Compounds > pyrroles
Page last updated: 2024-08-18

pyrroles and retrorsine

pyrroles has been researched along with retrorsine in 12 studies

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19901 (8.33)18.7374
1990's5 (41.67)18.2507
2000's0 (0.00)29.6817
2010's1 (8.33)24.3611
2020's5 (41.67)2.80

Authors

AuthorsStudies
White, IN1
Chu, PS; Segall, HJ1
Cooper, RA; Huxtable, RJ; Yan, CC1
Chu, PS; Lamé, MW; Segall, HJ1
Eckert, A; Roeder, E; Wiedenfeld, H1
Cui, YY; Hawes, EM; Lin, G1
Fu, PP; Lin, G; Lu, Y; Ma, J; Song, Z; Ye, Y1
Fu, PP; He, Y; Lin, G; Ma, J; Song, Z1
Cheng, T; Li, N; Li, W; Lin, G; Wang, H; Yang, X; Zhang, F; Zheng, J1
Fu, PP; He, X; He, Y; Jia, W; Lin, G; Ma, J; Xia, Q; Zhang, C; Zhang, W; Zhu, L; Zhuge, Y1
Fu, PP; He, Y; Lin, G; Xia, Q; Xue, J; Zhu, L1
Lai, X; Li, J; Li, W; Li, X; Zheng, J; Zhou, M1

Other Studies

12 other study(ies) available for pyrroles and retrorsine

ArticleYear
Excretion of pyrrolic metabolites in the bile of rats given the pyrrolizidine alkaloid retrorsine or the bis-N-ethylcarbamate of synthanecine A.
    Chemico-biological interactions, 1977, Volume: 16, Issue:2

    Topics: Animals; Bile; Chromatography, Thin Layer; Kinetics; Male; Pyrroles; Pyrrolizidine Alkaloids; Rats

1977
Species difference in the urinary excretion of isatinecic acid from the pyrrolizidine alkaloid retrorsine.
    Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1991, Volume: 100, Issue:3

    Topics: Animals; Chromatography, Gas; Chromatography, High Pressure Liquid; Cricetinae; Dicarboxylic Acids; Guinea Pigs; Male; Mammals; Mesocricetus; Mice; Mice, Inbred BALB C; Molecular Structure; Oxides; Pyrroles; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Species Specificity

1991
The comparative metabolism of the four pyrrolizidine alkaloids, seneciphylline, retrorsine, monocrotaline, and trichodesmine in the isolated, perfused rat liver.
    Toxicology and applied pharmacology, 1995, Volume: 133, Issue:2

    Topics: Alkaloids; Analysis of Variance; Animals; Antineoplastic Agents, Phytogenic; Bile; Glutathione; Lethal Dose 50; Liver; Male; Monocrotaline; Perfusion; Pyrroles; Pyrrolizidine Alkaloids; Rats; Rats, Sprague-Dawley; Spectrophotometry, Ultraviolet; Structure-Activity Relationship

1995
In vivo metabolism of retrorsine and retrorsine-N-oxide.
    Archives of toxicology, 1993, Volume: 67, Issue:1

    Topics: Animals; Chromatography, Gas; Chromatography, High Pressure Liquid; Dicarboxylic Acids; Male; Phenobarbital; Plants, Toxic; Pyrroles; Pyrrolizidine Alkaloids; Rats; Rats, Sprague-Dawley; Senecio; Tritolyl Phosphates

1993
Pyrrolizidine alkaloids from Gynura divaricata.
    Planta medica, 1996, Volume: 62, Issue:4

    Topics: Alkaloids; Antineoplastic Agents, Phytogenic; Hong Kong; Medicine, Chinese Traditional; Molecular Structure; Plants, Medicinal; Pyrroles; Pyrrolizidine Alkaloids

1996
Microsomal formation of a pyrrolic alcohol glutathione conjugate of clivorine. Firm evidence for the formation of a pyrrolic metabolite of an otonecine-type pyrrolizidine alkaloid.
    Drug metabolism and disposition: the biological fate of chemicals, 1998, Volume: 26, Issue:2

    Topics: Alcohols; Animals; Chromatography, High Pressure Liquid; Glutathione; Male; Mass Spectrometry; Microsomes, Liver; Molecular Structure; Pyrroles; Pyrrolizidine Alkaloids; Rats; Rats, Sprague-Dawley

1998
The role of formation of pyrrole-ATP synthase subunit beta adduct in pyrrolizidine alkaloid-induced hepatotoxicity.
    Archives of toxicology, 2018, Volume: 92, Issue:11

    Topics: Adenosine Triphosphate; Animals; Apoptosis; Cells, Cultured; Hepatocytes; Humans; Liver; Male; Mitochondria; Mitochondrial Proton-Translocating ATPases; Pyrroles; Pyrrolizidine Alkaloids; Rats; Rats, Sprague-Dawley

2018
Pulmonary toxicity is a common phenomenon of toxic pyrrolizidine alkaloids.
    Journal of environmental science and health. Part C, Toxicology and carcinogenesis, 2020, Volume: 38, Issue:2

    Topics: Activation, Metabolic; Animals; Drug-Related Side Effects and Adverse Reactions; Drugs, Chinese Herbal; Liver; Lung; Monocrotaline; Proteins; Pyrroles; Pyrrolizidine Alkaloids; Rats

2020
Antibody-based detection of lysine modification of hepatic protein in mice treated with retrorsine.
    Journal of environmental science and health. Part C, Toxicology and carcinogenesis, 2020, Volume: 38, Issue:4

    Topics: Animals; Carcinogens; Immunologic Tests; Liver; Lysine; Mice; Proteins; Pyrroles; Pyrrolizidine Alkaloids

2020
Developing urinary pyrrole-amino acid adducts as non-invasive biomarkers for identifying pyrrolizidine alkaloids-induced liver injury in human.
    Archives of toxicology, 2021, Volume: 95, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Amino Acids; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Female; Humans; Male; Middle Aged; Pyrroles; Pyrrolizidine Alkaloids; Rats; Rats, Sprague-Dawley; Time Factors

2021
Correlation Investigation between Pyrrole-DNA and Pyrrole-Protein Adducts in Male ICR Mice Exposed to Retrorsine, a Hepatotoxic Pyrrolizidine Alkaloid.
    Toxins, 2022, 05-28, Volume: 14, Issue:6

    Topics: Animals; Carcinogens; DNA; DNA Adducts; Liver; Male; Mice; Mice, Inbred ICR; Proteins; Pyrroles; Pyrrolizidine Alkaloids

2022
Evaluating and predicting the correlations of hepatic concentration and pyrrole-protein adduction with hepatotoxicity induced by retrorsine based on pharmacokinetic/pharmacodynamic model.
    Toxicology letters, 2023, Jan-15, Volume: 373

    Topics: Animals; Chemical and Drug Induced Liver Injury; Liver; Mice; Proteins; Pyrroles; Pyrrolizidine Alkaloids

2023