pyrroles has been researched along with pyrazines in 171 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (12.87) | 18.7374 |
| 1990's | 7 (4.09) | 18.2507 |
| 2000's | 49 (28.65) | 29.6817 |
| 2010's | 79 (46.20) | 24.3611 |
| 2020's | 14 (8.19) | 2.80 |
| Authors | Studies |
|---|---|
| Hayashi, M; Iguchi, Y; Iizuka, K; Kajiwara, I; Kawamura, M; Miyamoto, T; Nakazawa, M; Ohyama, I; Okada, T; Taniguchi, K; Tanouchi, T | 1 |
| Fotsch, C; St Jean, DJ | 1 |
| Chiche, P; Denizeau, JP; Derrida, JP; Sal, R | 1 |
| Levy, J; Malaisse, WJ | 1 |
| Chiavarelli, S; Gatta, F | 1 |
| Gröger, D; Johne, S; Syring, U | 1 |
| Ford, EJ | 1 |
| Bullock, G; Eakins, MN; Sawyer, BC; Slater, TF | 1 |
| Middleton, MC | 2 |
| Neurath, G | 1 |
| Deki, M; Yoshimura, M | 1 |
| Richard, JL | 1 |
| Fukuyama, T; Havel, M; Kishi, Y; Nakatsuka, S | 1 |
| Berk, S; Gisser, H | 1 |
| Fyvie, AA; Ronaldson, JW | 1 |
| Cardeilhac, PT; Colwell, WM; Nair, KP | 1 |
| Borsy, J; Gyenge, R; Tamási, G | 1 |
| Fang, VS | 1 |
| Abou-Gharbia, M; Freed, ME; McCaully, RJ; Silver, PJ; Wendt, RL | 1 |
| Corsico, N; Fontanella, L; Mariani, L; Occelli, E | 1 |
| De Fazio, G; Kudamatsu, M | 1 |
| Bian, SS; Chen, YL; Lee, H | 1 |
| Advenier, C; Bakdach, H; Bonnet, PA; Cui, YY; Michel, A; Naline, E | 1 |
| Berto, L; Bonnet, PA; Cortijo, J; Michel, A; Morcillo, EJ; Navarrete, C; Sanz, C; Villagrasa, V | 1 |
| Fulton, D; Kaminski, P; McGiff, JC; Quilley, J; Wolin, MS | 1 |
| Andronati, SA; Dyadenko, AI; Korotenko, TI; Mazurov, AA; Shapiro, YE; Sokolenko, NI; Voronina, TA | 1 |
| Brooks, EW; Mansbach, RS; Sanner, MA; Zorn, SH | 1 |
| Ames, JM; Hill, VM; Isaacs, NS; Ledward, DA | 1 |
| Clifford, JJ; Waddington, JL | 1 |
| Ansorena, D; Bello, J; Cid, C; Sanz, C | 1 |
| Adams, A; De Kimpe, N; Kersiene, M; Tehrani, KA; Venskutonis, R | 1 |
| Giles, FJ | 1 |
| Lee, KG; Ochi, H; Shibamoto, T; Yanagimoto, K | 1 |
| Bailly, C; Lansiaux, A | 1 |
| BERNARD, Y; RINALDI, R | 1 |
| Katayev, E; Lynch, VM; Pantos, GD; Sessler, JL | 1 |
| von Mehren, M | 1 |
| Fishbein, JC; Johnson, JK; Kensler, TW; Kwak, MK; Navamal, M; Petzer, JP | 1 |
| Shiotsu, Y | 1 |
| Copper, JE; French, KJ; Schrecengost, RS; Smith, CD; Xia, Z; Zhuang, Y | 1 |
| Jacquot, DE; Lindel, T; Mayer, P | 1 |
| Dallemagne, P; Déprez-Poulain, R; Forfar-Bares, I; Grellier, P; Guillon, J; Jarry, C; Labaied, M; Léger, JM; Lemaître, N; Péhourcq, F; Rochette, J; Sergheraert, C; Sonnet, P | 1 |
| Alvarez-Builla, J; Castellote, I; Fernández-Gadea, J; Vaquero, JJ | 1 |
| Jiang, Y; Yu, Q; Zeng, M; Zhang, B; Zhang, N; Zheng, K | 1 |
| Halbich, W; Kleineidam, CJ; Obermayer, M; Rössler, W | 1 |
| Anderson, KC; Berkers, C; Catley, L; Chao, TH; Chauhan, D; Hideshima, T; Letai, A; Li, G; Mitsiades, C; Mitsiades, N; Neuteboom, ST; Nicholson, B; Ovaa, H; Palladino, MA; Podar, K; Richardson, P; Velankar, M; Yasui, H | 1 |
| Cavanni, P; Di Fabio, R; Donati, D; Faedo, S; Maffeis, M; Marchioro, C; Micheli, F; Sabbatini, FM; Tranquillini, ME | 1 |
| Adams, DR; Benardeau, A; Bentley, JM; Bickerdike, MJ; Blench, TJ; Cliffe, IA; Dourish, C; Hebeisen, P; Kennett, GA; Knight, AR; Malcolm, CS; Mattei, P; Misra, A; Mizrahi, J; Monck, NJ; Plancher, JM; Richter, HG; Roever, S; Roffey, JR; Taylor, S; Vickers, SP | 1 |
| Abraham, NG; Bolognesi, M; Di Pascoli, M; Rodella, L; Sacerdoti, D; Turkseven, S | 1 |
| Durdaği, S; Karalti, O; Salzner, U | 1 |
| Bazemore, R; Greenberg, M; Harrison, C | 1 |
| Alves, WA; Córdoba de Torresi, SI; Fiorito, PA; Torresi, RM | 1 |
| Hurley, LM | 1 |
| Chandra, J; Keating, M; Krupnik, Y; McConkey, D; Palladino, M; Ruiz, S | 1 |
| Kurbanov, RD; Shek, AB; Tashkenbaeva, NF | 1 |
| Bernasconi, P; Calatroni, S; Crosetto, N; Dikic, I | 1 |
| Chao, TH; Cusack, JC; Liu, R; Neuteboom, ST; Niu, W; Palladino, MA; Palombella, VJ; Pien, C; Xia, L | 1 |
| Blank, JL; Bruzzese, FJ; Cao, Y; Daniels, JS; Dick, LR; Labutti, J; Mazzola, AM; Patil, AD; Reimer, CL; Rolfe, M; Solomon, MS; Stirling, M; Tian, Y; Tsu, CA; Weatherhead, GS; Williamson, MJ; Zhang, JX | 1 |
| Campo, E; Colomer, D; Pérez-Galán, P; Roué, G; Villamor, N | 1 |
| Anderson, KC; Brahmandam, M; Chauhan, D; Hideshima, T; Munshi, N; Palladino, MA; Podar, K; Richardson, P; Singh, A | 1 |
| Wang, F; Wang, J; Zhang, S | 1 |
| Acoca, S; Beauparlant, P; Bélec, L; Billot, X; Cluse, L; Goulet, D; Johnstone, RW; Marcellus, RC; Murthy Madiraju, SR; Nguyen, M; Purisima, E; Roulston, A; Serfass, L; Shore, GC; Viallet, J; Watson, M; Wiegmans, A | 1 |
| Bertani, B; Bozzoli, A; Cavanni, P; Crippa, L; Di Fabio, R; Donati, D; Marzorati, P; Merlo, G; Micheli, F; Paio, A; Perugini, L; Zarantonello, P | 1 |
| Anderson, KC; Azab, A; Azab, F; Burwick, N; Chauhan, D; Farag, M; Ghobrial, IM; Hideshima, T; Jia, X; Leleu, X; Melhem, M; Moreau, AS; Ngo, HT; Palladino, MA; Roccaro, AM; Runnels, J; Sacco, A; Treon, SP | 1 |
| Adams, A; De Kimpe, N; Polizzi, V; van Boekel, M | 1 |
| Bai, X; Dang, Q; Wen, D; Xiang, J; Xie, H | 1 |
| Baritaki, S; Berenson, J; Bonavida, B; Daniels, TR; Jazirehi, AR; Palladino, M; Penichet, ML; Spandidos, DA; Suzuki, E; Umezawa, K | 1 |
| Campo, E; Colomer, D; López-Guerra, M; Montserrat, E; Nguyen, M; Pérez-Galán, P; Roué, G; Shore, GC; Villamor, N | 1 |
| Cusack, JC; Houston, M; Liu, R; Ljungman, D; Palladino, MA; Sloss, CM; Wang, F; Xia, L | 1 |
| Chandra, J; Keating, MJ; Miller, CP; Palladino, M; Rudra, S; Wierda, WG | 1 |
| Chan, W; Heymach, J; McConkey, DJ; Wilkinson, M; Zhu, K | 1 |
| Fuchs, O; Kuzelova, K; Marinov, I; Provaznikova, D; Spicka, I | 1 |
| Tsukamoto, S; Yokosawa, H | 1 |
| Bach, S; Corbel, C; Goekjian, P; Gueyrard, D; Guiffant, D; Haddoub, R; Lemoine, J; Lozach, O; Meijer, L; Ratin, M | 1 |
| Chaintreau, A; Egger, J; Rochat, S | 1 |
| Schiff, D; van den Bent, MJ; Wen, PY | 1 |
| Orlowski, RZ; Shah, JJ | 1 |
| Baritaki, S; Berenson, J; Bonavida, B; Palladino, M; Yeung, K | 1 |
| Dunner, K; McConkey, DJ; Zhu, K | 1 |
| Aldarmaa, J; Molodavkin, GM | 1 |
| Gong, F; Gong, Q; Gu, H; Jin, X; Li, X; Yin, H; Yuan, B; Zhang, B; Zheng, F; Zhu, J | 1 |
| Arban, R; Bianchi, F; Buson, A; Cremonesi, S; Di Fabio, R; Gentile, G; Micheli, F; Pasquarello, A; Pozzan, A; Tarsi, L; Terreni, S; Tonelli, F | 1 |
| Chen, W; Hu, M; Wu, J; Yu, Y; Zou, H | 1 |
| Cailly, T; Charnay, Y; Dumas, N; Fabis, F; Lemaître, S; Millet, P; Rault, S | 1 |
| Kopecky, K; Kucera, R; Miletin, M; Novakova, V; Zimcik, P | 1 |
| Abal, L; Casanova, JM; Dolcet, X; Egido, R; Llombart-Cussac, A; Martí, RM; Matias-Guiu, X; Moreno, S; Puig, S; Santacana, M; Sorolla, A; Valls, J; Velasco, A; Vilella, R; Yeramian, A | 1 |
| De Nanteuil, G; Gloanec, P; Marx, I; Mennecier, P; Rupin, A; Vallez, MO; Verbeuren, TJ | 1 |
| Goldschmidt, H; Moehler, T | 1 |
| Arango, BA; Cohen, EE; Perez, CA; Raez, LE; Santos, ES | 1 |
| Kay, LE; Ruschak, AM; Schimmer, AD; Slassi, M | 1 |
| Bollard, CM; Buglio, D; Derenzini, E; Illés, A; Ji, Y; Jóna, A; Khaskhely, N; Medeiros, LJ; Shafer, JA; Younes, A | 1 |
| Antilla, JC; He, Y; Li, G; Li, Z; Liang, X; Lin, M | 1 |
| Kale, AJ; Lechner, A; McGlinchey, RP; Moore, BS | 1 |
| Gu, H; Hu, S; Jin, X; Li, X; Yin, H; Yuan, B; Zhang, B; Zhu, J | 1 |
| Bhome, R; Penn, H | 1 |
| Barrière, J; Janus, N; Launay-Vacher, V; Thariat, J | 1 |
| Baumann, P; Junghanns, C; Mandl-Weber, S; Oduncu, F; Schmidmaier, R; Strobl, S | 1 |
| Kang, SG; Kim, SG; Lee, WH; Lee, YH; Lee, YS | 1 |
| Nogueira, JM; Portugal, FC; Rodrigues, C | 1 |
| Gallastegui, N; Groll, M | 1 |
| Scheen, AJ | 1 |
| Bergadà, L; Dolcet, X; Llombart-Cussac, A; Martí, RM; Matias-Guiu, X; Sorolla, A; Valls, J; Yeramian, A | 1 |
| Hervera, A; Leánez, S; Motterlini, R; Negrete, R; Pol, O | 1 |
| Kumara Swamy, KC; Sajna, KV | 1 |
| Ghosh, AC; Schulzke, C; Zubair, M | 1 |
| Alam, M; Barnett, JW; Berry, P; Browner, MF; Frank, K; Frauchiger, S; Harris, S; He, Y; Hekmat-Nejad, M; Hendricks, T; Henningsen, R; Hermann, JC; Hilgenkamp, R; Ho, H; Hoffman, A; Hsu, PY; Hu, DQ; Itano, A; Jahangir, A; Jaime-Figueroa, S; Jin, S; Kuglstatter, A; Kutach, AK; Liao, C; Lynch, S; Menke, J; Niu, L; Patel, V; Railkar, A; Roy, D; Shao, A; Shaw, D; Soth, M; Steiner, S; Sun, Y; Tan, SL; Vu, MD; Wang, S; Yee, C | 1 |
| Edmunds, J; Ericsson, A; Fiamengo, B; Frank, K; Friedman, M; George, D; George, J; Goedken, E; Kotecki, B; Martinez, G; Merta, P; Morytko, M; Shekhar, S; Skinner, B; Stewart, K; Van Epps, S; Voss, J; Wallace, G; Wang, L; Wishart, N | 1 |
| Akintayo, A; Chen, Z; El-Rayes, B; Fanucchi, MP; Harvey, RD; Kauh, JS; Khuri, FR; Lewis, CM; Nadella, P; Owonikoko, TK; Ramalingam, SS; Rogatko, A; Shin, DM; Tighiouart, M | 1 |
| Bhagirath, N; Chen, S; Chiao, E; Goldstein, DM; Hermann, JC; Hsu, J; Kennedy-Smith, JJ; Kuglstatter, A; Liao, C; Liu, W; Lowrie, LE; Lucas, MC; Luk, KC; Lynch, SM; Menke, J; Niu, L; O-Yang, C; Owens, TD; Padilla, F; Railkar, A; Schoenfeld, RC; Slade, M; Steiner, S; Tan, YC; Villaseñor, AG; Wang, C; Wanner, J; Xie, W; Xu, D; Zhang, X; Zhou, M | 1 |
| Aquilante, CL; Kosmiski, LA; Predhomme, JA; Sidhom, MS; Wempe, MF | 1 |
| Abe, M; Fujii, S | 1 |
| Hu, Y; Wu, P; Zhang, J | 1 |
| Andriamanana, I; Duretz, B; Gana, I; Hulin, A | 1 |
| Christensen, JG; Ishiguro-Oonuma, T; McDonald, DM; Schriver, BJ; Sennino, B | 1 |
| Kiefl, J; Schieberle, P | 1 |
| Li, P; Lin, M; Liu, X; Song, H; Xu, Q; Yao, J | 1 |
| Aoyama, K; Asano, M; Dougan, DR; Hamada, T; Hashimoto, K; Ishikawa, T; Mol, CD; Morishita, N; Saito, B; Shiokawa, Z; Sumi, H; Yabuki, M; Yoshida, S; Yoshimatsu, M | 1 |
| Lasekan, O | 1 |
| Dawidowski, M; Kubica, K; Skolmowski, M; Turło, J; Wilczek, M | 1 |
| Gao, X; Jin, Z; Lu, J; Yan, S; Yang, B | 1 |
| Berger, M; Ford, P; Goy, A; Hernandez-Ilzaliturri, FJ; Kahl, B; Protomastro, E | 1 |
| Anderl, JL; Assaraf, YG; Cloos, J; Jansen, G; Kale, AJ; Kaspers, GJ; Moore, BS; Niewerth, D; Riethoff, LF; van Meerloo, J; Zweegman, S | 1 |
| Himori, N; Maruyama, K; Nakazawa, T; Omodaka, K; Ryu, M; Shiga, Y; Tanaka, Y; Yamamoto, K; Yasuda, M | 1 |
| Huang, WX; Shi, L; Yu, CB; Zhou, YG | 1 |
| Chen, S; Dai, Y; Grant, S; Jones, R; Leng, Y; Lin, H; Orlowski, RZ; Pei, XY; Zhang, Y; Zhou, L | 1 |
| Chońska, J; Dawidowski, M; Mika, W; Turło, J | 1 |
| Barraja, P; Carbone, A; Cirrincione, G; Diana, P; Montalbano, A; Parrino, B; Spanò, V | 1 |
| Bartlett, M; de Vicente, J; Hekmat-Nejad, M; Henningsen, R; Hermann, JC; Jin, S; Kuglstatter, A; Lemoine, R; Li, H; Lovey, AJ; Menke, J; Niu, L; Patel, V; Petersen, A; Setti, L; Shao, A; Soth, M; Tivitmahaisoon, P; Vu, MD | 1 |
| Irschik, H; Jansen, R; Kunze, B; Mohr, KI; Müller, R; Sood, S; Stadler, M | 1 |
| Chandra, J; Corrales-Medina, FF; Manton, CA; Orlowski, RZ | 1 |
| Adam, A; Barry, ER; Beran, G; Cairo, S; Clark, EA; D'Cruz, CM; Déas, O; Fawell, SE; Frigault, MM; Hattersley, M; Henry, RE; Jones, RD; Linsenmayer, D; Nicolle, D; Reimer, C; Schuller, AG; Smith, A; Wilson, J; Zinda, M | 1 |
| Balci, M; Basceken, S | 1 |
| Blaney, J; Burdick, DJ; Chen, H; Drummond, J; Goeser, L; Heise, C; Magnuson, S; Moffat, J; Pan, B; Wang, S; Wang, W; Yin, J | 1 |
| Allmann, TC; Jones, PG; Lindel, T; Moldovan, RP | 1 |
| Chen, SB; Gu, LQ; Huang, SL; Huang, ZS; Li, D; Li, PH; Mai, YW; Ou, TM; Tan, JH; Yao, PF; Zeng, P | 1 |
| Carcolé, M; Castany, S; Leánez, S; Pol, O | 1 |
| Krishna, R; Lakshmi, P; Lalitha, P; Sakthivel, N; Veena, V; Vidhyapriya, P | 1 |
| Boos, A; Chen, B; Fairhurst, RA; Furet, P; Guagnano, V; Jeay, S; Jiang, S; Lu, W; Marsilje, TH; McCarthy, C; Michellys, PY; Niklaus, M; Schnell, C; Stauffer, F; Stutz, S; Vaupel, A | 1 |
| Bujalska-Zadrożny, M; Dawidowski, M; de Cordé, A; Kleczkowska, P; Kogut, E | 1 |
| Atsumi, T; Ishizu, A; Kusunoki, Y; Miyoshi, A; Miyoshi, H; Nakamura, A; Nakazawa, D; Shida, H; Tomaru, U; Yamada, M | 1 |
| Chen, WC; Chen, YH; Lee, JC; Lin, CK; Tseng, CK; Wu, YH; Young, KC | 1 |
| Amin, HM; Benjamin, RS; Buford, AS; Daw, NC; Fokt, I; Lamhamedi-Cherradi, SE; Lazar, AJ; Ludwig, JA; Maywald, RL; Menegaz, BA; Mikos, AG; Naing, A; Priebe, W; Ramamoorthy, V; Ratan, R; Rohren, EM; Skora, S; Subbiah, V; Vishwamitra, D; Wang, J; Wang, Y | 1 |
| Bi, X; Sun, G; Zhang, L | 1 |
| Duan, H; Li, N; Liu, H; Pu, F; Xiao, S; Zhang, A; Zhang, G; Zhao, L; Zhou, EM | 1 |
| Liu, C; Wu, S; Xiao, R; Zhang, H | 1 |
| Morimoto-Kamata, R; Yui, S | 1 |
| Biasioli, F; Cappellin, L; Lazazzara, V; Perazzolli, M; Pertot, I; Puopolo, G | 1 |
| Hallur, G; Mullangi, R; Saini, NK; Sulochana, SP; Tamizharasan, N; Zainuddin, M | 1 |
| Leánez, S; Pol, O; Redondo, A; Riego, G | 1 |
| Carella, N; Carr, BI; Cavallini, A; D'Alessandro, R; Lippolis, C; Messa, C; Refolo, MG | 1 |
| Green, AP; Turner, NJ; Xu, J | 1 |
| Adlin Jenifer, JSC; Citarasu, T; Eswaramoorthy Thirumalaikumar, CL; Jeraldin Nisha, SR; Michaelbabu, M; Uma, G | 1 |
| Abotsi, EE; Afoakwa, EO; De Cooman, L; De Winne, A; Dewettinck, K; Hinneh, M; Messens, K; Simonis, J; Tzompa-Sosa, DA; Van de Walle, D; Van Durme, J | 1 |
| Abraham, NG; Boumaza, I; Faroqui, M; Peterson, SJ; Raza, A; Rubinstein, R; Stec, D; Zhang, Y | 1 |
| Adamia, S; Buhrlage, SJ; Case, AE; Dubreuil, P; Gokhale, PC; Gray, N; Griffin, JD; Letard, S; Liu, X; Meng, C; Sattler, M; Stone, RM; Tiv, HL; Wang, J; Weisberg, E; Yang, J | 1 |
| Altamirano-Lagos, MJ; Fernández-Fierro, A; Funes, SC; Gómez-Santander, F; Jara, EL; Kalergis, AM; Mackern-Oberti, JP; Pulgar-Sepúlveda, R; Rebolledo-Zelada, D; Ríos, M; Rivera-Perez, D; Roa, JC; Villarroel, A | 1 |
| Kim, I; Lee, JH; Namkung, W; Park, SH; Seo, Y | 1 |
| Ikeda, Y; Ikeuchi, M; Nakayama, Y; Saito, Y; Yamagishi, A; Yuki, R | 1 |
| Martin-Loeches, I; O'Sullivan, S; Rodriguez, A; Torres, A | 1 |
| Takashita, E | 1 |
| Cassidy, K; Katyayan, K; Monk, S; Yi, P | 1 |
| Fuchikami, C; Honda, Y; Kosugi, K; Kuramoto, K; Kuwano, K; Numakura, Y | 1 |
| Arosio, M; Catalano, R; Elli, FM; Giardino, E; Luconi, M; Mangili, F; Mannelli, M; Mantovani, G; Morelli, V; Peverelli, E; Serban, AL; Spada, A; Treppiedi, D | 1 |
| Benz, J; Ehler, A; Guba, W; Hofmann, EC; Huber, S; Hug, M; Jagasia, R; Rodríguez Sarmiento, RM; Rufer, AC; Topp, A | 1 |
| Arantes, ALF; Cazuza, RA; Leite-Panissi, CRA; Pol, O | 1 |
| Bösl, M; Dunkel, A; Hofmann, TF | 1 |
| Brügel, M; Habler, K; Liebchen, U; Paal, M; Scharf, C; Schönermarck, U; Teupser, D; Vogeser, M | 1 |
| Aluise, CD; Baker, TK; Beck, JP; Boggs, LN; Borders, AR; Brier, RA; Cocke, PJ; Erickson, JA; Garcia-Losada, P; Green, SJ; Hembre, EJ; Hendle, J; Lopez, JE; Lowe, SL; Mathes, BM; May, PC; McKinzie, DL; Mergott, DJ; Monk, SA; Porter, WJ; Stout, SL; Timm, DE; Watson, BM; Willis, BA; Winneroski, LL; Yang, Z | 1 |
| Chang, J; Chen, KX; Chen, LF; Fan, ZS; Guo, H; Jiang, HL; Liu, YD; Lu, CH; Luo, XM; Song, J; Yang, RR; Zhang, KK; Zhang, SL; Zhang, YH; Zheng, MY; Zhou, GZ; Zhou, JY | 1 |
| Andrade-Pavón, D; Barrera, E; Delgado, F; Escalante, CH; Gómez-García, O; Miranda-Sánchez, D; Tamariz, J; Villa-Tanaca, L | 1 |
18 review(s) available for pyrroles and pyrazines
| Article | Year |
|---|---|
Mitigating heterocycle metabolism in drug discovery.
Topics: Animals; Biotransformation; Databases, Factual; Drug Discovery; Drug Interactions; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds, 4 or More Rings; Humans; Mice; Pharmaceutical Preparations; Rats | 2012 |
[Nitrogen compounds of tobacco smoke].
Topics: Acridines; Alkaloids; Alkanes; Amines; Amino Acids; Aniline Compounds; Carbazoles; Cyanates; Indoles; Isoquinolines; Ketones; Niacinamide; Nicotiana; Nicotine; Nicotinic Acids; Nitriles; Nitrites; Nitrosamines; Piperidines; Plants, Toxic; Pyrazines; Pyridines; Pyrroles; Pyrrolidines; Quinolines; Quinoxalines; Smoking | 1969 |
Mycotoxin photosensitivity.
Topics: Animal Feed; Animals; Cattle; Cattle Diseases; Chemical and Drug Induced Liver Injury; Cholestasis; Eczema; Indoles; Liver Diseases; Medicago sativa; Mitosporic Fungi; Mycotoxins; Photosensitivity Disorders; Pyrazines; Pyrroles; Sheep; Sheep Diseases; United States | 1973 |
New drugs in acute myeloid leukemia.
Topics: Acute Disease; Adenine Nucleotides; Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antimetabolites, Antineoplastic; Antineoplastic Agents; Arabinonucleosides; Azacitidine; Bevacizumab; Boronic Acids; Bortezomib; Clofarabine; Cytosine; Decitabine; Dioxolanes; Humans; Indoles; Leukemia, Myeloid; Phthalazines; Pyrazines; Pyridines; Pyrroles; Thionucleotides | 2002 |
New therapeutic strategies for soft tissue sarcomas.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Clinical Trials as Topic; Dioxoles; Docetaxel; Epothilones; Guanidines; Humans; Indoles; Isoquinolines; Protein Kinase Inhibitors; Protein Kinases; Pyrazines; Pyrroles; Sarcoma; Sirolimus; Sunitinib; Taxoids; Tetrahydroisoquinolines; TOR Serine-Threonine Kinases; Trabectedin | 2003 |
[Current screening for molecular target therapy of cancer].
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Benzamides; Boronic Acids; Bortezomib; Drug Delivery Systems; Drug Screening Assays, Antitumor; Gefitinib; Heat-Shock Proteins; Humans; Imatinib Mesylate; Indoles; Lactones; Mice; Neoplasms; Phthalazines; Piperazines; Piperidines; Pyrazines; Pyridines; Pyrimidines; Pyrroles; Quinazolines; Sunitinib | 2003 |
Targeting ubiquitin in cancers.
Topics: Antineoplastic Agents; Boronic Acids; Bortezomib; Cell Communication; Cell Cycle; Genetic Therapy; Heat-Shock Proteins; Humans; Lactones; Neoplasms; Pyrazines; Pyrroles; Ubiquitin | 2006 |
Antiproliferative and proapoptotic effects of proteasome inhibitors and their combination with histone deacetylase inhibitors on leukemia cells.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Boronic Acids; Bortezomib; Cell Line, Tumor; Cell Proliferation; Drug Synergism; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Humans; Lactones; Leukemia; Oligopeptides; Protease Inhibitors; Pyrazines; Pyrroles | 2009 |
Targeting the proteasome pathway.
Topics: Acetylcysteine; Animals; Antineoplastic Agents; Biological Products; Boronic Acids; Bortezomib; Drug Delivery Systems; Drug Discovery; Humans; Lactones; Neoplasms; Peptides; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Pyrroles; Structure-Activity Relationship; Ubiquitin; Ubiquitin-Activating Enzymes; Ubiquitins | 2009 |
Neurological adverse effects caused by cytotoxic and targeted therapies.
Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Benzamides; Bevacizumab; Boronic Acids; Bortezomib; Clinical Trials as Topic; Dacarbazine; Drug Approval; Epothilones; Humans; Imatinib Mesylate; Indoles; Neoplasms; Neurotoxicity Syndromes; Organoplatinum Compounds; Oxaliplatin; Piperazines; Pyrazines; Pyrimidines; Pyrroles; Sunitinib; Temozolomide; Tubulin Modulators; United States; United States Food and Drug Administration | 2009 |
Proteasome inhibitors in the treatment of multiple myeloma.
Topics: Antineoplastic Agents; Boronic Acids; Bortezomib; Humans; Lactones; Multiple Myeloma; Oligopeptides; Protease Inhibitors; Pyrazines; Pyrroles | 2009 |
Therapy of relapsed and refractory multiple myeloma.
Topics: Adrenal Cortex Hormones; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Dexamethasone; Hematopoietic Stem Cell Transplantation; Humans; Lactones; Lenalidomide; Middle Aged; Multiple Myeloma; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Pyrroles; Secondary Prevention; Thalidomide | 2011 |
Novel molecular targeted therapies for refractory thyroid cancer.
Topics: Angiogenesis Inhibitors; Anilides; Antineoplastic Agents; Axitinib; Benzamides; Benzenesulfonates; Benzoquinones; Bibenzyls; Boronic Acids; Bortezomib; Depsipeptides; ErbB Receptors; Gefitinib; Histone Deacetylase Inhibitors; HSP90 Heat-Shock Proteins; Humans; Hydroxamic Acids; Imatinib Mesylate; Imidazoles; Indazoles; Indoles; Lactams, Macrocyclic; Lenalidomide; Niacinamide; Oligonucleotides; Phenylurea Compounds; Piperazines; Piperidines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-kit; Pyrazines; Pyridines; Pyrimidines; Pyrroles; Quinazolines; Quinolines; Receptor Protein-Tyrosine Kinases; Receptors, Vascular Endothelial Growth Factor; Sorafenib; Sulfonamides; Sunitinib; Thalidomide; Thyroid Neoplasms; Valproic Acid; Vorinostat | 2012 |
Novel proteasome inhibitors to overcome bortezomib resistance.
Topics: Allosteric Site; Animals; Antineoplastic Agents; Apoptosis; Boronic Acids; Bortezomib; Cell Line, Tumor; Chloroquine; Clioquinol; Drug Resistance, Neoplasm; Humans; Hydroxyquinolines; Lactones; Neoplasms; Oligopeptides; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Pyrroles; Threonine; Ubiquitinated Proteins; Ubiquitination | 2011 |
Pharmacokinetic evaluation of atorvastatin and sitagliptin in combination for the treatment of type 2 diabetes.
Topics: Atorvastatin; Blood Glucose; Cardiovascular Diseases; Cholesterol; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Drug Combinations; Drug Interactions; Drug Therapy, Combination; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Pyrazines; Pyrroles; Risk Assessment; Sitagliptin Phosphate; Treatment Outcome; Triazoles | 2012 |
Clinical and marketed proteasome inhibitors for cancer treatment.
Topics: Boron Compounds; Boronic Acids; Bortezomib; Glycine; Humans; Lactones; Neoplasms; Oligopeptides; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Pyrroles; Structure-Activity Relationship; Threonine | 2013 |
Influenza management with new therapies.
Topics: Adrenal Cortex Hormones; Amides; Antiviral Agents; Critical Care; Critical Illness; Dibenzothiepins; Enzyme Inhibitors; Humans; Influenza, Human; Morpholines; Neuraminidase; Oseltamivir; Pyrazines; Pyridines; Pyridones; Pyrimidines; Pyrroles; Respiration, Artificial; Triazines; Zanamivir | 2020 |
Influenza Polymerase Inhibitors: Mechanisms of Action and Resistance.
Topics: Amides; Antiviral Agents; Dibenzothiepins; Drug Resistance, Viral; Humans; Influenza, Human; Morpholines; Orthomyxoviridae; Pyrazines; Pyridines; Pyridones; Pyrimidines; Pyrroles; RNA-Dependent RNA Polymerase; Triazines; Virus Replication | 2021 |
5 trial(s) available for pyrroles and pyrazines
| Article | Year |
|---|---|
[Effects of atorvastatin and acipimox on the lipid spectrum of blood plasma, endothelial function and a clinical course of unstable angina pectoris].
Topics: Angina, Unstable; Atorvastatin; Brachial Artery; Cholesterol, LDL; Drug Therapy, Combination; Endothelium, Vascular; Follow-Up Studies; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Male; Pyrazines; Pyrroles; Treatment Outcome; Vasodilation | 2006 |
A phase 1 Bayesian dose selection study of bortezomib and sunitinib in patients with refractory solid tumor malignancies.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bayes Theorem; Boronic Acids; Bortezomib; Drug Administration Schedule; Female; Humans; Indoles; Male; Maximum Tolerated Dose; Middle Aged; Neoplasms; Pyrazines; Pyrroles; Sunitinib; Thyroid Neoplasms | 2013 |
Effect of ABCB1 polymorphisms and atorvastatin on sitagliptin pharmacokinetics in healthy volunteers.
Topics: Adult; Atorvastatin; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biotransformation; Cohort Studies; Colorado; Cross-Over Studies; Dipeptidyl-Peptidase IV Inhibitors; Drug Interactions; Female; Genetic Association Studies; Half-Life; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Metabolic Clearance Rate; Middle Aged; Polymorphism, Single Nucleotide; Pyrazines; Pyrroles; Sitagliptin Phosphate; Triazoles; Young Adult | 2013 |
A phase I/II study of the pan Bcl-2 inhibitor obatoclax mesylate plus bortezomib for relapsed or refractory mantle cell lymphoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Combined Modality Therapy; Disease Progression; Female; Humans; Indoles; Lymphoma, Mantle-Cell; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Pyrroles; Treatment Outcome | 2014 |
Excretion, Mass Balance, and Metabolism of [
Topics: Administration, Oral; Adult; Aldehyde Oxidase; Animals; Carbon Radioisotopes; Gastrointestinal Microbiome; Healthy Volunteers; Heterocyclic Compounds, 2-Ring; Humans; Intestinal Elimination; Intestinal Mucosa; Intestinal Reabsorption; Male; Middle Aged; Models, Animal; Oxidation-Reduction; Pyrazines; Pyrroles; Radiometry; Rats; Sulfenic Acids | 2020 |
148 other study(ies) available for pyrroles and pyrazines
| Article | Year |
|---|---|
Highly selective inhibitors of thromboxane synthetase. 2. Pyridine derivatives.
Topics: Animals; Oxidoreductases; Pyridines; Sheep; Structure-Activity Relationship; Thromboxane-A Synthase | 1981 |
[A study of the effect of SC 26 348 on sinus function and atrioventricular conduction (author's transl)].
Topics: Adult; Aged; Anti-Arrhythmia Agents; Atrioventricular Node; Cardiac Pacing, Artificial; Drug Evaluation; Female; Heart Conduction System; Humans; Injections, Intravenous; Male; Middle Aged; Pyrazines; Pyrroles; Sinoatrial Node; Time Factors | 1977 |
The stimulus-secretion coupling of glucose-induced insulin release-XVII. Effects of sulfonylureas and diazoxide on insular biosynthetic activity.
Topics: Animals; Cyclohexanes; Cyclopentanes; Diazoxide; Glucose; Hormones; In Vitro Techniques; Insulin; Islets of Langerhans; Leucine; Oxidation-Reduction; Peptide Biosynthesis; Proinsulin; Pyrazines; Pyrroles; Rats; Sulfonylurea Compounds; Tolbutamide | 1975 |
[Pyrazino(1,2-a)- and 1,4-diazepino(1,2-a)- indoles. III. Synthesis of pyrrolo(2',1':3,4)pyrazino(1,2-a)indoles and pyrrolo(2',1':3,4)-1,4-diazepino(1,2-a) indoles; isoindolo(2',1':3,4)pyrazino(1,2-a)-indoles and isoindolo(2',1':3,4)-1,4-diazepino(1,2-a)i
Topics: Azepines; Carbazoles; Indoles; Pyrazines; Pyrroles | 1975 |
[Syntheses of radioactive cyclols as potential precursors of the peptide moiety of ergot alkaloids].
Topics: Acylation; Carbon Radioisotopes; Chromatography, Thin Layer; Cyclization; Ergot Alkaloids; Ergotamine; Mass Spectrometry; Oxazoles; Peptides; Pyrazines; Pyrroles | 1975 |
Activity of gamma-glutamyl transpeptidase and other enzymes in the serum of sheep with liver or kidney damage.
Topics: Alcohol Oxidoreductases; Animals; Arginase; Aspartate Aminotransferases; Bilirubin; Brain; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Female; gamma-Glutamyltransferase; Glutamate Dehydrogenase; Indoles; Intestine, Small; Kidney; Kidney Diseases; Ligation; Liver; Liver Diseases; Male; Mercury Poisoning; Muscles; Mycotoxins; Myocardium; Pancreas; Pyrazines; Pyrroles; Sheep; Sheep Diseases; Urea | 1974 |
Studies on bile secretion with the aid of the isolated perfused rat liver. I. Inhibitory action of sporidesmin and icterogenin.
Topics: Animals; Bile; Bile Ducts, Intrahepatic; Carboxylic Acids; Cholestasis; Female; Indoles; Liver; Mycotoxins; Oleanolic Acid; Perfusion; Pyrazines; Pyrroles; Rats; Secretory Rate; Triterpenes | 1974 |
Effects of the mycotoxin sporidesmin on swelling and respiration of liver mitochondria.
Topics: Adenosine Triphosphate; Animals; Chlorides; Electron Transport; Guinea Pigs; Haplorhini; In Vitro Techniques; Indoles; Magnesium; Mitochondria, Liver; Mitochondrial Swelling; Mycotoxins; Oxygen Consumption; Phosphates; Potassium Chloride; Pyrazines; Pyrroles; Quaternary Ammonium Compounds; Rabbits; Rats; Sheep; Species Specificity; Succinates; Sucrose; Time Factors; Ultraviolet Rays | 1974 |
The involvement of the disulphide group of sporidesmin in the action of the toxin on swelling and respiration of liver mitochondria.
Topics: Alkaloids; Animals; Anti-Bacterial Agents; Chemical Phenomena; Chemistry; Chromatography; Disulfides; Dithiothreitol; Edetic Acid; Guinea Pigs; In Vitro Techniques; Indoles; Magnesium; Membranes; Mitochondria, Liver; Mitochondrial Swelling; Mycotoxins; Oxygen Consumption; Piperazines; Pyrazines; Pyrroles; Rabbits; Rats; Sheep; Sulfur Radioisotopes; Toxins, Biological; Ultraviolet Rays | 1974 |
Studies on the volatile components of peated malt. III. Identification of acidic and basic components.
Topics: Benzoates; Chromatography, Gas; Cinnamates; Edible Grain; Fatty Acids; Mass Spectrometry; Phenylacetates; Pyrazines; Pyrroles; Soil | 1974 |
A total synthesis of sporidesmin A.
Topics: Indoles; Mycotoxins; Pyrazines; Pyrroles; Stereoisomerism | 1973 |
Radiation chemistry of nitrogen and sulfur heterocyclics.
Topics: Chromatography, Gas; Free Radicals; Heterocyclic Compounds; Imidazoles; Nitrogen; Pyrazines; Pyrazoles; Pyrimidines; Pyrroles; Radiochemistry; Sulfur; Tetrazoles; Thiazoles; Thiophenes; Triazines; Triazoles | 1973 |
Recovery of sporidesmin from side fractions.
Topics: Anti-Bacterial Agents; Chromatography; Chromatography, Paper; Crystallization; Indoles; Mitosporic Fungi; Pyrazines; Pyrroles; Solubility | 1973 |
Tracheal organ cultures for the bioassay of nanogram quantities of mycotoxins.
Topics: Aflatoxins; Alkaloids; Animals; Biological Assay; Chickens; Ducks; Furans; Indoles; Ketones; Lethal Dose 50; Microchemistry; Mycotoxins; Ochratoxins; Organ Culture Techniques; Pyrans; Pyrazines; Pyrroles; Trachea; Xanthenes | 1972 |
Changes in serum triglyceride and cholesterol levels independently of free fatty acid after lipolysis inhibitors.
Topics: Animals; Carbon Isotopes; Carboxylic Acids; Cholesterol; Chromatography, Thin Layer; Diet; Esters; Fasting; Fatty Acids, Nonesterified; Fructose; Lipids; Liver; Male; Metabolism; Nicotinic Acids; Palmitic Acids; Phospholipids; Pyrazines; Pyrazoles; Pyrroles; Quinolines; Rats; Time Factors; Triglycerides | 1970 |
Salicylate hypoglycemic action in alloxan-diabetic rats and structural relationships.
Topics: Animals; Benzene Derivatives; Blood Glucose; Diabetes Mellitus, Experimental; Female; Heterocyclic Compounds; Male; Mass Screening; Nicotinic Acids; Pyrazines; Pyridinium Compounds; Pyrimidines; Pyrroles; Rats; Salicylates; Thiophenes | 1968 |
Tetrahydropyrrolo[1,2-a]quinoxalines and tetrahydropyrrolo[1,2-a]pyrido[3,2-a]pyrazines: vascular smooth muscle relaxants and antihypertensive agents.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Chemical Phenomena; Chemistry; Female; Indicators and Reagents; Magnetic Resonance Spectroscopy; Mass Spectrometry; Muscle Relaxation; Muscle, Smooth, Vascular; Neuromuscular Depolarizing Agents; Optical Rotation; Pyrazines; Pyrroles; Quinoxalines; Rabbits; Spectrophotometry, Infrared; Structure-Activity Relationship | 1984 |
[Substances with central nervous system activity. Derivatives of octahydro-1,4-dihydroxypyrrolo(1,2-a)pyrazine-6-carboxylic acids].
Topics: Aggression; Animals; Anticonvulsants; Behavior, Animal; Central Nervous System; Chemical Phenomena; Chemistry; Humans; Hypnotics and Sedatives; Lethal Dose 50; Mice; Motor Activity; Pyrazines; Pyrroles; Rats | 1984 |
Inhibitory effect of Distamycin-A and a pyrazino-pyrazine derivative on tomato spotted wilt virus.
Topics: Antiviral Agents; Distamycins; Nicotiana; Plant Viruses; Plants, Toxic; Pyrazines; Pyrroles; Time Factors; Virus Replication | 1983 |
Genotoxicity of 1,3-dithiane and 1,4-dithiane in the CHO/SCE assay and the Salmonella/microsomal test.
Topics: Animals; Biotransformation; CHO Cells; Cricetinae; Furans; Heterocyclic Compounds; Imidazoles; Maillard Reaction; Mutagenicity Tests; Mutagens; Pyrazines; Pyridines; Pyrroles; Salmonella typhimurium; Sister Chromatid Exchange; Sulfur Compounds; Thiazoles; Thiophenes | 1994 |
Effects of SCA40 on human bronchi and on guinea pig main bronchi in vitro. Comparison with cromakalim.
Topics: Acetylcholine; Animals; Benzopyrans; Bronchi; Bronchodilator Agents; Capsaicin; Charybdotoxin; Cromakalim; Electric Stimulation; Female; Glyburide; Guinea Pigs; Humans; Imidazoles; In Vitro Techniques; Isoproterenol; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Neurokinin A; Nitroprusside; Osmolar Concentration; Parasympatholytics; Potassium Channel Blockers; Potassium Channels; Pyrazines; Pyrroles; Tetraethylammonium; Tetraethylammonium Compounds | 1996 |
Effects of SCA40 on human isolated bronchus and human polymorphonuclear leukocytes: comparison with rolipram, SKF94120 and levcromakalim.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Anti-Inflammatory Agents, Non-Steroidal; Benzopyrans; Bronchi; Bronchodilator Agents; Calcium; Cardiotonic Agents; Cromakalim; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclic Nucleotide Phosphodiesterases, Type 5; Humans; Imidazoles; In Vitro Techniques; Leukocyte Elastase; Leukotriene B4; Muscle Relaxation; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphoric Diester Hydrolases; Pyrazines; Pyrroles; Pyrrolidinones; Rolipram; Superoxides | 1996 |
Evidence against a cytochrome P450-derived reactive oxygen species as the mediator of the nitric oxide-independent vasodilator effect of bradykinin in the perfused heart of the rat.
Topics: Animals; Arachidonic Acid; Benzimidazoles; Benzopyrans; Bradykinin; Cromakalim; Cyclic N-Oxides; Cytochrome P-450 Enzyme System; Free Radical Scavengers; Heart; Hydrogen Peroxide; Imidazoles; In Vitro Techniques; Indomethacin; Kidney Cortex; Luminescent Measurements; Male; Microsomes; Nitric Oxide; Nitroarginine; Parasympatholytics; Perfusion; Pyrazines; Pyrroles; Rats; Rats, Wistar; Reactive Oxygen Species; Superoxides; Vasodilator Agents | 1997 |
TRH mimetics: differentiation of antiamnesic potency from antidepressant effect.
Topics: Amino Acid Sequence; Amnesia; Animals; Antidepressive Agents; Azocines; Electroencephalography; Hypoxia; Magnetic Resonance Spectroscopy; Mice; Molecular Sequence Data; Protein Conformation; Pyrazines; Pyrroles; Rats; Thyrotropin-Releasing Hormone | 1997 |
Selective dopamine D4 receptor antagonists reverse apomorphine-induced blockade of prepulse inhibition.
Topics: Animals; Apomorphine; Cell Line; Dopamine Antagonists; Humans; Male; Piperazines; Pyrazines; Pyridines; Pyrimidines; Pyrroles; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, Dopamine D4; Reflex, Startle; Sulfonamides | 1998 |
Effect of high hydrostatic pressure on the volatile components of a glucose-lysine model system.
Topics: Furans; Glucose; Hydrostatic Pressure; Ketones; Lysine; Models, Chemical; Pyrans; Pyrazines; Pyridines; Pyrroles; Volatilization | 1999 |
Topographically based search for an "Ethogram" among a series of novel D(4) dopamine receptor agonists and antagonists.
Topics: Animals; Behavior, Animal; Brain; Brain Mapping; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Habituation, Psychophysiologic; Male; Psychotic Disorders; Pyrazines; Pyridines; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Dopamine D4 | 2000 |
Optimizing headspace temperature and time sampling for identification of volatile compounds in ground roasted Arabica coffee.
Topics: Alcohols; Aldehydes; Coffee; Esters; Food Handling; Furans; Gas Chromatography-Mass Spectrometry; Ketones; Odorants; Pyrazines; Pyrroles; Temperature; Thermodynamics | 2001 |
Thermal degradation studies of glucose/glycine melanoidins.
Topics: Furans; Gas Chromatography-Mass Spectrometry; Glucose; Glycine; Hot Temperature; Molecular Weight; Polymers; Pyrazines; Pyrroles; Volatilization | 2002 |
Antioxidative activity of heterocyclic compounds found in coffee volatiles produced by Maillard reaction.
Topics: Aldehydes; Antioxidants; Coffee; Furans; Heterocyclic Compounds; Maillard Reaction; Pyrazines; Pyrroles; Thiazoles; Thiophenes; Volatilization | 2002 |
[Perspectives on the oncologist pharmacopoeia].
Topics: Angiogenesis Inhibitors; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Boronic Acids; Bortezomib; Dioxoles; Indoles; Isoquinolines; Neoplasms; Organoplatinum Compounds; Protease Inhibitors; Pyrazines; Pyrroles; Quinazolines; Sesquiterpenes; Tetrahydroisoquinolines; Trabectedin | 2003 |
[RADIOPROTECTIVE ACTION OF NITROGENOUS HETEROCYCLIC COMPOUNDS].
Topics: Animals; Benzimidazoles; Heterocyclic Compounds; Imidazoles; Mice; Pharmacology; Piperazines; Purines; Pyrazines; Pyrazoles; Pyridazines; Pyridines; Pyrimidines; Pyrroles; Radiation Injuries; Radiation Injuries, Experimental; Research; Triazoles | 1964 |
Pyrazine analogues of dipyrrolylquinoxalines.
Topics: Crystallography, X-Ray; Heterocyclic Compounds, 3-Ring; Heterocyclic Compounds, 4 or More Rings; Molecular Conformation; Molecular Structure; Pyrazines; Pyrroles; Quinoxalines | 2003 |
Phase 2 enzyme induction by the major metabolite of oltipraz.
Topics: Animals; Blotting, Western; Cell Death; DNA-Binding Proteins; Enzyme Induction; Glutathione; Glutathione Transferase; Heme Oxygenase (Decyclizing); Luciferases; Methylation; Mice; NAD(P)H Dehydrogenase (Quinone); NF-E2-Related Factor 2; Prodrugs; Pyrazines; Pyrroles; Thiones; Thiophenes; Time Factors; Trans-Activators; Transcription Factors; Transfection; Tumor Cells, Cultured | 2003 |
Cyclohexyl-octahydro-pyrrolo[1,2-a]pyrazine-based inhibitors of human N-myristoyltransferase-1.
Topics: Acyltransferases; Cell Division; Enzyme Inhibitors; Humans; Models, Molecular; Pyrazines; Pyrroles; Structure-Activity Relationship; Tumor Cells, Cultured | 2004 |
Chiroptical analysis of marine sponge alkaloids sharing the pyrrolopyrazinone core.
Topics: Alkaloids; Animals; Circular Dichroism; Molecular Structure; Porifera; Pyrazines; Pyrroles; Stereoisomerism | 2004 |
Synthesis, antimalarial activity, and molecular modeling of new pyrrolo[1,2-a]quinoxalines, bispyrrolo[1,2-a]quinoxalines, bispyrido[3,2-e]pyrrolo[1,2-a]pyrazines, and bispyrrolo[1,2-a]thieno[3,2-e]pyrazines.
Topics: Animals; Antimalarials; Cell Line; Crystallography, X-Ray; Drug Resistance; Erythrocytes; Hemeproteins; Humans; In Vitro Techniques; Models, Molecular; Plasmodium falciparum; Protein Binding; Pyrazines; Pyridines; Pyrroles; Quinoxalines; Rats; Structure-Activity Relationship | 2004 |
Pyrrolodiazines. 6. Palladium-catalyzed arylation, heteroarylation, and amination of 3,4-dihydropyrrolo[1,2-a]pyrazines.
Topics: Alkylation; Amination; Catalysis; Molecular Structure; Palladium; Pyrazines; Pyrroles | 2004 |
3D QSAR studies on GSK-3 inhibition by aloisines.
Topics: Binding Sites; CDC2-CDC28 Kinases; Cyclin-Dependent Kinase 2; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Pyrazines; Pyrroles; Quantitative Structure-Activity Relationship; Static Electricity | 2005 |
A macroglomerulus in the antennal lobe of leaf-cutting ant workers and its possible functional significance.
Topics: Animals; Ants; Electrophysiology; In Vitro Techniques; Olfactory Nerve; Olfactory Pathways; Organ Size; Pheromones; Plant Leaves; Pyrazines; Pyrroles; Sense Organs; Species Specificity | 2005 |
A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Apoptosis; Boronic Acids; Bortezomib; Caspases; Cell Movement; Cell Proliferation; Drug Synergism; Genes, bcl-2; Humans; Lactones; Lymphocytes; Mice; Mitochondria; Multiple Myeloma; NF-kappa B; Plasmacytoma; Protease Inhibitors; Proteasome Endopeptidase Complex; Pyrazines; Pyrroles; Tumor Cells, Cultured | 2005 |
From pyrroles to pyrrolo[1,2-a]pyrazinones: a new class of mGluR1 antagonists.
Topics: Animals; CHO Cells; Cricetinae; Inhibitory Concentration 50; Molecular Structure; Pyrazines; Pyrroles; Receptors, Metabotropic Glutamate; Structure-Activity Relationship | 2006 |
Synthesis and biological evaluation of novel hexahydro-pyrido[3',2':4,5]pyrrolo[1,2-a]pyrazines as potent and selective 5-HT(2C) receptor agonists.
Topics: Animals; CHO Cells; Cricetinae; Humans; Hydroxylation; Molecular Structure; Phospholipids; Pyrazines; Pyrroles; Receptor, Serotonin, 5-HT2C; Serotonin 5-HT2 Receptor Agonists; Structure-Activity Relationship | 2006 |
Chronic CO levels have [corrected] a beneficial effect on vascular relaxation in diabetes.
Topics: Acetylcholine; Animals; Aorta; Biliverdine; Blotting, Western; Carbon Monoxide; Chromium; Densitometry; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Endothelium, Vascular; Femoral Artery; Guanylate Cyclase; Heme; Immunohistochemistry; Male; Mesoporphyrins; Muscle Contraction; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Organometallic Compounds; Oxadiazoles; Oxidative Stress; Protoporphyrins; Pyrazines; Pyrroles; Quinoxalines; Rats; Rats, Sprague-Dawley; Stress, Mechanical; Time Factors | 2006 |
Does the donor-acceptor concept work for designing synthetic metals? III. Theoretical investigation of copolymers between quinoid acceptors and aromatic donors.
Topics: Metals; Models, Chemical; Models, Molecular; Molecular Conformation; Polymers; Pyrazines; Pyrroles; Quinoxalines; Thiadiazoles; Thiophenes | 2006 |
Identification of components responsible for the odor of cigar smoker's breath.
Topics: Breath Tests; Chromatography, Gas; Gas Chromatography-Mass Spectrometry; Humans; Mouth Mucosa; Nicotiana; Odorants; Pyrazines; Pyridines; Pyrroles; Saliva; Smell; Smoking; Specimen Handling; Tongue; Volatilization | 2006 |
Design of molecular wires based on supramolecular structures for application in glucose biosensors.
Topics: Biosensing Techniques; Ferric Compounds; Ferrocyanides; Glucose; Hydrogen Peroxide; Polymers; Pyrazines; Pyrroles | 2006 |
Different serotonin receptor agonists have distinct effects on sound-evoked responses in inferior colliculus.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acoustic Stimulation; Animals; Chiroptera; Dose-Response Relationship, Drug; Electrodes; Electrophysiology; Evoked Potentials, Auditory; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Inferior Colliculi; Iontophoresis; Male; Pyrazines; Pyridines; Pyrroles; Receptor, Serotonin, 5-HT1A; Serotonin; Serotonin Receptor Agonists | 2006 |
The proteasome inhibitor NPI-0052 is a more effective inducer of apoptosis than bortezomib in lymphocytes from patients with chronic lymphocytic leukemia.
Topics: Antineoplastic Agents; Apoptosis; Boronic Acids; Bortezomib; Humans; Lactones; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphocytes; Protease Inhibitors; Proteasome Inhibitors; Pyrazines; Pyrroles | 2006 |
NPI-0052 enhances tumoricidal response to conventional cancer therapy in a colon cancer model.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Boronic Acids; Bortezomib; Cell Cycle; Colonic Neoplasms; Drug Administration Routes; Drug Synergism; Female; Humans; Lactones; Mice; Mice, Nude; NF-kappa B; Proteasome Endopeptidase Complex; Pyrazines; Pyrroles; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Xenograft Model Antitumor Assays | 2006 |
Comparison of biochemical and biological effects of ML858 (salinosporamide A) and bortezomib.
Topics: Animals; Antineoplastic Agents; Binding, Competitive; Boronic Acids; Bortezomib; Drug Stability; Female; HeLa Cells; HT29 Cells; Humans; Lactones; Mice; Mice, Nude; Mice, SCID; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Pyrroles; Xenograft Model Antitumor Assays | 2006 |
The BH3-mimetic GX15-070 synergizes with bortezomib in mantle cell lymphoma by enhancing Noxa-mediated activation of Bak.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-X Protein; Boronic Acids; Bortezomib; Drug Synergism; Gene Expression Regulation, Neoplastic; Humans; Indoles; Lymphoma, Mantle-Cell; Molecular Mimicry; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Peptide Fragments; Protein Binding; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Pyrroles; Tumor Cells, Cultured | 2007 |
Combination of proteasome inhibitors bortezomib and NPI-0052 trigger in vivo synergistic cytotoxicity in multiple myeloma.
Topics: Animals; Boronic Acids; Bortezomib; Cell Line, Tumor; Cell Movement; Cell Survival; Endoplasmic Reticulum; Heat-Shock Proteins; Humans; Lactones; Mice; Multiple Myeloma; Neovascularization, Pathologic; NF-kappa B; Protease Inhibitors; Proteasome Endopeptidase Complex; Pyrazines; Pyrroles; Xenograft Model Antitumor Assays | 2008 |
A novel synthesis of arylpyrrolo[1,2-a]pyrazinone derivatives.
Topics: Animals; Cyclization; Drug Evaluation, Preclinical; Edema; Male; Mice; Pyrazines; Pyrroles | 2004 |
Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis.
Topics: Animals; Antineoplastic Agents; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; Boronic Acids; Bortezomib; Cell Line, Tumor; Cysteine Proteinase Inhibitors; Drug Resistance, Neoplasm; Humans; Indoles; Melanoma; Mice; Mitochondria; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Proteasome Inhibitors; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Pyrroles | 2007 |
Phenylethynyl-pyrrolo[1,2-a]pyrazine: a new potent and selective tool in the mGluR5 antagonists arena.
Topics: Dopamine Plasma Membrane Transport Proteins; Fluorescence; Humans; Molecular Structure; Norepinephrine Plasma Membrane Transport Proteins; Pyrazines; Pyrroles; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Structure-Activity Relationship | 2008 |
Dual targeting of the proteasome regulates survival and homing in Waldenstrom macroglobulinemia.
Topics: Boronic Acids; Bortezomib; Cell Adhesion; Cell Death; Cell Movement; Cells, Cultured; Drug Delivery Systems; Drug Synergism; Humans; Lactones; Proteasome Inhibitors; Pyrazines; Pyrroles; Waldenstrom Macroglobulinemia | 2008 |
Formation of pyrazines and a novel pyrrole in Maillard model systems of 1,3-dihydroxyacetone and 2-oxopropanal.
Topics: Dihydroxyacetone; Gas Chromatography-Mass Spectrometry; Maillard Reaction; Pyrazines; Pyrroles; Pyruvaldehyde; Taste; Volatilization | 2008 |
Synthesis of pyrido[2,3-e]pyrrolo[1,2-a]pyrazine derivatives via tandem iminium cyclization and smiles rearrangement.
Topics: Aldehydes; Catalysis; Cyclization; Imines; Molecular Structure; Pyrazines; Pyrroles | 2008 |
Inhibition of Yin Yang 1-dependent repressor activity of DR5 transcription and expression by the novel proteasome inhibitor NPI-0052 contributes to its TRAIL-enhanced apoptosis in cancer cells.
Topics: Apoptosis; Boronic Acids; Bortezomib; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Hematopoietic Stem Cells; Humans; Lactones; Neoplasms; NF-kappa B; Protease Inhibitors; Pyrazines; Pyrroles; Receptors, TNF-Related Apoptosis-Inducing Ligand; RNA, Messenger; RNA, Small Interfering; TNF-Related Apoptosis-Inducing Ligand; Transcription, Genetic; Up-Regulation; YY1 Transcription Factor | 2008 |
BCL-2 phosphorylation modulates sensitivity to the BH3 mimetic GX15-070 (Obatoclax) and reduces its synergistic interaction with bortezomib in chronic lymphocytic leukemia cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Boronic Acids; Bortezomib; Drug Synergism; Humans; Indoles; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Mantle-Cell; Mitochondria; Phosphorylation; Protease Inhibitors; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Pyrroles; Tumor Cells, Cultured | 2008 |
Proteasome inhibition activates epidermal growth factor receptor (EGFR) and EGFR-independent mitogenic kinase signaling pathways in pancreatic cancer cells.
Topics: Adenocarcinoma; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Bevacizumab; Blotting, Western; Boronic Acids; Bortezomib; Cell Line, Tumor; Cetuximab; Deoxycytidine; ErbB Receptors; Erlotinib Hydrochloride; Female; Gemcitabine; Humans; Lactones; Mice; Mice, Nude; Pancreatic Neoplasms; Phosphatidylinositol 3-Kinases; Protease Inhibitors; Proteasome Inhibitors; Pyrazines; Pyrroles; Quinazolines; Signal Transduction; Xenograft Model Antitumor Assays | 2008 |
Caspase-8 dependent histone acetylation by a novel proteasome inhibitor, NPI-0052: a mechanism for synergy in leukemia cells.
Topics: Acetylation; Antioxidants; Apoptosis; Boronic Acids; Bortezomib; Caspase 8; Drug Synergism; Drug Therapy, Combination; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Immunoblotting; Immunoprecipitation; Lactones; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid, Acute; Oxidative Stress; Protease Inhibitors; Proteasome Inhibitors; Protein Processing, Post-Translational; Pyrazines; Pyrroles; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Superoxides; Tumor Cells, Cultured; Vorinostat | 2009 |
Control of HIF-1alpha expression by eIF2 alpha phosphorylation-mediated translational repression.
Topics: Basic Helix-Loop-Helix Transcription Factors; Boronic Acids; Bortezomib; Cell Line, Tumor; Down-Regulation; Eukaryotic Initiation Factor-2; Gene Expression Regulation; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lactones; Phosphorylation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Biosynthesis; Pyrazines; Pyrroles; RNA, Messenger; Vascular Endothelial Growth Factor A | 2009 |
Identification of potential cellular targets of aloisine A by affinity chromatography.
Topics: Animals; Brain; Chromatography, Affinity; Cyclin-Dependent Kinases; Glycogen Synthase Kinase 3; Plasmodium falciparum; Protein Binding; Pyrazines; Pyrroles; Saccharomyces cerevisiae; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Swine | 2009 |
Strategy for the identification of key odorants: application to shrimp aroma.
Topics: Analytic Sample Preparation Methods; Animals; Atlantic Ocean; Databases, Factual; Gas Chromatography-Mass Spectrometry; Head; Humans; Hydrazines; Indicators and Reagents; Methylamines; Molecular Structure; Odorants; Pandalidae; Polymers; Pyrazines; Pyrroles; Shellfish; Software; Volatilization | 2009 |
Pivotal roles of snail inhibition and RKIP induction by the proteasome inhibitor NPI-0052 in tumor cell chemoimmunosensitization.
Topics: Adenocarcinoma; Antineoplastic Agents; Apoptosis; Blotting, Western; Boronic Acids; Bortezomib; Cisplatin; Humans; Lactones; Leupeptins; Male; Melanoma; Membrane Potential, Mitochondrial; NF-kappa B; Phosphatidylethanolamine Binding Protein; Prostatic Neoplasms; Proteasome Inhibitors; Proto-Oncogene Proteins c-raf; Pyrazines; Pyrroles; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Snail Family Transcription Factors; TNF-Related Apoptosis-Inducing Ligand; Transcription Factors; Transfection; Tumor Cells, Cultured | 2009 |
Proteasome inhibitors activate autophagy as a cytoprotective response in human prostate cancer cells.
Topics: Animals; Autophagy; Autophagy-Related Protein 5; Autophagy-Related Protein 7; Boronic Acids; Bortezomib; Cell Line; Cell Line, Tumor; Cell Survival; Humans; Immunoblotting; Lactones; Lysosomes; Male; Microscopy, Electron, Transmission; Microtubule-Associated Proteins; Phagosomes; Prostatic Neoplasms; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Pyrroles; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Ubiquitin-Activating Enzymes | 2010 |
[A drug with the broad spectrum of pharmacological activity for the treatment of complex neuropsychic disorders].
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Male; Nootropic Agents; Pyrazines; Pyrroles; Rats; Toxicity Tests, Acute | 2010 |
Heme oxygenase-1 upregulation improves lipopolysaccharide-induced acute lung injury involving suppression of macrophage migration inhibitory factor.
Topics: Acute Lung Injury; Animals; Cell Line; Cell Movement; Gene Expression Regulation; Heme Oxygenase-1; Inflammation; Intramolecular Oxidoreductases; Lipopolysaccharides; Macrophage Migration-Inhibitory Factors; Macrophages; Male; Membrane Proteins; Mice; Mice, Inbred BALB C; Pyrazines; Pyrroles; RNA, Small Interfering; Specific Pathogen-Free Organisms; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha; Up-Regulation | 2010 |
Pyrrolo[1,2-a]pyrazine and pyrazolo[1,5-a]pyrazine: novel, potent, and selective series of Vasopressin 1b receptor antagonists.
Topics: Antidiuretic Hormone Receptor Antagonists; Pyrazines; Pyrroles; Structure-Activity Relationship | 2010 |
Domino approach for the synthesis of pyrrolo[1,2-alpha]pyrazine from vinyl azides.
Topics: Aldehydes; Azides; Molecular Structure; Pyrazines; Pyrroles; Stereoisomerism; Vinyl Compounds | 2010 |
Synthesis and characterization of a iodine-125-labeled pyrrolo[1,2-a]thieno[3,2-e]pyrazine and evaluation as a potential 5-HT4R SPECT tracer.
Topics: Chromatography, High Pressure Liquid; Iodine Radioisotopes; Magnetic Resonance Spectroscopy; Pyrazines; Pyrroles; Thiophenes; Tomography, Emission-Computed, Single-Photon | 2010 |
Solid-phase synthesis of azaphthalocyanine-oligonucleotide conjugates and their evaluation as new dark quenchers of fluorescence.
Topics: Absorption; Base Sequence; Chromatography, High Pressure Liquid; Fluorescent Dyes; Oligonucleotide Probes; Oligonucleotides; Pyrazines; Pyrroles; Spectrometry, Fluorescence; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2010 |
Inhibition of activated receptor tyrosine kinases by Sunitinib induces growth arrest and sensitizes melanoma cells to Bortezomib by blocking Akt pathway.
Topics: Antineoplastic Agents; Boronic Acids; Bortezomib; Cell Line, Tumor; Cell Proliferation; Chromones; Humans; Indoles; Melanoma; Morpholines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrazines; Pyrroles; Receptor Protein-Tyrosine Kinases; Receptor, Platelet-Derived Growth Factor alpha; RNA, Small Interfering; Signal Transduction; Sunitinib; Vascular Endothelial Growth Factor Receptor-2 | 2012 |
S35972, a direct-acting thrombin inhibitor with high oral bioavailability and antithrombotic efficacy.
Topics: Administration, Oral; Animals; Anticoagulants; Benzimidazoles; Biological Availability; Blood Coagulation Tests; Dabigatran; Disease Models, Animal; Dogs; Drug Evaluation; Humans; In Vitro Techniques; Inhibitory Concentration 50; Pyrazines; Pyridines; Pyrroles; Rats; Thrombin; Thrombosis | 2011 |
The histone deacetylase inhibitor entinostat (SNDX-275) induces apoptosis in Hodgkin lymphoma cells and synergizes with Bcl-2 family inhibitors.
Topics: Acetylation; Apoptosis; Apoptosis Regulatory Proteins; Benzamides; Biphenyl Compounds; Boronic Acids; Bortezomib; Cyclin-Dependent Kinase Inhibitor p21; Deoxycytidine; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Drug Synergism; Gemcitabine; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Histones; Hodgkin Disease; Humans; Indoles; Lymphoma, Non-Hodgkin; Neoplasm Proteins; Nitrophenols; Piperazines; Protein Processing, Post-Translational; Pyrazines; Pyridines; Pyrroles; Sulfonamides; Tumor Cells, Cultured; X-Linked Inhibitor of Apoptosis Protein | 2011 |
Direct synthesis of chiral 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazines via a catalytic asymmetric intramolecular aza-Friedel-Crafts reaction.
Topics: Catalysis; Crystallography, X-Ray; Models, Molecular; Molecular Structure; Phosphoric Acids; Pyrazines; Pyrroles; Stereoisomerism | 2011 |
Bacterial self-resistance to the natural proteasome inhibitor salinosporamide A.
Topics: Actinobacteria; Biological Products; Boronic Acids; Bortezomib; Drug Resistance, Bacterial; Humans; Lactones; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Subunits; Pyrazines; Pyrroles; Substrate Specificity | 2011 |
Heme oxygenase-1 ameliorates LPS-induced acute lung injury correlated with downregulation of interleukin-33.
Topics: Acute Lung Injury; Animals; Down-Regulation; Heme Oxygenase-1; Interleukin-33; Interleukins; Lipopolysaccharides; Macrophages; Male; Membrane Proteins; Mice; Mice, Inbred BALB C; Neutrophil Infiltration; Pyrazines; Pyrroles; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha | 2011 |
Rhabdomyolysis precipitated by a sitagliptin-atorvastatin drug interaction.
Topics: Aged; Atorvastatin; Drug Interactions; Drug Therapy, Combination; Heptanoic Acids; Humans; Male; Pyrazines; Pyrroles; Rhabdomyolysis; Sitagliptin Phosphate; Treatment Outcome; Triazoles | 2012 |
[Renal tolerance of targeted therapies].
Topics: Antibodies, Monoclonal; Benzenesulfonates; Boronic Acids; Bortezomib; Erlotinib Hydrochloride; Glomerulonephritis; Humans; Indoles; Kidney; Kidney Tubules; Lapatinib; Molecular Targeted Therapy; Niacinamide; Phenylurea Compounds; Protein Kinase Inhibitors; Pyrazines; Pyridines; Pyrroles; Quinazolines; Sirolimus; Sorafenib; Sunitinib | 2012 |
The pan-histone deacetylase inhibitor CR2408 disrupts cell cycle progression, diminishes proliferation and causes apoptosis in multiple myeloma cells.
Topics: Acetylation; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Boronic Acids; Bortezomib; Cell Cycle; Cell Proliferation; Dose-Response Relationship, Drug; Doxorubicin; Drug Evaluation, Preclinical; Drug Synergism; Histone Deacetylase Inhibitors; Histones; Humans; Multiple Myeloma; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Pyrroles; Signal Transduction; Sulfonamides; Tumor Cells, Cultured | 2012 |
Hypoxia-inducible factor-1α inhibition by a pyrrolopyrazine metabolite of oltipraz as a consequence of microRNAs 199a-5p and 20a induction.
Topics: Cell Hypoxia; Cell Line, Tumor; Cell Movement; Cobalt; HT29 Cells; Humans; Hydrogen Peroxide; Hypoxia-Inducible Factor 1, alpha Subunit; Insulin; MicroRNAs; Neoplasm Invasiveness; Neovascularization, Pathologic; Pyrazines; Pyridazines; Pyrroles; Thiones; Thiophenes | 2012 |
Static headspace analysis using polyurethane phases--application to roasted coffee volatiles characterization.
Topics: Adsorption; Coffee; Dimethylpolysiloxanes; Furans; Gas Chromatography-Mass Spectrometry; Ketones; Polyurethanes; Pyrazines; Pyrroles; Sensitivity and Specificity; Solid Phase Microextraction; Volatile Organic Compounds | 2012 |
Analysing properties of proteasome inhibitors using kinetic and X-ray crystallographic studies.
Topics: Antineoplastic Agents; Boronic Acids; Bortezomib; Crystallography, X-Ray; Drug Design; Enzyme Inhibitors; Lactones; Multiple Myeloma; Oligopeptides; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Pyrroles; Saccharomyces cerevisiae; Threonine | 2012 |
Blockade of NFκB activity by Sunitinib increases cell death in Bortezomib-treated endometrial carcinoma cells.
Topics: Antineoplastic Agents; Apoptosis; Boronic Acids; Bortezomib; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Synergism; Endometrial Neoplasms; Endometrium; Female; Humans; Indoles; NF-kappa B; Pyrazines; Pyrroles; Sunitinib | 2012 |
Carbon monoxide reduces neuropathic pain and spinal microglial activation by inhibiting nitric oxide synthesis in mice.
Topics: Animals; Carbon Monoxide; CD11b Antigen; CD11c Antigen; Enzyme Induction; Ganglia, Spinal; Gene Expression Regulation, Enzymologic; Gene Knockout Techniques; Heme Oxygenase-1; Male; Mice; Microglia; Neuralgia; Nitric Oxide; Nitric Oxide Synthase Type II; Organometallic Compounds; Pyrazines; Pyrroles; Sciatic Nerve; Spinal Cord | 2012 |
Vinyl azides derived from allenes: thermolysis leading to multisubstituted 1,4-pyrazines and Mn(III)-catalyzed photochemical reaction leading to pyrroles.
Topics: Azides; Catalysis; Crystallography, X-Ray; Manganese; Molecular Structure; Photochemical Processes; Pyrazines; Pyrroles; Vinyl Compounds | 2012 |
The unexpected and facile molybdenum mediated formation of tri- and tetracyclic pentathiepins from pyrazine-alkynes and sulfur.
Topics: Alkynes; Catalysis; Crystallography, X-Ray; Molecular Conformation; Molybdenum; Pyrazines; Pyridazines; Pyrroles; Sulfur; Thiepins | 2013 |
3-Amido pyrrolopyrazine JAK kinase inhibitors: development of a JAK3 vs JAK1 selective inhibitor and evaluation in cellular and in vivo models.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caco-2 Cells; Crystallography, X-Ray; Cyclopropanes; Gene Knockdown Techniques; High-Throughput Screening Assays; Humans; Interleukin-2; Janus Kinase 1; Janus Kinase 3; Mice; Models, Molecular; Pyrazines; Pyrroles; Rats; Receptors, Interleukin-6; RNA, Small Interfering; Signal Transduction; Structure-Activity Relationship; T-Lymphocytes | 2013 |
Design and synthesis of tricyclic cores for kinase inhibition.
Topics: Cells, Cultured; Cyclization; Drug Design; Enzyme Activation; Inhibitory Concentration 50; Molecular Structure; Protein Kinase Inhibitors; Pyrazines; Pyridines; Pyrroles | 2013 |
Pyrrolopyrazines as selective spleen tyrosine kinase inhibitors.
Topics: Animals; B-Lymphocytes; Blood Proteins; Crystallography, X-Ray; Humans; Intracellular Signaling Peptides and Proteins; Mice; Microsomes, Liver; Models, Molecular; Molecular Structure; Protein Binding; Protein-Tyrosine Kinases; Pyrazines; Pyrroles; Structure-Activity Relationship; Syk Kinase | 2013 |
[Molecular targeting agents for multiple myeloma].
Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Boron Compounds; Boronic Acids; Bortezomib; Glycine; Histone Deacetylases; Humans; Immunologic Factors; Lactones; Lenalidomide; Molecular Targeted Therapy; Multiple Myeloma; Oligopeptides; Proteasome Inhibitors; Pyrazines; Pyrroles; Thalidomide | 2012 |
Simultaneous analysis of anticancer agents bortezomib, imatinib, nilotinib, dasatinib, erlotinib, lapatinib, sorafenib, sunitinib and vandetanib in human plasma using LC/MS/MS.
Topics: Antineoplastic Agents; Benzamides; Boronic Acids; Bortezomib; Chromatography, Liquid; Dasatinib; Erlotinib Hydrochloride; Humans; Imatinib Mesylate; Indoles; Lapatinib; Niacinamide; Phenylurea Compounds; Piperazines; Piperidines; Pyrazines; Pyrimidines; Pyrroles; Quinazolines; Reproducibility of Results; Sorafenib; Sunitinib; Tandem Mass Spectrometry; Thiazoles | 2013 |
Inhibition of c-Met reduces lymphatic metastasis in RIP-Tag2 transgenic mice.
Topics: Animals; Antibodies; Antineoplastic Agents; Gene Expression Regulation, Neoplastic; Immunohistochemistry; Indoles; Lymphatic Metastasis; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microscopy, Confocal; Pancreatic Neoplasms; Phosphorylation; Proto-Oncogene Proteins c-met; Pyrazines; Pyrroles; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Sunitinib; Triazoles; Vascular Endothelial Growth Factor C | 2013 |
Evaluation of process parameters governing the aroma generation in three hazelnut cultivars (Corylus avellana L.) by correlating quantitative key odorant profiling with sensory evaluation.
Topics: Alkenes; Biomarkers; Corylus; Distillation; Flame Ionization; Food Handling; Food Inspection; Food Quality; Gas Chromatography-Mass Spectrometry; Humans; Italy; Ketones; Nuts; Odorants; Olfactometry; Pyrazines; Pyrroles; Sensation; Turkey; Volatile Organic Compounds | 2013 |
Aroma-active components of yeast extract pastes with a basic and characteristic meaty flavour.
Topics: Aldehydes; China; Diacetyl; Female; Flavoring Agents; Food Preferences; Furans; Humans; Ketones; Male; Odorants; Principal Component Analysis; Pyrazines; Pyrroles; Saccharomyces cerevisiae; Stereoisomerism; Sulfhydryl Compounds; Taste; Vinyl Compounds | 2014 |
Design, stereoselective synthesis, and biological evaluation of novel tri-cyclic compounds as inhibitor of apoptosis proteins (IAP) antagonists.
Topics: Animals; Benzopyrans; Binding Sites; Breast Neoplasms; Cell Line, Tumor; Crystallography, X-Ray; Drug Design; Female; Half-Life; Humans; Inhibitor of Apoptosis Proteins; Mice; Molecular Dynamics Simulation; Protein Structure, Tertiary; Pyrazines; Pyrroles; RNA, Messenger; Stereoisomerism; Transplantation, Heterologous; Tumor Necrosis Factor-alpha | 2013 |
A comparative analysis of the influence of human salivary enzymes on odorant concentration in three palm wines.
Topics: Aldehydes; Arecaceae; Esters; Humans; Plant Extracts; Pyrazines; Pyrroles; Saliva; Wine | 2013 |
Structure-activity relationships of the aromatic site in novel anticonvulsant pyrrolo[1,2-a]pyrazine derivatives.
Topics: Animals; Anticonvulsants; Male; Mice; Pyrazines; Pyrroles; Rats; Rats, Sprague-Dawley; Status Epilepticus; Structure-Activity Relationship | 2013 |
A novel method for beef potentiator preparation and identification of its characteristic aroma compounds.
Topics: Adult; Alcohols; Animals; Aspergillus; Aspergillus niger; Aspergillus oryzae; Cattle; Female; Fermentation; Flavoring Agents; Gas Chromatography-Mass Spectrometry; Humans; Maillard Reaction; Male; Meat; Middle Aged; Odorants; Pyrazines; Pyrroles; Smell; Sulfur Compounds; Taste | 2014 |
Antileukemic activity and mechanism of drug resistance to the marine Salinispora tropica proteasome inhibitor salinosporamide A (Marizomib).
Topics: Actinobacteria; Boronic Acids; Bortezomib; Catalysis; Cell Line, Tumor; Drug Resistance, Neoplasm; Humans; Lactones; Leukemia; Mutation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Pyrroles; Up-Regulation | 2014 |
Critical neuroprotective roles of heme oxygenase-1 induction against axonal injury-induced retinal ganglion cell death.
Topics: Animals; Axons; Disease Models, Animal; Flow Cytometry; Gene Expression Profiling; Gene Expression Regulation; Heme Oxygenase-1; Male; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Neuroprotective Agents; Oligonucleotide Array Sequence Analysis; Optic Nerve Injuries; Protoporphyrins; Pyrazines; Pyrroles; Retinal Ganglion Cells; Statistics, Nonparametric; Stilbamidines; Time Factors | 2014 |
Iridium-catalyzed asymmetric hydrogenation of pyrrolo[1,2-a]pyrazinium salts.
Topics: Carbonates; Catalysis; Cesium; Hydrogenation; Iridium; Molecular Structure; Pyrazines; Pyrroles; Salts | 2014 |
Targeting SQSTM1/p62 induces cargo loading failure and converts autophagy to apoptosis via NBK/Bik.
Topics: Adaptor Proteins, Signal Transducing; Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Boronic Acids; Bortezomib; Cell Line, Tumor; Cells, Cultured; Cyclin T; Cyclin-Dependent Kinase 9; Cycloheximide; Flavonoids; Gene Expression Regulation; Heat-Shock Proteins; Humans; Indoles; Leupeptins; Membrane Proteins; Mice; Mice, Knockout; Mitochondrial Proteins; Piperidines; Protein Transport; Pyrazines; Pyrroles; RNA, Small Interfering; Sequestosome-1 Protein | 2014 |
Novel fluorinated pyrrolo[1,2-a]pyrazine-2,6-dione derivatives: synthesis and anticonvulsant evaluation in animal models of epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Epilepsy; Halogenation; Hydrocarbons, Fluorinated; Male; Mice; Molecular Structure; Pentylenetetrazole; Pilocarpine; Pyrazines; Pyrroles; Rats; Rats, Sprague-Dawley; Seizures; Structure-Activity Relationship | 2014 |
Synthesis of the new ring system bispyrido[4',3':4,5]pyrrolo [1,2-a:1',2'-d]pyrazine and its deaza analogue.
Topics: Antineoplastic Agents; Carboxylic Acids; Drug Screening Assays, Antitumor; Heterocyclic Compounds; Humans; MCF-7 Cells; Pyrazines; Pyrroles | 2014 |
Scaffold hopping towards potent and selective JAK3 inhibitors: discovery of novel C-5 substituted pyrrolopyrazines.
Topics: Drug Design; Humans; Janus Kinase 3; Models, Molecular; Molecular Conformation; Molecular Structure; Phosphorylation; Piperidines; Protein Kinase Inhibitors; Pyrazines; Pyrimidines; Pyrroles; Structure-Activity Relationship | 2014 |
Nannozinones and sorazinones, unprecedented pyrazinones from myxobacteria.
Topics: Anti-Bacterial Agents; Antifungal Agents; Gram-Positive Bacteria; Humans; Indoles; Microbial Sensitivity Tests; Molecular Structure; Myxococcales; Pyrazines; Pyrroles; Soil Microbiology; Spain | 2014 |
Efficacy of panobinostat and marizomib in acute myeloid leukemia and bortezomib-resistant models.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Boronic Acids; Bortezomib; Caspases; Cell Proliferation; Drug Combinations; Drug Resistance, Neoplasm; Flow Cytometry; Humans; Hydroxamic Acids; Indoles; Lactones; Leukemia, Myeloid, Acute; Panobinostat; Proteasome Inhibitors; Pyrazines; Pyrroles; Tumor Cells, Cultured | 2015 |
The MET Inhibitor AZD6094 (Savolitinib, HMPL-504) Induces Regression in Papillary Renal Cell Carcinoma Patient-Derived Xenograft Models.
Topics: Animals; Antineoplastic Agents; Carcinoma, Papillary; Carcinoma, Renal Cell; Cell Line, Tumor; Crizotinib; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Humans; Indoles; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-met; Pyrazines; Pyrazoles; Pyridines; Pyrroles; Sunitinib; Triazines; Tumor Burden; Xenograft Model Antitumor Assays | 2015 |
Design of pyrazolo-pyrrolo-pyrazines and pyrazolo-pyrrolo-diazepines via AuCl₃-catalyzed and NaH-supported cyclization of N-propargyl pyrazoles.
Topics: Azepines; Catalysis; Cyclization; Gold Compounds; Molecular Structure; Morphinans; Pyrazines; Pyrazoles; Pyrroles | 2015 |
Fragment-based discovery of potent ERK2 pyrrolopyrazine inhibitors.
Topics: Dose-Response Relationship, Drug; Drug Discovery; Humans; Mitogen-Activated Protein Kinase 1; Models, Molecular; Molecular Structure; Pyrazines; Pyrroles; Structure-Activity Relationship | 2015 |
Synthesis of Hydroxypyrrolone Carboxamides Employing Selectfluor.
Topics: Catalysis; Diazonium Compounds; Hydrocarbons, Brominated; Molecular Structure; Pyrazines; Pyrroles; Stereoisomerism | 2016 |
Synthesis and Mechanism Studies of 1,3-Benzoazolyl Substituted Pyrrolo[2,3-b]pyrazine Derivatives as Nonintercalative Topoisomerase II Catalytic Inhibitors.
Topics: Antineoplastic Agents; Apoptosis; Catalysis; Cell Line, Tumor; Cell Proliferation; DNA; DNA Helicases; DNA Topoisomerases, Type II; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Molecular Docking Simulation; Pyrazines; Pyrroles; Receptors, Purinergic P2; Structure-Activity Relationship; Topoisomerase II Inhibitors | 2016 |
The antinociceptive effects of a δ-opioid receptor agonist in mice with painful diabetic neuropathy: Involvement of heme oxygenase 1.
Topics: Analgesics, Opioid; Animals; Diabetic Neuropathies; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enzyme Induction; Heme Oxygenase-1; Hyperalgesia; Injections, Subcutaneous; Male; Mice, Inbred C57BL; Organometallic Compounds; Physical Stimulation; Pyrazines; Pyrroles; Receptors, Opioid, delta; Ruthenium | 2016 |
Anticancer potential of pyrrole (1, 2, a) pyrazine 1, 4, dione, hexahydro 3-(2-methyl propyl) (PPDHMP) extracted from a new marine bacterium, Staphylococcus sp. strain MB30.
Topics: Antineoplastic Agents; Apoptosis Regulatory Proteins; Cell Line, Tumor; Cell Movement; DNA Fragmentation; Geologic Sediments; Humans; Molecular Docking Simulation; Pyrazines; Pyrroles; Staphylococcus; Water Microbiology | 2016 |
Optimisation of a 5-[3-phenyl-(2-cyclic-ether)-methyl-ether]-4-aminopyrrolopyrimidine series of IGF-1R inhibitors.
Topics: Animals; Antineoplastic Agents; Cell Proliferation; Dose-Response Relationship, Drug; Humans; Imidazoles; Mice; Mice, Nude; Molecular Structure; Neoplasms, Experimental; NIH 3T3 Cells; Protein Kinase Inhibitors; Pyrazines; Pyrimidines; Pyrroles; Receptor, IGF Type 1; Structure-Activity Relationship; Xenograft Model Antitumor Assays | 2016 |
Antinociceptive activity of intraperitoneally administered novel and potent anticonvulsive compound, CY-PROLL-SS, in animal neuropathic pain models.
Topics: Analgesics; Animals; Anticonvulsants; Disease Models, Animal; Injections, Intraperitoneal; Male; Neuralgia; Pain Measurement; Pyrazines; Pyrroles; Rats; Streptozocin | 2016 |
Circulating Neutrophil Extracellular Trap Levels in Well-Controlled Type 2 Diabetes and Pathway Involved in Their Formation Induced by High-Dose Glucose.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Case-Control Studies; Diabetes Mellitus, Type 2; Diabetic Angiopathies; DNA; Dose-Response Relationship, Drug; Extracellular Traps; Glucose; Humans; Hypoglycemic Agents; Middle Aged; Neutrophils; Peroxidase; Polymers; Pyrazines; Pyrroles; Quinazolines; Risk Factors; Spiro Compounds; Time Factors | 2016 |
Human heme oxygenase 1 is a potential host cell factor against dengue virus replication.
Topics: Animals; Biliverdine; Carbon Monoxide; Dengue; Dengue Virus; Disease Models, Animal; Diterpenes; Enzyme Inhibitors; Heme Oxygenase-1; Host-Pathogen Interactions; Humans; Interferon-alpha; Iron; Metalloporphyrins; Mice, Inbred ICR; Protoporphyrins; Pyrazines; Pyrroles; Serine Endopeptidases; Virus Replication | 2016 |
IGF-1R and mTOR Blockade: Novel Resistance Mechanisms and Synergistic Drug Combinations for Ewing Sarcoma.
Topics: Adenosine Triphosphatases; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cation Transport Proteins; Cell Line, Tumor; Copper-Transporting ATPases; Drug Resistance, Neoplasm; Drug Synergism; Humans; Imidazoles; Insulin Receptor Substrate Proteins; Male; Mice; Mice, SCID; Neoplasm Transplantation; Nucleocytoplasmic Transport Proteins; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Protein Array Analysis; Pyrazines; Pyrimidines; Pyrroles; Receptor, IGF Type 1; Receptors, Somatomedin; Sarcoma, Ewing; Sirolimus; STAT3 Transcription Factor; TOR Serine-Threonine Kinases; Up-Regulation | 2016 |
Rhodium/Silver-Cocatalyzed Transannulation of N-Sulfonyl-1,2,3-triazoles with Vinyl Azides: Divergent Synthesis of Pyrroles and 2 H-Pyrazines.
Topics: Azides; Catalysis; Cyclization; Pyrazines; Pyrroles; Rhodium; Silver; Triazoles | 2016 |
Carbon Monoxide Inhibits Porcine Reproductive and Respiratory Syndrome Virus Replication by the Cyclic GMP/Protein Kinase G and NF-κB Signaling Pathway.
Topics: Animals; Antiviral Agents; Carbon Monoxide; Cell Line; Chlorocebus aethiops; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cytokines; Epithelial Cells; Gene Expression Regulation; Heme Oxygenase-1; Host-Pathogen Interactions; Macrophages, Alveolar; NF-kappa B; Organometallic Compounds; Porcine respiratory and reproductive syndrome virus; Pyrazines; Pyrroles; RNA, Messenger; Signal Transduction; Swine; Virus Internalization; Virus Replication | 2017 |
Value-added organonitrogen chemicals evolution from the pyrolysis of chitin and chitosan.
Topics: Chitin; Chitosan; Gas Chromatography-Mass Spectrometry; Hot Temperature; Pyrazines; Pyridines; Pyrroles; Thermogravimetry; Volatilization | 2017 |
Insulin-like growth factor-1 signaling is responsible for cathepsin G-induced aggregation of breast cancer MCF-7 cells.
Topics: Autocrine Communication; Axitinib; Breast Neoplasms; Cathepsin G; Cell Aggregation; Female; Humans; Imidazoles; Indazoles; Indoles; Insulin-Like Growth Factor I; MCF-7 Cells; Phosphorylation; Pyrazines; Pyrroles; Receptor, IGF Type 1; Receptors, Somatomedin; Signal Transduction; Small Molecule Libraries; Sunitinib | 2017 |
Growth media affect the volatilome and antimicrobial activity against Phytophthora infestans in four Lysobacter type strains.
Topics: Acetoin; Aldehydes; Anti-Infective Agents; Biological Control Agents; Carbohydrate Metabolism; Culture Media; Ethanol; Gas Chromatography-Mass Spectrometry; Indoles; Lysobacter; Mass Spectrometry; Microbial Interactions; Phytophthora infestans; Proteins; Pyrazines; Pyrroles; Soil; Soil Microbiology; Volatile Organic Compounds | 2017 |
LC-ESI-MS/MS determination of defactinib, a novel FAK inhibitor in mice plasma and its application to a pharmacokinetic study in mice.
Topics: Animals; Area Under Curve; Benzamides; Carbon Isotopes; Chromatography, High Pressure Liquid; Drug Stability; Focal Adhesion Kinase 1; Limit of Detection; Liquid-Liquid Extraction; Male; Mice; Mice, Inbred BALB C; Nitrogen Isotopes; Piperidines; Protein Kinase Inhibitors; Pyrazines; Pyrimidines; Pyrroles; Reference Standards; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Sulfonamides; Tandem Mass Spectrometry | 2018 |
Mechanism implicated in the anti-allodynic and anti-hyperalgesic effects induced by the activation of heme oxygenase 1/carbon monoxide signaling pathway in the central nervous system of mice with neuropathic pain.
Topics: Animals; Carbon Monoxide; Central Nervous System; Gene Expression Regulation; Heme Oxygenase-1; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Neuralgia; Organometallic Compounds; Pyrazines; Pyrroles; Sciatic Nerve; Signal Transduction | 2018 |
Strong enhancement by IGF1-R antagonists of hepatocellular carcinoma cell migration inhibition by Sorafenib and/or vitamin K1.
Topics: Actin Cytoskeleton; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Proliferation; Extracellular Signal-Regulated MAP Kinases; Humans; Imidazoles; Insulin-Like Growth Factor I; Liver Neoplasms; Niacinamide; Phenylurea Compounds; Phosphorylation; Protein Kinase Inhibitors; Pyrazines; Pyrimidines; Pyrroles; Sorafenib; Vitamin K 1 | 2018 |
Chemo-Enzymatic Synthesis of Pyrazines and Pyrroles.
Topics: Molecular Structure; Pyrazines; Pyrroles; Transaminases | 2018 |
Antimicrobial potential of haloalkaliphilic Nocardiopsis sp. AJ1 isolated from solar salterns in India.
Topics: Acetates; Anti-Infective Agents; Bacteria; Bacterial Proteins; Dactinomycin; Fungi; Microbial Sensitivity Tests; Models, Molecular; Nocardia; Peptide Synthases; Phylogeny; Pyrazines; Pyrroles; RNA, Ribosomal, 16S; Salinity; Soil Microbiology; Viruses | 2019 |
Pod storage with roasting: A tool to diversifying the flavor profiles of dark chocolates produced from 'bulk' cocoa beans? (part I: aroma profiling of chocolates).
Topics: Cacao; Chocolate; Cote d'Ivoire; Ecuador; Esters; Food Handling; Food Storage; Furans; Gas Chromatography-Mass Spectrometry; Ghana; Madagascar; Odorants; Pyrans; Pyrazines; Pyrones; Pyrroles; Seeds; Solid Phase Microextraction; Taste; Terpenes; Venezuela; Vietnam; Volatile Organic Compounds | 2019 |
Positive Effects of Heme Oxygenase Upregulation on Adiposity and Vascular Dysfunction: Gene Targeting vs. Pharmacologic Therapy.
Topics: Adiposity; Animals; Cell Line; Endothelial Cells; Enzyme Activators; Gene Targeting; Genetic Therapy; Heme Oxygenase-1; Male; Mice, Inbred C57BL; Obesity; Pyrazines; Pyrroles; Up-Regulation; Vasodilation | 2019 |
Comparison of effects of midostaurin, crenolanib, quizartinib, gilteritinib, sorafenib and BLU-285 on oncogenic mutants of KIT, CBL and FLT3 in haematological malignancies.
Topics: Aniline Compounds; Antineoplastic Agents; Benzimidazoles; Benzothiazoles; Cell Line, Tumor; Drug Screening Assays, Antitumor; fms-Like Tyrosine Kinase 3; Hematologic Neoplasms; Humans; Mutant Proteins; Phenylurea Compounds; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-cbl; Proto-Oncogene Proteins c-kit; Pyrazines; Pyrazoles; Pyrroles; Sorafenib; Staurosporine; Triazines | 2019 |
Tolerogenic dendritic cell transfer ameliorates systemic lupus erythematosus in mice.
Topics: Animals; Antibodies, Antinuclear; Cell Differentiation; Cells, Cultured; Dendritic Cells; Dexamethasone; Disease Models, Animal; Humans; Immune Tolerance; Immunotherapy, Adoptive; Kidney; Lupus Erythematosus, Systemic; Lymphocyte Activation; Mice; Mice, Inbred MRL lpr; Pyrazines; Pyrroles; Rosiglitazone; T-Lymphocytes, Regulatory | 2019 |
Expansion of chemical space based on a pyrrolo[1,2-a]pyrazine core: Synthesis and its anticancer activity in prostate cancer and breast cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Caspase 3; Cell Line, Tumor; Cell Movement; Cell Survival; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Poly(ADP-ribose) Polymerases; Pyrazines; Pyrroles | 2020 |
Targeting Insulin-Like Growth Factor 1 Receptor Delays M-Phase Progression and Synergizes with Aurora B Inhibition to Suppress Cell Proliferation.
Topics: Apoptosis; Aurora Kinase B; Benzamides; Cell Differentiation; Cell Division; Cell Line, Tumor; Cell Proliferation; Cell Survival; Disease Progression; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Imidazoles; Pyrazines; Pyrimidines; Pyrroles; Quinazolines; Receptor, IGF Type 1; Transcription, Genetic | 2020 |
The selective PGI2 receptor agonist selexipag ameliorates Sugen 5416/hypoxia-induced pulmonary arterial hypertension in rats.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetamides; Animals; Cell Proliferation; Collagen Type I; Disease Models, Animal; Heart Ventricles; Hemodynamics; Hypertrophy, Right Ventricular; Hypoxia; Indoles; Lung; Male; Pulmonary Arterial Hypertension; Pyrazines; Pyrroles; Rats, Sprague-Dawley; Receptors, Epoprostenol; Systole; Vascular Remodeling | 2020 |
The cytoskeleton actin binding protein filamin A impairs both IGF2 mitogenic effects and the efficacy of IGF1R inhibitors in adrenocortical cancer cells.
Topics: Actin Cytoskeleton; Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Apoptosis; Biomarkers, Tumor; Cell Proliferation; Filamins; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Insulin-Like Growth Factor II; Mitogens; Pyrazines; Pyrimidines; Pyrroles; Receptor, IGF Type 1; Receptor, Insulin; Signal Transduction; Tumor Cells, Cultured | 2021 |
Novel β-Glucocerebrosidase Activators That Bind to a New Pocket at a Dimer Interface and Induce Dimerization.
Topics: Binding Sites; Crystallography, X-Ray; Enzyme Activators; Glucosylceramidase; Humans; Kinetics; Molecular Structure; Protein Binding; Protein Multimerization; Pyrazines; Pyrroles; Structure-Activity Relationship | 2021 |
HO-CO pathway activation may be associated with hippocampal μ and δ opioid receptors in inhibiting inflammatory pain aversiveness and nociception in WT but not NOS2-KO mice.
Topics: Animals; Avoidance Learning; Carbon Monoxide; Heme Oxygenase (Decyclizing); Hippocampus; Male; Mice; Mice, Knockout; Nociception; Organometallic Compounds; Pain; Pain Measurement; Pyrazines; Pyrroles; Receptors, Opioid, delta; Receptors, Opioid, mu; Signal Transduction | 2021 |
Rapid, High-Throughput Quantitation of Odor-Active 2-Acetyl Azaheterocycles in Food Products by UHPLC-MS/MS.
Topics: Chromatography, High Pressure Liquid; Flavoring Agents; Odorants; Oryza; Phenylhydrazines; Pyrazines; Pyrroles; Tandem Mass Spectrometry | 2021 |
Simultaneous quantification of seven repurposed COVID-19 drugs remdesivir (plus metabolite GS-441524), chloroquine, hydroxychloroquine, lopinavir, ritonavir, favipiravir and azithromycin by a two-dimensional isotope dilution LC-MS/MS method in human serum
Topics: Adenosine; Adenosine Monophosphate; Alanine; Amides; Antiviral Agents; Azithromycin; Chloroquine; Chromatography, Liquid; COVID-19; COVID-19 Drug Treatment; Furans; Humans; Hydroxychloroquine; Isotopes; Lopinavir; Pandemics; Pyrazines; Pyrroles; Ritonavir; SARS-CoV-2; Tandem Mass Spectrometry; Triazines | 2021 |
Discovery and Early Clinical Development of LY3202626, a Low-Dose, CNS-Penetrant BACE Inhibitor.
Topics: Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Blood-Brain Barrier; Brain; Crystallography, X-Ray; Dogs; Drug Stability; Heterocyclic Compounds, 2-Ring; Humans; Madin Darby Canine Kidney Cells; Male; Mice; Microsomes, Liver; Molecular Structure; Protease Inhibitors; Protein Binding; Pyrazines; Pyrroles; Rats; Structure-Activity Relationship | 2021 |
Discovery and characterization of a novel cGAS covalent inhibitor for the treatment of inflammatory bowel disease.
Topics: Animals; DNA; Immunity, Innate; Inflammatory Bowel Diseases; Mice; Nucleotidyltransferases; Pyrazines; Pyrroles; Signal Transduction | 2023 |
Pyrrole-Based Enaminones as Building Blocks for the Synthesis of Indolizines and Pyrrolo[1,2-
Topics: Antifungal Agents; Candida; Indolizines; Microbial Sensitivity Tests; Pyrazines; Pyrroles | 2023 |