Zebrafish; Zebrafish Proteins	2017
RAGE-mediated extracellular matrix proteins accumulation exacerbates HySu-induced pulmonary hypertension. Cardiovascular research, 2017, May-01, Volume: 113, Issue:6 Topics: Animals; Case-Control Studies; Cell Hypoxia; Cells, Cultured; Cytoskeletal Proteins; Disease Models, Animal; DNA-Binding Proteins; Extracellular Matrix Proteins; Extracellular Signal-Regulated MAP Kinases; Female; HMGB1 Protein; Humans; Hypertension, Pulmonary; Indoles; Intracellular Signaling Peptides and Proteins; Ligands; LIM Domain Proteins; Male; Middle Aged; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pulmonary Artery; Pyrroles; Receptor for Advanced Glycation End Products; RNA Interference; S100 Calcium Binding Protein beta Subunit; Transfection; Vascular Remodeling	2017
The aryl hydrocarbon receptor is required for induction of p21cip1/waf1 expression and growth inhibition by SU5416 in hepatoma cells. Oncotarget, 2017, Apr-11, Volume: 8, Issue:15 Topics: Antineoplastic Agents; Aryl Hydrocarbon Receptor Nuclear Translocator; Cell Line; Cell Proliferation; Cell Survival; Cyclin-Dependent Kinase Inhibitor p21; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Indoles; Liver Neoplasms; Protein Kinase Inhibitors; Pyrroles; Receptors, Aryl Hydrocarbon; Signal Transduction	2017
Capillary Degeneration and Right Ventricular Remodeling Due to Hypoxic Stress with Sugen5416. Current vascular pharmacology, 2017, Volume: 15, Issue:6 Topics: Animals; Blood Pressure; Capillaries; Disease Models, Animal; Endothelial Cells; Heart Ventricles; Hypertension, Pulmonary; Hypoxia; In Situ Nick-End Labeling; Indoles; Male; MAP Kinase Signaling System; Myocardium; Myocytes, Cardiac; Oxidative Stress; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Vascular Endothelial Growth Factor; RNA, Messenger; Ventricular Remodeling	2017
Pharmacological Inhibition of mTOR Kinase Reverses Right Ventricle Remodeling and Improves Right Ventricle Structure and Function in Rats. American journal of respiratory cell and molecular biology, 2017, Volume: 57, Issue:5 Topics: Animals; Cell Proliferation; Cell Survival; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Indoles; Male; Myocytes, Cardiac; Protein Kinase Inhibitors; Pulmonary Artery; Pyrroles; Rats, Sprague-Dawley; TOR Serine-Threonine Kinases; Ventricular Remodeling	2017
Inhibition of fibroblast growth factor receptor with AZD4547 mitigates juvenile nasopharyngeal angiofibroma. International forum of allergy & rhinology, 2017, Volume: 7, Issue:10 Topics: Angiofibroma; Antineoplastic Agents; Benzamides; Cell Movement; Cell Proliferation; Cells, Cultured; Fibroblasts; Human Umbilical Vein Endothelial Cells; Humans; Indoles; Nasopharyngeal Neoplasms; Piperazines; Pyrazoles; Pyrroles; Receptors, Fibroblast Growth Factor; Receptors, Vascular Endothelial Growth Factor	2017
Endothelial cell-related autophagic pathways in Sugen/hypoxia-exposed pulmonary arterial hypertensive rats. American journal of physiology. Lung cellular and molecular physiology, 2017, Nov-01, Volume: 313, Issue:5 Topics: Animals; Autophagy; Cell Proliferation; Endothelial Cells; Hemodynamics; Hypertension, Pulmonary; Hypoxia; Indoles; Lung; Male; Pulmonary Artery; Pyrroles; Rats, Sprague-Dawley; Receptors, Vascular Endothelial Growth Factor	2017
Natural reversal of pulmonary vascular remodeling and right ventricular remodeling in SU5416/hypoxia-treated Sprague-Dawley rats. PloS one, 2017, Volume: 12, Issue:8 Topics: Animals; Blotting, Western; Fibrosis; Heart Ventricles; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Indoles; Lung; Male; Metabolomics; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; Ventricular Remodeling	2017
Role of the Aryl Hydrocarbon Receptor in Sugen 5416-induced Experimental Pulmonary Hypertension. American journal of respiratory cell and molecular biology, 2018, Volume: 58, Issue:3 Topics: Active Transport, Cell Nucleus; Animals; Apoptosis; Aromatase; Aryl Hydrocarbon Receptor Nuclear Translocator; Azo Compounds; Cell Hypoxia; Cell Proliferation; Cytochrome P-450 CYP1A1; Endothelial Cells; Estrogens; Female; Humans; Hypertension, Pulmonary; Hypoxia-Inducible Factor 1, alpha Subunit; Indoles; Lung; Muscle, Smooth, Vascular; Pyrazoles; Pyrroles; Rats; Rats, Wistar; Receptors, Aryl Hydrocarbon; RNA, Messenger; Vascular Endothelial Growth Factor A	2018
Ginsenoside Rb1 prevents homocysteine-induced EPC dysfunction via VEGF/p38MAPK and SDF-1/CXCR4 activation. Scientific reports, 2017, 10-12, Volume: 7, Issue:1 Topics: Animals; Benzylamines; Cell Movement; Cell Survival; Chemokine CXCL12; Cyclams; Endothelial Progenitor Cells; Ginsenosides; Heterocyclic Compounds; Homocysteine; Indoles; Male; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyrroles; Rats; Rats, Sprague-Dawley; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2	2017
INGAP-PP effects on β-cell mass and function are related to its positive effect on islet angiogenesis and VEGFA production. Molecular and cellular endocrinology, 2018, 07-15, Volume: 470 Topics: Animals; Apoptosis; Body Weight; Cell Size; Cytokines; DNA; Feeding Behavior; Glucose; Glucose Tolerance Test; Indoles; Insulin; Insulin-Secreting Cells; Integrin beta1; Male; Neovascularization, Physiologic; Peptide Fragments; Pyrroles; Rats, Wistar; RNA, Messenger; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2	2018
Rational modification of semaxanib and sunitinib for developing a tumor growth inhibitor targeting ATP binding site of tyrosine kinase. Bioorganic & medicinal chemistry letters, 2018, 01-15, Volume: 28, Issue:2 Topics: Adenosine Triphosphate; Antineoplastic Agents; Binding Sites; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Indoles; Molecular Docking Simulation; Molecular Structure; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrroles; Structure-Activity Relationship; Sunitinib	2018
Inhibition of nitric oxide synthase unmasks vigorous vasoconstriction in established pulmonary arterial hypertension. Physiological reports, 2017, Volume: 5, Issue:23 Topics: Acetylcholine; Animals; Blood Pressure; Cyclic GMP; Hypertension, Pulmonary; Indoles; Lung; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Protein Kinase Inhibitors; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Vascular Endothelial Growth Factor; Vasoconstriction	2017
Inhibition of VEGF Signaling Reduces Diabetes-Exacerbated Brain Swelling, but Not Infarct Size, in Large Cerebral Infarction in Mice. Translational stroke research, 2018, Volume: 9, Issue:5 Topics: Animals; Blood Glucose; Brain Edema; Brain Ischemia; Cerebral Infarction; Diabetes Mellitus, Experimental; Disease Models, Animal; Glucose Tolerance Test; Indoles; Insulin; Male; Mice; Mice, Inbred C57BL; Protein Kinase Inhibitors; Proteoglycans; Pyrroles; RNA, Messenger; Signal Transduction; Stroke; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2	2018
Reactive oxygen species induced Ca American journal of physiology. Lung cellular and molecular physiology, 2018, 05-01, Volume: 314, Issue:5 Topics: Angiogenesis Inhibitors; Animals; Calcium; Cells, Cultured; Endothelium, Vascular; Hypertension, Pulmonary; Hypoxia; Indoles; Male; Microvessels; Pulmonary Artery; Pyrroles; Rats; Rats, Wistar; TRPV Cation Channels; Vascular Diseases	2018
Role of the Aryl Hydrocarbon Receptor in Su5416/Hypoxia-induced Pulmonary Hypertension: A New Mechanism for an "Old" Model. American journal of respiratory cell and molecular biology, 2018, Volume: 58, Issue:3 Topics: Animals; Apoptosis; Azo Compounds; Cell Hypoxia; Disease Models, Animal; Emphysema; Endothelial Cells; Humans; Hypertension, Pulmonary; Indoles; Mice; Protein Kinase Inhibitors; Pyrazoles; Pyrroles; Rats; Receptors, Aryl Hydrocarbon; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2	2018
[Correlation between expressions of VEGF and TRPC6 and their roles in podocyte injury in rats with diabetic nephropathy]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2018, Mar-20, Volume: 38, Issue:3 Topics: Animals; Chromones; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Indoles; Kidney; Membrane Proteins; Morpholines; Podocytes; Pyrroles; Random Allocation; Rats; Rats, Sprague-Dawley; TRPC Cation Channels; Vascular Endothelial Growth Factor A	2018
miR-1 is increased in pulmonary hypertension and downregulates Kv1.5 channels in rat pulmonary arteries. The Journal of physiology, 2019, Volume: 597, Issue:4 Topics: Action Potentials; Animals; Cell Hypoxia; Chlorocebus aethiops; COS Cells; Down-Regulation; Hypertension, Pulmonary; Indoles; Kv1.5 Potassium Channel; Male; MicroRNAs; Myocytes, Smooth Muscle; Potassium Channel Blockers; Pulmonary Artery; Pyrroles; Rats; Rats, Wistar	2019
Vascular Adaptation of the Right Ventricle in Experimental Pulmonary Hypertension. American journal of respiratory cell and molecular biology, 2018, Volume: 59, Issue:4 Topics: Adaptation, Physiological; Animals; Apoptosis; Cell Proliferation; Endothelial Cells; Female; Heart Ventricles; Hypertension, Pulmonary; Hypoxia; Indoles; Mice, Inbred C57BL; Pyrroles; Rats, Sprague-Dawley	2018
Inhibition of CRTH2-mediated Th2 activation attenuates pulmonary hypertension in mice. The Journal of experimental medicine, 2018, 08-06, Volume: 215, Issue:8 Topics: Adoptive Transfer; Adult; Animals; Antibodies; Blood Pressure; Bone Marrow; Cell Proliferation; Chimera; Chronic Disease; Disease Models, Animal; Female; Gene Deletion; Humans; Hypertension, Pulmonary; Hypoxia; Immunity; Indoles; Lung; Lymphocyte Activation; Male; Mice; Ovalbumin; Pulmonary Artery; Pyrroles; Receptors, Immunologic; Receptors, Prostaglandin; STAT6 Transcription Factor; Th2 Cells; Up-Regulation	2018
The Sugen 5416/Hypoxia Mouse Model of Pulmonary Arterial Hypertension. Methods in molecular biology (Clifton, N.J.), 2018, Volume: 1816 Topics: Animals; Disease Models, Animal; Humans; Hypertension, Pulmonary; Hypoxia; Indoles; Male; Mice; Mice, Inbred C57BL; Pulmonary Artery; Pyrroles; Vascular Remodeling	2018
Nintedanib improves cardiac fibrosis but leaves pulmonary vascular remodelling unaltered in experimental pulmonary hypertension. Cardiovascular research, 2019, 02-01, Volume: 115, Issue:2 Topics: Adult; Animals; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Endothelial Cells; Extracellular Matrix; Female; Fibroblasts; Fibrosis; Humans; Indoles; Male; Myocardium; Protein Kinase Inhibitors; Pulmonary Arterial Hypertension; Pulmonary Artery; Pyrroles; Rats, Sprague-Dawley; Vascular Remodeling; Ventricular Function, Right; Ventricular Remodeling; Young Adult	2019
Efficacy of treprostinil in the SU5416-hypoxia model of severe pulmonary arterial hypertension: haemodynamic benefits are not associated with improvements in arterial remodelling. British journal of pharmacology, 2018, Volume: 175, Issue:20 Topics: Angiogenesis Inhibitors; Animals; Antihypertensive Agents; Epoprostenol; Hemodynamics; Hypertension, Pulmonary; Hypoxia; Indoles; Male; Protein Kinase Inhibitors; Pyrroles; Rats, Sprague-Dawley; Vascular Remodeling; Vasodilator Agents; Ventricular Function, Right	2018
Endothelial Progenitor Cells and Notch-1 Signaling as Markers of Alveolar Endothelium Regeneration in Pulmonary Emphysema. Bulletin of experimental biology and medicine, 2018, Volume: 166, Issue:2 Topics: Animals; Antigens, CD; Complex Mixtures; Endothelial Progenitor Cells; Endothelium; Female; Galactosamine; Gene Expression Regulation; Indoles; Lung; Mice; Mice, Inbred C57BL; Neovascularization, Physiologic; Nicotiana; Pancreatic Elastase; Pulmonary Emphysema; Pyrroles; Receptor, Notch1; Regeneration; Signal Transduction; Vascular Endothelial Growth Factor Receptor-1	2018
CrossTalk opposing view: The mouse SuHx model is not a good model of pulmonary arterial hypertension. The Journal of physiology, 2019, Volume: 597, Issue:4 Topics: Angiogenesis Inhibitors; Animals; Disease Models, Animal; Hypertension, Pulmonary; Hypoxia; Indoles; Mice; Pyrroles; Receptors, Vascular Endothelial Growth Factor	2019
CrossTalk proposal: The mouse SuHx model is a good model of pulmonary arterial hypertension. The Journal of physiology, 2019, Volume: 597, Issue:4 Topics: Angiogenesis Inhibitors; Animals; Disease Models, Animal; Hypertension, Pulmonary; Hypoxia; Indoles; Mice; Pyrroles; Receptors, Vascular Endothelial Growth Factor	2019
Bone Marrow-Derived Proangiogenic Cells Mediate Pulmonary Arteriole Stiffening via Serotonin 2B Receptor Dependent Mechanism. Circulation research, 2018, 12-07, Volume: 123, Issue:12 Topics: Angiogenesis Inhibitors; Animals; Arterioles; Cell Lineage; Cells, Cultured; Hypertension, Pulmonary; Indoles; Lung; Mice; Mice, Inbred C57BL; Myeloid Progenitor Cells; Pyrroles; Receptor, Serotonin, 5-HT2B; Vascular Stiffness	2018
Macrophage-Derived Legumain Promotes Pulmonary Hypertension by Activating the MMP (Matrix Metalloproteinase)-2/TGF (Transforming Growth Factor)-β1 Signaling. Arteriosclerosis, thrombosis, and vascular biology, 2019, Volume: 39, Issue:4 Topics: Animals; Caspase Inhibitors; Cysteine Endopeptidases; Extracellular Matrix Proteins; Female; Follow-Up Studies; Humans; Hypertension, Pulmonary; Hypoxia; Indoles; Inflammation; Lung; Macrophages; Male; Matrix Metalloproteinase 2; Mice; Middle Aged; Monocrotaline; Pyrroles; Rats; Severity of Illness Index; Signal Transduction; Transforming Growth Factor beta1; Vascular Remodeling	2019
Beneficial effects of mesenchymal stem cell delivery via a novel cardiac bioscaffold on right ventricles of pulmonary arterial hypertensive rats. American journal of physiology. Heart and circulatory physiology, 2019, 05-01, Volume: 316, Issue:5 Topics: Animals; Arterial Pressure; Cells, Cultured; Disease Models, Animal; Fibrosis; Hypertrophy, Right Ventricular; Hypoxia; Indoles; Male; Mesenchymal Stem Cell Transplantation; Myocardial Contraction; Myocardium; Pulmonary Arterial Hypertension; Pulmonary Artery; Pyrroles; Rats, Sprague-Dawley; Recovery of Function; Regeneration; Tissue Scaffolds; Ventricular Dysfunction, Right; Ventricular Function, Right; Ventricular Remodeling; von Willebrand Factor	2019
Prototyping kinase inhibitor-cytotoxin anticancer mutual prodrugs activated by tumour hypoxia: A chemical proof of concept study. Bioorganic & medicinal chemistry letters, 2019, 05-15, Volume: 29, Issue:10 Topics: Alcohols; Amines; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cytotoxins; Drug Screening Assays, Antitumor; Floxuridine; Humans; Indoles; Molecular Structure; Prodrugs; Proof of Concept Study; Protein Kinase Inhibitors; Pyrroles; Structure-Activity Relationship; Tumor Hypoxia	2019
The Left Pneumonectomy Combined with Monocrotaline or Sugen as a Model of Pulmonary Hypertension in Rats. Journal of visualized experiments : JoVE, 2019, 03-08, Issue:145 Topics: Animals; Disease Models, Animal; Hypertension, Pulmonary; Indoles; Lung; Male; Monocrotaline; Pneumonectomy; Pulmonary Artery; Pyrroles; Rats, Sprague-Dawley	2019
Injury-Induced Shedding of Extracellular Vesicles Depletes Endothelial Cells of Cav-1 (Caveolin-1) and Enables TGF-β (Transforming Growth Factor-β)-Dependent Pulmonary Arterial Hypertension. Arteriosclerosis, thrombosis, and vascular biology, 2019, Volume: 39, Issue:6 Topics: Adolescent; Adult; Aged; Animals; Bone Morphogenetic Protein Receptors, Type II; Case-Control Studies; Caveolin 1; Cell Proliferation; Disease Models, Animal; Endothelial Cells; Extracellular Vesicles; Female; Humans; Hypoxia; Indoles; Male; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Nitric Oxide Synthase Type III; Pulmonary Arterial Hypertension; Pyrroles; Rats, Sprague-Dawley; Signal Transduction; Smad Proteins; Transforming Growth Factor beta; Vascular Remodeling; Young Adult	2019
Inhibition of miR-495 Improves Both Vascular Remodeling and Angiogenesis in Pulmonary Hypertension. Journal of vascular research, 2019, Volume: 56, Issue:2 Topics: Angiogenic Proteins; Animals; Cell Cycle Checkpoints; Cell Movement; Cell Proliferation; Cells, Cultured; Dependovirus; Disease Models, Animal; Genetic Therapy; Genetic Vectors; Hypertension, Pulmonary; Hypoxia; Indoles; Lung; Male; Mice, Inbred C57BL; MicroRNAs; Microvessels; Neovascularization, Physiologic; Pyrroles; Recovery of Function; Signal Transduction; Vascular Remodeling	2019
Severe Emphysema in the SU5416/Hypoxia Rat Model of Pulmonary Hypertension. American journal of respiratory and critical care medicine, 2019, 08-15, Volume: 200, Issue:4 Topics: Animals; Disease Models, Animal; Hypertension, Pulmonary; Hypoxia; Indoles; Protein Kinase Inhibitors; Pulmonary Emphysema; Pyrroles; Rats; X-Ray Microtomography	2019
Targeting cyclin-dependent kinases for the treatment of pulmonary arterial hypertension. Nature communications, 2019, 05-17, Volume: 10, Issue:1 Topics: Animals; Cell Line; Cyclin-Dependent Kinases; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Humans; Indoles; Lung; Male; Mice; Mice, Inbred C57BL; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Piperazines; Protein Kinase Inhibitors; Pulmonary Artery; Pyridines; Pyrroles; Rats; Rats, Inbred WKY; Rats, Sprague-Dawley; Treatment Outcome	2019
Identification of Celastramycin as a Novel Therapeutic Agent for Pulmonary Arterial Hypertension. Circulation research, 2019, 07-19, Volume: 125, Issue:3 Topics: Animals; Cells, Cultured; Cytokines; Disease Models, Animal; Drug Evaluation, Preclinical; Energy Metabolism; High-Throughput Screening Assays; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Indoles; Male; Metabolome; Mice; Mitochondria; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Naphthoquinones; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Pulmonary Arterial Hypertension; Pulmonary Artery; Pyrroles; Rats; Reactive Oxygen Species; Resorcinols; Transcription Factors	2019
SU5416 does not attenuate early RV angiogenesis in the murine chronic hypoxia PH model. Respiratory research, 2019, Jun-17, Volume: 20, Issue:1 Topics: Angiogenesis Inhibitors; Animals; Chronic Disease; Heart Ventricles; Hypertension, Pulmonary; Hypoxia; Indoles; Male; Mice; Mice, Inbred C57BL; Neovascularization, Pathologic; Pyrroles	2019
VEGF and FGF signaling during head regeneration in hydra. Gene, 2019, Oct-30, Volume: 717 Topics: Animals; Computer Simulation; Fibroblast Growth Factor 1; Fibroblast Growth Factors; Gene Expression Regulation; Head; Humans; Hydra; Indoles; Protein Domains; Pyrroles; Receptor, Fibroblast Growth Factor, Type 1; Regeneration; Signal Transduction; Structural Homology, Protein; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2	2019
Reply to Bogaard American journal of respiratory and critical care medicine, 2019, 12-01, Volume: 200, Issue:11 Topics: Animals; Emphysema; Hypertension, Pulmonary; Hypoxia; Indoles; Phenotype; Pulmonary Arterial Hypertension; Pyrroles; Rats	2019
Emphysema Is-at the Most-Only a Mild Phenotype in the Sugen/Hypoxia Rat Model of Pulmonary Arterial Hypertension. American journal of respiratory and critical care medicine, 2019, 12-01, Volume: 200, Issue:11 Topics: Animals; Emphysema; Hypertension, Pulmonary; Hypoxia; Indoles; Phenotype; Pulmonary Arterial Hypertension; Pyrroles; Rats	2019
Regulation of mitochondrial fragmentation in microvascular endothelial cells isolated from the SU5416/hypoxia model of pulmonary arterial hypertension. American journal of physiology. Lung cellular and molecular physiology, 2019, 11-01, Volume: 317, Issue:5 Topics: Angiogenesis Inhibitors; Animals; Calcium; Cells, Cultured; Endothelial Cells; Hypoxia; Indoles; Lung; Male; Mitochondria; Oxygen Consumption; Pulmonary Arterial Hypertension; Pyrroles; Rats; Rats, Wistar; Reactive Oxygen Species; Vascular Remodeling	2019
Epigallocatechin-3-gallate inhibits tumor angiogenesis: involvement of endoglin/Smad1 signaling in human umbilical vein endothelium cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019, Volume: 120 Topics: Angiogenesis Inhibitors; Catechin; Cell Movement; Cell Proliferation; Cells, Cultured; Endoglin; Human Umbilical Vein Endothelial Cells; Humans; Indoles; Neoplasm Invasiveness; Neovascularization, Pathologic; Pyrroles; Signal Transduction; Smad1 Protein; Vascular Endothelial Growth Factor A	2019
Mesenchymal Stem Cell Extracellular Vesicles Reverse Sugen/Hypoxia Pulmonary Hypertension in Rats. American journal of respiratory cell and molecular biology, 2020, Volume: 62, Issue:5 Topics: Animals; Extracellular Vesicles; Fibroblasts; Humans; Hypertension, Pulmonary; Hypoxia; Indoles; Macrophage Activation; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; MicroRNAs; Muscle, Smooth; Neovascularization, Physiologic; Pyrroles; Rats, Sprague-Dawley; Vascular Remodeling; von Willebrand Factor	2020
The Adult Sprague-Dawley Sugen-Hypoxia Rat Is Still "the One:" A Model of Group 1 Pulmonary Hypertension: Reply to Le Cras and Abman. American journal of respiratory and critical care medicine, 2020, 03-01, Volume: 201, Issue:5 Topics: Animals; Emphysema; Hypertension, Pulmonary; Hypoxia; Indoles; Pyrroles; Rats; Rats, Sprague-Dawley	2020
Early Disruption of VEGF Receptor Signaling and the Risk for Adult Emphysema. American journal of respiratory and critical care medicine, 2020, 03-01, Volume: 201, Issue:5 Topics: Adult; Animals; Emphysema; Hypertension, Pulmonary; Hypoxia; Indoles; Pulmonary Emphysema; Pyrroles; Rats; Receptors, Vascular Endothelial Growth Factor	2020
Neonatal excitotoxicity modifies blood-brain barrier properties increasing its susceptibility to hypertonic shock in adulthood. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2020, Volume: 80, Issue:4 Topics: Animals; Animals, Newborn; Blood-Brain Barrier; Brain; Brain Chemistry; Indoles; Male; Osmotic Pressure; Pyrroles; Rats; Rats, Wistar; Sodium Glutamate; Vascular Endothelial Growth Factor Receptor-2	2020
Paeoniflorin Ameliorates Chronic Hypoxia/SU5416-Induced Pulmonary Arterial Hypertension by Inhibiting Endothelial-to-Mesenchymal Transition. Drug design, development and therapy, 2020, Volume: 14 Topics: Animals; Cells, Cultured; Chronic Disease; Disease Models, Animal; Endothelial Cells; Epithelial-Mesenchymal Transition; Glucosides; Humans; Hypoxia; Indoles; Injections, Subcutaneous; Male; Monoterpenes; Oxygen; Pulmonary Arterial Hypertension; Pyrroles; Rats; Rats, Sprague-Dawley	2020
A novel rat model of pulmonary hypertension induced by mono treatment with SU5416. Hypertension research : official journal of the Japanese Society of Hypertension, 2020, Volume: 43, Issue:8 Topics: Animals; Blood Pressure; Cardiac Output; Disease Models, Animal; Heart; Hypertension, Pulmonary; Indoles; Lung; Male; Pyrroles; Rats; Rats, Sprague-Dawley; Vascular Resistance	2020
Endothelial HIF-2α as a Key Endogenous Mediator Preventing Emphysema. American journal of respiratory and critical care medicine, 2020, 10-01, Volume: 202, Issue:7 Topics: Angiogenesis Inhibitors; Animals; Basic Helix-Loop-Helix Transcription Factors; Deferoxamine; Disease Models, Animal; Endothelial Cells; Hepatocyte Growth Factor; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indoles; Iron Chelating Agents; Lung; Mice; Mice, Knockout; Microvessels; Pericytes; Pulmonary Circulation; Pulmonary Disease, Chronic Obstructive; Pulmonary Emphysema; Pyrroles; Smoke	2020
Induction and Characterization of Pulmonary Hypertension in Mice using the Hypoxia/SU5416 Model. Journal of visualized experiments : JoVE, 2020, 06-03, Issue:160 Topics: Animals; Cell Hypoxia; Disease Models, Animal; Fibrosis; Heart Ventricles; Humans; Hydrogen-Ion Concentration; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Indoles; Male; Mice; Pulmonary Artery; Pulmonary Circulation; Pyrroles; Vascular Endothelial Growth Factor A; Vascular Remodeling; Ventricular Remodeling	2020
Periostin: A Potential Therapeutic Target For Pulmonary Hypertension? Circulation research, 2020, 10-09, Volume: 127, Issue:9 Topics: Animals; Biomarkers; Bone Morphogenetic Protein Receptors, Type II; Cell Adhesion Molecules; Cell Hypoxia; Cell Movement; Cell Proliferation; Disease Models, Animal; Endothelial Cells; Endothelin-1; Humans; Hypertension, Pulmonary; Hypoxia-Inducible Factor 1, alpha Subunit; Indoles; Membrane Glycoproteins; Mice; Myocytes, Smooth Muscle; Protein-Tyrosine Kinases; Pulmonary Artery; Pyrroles; Receptor, trkB; Vascular Endothelial Growth Factor A	2020
The need for hypoxic exposure in experimental PAH - Comment on Chen et al.: a novel rat model of pulmonary hypertension induced by mono treatment with SU5416. Hypertension research : official journal of the Japanese Society of Hypertension, 2020, Volume: 43, Issue:11 Topics: Animals; Hypertension, Pulmonary; Hypoxia; Indoles; Pyrroles; Rats	2020
The selective PGI2 receptor agonist selexipag ameliorates Sugen 5416/hypoxia-induced pulmonary arterial hypertension in rats. PloS one, 2020, Volume: 15, Issue:10 Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetamides; Animals; Cell Proliferation; Collagen Type I; Disease Models, Animal; Heart Ventricles; Hemodynamics; Hypertrophy, Right Ventricular; Hypoxia; Indoles; Lung; Male; Pulmonary Arterial Hypertension; Pyrazines; Pyrroles; Rats, Sprague-Dawley; Receptors, Epoprostenol; Systole; Vascular Remodeling	2020
Efficacy of the thromboxane receptor antagonist NTP42 alone, or in combination with sildenafil, in the sugen/hypoxia-induced model of pulmonary arterial hypertension. European journal of pharmacology, 2020, Dec-15, Volume: 889 Topics: Angiogenesis Inhibitors; Animals; Drug Therapy, Combination; Hypoxia; Indoles; Male; Pulmonary Arterial Hypertension; Pyrroles; Rats; Rats, Wistar; Receptors, Thromboxane A2, Prostaglandin H2; Sildenafil Citrate; Treatment Outcome; Vasodilator Agents	2020
Equivalence Study of Semaxanib from Different Suppliers. American journal of respiratory cell and molecular biology, 2020, Volume: 63, Issue:6 Topics: Animals; Cell Culture Techniques; Endothelial Cells; Humans; Indoles; Pyrroles	2020
Increased MAO-A Activity Promotes Progression of Pulmonary Arterial Hypertension. American journal of respiratory cell and molecular biology, 2021, Volume: 64, Issue:3 Topics: Animals; Clorgyline; Disease Models, Animal; Disease Progression; Heart Ventricles; Humans; Hypertrophy, Right Ventricular; Indoles; Monoamine Oxidase; Oxidative Stress; Pulmonary Arterial Hypertension; Pulmonary Artery; Pyrroles; Rats; Vascular Remodeling; Vascular Stiffness; Vasodilation	2021
Activation of inflammasomes by tyrosine kinase inhibitors of vascular endothelial growth factor receptor: Implications for VEGFR TKIs-induced immune related adverse events. Toxicology in vitro : an international journal published in association with BIBRA, 2021, Volume: 71 Topics: Antineoplastic Agents; Axitinib; Caspases; HMGB1 Protein; Humans; Indazoles; Indoles; Inflammasomes; Interleukin-1beta; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Receptors, Vascular Endothelial Growth Factor; Sorafenib; Sulfonamides; Sunitinib; THP-1 Cells	2021
Identification of Celastrol as a Novel Therapeutic Agent for Pulmonary Arterial Hypertension and Right Ventricular Failure Through Suppression of Bsg (Basigin)/CyPA (Cyclophilin A). Arteriosclerosis, thrombosis, and vascular biology, 2021, Volume: 41, Issue:3 Topics: Animals; Antihypertensive Agents; Basigin; Cyclophilin A; Disease Models, Animal; Humans; Hypoxia; Indoles; Mice; Mice, Transgenic; Myocytes, Cardiac; Pentacyclic Triterpenes; Pulmonary Arterial Hypertension; Pyrroles; Rats; Triterpenes; Ventricular Dysfunction, Right	2021
Evaluation of right coronary vascular dysfunction in severe pulmonary hypertensive rats using synchrotron radiation microangiography. American journal of physiology. Heart and circulatory physiology, 2021, 03-01, Volume: 320, Issue:3 Topics: Animals; Antihypertensive Agents; Coronary Angiography; Coronary Vessels; Disease Models, Animal; Endothelin Receptor Antagonists; Endothelin-1; Hypertrophy, Right Ventricular; Hypoxia; Indoles; Monocrotaline; Predictive Value of Tests; Pulmonary Arterial Hypertension; Pyrimidines; Pyrroles; Rats, Sprague-Dawley; Severity of Illness Index; Sulfonamides; Synchrotrons; Vasodilation; Ventricular Dysfunction, Right; Ventricular Function, Right; Ventricular Remodeling	2021
Metabolic remodeling in the right ventricle of rats with severe pulmonary arterial hypertension. Molecular medicine reports, 2021, Volume: 23, Issue:4 Topics: Animals; Citric Acid Cycle; Fatty Acids; Glucose; Heart Ventricles; Humans; Hypertrophy, Right Ventricular; Hypoxia; Indoles; Oxidation-Reduction; Pulmonary Arterial Hypertension; Pyrroles; Rats; Rats, Sprague-Dawley; Ventricular Remodeling	2021
Transcriptomic Analysis of Right Ventricular Remodeling in Two Rat Models of Pulmonary Hypertension: Identification and Validation of Epithelial-to-Mesenchymal Transition in Human Right Ventricular Failure. Circulation. Heart failure, 2021, Volume: 14, Issue:2 Topics: Aged; Aged, 80 and over; Angiogenesis Inhibitors; Animals; Disease Models, Animal; Epithelial-Mesenchymal Transition; Female; Gene Expression Profiling; Heart Failure; Heart Ventricles; Humans; Hypoxia; Indoles; Male; Middle Aged; Monocrotaline; Pulmonary Arterial Hypertension; Pyrroles; Rats; Real-Time Polymerase Chain Reaction; RNA-Seq; Transcriptome; Ventricular Dysfunction, Right; Ventricular Remodeling	2021
Cell Tracking Suggests Pathophysiological and Therapeutic Role of Bone Marrow Cells in Sugen5416/Hypoxia Rat Model of Pulmonary Arterial Hypertension. The Canadian journal of cardiology, 2021, Volume: 37, Issue:6 Topics: Angiogenesis Inhibitors; Animals; Bone Marrow Cells; Bone Marrow Transplantation; Cell Tracking; Disease Models, Animal; Female; Hypoxia; Indoles; Lung; Male; Neointima; Pulmonary Arterial Hypertension; Pulmonary Artery; Pyrroles; Rats; Transplantation Chimera; Vascular Remodeling	2021
Immunomodulation Therapy Using Tolerogenic Macrophages in a Rodent Model of Pulmonary Hypertension. Stem cells and development, 2021, 05-15, Volume: 30, Issue:10 Topics: Animals; Disease Models, Animal; Gene Expression Profiling; Humans; Hypertension, Pulmonary; Immune Tolerance; Immunomodulation; Immunotherapy; Indoles; Lung; Macrophages; Male; Nerve Tissue Proteins; Potassium Channels, Tandem Pore Domain; Protein Kinase Inhibitors; Pyrroles; Rats, Nude; Rodentia; Stroke Volume; Tomography, Emission-Computed, Single-Photon	2021
Inhibition of Glucose-6-Phosphate Dehydrogenase Activity Attenuates Right Ventricle Pressure and Hypertrophy Elicited by VEGFR Inhibitor + Hypoxia. The Journal of pharmacology and experimental therapeutics, 2021, Volume: 377, Issue:2 Topics: Animals; Blood Pressure; Cardiomegaly; Cell Hypoxia; Cells, Cultured; DNA Methylation; Enzyme Inhibitors; Female; Glucosephosphate Dehydrogenase; Humans; Hypertension, Pulmonary; Indoles; Male; Mice; Mice, Inbred C57BL; Myocardium; Myocytes, Smooth Muscle; Pyrroles; Ventricular Function, Right	2021
Preclinical Investigation of Trifluoperazine as a Novel Therapeutic Agent for the Treatment of Pulmonary Arterial Hypertension. International journal of molecular sciences, 2021, Mar-13, Volume: 22, Issue:6 Topics: Animals; Antipsychotic Agents; Cardiovascular Agents; Cell Proliferation; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Repositioning; Female; Forkhead Box Protein O3; Gene Expression Regulation; Hemodynamics; Humans; Hypertension, Pulmonary; Hypoxia; Indoles; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Primary Cell Culture; Proto-Oncogene Proteins c-akt; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; Survivin; Trifluoperazine	2021
Deficiency of Axl aggravates pulmonary arterial hypertension via BMPR2. Communications biology, 2021, 08-24, Volume: 4, Issue:1 Topics: Angiogenesis Inhibitors; Animals; Bone Morphogenetic Protein Receptors, Type II; Gene Expression Regulation; Indoles; Male; Monocrotaline; Pulmonary Arterial Hypertension; Pyrroles; Rats, Inbred WKY; Rats, Sprague-Dawley; Receptor Protein-Tyrosine Kinases	2021
Treprostinil palmitil inhibits the hemodynamic and histopathological changes in the pulmonary vasculature and heart in an animal model of pulmonary arterial hypertension. European journal of pharmacology, 2022, Feb-05, Volume: 916 Topics: Administration, Inhalation; Administration, Oral; Animals; Collagen; Disease Models, Animal; Epoprostenol; Heart; Hemodynamics; Hypoxia; Indoles; Male; Myocardium; Phosphodiesterase 5 Inhibitors; Pulmonary Arterial Hypertension; Pulmonary Artery; Pyrroles; Rats, Sprague-Dawley; Sildenafil Citrate; Vascular Remodeling; Vasodilator Agents	2022
Role of IL-33 receptor (ST2) deletion in diaphragm contractile and mitochondrial function in the Sugen5416/hypoxia model of pulmonary hypertension. Respiratory physiology & neurobiology, 2022, Volume: 295 Topics: Animals; Diaphragm; Disease Models, Animal; Hypertension, Pulmonary; Hypoxia; Indoles; Interleukin-1 Receptor-Like 1 Protein; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mitochondria; Mitochondrial Diseases; Muscle Contraction; Protein Kinase Inhibitors; Pulmonary Arterial Hypertension; Pyrroles	2022
Riociguat can ameliorate bronchopulmonary dysplasia in the SU5416 induced rat experimental model. Experimental lung research, 2021, Volume: 47, Issue:8 Topics: Animals; Animals, Newborn; Bronchopulmonary Dysplasia; Disease Models, Animal; Humans; Hyperoxia; Indoles; Infant, Newborn; Lung; Models, Theoretical; Pyrazoles; Pyrimidines; Pyrroles; Rats	2021
Right predominant electrical remodeling in a pure model of pulmonary hypertension promotes reentrant arrhythmias. Heart rhythm, 2022, Volume: 19, Issue:1 Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Disease Models, Animal; Hypertension, Pulmonary; Indoles; Magnetic Resonance Imaging; Male; Pneumonectomy; Pyrroles; Rats; Rats, Sprague-Dawley; Thoracotomy; Ventricular Remodeling	2022
Andrographolide Attenuates Established Pulmonary Hypertension via Rescue of Vascular Remodeling. Biomolecules, 2021, 11-30, Volume: 11, Issue:12 Topics: Animals; Anti-Inflammatory Agents; Cell Movement; Cell Proliferation; Cell Survival; Cells, Cultured; Disease Models, Animal; Diterpenes; Female; Gene Expression Regulation; Humans; Hypertension, Pulmonary; Indoles; Male; Mice; Primary Cell Culture; Pyrroles; Signal Transduction; Vascular Remodeling	2021
The Isoquinoline-Sulfonamide Compound H-1337 Attenuates SU5416/Hypoxia-Induced Pulmonary Arterial Hypertension in Rats. Cells, 2021, 12-27, Volume: 11, Issue:1 Topics: Animals; Cell Proliferation; Heart Ventricles; Humans; Hypoxia; Indoles; Isoquinolines; Lung; Male; Metabolome; Myosin Light Chains; Phosphorylation; Proto-Oncogene Proteins c-akt; Pulmonary Arterial Hypertension; Pyrroles; Rats, Sprague-Dawley; Sulfonamides; TOR Serine-Threonine Kinases; Vascular Remodeling	2021
Mineralocorticoid receptor antagonist treatment of established pulmonary arterial hypertension improves interventricular dependence in the SU5416-hypoxia rat model. American journal of physiology. Lung cellular and molecular physiology, 2022, 03-01, Volume: 322, Issue:3 Topics: Animals; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Humans; Hypertension, Pulmonary; Hypoxia; Indoles; Mineralocorticoid Receptor Antagonists; Pulmonary Arterial Hypertension; Pyrroles; Rats; Ventricular Dysfunction, Right	2022