pyrroles has been researched along with quinoxalines in 126 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (7.14) | 18.7374 |
| 1990's | 10 (7.94) | 18.2507 |
| 2000's | 39 (30.95) | 29.6817 |
| 2010's | 49 (38.89) | 24.3611 |
| 2020's | 19 (15.08) | 2.80 |
| Authors | Studies |
|---|---|
| De Martino, G; Massa, S; Scalzo, M | 1 |
| Halliday, CA; Jones, BJ; Skingle, M; Tyers, MB; Walsh, DM; Wise, H | 1 |
| Doussau, MP; Gautier, P; Giudicelli, JF; Mulder, P; Richer, C | 1 |
| Ager, IR; Barnes, AC; Danswan, GW; Hairsine, PW; Kay, DP; Kennewell, PD; Matharu, SS; Miller, P; Robson, P; Rowlands, DA | 1 |
| Drew, HR; Low, CM; Waring, MJ | 1 |
| Portugal, J; Waring, MJ | 1 |
| Neurath, G | 1 |
| Khan, MA | 1 |
| Artico, M; Chimenti, F; Dolfini, E; Giuliano, R; Morasca, L; Vomero, S | 1 |
| Bachmann, G; Eiden, F | 1 |
| Abou-Gharbia, M; Freed, ME; McCaully, RJ; Silver, PJ; Wendt, RL | 1 |
| Greenberg, DA; Koretz, B; Lustig, HS; von B Ahern, K; Wang, N | 1 |
| Angel, I; Grosset, A; Langer, SZ; Perrault, G; Schoemaker, H | 1 |
| Colpaert, F; Marien, M; Tellez, S | 1 |
| Polte, T; Schröder, H | 1 |
| Behl, B; Gross, G; Hofmann, HP; Höger, T; Lehmann, H; Lemaire, HG; Löscher, W; Lubisch, W; Seemann, D; Teschendorf, HJ | 1 |
| Drejer, J; Gouliaev, AH; Jensen, LH; Mathiesen, C; Moller, A; Nielsen, EO; Varming, T; Wätjen, F | 1 |
| Ezure, Y; Hasegawa, H; Kawano, K; Matsukawa, H; Morizono, D; Naito, A; Naito, K; Oguma, T; Ohtake, Y; Tanaka, Y; Taniguchi, M; Tsuriya, Y | 1 |
| Butini, S; Caccia, S; Cagnotto, A; Campiani, G; Cervo, L; Dalla Valle, F; Fracasso, C; Gemma, S; Goegan, M; Greco, G; Hamon, M; Mennini, T; Morelli, E; Nacci, V; Novellino, E | 1 |
| Feijge, MA; Heemskerk, JW; Keularts, IM; van Gorp, RM; Vuist, WM | 1 |
| Kawahara, H; Kawahara, Y; Westerink, BH | 1 |
| Ezure, Y; Fukaya, AY; Hasegaw, H; Koike, K; Kurasawa, T; Matsukawa, H; Naito, A; Naito, K; Oguma, T; Ohtake, Y; Shigenobu, K; Tanaka, H; Tsuriya, Y | 1 |
| Fukao, K; Fukunaga, K; Ishibashi, A; Kobayashi, S; Otsuka, M; Seino, K; Takada, Y; Taniguchi, H; Todoroki, T; Tokuhara, N; Yamauchi, T; Yuzawa, K | 1 |
| Dick, JM; Lefebvre, RA | 1 |
| Béïque, J; Blier, P; de Montigny, C; Debonnel, G | 1 |
| Ezure, Y; Hasegawa, H; Koike, K; Kurasawa, T; Matsukawa, H; Naito, A; Ohtake, Y; Shigenobu, K; Tsuriya, Y | 1 |
| Ezure, Y; Hasegawa, H; Koike, K; Kurasawa, T; Matsukawa, H; Naito, A; Ohtake, Y; Shigenobu, K | 1 |
| Blier, P; Hen, R; Richer, M | 1 |
| Allescher, HD; Folmer, R; Kurjak, M; Schusdziarra, V; Storr, M | 1 |
| Furuta, H; Lynch, VM; Maeda, H; Mizuno, T; Sessler, JL | 1 |
| Amtage, F; Birthelmer, A; Cassel, JC; Ehret, A; Förster, S; Jackisch, R; Jeltsch, H; Lehmann, O | 1 |
| Barraja, P; Beall, HD; Bunderson, M; Moody, CJ; Newsome, JJ; Swann, E; Tooke, JE; Whatmore, JL | 1 |
| Iida, H; Inoue, N; Ishida, H; Ishikawa, Y; Yuan, Z | 1 |
| Birthelmer, A; Cassel, JC; Jackisch, R; Stemmelin, J | 1 |
| Birthelmer, A; Cassel, JC; Jackisch, R; Lazaris, A; Schweizer, T | 1 |
| Alleca, S; Busonera, B; Corona, P; La Colla, P; Loddo, R; Loriga, M; Mascia, V; Paglietti, G | 1 |
| Katayev, E; Lynch, VM; Pantos, GD; Sessler, JL | 1 |
| Bartolini, A; Galeotti, N; Ghelardini, C; Gualtieri, F; Manetti, D; Pittaluga, A; Pugliese, AM; Romanelli, MN | 1 |
| De Godoy, M; Li, F; Rattan, S | 1 |
| Dallemagne, P; Déprez-Poulain, R; Forfar-Bares, I; Grellier, P; Guillon, J; Jarry, C; Labaied, M; Léger, JM; Lemaître, N; Péhourcq, F; Rochette, J; Sergheraert, C; Sonnet, P | 1 |
| Akasu, T; Hasuo, H; Matsuoka, T | 1 |
| Blackburn-Munro, G; Bomholt, SF; Erichsen, HK | 1 |
| Barnes, NY; Parent, AT; Sisodia, SS; Taniguchi, Y; Thinakaran, G | 1 |
| Bramley, JR; Dudek, FE; Pickard, GE; Sollars, PJ | 1 |
| Amssoms, KI; Boonants, PM; Daeyaert, FF; Dierynck, I; Hertogs, K; Hu, L; Pille, GM; Surleraux, DL; Verschueren, WG; Wigerinck, PB | 1 |
| Chen, MS; Lin, CA; Lin, SC; Sun, SS; Wu, CY | 1 |
| Abraham, NG; Bolognesi, M; Di Pascoli, M; Rodella, L; Sacerdoti, D; Turkseven, S | 1 |
| Durdaği, S; Karalti, O; Salzner, U | 1 |
| Gajhede, M; Greenwood, JR; Kasper, C; Kastrup, JS; Kristensen, AS; Liljefors, T; Mirza, O; Olsen, L; Pickering, DS; Schousboe, A; Sigurskjold, BW; Wätjen, F | 1 |
| Jackisch, R; Riegert, C; Rothmaier, AK; Rutz, S | 1 |
| Hoang, H; Ireland, CM; LaBarbera, DV; Mohammed, KA; Skibo, EB | 1 |
| Bousquet, P; Feldman, J; Fellmann, L; Greney, H; Urosevic, D; Yoro Sy, G | 1 |
| Ma, D; Yuan, Q | 1 |
| Bag, S; Degani, MS; Tawari, NR | 1 |
| Desplat, V; Fabre, SB; Forfar, I; Grellier, P; Guillon, J; Jarry, C; Millet, P; Moreau, S; Mouray, E; Parzy, D; Sinou, V | 1 |
| Begorre, MA; Brajot, S; Desplat, V; Fabre, SB; Geneste, A; Guillon, J; Jarry, C; Massip, S; Mossalayi, D; Thiolat, D | 1 |
| Borrelli, G; Budriesi, R; Butini, S; Caccia, S; Cagnotto, A; Campiani, G; Catalanotti, B; Chiarini, A; Coccone, SS; Colovic, M; Fattorusso, C; Fiorini, I; Fracasso, C; Gemma, S; Hamon, M; Ioan, P; Mennini, T; Morelli, E; Nacci, V; Novellino, E; Persico, M; Ros, S | 1 |
| Borrelli, G; Brindisi, M; Budriesi, R; Butini, S; Caccia, S; Cagnotto, A; Campiani, G; Chiarini, A; Fiorini, I; Fracasso, C; Gemma, S; Hamon, M; Ioan, P; Mennini, T; Morelli, E; Novellino, E | 1 |
| Brotherhood, PR; Crossley, MJ; Kadish, KM; McDonald, JA; Ou, Z; Sintic, M; Sintic, PJ; Zhu, W | 1 |
| Desplat, V; Fabre, SB; Gay, A; Godde, F; Guillon, J; Jarry, C; Macky, G; Massip, S; Moreau, S; Mossalayi, D; Thiolat, D | 1 |
| Kavthe, RD; Patil, NT; Shinde, VS; Sridhar, B | 1 |
| Baimoukhametova, DV; Bains, JS; Kuzmiski, JB; Marty, V | 1 |
| Ahanger, AA; Choudhury, S; Kandasamy, K; Mishra, SK; More, AS; Parida, S; Prawez, S; Singh, TU | 1 |
| Belisle-Fabre, S; Déléris, G; Desplat, V; Forfar, I; Gosmann, G; Grellier, P; Guillon, J; Jarry, C; Le-Naour, A; Léger, JM; Moreau, S; Mouray, E; Mullié, C; Pinaud, N; Ravanello, F; Sonnet, P | 1 |
| Jiang, H; Lin, D; Liu, G; Liu, H; Wang, J; Zhang, L; Zhou, Y | 1 |
| Fu, Z; Fukuzumi, S; Kadish, KM; Karnas, E; Mase, K; Ohkubo, K; Sessler, JL | 1 |
| Aston-Jones, G; Smith, RJ | 1 |
| Affolter, M; Belting, HG; Blondelle, J; Epstein, JA; Flaherty, KM; Gay, CM; Herwig, L; Krudewig, A; Means, PC; Singh, MK; Torres-Vázquez, J; Zygmunt, T | 1 |
| Huang, A; Liu, F; Liu, Y; Ma, C; Zhan, C | 1 |
| Pereira, Mde F; Thiéry, V | 1 |
| Deora, GS; Kishore, R; Meda, CL; Nakhi, A; Pal, M; Parsa, KV; Rahman, MS | 1 |
| Ammermann, S; du Mont, WW; Hrib, C; Johannes, HH; Jones, PG; Kowalsky, W | 1 |
| Huang, A; Ma, C | 1 |
| Abonía, R; Castillo, JC; Cobo, J; Glidewell, C | 1 |
| Alvarez, L; Baratin, S; Bollacke, A; Desplat, V; Guillon, J; Jose, J; Le Borgne, M; Marchivie, M; Moreau, S; Pecci, A; Pinaud, N; Rimbault, C; Roche, S; Savrimoutou, S | 1 |
| Bartholomew, P; Elwell, M; Radi, Z; Vogel, WM | 1 |
| Fang, G; Liu, H; Pan, M; Qian, H; Wang, S; Wang, X; Yang, Y | 1 |
| Adibi-Sedeh, S; Karimian, S; Sanaeishoar, T | 1 |
| Chen, MW; Chen, ZP; Guo, RN; Zhou, YG | 1 |
| Fraser, K | 1 |
| Caflisch, A; Dong, J; Frugier, E; Lafleur, K; Nevado, C; Unzue, A; Zhao, H | 1 |
| Booth, R; Kim, H | 1 |
| Archana, S; Deora, GS; Kolli, SK; Kulkarni, P; Medisetti, R; Nakhi, A; Pal, M; Ramesh Raju, R; Saridena, M; Yellanki, S | 1 |
| Fan, C; Hu, X; Jin, C; Liu, Y; Lu, X; Tao, H; Wang, X; Zhu, Y | 1 |
| Anderson, RF; Denny, WA; Hay, MP; Marshall, AJ; Reynisson, J; Yadav, P | 1 |
| Bae, M; He, Z; Jamison, TF; Wu, J | 1 |
| An, D; Antilla, JC; Fan, YS; Jiang, YJ; Sha, D; Zhang, S | 1 |
| Chanda, K; Dhole, S; Maiti, B; Selvaraju, M; Sun, CM | 1 |
| Duan, T; Liu, H; Ma, C; Xie, C; Zhang, Z | 1 |
| Li, J; Liu, Q; Liu, T; Ma, N; Zhang, G; Zhang, Z | 1 |
| Hao, E; Jiao, L; Li, T; Mu, X; Sheng, W; Wang, J; Wei, Y; Yu, C | 1 |
| Hu, X; Jin, C; Liu, Y; Lu, X; Tao, H; Wang, X; Zhu, Y | 1 |
| Cheng, TJ; Cheng, YS; Dangate, P; Huang, WI; Lee, CH; Lin, MI; Lin, OA; Su, BH; Sun, CM; Tseng, YJ; Wang, ST; Wang, SY; Wu, WC | 1 |
| Bouchard, LS; Guo, Q; Jiang, W; Liu, M; Luo, Q; Zeng, Q; Zhang, X; Zhou, X | 1 |
| Aubé, J; Bohn, LM; Frankowski, KJ; Lovell, KM; Scarry, SM | 1 |
| Chua, KF; Kambach, C; Li, TM; Mai, A; Meleshin, M; Rotili, D; Schutkowski, M; Steegborn, C; You, W | 1 |
| Agnamey, P; Azas, N; Bentzinger, G; Cohen, A; Dassonville-Klimpt, A; Guillon, J; Hutter, S; Jonet, A; Moreau, S; Mullie, C; Savrimoutou, S; Schneider, J; Sonnet, P; Taudon, N | 1 |
| Chen, Y; Liu, H; Luo, W; Ma, C; Zhang, C; Zhou, F | 1 |
| Mikami, Y; Murofushi, T; Suzuki, N; Tsuda, H; Yamaguchi, Y | 1 |
| Haniuda, M; Hosokawa, Y; Hyodo, T; Karnan, S; Konishi, H; Ota, A; Tsuzuki, S; Wahiduzzaman, M; Yamaji, M | 1 |
| Bae, H; Bang, H; Choi, J; Kim, JH; Kim, T; Kim, YW; Ko, JH; Lee, D; Lim, I | 1 |
| An, Q; Deng, Y; Liu, P; Luo, Y; Sang, Z; Tang, Y; Wang, T; Yang, T; Yang, Y; Zhang, T | 1 |
| Chandrasekaran, G; Kumar, D; Kumar, T; Mahobiya, A; Parida, S; Rungsung, S; Singh, TU | 1 |
| Biroccio, A; Ciriolo, MR; Del Bufalo, D; Di Leo, L; Iachettini, S; Leonetti, C; Lucidi, A; Mai, A; Rizzo, A; Rotili, D; Salvati, E; Steegborn, C; Trisciuoglio, D; Zizza, P | 1 |
| Budke, B; Connell, PP; Kozikowski, AP; Miles, K; Tueckmantel, W | 1 |
| Bjune, K; Naderi, S; Wierød, L | 1 |
| Furukawa, S; Ishikawa, T; Kikuchi, H; Ooka, A; Saito, SY; Yamaguchi, M | 1 |
| Bai, X; Fang, G; Hu, X; Liu, M; Wang, S; Zhang, B | 1 |
| Bowen, JP; Güner, OF; Matesic, DF; Uko, NE | 1 |
| Abbaspour, S; Bakherad, M; Fakharian, M; Keivanloo, A; Lashkari, S | 1 |
| Babar, DA; Chopra, S; Kalari, S; Karale, UB; Kaul, G; Makane, VB; Misra, S; Rekha, EM; Rode, HB; Shukla, M; Sriram, D; Vamshi Krishna, E | 1 |
| Alajarín, R; de Pascual-Teresa, B; Di Geronimo, B; García-Marín, J; Griera, M; Mendicuti, F; Rodríguez-Puyol, D; Rodríguez-Puyol, M; Sánchez-Alonso, P; Vaquero, JJ | 1 |
| Babiker, HM; Chandana, SR; Mahadevan, D | 1 |
| Bossaer, JB; Weaver, A | 1 |
| Birrer, MJ; Chi, RA; Leaner, VD; van der Watt, P; Wei, W | 1 |
| Al-Obaidy, KI; Cheng, L | 1 |
| Abu-Hashem, AA; Al-Hussain, SA; Zaki, MEA | 1 |
| Hubert, P; Loriot, Y; Selmani, Z; Thiery-Vuillemin, A | 1 |
| Alajarín, R; García-Marín, J; Griera, M; Rodríguez-Puyol, D; Rodríguez-Puyol, M; Vaquero, JJ | 1 |
| Alajarín, R; García-Marín, J; Griera, M; Rodríguez-Puyol, D; Rodríguez-Puyol, M; Sánchez-Alonso, P; Vaquero, JJ | 1 |
| Javle, M; King, G | 1 |
| Alajarín, R; de Lucio, H; Gago, F; García-Marín, J; García-Soriano, JC; Jiménez-Ruiz, A; Sánchez-Alonso, P; Toro, MÁ; Vaquero, JJ | 1 |
| Basta, MD; Paulson, H; Walker, JL | 1 |
| Galenko, EE; Khlebnikov, AF; Novikov, MS; Puzyk, AM | 1 |
| Fang, W; Geng, M; Huang, M; Kuang, J; Ma, Y; Miao, M | 1 |
| Amin, T; Bhagat, M; Chhabra, S; Goswami, A; Kapoor, KK; Kotwal, P; Mir, KB; Nandi, U; Parkesh, R; Sharma, RP; Slathia, N; Tsering, D | 1 |
8 review(s) available for pyrroles and quinoxalines
| Article | Year |
|---|---|
[Nitrogen compounds of tobacco smoke].
Topics: Acridines; Alkaloids; Alkanes; Amines; Amino Acids; Aniline Compounds; Carbazoles; Cyanates; Indoles; Isoquinolines; Ketones; Niacinamide; Nicotiana; Nicotine; Nicotinic Acids; Nitriles; Nitrites; Nitrosamines; Piperidines; Plants, Toxic; Pyrazines; Pyridines; Pyrroles; Pyrrolidines; Quinolines; Quinoxalines; Smoking | 1969 |
Recent progress in biological activities and synthetic methodologies of pyrroloquinoxalines.
Topics: Anti-HIV Agents; Antimalarials; Antineoplastic Agents; Catalysis; Cell Survival; HIV-1; Humans; Metals; Plasmodium falciparum; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-akt; Pyrroles; Quinoxalines | 2013 |
Comparative pathophysiology, toxicology, and human cancer risk assessment of pharmaceutical-induced hibernoma.
Topics: Animals; Benzazepines; Carcinogenicity Tests; Disease Models, Animal; Humans; Hydromorphone; Lipoma; Mutagenicity Tests; Neoplasms; Phentolamine; Piperidines; Pyrimidines; Pyrroles; Quinoxalines; Rats; Risk Assessment; Varenicline | 2013 |
Akt Pathway Inhibitors.
Topics: Antineoplastic Agents; Benzylamines; Cell Line, Tumor; Diamines; Drug Design; Heterocyclic Compounds, 3-Ring; Humans; Molecular Docking Simulation; Phosphatidylinositol 3-Kinases; Phospholipids; Piperazines; Protein Conformation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrazoles; Pyrimidines; Pyrroles; Quinoxalines; Signal Transduction; Structure-Activity Relationship; Sulfonamides; Thiadiazoles; Thiophenes | 2020 |
Clinical complexity of utilizing FGFR inhibitors in cancer therapeutics.
Topics: Animals; Antineoplastic Agents; Fibroblast Growth Factors; Humans; Molecular Targeted Therapy; Morpholines; Neoplasms; Pyrazoles; Pyrimidines; Pyrroles; Quinoxalines; Receptors, Fibroblast Growth Factor | 2020 |
Fibroblast growth factor receptor (FGFR) inhibitors: A review of a novel therapeutic class.
Topics: Bile Duct Neoplasms; Carcinoma, Transitional Cell; Cholangiocarcinoma; Clinical Trials as Topic; Humans; Morpholines; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; Pyrroles; Quinoxalines; Receptor, Fibroblast Growth Factor, Type 2; Receptor, Fibroblast Growth Factor, Type 3 | 2021 |
Fibroblast growth factor receptor (
Topics: Antineoplastic Agents; Biomarkers, Tumor; Carcinoma; Exons; Gene Amplification; Gene Fusion; Genetic Predisposition to Disease; Humans; Molecular Targeted Therapy; Mutation, Missense; Phenotype; Phenylurea Compounds; Piperazines; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; Pyrroles; Quinoxalines; Receptor, Fibroblast Growth Factor, Type 3; Thiophenes; Urinary Bladder Neoplasms; Urothelium | 2021 |
FGFR Inhibitors: Clinical Activity and Development in the Treatment of Cholangiocarcinoma.
Topics: Aniline Compounds; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cholangiocarcinoma; Clinical Trials as Topic; Humans; Morpholines; Mutation; Phenylurea Compounds; Precision Medicine; Pyrazoles; Pyrimidines; Pyrroles; Quinazolines; Quinoxalines; Receptors, Fibroblast Growth Factor; Signal Transduction | 2021 |
118 other study(ies) available for pyrroles and quinoxalines
| Article | Year |
|---|---|
[Research on substances with antiblastic activity. LVIII. Synthesis and antineoplastic activity of derivatives of pyrrolo-(1,2-a)quinoxaline].
Topics: Animals; Antineoplastic Agents; Chemistry, Pharmaceutical; Drug Evaluation, Preclinical; Leukemia L1210; Mice; Pyrroles; Quinoxalines | 1975 |
The pharmacology of fluparoxan: a selective alpha 2-adrenoceptor antagonist.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics; Animals; Aorta; Body Temperature; Brimonidine Tartrate; Clonidine; Guinea Pigs; Heart Rate; Ileum; In Vitro Techniques; Male; Muscle, Smooth; Norepinephrine; Piperoxan; Postural Balance; Pyrroles; Quinoxalines; Rabbits; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Dopamine; Receptors, Histamine; Receptors, Muscarinic; Receptors, Serotonin; Vas Deferens | 1991 |
Systemic and regional haemodynamic interactions between K+ channel openers and the sympathetic nervous system in the pithed SHR.
Topics: Animals; Benzopyrans; Brimonidine Tartrate; Cromakalim; Decerebrate State; Dihydropyridines; Heart Rate; Hemodynamics; Imidazoles; Male; Potassium Channels; Pyrroles; Quinoxalines; Rats; Rats, Inbred SHR; Regional Blood Flow; Sympathetic Nervous System; Vascular Resistance | 1990 |
Synthesis and oral antiallergic activity of carboxylic acids derived from imidazo[2,1-c][1,4]benzoxazines, imidazo[1,2-a]quinolines, imidazo[1,2-a]quinoxalines, imidazo[1,2-a]quinoxalinones, pyrrolo[1,2-a]quinoxalinones, pyrrolo[2,3-a]quinoxalinones, and
Topics: Animals; Carboxylic Acids; Cromolyn Sodium; Histamine H1 Antagonists; Hypersensitivity; Imidazoles; Oxazines; Passive Cutaneous Anaphylaxis; Pyrroles; Quinoxalines; Rats; Structure-Activity Relationship; Thiazoles | 1988 |
Echinomycin and distamycin induce rotation of nucleosome core DNA.
Topics: Animals; Base Sequence; Chickens; Deoxyribonuclease I; Distamycins; DNA; Echinomycin; In Vitro Techniques; Nucleic Acid Conformation; Nucleosomes; Plasmids; Pyrroles; Quinoxalines | 1986 |
Interaction of nucleosome core particles with distamycin and echinomycin: analysis of the effect of DNA sequences.
Topics: Animals; Base Sequence; Chickens; Deoxyribonuclease I; Distamycins; DNA; Echinomycin; Erythrocytes; Histones; Nucleosomes; Plasmids; Pyrroles; Quinoxalines; Xenopus | 1987 |
4-oxopyranoazoles and 4-oxopyranoazines.
Topics: Azoles; Benzene Derivatives; Chromones; Heterocyclic Compounds; Naphthols; Oxazoles; Phenanthridines; Pyrans; Pyrazoles; Pyridines; Pyrroles; Quinolines; Quinolizines; Quinoxalines; Structure-Activity Relationship | 1972 |
[Research on antineoplastic substances. LI. Derivatives of benzo(f)-pyrrolo-(1,2-a)-quinoxaline and naphtho-(2,1-e)-pyrrolo-(2,1-c)-as-triazine: synthesis and cytostatic and cytotoxic activity].
Topics: Antineoplastic Agents; Carcinoma; Carcinoma, Squamous Cell; Cell Line; Cells, Cultured; Culture Media; Humans; Mouth Neoplasms; Nasopharyngeal Neoplasms; Pyrroles; Quinoxalines; Structure-Activity Relationship; Triazines | 1973 |
[Pyrrolo (1,2-a) quinoxalines (author's transl)].
Topics: Anhydrides; Formates; Magnetic Resonance Spectroscopy; Pyrroles; Quinoxalines | 1973 |
Tetrahydropyrrolo[1,2-a]quinoxalines and tetrahydropyrrolo[1,2-a]pyrido[3,2-a]pyrazines: vascular smooth muscle relaxants and antihypertensive agents.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Chemical Phenomena; Chemistry; Female; Indicators and Reagents; Magnetic Resonance Spectroscopy; Mass Spectrometry; Muscle Relaxation; Muscle, Smooth, Vascular; Neuromuscular Depolarizing Agents; Optical Rotation; Pyrazines; Pyrroles; Quinoxalines; Rabbits; Spectrophotometry, Infrared; Structure-Activity Relationship | 1984 |
Pre- and post-synaptic modulators of excitatory neurotransmission: comparative effects on hypoxia/hypoglycemia in cortical cultures.
Topics: Animals; Aspartic Acid; Benzopyrans; Calcium Channel Blockers; Cell Hypoxia; Cells, Cultured; Cerebral Cortex; Cromakalim; Diazoxide; Embryo, Mammalian; Glutamates; Hypoglycemia; Kainic Acid; Kinetics; L-Lactate Dehydrogenase; Neurons; Potassium Channels; Pyrroles; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission; Time Factors | 1994 |
In vivo pharmacological profile of SL 84.0418, a new selective, peripherally active alpha 2-adrenoceptor antagonist.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Glucose; Blood Pressure; Brimonidine Tartrate; Clonidine; Decerebrate State; Dioxanes; Epinephrine; Heart Rate; Hyperglycemia; Idazoxan; Indoles; Male; Mice; Motor Activity; Norepinephrine; Peripheral Nerves; Prazosin; Pyrroles; Quinoxalines; Rats; Rats, Sprague-Dawley; Stereoisomerism; Vasoconstriction | 1993 |
Acetylcholine release in the rat prefrontal cortex in vivo: modulation by alpha 2-adrenoceptor agonists and antagonists.
Topics: Acetylcholine; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Clonidine; Guanabenz; Idazoxan; Imidazoles; Male; Microdialysis; Piperoxan; Prefrontal Cortex; Pyrroles; Quinoxalines; Rats; Rats, Sprague-Dawley | 1997 |
Cyclic AMP mediates endothelial protection by nitric oxide.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclase Inhibitors; Alkaloids; Animals; Carbazoles; Cattle; Cell Line; Cell Survival; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic N-Oxides; Dideoxyadenosine; Endothelium, Vascular; Enzyme Inhibitors; Free Radical Scavengers; Imidazoles; Indoles; Kinetics; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Penicillamine; Pulmonary Artery; Pyrroles; Quinoxalines; S-Nitroso-N-Acetylpenicillamine; Tumor Necrosis Factor-alpha | 1998 |
A new pyrrolyl-quinoxalinedione series of non-NMDA glutamate receptor antagonists: pharmacological characterization and comparison with NBQX and valproate in the kindling model of epilepsy.
Topics: Amygdala; Animals; Anticonvulsants; Binding, Competitive; Cell Death; Electroshock; Epilepsy, Temporal Lobe; Excitatory Amino Acid Antagonists; Female; GABA Agents; Kindling, Neurologic; Kinetics; Male; Mice; Mice, Inbred Strains; Neurons; Phenylurea Compounds; Pyrroles; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Temporal Lobe; Valproic Acid | 1999 |
SPD 502: a water-soluble and in vivo long-lasting AMPA antagonist with neuroprotective activity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Binding, Competitive; Cell Membrane; Cells, Cultured; Cerebral Cortex; Electroshock; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glycine; Isoquinolines; Kainic Acid; Kinetics; Male; Membrane Potentials; Mice; Mice, Inbred Strains; Molecular Structure; Neurons; Neuroprotective Agents; Patch-Clamp Techniques; Pipecolic Acids; Pyrroles; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Seizures; Stereoisomerism; Tetrahydroisoquinolines | 1999 |
Novel vasopressin V2 receptor-selective antagonists, pyrrolo[2,1-a]quinoxaline and pyrrolo[2,1-c][1,4]benzodiazepine derivatives.
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Benzodiazepines; Diuresis; Diuretics; In Vitro Techniques; Pyrroles; Quinoxalines; Rats; Structure-Activity Relationship; Vasopressins | 1999 |
Pyrroloquinoxaline derivatives as high-affinity and selective 5-HT(3) receptor agonists: synthesis, further structure-activity relationships, and biological studies.
Topics: Animals; Anti-Anxiety Agents; Anti-Inflammatory Agents, Non-Steroidal; Blood-Brain Barrier; Brain; Guanidine; Guinea Pigs; Hybrid Cells; In Vitro Techniques; Ligands; Male; Pyrroles; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Serotonin Antagonists; Serotonin Receptor Agonists; Structure-Activity Relationship | 1999 |
alpha(2A)-adrenergic receptor stimulation potentiates calcium release in platelets by modulating cAMP levels.
Topics: Adrenergic alpha-Agonists; Aspirin; Blood Platelets; Brimonidine Tartrate; Calcium; Calcium Chloride; Carbazoles; Cyclic AMP; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Inhibitors; Epinephrine; Humans; Indoles; Inositol 1,4,5-Trisphosphate; Models, Biological; Phosphorylation; Platelet Activating Factor; Platelet Activation; Platelet Glycoprotein GPIIb-IIIa Complex; Prostaglandins E; Pyrroles; Quinoxalines; Receptors, Adrenergic, alpha-2; Stimulation, Chemical; Thapsigargin; Thimerosal; Thrombin; Time Factors | 2000 |
The role of afferents to the locus coeruleus in the handling stress-induced increase in the release of noradrenaline in the medial prefrontal cortex: a dual-probe microdialysis study in the rat brain.
Topics: Animals; Benzylamines; Bicuculline; Idazoxan; Locus Coeruleus; Male; Microdialysis; Norepinephrine; Phosphinic Acids; Piperazines; Prefrontal Cortex; Pyrimidines; Pyrroles; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Receptors, Corticotropin-Releasing Hormone; Receptors, GABA; Receptors, Glutamate; Stress, Physiological | 2000 |
Pharmacological profile of VP-343, a novel selective vasopressin V2 receptor antagonist, in rats.
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Benzazepines; Blood Pressure; Diuretics; Electrolytes; Female; Furosemide; Male; Mice; Mice, Inbred ICR; Pyrroles; Quinoxalines; Rats; Rats, Brattleboro; Rats, Sprague-Dawley; Receptors, Vasopressin; Urodynamics | 2000 |
Prolongation of mouse skin allograft survival by novel agonists selective for retinoic acid receptor-alpha.
Topics: Animals; Benzoates; Furans; Graft Survival; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Pyrroles; Quinoxalines; Receptors, Retinoic Acid; Retinoic Acid Receptor alpha; Skin Transplantation; Transplantation, Homologous | 2000 |
Interplay between nitric oxide and vasoactive intestinal polypeptide in the pig gastric fundus smooth muscle.
Topics: Adenine; Adenylyl Cyclase Inhibitors; Amidines; Animals; Arginine; Benzylamines; Carbazoles; Colforsin; Cyclic AMP; Dexamethasone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gastric Fundus; In Vitro Techniques; Indoles; Isoquinolines; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitroarginine; Oxadiazoles; Protein Kinase Inhibitors; Pyrroles; Quinoxalines; Sulfonamides; Swine; Thionucleotides; Vasoactive Intestinal Peptide | 2000 |
Effects of sustained administration of the serotonin and norepinephrine reuptake inhibitor venlafaxine: II. In vitro studies in the rat.
Topics: Adrenergic alpha-Agonists; Animals; Autoreceptors; Brimonidine Tartrate; Carrier Proteins; Cricetinae; Cyclohexanols; Dose-Response Relationship, Drug; Hippocampus; In Vitro Techniques; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Pyridines; Pyrroles; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1B; Receptors, Adrenergic, alpha-2; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Plasma Membrane Transport Proteins; Serotonin Receptor Agonists; Symporters; Time Factors; Tritium; Venlafaxine Hydrochloride | 2000 |
The therapeutic efficacy of VP-343, a selective vasopressin V2 receptor antagonist, in the experimental SIADH rat model.
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Deamino Arginine Vasopressin; Inappropriate ADH Syndrome; Male; Osmolar Concentration; Pyrroles; Quinoxalines; Rats; Rats, Sprague-Dawley; Renal Agents; Sodium; Urination; Urine | 2000 |
Histopathological study of kidney abnormalities in an experimental SIADH rat model and its application to the evaluation of the pharmacologic profile of VP-343, a selective vasopressin V2 receptor antagonist.
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Deamino Arginine Vasopressin; Diuretics; Histocytochemistry; Inappropriate ADH Syndrome; Kidney; Male; Organ Size; Osmolar Concentration; Pyrroles; Quinoxalines; Rats; Rats, Sprague-Dawley; Renal Agents; Sodium; Urodynamics | 2001 |
Modification of serotonin neuron properties in mice lacking 5-HT1A receptors.
Topics: Animals; Autoreceptors; Brimonidine Tartrate; Hippocampus; In Vitro Techniques; Male; Mice; Neurons; Norepinephrine; Pyridines; Pyrroles; Quinoxalines; Raphe Nuclei; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptors, Adrenergic, alpha-2; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Receptor Agonists; Sumatriptan; Tritium | 2002 |
Okadaic acid inhibits relaxant neural transmission in rat gastric fundus in vitro.
Topics: Animals; Carbazoles; Electric Stimulation; Enzyme Inhibitors; Gastric Fundus; Gastrointestinal Agents; Hydrazines; In Vitro Techniques; Indoles; Male; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Nitric Oxide Donors; Nitroarginine; Nitrogen Oxides; Okadaic Acid; Oxadiazoles; Phosphodiesterase Inhibitors; Phosphoprotein Phosphatases; Purinones; Pyrroles; Quinoxalines; Rats; Rats, Wistar; Synaptic Transmission; Vasoactive Intestinal Peptide | 2002 |
Quinoxaline-oligopyrroles: improved pyrrole-based anion receptors.
Topics: Anions; Binding Sites; Chemical Phenomena; Chemistry; Kinetics; Molecular Structure; Pyrroles; Quinoxalines; Receptors, Cell Surface | 2002 |
Neurotransmitter release and its presynaptic modulation in the rat hippocampus after selective damage to cholinergic or/and serotonergic afferents.
Topics: 5,7-Dihydroxytryptamine; Acetylcholine; Adrenergic alpha-Agonists; Animals; Antibodies, Monoclonal; Biogenic Monoamines; Brimonidine Tartrate; Choline O-Acetyltransferase; Cholinergic Agents; Cholinergic Fibers; Electric Stimulation; Hippocampus; Immunotoxins; Male; N-Glycosyl Hydrolases; Neurons, Afferent; Neurotoxins; Nicotine; Nicotinic Agonists; Norepinephrine; Organ Culture Techniques; Pyridines; Pyrroles; Quinoxalines; Rats; Rats, Long-Evans; Ribosome Inactivating Proteins, Type 1; Saporins; Serotonin; Serotonin Agents; Serotonin Receptor Agonists | 2003 |
Comparative study of isoflavone, quinoxaline and oxindole families of anti-angiogenic agents.
Topics: Angiogenesis Inhibitors; Endothelium, Vascular; Humans; Indoles; Isoflavones; Neoplasms; Neovascularization, Pathologic; Oxindoles; Propionates; Pyrroles; Quinoxalines | 2002 |
Effect of SNI-2011 on amylase secretion from parotid tissue in rats and in neuronal nitric oxide synthase knockout mice.
Topics: Alkaloids; Amylases; Animals; Azepines; Benzoates; Benzylamines; Calcium; Calcium Channel Blockers; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Carbazoles; Chelating Agents; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Estrenes; Gallic Acid; Genotype; Guanylate Cyclase; Imidazoles; In Vitro Techniques; Indoles; Male; Mice; Mice, Knockout; Molsidomine; Muscarinic Agonists; Myosin-Light-Chain Kinase; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxadiazoles; Parotid Gland; Penicillamine; Phosphodiesterase Inhibitors; Pilocarpine; Protein Kinase Inhibitors; Pyrroles; Pyrrolidinones; Quinoxalines; Quinuclidines; Rats; Rats, Wistar; Sulfonamides; Thiophenes; Type C Phospholipases | 2003 |
Presynaptic modulation of acetylcholine, noradrenaline, and serotonin release in the hippocampus of aged rats with various levels of memory impairments.
Topics: Acetylcholine; Acetylcholinesterase; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aging; Analysis of Variance; Animals; Behavior, Animal; Brimonidine Tartrate; Choline O-Acetyltransferase; Female; Hippocampus; Idazoxan; In Vitro Techniques; Maze Learning; Memory Disorders; Methiothepin; Muscarinic Agonists; Norepinephrine; Oxotremorine; Presynaptic Terminals; Pyridines; Pyrroles; Quinoxalines; Rats; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Swimming; Tritium | 2003 |
Presynaptic regulation of neurotransmitter release in the cortex of aged rats with differential memory impairments.
Topics: Acetylcholine; Acetylcholinesterase; Adrenergic alpha-Agonists; Aging; Animals; Brimonidine Tartrate; Cerebral Cortex; Choline; Choline O-Acetyltransferase; Chromatography, High Pressure Liquid; Electric Stimulation; Female; Maze Learning; Memory Disorders; Muscarinic Agonists; Neurotransmitter Agents; Norepinephrine; Oxotremorine; Pyridines; Pyrroles; Quinoxalines; Rats; Rats, Long-Evans; Receptors, Presynaptic; Serotonin; Serotonin Receptor Agonists | 2003 |
Quinoxaline chemistry. Part 16. 4-substituted anilino and 4-substituted phenoxymethyl pyrrolo[1,2-a]quinoxalines and N-[4-(pyrrolo[1,2-a]quinoxalin-4-yl)amino and hydroxymethyl]benzoyl glutamates. Synthesis and evaluation of in vitro biological activity.
Topics: Aniline Compounds; Animals; Anti-Bacterial Agents; Anti-HIV Agents; Antineoplastic Agents; Cattle; Cell Line; Drug Screening Assays, Antitumor; Folic Acid Antagonists; Glutamates; HIV-1; Humans; Mice; Pyrroles; Quinoxalines; Structure-Activity Relationship; Tumor Cells, Cultured | 2003 |
Pyrazine analogues of dipyrrolylquinoxalines.
Topics: Crystallography, X-Ray; Heterocyclic Compounds, 3-Ring; Heterocyclic Compounds, 4 or More Rings; Molecular Conformation; Molecular Structure; Pyrazines; Pyrroles; Quinoxalines | 2003 |
AMPA-receptor activation is involved in the antiamnesic effect of DM 232 (unifiram) and DM 235 (sunifiram).
Topics: Amnesia; Animals; Avoidance Learning; Cognition; Dose-Response Relationship, Drug; Electrophysiology; Hippocampus; Kynurenic Acid; Male; Mice; N-Methylaspartate; Nootropic Agents; Piperazines; Pyrroles; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA | 2003 |
Role of adenylate and guanylate cyclases in beta1-, beta2-, and beta3-adrenoceptor-mediated relaxation of internal anal sphincter smooth muscle.
Topics: Adenine; Adenylyl Cyclases; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Blotting, Western; Carbazoles; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; GTP-Binding Proteins; Guanylate Cyclase; Indoles; Male; Muscle Relaxation; Muscle, Smooth; Oxadiazoles; Procaterol; Pyrroles; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Receptors, Adrenergic, beta-1; Receptors, Adrenergic, beta-2; Receptors, Adrenergic, beta-3; Suramin; Xamoterol | 2004 |
Synthesis, antimalarial activity, and molecular modeling of new pyrrolo[1,2-a]quinoxalines, bispyrrolo[1,2-a]quinoxalines, bispyrido[3,2-e]pyrrolo[1,2-a]pyrazines, and bispyrrolo[1,2-a]thieno[3,2-e]pyrazines.
Topics: Animals; Antimalarials; Cell Line; Crystallography, X-Ray; Drug Resistance; Erythrocytes; Hemeproteins; Humans; In Vitro Techniques; Models, Molecular; Plasmodium falciparum; Protein Binding; Pyrazines; Pyridines; Pyrroles; Quinoxalines; Rats; Structure-Activity Relationship | 2004 |
5-Hydroxytryptamine 1B receptors mediate presynaptic inhibition of monosynaptic IPSC in the rat dorsolateral septal nucleus.
Topics: Analysis of Variance; Animals; Benzamides; Biphenyl Compounds; Calcium Channel Blockers; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Membrane Potentials; Muscimol; Neural Inhibition; Neurons; omega-Agatoxin IVA; omega-Conotoxin GVIA; Oxadiazoles; Patch-Clamp Techniques; Pertussis Toxin; Phosphinic Acids; Piperazines; Presynaptic Terminals; Propanolamines; Pyridines; Pyrroles; Quinoxalines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1B; Septal Nuclei; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Synaptic Transmission | 2004 |
Behavioural effects of the novel AMPA/GluR5 selective receptor antagonist NS1209 after systemic administration in animal models of experimental pain.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Excitatory Amino Acid Antagonists; Male; Morphine; Narcotics; Pain; Pain Measurement; Pain Threshold; Peripheral Nervous System Diseases; Pyrroles; Quinoxalines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Kainic Acid; Tetrahydroisoquinolines; Time Factors | 2004 |
Presenilin attenuates receptor-mediated signaling and synaptic function.
Topics: Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Carbamates; Carbazoles; Cell Adhesion Molecules; Cell Line, Tumor; Cell Membrane; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; DCC Receptor; Dipeptides; Endopeptidases; Excitatory Postsynaptic Potentials; Genes, DCC; Glutamic Acid; Indoles; Lidocaine; Membrane Proteins; Memory; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurites; Neuroblastoma; Neurons; Piperazines; Presenilin-1; Protein Processing, Post-Translational; Pyrroles; Quinoxalines; Rats; Receptors, Cell Surface; Recombinant Fusion Proteins; Second Messenger Systems; Synaptic Transmission; Transfection; Tumor Suppressor Proteins | 2005 |
5-HT1B receptor-mediated presynaptic inhibition of GABA release in the suprachiasmatic nucleus.
Topics: Animals; Bicuculline; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Membrane Potentials; Mice; Mice, Knockout; Neural Inhibition; Neurons; Patch-Clamp Techniques; Presynaptic Terminals; Pyridines; Pyrroles; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1B; Serotonin Receptor Agonists; Suprachiasmatic Nucleus; Tetrodotoxin; Time Factors; Valine | 2005 |
Design and optimization of tricyclic phtalimide analogues as novel inhibitors of HIV-1 integrase.
Topics: Anti-HIV Agents; Binding Sites; Cell Line; Heterocyclic Compounds, 3-Ring; HIV Integrase; HIV Integrase Inhibitors; HIV-1; Humans; Models, Molecular; Phthalimides; Protein Binding; Pyrroles; Quinoxalines; Structure-Activity Relationship | 2005 |
Photophysical studies of anion-induced colorimetric response and amplified fluorescence quenching in dipyrrolylquinoxaline-containing conjugated polymers.
Topics: Anions; Colorimetry; Coloring Agents; Fluorescence; Hydrogen Bonding; Molecular Structure; Photochemistry; Polymers; Pyrroles; Quinoxalines | 2006 |
Chronic CO levels have [corrected] a beneficial effect on vascular relaxation in diabetes.
Topics: Acetylcholine; Animals; Aorta; Biliverdine; Blotting, Western; Carbon Monoxide; Chromium; Densitometry; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Endothelium, Vascular; Femoral Artery; Guanylate Cyclase; Heme; Immunohistochemistry; Male; Mesoporphyrins; Muscle Contraction; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Organometallic Compounds; Oxadiazoles; Oxidative Stress; Protoporphyrins; Pyrazines; Pyrroles; Quinoxalines; Rats; Rats, Sprague-Dawley; Stress, Mechanical; Time Factors | 2006 |
Does the donor-acceptor concept work for designing synthetic metals? III. Theoretical investigation of copolymers between quinoid acceptors and aromatic donors.
Topics: Metals; Models, Chemical; Models, Molecular; Molecular Conformation; Polymers; Pyrazines; Pyrroles; Quinoxalines; Thiadiazoles; Thiophenes | 2006 |
The structure of a mixed GluR2 ligand-binding core dimer in complex with (S)-glutamate and the antagonist (S)-NS1209.
Topics: Animals; Binding Sites; Crystallography, X-Ray; Dimerization; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Hydrogen Bonding; Macromolecular Substances; Models, Molecular; Molecular Structure; Protein Structure, Quaternary; Pyrroles; Quinoxalines; Rats; Receptors, AMPA; Recombinant Proteins; Tetrahydroisoquinolines; Thermodynamics | 2006 |
Presynaptic modulation of 5-HT release in the rat septal region.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic alpha-Agonists; Analgesics, Non-Narcotic; Animals; Brimonidine Tartrate; Calcium; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; In Vitro Techniques; Male; Neurons; Presynaptic Terminals; Pyridines; Pyrroles; Quinoxalines; Quipazine; Rats; Rats, Wistar; Septum of Brain; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists | 2007 |
Synthesis and biological evaluation of imidazoquinoxalinones, imidazole analogues of pyrroloiminoquinone marine natural products.
Topics: Animals; Antineoplastic Agents; Biological Products; Cell Line, Tumor; DNA Topoisomerases, Type II; Drug Screening Assays, Antitumor; Humans; Imidazoles; Marine Biology; Mice; Pyrroles; Quinolones; Quinoxalines; Structure-Activity Relationship; Toxicity Tests, Acute | 2007 |
G-protein inwardly rectifying potassium channels are involved in the hypotensive effect of I1-imidazoline receptor selective ligands.
Topics: Animals; Blood Pressure; Cisterna Magna; Cyclopropanes; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Imidazoles; Imidazoline Receptors; Injections, Spinal; Male; Pyrroles; Quinoxalines; Rabbits | 2008 |
A one-pot coupling/hydrolysis/condensation process to pyrrolo[1,2-a]quinoxaline.
Topics: Hydrolysis; Molecular Structure; Pyrroles; Quinoxalines | 2008 |
Pharmacophore mapping of a series of pyrrolopyrimidines, indolopyrimidines and their congeners as multidrug-resistance-associated protein (MRP1) modulators.
Topics: Computer Simulation; Humans; Hydrogen Bonding; Indoles; Inhibitory Concentration 50; Isoxazoles; Models, Molecular; Multidrug Resistance-Associated Proteins; Pyrimidines; Pyrroles; Quantitative Structure-Activity Relationship; Quinolones; Quinoxalines; Silymarin; Sulfonamides; Thiophenes | 2008 |
New ferrocenic pyrrolo[1,2-a]quinoxaline derivatives: synthesis, and in vitro antimalarial activity.
Topics: Amines; Animals; Antimalarials; Cell Line; Cell Survival; Ferrous Compounds; Humans; Hydrophobic and Hydrophilic Interactions; Metallocenes; Molecular Structure; Plasmodium falciparum; Pyrroles; Quinoxalines; Structure-Activity Relationship | 2008 |
Synthesis of new pyrrolo[1,2-a]quinoxaline derivatives as potential inhibitors of Akt kinase.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Drug Discovery; Humans; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrroles; Quinoxalines; Structure-Activity Relationship | 2008 |
Specific targeting of peripheral serotonin 5-HT(3) receptors. Synthesis, biological investigation, and structure-activity relationships.
Topics: Animals; Baroreflex; Chemical Phenomena; Female; Guinea Pigs; Heart; Heart Atria; Male; Mice; Models, Molecular; Myocardium; Pyrroles; Quinoxalines; Quipazine; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Serotonin 5-HT3 Receptor Agonists; Structure-Activity Relationship | 2009 |
Novel, potent, and selective quinoxaline-based 5-HT(3) receptor ligands. 1. Further structure-activity relationships and pharmacological characterization.
Topics: Animals; Blood-Brain Barrier; Drug Partial Agonism; Guinea Pigs; Heart Rate; In Vitro Techniques; Ligands; Myocardial Contraction; Pyrroles; Quinoxalines; Rats; Reflex; Serotonin 5-HT3 Receptor Agonists; Serotonin 5-HT3 Receptor Antagonists; Structure-Activity Relationship | 2009 |
Electrochemistry and spectroelectrochemistry of beta,beta'-fused quinoxalinoporphyrins and related extended bis-porphyrins with Co(III), Co(II), and Co(I) central metal ions.
Topics: Cobalt; Electrochemistry; Ions; Metalloporphyrins; Molecular Structure; Organometallic Compounds; Pyrroles; Quinoxalines; Spectrophotometry, Ultraviolet | 2010 |
Synthesis and evaluation of the antiproliferative activity of novel pyrrolo[1,2-a]quinoxaline derivatives, potential inhibitors of Akt kinase. Part II.
Topics: Benzimidazoles; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Drug Design; Esters; Female; Humans; Leukemia; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrroles; Quinoxalines | 2010 |
Pt(IV)-catalyzed hydroamination triggered cyclization: a strategy to fused pyrrolo[1,2-a]quinoxalines, indolo[1,2-a]quinoxalines, and indolo[3,2-c]quinolines.
Topics: Amination; Catalysis; Cyclization; Heterocyclic Compounds; Indoles; Molecular Structure; Platinum; Pyrroles; Quinolines; Quinoxalines; Stereoisomerism | 2010 |
Stress-induced priming of glutamate synapses unmasks associative short-term plasticity.
Topics: Animals; Biophysical Phenomena; Biophysics; Chelating Agents; Corticotropin-Releasing Hormone; Dizocilpine Maleate; Drug Interactions; Egtazic Acid; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Exocytosis; Freezing Reaction, Cataleptic; Glutamic Acid; In Vitro Techniques; Male; Neuronal Plasticity; Neurons; Paraventricular Hypothalamic Nucleus; Patch-Clamp Techniques; Pyrimidines; Pyrroles; Quinoxalines; Rats; Rats, Sprague-Dawley; SNARE Proteins; Stress, Physiological; Synapses; Time Factors | 2010 |
Atorvastatin prevents vascular hyporeactivity to norepinephrine in sepsis: role of nitric oxide and α₁-adrenoceptor mRNA expression.
Topics: Animals; Atorvastatin; Enzyme Inhibitors; Guanylate Cyclase; Heptanoic Acids; Mice; Nitric Oxide; Norepinephrine; Oxadiazoles; Polymerase Chain Reaction; Pyrroles; Quinoxalines; Receptors, Adrenergic, alpha-1; RNA, Messenger; Sepsis; Vasoconstrictor Agents | 2011 |
New ferrocenic pyrrolo[1,2-a]quinoxaline derivatives: synthesis, and in vitro antimalarial activity--Part II.
Topics: Antimalarials; Cell Line; Cell Proliferation; Crystallography, X-Ray; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Ferrous Compounds; Humans; Metallocenes; Models, Molecular; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium falciparum; Pyrroles; Quinoxalines; Stereoisomerism; Structure-Activity Relationship | 2011 |
Synthesis of Pyrrolo[1,2-a]quinoxalines via gold(I)-mediated cascade reactions.
Topics: Gold; Pyrroles; Quinoxalines; Temperature | 2011 |
Disproportionation of dipyrrolylquinoxaline radical anions via the internal protons of the pyrrole moieties.
Topics: Anions; Free Radicals; Molecular Structure; Protons; Pyrroles; Quinoxalines | 2011 |
α(2) Adrenergic and imidazoline receptor agonists prevent cue-induced cocaine seeking.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic beta-Antagonists; Animals; Brimonidine Tartrate; Clonidine; Cocaine; Cues; Dose-Response Relationship, Drug; Drug Interactions; Drug-Seeking Behavior; Extinction, Psychological; Guanfacine; Imidazoles; Imidazoline Receptors; Isoquinolines; Male; Motor Activity; Naphthyridines; Prazosin; Propranolol; Pyrimidines; Pyrroles; Quinoxalines; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Self Administration | 2011 |
Semaphorin-PlexinD1 signaling limits angiogenic potential via the VEGF decoy receptor sFlt1.
Topics: Angiogenesis Inhibitors; Animals; Animals, Genetically Modified; Aorta; Cell Movement; Cell Transplantation; Embryo, Nonmammalian; Endothelial Cells; Endothelium; Gene Expression Regulation, Developmental; In Vitro Techniques; Indoles; Luminescent Proteins; Molecular Sequence Data; Neovascularization, Physiologic; Oligodeoxyribonucleotides, Antisense; Pyrroles; Quinoxalines; Receptors, Cell Surface; Receptors, Notch; RNA, Messenger; Semaphorins; Signal Transduction; Thiazolidinediones; Vascular Endothelial Growth Factor Receptor-1; Zebrafish; Zebrafish Proteins | 2011 |
One-pot synthesis of pyrrolo[1,2-a]quinoxalines.
Topics: Crystallography, X-Ray; Models, Molecular; Molecular Structure; Pyrroles; Quinoxalines; Stereoisomerism | 2011 |
One-pot synthesis of pyrrolo[1,2-a]quinoxaline derivatives via iron-promoted aryl nitro reduction and aerobic oxidation of alcohols.
Topics: Alcohols; Catalysis; Combinatorial Chemistry Techniques; Cyclization; Iron; Molecular Structure; Oxidation-Reduction; Pyrroles; Quinoxalines | 2012 |
Pyrrolo[2,3-b]quinoxalines as inhibitors of firefly luciferase: their Cu-mediated synthesis and evaluation as false positives in a reporter gene assay.
Topics: Animals; Enzyme Inhibitors; Fireflies; Genes, Reporter; Luciferases, Firefly; Models, Molecular; Pyrroles; Quinoxalines | 2012 |
Pyrrolo[1,2-a]quinoxalines: novel synthesis via annulation of 2-alkylquinoxalines.
Topics: Alkylation; Glycerol; Models, Molecular; Molecular Structure; Pyrroles; Quinoxalines | 2012 |
A chain of π-stacked molecules in 4-(2-chlorophenyl)pyrrolo[1,2-a]quinoxaline and a hydrogen-bonded sheet in (4RS)-4-(1,3-1,3-benzodioxol-6-yl)-4,5-dihydropyrrolo[1,2-a]quinoxaline.
Topics: Crystallography, X-Ray; Electrons; Hydrogen Bonding; Molecular Conformation; Molecular Structure; Pyrroles; Quinoxalines; Stereoisomerism | 2013 |
Synthesis and biological evaluation of novel substituted pyrrolo[1,2-a]quinoxaline derivatives as inhibitors of the human protein kinase CK2.
Topics: Casein Kinase II; Dose-Response Relationship, Drug; Humans; Models, Molecular; Molecular Structure; Protein Kinase Inhibitors; Pyrroles; Quinoxalines; Structure-Activity Relationship | 2013 |
Sensitive and selective electrochemical determination of quinoxaline-2-carboxylic acid based on bilayer of novel poly(pyrrole) functional composite using one-step electro-polymerization and molecularly imprinted poly(o-phenylenediamine).
Topics: Animals; Chickens; Electrochemical Techniques; Electrodes; Graphite; Indoles; Isoindoles; Meat; Molecular Imprinting; Phenylenediamines; Polymerization; Polymers; Pyrroles; Quinoxalines; Swine | 2014 |
Novel approach for the synthesis of pyrrolo[2,1-c][1,4]benzoxazines and pyrrolo[1,2-a]quinoxalines.
Topics: Aminophenols; Benzenesulfonates; Benzoxazines; Carboxylic Acids; Phenylenediamines; Pyrroles; Quinoxalines | 2014 |
4,5-Dihydropyrrolo[1,2-a]quinoxalines: a tunable and regenerable biomimetic hydrogen source.
Topics: Amines; Benzoxazines; Biomimetics; Catalysis; Hydrogen; Hydrogenation; Molecular Structure; Pyrroles; Quinoxalines | 2014 |
72nd annual meeting of the American Academy of Dermatology.
Topics: Antifungal Agents; Attention Deficit Disorder with Hyperactivity; Boron Compounds; Botulinum Toxins, Type A; Bridged Bicyclo Compounds, Heterocyclic; Brimonidine Tartrate; Depression; Dermatitis, Atopic; Food Hypersensitivity; Humans; Immunologic Factors; Ivermectin; Phosphodiesterase Inhibitors; Phototherapy; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Quinoxalines; Skin Diseases; Societies, Medical; Thalidomide; Triazoles; United States | 2014 |
Pyrrolo[3,2-b]quinoxaline derivatives as types I1/2 and II Eph tyrosine kinase inhibitors: structure-based design, synthesis, and in vivo validation.
Topics: Animals; Antineoplastic Agents; Binding, Competitive; Cell Line, Tumor; Computer Simulation; Crystallography, X-Ray; Drug Design; Drug Screening Assays, Antitumor; Heterografts; Humans; Male; Mice, Inbred ICR; Mice, Nude; Molecular Docking Simulation; Neoplasm Transplantation; Pyrroles; Quinoxalines; Receptor, EphA3; Receptor, EphB4; Structure-Activity Relationship; Thermodynamics | 2014 |
Permeability analysis of neuroactive drugs through a dynamic microfluidic in vitro blood-brain barrier model.
Topics: Amines; Animals; Benzazepines; Biological Transport; Blood-Brain Barrier; Cell Survival; Cells, Cultured; Coculture Techniques; Cyclohexanecarboxylic Acids; Endothelial Cells; Ethosuximide; Gabapentin; gamma-Aminobutyric Acid; Indoles; L-Lactate Dehydrogenase; Mice; Microfluidic Analytical Techniques; Neuroglia; Permeability; Piperidines; Pyrroles; Quinoxalines; Rats; Rats, Sprague-Dawley; Sertraline; Sunitinib; Tetrahydronaphthalenes; Valine; Varenicline | 2014 |
Ligand-free Pd-catalyzed C-N cross-coupling/cyclization strategy: an unprecedented access to 1-thienyl pyrroloquinoxalines for the new approach towards apoptosis.
Topics: Animals; Apoptosis; Catalysis; Cyclization; Dose-Response Relationship, Drug; Molecular Structure; Palladium; Phosphodiesterase 4 Inhibitors; Pyrroles; Quinoxalines; Structure-Activity Relationship; Thiophenes; Zebrafish | 2014 |
Interaction of ERK1/2 and Smad2/3 signaling pathways in TGF-β1-induced TIMP-3 expression in rat chondrocytes.
Topics: Animals; Cells, Cultured; Chondrocytes; Enzyme Activation; Flavonoids; Imidazoles; Isoquinolines; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 3; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Pyrroles; Quinoxalines; Rats; Smad2 Protein; Smad3 Protein; Tissue Inhibitor of Metalloproteinase-3; Transforming Growth Factor beta1; Up-Regulation | 2014 |
Fragmentation of the quinoxaline N-oxide bond to the ˙OH radical upon one-electron bioreduction.
Topics: Antineoplastic Agents; Humans; Hydroxyl Radical; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Oxides; Pyrroles; Quinoxalines; Tirapazamine; Triazines | 2014 |
Synthesis of highly functionalized polycyclic quinoxaline derivatives using visible-light photoredox catalysis.
Topics: Catalysis; Cyanides; Cyclization; Light; Oxidation-Reduction; Polycyclic Compounds; Pyrroles; Quinoxalines | 2014 |
H8-BINOL chiral imidodiphosphoric acids catalyzed enantioselective synthesis of dihydroindolo-/-pyrrolo[1,2-a]quinoxalines.
Topics: Anti-HIV Agents; Catalysis; Diphosphonates; HIV-1; Ketones; Molecular Structure; Naphthols; Pyrroles; Quinoxalines; Stereoisomerism | 2014 |
Microwave Controlled Reductive Cyclization: A Selective Synthesis of Novel Benzimidazole-alkyloxypyrrolo[1,2-a]quinoxalinones.
Topics: Benzimidazoles; Crystallography, X-Ray; Cyclization; Microwaves; Models, Molecular; Molecular Structure; Pyrroles; Quinoxalines | 2015 |
One-Pot Synthesis of Pyrrolo[1,2-a]quinoxaline Derivatives via a Copper-Catalyzed Aerobic Oxidative Domino Reaction.
Topics: Catalysis; Copper; Molecular Structure; Organometallic Compounds; Oxidation-Reduction; Pyrroles; Quinoxalines | 2015 |
Iron-Catalyzed Intramolecular C(sp(2))-N Cyclization of 1-(N-Arylpyrrol-2-yl)ethanone O-Acetyl Oximes toward Pyrrolo[1,2-a]quinoxaline Derivatives.
Topics: Catalysis; Cyclization; Iron; Molecular Structure; Oximes; Pyrroles; Quinoxalines | 2015 |
Dipyrrolylquinoxaline difluoroborates with intense red solid-state fluorescence.
Topics: Borates; Fluorescent Dyes; Models, Molecular; Molecular Conformation; Pyrroles; Quinoxalines; Spectrometry, Fluorescence | 2015 |
Transforming growth factor-β1 induces type II collagen and aggrecan expression via activation of extracellular signal-regulated kinase 1/2 and Smad2/3 signaling pathways.
Topics: Aggrecans; Animals; Cartilage, Articular; Chondrocytes; Collagen Type II; Enzyme Activation; Female; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Isoquinolines; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Primary Cell Culture; Protein Serine-Threonine Kinases; Pyridines; Pyrroles; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Recombinant Proteins; Signal Transduction; Smad2 Protein; Smad3 Protein; Transforming Growth Factor beta1 | 2015 |
Synthesis and inhibitory effects of novel pyrimido-pyrrolo-quinoxalinedione analogues targeting nucleoproteins of influenza A virus H1N1.
Topics: Antiviral Agents; Dose-Response Relationship, Drug; Influenza A Virus, H1N1 Subtype; Microbial Sensitivity Tests; Molecular Structure; Nucleoproteins; Pyrimidines; Pyrroles; Quinoxalines; Structure-Activity Relationship; Viral Proteins | 2015 |
A Molecular Imaging Approach to Mercury Sensing Based on Hyperpolarized (129)Xe Molecular Clamp Probe.
Topics: Magnetic Resonance Imaging; Mercury; Molecular Imaging; Molecular Probes; Pyrroles; Quinoxalines; Xenon; Xenon Isotopes | 2016 |
Synthesis of Kappa Opioid Antagonists Based On Pyrrolo[1,2-α]quinoxalinones Using an N-Arylation/Condensation/Oxidation Reaction Sequence.
Topics: Carbon-13 Magnetic Resonance Spectroscopy; Oxidation-Reduction; Proton Magnetic Resonance Spectroscopy; Pyrroles; Quinoxalines; Receptors, Opioid, kappa; Spectrometry, Mass, Electrospray Ionization | 2016 |
Structural Basis of Sirtuin 6 Activation by Synthetic Small Molecules.
Topics: Humans; Models, Molecular; Molecular Structure; Pyrroles; Quinoxalines; Sirtuins; Small Molecule Libraries | 2017 |
Synthesis and Antimalarial Activity of New Enantiopure Aminoalcoholpyrrolo[ 1,2-a]quinoxalines.
Topics: Amino Alcohols; Animals; Antimalarials; Cell Line, Tumor; Chloroquine; CHO Cells; Cricetulus; Humans; Mefloquine; Plasmodium falciparum; Pyrroles; Quinoxalines; Stereoisomerism | 2018 |
Application of α-amino acids for the transition-metal-free synthesis of pyrrolo[1,2-a]quinoxalines.
Topics: Amino Acids; Chemistry Techniques, Synthetic; Pyrroles; Quinoxalines | 2017 |
CAY10591, a SIRT1 activator, suppresses cell growth, invasion, and migration in gingival epithelial carcinoma cells.
Topics: Cell Division; Cell Line, Tumor; Cyclopentanes; Dimethyl Sulfoxide; Gingival Neoplasms; Humans; Neoplasm Invasiveness; Neoplasm Metastasis; Pyrroles; Quinoxalines; Reverse Transcriptase Polymerase Chain Reaction; Sirtuin 1 | 2017 |
Novel ATP-competitive Akt inhibitor afuresertib suppresses the proliferation of malignant pleural mesothelioma cells.
Topics: Antineoplastic Agents; Apoptosis; Benzylamines; Caspase 3; Caspase 7; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; Forkhead Box Protein O1; G1 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Glycogen Synthase Kinase 3 beta; Heterocyclic Compounds, 3-Ring; Heterocyclic Compounds, 4 or More Rings; Humans; Imidazoles; Inhibitory Concentration 50; Mesothelioma; Oxadiazoles; Phosphorylation; Phosphorylcholine; Pleural Neoplasms; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrazoles; Pyridines; Pyrimidines; Pyrroles; Quinoxalines; Sulfonamides; Thiadiazoles; Thiophenes | 2017 |
Effects of Nitric Oxide on Voltage-Gated K⁺ Currents in Human Cardiac Fibroblasts through the Protein Kinase G and Protein Kinase A Pathways but Not through S-Nitrosylation.
Topics: Action Potentials; Adenine; Carbazoles; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Humans; Myofibroblasts; Nitric Oxide; Oxadiazoles; Potassium Channels, Voltage-Gated; Pyrroles; Quinoxalines; S-Nitroso-N-Acetylpenicillamine | 2018 |
Discovery of novel anti-tuberculosis agents with pyrrolo[1,2-a]quinoxaline-based scaffold.
Topics: Antineoplastic Agents; Antitubercular Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Pyrroles; Quinoxalines; Structure-Activity Relationship | 2018 |
Kaempferol-induces vasorelaxation via endothelium-independent pathways in rat isolated pulmonary artery.
Topics: Animals; Apamin; Barium Compounds; Calcium Chloride; Chlorides; Dose-Response Relationship, Drug; Endothelium, Vascular; Estradiol; Fulvestrant; Glyburide; In Vitro Techniques; Indomethacin; Isoquinolines; Kaempferols; Male; Morpholines; NG-Nitroarginine Methyl Ester; Oxadiazoles; Peptides; Potassium; Pulmonary Artery; Pyrroles; Quinoxalines; Rats; Sulfonamides; Tetraethylammonium; Vasodilation; Vasodilator Agents | 2018 |
Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells.
Topics: Acetylation; AMP-Activated Protein Kinases; Apoptosis; Autophagosomes; Autophagy; Autophagy-Related Protein-1 Homolog; Cell Cycle; Cell Proliferation; Enzyme Activation; HCT116 Cells; HeLa Cells; Histones; Humans; Intracellular Signaling Peptides and Proteins; Neoplasms; Pyrroles; Quinoxalines; Reactive Oxygen Species; Signal Transduction; Sirtuins | 2018 |
Optimization of Drug Candidates That Inhibit the D-Loop Activity of RAD51.
Topics: Cell Survival; Cycloaddition Reaction; DNA; DNA Repair; DNA Replication; Enzyme Inhibitors; HEK293 Cells; Humans; Molecular Structure; Oxidation-Reduction; Protein Binding; Pyrroles; Quinoxalines; Rad51 Recombinase; Structure-Activity Relationship | 2019 |
Inhibitors of AKT kinase increase LDL receptor mRNA expression by two different mechanisms.
Topics: Aminopyridines; Animals; Benzimidazoles; CHO Cells; Cricetinae; Cricetulus; Hep G2 Cells; Heterocyclic Compounds, 3-Ring; Humans; Imidazoles; Phosphorylcholine; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrazoles; Pyrimidines; Pyrroles; Quinoxalines; Receptors, LDL; Ribonucleosides; RNA Stability; RNA, Messenger; Transcriptional Activation | 2019 |
Differentiation-inducing factor-1 prevents hepatic stellate cell activation through inhibiting GSK3β inactivation.
Topics: Active Transport, Cell Nucleus; Adenine; Animals; Antineoplastic Agents; beta Catenin; Cell Differentiation; Cell Transdifferentiation; Dictyostelium; Dose-Response Relationship, Drug; Glycogen Synthase Kinase 3 beta; Hepatic Stellate Cells; Hexanones; Liver Cirrhosis; Mice; Oxadiazoles; Phosphorylation; Pyrimidines; Pyrroles; Quinoxalines; Signal Transduction | 2019 |
Molecularly imprinted electrochemical sensor based on polypyrrole/dopamine@graphene incorporated with surface molecularly imprinted polymers thin film for recognition of olaquindox.
Topics: Dopamine; Electrochemical Techniques; Electrodes; Graphite; Limit of Detection; Molecular Imprinting; Polymers; Pyrroles; Quinoxalines; Reproducibility of Results; Surface Properties | 2020 |
One-pot sequential coupling reactions as a new practical protocol for the synthesis of unsymmetrical 2,3-diethynyl quinoxalines and 4-ethynyl-substituted pyrrolo[1,2-a]quinoxalines.
Topics: Anti-Bacterial Agents; Catalysis; Micrococcus luteus; Palladium; Pseudomonas aeruginosa; Pyrroles; Quinoxalines | 2021 |
Synthesis of novel 4,5-dihydropyrrolo[1,2-a]quinoxalines, pyrrolo[1,2-a]quinoxalin]-2-ones and their antituberculosis and anticancer activity.
Topics: A549 Cells; Antineoplastic Agents; Antitubercular Agents; Cell Survival; Dose-Response Relationship, Drug; Drug Design; HeLa Cells; Hep G2 Cells; Humans; Inhibitory Concentration 50; MCF-7 Cells; Melanoma, Experimental; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Neoplasms; Pyrroles; Quinoxalines; Structure-Activity Relationship | 2020 |
Pyrrolo[1,2-a]quinoxalines: Insulin Mimetics that Exhibit Potent and Selective Inhibition against Protein Tyrosine Phosphatase 1B.
Topics: Animals; Cell Differentiation; Cell Line; Cell Survival; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glucose; Hep G2 Cells; Humans; Insulin; Mice; Models, Molecular; Molecular Structure; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Pyrroles; Quinoxalines; Structure-Activity Relationship | 2020 |
Inhibition of Kpnβ1 mediated nuclear import enhances cisplatin chemosensitivity in cervical cancer.
Topics: Active Transport, Cell Nucleus; Antineoplastic Agents; Apoptosis; beta Karyopherins; Biomarkers, Tumor; Cell Movement; Cell Proliferation; Cisplatin; Drug Synergism; Drug Therapy, Combination; Female; Gene Expression Regulation, Neoplastic; Humans; Pyrroles; Quinoxalines; Tumor Cells, Cultured; Uterine Cervical Neoplasms | 2021 |
Design, Synthesis and Anticancer Activity of New Polycyclic: Imidazole, Thiazine, Oxathiine, Pyrrolo-Quinoxaline and Thienotriazolopyrimidine Derivatives.
Topics: Antineoplastic Agents; Cell Line, Tumor; Drug Design; Drug Evaluation, Preclinical; Humans; Imidazoles; Pyrimidines; Pyrroles; Quinoxalines; Structure-Activity Relationship; Thiazines | 2021 |
FGFR alterations in urothelial carcinoma: Picking the right target.
Topics: Carcinoma, Transitional Cell; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Gene Fusion; Humans; Molecular Targeted Therapy; Morpholines; Mutation; Phenylurea Compounds; Piperazines; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; Pyrroles; Quinoxalines; Receptor, Fibroblast Growth Factor, Type 2; Receptor, Fibroblast Growth Factor, Type 3; Thiophenes; Urinary Bladder Neoplasms | 2021 |
A Computer-Driven Scaffold-Hopping Approach Generating New PTP1B Inhibitors from the Pyrrolo[1,2-a]quinoxaline Core.
Topics: Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Models, Molecular; Molecular Structure; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Pyrroles; Quinoxalines; Structure-Activity Relationship | 2021 |
Pyrrolo[1,2-a]quinoxal-5-inium salts and 4,5-dihydropyrrolo[1,2-a]quinoxalines: Synthesis, activity and computational docking for protein tyrosine phosphatase 1B.
Topics: Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Molecular Docking Simulation; Molecular Structure; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Pyrroles; Quinoxalines; Salts; Structure-Activity Relationship | 2021 |
Pyridazino-pyrrolo-quinoxalinium salts as highly potent and selective leishmanicidal agents targeting trypanothione reductase.
Topics: Antiprotozoal Agents; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Leishmania infantum; Molecular Structure; NADH, NADPH Oxidoreductases; Parasitic Sensitivity Tests; Pyridazines; Pyrroles; Quinoxalines; Salts; Structure-Activity Relationship; THP-1 Cells | 2022 |
The local wound environment is a key determinant of the outcome of TGFβ signaling on the fibrotic response of CD44
Topics: Actins; Animals; Blotting, Western; Capsule Opacification; Cataract Extraction; Cell Proliferation; Chick Embryo; Collagen Type I; Disease Models, Animal; Fibronectins; Fibrosis; Hyaluronan Receptors; Imidazoles; Integrin alphaVbeta3; Microscopy, Fluorescence; Myofibroblasts; Posterior Capsule of the Lens; Postoperative Complications; Pyrazoles; Pyrroles; Quinoxalines; Receptor, Transforming Growth Factor-beta Type I; Signal Transduction; Transforming Growth Factor beta; Wound Healing | 2021 |
An Isoxazole Strategy for Molybdenum-Mediated Synthesis of 5-Mono- and 4,5-Disubstituted 1
Topics: Isoxazoles; Molybdenum; Pyrroles; Quinoxalines | 2022 |
Application of
Topics: Carbon; Deanol; Pyrroles; Quinoxalines | 2022 |
Quinoxalinone substituted pyrrolizine (4h)-induced dual inhibition of AKT and ERK instigates apoptosis in breast and colorectal cancer by modulating mitochondrial membrane potential.
Topics: Animals; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Extracellular Signal-Regulated MAP Kinases; Humans; Membrane Potential, Mitochondrial; Mice; Mitogen-Activated Protein Kinase 3; Molecular Docking Simulation; Proto-Oncogene Proteins c-akt; Pyrroles; Quinoxalines | 2023 |