Compounds > pyrroles
Page last updated: 2024-08-18

pyrroles and pyrimidinones

pyrroles has been researched along with pyrimidinones in 149 studies

Research

Studies (149)

TimeframeStudies, this research(%)All Research%
pre-19905 (3.36)18.7374
1990's10 (6.71)18.2507
2000's70 (46.98)29.6817
2010's54 (36.24)24.3611
2020's10 (6.71)2.80

Authors

AuthorsStudies
Panzone, G; Schiatti, P; Selva, D; Tarzia, G1
Bahaji, EH; Couquelet, J; Harraga, S; Panouse-Perrin, J; Rubat, C; Tronche, P1
Bisagni, E; Legraverend, M; Ngongo-Tekam, RM; Zerial, A1
Brown, PR; Parks, RE1
Muzik, H; Paterson, AR; Warnick, CT1
Freeman, JJ; Kosh, JW; Powers, DL; Sowell, JW1
Garcia, GA; Hoops, GC; Townsend, LB2
Ficner, R; Reuter, K; Romier, C; Suck, D1
Hirota, K; Sajiki, H; Sako, M; Sawada, M1
Bagdassarian, CK; Furneaux, RH; Miles, RW; Schramm, VL; Tyler, PC1
Furneaux, RH; Girvin, ME; Grubmeyer, C; Kicska, G; Li, CM; Schramm, VL; Tyler, PC; Xu, Y1
Almo, SC; Furneaux, RH; Grubmeyer, C; Li, CM; Schramm, VL; Shi, W; Tyler, PC1
Almo, SC; Cahill, SM; Furneaux, RH; Girvin, ME; Grubmeyer, C; Li, CM; Schramm, VL; Shi, W; Tyler, PC1
Evans, GB; Furneaux, RH; Miles, RW; Parkin, DW; Schramm, VL; Tyler, PC1
Almo, SC; Furneaux, RH; Grubmeyer, C; Li, CM; Munagala, NR; Schramm, VL; Shi, W; Tyler, PC; Wang, CC1
Munagala, N; Sarver, AE; Wang, CC1
Angeletti, RH; Kicska, G; Miles, RW; Nieves, E; Schramm, VL; Wang, F1
Almo, SC; Fedorov, A; Fedorov, E; Furneaux, RH; Gainsford, GJ; Hanson, JC; Kicska, G; Larese, JZ; Schramm, VL; Shi, W; Tyler, PC1
Ficner, R; Garcia, GA; Gerber, HD; Goodenough-Lashua, DM; Grädler, U; Klebe, G; Reuter, K; Stubbs, MT1
Fairchild, C; Furneaux, RH; Hörig, H; Kaufman, HL; Kicska, GA; Long, L; Schramm, VL; Tyler, PC1
Ananth, SL; Bantia, S; Horn, LL; Hutchison, TL; Kilpatrick, JM; Miller, PJ; Montgomery, JA; Morris, PE; Parker, CD; Sandhu, JS1
Angeletti, RH; Grubmeyer, C; Nieves, E; Schramm, VL; Shi, W; Wang, F1
Basso, LA; Blanchard, JS; Furneaux, RH; Santos, DS; Schramm, VL; Shi, W; Tyler, PC1
Almo, SC; Basso, LA; Blanchard, JS; Furneaux, RH; Santos, DS; Schramm, VL; Shi, W; Tyler, PC1
Evans, GB; Furneaux, RH; Hutchison, TL; Kezar, HS; Morris, PE; Schramm, VL; Tyler, PC1
Evans, GB; Furneaux, RH; Kicska, GA; Kim, K; Schramm, VL; Tyler, PC1
Chen, C; Connors, PJ; Gao, Y; Gross, TD; Ling, N; Reinhart, GJ; Saunders, J; Struthers, RS; Wilcoxen, K; Zhu, YF1
Chen, C; Connors, PJ; Gao, Y; Gross, TD; Guo, Z; Reinhart, GJ; Saunders, J; Struthers, RS; Tucci, FC; Wilcoxen, K; Xie, Q; Zhu, YF1
Brower, JO; Lightner, DA1
Schramm, VL4
Ananth, SL; Babu, YS; Banti, S; Horn, LL; Miller, PJ; Parker, CD; Sandhu, JS1
Chen, C; Connors, PJ; Gross, TD; Guo, Z; Reinhart, GJ; Saunders, J; Struthers, RS; Tucci, FC; Wang, X; Zhu, YF1
Almo, SC; Cahill, SM; Evans, GB; Fedorov, A; Furneaux, RH; Kicska, GA; Lewandowicz, A; Schramm, VL; Shi, W; Tyler, PC1
Dineshkumar, TK; Subbulakshmi, C; Thanedar, S; Varshney, U1
Cervetto, L; Demontis, GC; Longoni, B; Macchia, B; Macchia, M; Minutolo, F; Orlandini, E; Ortore, G; Papi, C; Sbrana, A1
Babu, YS; Bennett, JC; Kilpatrick, JM; Moore, DR; Morris, PE; Phillips, D; Serota, DG1
Basso, LA; Cahill, SM; Evans, GB; Furneaux, RH; Girvin, ME; Grubmeyer, C; Lewandowicz, A; McDermott, A; Santos, DS; Sauve, AA; Schramm, VL; Tyler, PC; Zech, SG1
Almo, SC; Basso, LA; Evans, GB; Furneaux, RH; Lewandowicz, A; Santos, DS; Schramm, VL; Shi, W; Tyler, PC1
Bae, DS; Campain, JA; Handa, RJ; Yang, RS1
Ananth, SL; Bantia, S; Horn, LL; Parker, CD; Upshaw, R1
Gill, MJ; Mah Ming, JB1
Evans, GB; Furneaux, RH; Lewandowicz, A; Schramm, VL; Tyler, PC1
Basso, LA; Canduri, F; Dias, MV; Filgueira de Azevedo, W; Marangoni dos Santos, D; Mendes, MA; Palma, MS; Pereira, JH; Santos, DS; Silva, RG1
Evans, GB; Furneaux, RH; Schramm, VL; Tyler, PC1
Aronov, PA; Green, PG; Ngo, M; Patterson, TJ; Reznikova, TV; Rice, RH1
Almo, SC; Evans, GB; Furneaux, RH; Schramm, VL; Shi, W; Singh, V; Tyler, PC1
Cahill, SM; Callender, RH; Deng, H; Furneaux, RH; Girvin, ME; Lewandowicz, A; Schramm, VL; Tyler, PC1
Almo, SC; Evans, GB; Furneaux, RH; Kicska, GA; Kim, K; Lewandowicz, A; Schramm, VL; Shi, W; Ting, LM; Tyler, PC1
Evans, GB; Furneaux, RH; Schramm, VL; Singh, V; Tyler, PC1
Callender, R; Deng, H; Lewandowicz, A; Schramm, VL1
Gregus, Z; Németi, B1
Basso, LA; Canduri, F; de Azevedo, WF; Fadel, V; Palma, MS; Santos, DS1
Cornell, KA; Evans, GB; Furneaux, RH; Howell, PL; Lee, JE; Riscoe, MK; Schramm, VL; Singh, V; Tyler, PC1
Lewandowicz, A1
Evans, GB; Furneaux, RH; Kim, K; Lenz, DH; Lewandowicz, A; Mee, S; Painter, GF; Ringia, EA; Schramm, VL; Ting, LM; Tyler, PC; Zubkova, OV1
Basso, LA; Canduri, F; de Azevedo, WF; dos Santos, DM; Palma, MS; Santos, DS; Silva, RG1
Baize, MW; Demuth, TP; Ellis, CD; Fancher, AN; Laufersweiler, MC; Lu, W; O'Neil, SV; Oppong, KA; Soper, DL; Suchanek, MK; Wang, RL; Wang, Y; Wos, JA1
Gangjee, A; Kisliuk, RL; McGuire, JJ; Zeng, Y1
Ayres, M; Bantia, S; Davisson, J; Du, M; Faderl, S; Gandhi, V; Harman, L; Kantarjian, H; Kilpatrick, JM; Plunkett, W; Thomas, D; Wierda, WG1
Boiadjiev, SE; Lightner, DA; McDonagh, AF; Norona, WS; Woydziak, ZR1
Angeli, P; Cagnotto, A; Marucci, G; Materia, L; Mennini, T; Mereghetti, I; Modica, M; Pittalà, V; Romeo, G; Russo, F; Salerno, L; Siracusa, MA1
Gangjee, A; Jain, HD; Kisliuk, RL; Lin, X; McGuire, JJ; Phan, J; Song, X1
Brown, S; de Crécy-Lagard, V; Iwata-Reuyl, D; Lee, B; Reddy, RR; Schimmel, P; Swairjo, MA; Van Lanen, SG1
Hilmy, KM1
Barlow, J; Steyaert, J; Versées, W1
Balakrishnan, K; Gandhi, V; Keating, MJ; Nimmanapalli, R; Ravandi, F1
Alvarez, R; Botta, M; Corelli, F; Focher, F; Ghiron, C; Lossani, A; Manetti, F; Mugnaini, C; Semeraro, T; Valensin, S1
Gandhi, V; Ravandi, F1
Barrick, JE; Breaker, RR; Iwata-Reuyl, D; Jona, I; Kim, JN; Lee, BW; Lim, J; Regulski, EE; Ritwik, A; Roth, A; Welz, R; Winkler, WC1
Garcia, GA; Hurt, JK; Olgen, S1
Alfani, E; Altucci, L; Brosch, G; Di Noia, A; Galanello, R; Jelicic, K; Mai, A; Massa, S; Migliaccio, AR; Migliaccio, G; Nebbioso, A; Rotili, D; Valente, S1
Brown, T; Fox, KR; Gerrard, SR; Srinivasan, N1
Chang, CY; Chang, TY; Chao, YS; Coumar, MS; Hsieh, HP; Hsu, JT; Leou, JS; Lin, WH; Tan, UK; Wu, JS; Wu, SY1
Breaker, RR; Chervin, SM; Garcia, GA; Meyer, MM; Roth, A1
Delso, I; Merino, P; Tejero, T1
Cicmil, N; Huang, RH1
Fawcett, JP; Gu, J; Jiang, Y; Kong, J; Tang, Y; Teng, G; Wang, J; Wang, Y1
Feifel, R; Hawtin, S; Heng, R; Huppertz, C; Koch, G; Moebitz, H; Revesz, L; Scheufler, C; Schlapbach, A; Velcicky, J; Waelchli, R1
Bandarian, V; Krucinska, J; Spitale, RC; Torelli, AT; Wedekind, JE1
Kreutz, C; Lang, K; Micura, R; Polacek, N; Rieder, U1
Li, C; Liu, F1
Gangjee, A; Ihnat, MA; Kurup, S; Shenoy, SS; Thorpe, JE1
Kreutz, C; Micura, R; Rieder, U1
Guo, ZJ; Wu, N; Xu, Y1
Brooks, AF; Chen, YC; Garcia, GA; Goodenough-Lashua, DM; Kittendorf, JD; Showalter, HD1
Dračínský, M; Krečmerová, M; Mařák, D; Otmar, M; Votruba, I1
Cassera, MB; Hazleton, KZ; Schramm, VL; Zhang, Y1
Dewhurst, J; Petrone, PM; Pomerantz, AK; Tommasi, R; Whitehead, L1
Al-Hashimi, HM; Brooks, CL; Eichhorn, CD; Feng, J; Suddala, KC; Walter, NG1
Eriksson, H; Georgievska, B; Poewe, W; Stefanova, N; Wenning, GK1
Bayrakdarian, M; Buon, C; Cantin, LD; Grazzini, E; Hu, YJ; Labrecque, J; Leung, C; Luo, X; Martino, G; Paré, M; Payza, K; Popovic, N; Projean, D; Santhakumar, V; Tomaszewski, MJ; Walpole, C; Yu, XH1
Brooks, AF; Garcia, GA; Showalter, HD; Vélez-Martínez, CS1
Gerber, HD; Klebe, G1
Hanefeld, U; Hollmann, F; Moeller, K; Nguyen, GS1
Egger, S; Gruber, K; Klempier, N; Kratzer, R; Lyskowski, A; Nidetzky, B; Petschacher, B; Steinkellner, G; Wilding, B; Winkler, M1
Al-Hashimi, HM; Brooks, CL; Eichhorn, CD; Feng, J; Liberman, JA; Mustoe, AM; Rinaldi, AJ; Suddala, KC; Walter, NG; Wedekind, JE1
Deng, Z; Hong, K; Liu, Y; Ma, M; Wang, K; Xu, D; Zhou, T1
Bonte, D; Melcher, K; Sasi, NK; Soon, FF; Tiwari, K; Wang, T; Weinreich, M; Xu, HE1
Bogue, JT; Jenkins, JL; Liberman, JA; Salim, M; Wedekind, JE1
Bergman, L; Farde, L; Halldin, C; Johnström, P; Malmquist, J; Varnäs, K1
Clinch, K; Evans, GB; Freitas, EO; Guan, R; Meyer-Fernandes, JR; Nico, D; Palatnik-de-Sousa, CB; Schramm, VL; Tyler, PC1
Aytenfisu, A; Belashov, IA; Chan, D; Liberman, JA; Mathews, DH; Salim, M; Spitale, RC; Suddala, KC; Walter, NG; Wedekind, JE1
Dixon, N; Leigh, J; Lowe, PT; Micklefield, J; Robinson, CJ; Vincent, HA; Wu, MC1
Jia, L; Peng, S; Wang, L; Wu, C; Yang, J; Yang, X; Yin, J; Yuan, Z; Zhao, S1
Amini, N; Budd, S; Cselényi, Z; Farde, L; Halldin, C; Helin, S; Johnström, P; Jucaite, A; Kirjavainen, A; Kugler, AR; Minkwitz, M; Posener, JA; Rinne, JO; Svenningsson, P; Varnäs, K; Varrone, A1
Georgievska, B; Kaindlstorfer, C; Kugler, AR; Mather, RJ; Poewe, W; Sommer, P; Stefanova, N; Wenning, GK1
Akiyama, R; Anderson, JL; Denny, CT; Federman, N; Park, A; Tap, WD1
Bridgeman, VL; Foo, S; Frentzas, S; Gore, M; Larkin, J; Nathan, MR; Nathan, PD; Powles, T; Preece, N; Reynolds, AR; Springer, CJ; Vasudev, NS; Vermeulen, PB; Wan, E; Welti, JC1
Gu, J; Peng, W; Sun, H; Sun, L; Sun, Y; Wang, J; Yang, Y1
Alvarez, J; Bon Ramos, A; Iwata-Reuyl, D; Mei, X; Samanta, U; Swairjo, MA1
Altman, MD; Chen, D; Childers, KK; Davies, IW; Haidle, A; Harsch, A; Hayashi, M; Hou, Y; Hutton, M; Jewell, JP; Katz, JD; Munoz, B; Munshi, S; Northrup, A; Nuthall, H; Stanton, MG; Su, HP; Szewczak, A; Warren, L; Zabierek, AA1
Cil, O; Donowitz, M; Gillespie, AM; Lee, S; Lin, R; Phuan, PW; Tradtrantip, L; Tse, M; Verkman, AS; Yin, J; Zachos, NC1
Altman, MD; Chen, D; Childers, KK; Davies, IW; Haidle, AM; Harsch, A; Hayashi, M; Hou, Y; Hutton, M; Jewell, JP; Katz, JD; Munoz, B; Northrup, A; Nuthall, H; Stanton, MG; Szewczak, A; Warren, L; Zabierek, AA1
Seeliger, JC; Topp, S; Van Vlack, ER1
Chevot, F; Connon, SJ; Cotter, M; Cunningham, C; Fergus, C; Kelly, VP; Mills, KH; Southern, JM; Varghese, S1
Ayele, T; Choi, YJ; Deventer, KV; Gibala, KS; Resendiz, MJE1
Gaboriau, D; Quachthithu, H; Rainey, MD; Santocanale, C1
Berg, A; Dinavahi, SS; Drabick, JJ; Gowda, R; Neves, RI; Noory, MA; Robertson, GP1
Famulok, M; Kerzhner, M; Matsuoka, H; Schiemann, O; Wuebben, C1
Al-Huniti, N; Li, J; Li, Y; Mullen, JA; Savage, A; Taylor, W; Tong, X; Xu, H; Zhou, D1
Andrade, CH; Bianco Júnior, C; Carvalho, LJM; Castro, RN; Daniel-Ribeiro, CT; Domingues, LHP; Graebin, CS; Moreira Filho, JT; Neves, BJ; Rogerio, KR1
Andrs, M; Gorecki, L; Havelek, R; Jun, D; Korabecny, J; Polednikova, M; Pospisilova, M; Rezacova, M; Seifrtova, M; Tichy, A; Vejrychova, K1
Coquel, F; Lin, YL; MacKeigan, JP; Pasero, P; Sasi, NK; Weinreich, M1
Belashov, IA; Ermolenko, DN; Ling, C; Salim, M; Warnasooriya, C; Wedekind, JE1
Frener, M; Lusser, A; Micura, R; Neuner, E1
Sinumvayo, JP; Tuyishime, P; Zhao, C1
Cil, O; Duan, T; Thiagarajah, JR; Verkman, AS1
Baldini, E; Bernardini, G; Jacomelli, G; Micheli, V; Mugnaini, C; Santucci, A1
Barchi, JJ; Boer, RE; Connelly, CM; Ferré-D'Amaré, AR; Moon, MH; Numata, T; Schneekloth, JS; Sinniah, RS1
Brennan, PE; Chen, C; Cheng, W; Ding, B; Huang, L; Li, H; Li, L; Niu, L; Seupel, R; Wu, C; Yang, S1
Cil, O; Donowitz, M; Duan, T; Lin, R; Sarker, R; Tse, CM; Verkman, AS1
Hou, XJ; Wang, YF; Wu, CF; Yang, JY; Zhang, Z; Zhu, L1
Beaufils, F; Bohnacker, T; Borsari, C; Dall'Asen, A; Fabbro, D; Hebeisen, P; Hillmann, P; Jackson, E; Langlois, JB; Melone, A; Rageot, D; Sele, AM; Wymann, MP1
Tytgat, GNJ1
Bandyopadhyay, T; Ganguly, B; Ghosh, S; Jana, K; Wakchaure, PD1
Dutta, D; Wedekind, JE1
Balamkundu, S; Carstens, AB; Cui, L; de Crécy-Lagard, V; Dedon, PC; Fa Lui, C; Gnanakalai, S; Hansen, LH; Hatfull, GF; Hillebrand, R; Hutinet, G; Jacobs-Sera, D; Kot, W; Lee, YJ; Moineau, S; Neelakandan, R; Sassanfar, M; Tremblay, D; Weigele, P1
Chatterjee, S; Daher, M; Lund, PE; Walter, NG1
Kierzek, E; Kierzek, R1
Adderley, T; Christopher, G; Irwin, MS; Kano, Y; Kee, L; Ladumor, Y; Ohh, M; Robinson, CM; Valencia-Sama, I1
Carstens, AB; Cui, L; de Crécy-Lagard, V; Dedon, PC; Hansen, LH; Hutinet, G; Kot, W; Moineau, S; Nielsen, TK; Olsen, NS; Swairjo, MA1
Belinsky, MG; D'Souza, J; DeMatteo, R; Devarajan, K; Duncan, JS; Einarson, MB; Heinrich, MC; Johnson, KJ; Klug, L; Kozinova, M; Litwin, S; Rink, L; Sharipova, D; von Mehren, M; Ye, S; Zhou, Y1
Demizu, Y; Imamura, Y; Kittaka, A; Kohara, M; Kurihara, M; Kuwata, K; Moriya, SS; Shibasaki, H; Sugiyama, T1
Blau, ME; Cavender, CE; Jenkins, JL; Mathews, DH; Schroeder, GM; Wedekind, JE1
Fischer, TR; Grimm, M; Helm, M; Kallert, E; Kersten, C; Schneider, S1

Reviews

8 review(s) available for pyrroles and pyrimidinones

ArticleYear
Development of transition state analogues of purine nucleoside phosphorylase as anti-T-cell agents.
    Biochimica et biophysica acta, 2002, Jul-18, Volume: 1587, Issue:2-3

    Topics: Animals; Antineoplastic Agents; Drug Design; Enzyme Inhibitors; Humans; Leukemia, T-Cell; Mice; Nucleosides; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; Static Electricity; T-Lymphocytes; Transplantation, Heterologous

2002
Immucillins as antibiotics for T-cell proliferation and malaria.
    Nucleosides, nucleotides & nucleic acids, 2004, Volume: 23, Issue:8-9

    Topics: Animals; Anti-Bacterial Agents; Cell Proliferation; Deoxyguanosine; Erythrocytes; Humans; Hypoxanthine; Kinetics; Lymphocyte Activation; Malaria; Models, Chemical; Phenotype; Plasmodium falciparum; Purine Nucleosides; Purines; Pyrimidinones; Pyrroles; T-Lymphocytes

2004
Enzymatic transition states: thermodynamics, dynamics and analogue design.
    Archives of biochemistry and biophysics, 2005, Jan-01, Volume: 433, Issue:1

    Topics: Animals; Catalysis; Crystallography, X-Ray; Deuterium; Drug Design; Enzyme Inhibitors; Enzymes; Humans; Hydrogen; Hydrogen Bonding; Inosine; Kinetics; Models, Molecular; Motion; Protein Conformation; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; Static Electricity; Substrate Specificity; Thermodynamics

2005
[Tight binding transition state analogues of purine nucleoside phosphorylase--meaning, design and properties].
    Postepy biochemii, 2004, Volume: 50, Issue:3

    Topics: Animals; Enzyme Inhibitors; Humans; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; Structure-Activity Relationship

2004
Novel purine nucleoside analogues for T-cell-lineage acute lymphoblastic leukaemia and lymphoma.
    Expert opinion on investigational drugs, 2006, Volume: 15, Issue:12

    Topics: Adult; Animals; Antimetabolites, Antineoplastic; Arabinonucleosides; Child; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Deoxyguanosine; Drug Design; Drug Screening Assays, Antitumor; Drugs, Investigational; Humans; Leukemia-Lymphoma, Adult T-Cell; Leukemia, Experimental; Lymphoma, T-Cell; Mice; Neoplasm Proteins; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; T-Lymphocytes

2006
Current developments in the synthesis and biological activity of aza-C-nucleosides: immucillins and related compounds.
    Current medicinal chemistry, 2008, Volume: 15, Issue:10

    Topics: Adenine; Adenosine; Aza Compounds; Glycoside Hydrolases; N-Glycosyl Hydrolases; Nucleosides; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; Pyrrolidines

2008
Purine and pyrimidine pathways as targets in Plasmodium falciparum.
    Current topics in medicinal chemistry, 2011, Volume: 11, Issue:16

    Topics: Antimalarials; Binding Sites; Drug Design; Enzyme Inhibitors; Humans; Malaria, Falciparum; Models, Molecular; Plasmodium falciparum; Protein Binding; Protozoan Proteins; Purine Nucleosides; Purines; Pyrimidines; Pyrimidinones; Pyrroles; Substrate Specificity

2011
Recent advances and future trends of riboswitches: attractive regulatory tools.
    World journal of microbiology & biotechnology, 2018, Nov-09, Volume: 34, Issue:11

    Topics: Aptamers, Nucleotide; Aptamers, Peptide; Bacteria; Bacterial Proteins; Gene Expression Regulation, Bacterial; Genes, Bacterial; Glycine; Ligands; Pyrimidinones; Pyrroles; Riboswitch; RNA, Bacterial

2018

Trials

2 trial(s) available for pyrroles and pyrimidinones

ArticleYear
A proof-of-principle pharmacokinetic, pharmacodynamic, and clinical study with purine nucleoside phosphorylase inhibitor immucillin-H (BCX-1777, forodesine).
    Blood, 2005, Dec-15, Volume: 106, Issue:13

    Topics: Adult; Aged; Deoxyguanine Nucleotides; Enzyme Inhibitors; Female; Humans; Leukemia, Lymphoid; Male; Middle Aged; Molecular Structure; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; Treatment Outcome

2005
Effect of the myeloperoxidase inhibitor AZD3241 on microglia: a PET study in Parkinson's disease.
    Brain : a journal of neurology, 2015, Volume: 138, Issue:Pt 9

    Topics: Aged; Dose-Response Relationship, Drug; Double-Blind Method; Enzyme Inhibitors; Female; Fluorine Radioisotopes; Follow-Up Studies; Humans; Male; Microglia; Middle Aged; Parkinson Disease; Polymorphism, Single Nucleotide; Positron-Emission Tomography; Protein Binding; Pyrimidines; Pyrimidinones; Pyrroles; Receptors, GABA; Severity of Illness Index

2015

Other Studies

139 other study(ies) available for pyrroles and pyrimidinones

ArticleYear
Synthesis and anti-inflammatory properties of some pyrrolo(1H,3H)[3,4-d]pyrimidin-2-ones and pyrrolo(1H,6H)[3,4-d]pyrimidin-2-ones.
    Il Farmaco; edizione scientifica, 1979, Volume: 34, Issue:4

    Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Aspirin; Edema; Female; Indomethacin; Male; Mice; Pyrimidinones; Pyrroles; Rats

1979
Studies on immunostimulating derivatives: synthesis of some pyrrolo[1,2-c]pyrimidines.
    Chemical & pharmaceutical bulletin, 1991, Volume: 39, Issue:8

    Topics: Adjuvants, Immunologic; Animals; Humans; Hypnotics and Sedatives; In Vitro Techniques; Mice; Motor Activity; Pyrimidines; Pyrimidinones; Pyrroles; T-Lymphocytes

1991
(+/-)-2-Amino-3,4-dihydro-7-[2,3-dihydroxy-4-(hydroxymethyl)-1- cyclopentyl]-7H-pyrrolo[2,3-d]pyrimidin-4-ones: new carbocyclic analogues of 7-deazaguanosine with antiviral activity.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:10

    Topics: Animals; Antiviral Agents; Chemical Phenomena; Chemistry; DNA Viruses; Herpes Simplex; Mice; Pyrimidinones; Pyrroles; RNA Viruses; Simplexvirus; Structure-Activity Relationship; Virus Replication

1985
Incorporation of nucleosides into the nucleotide pools of human erythrocytes. Adenosine and its analogs.
    Biochemistry, 1973, Aug-14, Volume: 12, Issue:17

    Topics: Adenine Nucleotides; Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Aminohydrolases; Antibiotics, Antineoplastic; Aza Compounds; Carbohydrate Metabolism; Deoxyadenosines; Erythrocytes; Fluorine; Humans; Inosine; Mercaptopurine; Nucleosides; Phosphotransferases; Pyrazoles; Pyrimidines; Pyrimidinones; Pyrroles; Ribonucleosides; Structure-Activity Relationship

1973
Interference with nucleoside transport in mouse lymphoma cells proliferating in culture.
    Cancer research, 1972, Volume: 32, Issue:10

    Topics: Adenosine; Animals; Ascitic Fluid; Aza Compounds; Biological Transport; Bromodeoxyuridine; Carbon Isotopes; Cell Division; Cell-Free System; Cells, Cultured; Guanosine; Inosine; Lymphoma; Male; Mercaptopurine; Methotrexate; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Pyrazoles; Pyrimidinones; Pyrroles; Ribonucleosides; Thymidine; Time Factors; Transplantation, Homologous

1972
Anticonvulsant properties of selected pyrrolo[2,3-d]pyrimidine-2,4-diones and intermediates.
    Journal of pharmaceutical sciences, 1980, Volume: 69, Issue:4

    Topics: Animals; Anticonvulsants; Electroshock; Male; Mice; Pentylenetetrazole; Phenytoin; Pyrimidinones; Pyrroles; Seizures; Solubility; Structure-Activity Relationship; Trimethadione

1980
Mechanism-based inactivation of tRNA-guanine transglycosylase from Escherichia coli by 2-amino-5-(fluoromethyl)pyrrolo[2,3-d]pyrimidin-4 (3H)-one.
    Biochemistry, 1995, Nov-28, Volume: 34, Issue:47

    Topics: Enzyme Inhibitors; Escherichia coli; Pentosyltransferases; Pyrimidinones; Pyrroles; RNA, Transfer

1995
tRNA-guanine transglycosylase from Escherichia coli: structure-activity studies investigating the role of the aminomethyl substituent of the heterocyclic substrate PreQ1.
    Biochemistry, 1995, Nov-21, Volume: 34, Issue:46

    Topics: Binding, Competitive; Enzyme Inhibitors; Escherichia coli; Guanine; Kinetics; Molecular Structure; Pentosyltransferases; Purines; Pyrimidinones; Pyrroles; RNA, Transfer; Structure-Activity Relationship; Substrate Specificity

1995
Crystal structure of tRNA-guanine transglycosylase: RNA modification by base exchange.
    The EMBO journal, 1996, Jun-03, Volume: 15, Issue:11

    Topics: Amino Acid Sequence; Anticodon; Catalysis; Crystallography, X-Ray; Guanine; Metalloproteins; Models, Molecular; Molecular Sequence Data; Nucleic Acid Precursors; Pentosyltransferases; Pyrimidinones; Pyrroles; Recombinant Proteins; RNA, Transfer; Sequence Alignment; Sequence Homology, Amino Acid; Structure-Activity Relationship; Zinc; Zymomonas

1996
Synthesis of 6-aminouracils and pyrrolo[2,3-d]pyrimidine-2,4-diones and their inhibitory effect on thymidine phosphorylase.
    Nucleic acids symposium series, 1997, Issue:37

    Topics: Antimetabolites, Antineoplastic; Cell Division; Drug Design; Enzyme Inhibitors; Female; Humans; Neovascularization, Pathologic; Pregnancy; Pyrimidinones; Pyrroles; Thymidine Phosphorylase; Tumor Cells, Cultured; Uracil

1997
One-third-the-sites transition-state inhibitors for purine nucleoside phosphorylase.
    Biochemistry, 1998, Jun-16, Volume: 37, Issue:24

    Topics: Animals; Cattle; Enzyme Inhibitors; Humans; Kinetics; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; Structure-Activity Relationship; Substrate Specificity; T-Lymphocytes

1998
Transition-state analogs as inhibitors of human and malarial hypoxanthine-guanine phosphoribosyltransferases.
    Nature structural biology, 1999, Volume: 6, Issue:6

    Topics: Animals; Binding Sites; Catalysis; Diphosphates; Drug Design; Enzyme Inhibitors; Guanosine Monophosphate; Humans; Hydrogen Bonding; Hypoxanthine; Hypoxanthine Phosphoribosyltransferase; Inosine Monophosphate; Kinetics; Magnesium Compounds; Nuclear Magnetic Resonance, Biomolecular; Phosphoribosyl Pyrophosphate; Phosphorylation; Plasmodium falciparum; Protein Binding; Protons; Purine Nucleosides; Pyrimidinones; Pyrroles

1999
The 2.0 A structure of human hypoxanthine-guanine phosphoribosyltransferase in complex with a transition-state analog inhibitor.
    Nature structural biology, 1999, Volume: 6, Issue:6

    Topics: Binding Sites; Catalytic Domain; Crystallization; Crystallography, X-Ray; Diphosphates; Electrons; Enzyme Inhibitors; Humans; Hydrogen Bonding; Hypoxanthine Phosphoribosyltransferase; Ions; Magnesium; Magnesium Compounds; Models, Molecular; Molecular Sequence Data; Nitrogen; Oxygen; Phosphates; Protein Binding; Protein Structure, Secondary; Pyrimidinones; Pyrroles; Solvents

1999
The 2.0 A structure of malarial purine phosphoribosyltransferase in complex with a transition-state analogue inhibitor.
    Biochemistry, 1999, Aug-03, Volume: 38, Issue:31

    Topics: Animals; Catalytic Domain; Crystallography, X-Ray; Enzyme Inhibitors; Humans; Macromolecular Substances; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Pentosyltransferases; Plasmodium falciparum; Protein Conformation; Protein Folding; Protein Structure, Secondary; Protons; Purine Nucleosides; Pyrimidinones; Pyrroles

1999
Iminoribitol transition state analogue inhibitors of protozoan nucleoside hydrolases.
    Biochemistry, 1999, Oct-05, Volume: 38, Issue:40

    Topics: Animals; Crithidia fasciculata; Enzyme Inhibitors; Guanosine; Hydrogen Bonding; Inosine; Macromolecular Substances; N-Glycosyl Hydrolases; Protozoan Proteins; Purines; Pyrimidinones; Pyrroles; Ribitol; Ribose; Structure-Activity Relationship; Substrate Specificity

1999
Crystal structures of Giardia lamblia guanine phosphoribosyltransferase at 1.75 A(,).
    Biochemistry, 2000, Jun-13, Volume: 39, Issue:23

    Topics: Animals; Binding Sites; Crystallography, X-Ray; Dimerization; Enzyme Inhibitors; Giardia lamblia; Hypoxanthine Phosphoribosyltransferase; Models, Molecular; Molecular Conformation; Pyrimidinones; Pyrroles; Recombinant Proteins

2000
Converting the guanine phosphoribosyltransferase from Giardia lamblia to a hypoxanthine-guanine phosphoribosyltransferase.
    The Journal of biological chemistry, 2000, Nov-24, Volume: 275, Issue:47

    Topics: Amino Acid Sequence; Animals; Binding Sites; Crystallography, X-Ray; Giardia lamblia; Giardiasis; Humans; Hypoxanthine Phosphoribosyltransferase; Kinetics; Magnesium; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphates; Protein Conformation; Pyrimidinones; Pyrroles; Structure-Activity Relationship

2000
Immucillin-H binding to purine nucleoside phosphorylase reduces dynamic solvent exchange.
    Protein science : a publication of the Protein Society, 2000, Volume: 9, Issue:9

    Topics: Amino Acid Sequence; Mass Spectrometry; Models, Molecular; Molecular Sequence Data; Protein Binding; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; Solvents

2000
Transition state structure of purine nucleoside phosphorylase and principles of atomic motion in enzymatic catalysis.
    Biochemistry, 2001, Jan-30, Volume: 40, Issue:4

    Topics: Animals; Binding Sites; Catalysis; Cattle; Crystallography, X-Ray; Deuterium; Electron Transport; Enzyme Inhibitors; Hydrolysis; Inosine; Macromolecular Substances; Motion; Phosphates; Protein Conformation; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles

2001
A new target for shigellosis: rational design and crystallographic studies of inhibitors of tRNA-guanine transglycosylase.
    Journal of molecular biology, 2001, Feb-23, Volume: 306, Issue:3

    Topics: Binding Sites; Computer Simulation; Crystallography, X-Ray; Databases as Topic; Drug Design; Dysentery, Bacillary; Enzyme Inhibitors; Guanine; Kinetics; Models, Molecular; Molecular Structure; Pentosyltransferases; Phthalazines; Pyrimidinones; Pyrroles; Shigella flexneri; Software; Static Electricity; Thermodynamics; Zymomonas

2001
Immucillin H, a powerful transition-state analog inhibitor of purine nucleoside phosphorylase, selectively inhibits human T lymphocytes.
    Proceedings of the National Academy of Sciences of the United States of America, 2001, Apr-10, Volume: 98, Issue:8

    Topics: Apoptosis; Cell Division; Deoxyguanine Nucleotides; Enzyme Inhibitors; Humans; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; T-Lymphocytes; Tumor Cells, Cultured

2001
Purine nucleoside phosphorylase inhibitor BCX-1777 (Immucillin-H)--a novel potent and orally active immunosuppressive agent.
    International immunopharmacology, 2001, Volume: 1, Issue:6

    Topics: Administration, Oral; Animals; Biological Availability; Enzyme Inhibitors; Graft vs Host Reaction; Guanosine Triphosphate; Immunosuppressive Agents; Indicators and Reagents; Injections, Intravenous; Lymphocyte Culture Test, Mixed; Mice; Mice, Inbred BALB C; Mice, SCID; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; Survival Analysis; T-Lymphocytes

2001
A transition-state analogue reduces protein dynamics in hypoxanthine-guanine phosphoribosyltransferase.
    Biochemistry, 2001, Jul-10, Volume: 40, Issue:27

    Topics: Amino Acid Sequence; Binding Sites; Catalytic Domain; Chromatography, High Pressure Liquid; Deuterium; Diphosphates; Enzyme Inhibitors; Humans; Hypoxanthine Phosphoribosyltransferase; Isoleucine; Leucine; Macromolecular Substances; Magnesium; Magnesium Compounds; Mass Spectrometry; Molecular Sequence Data; Pepsin A; Peptide Fragments; Phenylalanine; Protons; Pyrimidinones; Pyrroles

2001
Purine nucleoside phosphorylase from Mycobacterium tuberculosis. Analysis of inhibition by a transition-state analogue and dissection by parts.
    Biochemistry, 2001, Jul-27, Volume: 40, Issue:28

    Topics: Binding, Competitive; Catalysis; Cloning, Molecular; Enzyme Inhibitors; Gene Expression Regulation, Bacterial; Hydrogen-Ion Concentration; Kinetics; Molecular Weight; Mycobacterium tuberculosis; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; Recombinant Proteins

2001
Structures of purine nucleoside phosphorylase from Mycobacterium tuberculosis in complexes with immucillin-H and its pieces.
    Biochemistry, 2001, Jul-27, Volume: 40, Issue:28

    Topics: Actinomycetales; Animals; Binding Sites; Catalysis; Cattle; Enzyme Inhibitors; Enzyme Stability; Escherichia coli; Macromolecular Substances; Models, Molecular; Mycobacterium tuberculosis; Phosphates; Protein Conformation; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles

2001
Addition of lithiated 9-deazapurine derivatives to a carbohydrate cyclic imine: convergent synthesis of the aza-C-nucleoside immucillins.
    The Journal of organic chemistry, 2001, Aug-24, Volume: 66, Issue:17

    Topics: Imines; Lithium; Purines; Pyrimidine Nucleosides; Pyrimidinones; Pyrroles

2001
Purine-less death in Plasmodium falciparum induced by immucillin-H, a transition state analogue of purine nucleoside phosphorylase.
    The Journal of biological chemistry, 2002, Feb-01, Volume: 277, Issue:5

    Topics: Animals; Biological Transport; Cell Death; Enzyme Inhibitors; Erythrocytes; Humans; Hypoxanthine; Kinetics; Models, Biological; Plasmodium falciparum; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Purines; Pyrimidinones; Pyrroles; Time Factors

2002
Initial structure-activity relationship studies of a novel series of pyrrolo[1,2-a]pyrimid-7-ones as GnRH receptor antagonists.
    Bioorganic & medicinal chemistry letters, 2002, Feb-11, Volume: 12, Issue:3

    Topics: Animals; Humans; Indicators and Reagents; Kinetics; Pyrimidinones; Pyrroles; Radioligand Assay; Rats; Receptors, LHRH; Structure-Activity Relationship

2002
A novel synthesis of 2-arylpyrrolo[1,2-a]pyrimid-7-ones and their structure-activity relationships as potent GnRH receptor antagonists.
    Bioorganic & medicinal chemistry letters, 2002, Feb-11, Volume: 12, Issue:3

    Topics: Animals; Humans; Indicators and Reagents; Kinetics; Pyrimidinones; Pyrroles; Radioligand Assay; Rats; Receptors, LHRH; Structure-Activity Relationship

2002
Synthesis and spectroscopic properties of a new class of strongly fluorescent dipyrrinones.
    The Journal of organic chemistry, 2002, Apr-19, Volume: 67, Issue:8

    Topics: Bilirubin; Chemistry, Organic; Crystallography, X-Ray; Fluorescent Dyes; Heterocyclic Compounds, 3-Ring; Magnetic Resonance Spectroscopy; Molecular Conformation; Molecular Structure; Pyrimidinones; Pyrroles; Spectrophotometry, Ultraviolet; Structure-Activity Relationship

2002
Comparison of in vivo efficacy of BCX-1777 and cyclosporin in xenogeneic graft-vs.-host disease: the role of dGTP in antiproliferative action of BCX-1777.
    International immunopharmacology, 2002, Volume: 2, Issue:7

    Topics: Animals; Cyclosporine; Deoxyguanine Nucleotides; Dogs; Drug Therapy, Combination; Graft vs Host Disease; Growth Inhibitors; Humans; Immunosuppressive Agents; Lymphocytes; Macaca fascicularis; Mice; Mice, Inbred BALB C; Mice, SCID; Purine Nucleosides; Pyrimidinones; Pyrroles; Rats; Rats, Sprague-Dawley; Survival Rate; Transplantation, Heterologous

2002
A novel synthesis of 7-aryl-8-fluoro-pyrrolo[1,2-a]pyrimid-4-ones as potent, stable GnRH receptor antagonists.
    Bioorganic & medicinal chemistry letters, 2002, Dec-02, Volume: 12, Issue:23

    Topics: Calcium; Cell Line; Cyclization; Drug Stability; Humans; Models, Molecular; Protein Binding; Pyrimidinones; Pyrroles; Receptors, LHRH; Recombinant Proteins; Structure-Activity Relationship; Thermodynamics

2002
Atomic dissection of the hydrogen bond network for transition-state analogue binding to purine nucleoside phosphorylase.
    Biochemistry, 2002, Dec-10, Volume: 41, Issue:49

    Topics: Animals; Asparagine; Binding Sites; Catalysis; Cattle; Crystallography, X-Ray; Enzyme Inhibitors; Glutamic Acid; Hydrogen Bonding; Hydrogen-Ion Concentration; Hypoxanthine; Imines; Nuclear Magnetic Resonance, Biomolecular; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; Ribonucleosides; Static Electricity; Substrate Specificity; Thermodynamics

2002
An unexpected absence of queuosine modification in the tRNAs of an Escherichia coli B strain.
    Microbiology (Reading, England), 2002, Volume: 148, Issue:Pt 12

    Topics: Electrophoresis, Polyacrylamide Gel; Escherichia coli; Nucleoside Q; Pentosyltransferases; Pyrimidinones; Pyrroles; RNA, Bacterial; RNA, Transfer, Tyr; Urea

2002
New N-n-propyl-substituted 3-aryl- and 3-cyclohexylpiperidines as partial agonists at the D4 dopamine receptor.
    Journal of medicinal chemistry, 2003, Jan-02, Volume: 46, Issue:1

    Topics: Animals; Binding, Competitive; Corpus Striatum; Crystallography, X-Ray; Dopamine Agonists; Guanine Nucleotides; Guinea Pigs; In Vitro Techniques; Male; Melatonin; Piperidines; Purine Nucleosides; Pyrimidinones; Pyrroles; Radioligand Assay; Receptors, Dopamine D2; Receptors, Dopamine D4; Retina; Structure-Activity Relationship

2003
Intravenous and oral pharmacokinetic study of BCX-1777, a novel purine nucleoside phosphorylase transition-state inhibitor. In vivo effects on blood 2'-deoxyguanosine in primates.
    International immunopharmacology, 2003, Volume: 3, Issue:4

    Topics: Administration, Oral; Animals; Area Under Curve; Biological Availability; Deoxyguanosine; Enzyme Inhibitors; Erythrocytes; Injections, Intravenous; Inosine; Macaca fascicularis; Male; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles

2003
Ionic states of substrates and transition state analogues at the catalytic sites of N-ribosyltransferases.
    Biochemistry, 2003, May-20, Volume: 42, Issue:19

    Topics: Catalytic Domain; Guanosine; Guanosine Monophosphate; Humans; Hydrogen-Ion Concentration; Hypoxanthine Phosphoribosyltransferase; In Vitro Techniques; Ions; Kinetics; Molecular Structure; Mycobacterium tuberculosis; Nuclear Magnetic Resonance, Biomolecular; Phosphorylation; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; Recombinant Proteins; Substrate Specificity

2003
Over-the-barrier transition state analogues and crystal structure with Mycobacterium tuberculosis purine nucleoside phosphorylase.
    Biochemistry, 2003, May-27, Volume: 42, Issue:20

    Topics: Catalytic Domain; Crystallography, X-Ray; Inosine; Kinetics; Models, Molecular; Molecular Mimicry; Mycobacterium tuberculosis; Protein Conformation; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; Static Electricity; Substrate Specificity

2003
Gene expression patterns as potential molecular biomarkers for malignant transformation in human keratinocytes treated with MNNG, arsenic, or a metal mixture.
    Toxicological sciences : an official journal of the Society of Toxicology, 2003, Volume: 74, Issue:1

    Topics: Animals; Arsenates; Bile; Biotransformation; Chromatography, High Pressure Liquid; Dithiothreitol; Enzyme Inhibitors; Erythrocytes; Humans; In Vitro Techniques; Inosine; Male; Oxidation-Reduction; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; Rats; Rats, Wistar; Spectrophotometry, Atomic; Sulfhydryl Reagents

2003
Mechanism of inhibition of T-acute lymphoblastic leukemia cells by PNP inhibitor--BCX-1777.
    International immunopharmacology, 2003, Volume: 3, Issue:6

    Topics: Apoptosis; Cell Division; Cell Line; Culture Media; Half-Life; HIV Reverse Transcriptase; Humans; Lamivudine; Leukemia-Lymphoma, Adult T-Cell; Lymphocytes; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; Reverse Transcriptase Inhibitors; Stavudine

2003
Drug-induced rhabdomyolysis after concomitant use of clarithromycin, atorvastatin, and lopinavir/ritonavir in a patient with HIV.
    AIDS patient care and STDs, 2003, Volume: 17, Issue:5

    Topics: Adult; Anti-Bacterial Agents; Atorvastatin; Clarithromycin; Drug Interactions; Drug Therapy, Combination; Heptanoic Acids; HIV Infections; HIV Protease Inhibitors; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lopinavir; Male; Pyrimidinones; Pyrroles; Rhabdomyolysis; Ritonavir

2003
Exploring structure-activity relationships of transition state analogues of human purine nucleoside phosphorylase.
    Journal of medicinal chemistry, 2003, Jul-17, Volume: 46, Issue:15

    Topics: Animals; Cattle; Enzyme Inhibitors; Humans; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; Structure-Activity Relationship

2003
Structural basis for inhibition of human PNP by immucillin-H.
    Biochemical and biophysical research communications, 2003, Oct-03, Volume: 309, Issue:4

    Topics: Crystallography, X-Ray; Enzyme Inhibitors; Humans; Ligands; Models, Molecular; Protein Conformation; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles

2003
Synthesis of a transition state analogue inhibitor of purine nucleoside phosphorylase via the Mannich reaction.
    Organic letters, 2003, Oct-02, Volume: 5, Issue:20

    Topics: Amines; Enzyme Inhibitors; Humans; Purine-Nucleoside Phosphorylase; Purines; Pyrimidinones; Pyrroles

2003
Transition state analogues for enzymes of nucleic acid metabolism.
    Nucleic acids research. Supplement (2001), 2003, Issue:3

    Topics: Animals; Cattle; Enzyme Inhibitors; Enzymes; Humans; Kinetics; Nucleic Acids; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; Ricin

2003
Biological activity of inorganic arsenic and antimony reflects oxidation state in cultured human keratinocytes.
    Chemical research in toxicology, 2003, Volume: 16, Issue:12

    Topics: Animals; Antimony; Arsenic; Biotransformation; Cattle; Cell Line; Dose-Response Relationship, Drug; Enzyme Induction; Enzyme Inhibitors; Fibroblasts; Guanine; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Keratinocytes; Membrane Proteins; Oxidation-Reduction; Protein Precursors; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; Spleen

2003
Picomolar transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase and X-ray structure with MT-immucillin-A.
    Biochemistry, 2004, Jan-13, Volume: 43, Issue:1

    Topics: Binding Sites; Catalysis; Crystallography, X-Ray; Enzyme Inhibitors; Humans; Phosphates; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; Recombinant Proteins; Ribitol

2004
Assignment of downfield proton resonances in purine nucleoside phosphorylase immucillin-H complex by saturation-transferred NOEs.
    Biochemistry, 2004, Feb-24, Volume: 43, Issue:7

    Topics: Binding, Competitive; Catalysis; Enzyme Activation; Enzyme Inhibitors; Humans; Hydrogen Bonding; Nuclear Magnetic Resonance, Biomolecular; Protein Binding; Protons; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; Recombinant Proteins; Solutions; Thermodynamics

2004
Plasmodium falciparum purine nucleoside phosphorylase: crystal structures, immucillin inhibitors, and dual catalytic function.
    The Journal of biological chemistry, 2004, Apr-30, Volume: 279, Issue:18

    Topics: Animals; Catalysis; Catalytic Domain; Crystallography, X-Ray; Enzyme Inhibitors; Humans; Hydrophobic and Hydrophilic Interactions; Methylthioinosine; Molecular Structure; Plasmodium falciparum; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles

2004
Targeting the polyamine pathway with transition-state analogue inhibitors of 5'-methylthioadenosine phosphorylase.
    Journal of medicinal chemistry, 2004, Jun-03, Volume: 47, Issue:12

    Topics: Adenine; Humans; Polyamines; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; Pyrrolidines; Stereoisomerism; Structure-Activity Relationship

2004
Activating the phosphate nucleophile at the catalytic site of purine nucleoside phosphorylase: a vibrational spectroscopic study.
    Journal of the American Chemical Society, 2004, Aug-11, Volume: 126, Issue:31

    Topics: Animals; Binding Sites; Catalysis; Cattle; Humans; Hydrogen Bonding; Kinetics; Organophosphates; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Thermodynamics

2004
Glutathione-dependent reduction of arsenate in human erythrocytes--a process independent of purine nucleoside phosphorylase.
    Toxicological sciences : an official journal of the Society of Toxicology, 2004, Volume: 82, Issue:2

    Topics: Arsenates; Arsenite Transporting ATPases; Blood Glucose; Dithiothreitol; Erythrocytes; Ferricyanides; Glucose Oxidase; Glutathione; Humans; In Vitro Techniques; Inosine; Ion Pumps; Multienzyme Complexes; NADP; Oxidation-Reduction; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; Pyruvic Acid; Spectrophotometry, Atomic

2004
New catalytic mechanism for human purine nucleoside phosphorylase.
    Biochemical and biophysical research communications, 2005, Feb-18, Volume: 327, Issue:3

    Topics: Acyclovir; Binding Sites; Catalysis; Crystallography, X-Ray; Enzyme Inhibitors; Humans; Models, Molecular; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles

2005
Structural rationale for the affinity of pico- and femtomolar transition state analogues of Escherichia coli 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase.
    The Journal of biological chemistry, 2005, May-06, Volume: 280, Issue:18

    Topics: Deoxyadenosines; Enzyme Inhibitors; Escherichia coli; Models, Molecular; N-Glycosyl Hydrolases; Purine Nucleosides; Pyrimidinones; Pyrroles; Thionucleosides

2005
Energetic mapping of transition state analogue interactions with human and Plasmodium falciparum purine nucleoside phosphorylases.
    The Journal of biological chemistry, 2005, Aug-26, Volume: 280, Issue:34

    Topics: Animals; Aspartic Acid; Cattle; Humans; Hydrogen-Ion Concentration; Kinetics; Models, Chemical; Plasmodium falciparum; Polyamines; Protein Binding; Protein Structure, Tertiary; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Purines; Pyrimidinones; Pyrroles; Static Electricity; Substrate Specificity; T-Lymphocytes

2005
Structure of human PNP complexed with ligands.
    Acta crystallographica. Section D, Biological crystallography, 2005, Volume: 61, Issue:Pt 7

    Topics: Azaguanine; Binding Sites; Crystallography, X-Ray; Guanine; Guanosine; Humans; Inosine; Ligands; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles

2005
Synthesis and evaluation of tricyclic pyrrolopyrimidinones as dipeptide mimetics: inhibition of interleukin-1beta-converting enzyme.
    Bioorganic & medicinal chemistry letters, 2005, Oct-01, Volume: 15, Issue:19

    Topics: Caspase Inhibitors; Dipeptides; Enzyme Inhibitors; Heterocyclic Compounds, 3-Ring; Humans; Immunologic Factors; Inhibitory Concentration 50; Molecular Mimicry; Monocytes; Pyrimidinones; Pyrroles; Structure-Activity Relationship

2005
Synthesis of classical, four-carbon bridged 5-substituted furo[2,3-d]pyrimidine and 6-substituted pyrrolo[2,3-d]pyrimidine analogues as antifolates.
    Journal of medicinal chemistry, 2005, Aug-11, Volume: 48, Issue:16

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Folic Acid Antagonists; Furans; Glutamic Acid; Humans; Peptide Synthases; Pyrimidines; Pyrimidinones; Pyrroles; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase

2005
Synthesis and hepatic transport of strongly fluorescent cholephilic dipyrrinones.
    The Journal of organic chemistry, 2005, Oct-14, Volume: 70, Issue:21

    Topics: Animals; Bile; Bilirubin; Colchicine; Drug Evaluation, Preclinical; Feasibility Studies; Fluorescent Dyes; Liver; Liver Diseases; Male; Mitochondrial Proteins; Pyrimidinones; Pyrroles; Rats; Rats, Gunn; Rats, Sprague-Dawley; Ribosomal Proteins; Saccharomyces cerevisiae Proteins; Spectrometry, Fluorescence; Sulfonic Acids; Urine

2005
3-Arylpiperazinylethyl-1H-pyrrolo[2,3-d]pyrimidine-2,4(3H,7H)-dione derivatives as novel, high-affinity and selective alpha(1)-adrenoceptor ligands.
    Bioorganic & medicinal chemistry letters, 2006, Jan-01, Volume: 16, Issue:1

    Topics: Chlorine; Dopamine Agents; Dose-Response Relationship, Drug; Humans; Kinetics; Ligands; Magnetic Resonance Spectroscopy; Models, Chemical; Piperazines; Protein Binding; Pyrimidinones; Pyrroles; Receptors, Adrenergic, alpha-1; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Time Factors

2006
Dual inhibitors of thymidylate synthase and dihydrofolate reductase as antitumor agents: design, synthesis, and biological evaluation of classical and nonclassical pyrrolo[2,3-d]pyrimidine antifolates(1).
    Journal of medicinal chemistry, 2006, Feb-09, Volume: 49, Issue:3

    Topics: Antineoplastic Agents; Binding Sites; Cell Line, Tumor; Drug Screening Assays, Antitumor; Escherichia coli; Folic Acid Antagonists; Glutamates; Humans; Models, Molecular; Pyrimidines; Pyrimidinones; Pyrroles; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Thermodynamics; Thymidylate Synthase

2006
Crystallization and preliminary X-ray characterization of the nitrile reductase QueF: a queuosine-biosynthesis enzyme.
    Acta crystallographica. Section F, Structural biology and crystallization communications, 2005, Oct-01, Volume: 61, Issue:Pt 10

    Topics: Bacillus subtilis; Catalysis; Computational Biology; Crystallization; Crystallography, X-Ray; GTP Cyclohydrolase; Guanine; Models, Chemical; Models, Molecular; NADP; Nucleoside Q; Oxidoreductases; Protein Conformation; Protein Isoforms; Protein Structure, Tertiary; Pyrimidinones; Pyrroles; RNA Processing, Post-Transcriptional; RNA, Transfer; X-Ray Diffraction

2005
Synthesis of non-nucleosides: 7- and 1,3-substituents of new pyrrolo[2,3-d]pyrimidin-4-ones on antiviral activity.
    Archiv der Pharmazie, 2006, Volume: 339, Issue:4

    Topics: Animals; Antiviral Agents; Chlorocebus aethiops; Herpesvirus 2, Human; Microbial Sensitivity Tests; Pyrimidinones; Pyrroles; Structure-Activity Relationship; Vero Cells; Viral Plaque Assay

2006
Transition-state complex of the purine-specific nucleoside hydrolase of T. vivax: enzyme conformational changes and implications for catalysis.
    Journal of molecular biology, 2006, Jun-02, Volume: 359, Issue:2

    Topics: Animals; Binding Sites; Crystallography, X-Ray; Ligands; Models, Molecular; Molecular Structure; N-Glycosyl Hydrolases; Protein Folding; Protein Structure, Quaternary; Protein Structure, Secondary; Purine Nucleosides; Pyrimidinones; Pyrroles; Trypanosoma vivax

2006
Forodesine, an inhibitor of purine nucleoside phosphorylase, induces apoptosis in chronic lymphocytic leukemia cells.
    Blood, 2006, Oct-01, Volume: 108, Issue:7

    Topics: Antineoplastic Agents; Apoptosis; B-Lymphocytes; Caspases; DNA Damage; Enzyme Inhibitors; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphocytes; Mitochondria; Phosphorylation; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; T-Lymphocytes; Tumor Suppressor Protein p53

2006
Simplified analogues of immucillin-G retain potent human purine nucleoside phosphorylase inhibitory activity.
    Journal of medicinal chemistry, 2006, Oct-05, Volume: 49, Issue:20

    Topics: Antineoplastic Agents; Cell Line; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Piperidines; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; Pyrrolidines; Structure-Activity Relationship

2006
A riboswitch selective for the queuosine precursor preQ1 contains an unusually small aptamer domain.
    Nature structural & molecular biology, 2007, Volume: 14, Issue:4

    Topics: 5' Untranslated Regions; Aptamers, Nucleotide; Bacillus subtilis; Base Pairing; Base Sequence; Conserved Sequence; Dialysis; Gene Expression Regulation, Bacterial; Genes, Bacterial; Molecular Sequence Data; Nucleoside Q; Phylogeny; Pyrimidinones; Pyrroles; Regulatory Sequences, Ribonucleic Acid; RNA, Bacterial

2007
Site-specific modification of Shigella flexneri virF mRNA by tRNA-guanine transglycosylase in vitro.
    Nucleic acids research, 2007, Volume: 35, Issue:14

    Topics: Amino Acid Sequence; Anticodon; Bacterial Proteins; Base Sequence; Escherichia coli; Escherichia coli Proteins; Kinetics; Molecular Sequence Data; Pentosyltransferases; Plasmids; Pyrimidinones; Pyrroles; RNA, Messenger; RNA, Transfer, Tyr; Shigella flexneri; Substrate Specificity; Transcription Factors; Transcription, Genetic

2007
Identification of two new synthetic histone deacetylase inhibitors that modulate globin gene expression in erythroid cells from healthy donors and patients with thalassemia.
    Molecular pharmacology, 2007, Volume: 72, Issue:5

    Topics: Blood Donors; Enzyme Inhibitors; Erythroblasts; Gene Expression; Globins; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Pyrimidinones; Pyrroles; Thalassemia; Tubulin

2007
CG base pair recognition within DNA triple helices using N-methyl-3H-pyrrolo[2,3-d]pyrimidin-2(7H)-one nucleoside analogues.
    Nucleosides, nucleotides & nucleic acids, 2007, Volume: 26, Issue:10-12

    Topics: Base Pairing; Cytosine; DNA; Guanine; Hydrogen Bonding; Nucleosides; Pyrimidinones; Pyrroles

2007
Aurora kinase A inhibitors: identification, SAR exploration and molecular modeling of 6,7-dihydro-4H-pyrazolo-[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-dione scaffold.
    Bioorganic & medicinal chemistry letters, 2008, Mar-01, Volume: 18, Issue:5

    Topics: Aurora Kinases; Binding Sites; Models, Molecular; Molecular Structure; Protein Serine-Threonine Kinases; Pyrazoles; Pyrimidinones; Pyrroles; Structure-Activity Relationship

2008
Confirmation of a second natural preQ1 aptamer class in Streptococcaceae bacteria.
    RNA (New York, N.Y.), 2008, Volume: 14, Issue:4

    Topics: 5' Untranslated Regions; Aptamers, Nucleotide; Base Sequence; Binding Sites; Computational Biology; Genes, Bacterial; Kinetics; Ligands; Models, Molecular; Molecular Sequence Data; Mutation; Nucleic Acid Conformation; Phylogeny; Pyrimidinones; Pyrroles; RNA, Bacterial; Sequence Homology, Nucleic Acid; Streptococcaceae; Streptococcus pneumoniae

2008
Crystal structure of QueC from Bacillus subtilis: an enzyme involved in preQ1 biosynthesis.
    Proteins, 2008, Aug-15, Volume: 72, Issue:3

    Topics: Bacillus subtilis; Bacterial Proteins; Crystallography, X-Ray; Models, Molecular; Protein Structure, Secondary; Pyrimidinones; Pyrroles

2008
A rapid and sensitive LC-MS/MS assay to quantify yonkenafil in rat plasma with application to preclinical pharmacokinetics studies.
    Journal of pharmaceutical and biomedical analysis, 2008, Aug-05, Volume: 47, Issue:4-5

    Topics: Acetates; Administration, Oral; Administration, Sublingual; Animals; Biological Availability; Buffers; Chromatography, Liquid; Cyclic Nucleotide Phosphodiesterases, Type 5; Drug Evaluation, Preclinical; Drug Stability; Fasting; Hydrogen-Ion Concentration; Injections, Intravenous; Male; Methanol; Molecular Structure; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Pyrimidinones; Pyrroles; Quality Control; Random Allocation; Rats; Rats, Wistar; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Time Factors

2008
Pyrrolo-pyrimidones: a novel class of MK2 inhibitors with potent cellular activity.
    Bioorganic & medicinal chemistry letters, 2008, Dec-01, Volume: 18, Issue:23

    Topics: Arthritis, Rheumatoid; Combinatorial Chemistry Techniques; Cytokines; Dose-Response Relationship, Drug; Drug Design; HSP27 Heat-Shock Proteins; Humans; Intracellular Signaling Peptides and Proteins; Leukocytes, Mononuclear; Lipopolysaccharides; Molecular Structure; Monocytes; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Pyrimidinones; Pyrroles; Tumor Necrosis Factor-alpha

2008
The structural basis for recognition of the PreQ0 metabolite by an unusually small riboswitch aptamer domain.
    The Journal of biological chemistry, 2009, Apr-24, Volume: 284, Issue:17

    Topics: Aptamers, Nucleotide; Bacillus subtilis; Base Pairing; Binding Sites; Crystallography, X-Ray; Electrons; Hydrogen Bonding; Ligands; Models, Chemical; Models, Molecular; Nucleic Acid Conformation; Protein Conformation; Protein Structure, Tertiary; Pyrimidinones; Pyrroles; Thermoanaerobacter

2009
Evidence for pseudoknot formation of class I preQ1 riboswitch aptamers.
    Chembiochem : a European journal of chemical biology, 2009, May-04, Volume: 10, Issue:7

    Topics: 5' Untranslated Regions; Aptamers, Nucleotide; Base Pairing; Base Sequence; Fusobacterium nucleatum; Mutation; Nucleic Acid Conformation; Pyrimidinones; Pyrroles; Regulatory Sequences, Ribonucleic Acid; RNA, Bacterial; RNA, Transfer

2009
Intramolecular formal [4 + 2] cycloaddition of nitriles with amides triggered by TMSOTf/Et3N: highly efficient construction of pyrrolo[1,2-a]pyrimidin-4(6H)-ones.
    The Journal of organic chemistry, 2009, Aug-07, Volume: 74, Issue:15

    Topics: Amides; Cyclization; Ethylamines; Mesylates; Molecular Structure; Nitriles; Pyrimidinones; Pyrroles; Stereoisomerism; Trimethylsilyl Compounds

2009
Synthesis and biological activity of N(4)-phenylsubstituted-6-(2,4-dichloro phenylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as vascular endothelial growth factor receptor-2 inhibitors and antiangiogenic and antitumor agents.
    Bioorganic & medicinal chemistry, 2010, May-15, Volume: 18, Issue:10

    Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Cell Line, Tumor; Diamines; Indoles; Male; Melanoma; Mice; Mice, Nude; Molecular Structure; Phosphorylation; Pyrimidines; Pyrimidinones; Pyrroles; Structure-Activity Relationship; Vascular Endothelial Growth Factor Receptor-2

2010
Folding of a transcriptionally acting preQ1 riboswitch.
    Proceedings of the National Academy of Sciences of the United States of America, 2010, Jun-15, Volume: 107, Issue:24

    Topics: Aptamers, Nucleotide; Base Sequence; Fusobacterium nucleatum; Kinetics; Ligands; Magnetic Resonance Spectroscopy; Models, Molecular; Nucleic Acid Conformation; Pyrimidinones; Pyrroles; RNA, Bacterial; RNA, Messenger; Spectrometry, Fluorescence

2010
Two new amide alkaloids with anti-leukaemia activities from Aconitum taipeicum.
    Fitoterapia, 2010, Volume: 81, Issue:8

    Topics: Aconitum; Alkaloids; Animals; Antineoplastic Agents, Phytogenic; HL-60 Cells; Humans; Leukemia; Molecular Structure; Plant Roots; Pyrimidinones; Pyrroles

2010
Evolution of eukaryal tRNA-guanine transglycosylase: insight gained from the heterocyclic substrate recognition by the wild-type and mutant human and Escherichia coli tRNA-guanine transglycosylases.
    Nucleic acids research, 2011, Volume: 39, Issue:7

    Topics: Amino Acid Sequence; Escherichia coli; Evolution, Molecular; Guanine; Humans; Kinetics; Molecular Sequence Data; Mutation; Pentosyltransferases; Phylogeny; Pyrimidinones; Pyrroles; Sequence Homology, Amino Acid; Substrate Specificity

2011
8-Aza-7,9-dideazaxanthine acyclic nucleoside phosphonate inhibitors of thymidine phosphorylase.
    Bioorganic & medicinal chemistry letters, 2011, Jan-15, Volume: 21, Issue:2

    Topics: Enzyme Inhibitors; Escherichia coli; Female; Humans; Placenta; Pregnancy; Pyrimidinones; Pyrroles; Recombinant Proteins; Structure-Activity Relationship; Thymidine Phosphorylase

2011
Atomic-scale characterization of conformational changes in the preQ₁ riboswitch aptamer upon ligand binding.
    Journal of molecular graphics & modelling, 2011, Volume: 30

    Topics: 2-Aminopurine; Aptamers, Nucleotide; Molecular Dynamics Simulation; Nucleic Acid Conformation; Pyrimidinones; Pyrroles; Riboswitch; RNA; Spectrometry, Fluorescence; Surface Properties

2011
Unraveling the structural complexity in a single-stranded RNA tail: implications for efficient ligand binding in the prequeuosine riboswitch.
    Nucleic acids research, 2012, Volume: 40, Issue:3

    Topics: Adenine; Ligands; Molecular Dynamics Simulation; Mutation; Nuclear Magnetic Resonance, Biomolecular; Nucleic Acid Conformation; Pyrimidinones; Pyrroles; Riboswitch; RNA; RNA Stability

2012
Myeloperoxidase inhibition ameliorates multiple system atrophy-like degeneration in a transgenic mouse model.
    Neurotoxicity research, 2012, Volume: 21, Issue:4

    Topics: Aged; alpha-Synuclein; Animals; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gliosis; Humans; Male; Mice; Mice, Transgenic; Microglia; Middle Aged; Motor Activity; Multiple System Atrophy; Nerve Degeneration; Peroxidase; Pyrimidinones; Pyrroles

2012
Discovery of P2X3 selective antagonists for the treatment of chronic pain.
    Bioorganic & medicinal chemistry letters, 2012, Apr-01, Volume: 22, Issue:7

    Topics: Analgesics; Animals; Chronic Pain; Dose-Response Relationship, Drug; High-Throughput Screening Assays; Humans; Injections, Spinal; Injections, Subcutaneous; Purinergic P2 Receptor Antagonists; Pyrimidinones; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2X3; Small Molecule Libraries

2012
Investigating the prevalence of queuine in Escherichia coli RNA via incorporation of the tritium-labeled precursor, preQ(1).
    Biochemical and biophysical research communications, 2012, Aug-17, Volume: 425, Issue:1

    Topics: Acrylic Resins; Electrophoresis, Agar Gel; Escherichia coli; Guanine; Isotope Labeling; Pyrimidinones; Pyrroles; RNA Processing, Post-Transcriptional; RNA, Bacterial; RNA, Transfer; Tritium

2012
Concise and efficient syntheses of preQ1 base, Q base, and (ent)-Q base.
    Organic & biomolecular chemistry, 2012, Nov-21, Volume: 10, Issue:43

    Topics: Guanine; Molecular Structure; Pyrimidinones; Pyrroles

2012
Expression and characterization of the nitrile reductase queF from E. coli.
    Enzyme and microbial technology, 2013, Mar-05, Volume: 52, Issue:3

    Topics: Bacillus subtilis; Base Sequence; Catalytic Domain; Enzyme Stability; Escherichia coli K12; Escherichia coli Proteins; Genes, Bacterial; Hydrogen-Ion Concentration; Kinetics; Models, Molecular; Molecular Sequence Data; NADP; Nuclear Magnetic Resonance, Biomolecular; Nucleoside Q; Oxidoreductases; Protein Conformation; Pyrimidinones; Pyrroles; Recombinant Fusion Proteins; Substrate Specificity; Temperature

2013
Targeting the substrate binding site of E. coli nitrile reductase QueF by modeling, substrate and enzyme engineering.
    Chemistry (Weinheim an der Bergstrasse, Germany), 2013, May-27, Volume: 19, Issue:22

    Topics: Binding Sites; Catalysis; Catalytic Domain; Escherichia coli; Escherichia coli Proteins; Nucleoside Q; Oxidation-Reduction; Oxidoreductases; Pyrimidinones; Pyrroles; Substrate Specificity

2013
Single transcriptional and translational preQ1 riboswitches adopt similar pre-folded ensembles that follow distinct folding pathways into the same ligand-bound structure.
    Nucleic acids research, 2013, Volume: 41, Issue:22

    Topics: Bacillus subtilis; Fluorescence Resonance Energy Transfer; Ligands; Nucleic Acid Conformation; Protein Biosynthesis; Pyrimidinones; Pyrroles; Riboswitch; RNA Folding; Thermoanaerobacter; Transcription, Genetic

2013
PreQ0 base, an unusual metabolite with anti-cancer activity from Streptomyces qinglanensis 172205.
    Anti-cancer agents in medicinal chemistry, 2015, Volume: 15, Issue:3

    Topics: Antineoplastic Agents; Cell Proliferation; Computational Biology; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; HeLa Cells; Hep G2 Cells; Humans; Molecular Structure; Pyrimidinones; Pyrroles; Streptomyces; Structure-Activity Relationship

2015
The potent Cdc7-Dbf4 (DDK) kinase inhibitor XL413 has limited activity in many cancer cell lines and discovery of potential new DDK inhibitor scaffolds.
    PloS one, 2014, Volume: 9, Issue:11

    Topics: Apoptosis; Biological Availability; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Drug Repositioning; Gene Expression Regulation, Neoplastic; HCT116 Cells; HeLa Cells; Humans; Piperidones; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrimidinones; Pyrroles

2014
ITC analysis of ligand binding to preQ₁ riboswitches.
    Methods in enzymology, 2014, Volume: 549

    Topics: Calorimetry; Ligands; Models, Molecular; Pyrimidinones; Pyrroles; Riboswitch; Thermodynamics

2014
Development of rapid multistep carbon-11 radiosynthesis of the myeloperoxidase inhibitor AZD3241 to assess brain exposure by PET microdosing.
    Nuclear medicine and biology, 2015, Volume: 42, Issue:6

    Topics: Animals; Brain; Carbon Radioisotopes; Dose-Response Relationship, Radiation; Female; Humans; Macaca fascicularis; Magnetic Resonance Imaging; Male; Peroxidase; Positron-Emission Tomography; Pyrimidinones; Pyrroles; Radiopharmaceuticals

2015
Immucillins Impair Leishmania (L.) infantum chagasi and Leishmania (L.) amazonensis Multiplication In Vitro.
    PloS one, 2015, Volume: 10, Issue:4

    Topics: Adenine; Adenosine; Animals; Antiprotozoal Agents; Cell Proliferation; Enzyme Inhibitors; Female; Humans; In Vitro Techniques; Kinetics; Leishmania infantum; Leishmania mexicana; Leishmaniasis, Cutaneous; Leishmaniasis, Visceral; Mice; Mice, Inbred BALB C; Microscopy, Electron, Transmission; N-Glycosyl Hydrolases; Purine Nucleosides; Pyrimidinones; Pyrroles; Pyrrolidines

2015
Structural analysis of a class III preQ1 riboswitch reveals an aptamer distant from a ribosome-binding site regulated by fast dynamics.
    Proceedings of the National Academy of Sciences of the United States of America, 2015, Jul-07, Volume: 112, Issue:27

    Topics: Aptamers, Nucleotide; Base Sequence; Binding Sites; Clostridium; Crystallography, X-Ray; Kinetics; Molecular Dynamics Simulation; Molecular Sequence Data; Nucleoside Q; Pyrimidinones; Pyrroles; Ribosomes; Riboswitch; RNA Folding; RNA, Bacterial; Thermodynamics

2015
Rational Re-engineering of a Transcriptional Silencing PreQ1 Riboswitch.
    Journal of the American Chemical Society, 2015, Jul-22, Volume: 137, Issue:28

    Topics: Aptamers, Nucleotide; Bacillus subtilis; Base Sequence; Gene Expression Regulation, Bacterial; Gene Silencing; Genetic Engineering; Mutagenesis; Pyrimidinones; Pyrroles; Riboswitch; Synthetic Biology; Transcriptional Activation

2015
NF-κB Upregulates Type 5 Phosphodiesterase in N9 Microglial Cells: Inhibition by Sildenafil and Yonkenafil.
    Molecular neurobiology, 2016, Volume: 53, Issue:4

    Topics: Animals; Cell Line; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation, Enzymologic; Humans; Inflammation Mediators; Lipopolysaccharides; Mice; Microglia; Neurotoxins; NF-kappa B; Phosphodiesterase Inhibitors; Pyrimidinones; Pyrroles; RNA Interference; RNA, Messenger; Sildenafil Citrate; Up-Regulation

2016
Failure of Neuroprotection Despite Microglial Suppression by Delayed-Start Myeloperoxidase Inhibition in a Model of Advanced Multiple System Atrophy: Clinical Implications.
    Neurotoxicity research, 2015, Volume: 28, Issue:3

    Topics: alpha-Synuclein; Animals; Brain; Disease Models, Animal; Enzyme Inhibitors; Humans; Male; Mice, Transgenic; Microglia; Motor Activity; Multiple System Atrophy; Myelin Proteolipid Protein; Neurons; Neuroprotective Agents; Nitro Compounds; Peroxidase; Propionates; Pyrimidinones; Pyrroles; Severity of Illness Index; Treatment Outcome

2015
Evaluation of In Vitro Activity of the Class I PI3K Inhibitor Buparlisib (BKM120) in Pediatric Bone and Soft Tissue Sarcomas.
    PloS one, 2015, Volume: 10, Issue:9

    Topics: Aminopyridines; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cells, Cultured; Class I Phosphatidylinositol 3-Kinases; Drug Synergism; Extracellular Signal-Regulated MAP Kinases; Humans; Mechanistic Target of Rapamycin Complex 1; Morpholines; Multiprotein Complexes; Mutation; Osteosarcoma; Phosphorylation; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Pyridones; Pyrimidines; Pyrimidinones; Pyrroles; Sarcoma; Signal Transduction; TOR Serine-Threonine Kinases

2015
Preclinical Evidence That Trametinib Enhances the Response to Antiangiogenic Tyrosine Kinase Inhibitors in Renal Cell Carcinoma.
    Molecular cancer therapeutics, 2016, Volume: 15, Issue:1

    Topics: Angiogenesis Inhibitors; Animals; Carcinoma, Renal Cell; Cell Line, Tumor; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Resistance, Neoplasm; Drug Synergism; Endothelial Cells; Female; Humans; Indoles; Kidney Neoplasms; MAP Kinase Signaling System; Neovascularization, Pathologic; Protein Kinase Inhibitors; Pyridones; Pyrimidinones; Pyrroles; Sunitinib; Von Hippel-Lindau Tumor Suppressor Protein; Xenograft Model Antitumor Assays

2016
Rapid and sensitive liquid chromatography with tandem mass spectrometry method for the simultaneous quantification of yonkenafil and its major metabolites in rat plasma.
    Journal of separation science, 2016, Volume: 39, Issue:19

    Topics: Animals; Chromatography, High Pressure Liquid; Molecular Structure; Plasma; Pyrimidinones; Pyrroles; Rats; Rats, Wistar; Sensitivity and Specificity; Tandem Mass Spectrometry

2016
Crystal structure of the archaeosine synthase QueF-like-Insights into amidino transfer and tRNA recognition by the tunnel fold.
    Proteins, 2017, Volume: 85, Issue:1

    Topics: Amidinotransferases; Amino Acid Sequence; Archaeal Proteins; Catalytic Domain; Cloning, Molecular; Crystallography, X-Ray; Escherichia coli; Gene Expression; Guanosine; Molecular Docking Simulation; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Protein Multimerization; Protein Subunits; Pyrimidinones; Pyrobaculum; Pyrroles; Recombinant Proteins; RNA Processing, Post-Transcriptional; RNA, Archaeal; RNA, Transfer; Sequence Alignment; Sequence Homology, Amino Acid; Substrate Specificity

2017
Structure guided design of a series of selective pyrrolopyrimidinone MARK inhibitors.
    Bioorganic & medicinal chemistry letters, 2017, 01-01, Volume: 27, Issue:1

    Topics: Alzheimer Disease; Cell Line; Crystallography, X-Ray; Dose-Response Relationship, Drug; Drug Design; Humans; Models, Molecular; Molecular Structure; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrimidinones; Pyrroles; Structure-Activity Relationship

2017
Benzopyrimido-pyrrolo-oxazine-dione CFTR inhibitor (R)-BPO-27 for antisecretory therapy of diarrheas caused by bacterial enterotoxins.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2017, Volume: 31, Issue:2

    Topics: Animals; Cystic Fibrosis Transmembrane Conductance Regulator; Diarrhea; Dose-Response Relationship, Drug; Female; Humans; Intestines; Mice; Molecular Structure; Oxazines; Pyrimidinones; Pyrroles

2017
MARK inhibitors: Declaring a No-Go decision on a chemical series based on extensive DMPK experimentation.
    Bioorganic & medicinal chemistry letters, 2017, 01-01, Volume: 27, Issue:1

    Topics: Alzheimer Disease; Animals; Dose-Response Relationship, Drug; Humans; Isoenzymes; Molecular Structure; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrimidinones; Pyrroles; Rats; Structure-Activity Relationship

2017
Characterization of Engineered PreQ1 Riboswitches for Inducible Gene Regulation in Mycobacteria.
    Journal of bacteriology, 2017, 03-15, Volume: 199, Issue:6

    Topics: Bacillus subtilis; Base Sequence; Gene Expression Regulation, Bacterial; Genetic Engineering; Lacticaseibacillus rhamnosus; Mycobacterium smegmatis; Nucleoside Q; Pyrimidinones; Pyrroles; Riboswitch; Thermoanaerobacter

2017
In vivo modification of tRNA with an artificial nucleobase leads to full disease remission in an animal model of multiple sclerosis.
    Nucleic acids research, 2017, 02-28, Volume: 45, Issue:4

    Topics: Animals; Brain; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Genetic Therapy; Mice, Inbred C57BL; Multiple Sclerosis; Pentosyltransferases; Pyrimidinones; Pyrroles; RNA, Transfer; Thioguanine

2017
Biophysical properties, thermal stability and functional impact of 8-oxo-7,8-dihydroguanine on oligonucleotides of RNA-a study of duplex, hairpins and the aptamer for preQ1 as models.
    Nucleic acids research, 2017, 02-28, Volume: 45, Issue:4

    Topics: Aptamers, Nucleotide; DNA; Guanine; Inverted Repeat Sequences; Magnetic Resonance Spectroscopy; Nucleic Acid Conformation; Oligoribonucleotides; Pyrimidinones; Pyrroles

2017
DNA Replication Dynamics and Cellular Responses to ATP Competitive CDC7 Kinase Inhibitors.
    ACS chemical biology, 2017, 07-21, Volume: 12, Issue:7

    Topics: Adenosine Triphosphate; Binding, Competitive; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; DNA Replication; Female; Humans; Phosphorylation; Piperidones; Protein Serine-Threonine Kinases; Pyrimidinones; Pyrroles

2017
Moving Synergistically Acting Drug Combinations to the Clinic by Comparing Sequential versus Simultaneous Drug Administrations.
    Molecular pharmacology, 2018, Volume: 93, Issue:3

    Topics: Animals; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Administration Schedule; Drug Antagonism; Drug Screening Assays, Antitumor; Drug Synergism; Drug Therapy, Combination; Forkhead Box Protein M1; Gene Expression Regulation, Neoplastic; Humans; Mice; Multiple Myeloma; Pyrazoles; Pyrimidines; Pyrimidinones; Pyrroles; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays

2018
High-Yield Spin Labeling of Long RNAs for Electron Paramagnetic Resonance Spectroscopy.
    Biochemistry, 2018, 05-22, Volume: 57, Issue:20

    Topics: Aptamers, Nucleotide; Click Chemistry; Electron Spin Resonance Spectroscopy; Nucleic Acid Conformation; Pyrimidinones; Pyrroles; Riboswitch; RNA; Spin Labels

2018
Population Pharmacokinetic Modeling With Enterohepatic Circulation for AZD3241 in Healthy Subjects and Patients With Multiple System Atrophy.
    Journal of clinical pharmacology, 2018, Volume: 58, Issue:11

    Topics: Adult; Aged; Bile; Enterohepatic Circulation; Female; Healthy Volunteers; Humans; Male; Middle Aged; Models, Biological; Multiple System Atrophy; Peroxidase; Pyrimidinones; Pyrroles; Random Allocation

2018
Synthesis and molecular modelling studies of pyrimidinones and pyrrolo[3,4-d]-pyrimidinodiones as new antiplasmodial compounds.
    Memorias do Instituto Oswaldo Cruz, 2018, Volume: 113, Issue:8

    Topics: Animals; Antimalarials; Drug Design; Inhibitory Concentration 50; Mice; Models, Molecular; Parasitic Sensitivity Tests; Plasmodium berghei; Plasmodium falciparum; Pyrimidinones; Pyrroles; Structure-Activity Relationship

2018
Purin-6-one and pyrrolo[2,3-d]pyrimidin-4-one derivatives as potentiating agents of doxorubicin cytotoxicity.
    Future medicinal chemistry, 2018, Sep-01, Volume: 10, Issue:17

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Doxorubicin; Humans; Neoplasms; Purinones; Pyrimidinones; Pyrroles

2018
DDK Has a Primary Role in Processing Stalled Replication Forks to Initiate Downstream Checkpoint Signaling.
    Neoplasia (New York, N.Y.), 2018, Volume: 20, Issue:10

    Topics: Cell Cycle Proteins; Cell Line; Dimethyl Sulfoxide; DNA Repair Enzymes; DNA Replication; DNA, Single-Stranded; Etoposide; Exodeoxyribonucleases; Humans; Mitosis; Piperidones; Protein Serine-Threonine Kinases; Pyrimidinones; Pyrroles; Signal Transduction

2018
Observation of preQ
    RNA biology, 2019, Volume: 16, Issue:9

    Topics: Fluorescence Resonance Energy Transfer; Magnesium; Nucleic Acid Conformation; Nucleoside Q; Pyrimidines; Pyrimidinones; Pyrroles; Riboswitch; RNA, Transfer; Single Molecule Imaging

2019
Superior cellular activities of azido- over amino-functionalized ligands for engineered preQ
    RNA biology, 2018, Volume: 15, Issue:10

    Topics: Binding Sites; Escherichia coli; Gene Expression Regulation, Bacterial; Kinetics; Ligands; Nucleic Acid Conformation; Pyrimidinones; Pyrroles; Riboswitch; RNA Folding; Structure-Activity Relationship; Thermodynamics

2018
Intestinal epithelial potassium channels and CFTR chloride channels activated in ErbB tyrosine kinase inhibitor diarrhea.
    JCI insight, 2019, 02-21, Volume: 4, Issue:4

    Topics: Acetamides; Afatinib; Animals; Cell Membrane Permeability; Clotrimazole; Colon; Cystic Fibrosis Transmembrane Conductance Regulator; Diarrhea; Disease Models, Animal; Epithelial Cells; ErbB Receptors; Female; Humans; Intestinal Mucosa; Neoplasms; Oxazines; Potassium Channel Blockers; Potassium Channels; Protein Kinase Inhibitors; Pyrimidinones; Pyrroles; Rats; Trityl Compounds

2019
Inhibiting PNP for the therapy of hyperuricemia in Lesch-Nyhan disease: Preliminary in vitro studies with analogues of immucillin-G.
    Journal of inherited metabolic disease, 2019, Volume: 42, Issue:1

    Topics: Allopurinol; Cells, Cultured; Enzyme Inhibitors; Humans; Hyperuricemia; Hypoxanthine; Hypoxanthine Phosphoribosyltransferase; Lesch-Nyhan Syndrome; Purine-Nucleoside Phosphorylase; Purines; Pyrimidinones; Pyrroles; Reproducibility of Results; Uric Acid; Xanthine

2019
Synthetic ligands for PreQ
    Nature communications, 2019, 04-02, Volume: 10, Issue:1

    Topics: Aptamers, Nucleotide; Crystallography, X-Ray; Ligands; Nucleic Acid Conformation; Pyrimidinones; Pyrroles; Riboswitch; RNA Folding

2019
Discovery of Pyrrolo[3,2- d]pyrimidin-4-one Derivatives as a New Class of Potent and Cell-Active Inhibitors of P300/CBP-Associated Factor Bromodomain.
    Journal of medicinal chemistry, 2019, 05-09, Volume: 62, Issue:9

    Topics: Animals; Drug Discovery; Enzyme Inhibitors; Gene Expression; HEK293 Cells; Humans; Male; Mice; Microsomes, Liver; Molecular Structure; p300-CBP Transcription Factors; Protein Domains; Pyrimidinones; Pyrroles; Rats, Sprague-Dawley; Stereoisomerism; Structure-Activity Relationship

2019
Inhibition of CFTR-mediated intestinal chloride secretion as potential therapy for bile acid diarrhea.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019, Volume: 33, Issue:10

    Topics: Animals; Cell Line; Cells, Cultured; Chenodeoxycholic Acid; Chlorides; Cystic Fibrosis Transmembrane Conductance Regulator; Diarrhea; Female; Humans; Intestinal Mucosa; Intestinal Secretions; Mice; Oxazines; Pyrimidinones; Pyrroles; Rats; Rats, Sprague-Dawley

2019
Inhibition of PDE5 attenuates streptozotocin-induced neuroinflammation and tau hyperphosphorylation in a streptozotocin-treated rat model.
    Brain research, 2019, 11-01, Volume: 1722

    Topics: Alzheimer Disease; Animals; Disease Models, Animal; Encephalitis; Insulin; Male; Phosphodiesterase 5 Inhibitors; Phosphorylation; Pyrimidinones; Pyrroles; Rats, Wistar; Streptozocin; tau Proteins

2019
A Conformational Restriction Strategy for the Identification of a Highly Selective Pyrimido-pyrrolo-oxazine mTOR Inhibitor.
    Journal of medicinal chemistry, 2019, 09-26, Volume: 62, Issue:18

    Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Dogs; Drug Design; Humans; Inhibitory Concentration 50; Kinetics; Male; Mice; Molecular Conformation; Neoplasms; Oxazines; Protein Kinase Inhibitors; Pyrimidinones; Pyrroles; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; TOR Serine-Threonine Kinases

2019
Highlights from Gastro Update Europe - Budapest June 26-27, 2019.
    Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology, 2019, Volume: 20, Issue:3

    Topics: Celiac Disease; Clostridioides difficile; Colorectal Neoplasms; Endoscopy, Digestive System; Enterocolitis, Pseudomembranous; Foodborne Diseases; Gastroesophageal Reflux; Gastrointestinal Diseases; Humans; Pancreatic Intraductal Neoplasms; Pancreatitis; Proton Pump Inhibitors; Pyrimidinones; Pyrroles; Sulfonamides; Tetrahydroisoquinolines

2019
Quantum chemical and well-tempered metadynamics study to design adenine analogs for orthogonal Preq
    Journal of biomolecular structure & dynamics, 2020, Volume: 38, Issue:15

    Topics: Adenine; Nucleic Acid Conformation; Pyrimidinones; Pyrroles; Riboswitch

2020
Nucleobase mutants of a bacterial preQ
    The Journal of biological chemistry, 2020, 02-28, Volume: 295, Issue:9

    Topics: Base Sequence; Binding Sites; Gene Expression Regulation, Bacterial; Mutation; Pyrimidinones; Pyrroles; Riboswitch; RNA, Bacterial

2020
7-Deazaguanine modifications protect phage DNA from host restriction systems.
    Nature communications, 2019, 11-29, Volume: 10, Issue:1

    Topics: Archaeal Viruses; Bacteriophages; DNA; DNA Restriction Enzymes; Guanine; Pyrimidinones; Pyrroles

2019
Protein unties the pseudoknot: S1-mediated unfolding of RNA higher order structure.
    Nucleic acids research, 2020, 02-28, Volume: 48, Issue:4

    Topics: 2-Aminopurine; Binding Sites; Escherichia coli; Guanine; Ligands; Nucleic Acid Conformation; Pyrimidinones; Pyrroles; Ribosomal Proteins; Ribosomes; Riboswitch; RNA; RNA Folding; Single Molecule Imaging

2020
Conscious uncoupling of riboswitch functions.
    The Journal of biological chemistry, 2020, 02-28, Volume: 295, Issue:9

    Topics: Bacteria; Biophysical Phenomena; Gene Expression Regulation; Lacticaseibacillus rhamnosus; Ligands; Mutation; Nucleic Acid Conformation; Pyrimidinones; Pyrroles; Riboswitch

2020
    Cancer research, 2020, 08-15, Volume: 80, Issue:16

    Topics: Aminopyridines; Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Synergism; Genes, ras; Heterografts; Humans; Indoles; Male; MAP Kinase Signaling System; Mice, Inbred NOD; Mice, SCID; Mitogen-Activated Protein Kinase Kinases; Mutation; Neoplasm Recurrence, Local; Neuroblastoma; Piperidines; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Pyridones; Pyrimidines; Pyrimidinones; Pyrroles; Triazoles; Vemurafenib

2020
Detection of preQ0 deazaguanine modifications in bacteriophage CAjan DNA using Nanopore sequencing reveals same hypermodification at two distinct DNA motifs.
    Nucleic acids research, 2020, 10-09, Volume: 48, Issue:18

    Topics: Bacteriophages; Base Sequence; CRISPR-Cas Systems; DNA; DNA Restriction-Modification Enzymes; Escherichia coli; Gene Editing; Guanine; Humans; Nanopore Sequencing; Nucleotide Motifs; Pyrimidinones; Pyrroles; Siphoviridae

2020
Identification of Wee1 as a target in combination with avapritinib for gastrointestinal stromal tumor treatment.
    JCI insight, 2021, 01-25, Volume: 6, Issue:2

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Cycle Proteins; Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm; Female; Gastrointestinal Stromal Tumors; Humans; Male; Mice; Mice, SCID; Mutation; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-kit; Pyrazoles; Pyrimidinones; Pyrroles; Receptor, Platelet-Derived Growth Factor alpha; Signal Transduction; Triazines; Xenograft Model Antitumor Assays

2021
Synthesis and characterization of PNA oligomers containing preQ
    Bioorganic & medicinal chemistry letters, 2021, 05-01, Volume: 39

    Topics: Molecular Structure; Peptide Nucleic Acids; Pyrimidinones; Pyrroles

2021
A small RNA that cooperatively senses two stacked metabolites in one pocket for gene control.
    Nature communications, 2022, 01-11, Volume: 13, Issue:1

    Topics: Base Pairing; Cloning, Molecular; Crystallography, X-Ray; Escherichia coli; Gene Expression; Gene Expression Regulation, Bacterial; Genetic Vectors; Green Fluorescent Proteins; Neisseria gonorrhoeae; Nucleic Acid Conformation; Nucleoside Q; Pyrimidinones; Pyrroles; Recombinant Proteins; Riboswitch; RNA, Bacterial; RNA, Messenger

2022
Protein-Based Virtual Screening Tools Applied for RNA-Ligand Docking Identify New Binders of the preQ
    Journal of chemical information and modeling, 2022, 09-12, Volume: 62, Issue:17

    Topics: Ligands; Prospective Studies; Proteins; Pyrimidinones; Pyrroles; Riboswitch; RNA

2022