Compounds > pyrroles
Page last updated: 2024-08-18

pyrroles and pyrrolopyrimidine

pyrroles has been researched along with pyrrolopyrimidine in 88 studies

Research

Studies (88)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's6 (6.82)29.6817
2010's65 (73.86)24.3611
2020's17 (19.32)2.80

Authors

AuthorsStudies
Betschart, C; Cowan-Jacob, SW; Ehara, T; Gohda, K; Gunji, H; Hitomi, Y; Horiuchi, M; Irie, O; Iwasaki, A; Iwasaki, G; Kometani, M; Lattmann, R; Masuya, K; Matsuura, N; Missbach, M; Miyake, T; Nonomura, K; Ohmori, O; Sakaki, J; Tada, S; Teno, N; Umemura, I1
Ehara, T; Fukaya, H; Hitomi, Y; Irie, O; Iwasaki, G; Kometani, M; Kosaka, T; Masuya, K; Matsuura, N; Miyake, T; Nonomura, K; Sugiyama, I; Teno, N; Toriyama, K; Uchiyama, N; Umemura, I1
Bandarian, V; McCarty, RM2
Cikotiene, I; León, LG; Padrón, JM; Pudziuvelyte, E; Ríos-Luci, C1
Furutani, M; Hondo, T; Hoshii, H; Kontani, T; Kuromitsu, S; Maeda, J; Moritomo, A; Nagashima, S; Nagata, H; Ogiyama, T; Ohga, K; Ohno, K; Ohta, M; Orita, M; Shiozuka, K; Takeuchi, M; Tsukamoto, S1
Globisch, C; Pajeva, IK; Wiese, M1
de Courcy, B; Garbay, C; Gresh, N; Piquemal, JP1
Bencsik, JR; Blake, JF; Brandhuber, BJ; Gloor, SL; Gross, SD; Kallan, NC; Martinson, M; Mitchell, IS; Morales, TH; Risom, T; Skelton, NJ; Spencer, KL; Vigers, GP; Woessner, RD; Xiao, D; Xu, R1
Awazu, Y; Hori, A; Imamura, S; Iwata, H; Kamiyama, K; Miki, H; Miyamoto, N; Oguro, Y; Okada, K; Takagi, T1
Awazu, Y; Hori, A; Imamura, S; Kamiyama, K; Miki, H; Miyamoto, N; Oguro, Y; Okada, K; Takagi, T1
Chin, HF; De La Cruz, EM; Islam, K; Kapoor, TM; Olivares, AO; Saunders, LP1
Armstrong, JS; Hecht, SM; Khdour, OM; Lu, J1
Chai, SC; Im, W; Jo, S; Lee, JH; Lim, HS; Lu, H; Oh, M; Zhang, Q1
Bergqvist, S; Gajiwala, KS; Hickey, MJ; Huang, B; Kania, R; Kung, PP; Maegley, K; McClellan, G; Mehta, PP; Richardson, P; Sinnema, PJ; Wang, F; Wang, J1
Atapour-Mashhad, H; Davoodnia, A; Moloudi, R; Mousavi, SH; Tayarani-Najaran, Z1
Cagnotto, A; Mennini, T; Modica, MN; Pedretti, A; Pittalà, V; Romeo, G; Salerno, L; Siracusa, MA; Vistoli, G1
Jiang, YJ; Lu, SY; Wu, TX; Zou, JW1
Bjørkøy, G; Fuglseth, E; Hoff, BH; Kaspersen, SJ; Kjøbli, E; Sundby, E; Sørum, C; Willassen, V1
Chresta, CC; Cosulich, S; Crafter, C; Cross, D; Davies, BR; Dudley, P; Gao, B; Greenwood, H; Ji, Q; Lane, C; Li, J; Luke, R; Maynard, J; Ogilvie, D; Page, K; Pass, M; Ricketts, SA; Watson, R; Yates, J; Yu, DH; Zhang, J1
Bregman, H; Buchanan, JL; Chakka, N; Dimauro, EF; Du, B; Feric, E; Ligutti, J; Liu, D; McDermott, JS; McDonough, SI; Nguyen, HN; Zou, A1
El Kaïm, L; Grimaud, L; Pravin, P1
Cheng, N; Hu, W; Huang, M; Li, Z; Lu, X; Tu, Z; Xie, H; Xu, H; Yang, L; Zeng, L; Zeng, S; Zhang, G; Zhang, X; Zhao, J; Zhao, X1
Charnock, C; Hoff, BH; Kaspersen, SJ; Sundby, E1
Gupta, MK; Kumar, V; Prabhakar, YS; Singh, G1
Banno, H; Ikeda, Y; Ishikawa, T; Kamiguchi, H; Kamiyama, K; Kawakita, Y; Miki, H; Miwa, K; Ohta, Y; Seto, M; Tamura, T; Tanaka, T; Yusa, T1
Ebiike, H; Kawada, H; Morikami, K; Nakamura, M; Ogawa, K; Ohwada, J; Shimma, N; Tsukazaki, M; Tsukuda, T; Yoshida, M; Yoshinari, K1
Bensen, DC; Brown-Driver, V; Castellano, A; Chen, Z; Creighton, CJ; Cunningham, ML; Finn, J; Kwan, B; Lam, T; Li, X; Lightstone, FC; Nelson, K; Nguyen, TB; Shaw, KJ; Stidham, M; Tari, LW; Trzoss, M; Wong, SE; Zhang, J1
Bensen, DC; Chen, Z; Creighton, CJ; Cunningham, ML; Finn, J; Kwan, B; Lam, T; Li, X; Lightstone, FC; Nguyen, TB; Nix, J; Shaw, KJ; Stidham, M; Tari, LW; Trzoss, M; Wong, SE; Zhang, J1
Kim, JY; Lee, BH; Lim, CJ; Oh, KS; Yi, KY1
Bizzarri, M; Chelli, R; Frezzato, D; Gellini, C; Nicolini, P1
Hou, T; Li, D; Li, Y; Shen, M; Zhou, S1
Bursavich, MG; Cimbora, DM; Dastrup, D; Kumar, DV; Shenderovich, M; Williams, B; Yager, KM1
Gohda, K; Otsubo, T; Sueda, T; Teno, N; Tsuda, Y; Wanaka, K; Yamashita, Y1
El-Deeb, HS; El-Kousy, SM; Hilmy, KM; Shahin, EB; Soliman, DH1
Alsaid, MS; Ceruso, M; Ghorab, MM; Nissan, YM; Supuran, CT1
Abbott, BM; Brzozowski, M; Buskes, MJ; Deady, LW; O'Brien, NJ1
Rameshthangam, P; Srinivasan, P; Sudha, A1
Alsaid, MS; Arafa, RK; Ceruso, M; Ghorab, MM; Nissan, YM; Supuran, CT1
Abd El-Hameed, RH; Mohamed, MS; Sayed, AI; Soror, SH1
Akagawa, M; Akiduki, E; Araki, M; Gohda, K; Masuda, A; Otsubo, T; Teno, N; Tsuda, Y; Wanaka, K; Yamashita, Y1
Guo, H; Li, L; Liu, M; Liu, X; Wang, C; Wang, M; Wu, Z; Ye, C1
Balzarini, J; Cawrse, BM; Ross, CR; Seley-Radtke, KL; Temburnikar, KW; Wilson, GM1
Han, J; Hoff, BH; Kaspersen, SJ; Sundby, E1
Ebiike, H; Kawada, H; Koyama, K; Morikami, K; Nakamura, M; Ogawa, K; Ohwada, J; Shinma, N; Tsukazaki, M; Tsukuda, T; Yamamoto, S; Yoshida, M; Yoshinari, K1
De Coen, LM; García, D; Heugebaert, TS; Stevens, CV1
Choi, KW; Lee, CH; Oh, HL; Ryou, C; Suh, H1
Atienza, J; Dougan, DR; Hixon, MS; Kamran, R; Lawson, JD; Sabat, M; Scorah, N; Wang, H1
Cho, WJ; Choi, S; Chung, YK; Han, SY; Kang, KW; Kim, J; Kim, YC; Ko, H; Lee, HJ; Lee, SM; Mukai, C; Yoon, KB1
Schmitt, SM; Stefan, K; Wiese, M1
Argyros, O; Bach, S; Baratte, B; Christoforidis, S; Daniilides, K; Evangelidis, T; Karamani, V; Kostakis, IK; Kouvari, E; Lougiakis, N; Marakos, P; Mikros, E; Papafotika, A; Pouli, N; Ruchaud, S; Skaltsounis, AL; Tamvakopoulos, C1
Golkowski, M; Lombard, CK; Maly, DJ; Ong, SE; Suh, HW; Vidadala, RS1
Fischer, T; Hilgeroth, A; Krüger, T; Najjar, A; Ritter, C; Schächtele, C; Sippl, W; Totzke, F1
Beauvineau, C; Busser, B; Coll, JL; Falson, P; Fernando Díaz, J; Frachet, V; Gilson, P; Hurbin, A; Josa-Prado, F; Lafanechère, L; Mahuteau-Betzer, F; Moreno, A; Naud-Martin, D; Vanwonterghem, L1
Georg, GI; Hawkinson, JE; Herr, JC; Mudaliar, D; Shetty, J; Sinville, R; Ward, T1
Anjum, R; Culshaw, J; Davies, NL; Davies, RDM; Degorce, SL; Dillman, KS; Dowling, JE; Drew, L; Ferguson, AD; Groombridge, SD; Halsall, CT; Hudson, JA; Lamont, S; Lindsay, NA; Marden, SK; Mayo, MF; McWhirter, C; Pease, JE; Perkins, DR; Pink, JH; Robb, GR; Rosen, A; Scott, JS; Shen, M; Wu, D1
Abouzid, KAM; Adel, M; Lasheen, DS; Serya, RAT2
Arnold, SLM; Barrett, LK; Choi, R; Fan, E; Golkowski, M; Huang, W; Hulverson, MA; Maly, DJ; McCloskey, MC; Merritt, EA; Ojo, KK; Van Voorhis, WC; Vidadala, RSR; Whitman, GR1
Cardenas, MM; Gustafson, JL; Nalbandian, CJ; Toenjes, ST1
Duan, Y; Li, X; Liu, X; Tang, Q; Wang, C; Wang, L; Xiao, Z; Zhao, B; Zheng, P; Zhu, W1
Abd-El Hameed, RH; Fatahala, SS; Mahgub, S; Taha, H1
Belashov, IA; Dutta, D; Wedekind, JE1
Pathania, S; Rawal, RK1
Couté, Y; Hahn, F; Hamilton, ST; Henry, C; Hutterer, C; Kohrt, S; Kraut, A; Marschall, M; Pfizer, J; Rawlinson, WD; Schulte, U; Schütz, M; Strobl, S; Strojan, H; Wangen, C1
Belashov, IA; Ermolenko, DN; Ling, C; Salim, M; Warnasooriya, C; Wedekind, JE1
Khedr, MA; Mohamed, MS; Nofal, S; Sayed, AI; Soror, SH1
Bommu, UD; Konidala, KK; Pabbaraju, N1
Choi, H; Kim, YH; Lee, GS; Lee, SB; Shin, HJ1
Akter, M; Debono, CO; Devine, SM; Drew, SC; Drinkwater, N; Krishnarjuna, B; MacRaild, CA; McGowan, S; Norton, RS; Scammells, PJ; Scanlon, MJ; Wang, G1
Camarasa, MJ; Carriles, AA; de Lucio, H; Gago, F; Gamo, A; Gutiérrez, KJ; Hermoso, JA; Jiménez-Ruiz, A; Revuelto, A; Ruiz-Santaquiteria, M; Sánchez-Murcia, PA; Velázquez, S1
Chen, X; Guo, K; Liu, Y; Ran, F; Zhang, Z; Zhao, G1
Dou, W; Guo, J; Hu, W; Huang, H; Li, M; Ma, Y; Xie, H; Zeng, S; Zhao, N; Zhao, X; Zhou, Q; Zhou, Y1
Luzhetskyy, A; Myronovskyi, M; Nadmid, S; Shuai, H1
Aka, Y; Kilic-Kurt, Z; Kutuk, O1
Bauer, S; Baumann, M; Becker, C; Grabe, T; Hardick, J; Hodson, L; Jeyakumar, K; Ketzer, J; Keul, M; Kirschner, T; Klövekorn, P; Lategahn, J; Müller, MP; Niggenaber, J; Rauh, D; Terheyden, S; Tumbrink, HL; Unger, A; van Otterlo, WAL; Weisner, J1
Chung, SH; Jung, D; Lee, JW; Min, KH; Park, J; Song, J1
Barrett, LK; Choi, R; Hulverson, MA; Kempf, DJ; Lynch, JJ; Maly, DJ; Marsh, K; Ojo, KK; Van Voorhis, WC; Vidadala, RSR; Vidadala, VN; Whitman, GR1
Chen, X; Duan, X; Li, Y; Liu, Y; Ran, F; Xu, C; Zhao, G; Zhuo, H1
Backos, DS; Casalvieri, KA; Matheson, CJ; Reigan, P; Warfield, BM1
Jeong, PH; Jung, JH; Kim, W; Kim, YC; Lee, SM1
Aubé, J; Baljinnyam, B; Bryant-Connah, M; Davis, D; De, S; Dextras, C; Dutta, D; Ferrer, M; Frankowski, KJ; Henderson, MJ; Huang, S; Jadhav, A; Kabir, M; Li, D; Lin, YH; Marugan, JJ; Mathews Griner, LA; Norton, J; Patnaik, S; Rudloff, U; Schoenen, FJ; Shah, P; Simeonov, A; Southall, N; Titus, S; Wachsmuth, LM; Wang, A; Wang, C; Wang, F; Williams, J; Xu, X; Zheng, W; Zhu, E1
Abd El-Hameed, RH; Ali, MA; Aly, O; Fatahala, SS; Khoder, ZM; Mansour, YE; Said, AM; Sayed, AI1
Chen, X; Hao, M; Hu, J; Jiang, H; Jin, J; Liu, X; Sun, H; Wang, X; Yang, M; Yang, Z1
Boyce, CW; Bungard, CJ; Dartois, V; Dick, T; El Marrouni, A; Gengenbacher, M; Madani, A; Miller, RR; Murgolo, N; Negatu, DA; Olsen, DB; Zimmerman, MD1
Choo, H; Chung, HW; Han, SJ; Jeong, HJ; Jeong, JH; Ji, SH; Kang, M; Kim, HB; Kim, NJ; Kim, SJ; Lee, DH; Lee, HL; Lee, SH; Park, CS; Yoon, HJ1
Bernier, L; Chen, H; Cho-Schultz, S; Chung, L; Collins, M; Costa Jones, C; Cronin, CN; Del Bel, M; Edwards, M; Elleraas, J; Fang, X; Fisher, T; Gallego, RA; He, M; Hoffman, J; Huo, R; Jalaie, M; Johnson, E; Johnson, TW; Kania, RS; Kraus, M; Lafontaine, J; Le, P; Liu, T; Maestre, M; Matthews, J; McTigue, M; Miller, N; Mu, Q; Nair, SK; Qin, X; Ren, S; Richardson, P; Rohner, A; Sach, N; Shao, L; Smith, G; Su, R; Sun, B; Timofeevski, S; Tran, P; Wang, S; Wang, W; Zhou, R; Zhu, J1
Cui, M; Feng, P; Gu, J; Guo, R; Huo, S; Li, X; Liu, Y; Luo, Z; Shi, X; Wang, C; Wang, J; Wang, L; Wu, M; Xing, R; Xu, F; Zhang, Y1

Reviews

4 review(s) available for pyrroles and pyrrolopyrimidine

ArticleYear
Biosynthesis of pyrrolopyrimidines.
    Bioorganic chemistry, 2012, Volume: 43

    Topics: Enzymes; Guanosine; Nucleoside Q; Purines; Pyrimidines; Pyrroles; RNA, Transfer

2012
Synthetic Entries to and Biological Activity of Pyrrolopyrimidines.
    Chemical reviews, 2016, Jan-13, Volume: 116, Issue:1

    Topics: Animals; Chemistry Techniques, Synthetic; Drug Discovery; Humans; Models, Molecular; Pyrimidines; Pyrroles

2016
Pyrrolopyrimidine, A Multifaceted Scaffold in Cancer Targeted Therapy.
    Drug research, 2018, Volume: 68, Issue:9

    Topics: Antineoplastic Agents; Drug Design; Humans; Molecular Targeted Therapy; Neoplasms; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Structure-Activity Relationship

2018
Pyrrolopyrimidines: An update on recent advancements in their medicinal attributes.
    European journal of medicinal chemistry, 2018, Sep-05, Volume: 157

    Topics: Animals; Anti-Retroviral Agents; Antineoplastic Agents; HIV Infections; Humans; Male; Molecular Structure; Prostatic Neoplasms; Protein Kinase Inhibitors; Protein Kinases; Pyrimidines; Pyrroles; Structure-Activity Relationship

2018

Trials

1 trial(s) available for pyrroles and pyrrolopyrimidine

ArticleYear
Preclinical pharmacology of AZD5363, an inhibitor of AKT: pharmacodynamics, antitumor activity, and correlation of monotherapy activity with genetic background.
    Molecular cancer therapeutics, 2012, Volume: 11, Issue:4

    Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Female; Humans; Male; Mice; Mice, Nude; Mice, SCID; Prostatic Neoplasms; Proto-Oncogene Proteins c-akt; Pyrimidines; Pyrroles; Signal Transduction; Xenograft Model Antitumor Assays

2012

Other Studies

83 other study(ies) available for pyrroles and pyrrolopyrimidine

ArticleYear
Novel scaffold for cathepsin K inhibitors.
    Bioorganic & medicinal chemistry letters, 2007, Nov-15, Volume: 17, Issue:22

    Topics: Cathepsin K; Cathepsins; Humans; Inhibitory Concentration 50; Molecular Structure; Pyrimidines; Pyrroles; Recombinant Proteins; Structure-Activity Relationship

2007
Effect of cathepsin K inhibitors on bone resorption.
    Journal of medicinal chemistry, 2008, Sep-11, Volume: 51, Issue:17

    Topics: Animals; Bone Marrow; Bone Resorption; Cathepsin K; Cathepsins; Collagen Type I; Cysteine Proteinase Inhibitors; Haplorhini; Pyrimidines; Pyrroles; Rats; Spiro Compounds; Tissue Distribution

2008
Deciphering deazapurine biosynthesis: pathway for pyrrolopyrimidine nucleosides toyocamycin and sangivamycin.
    Chemistry & biology, 2008, Aug-25, Volume: 15, Issue:8

    Topics: Amino Acid Sequence; Anti-Bacterial Agents; Gene Expression Regulation, Bacterial; GTP Cyclohydrolase; Hydro-Lyases; Molecular Sequence Data; Multigene Family; Purines; Pyrimidine Nucleosides; Pyrimidines; Pyrroles; Streptomyces; Toyocamycin

2008
Synthesis and antiproliferative activity of 2,4-disubstituted 6-aryl-7H-pyrrolo[3,2-d]pyrimidin-7-one 5-oxides.
    Bioorganic & medicinal chemistry, 2009, Jul-15, Volume: 17, Issue:14

    Topics: Antineoplastic Agents; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Lung Neoplasms; Oxides; Pyrimidines; Pyrroles

2009
Novel 7H-pyrrolo[2,3-d]pyrimidine derivatives as potent and orally active STAT6 inhibitors.
    Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19

    Topics: Administration, Oral; Animals; Asthma; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Eosinophils; Humans; Immunity; Mice; Pyrimidines; Pyrroles; STAT6 Transcription Factor; Structure-Activity Relationship; Th2 Cells

2009
Combined pharmacophore modeling, docking, and 3D QSAR studies of ABCB1 and ABCC1 transporter inhibitors.
    ChemMedChem, 2009, Volume: 4, Issue:11

    Topics: ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Computer Simulation; Humans; Indoles; Models, Chemical; Multidrug Resistance-Associated Proteins; Pyrimidines; Pyrroles; Quantitative Structure-Activity Relationship; Quinazolinones

2009
Polarizable water molecules in ligand-macromolecule recognition. Impact on the relative affinities of competing pyrrolopyrimidine inhibitors for FAK kinase.
    Journal of the American Chemical Society, 2010, Mar-17, Volume: 132, Issue:10

    Topics: Binding Sites; Focal Adhesion Protein-Tyrosine Kinases; Ligands; Macromolecular Substances; Models, Molecular; Pyrimidines; Pyrroles; Thermodynamics; Water

2010
Discovery of pyrrolopyrimidine inhibitors of Akt.
    Bioorganic & medicinal chemistry letters, 2010, Oct-01, Volume: 20, Issue:19

    Topics: Adaptor Proteins, Signal Transducing; Animals; Binding Sites; Cell Line; Crystallography, X-Ray; Drug Design; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Humans; Mice; Phosphoproteins; Protein Isoforms; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Pyrimidines; Pyrroles; Structure-Activity Relationship; Xenograft Model Antitumor Assays

2010
Design, synthesis, and evaluation of 5-methyl-4-phenoxy-5H-pyrrolo[3,2-d]pyrimidine derivatives: novel VEGFR2 kinase inhibitors binding to inactive kinase conformation.
    Bioorganic & medicinal chemistry, 2010, Oct-15, Volume: 18, Issue:20

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Crystallography, X-Ray; Drug Design; Humans; Mice; Mice, Nude; Phenylurea Compounds; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Pyrimidines; Pyrroles; Receptor, TIE-2; Vascular Endothelial Growth Factor Receptor-2; Xenograft Model Antitumor Assays

2010
N-phenyl-N'-[4-(5H-pyrrolo[3,2-d]pyrimidin-4-yloxy)phenyl]ureas as novel inhibitors of VEGFR and FGFR kinases.
    Bioorganic & medicinal chemistry, 2010, Oct-15, Volume: 18, Issue:20

    Topics: Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Computer Simulation; Crystallography, X-Ray; Drug Design; Humans; Phenylurea Compounds; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Receptor, TIE-2; Receptors, Fibroblast Growth Factor; Receptors, Platelet-Derived Growth Factor; Receptors, Vascular Endothelial Growth Factor; Structure-Activity Relationship; Urea

2010
A myosin V inhibitor based on privileged chemical scaffolds.
    Angewandte Chemie (International ed. in English), 2010, Nov-02, Volume: 49, Issue:45

    Topics: Animals; Enzyme Inhibitors; Humans; Indoles; Kinetics; Mice; Myosin Type V; Oxindoles; Pyrazoles; Pyridines; Pyrimidines; Pyrroles; Structure-Activity Relationship

2010
Design, synthesis, and evaluation of an α-tocopherol analogue as a mitochondrial antioxidant.
    Bioorganic & medicinal chemistry, 2010, Nov-01, Volume: 18, Issue:21

    Topics: alpha-Tocopherol; Animals; Antioxidants; Cattle; Cell Membrane; Diterpenes; Drug Design; Lipid Peroxidation; Mitochondria; Pyridines; Pyrimidines; Pyrroles; Reactive Oxygen Species

2010
Novel pyrrolopyrimidine-based α-helix mimetics: cell-permeable inhibitors of protein−protein interactions.
    Journal of the American Chemical Society, 2011, Feb-02, Volume: 133, Issue:4

    Topics: Amino Acid Sequence; Biomimetic Materials; Cell Line, Tumor; Drug Design; High-Throughput Screening Assays; Humans; Models, Molecular; Permeability; Protein Binding; Protein Structure, Secondary; Proto-Oncogene Proteins c-mdm2; Pyrimidines; Pyrroles; Tumor Suppressor Protein p53

2011
Design strategies to target crystallographic waters applied to the Hsp90 molecular chaperone.
    Bioorganic & medicinal chemistry letters, 2011, Jun-15, Volume: 21, Issue:12

    Topics: Binding Sites; Crystallography, X-Ray; Drug Design; HSP90 Heat-Shock Proteins; Humans; Inhibitory Concentration 50; Models, Molecular; Molecular Structure; Pyrimidines; Pyrroles; Small Molecule Libraries

2011
Antitumor activity of novel pyrrolo[2,3-d]pyrimidin-4-ones.
    Drug and chemical toxicology, 2011, Volume: 34, Issue:3

    Topics: Antineoplastic Agents; Apoptosis; Cell Culture Techniques; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Flow Cytometry; Humans; Microscopy, Fluorescence; Molecular Structure; Pyrimidines; Pyrroles; Structure-Activity Relationship

2011
Synthesis and molecular modeling of 1H-pyrrolopyrimidine-2,4-dione derivatives as ligands for the α1-adrenoceptors.
    Bioorganic & medicinal chemistry, 2011, Sep-01, Volume: 19, Issue:17

    Topics: Animals; Binding Sites; Computer Simulation; Humans; Ligands; Microwaves; Models, Molecular; Pyrimidines; Pyrroles; Rats; Receptor, Serotonin, 5-HT1A; Receptors, Adrenergic, alpha-1; Structure-Activity Relationship

2011
Molecular modeling and molecular dynamics simulation studies on pyrrolopyrimidine-based α-helix mimetic as dual inhibitors of MDM2 and MDMX.
    Journal of molecular graphics & modelling, 2011, Volume: 30

    Topics: Catalytic Domain; Cell Cycle Proteins; Humans; Molecular Dynamics Simulation; Nuclear Proteins; Protein Binding; Protein Structure, Secondary; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-mdm2; Pyrimidines; Pyrroles; Surface Properties; Thermodynamics

2011
Synthesis and in vitro EGFR (ErbB1) tyrosine kinase inhibitory activity of 4-N-substituted 6-aryl-7H-pyrrolo[2,3-d]pyrimidine-4-amines.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:12

    Topics: Antineoplastic Agents; ErbB Receptors; HeLa Cells; Humans; Models, Molecular; Neoplasms; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Structure-Activity Relationship

2011
Discovery and hit-to-lead optimization of pyrrolopyrimidines as potent, state-dependent Na(v)1.7 antagonists.
    Bioorganic & medicinal chemistry letters, 2012, Mar-01, Volume: 22, Issue:5

    Topics: Drug Discovery; Humans; Microsomes, Liver; NAV1.7 Voltage-Gated Sodium Channel; Pain; Pyrimidines; Pyrroles; Sodium Channel Blockers; Sodium Channels; Structure-Activity Relationship

2012
Xanthate based radical cascade toward multicomponent formation of pyrrolopyrimidines.
    Molecules (Basel, Switzerland), 2011, Volume: 16, Issue:11

    Topics: Chemistry Techniques, Synthetic; Cyclization; Heterocyclic Compounds; Molecular Structure; Pyrimidines; Pyrroles; Thiones

2011
Novel pyrrolopyrimidine analogues as potent dipeptidyl peptidase IV inhibitors based on pharmacokinetic property-driven optimization.
    European journal of medicinal chemistry, 2012, Volume: 52

    Topics: Absorption; Animals; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Drug Design; Drug Stability; Hypoglycemic Agents; Inhibitory Concentration 50; Mice; Pyrimidines; Pyrroles

2012
Activity of 6-aryl-pyrrolo[2,3-d]pyrimidine-4-amines to Tetrahymena.
    Bioorganic chemistry, 2012, Volume: 44

    Topics: Amination; Antiprotozoal Agents; Ciliophora Infections; Humans; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Tetrahymena

2012
Modeling of LIM-Kinase 2 inhibitory activity of pyrrolopyrimidine analogues: useful in treatment of ocular hypertension and glaucoma.
    Medicinal chemistry (Shariqah (United Arab Emirates)), 2013, Volume: 9, Issue:3

    Topics: Combinatorial Chemistry Techniques; Glaucoma; Least-Squares Analysis; Lim Kinases; Linear Models; Models, Biological; Ocular Hypertension; Pyrimidines; Pyrroles

2013
Design and synthesis of pyrrolo[3,2-d]pyrimidine HER2/EGFR dual inhibitors: improvement of the physicochemical and pharmacokinetic profiles for potent in vivo anti-tumor efficacy.
    Bioorganic & medicinal chemistry, 2012, Oct-15, Volume: 20, Issue:20

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Design; ErbB Receptors; Half-Life; Humans; Mice; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Rats; Receptor, ErbB-2; Stomach Neoplasms; Sulfones; Transplantation, Heterologous

2012
Lead optimization of a dihydropyrrolopyrimidine inhibitor against phosphoinositide 3-kinase (PI3K) to improve the phenol glucuronic acid conjugation.
    Bioorganic & medicinal chemistry letters, 2013, Feb-01, Volume: 23, Issue:3

    Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Crystallography, X-Ray; Enzyme Activation; Female; Glucuronic Acid; Humans; Hydrogen Bonding; Inhibitory Concentration 50; Mice; Molecular Structure; Phenols; Phosphoinositide-3 Kinase Inhibitors; Pyrimidines; Pyrroles; Structure-Activity Relationship; Xenograft Model Antitumor Assays

2013
Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE), Part II: development of inhibitors with broad spectrum, Gram-negative antibacterial activity.
    Bioorganic & medicinal chemistry letters, 2013, Mar-01, Volume: 23, Issue:5

    Topics: Anti-Bacterial Agents; DNA Gyrase; DNA Topoisomerase IV; Drug Design; Humans; Pyrimidines; Pyrroles; Structure-Activity Relationship; Topoisomerase II Inhibitors

2013
Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.
    Bioorganic & medicinal chemistry letters, 2013, Mar-01, Volume: 23, Issue:5

    Topics: Anti-Bacterial Agents; DNA Gyrase; DNA Topoisomerase IV; Drug Design; Models, Molecular; Pyrimidines; Pyrroles; Structure-Activity Relationship; Topoisomerase II Inhibitors

2013
Synthesis and SAR study of pyrrolo[3,4-b]pyridin-7(6H)-one derivatives as melanin concentrating hormone receptor 1 (MCH-R1) antagonists.
    Bioorganic & medicinal chemistry letters, 2013, Mar-15, Volume: 23, Issue:6

    Topics: Animals; Anti-Obesity Agents; Half-Life; Humans; Obesity; Protein Binding; Pyridines; Pyrimidines; Pyrroles; Pyrrolidinones; Rats; Receptors, Pituitary Hormone; Structure-Activity Relationship

2013
Toward quantitative estimates of binding affinities for protein-ligand systems involving large inhibitor compounds: a steered molecular dynamics simulation route.
    Journal of computational chemistry, 2013, Jul-05, Volume: 34, Issue:18

    Topics: Antineoplastic Agents; Binding Sites; Enzyme Inhibitors; Focal Adhesion Protein-Tyrosine Kinases; Ligands; Molecular Dynamics Simulation; Pyrimidines; Pyrroles; Structure-Activity Relationship

2013
Theoretical study on the interaction of pyrrolopyrimidine derivatives as LIMK2 inhibitors: insight into structure-based inhibitor design.
    Molecular bioSystems, 2013, Volume: 9, Issue:10

    Topics: Drug Design; Inhibitory Concentration 50; Kinetics; Lim Kinases; Models, Molecular; Molecular Conformation; Molecular Docking Simulation; Molecular Dynamics Simulation; Protein Binding; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Quantitative Structure-Activity Relationship

2013
Novel Mps1 kinase inhibitors: from purine to pyrrolopyrimidine and quinazoline leads.
    Bioorganic & medicinal chemistry letters, 2013, Dec-15, Volume: 23, Issue:24

    Topics: Cell Cycle Proteins; Cell Proliferation; Drug Design; HCT116 Cells; Humans; Models, Molecular; Protein Binding; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Purines; Pyrimidines; Pyrroles; Quinazolines; Structure-Activity Relationship

2013
Pyrrolopyrimidine-inhibitors with hydantoin moiety as spacer can explore P4/S4 interaction on plasmin.
    Bioorganic & medicinal chemistry, 2014, Apr-01, Volume: 22, Issue:7

    Topics: Antifibrinolytic Agents; Dose-Response Relationship, Drug; Fibrinolysin; Models, Molecular; Molecular Structure; Pyrimidines; Pyrroles; Structure-Activity Relationship

2014
Design, synthesis and evaluation of novel diaryl pyrrolopyrimidine and pyrrolothiazine derivatives as inhibitors of tumor necrosis factor stimulated gene-14 (TSG-14) production.
    European journal of medicinal chemistry, 2014, May-06, Volume: 78

    Topics: Animals; C-Reactive Protein; Dose-Response Relationship, Drug; Drug Design; Lipopolysaccharides; Male; Molecular Structure; Pyrimidines; Pyrroles; Rats; Serum Amyloid P-Component; Structure-Activity Relationship; Thiazines

2014
Carbonic anhydrase inhibitors: Synthesis, molecular docking, cytotoxic and inhibition of the human carbonic anhydrase isoforms I, II, IX, XII with novel benzenesulfonamides incorporating pyrrole, pyrrolopyrimidine and fused pyrrolopyrimidine moieties.
    Bioorganic & medicinal chemistry, 2014, Jul-15, Volume: 22, Issue:14

    Topics: Benzenesulfonamides; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Isoenzymes; Molecular Structure; Pyrimidines; Pyrroles; Structure-Activity Relationship; Sulfonamides

2014
Synthesis and biological evaluation of 2-anilino-4-substituted-7H-pyrrolopyrimidines as PDK1 inhibitors.
    Bioorganic & medicinal chemistry, 2014, Aug-01, Volume: 22, Issue:15

    Topics: Humans; Protein Binding; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrimidines; Pyrroles; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Structure-Activity Relationship

2014
Exploration of potential EGFR inhibitors: a combination of pharmacophore-based virtual screening, atom-based 3D-QSAR and molecular docking analysis.
    Journal of receptor and signal transduction research, 2015, Volume: 35, Issue:2

    Topics: Antineoplastic Agents; Binding Sites; ErbB Receptors; Humans; Molecular Docking Simulation; Neoplasms; Protein Binding; Pyrimidines; Pyrroles; Quantitative Structure-Activity Relationship; User-Computer Interface

2015
Novel sulfonamides bearing pyrrole and pyrrolopyrimidine moieties as carbonic anhydrase inhibitors: Synthesis, cytotoxic activity and molecular modeling.
    European journal of medicinal chemistry, 2014, Nov-24, Volume: 87

    Topics: Antigens, Neoplasm; Antineoplastic Agents; Breast Neoplasms; Carbonic Anhydrase I; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase IX; Carbonic Anhydrases; Cell Proliferation; Drug Screening Assays, Antitumor; Female; Flow Cytometry; Humans; Models, Molecular; Molecular Structure; Pyrimidines; Pyrroles; Structure-Activity Relationship; Sulfonamides; Tumor Cells, Cultured

2014
Novel antiviral compounds against gastroenteric viral infections.
    Archiv der Pharmazie, 2015, Volume: 348, Issue:3

    Topics: Adenoviridae; Antiviral Agents; Cell Survival; Dose-Response Relationship, Drug; Drug Design; Enterovirus B, Human; Gastroenteritis; Hep G2 Cells; Humans; Molecular Structure; Pyrimidines; Pyrroles; Rotavirus; Structure-Activity Relationship

2015
Novel type of plasmin inhibitors: providing insight into P4 moiety and alternative scaffold to pyrrolopyrimidine.
    Bioorganic & medicinal chemistry, 2015, Jul-01, Volume: 23, Issue:13

    Topics: Antifibrinolytic Agents; Benzimidazoles; Catalytic Domain; Fibrinolysin; Fibrinolytic Agents; Humans; Molecular Docking Simulation; Molecular Structure; Pyrimidines; Pyrroles; Structure-Activity Relationship

2015
Synthesis and antitumor activity of 5-(5-halogenated-2-oxo-1H-pyrrolo[2,3-b]pyridin-(3Z)-ylidenemethyl)-2,4-dimethyl-1H-pyrrole-3-carboxamides.
    Bioorganic & medicinal chemistry letters, 2015, Jul-15, Volume: 25, Issue:14

    Topics: Amides; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Indoles; MCF-7 Cells; Pyrimidines; Pyrroles; Structure-Activity Relationship; Sunitinib

2015
Antiproliferative activities of halogenated pyrrolo[3,2-d]pyrimidines.
    Bioorganic & medicinal chemistry, 2015, Aug-01, Volume: 23, Issue:15

    Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; G2 Phase Cell Cycle Checkpoints; Halogenation; Humans; M Phase Cell Cycle Checkpoints; Pyrimidines; Pyrroles; Structure-Activity Relationship

2015
In vitro baselining of new pyrrolopyrimidine EGFR-TK inhibitors with Erlotinib.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2015, Dec-01, Volume: 80

    Topics: Antineoplastic Agents; Breast Neoplasms; Caco-2 Cells; Cell Line, Tumor; Cell Proliferation; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; ErbB Receptors; Erlotinib Hydrochloride; Female; Humans; In Vitro Techniques; Lung Neoplasms; Ovarian Neoplasms; Pyrimidines; Pyrroles

2015
Modification of a dihydropyrrolopyrimidine phosphoinositide 3-kinase (PI3K) inhibitor to improve oral bioavailability.
    Bioorganic & medicinal chemistry, 2015, Dec-15, Volume: 23, Issue:24

    Topics: Administration, Oral; Animals; Biological Availability; Female; Humans; Macaca fascicularis; Male; Mice, Inbred BALB C; Microsomes, Liver; Permeability; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Solubility

2015
p21CIP1 Induces Apoptosis via Binding to BCL2 in LNCaP Prostate Cancer Cells Treated with MCS-C3, A Novel Carbocyclic Analog of Pyrrolopyrimidine.
    Anticancer research, 2016, Volume: 36, Issue:1

    Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Humans; Male; Prostatic Neoplasms; Proto-Oncogene Proteins c-bcl-2; Pyrimidines; Pyrroles; Signal Transduction; Transfection

2016
Design, synthesis and optimization of novel Alk5 (activin-like kinase 5) inhibitors.
    Bioorganic & medicinal chemistry letters, 2016, 09-01, Volume: 26, Issue:17

    Topics: Animals; Cyclization; Drug Design; Enzyme Activation; Enzyme Inhibitors; Humans; Indoles; Inhibitory Concentration 50; Molecular Structure; Protein Serine-Threonine Kinases; Pyrimidines; Pyrroles; Rats; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta

2016
The discovery of 2,5-isomers of triazole-pyrrolopyrimidine as selective Janus kinase 2 (JAK2) inhibitors versus JAK1 and JAK3.
    Bioorganic & medicinal chemistry, 2016, 11-01, Volume: 24, Issue:21

    Topics: Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Discovery; Humans; Janus Kinase 1; Janus Kinase 2; Janus Kinase 3; Molecular Structure; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Stereoisomerism; Structure-Activity Relationship; Triazoles

2016
Pyrrolopyrimidine derivatives and purine analogs as novel activators of Multidrug Resistance-associated Protein 1 (MRP1, ABCC1).
    Biochimica et biophysica acta. Biomembranes, 2017, Volume: 1859, Issue:1

    Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; Cell Line, Tumor; Daunorubicin; Dogs; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Fluoresceins; Fluorescent Dyes; Gene Expression; Humans; Kinetics; Madin Darby Canine Kidney Cells; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Purines; Pyrimidines; Pyrroles; Structure-Activity Relationship

2017
Discovery of New Aminosubstituted Pyrrolopyrimidines with Antiproliferative Activity Against Breast Cancer Cells and Investigation of their Effect Towards the PI3Kα Enzyme.
    Anti-cancer agents in medicinal chemistry, 2017, Volume: 17, Issue:7

    Topics: Amination; Antineoplastic Agents; Breast; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Class I Phosphatidylinositol 3-Kinases; Drug Design; Drug Screening Assays, Antitumor; Female; Humans; Male; Molecular Docking Simulation; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Prostate; Prostatic Neoplasms; Protein Kinase Inhibitors; Pyrimidines; Pyrroles

2017
Kinobead and Single-Shot LC-MS Profiling Identifies Selective PKD Inhibitors.
    Journal of proteome research, 2017, 03-03, Volume: 16, Issue:3

    Topics: Antineoplastic Agents; Binding, Competitive; Cell Line, Tumor; Chromatography, Liquid; Humans; Mass Spectrometry; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Proteomics; Pyrimidines; Pyrroles; Subcellular Fractions

2017
Discovery of novel substituted benzo-anellated 4-benzylamino pyrrolopyrimidines as dual EGFR and VEGFR2 inhibitors.
    Bioorganic & medicinal chemistry letters, 2017, 06-15, Volume: 27, Issue:12

    Topics: Antineoplastic Agents; Cell Proliferation; Dose-Response Relationship, Drug; Drug Discovery; Drug Screening Assays, Antitumor; ErbB Receptors; Humans; Molecular Docking Simulation; Molecular Structure; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Structure-Activity Relationship; Vascular Endothelial Growth Factor Receptor-2

2017
Identification of pyrrolopyrimidine derivative PP-13 as a novel microtubule-destabilizing agent with promising anticancer properties.
    Scientific reports, 2017, 08-31, Volume: 7, Issue:1

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chick Embryo; Colchicine; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Neoplasms, Experimental; Pyrimidines; Pyrroles; Tubulin; Tubulin Modulators; Xenograft Model Antitumor Assays

2017
Potent Pyrimidine and Pyrrolopyrimidine Inhibitors of Testis-Specific Serine/Threonine Kinase 2 (TSSK2).
    ChemMedChem, 2017, 11-22, Volume: 12, Issue:22

    Topics: Dose-Response Relationship, Drug; High-Throughput Screening Assays; Humans; Molecular Structure; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrimidines; Pyrroles; Structure-Activity Relationship

2017
Discovery and Optimization of Pyrrolopyrimidine Inhibitors of Interleukin-1 Receptor Associated Kinase 4 (IRAK4) for the Treatment of Mutant MYD88
    Journal of medicinal chemistry, 2017, 12-28, Volume: 60, Issue:24

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Cell Line, Tumor; Crystallography, X-Ray; Dogs; Female; Humans; Interleukin-1 Receptor-Associated Kinases; Lymphoma, Large B-Cell, Diffuse; Magnetic Resonance Spectroscopy; Male; Mice, SCID; Mutation; Myeloid Differentiation Factor 88; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Rats, Wistar; Structure-Activity Relationship; Xenograft Model Antitumor Assays

2017
7 H-Pyrrolo[2,3- d]pyrimidin-4-amine-Based Inhibitors of Calcium-Dependent Protein Kinase 1 Have Distinct Inhibitory and Oral Pharmacokinetic Characteristics Compared with 1 H-Pyrazolo[3,4- d]pyrimidin-4-amine-Based Inhibitors.
    ACS infectious diseases, 2018, 04-13, Volume: 4, Issue:4

    Topics: Animals; Antiprotozoal Agents; Cell Line; Cell Survival; Cryptosporidium parvum; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Mice, Inbred BALB C; Molecular Structure; Protein Kinases; Pyrimidines; Pyrroles; Structure-Activity Relationship

2018
Enantioselective Synthesis of Pyrrolopyrimidine Scaffolds through Cation-Directed Nucleophilic Aromatic Substitution.
    Organic letters, 2018, 04-06, Volume: 20, Issue:7

    Topics: Catalysis; Cations; Molecular Structure; Pyrimidines; Pyrroles; Stereoisomerism

2018
Discovery of novel pyrrolopyrimidine/pyrazolopyrimidine derivatives bearing 1,2,3-triazole moiety as c-Met kinase inhibitors.
    Chemical biology & drug design, 2018, Volume: 92, Issue:1

    Topics: Antineoplastic Agents; Binding Sites; Cell Line, Tumor; Cell Survival; Drug Design; Drug Screening Assays, Antitumor; G2 Phase Cell Cycle Checkpoints; Hep G2 Cells; Humans; M Phase Cell Cycle Checkpoints; MCF-7 Cells; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-met; Pyrazoles; Pyridines; Pyrimidines; Pyrroles; Structure-Activity Relationship; Triazoles

2018
Synthesis and evaluation of novel spiro derivatives for pyrrolopyrimidines as anti-hyperglycemia promising compounds.
    Journal of enzyme inhibition and medicinal chemistry, 2018, Volume: 33, Issue:1

    Topics: Animals; Blood Glucose; Cyclization; Diabetes Mellitus, Experimental; Glucose Tolerance Test; Hypoglycemic Agents; Male; Proton Magnetic Resonance Spectroscopy; Pyrimidines; Pyrroles; Rats, Wistar; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Infrared; Spiro Compounds; Streptozocin

2018
Coupling Green Fluorescent Protein Expression with Chemical Modification to Probe Functionally Relevant Riboswitch Conformations in Live Bacteria.
    Biochemistry, 2018, 08-07, Volume: 57, Issue:31

    Topics: Escherichia coli; Green Fluorescent Proteins; Lacticaseibacillus rhamnosus; Pyrimidines; Pyrroles; Riboswitch

2018
Identification of new pyrrolo[2,3-d]pyrimidines as potent VEGFR-2 tyrosine kinase inhibitors: Design, synthesis, biological evaluation and molecular modeling.
    Bioorganic chemistry, 2018, Volume: 81

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Drug Design; Human Umbilical Vein Endothelial Cells; Humans; Models, Molecular; Neoplasms; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Urea; Vascular Endothelial Growth Factor Receptor-2

2018
Novel cytomegalovirus-inhibitory compounds of the class pyrrolopyridines show a complex pattern of target binding that suggests an unusual mechanism of antiviral activity.
    Antiviral research, 2018, Volume: 159

    Topics: Adenoviridae; Antiviral Agents; Cytomegalovirus; Drug Discovery; Drug Resistance, Viral; Fibroblasts; Herpesviridae; Humans; Mass Spectrometry; Orthomyxoviridae; Pyrimidines; Pyrroles; Viral Proteins; Virus Replication

2018
Observation of preQ
    RNA biology, 2019, Volume: 16, Issue:9

    Topics: Fluorescence Resonance Energy Transfer; Magnesium; Nucleic Acid Conformation; Nucleoside Q; Pyrimidines; Pyrimidinones; Pyrroles; Riboswitch; RNA, Transfer; Single Molecule Imaging

2019
Evaluation of novel pyrrolopyrimidine derivatives as antiviral against gastroenteric viral infections.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2019, Jan-15, Volume: 127

    Topics: Animals; Antiviral Agents; Cell Line; Cell Survival; Chlorocebus aethiops; Coxsackievirus Infections; Enterovirus B, Human; Molecular Docking Simulation; Pyrimidines; Pyrroles; Rotavirus; Rotavirus Infections

2019
In silico insights into the identification of potential novel angiogenic inhibitors against human VEGFR-2: a new SAR-based hierarchical clustering approach.
    Journal of receptor and signal transduction research, 2018, Volume: 38, Issue:4

    Topics: Algorithms; Angiogenesis Inhibitors; Computer Simulation; Humans; Ligands; Molecular Docking Simulation; Neovascularization, Pathologic; Protein Binding; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; User-Computer Interface; Vascular Endothelial Growth Factor Receptor-2

2018
New Fused Pyrrolopyridine-Based Copolymers for Organic Solar Cell.
    Macromolecular rapid communications, 2019, Volume: 40, Issue:6

    Topics: Electric Power Supplies; Molecular Structure; Polymers; Pyrimidines; Pyrroles; Solar Energy

2019
Identification of the Binding Site of Apical Membrane Antigen 1 (AMA1) Inhibitors Using a Paramagnetic Probe.
    ChemMedChem, 2019, 03-05, Volume: 14, Issue:5

    Topics: Amino Acid Sequence; Antigens, Protozoan; Benzimidazoles; Binding Sites; Cell Membrane; Crystallography, X-Ray; Furans; Hydrophobic and Hydrophilic Interactions; Ligands; Magnetic Resonance Spectroscopy; Membrane Proteins; Models, Molecular; Molecular Probes; Molecular Structure; Peptides; Protein Binding; Protozoan Proteins; Pyrazoles; Pyrimidines; Pyrroles; Quinazolinones; Structure-Activity Relationship; Sulfonamides

2019
Pyrrolopyrimidine vs Imidazole-Phenyl-Thiazole Scaffolds in Nonpeptidic Dimerization Inhibitors of Leishmania infantum Trypanothione Reductase.
    ACS infectious diseases, 2019, 06-14, Volume: 5, Issue:6

    Topics: Imidazoles; Leishmania infantum; NADH, NADPH Oxidoreductases; Protein Interaction Domains and Motifs; Protein Multimerization; Protozoan Proteins; Pyrimidines; Pyrroles; Small Molecule Libraries; Thiazoles

2019
Extensive investigation of benzylic N-containing substituents on the pyrrolopyrimidine skeleton as Akt inhibitors with potent anticancer activity.
    Bioorganic chemistry, 2020, Volume: 97

    Topics: Antineoplastic Agents; Cell Cycle Checkpoints; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Lymphoma; Molecular Docking Simulation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrimidines; Pyrroles; Tumor Cells, Cultured

2020
Discovery of an Orally Active and Long-Acting DPP-IV Inhibitor through Property-Based Optimization with an in Silico Biotransformation Prediction Tool.
    ChemMedChem, 2020, 08-19, Volume: 15, Issue:16

    Topics: Administration, Oral; Biotransformation; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Dose-Response Relationship, Drug; Drug Discovery; Humans; Hypoglycemic Agents; Molecular Structure; Pyrimidines; Pyrroles; Structure-Activity Relationship

2020
Identification of a Biosynthetic Gene Cluster Responsible for the Production of a New Pyrrolopyrimidine Natural Product-Huimycin.
    Biomolecules, 2020, 07-18, Volume: 10, Issue:7

    Topics: Actinobacteria; Biological Products; Biosynthetic Pathways; Gene Expression; Genes, Bacterial; Multigene Family; Pyrimidines; Pyrroles; Streptomyces

2020
Novel pyrrolopyrimidine derivatives induce p53-independent apoptosis via the mitochondrial pathway in colon cancer cells.
    Chemico-biological interactions, 2020, Oct-01, Volume: 330

    Topics: Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Caspase 3; Caspase 9; Cell Line, Tumor; Colonic Neoplasms; Gene Knockout Techniques; HCT116 Cells; Humans; Mitochondria; Pyrimidines; Pyrroles; Tumor Suppressor Protein p53

2020
Targeting Her2-insYVMA with Covalent Inhibitors-A Focused Compound Screening and Structure-Based Design Approach.
    Journal of medicinal chemistry, 2020, 10-22, Volume: 63, Issue:20

    Topics: Dose-Response Relationship, Drug; Drug Design; Drug Evaluation, Preclinical; Humans; Kinetics; Models, Molecular; Molecular Structure; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Receptor, ErbB-2; Structure-Activity Relationship; Tumor Cells, Cultured

2020
Structure-activity relationship of 7-aryl-2-anilino-pyrrolopyrimidines as Mer and Axl tyrosine kinase inhibitors.
    Journal of enzyme inhibition and medicinal chemistry, 2020, Volume: 35, Issue:1

    Topics: Amino Acid Sequence; Aniline Compounds; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Phosphorylation; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Receptor Protein-Tyrosine Kinases; Signal Transduction; Structure-Activity Relationship

2020
Pyrrolopyrimidine Bumped Kinase Inhibitors for the Treatment of Cryptosporidiosis.
    ACS infectious diseases, 2021, 05-14, Volume: 7, Issue:5

    Topics: Animals; Antiprotozoal Agents; Cryptosporidiosis; Cryptosporidium; Mice; Protein Kinase Inhibitors; Pyrimidines; Pyrroles

2021
Design and synthesis of novel substituted benzyl pyrrolopyrimidine derivatives as selective BTK inhibitors for treating mantle cell lymphoma.
    Bioorganic chemistry, 2021, Volume: 112

    Topics: Agammaglobulinaemia Tyrosine Kinase; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Humans; Lymphoma, Mantle-Cell; Molecular Docking Simulation; Molecular Structure; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Reactive Oxygen Species; Structure-Activity Relationship

2021
N-Substituted pyrrolopyrimidines and purines as p90 ribosomal S6 protein kinase-2 (RSK2) inhibitors.
    Bioorganic & medicinal chemistry, 2021, 07-01, Volume: 41

    Topics: Catalytic Domain; Cell Line; Cell Survival; Enzyme Inhibitors; Humans; Models, Molecular; Protein Binding; Protein Conformation; Purines; Pyrimidines; Pyrroles; Ribosomal Protein S6 Kinases, 90-kDa

2021
Synthesis and structure-activity relationship studies of 1,5-isomers of triazole-pyrrolopyrimidine as selective Janus kinase 1 (JAK1) inhibitors.
    Bioorganic & medicinal chemistry letters, 2022, 01-01, Volume: 55

    Topics: Crystallography, X-Ray; Dose-Response Relationship, Drug; Humans; Janus Kinase 1; Janus Kinase Inhibitors; Models, Molecular; Molecular Structure; Pyrimidines; Pyrroles; Structure-Activity Relationship; Triazoles

2022
Discovery and Optimization of Pyrrolopyrimidine Derivatives as Selective Disruptors of the Perinucleolar Compartment, a Marker of Tumor Progression toward Metastasis.
    Journal of medicinal chemistry, 2022, 06-23, Volume: 65, Issue:12

    Topics: Biomarkers; Cell Nucleolus; Cell Nucleus; Humans; Neoplasms; Pyrimidines; Pyrroles

2022
Novel pyrrolopyrimidine derivatives: design, synthesis, molecular docking, molecular simulations and biological evaluations as antioxidant and anti-inflammatory agents.
    Journal of enzyme inhibition and medicinal chemistry, 2022, Volume: 37, Issue:1

    Topics: Anti-Inflammatory Agents; Antioxidants; COVID-19 Drug Treatment; Humans; Molecular Docking Simulation; Pandemics; Pyrimidines; Pyrroles; SARS-CoV-2

2022
Design, synthesis, and biological evaluation of pyrrolopyrimidine derivatives as novel Bruton's tyrosine kinase (BTK) inhibitors.
    European journal of medicinal chemistry, 2022, Nov-05, Volume: 241

    Topics: Agammaglobulinaemia Tyrosine Kinase; Humans; Molecular Docking Simulation; Molecular Structure; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Structure-Activity Relationship

2022
Activity of Tricyclic Pyrrolopyrimidine Gyrase B Inhibitor against Mycobacterium abscessus.
    Antimicrobial agents and chemotherapy, 2022, 09-20, Volume: 66, Issue:9

    Topics: Adenosine Triphosphatases; Animals; Anti-Bacterial Agents; DNA Gyrase; Mice; Microbial Sensitivity Tests; Mycobacterium abscessus; Mycobacterium Infections, Nontuberculous; Nontuberculous Mycobacteria; Pyrimidines; Pyrroles

2022
Identification of novel pyrrolopyrimidine and pyrrolopyridine derivatives as potent ENPP1 inhibitors.
    Journal of enzyme inhibition and medicinal chemistry, 2022, Volume: 37, Issue:1

    Topics: Animals; Mice; Phosphoric Diester Hydrolases; Pyrimidines; Pyrophosphatases; Pyrroles; Structure-Activity Relationship

2022
Design and Synthesis of Functionally Active 5-Amino-6-Aryl Pyrrolopyrimidine Inhibitors of Hematopoietic Progenitor Kinase 1.
    Journal of medicinal chemistry, 2023, 04-13, Volume: 66, Issue:7

    Topics: Humans; Protein Serine-Threonine Kinases; Pyrroles; Signal Transduction

2023
Design, synthesis and biological evaluation of pyrrolopyrimidine derivatives as novel and selective positive modulator of the small conductance Ca
    European journal of medicinal chemistry, 2023, Jun-05, Volume: 254

    Topics: Molecular Docking Simulation; Pyrimidines; Pyrroles; Small-Conductance Calcium-Activated Potassium Channels

2023