Page last updated: 2024-08-18

pyrroles and pki 166

pyrroles has been researched along with pki 166 in 48 studies

Research

Studies (48)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	41 (85.42)	29.6817
2010's	7 (14.58)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Abbruzzese, J; Bruns, CJ; Buchdunger, E; Fan, D; Fidler, IJ; Harbison, MT; Ozawa, S; Radinsky, R; Solorzano, CC; Traxler, P; Tsan, R	1
Baker, CH; Buchdunger, E; Cohen, P; Fidler, IJ; Killion, JJ; Solorzano, CC; Traxler, P; Tsan, R	1
Brandt, R; Hynes, NE; Wong, AM	1
Fry, DW; Slichenmyer, WJ	1
Baker, CH; Fidler, IJ; Solorzano, CC	1
Hynes, NE; Lane, HA; Motoyama, AB	1
Baker, CH; Bucana, CD; Fidler, IJ; Kedar, D; McCarty, MF; Tsan, R; Weber, KL	1
Mellinghoff, IK; Sawyers, CL; Tran, C	1
Baselga, J; Hammond, LA	1
Baker, CH; Dinney, CP; Fidler, IJ; Kedar, D; Killion, JJ	1
Fidler, IJ; Karashima, T; Killion, JJ; Kim, SJ; Shepherd, DL; Uehara, H	1
Traxler, P	1
Baker, C; Doucet, M; Fidler, IJ; Kim, SJ; Price, JE; Weber, KL	1
Grünwald, V; Hidalgo, M	1
Bonomi, P	1
Bekele, BN; Bucana, CD; Doan, DD; Fidler, IJ; Greenberg, JS; Holsinger, FC; Jasser, SA; Myers, JN; Schiff, BA; Swan, EA; Younes, MN	1
Davidson, AJ; Goishi, K; Klagsbrun, M; Lee, P; Nishi, E; Zon, LI	1
Doucet, M; Price, JE; Weber, KL	1
Bucana, CD; Fidler, IJ	1
Bodis, S; Hofstetter, B; Pruschy, M; Riesterer, O; Tenzer, A; Vuong, V; Zingg, D	1
Aunoble, B; Bourhis, J; Rolhion, C; Tortochaux, J	1
Fidler, IJ; Yokoi, K	1
Fan, D; Fidler, IJ; He, J; Killion, JJ; Kim, SJ; Langley, RR; Tsan, R; Uehara, H; Yazici, S	1
Getsios, S; Green, KJ; Klessner, J; Lorch, JH; Park, JK; Stack, MS; Wu, YL	1
Bae, JH; Chung, BS; Ju, DS; Kang, CD; Kim, DW; Kim, MJ; Kim, SH; Kwon, JK; Um, JH	1
Gross, G; Kretz, O; Sugiyama, Y; Takada, T; Weiss, HM	1
Gilbert, RE; Kelly, DJ; Wassef, L	1
Kwon, A; Mellinghoff, IK; Sawyers, CL; Tran, C; Vivanco, I; Wongvipat, J	1
Fidler, IJ; Herbst, RS; Isobe, T; Itasaka, S; Kenji, Y; O'reilly, MS; Onn, A; Shibuya, K; Shintani, T; Wu, W	1
Barrio, J; Czernin, J; Halpern, BS; Mellinghoff, IK; Phelps, ME; Rozengurt, N; Safaei, A; Satyamurthy, N; Sawyers, CL; Silverman, DH; Stout, D; Tran, C; Waldherr, C; Weber, WA	1
Fujimoto, E; Fukumoto, K; Hagiwara, H; Hagiwara, K; Negishi, E; Sato, H; Shirai, S; Ueno, K; Yamasaki, H; Yano, T	1
Berlin, JD; Lockhart, AC; Lockhart, C	1
Alberta, JA; Guertin, AD; Kim, HA; Mak, KS; Zhang, DP	1
Rabindran, SK	1
Ganti, AK; Potti, A	1
Bucana, C; de Heus, G; Dumez, H; Eskens, FA; Fidler, IJ; Hoekstra, R; Planting, AS; Ravera, C; Sizer, KC; Vaidyanathan, S; van der Gaast, A; van Oosterom, AT; Verweij, J	1
Cheng, H; Fan, D; Feng, J; Fidler, IJ; Langley, RR; Tsan, R; Wu, Q; Wu, W	1
Franklin, RJ; Zhao, C	1
Ohnishi, M; Rambukkana, A; Tapinos, N	1
Forsberg, S; Ostman, A; Rollman, O	1
Bar-Eli, M; Fan, D; Fidler, IJ; Kerbel, RS; Kim, SJ; Kuwai, T; Nakamura, T; Sasaki, T; Villares, GJ; Wang, H; Zigler, M	1
Bos, EM; Henning, RH; Kloosterhuis, NJ; Leuvenink, HG; Melenhorst, WB; Mulder, GM; Nijboer, WN; Ploeg, RJ; Sandovici, M; Seelen, MA; Sunnarborg, SW; Trzpis, M; van Goor, H; Visser, L	1
Carter, BD; Limpert, AS	1
Advani, A; Cox, AJ; Gilbert, RE; Kelly, DJ; Wiggins, KJ; Zhang, Y	1
Bharti, R; Das, S; Dey, KK; Maiti, S; MaitiChoudhury, S; Mandal, M	1
Buikema, H; Duin, M; Duman-Dalkilic, B; Goris, M; Gurdal, H; Henning, RH; Landheer, SW; Mulder, GM; Ulu, N; van Dokkum, RP; van Goor, H; Vavrinec, P	1
Behera, R; Mensa-Wilmot, K; Thomas, SM	1
Han, SH; Kang, HY; Kang, SW; Kim, CH; Kim, S; Lee, MJ; Lee, SH; Moon, SJ; Nam, BY; Oh, HJ; Paeng, J; Park, JT; Yoo, TH	1

Reviews

9 review(s) available for pyrroles and pki 166

Article	Year
Anticancer therapy targeting the erbB family of receptor tyrosine kinases. Seminars in oncology, 2001, Volume: 28, Issue:5 Suppl 16 Topics: Animals; Antibodies, Bispecific; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Breast Neoplasms; Cetuximab; Enzyme Inhibitors; ErbB Receptors; Erlotinib Hydrochloride; Gefitinib; Humans; Protein-Tyrosine Kinases; Pyrimidines; Pyrroles; Quinazolines; Receptor, ErbB-2; Trastuzumab	2001
HER-targeted tyrosine-kinase inhibitors. Oncology, 2002, Volume: 63 Suppl 1 Topics: Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Clinical Trials as Topic; Enzyme Inhibitors; ErbB Receptors; Erlotinib Hydrochloride; Female; Gefitinib; Head and Neck Neoplasms; Humans; Lung Neoplasms; Morpholines; Ovarian Neoplasms; Protein-Tyrosine Kinases; Pyrimidines; Pyrroles; Quinazolines; Receptor, ErbB-2	2002
Tyrosine kinases as targets in cancer therapy - successes and failures. Expert opinion on therapeutic targets, 2003, Volume: 7, Issue:2 Topics: Animals; Antineoplastic Agents; Clinical Trials as Topic; Drug Design; Drug Screening Assays, Antitumor; ErbB Receptors; Fusion Proteins, bcr-abl; Humans; Mice; Mice, Nude; Neoplasm Proteins; Neoplasms; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrimidines; Pyrroles; Receptor Protein-Tyrosine Kinases; Receptors, Vascular Endothelial Growth Factor; Treatment Outcome	2003
Developing inhibitors of the epidermal growth factor receptor for cancer treatment. Journal of the National Cancer Institute, 2003, Jun-18, Volume: 95, Issue:12 Topics: Aminoquinolines; Aniline Compounds; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Cetuximab; Clinical Trials as Topic; Drug Design; Drugs, Investigational; ErbB Receptors; Erlotinib Hydrochloride; Gefitinib; Gene Expression Regulation, Neoplastic; Humans; Morpholines; Neoplasms; Organic Chemicals; Panitumumab; Pyrimidines; Pyrroles; Quinazolines; Signal Transduction; Structure-Activity Relationship	2003
Clinical studies with non-iressa EGFR tyrosine kinase inhibitors. Lung cancer (Amsterdam, Netherlands), 2003, Volume: 41 Suppl 1 Topics: Aminoquinolines; Aniline Compounds; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Clinical Trials as Topic; ErbB Receptors; Erlotinib Hydrochloride; Humans; Lapatinib; Lung Neoplasms; Organic Chemicals; Protein-Tyrosine Kinases; Pyrimidines; Pyrroles; Quinazolines; Treatment Outcome	2003
[Targeting of epidermal growth factor receptor and applications in ORL cancer]. Bulletin du cancer, 2003, Volume: 90 Spec No Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Carcinoma, Squamous Cell; Cetuximab; ErbB Receptors; Erlotinib Hydrochloride; Gefitinib; Humans; Morpholines; Neoplasm Proteins; Otorhinolaryngologic Neoplasms; Protein-Tyrosine Kinases; Pyrimidines; Pyrroles; Quinazolines	2003
The epidermal growth factor receptor as a target for colorectal cancer therapy. Seminars in oncology, 2005, Volume: 32, Issue:1 Topics: Aminoquinolines; Aniline Compounds; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Cell Transformation, Neoplastic; Cetuximab; Colorectal Neoplasms; Disease Progression; ErbB Receptors; Erlotinib Hydrochloride; Gefitinib; Humans; Lapatinib; Organic Chemicals; Panitumumab; Prognosis; Pyrimidines; Pyrroles; Quinazolines; Signal Transduction	2005
Antitumor activity of HER-2 inhibitors. Cancer letters, 2005, Sep-08, Volume: 227, Issue:1 Topics: Animals; Antineoplastic Agents; Drug Resistance, Neoplasm; ErbB Receptors; Humans; Intracellular Signaling Peptides and Proteins; Lapatinib; Neoplasms; Pyrimidines; Pyrroles; Quinazolines; Receptor, ErbB-2	2005
Epidermal growth factor inhibition in solid tumours. Expert opinion on biological therapy, 2005, Volume: 5, Issue:9 Topics: Administration, Oral; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cetuximab; Colorectal Neoplasms; Drug Delivery Systems; Drug Evaluation, Preclinical; ErbB Receptors; Erlotinib Hydrochloride; Gefitinib; Humans; Lung Neoplasms; Panitumumab; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Quinazolines; Randomized Controlled Trials as Topic	2005

Trials

1 trial(s) available for pyrroles and pki 166

Article	Year
Phase I and pharmacologic study of PKI166, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with advanced solid malignancies. Clinical cancer research : an official journal of the American Association for Cancer Research, 2005, Oct-01, Volume: 11, Issue:19 Pt 1 Topics: Absorption; Adult; Aged; Antineoplastic Agents; Area Under Curve; Dose-Response Relationship, Drug; ErbB Receptors; Female; Follow-Up Studies; Humans; Male; Maximum Tolerated Dose; Middle Aged; Models, Chemical; Neoplasms; Protein-Tyrosine Kinases; Pyrimidines; Pyrroles; Software; Time Factors; Vascular Endothelial Growth Factor A	2005

Article

Year

Phase I and pharmacologic study of PKI166, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with advanced solid malignancies.

Clinical cancer research : an official journal of the American Association for Cancer Research, 2005, Oct-01, Volume: 11, Issue:19 Pt 1

Topics: Absorption; Adult; Aged; Antineoplastic Agents; Area Under Curve; Dose-Response Relationship, Drug; ErbB Receptors; Female; Follow-Up Studies; Humans; Male; Maximum Tolerated Dose; Middle Aged; Models, Chemical; Neoplasms; Protein-Tyrosine Kinases; Pyrimidines; Pyrroles; Software; Time Factors; Vascular Endothelial Growth Factor A

2005

Other Studies

38 other study(ies) available for pyrroles and pki 166

Article	Year
Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma. Cancer research, 2000, Jun-01, Volume: 60, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Deoxycytidine; Down-Regulation; Endothelium; ErbB Receptors; Fluorescent Antibody Technique; Gemcitabine; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Male; Mice; Mice, Nude; Neoplasm Transplantation; Pancreatic Neoplasms; Platelet Endothelial Cell Adhesion Molecule-1; Protein-Tyrosine Kinases; Pyrimidines; Pyrroles; Signal Transduction; Time Factors; Tumor Cells, Cultured	2000
Optimization for the blockade of epidermal growth factor receptor signaling for therapy of human pancreatic carcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research, 2001, Volume: 7, Issue:8 Topics: Administration, Oral; Animals; Antineoplastic Agents; Cell Division; Deoxycytidine; Drug Administration Schedule; Drug Therapy, Combination; Endothelial Growth Factors; Enzyme Inhibitors; ErbB Receptors; Gemcitabine; Humans; Immunohistochemistry; Interleukin-8; Lymphokines; Male; Mice; Mice, Nude; Neoplasm Metastasis; Pancreatic Neoplasms; Phosphorylation; Platelet Endothelial Cell Adhesion Molecule-1; Proliferating Cell Nuclear Antigen; Pyrimidines; Pyrroles; Ribonucleotide Reductases; Signal Transduction; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Xenograft Model Antitumor Assays	2001
Mammary glands reconstituted with Neu/ErbB2 transformed HC11 cells provide a novel orthotopic tumor model for testing anti-cancer agents. Oncogene, 2001, Sep-06, Volume: 20, Issue:39 Topics: Animals; Antineoplastic Agents; Cell Division; Cell Line, Transformed; Cell Transformation, Neoplastic; Drug Screening Assays, Antitumor; ErbB Receptors; Female; Genes, erbB-2; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Paclitaxel; Pyrimidines; Pyrroles; Receptor, ErbB-2	2001
Blockade of vascular endothelial growth factor receptor and epidermal growth factor receptor signaling for therapy of metastatic human pancreatic cancer. Cancer research, 2002, Apr-01, Volume: 62, Issue:7 Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Division; Deoxycytidine; Endothelium, Vascular; ErbB Receptors; Gemcitabine; Humans; Immunohistochemistry; Male; Mice; Mice, Nude; Neoplasm Metastasis; Neovascularization, Pathologic; Pancreatic Neoplasms; Phthalazines; Pyridines; Pyrimidines; Pyrroles; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Xenograft Model Antitumor Assays	2002
The efficacy of ErbB receptor-targeted anticancer therapeutics is influenced by the availability of epidermal growth factor-related peptides. Cancer research, 2002, Jun-01, Volume: 62, Issue:11 Topics: Antibodies, Monoclonal; Antineoplastic Agents; Betacellulin; Breast Neoplasms; Cell Division; Drug Interactions; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; G1 Phase; Growth Substances; Humans; Intercellular Signaling Peptides and Proteins; Ligands; Neuregulin-1; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyrimidines; Pyrroles; Receptor, ErbB-2; Signal Transduction; Stomach Neoplasms; Substrate Specificity; Tumor Cells, Cultured	2002
Blockade of epidermal growth factor receptor signaling on tumor cells and tumor-associated endothelial cells for therapy of human carcinomas. The American journal of pathology, 2002, Volume: 161, Issue:3 Topics: Animals; Antineoplastic Agents; Deoxycytidine; Endothelium, Vascular; ErbB Receptors; Gemcitabine; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Neovascularization, Pathologic; Paclitaxel; Pyrimidines; Pyrroles; Signal Transduction; Tumor Cells, Cultured	2002
Growth inhibitory effects of the dual ErbB1/ErbB2 tyrosine kinase inhibitor PKI-166 on human prostate cancer xenografts. Cancer research, 2002, Sep-15, Volume: 62, Issue:18 Topics: Androgens; Animals; Cell Division; ErbB Receptors; Growth Inhibitors; Humans; Male; Mice; Mice, SCID; Prostatic Neoplasms; Pyrimidines; Pyrroles; Receptor, ErbB-2; Signal Transduction; Tumor Cells, Cultured; Xenograft Model Antitumor Assays	2002
Blockade of the epidermal growth factor receptor signaling inhibits angiogenesis leading to regression of human renal cell carcinoma growing orthotopically in nude mice. Clinical cancer research : an official journal of the American Association for Cancer Research, 2002, Volume: 8, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Carcinoma, Renal Cell; Deoxycytidine; DNA-Binding Proteins; Down-Regulation; Endothelial Growth Factors; Enzyme Inhibitors; ErbB Receptors; Gemcitabine; Immunohistochemistry; In Situ Nick-End Labeling; Intercellular Signaling Peptides and Proteins; Kidney; Lung; Lymphokines; Mice; Mice, Nude; Neoplasm Metastasis; Neovascularization, Pathologic; Phosphorylation; Proliferating Cell Nuclear Antigen; Protein-Tyrosine Kinases; Pyrimidines; Pyrroles; Signal Transduction; STAT3 Transcription Factor; Time Factors; Trans-Activators; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors	2002
Blockade of epidermal growth factor receptor signaling in tumor cells and tumor-associated endothelial cells for therapy of androgen-independent human prostate cancer growing in the bone of nude mice. Clinical cancer research : an official journal of the American Association for Cancer Research, 2003, Volume: 9, Issue:3 Topics: Administration, Oral; Animals; Antineoplastic Agents, Phytogenic; Blotting, Western; Bone and Bones; Bone Neoplasms; Dose-Response Relationship, Drug; Endothelial Growth Factors; Endothelium, Vascular; ErbB Receptors; Fibroblast Growth Factor 2; Immunohistochemistry; In Situ Nick-End Labeling; Intercellular Signaling Peptides and Proteins; Interleukin-8; Lymphokines; Male; Mice; Mice, Nude; Microscopy, Fluorescence; Neoplasm Metastasis; Neoplasm Transplantation; Paclitaxel; Phosphorylation; Platelet Endothelial Cell Adhesion Molecule-1; Proliferating Cell Nuclear Antigen; Prostatic Neoplasms; Pyrimidines; Pyrroles; Signal Transduction; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors	2003
Blockade of epidermal growth factor receptor signaling leads to inhibition of renal cell carcinoma growth in the bone of nude mice. Cancer research, 2003, Jun-01, Volume: 63, Issue:11 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Bone Neoplasms; Carcinoma, Renal Cell; Cell Division; Epidermal Growth Factor; ErbB Receptors; Humans; Kidney Neoplasms; Male; Mice; Mice, Nude; Paclitaxel; Phosphorylation; Pyrimidines; Pyrroles; Recombinant Proteins; Signal Transduction; Transforming Growth Factor alpha; Tumor Cells, Cultured; Xenograft Model Antitumor Assays	2003
Epidermal growth factor receptor blockade potentiates apoptosis mediated by Paclitaxel and leads to prolonged survival in a murine model of oral cancer. Clinical cancer research : an official journal of the American Association for Cancer Research, 2003, Aug-01, Volume: 9, Issue:8 Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Cell Death; Cell Line, Tumor; Dose-Response Relationship, Drug; ErbB Receptors; Head and Neck Neoplasms; Humans; In Situ Nick-End Labeling; Ligands; Male; Mice; Mice, Nude; Microscopy, Fluorescence; Mouth Neoplasms; Neoplasms; Paclitaxel; Phosphorylation; Propidium; Pyrimidines; Pyrroles; Tongue; Tongue Neoplasms; Tyrosine	2003
Inhibition of zebrafish epidermal growth factor receptor activity results in cardiovascular defects. Mechanisms of development, 2003, Volume: 120, Issue:7 Topics: Amino Acid Sequence; Animals; Cardiovascular Abnormalities; ErbB Receptors; Humans; Molecular Sequence Data; Pyrimidines; Pyrroles; Quinazolines; Rats; Tyrphostins; Zebrafish	2003
Renal cell carcinoma bone metastasis: epidermal growth factor receptor targeting. Clinical orthopaedics and related research, 2003, Issue:415 Suppl Topics: Animals; Antineoplastic Agents, Phytogenic; Bone Neoplasms; Carcinoma, Renal Cell; ErbB Receptors; Kidney Neoplasms; Mice; Mice, Nude; Paclitaxel; Phosphorylation; Pyrimidines; Pyrroles; Tumor Cells, Cultured	2003
Bioassay using epidermal keratinocytes to determine phosphorylation status of the epidermal growth factor receptor in distant neoplasms. International journal of oncology, 2004, Volume: 24, Issue:1 Topics: Animals; Benzimidazoles; Biological Assay; Cell Line, Tumor; Dose-Response Relationship, Drug; Endocytosis; Epidermal Growth Factor; ErbB Receptors; Fibrosarcoma; Keratinocytes; Mice; Mice, Inbred C3H; Microscopy, Fluorescence; Neoplasm Transplantation; Phosphorylation; Pyrimidines; Pyrroles; Specific Pathogen-Free Organisms	2004
Novel radiosensitizers for locally advanced epithelial tumors: inhibition of the PI3K/Akt survival pathway in tumor cells and in tumor-associated endothelial cells as a novel treatment strategy? International journal of radiation oncology, biology, physics, 2004, Feb-01, Volume: 58, Issue:2 Topics: Cell Survival; Combined Modality Therapy; Down-Regulation; Endothelial Cells; Enzyme Inhibitors; ErbB Receptors; Neoplasm Proteins; Neoplasms, Glandular and Epithelial; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phthalazines; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; Pyrimidines; Pyrroles; Radiation-Sensitizing Agents; Receptors, Vascular Endothelial Growth Factor; Staurosporine	2004
Hypoxia increases resistance of human pancreatic cancer cells to apoptosis induced by gemcitabine. Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Apr-01, Volume: 10, Issue:7 Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Apoptosis; Blotting, Western; Butadienes; Cell Division; Cell Line, Tumor; Chromones; Deoxycytidine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Gemcitabine; Humans; Hypoxia; Mitogen-Activated Protein Kinases; Morpholines; Neovascularization, Pathologic; NF-kappa B; Nitriles; Oxygen; Pancreatic Neoplasms; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein-Tyrosine Kinases; Pyrimidines; Pyrroles; Signal Transduction; Sp1 Transcription Factor; Time Factors; Tyrosine	2004
Simultaneous blockade of platelet-derived growth factor-receptor and epidermal growth factor-receptor signaling and systemic administration of paclitaxel as therapy for human prostate cancer metastasis in bone of nude mice. Cancer research, 2004, Jun-15, Volume: 64, Issue:12 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzamides; Bone Neoplasms; Cell Division; Enzyme Inhibitors; ErbB Receptors; Humans; Imatinib Mesylate; In Situ Nick-End Labeling; Male; Mice; Mice, Nude; Paclitaxel; Phosphorylation; Piperazines; Platelet Endothelial Cell Adhesion Molecule-1; Prostatic Neoplasms; Pyrimidines; Pyrroles; Receptors, Platelet-Derived Growth Factor; Substrate Specificity; Xenograft Model Antitumor Assays	2004
Epidermal growth factor receptor inhibition promotes desmosome assembly and strengthens intercellular adhesion in squamous cell carcinoma cells. The Journal of biological chemistry, 2004, Aug-27, Volume: 279, Issue:35 Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Cadherins; Calcium; Carcinoma, Squamous Cell; Cell Adhesion; Cell Communication; Cell Line, Tumor; Cetuximab; Culture Media, Conditioned; Cytoskeletal Proteins; Desmocollins; Desmoglein 2; Desmogleins; Desmoplakins; Desmosomes; Dose-Response Relationship, Drug; ErbB Receptors; gamma Catenin; Humans; Immunoblotting; Microscopy, Phase-Contrast; Mouth Neoplasms; Phenotype; Phosphorylation; Precipitin Tests; Pyrimidines; Pyrroles; Subcellular Fractions; Tyrosine	2004
Relationship between antiapoptotic molecules and metastatic potency and the involvement of DNA-dependent protein kinase in the chemosensitization of metastatic human cancer cells by epidermal growth factor receptor blockade. The Journal of pharmacology and experimental therapeutics, 2004, Volume: 311, Issue:3 Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Cell Line, Tumor; DNA-Activated Protein Kinase; DNA-Binding Proteins; Drug Synergism; Electrophoretic Mobility Shift Assay; ErbB Receptors; Etoposide; Genes, MDR; Humans; Indicators and Reagents; Melanoma; Neoplasm Metastasis; Nuclear Proteins; Protein Serine-Threonine Kinases; Pyrimidines; Pyrroles; Radiation-Sensitizing Agents; Rats	2004
Hepatic transport of PKI166, an epidermal growth factor receptor kinase inhibitor of the pyrrolo-pyrimidine class, and its main metabolite, ACU154. Drug metabolism and disposition: the biological fate of chemicals, 2004, Volume: 32, Issue:11 Topics: Animals; Biological Transport; Cell Line; Dogs; Dose-Response Relationship, Drug; Enzyme Inhibitors; ErbB Receptors; Liver; Pyrimidines; Pyrroles; Rats; Rats, Wistar	2004
Epidermal growth factor receptor inhibition attenuates early kidney enlargement in experimental diabetes. Kidney international, 2004, Volume: 66, Issue:5 Topics: Animals; Apoptosis; Bromodeoxyuridine; Cell Division; Cell Line; Diabetes Mellitus, Experimental; Epithelial Cells; ErbB Receptors; Glomerular Filtration Rate; Immunohistochemistry; Kidney; Kidney Glomerulus; Male; Organ Size; Proliferating Cell Nuclear Antigen; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley	2004
HER2/neu kinase-dependent modulation of androgen receptor function through effects on DNA binding and stability. Cancer cell, 2004, Volume: 6, Issue:5 Topics: Animals; Chlorocebus aethiops; COS Cells; DNA, Neoplasm; ErbB Receptors; Humans; Male; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyrimidines; Pyrroles; Receptor, ErbB-2; Receptors, Androgen; RNA, Small Interfering; Signal Transduction; Transfection; Tumor Cells, Cultured	2004
Epidermal growth factor receptor tyrosine kinase inhibitor does not improve paclitaxel effect in an orthotopic mouse model of lung cancer. Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Dec-15, Volume: 10, Issue:24 Topics: Adenocarcinoma, Bronchiolo-Alveolar; Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Non-Small-Cell Lung; Drug Therapy, Combination; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Fibroblast Growth Factor 2; Humans; Lung Neoplasms; Male; Mice; Mice, Nude; Mitogen-Activated Protein Kinases; Models, Animal; Paclitaxel; Phosphorylation; Pyrimidines; Pyrroles; Survival Rate	2004
Monitoring antiproliferative responses to kinase inhibitor therapy in mice with 3'-deoxy-3'-18F-fluorothymidine PET. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2005, Volume: 46, Issue:1 Topics: Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Dideoxynucleosides; Disease Models, Animal; Fluorodeoxyglucose F18; Humans; Mice; Mice, SCID; Neoplasm Invasiveness; Positron-Emission Tomography; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Radiopharmaceuticals; Treatment Outcome	2005
Cytotoxic effect of the Her-2/Her-1 inhibitor PKI-166 on renal cancer cells expressing the connexin 32 gene. Journal of pharmacological sciences, 2005, Volume: 97, Issue:2 Topics: Carcinoma, Renal Cell; Cell Line, Tumor; Connexins; Dose-Response Relationship, Drug; ErbB Receptors; Gap Junction beta-1 Protein; Genes, erbB-1; Growth Inhibitors; Humans; Kidney Neoplasms; Pyrimidines; Pyrroles; Receptor, ErbB-2	2005
Microanatomy of axon/glial signaling during Wallerian degeneration. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005, Mar-30, Volume: 25, Issue:13 Topics: Analysis of Variance; Animals; Axotomy; Blotting, Western; Bromodeoxyuridine; Cell Proliferation; Cells, Cultured; Coculture Techniques; Demyelinating Diseases; Disease Models, Animal; Embryo, Mammalian; Female; Fluorescent Antibody Technique; Ganglia, Spinal; Gene Expression; Glycoproteins; Immunoprecipitation; Mitogen-Activated Protein Kinase Kinases; Myelin Basic Protein; Myelin Sheath; Neuregulins; Neuroglia; Neurons; Platelet-Derived Growth Factor; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptor Protein-Tyrosine Kinases; Receptor, ErbB-2; Schwann Cells; Sciatic Neuropathy; Signal Transduction; Sodium Channels; Time Factors; Wallerian Degeneration	2005
Construction of a novel constitutively active chimeric EGFR to identify new targets for therapy. Neoplasia (New York, N.Y.), 2005, Volume: 7, Issue:12 Topics: Animals; Brain; CD3 Complex; Cell Proliferation; Cells, Cultured; Endothelium, Vascular; ErbB Receptors; Humans; Kidney; Ligands; Mice; Mitogen-Activated Protein Kinases; Phenotype; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyrimidines; Pyrroles; Receptors, Antigen, T-Cell; Recombinant Fusion Proteins; Signal Transduction; STAT3 Transcription Factor	2005
Tyrosine kinases: maiming myelin in leprosy. Nature medicine, 2006, Volume: 12, Issue:8 Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Butadienes; Cells, Cultured; Coculture Techniques; Enzyme Activation; Enzyme Inhibitors; Homeodomain Proteins; Humans; Leprosy; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Models, Biological; Mycobacterium leprae; Myelin Sheath; Neurons; Nitriles; Phosphorylation; Pyrimidines; Pyrroles; Receptor, ErbB-2; Schwann Cells; Trastuzumab	2006
ErbB2 receptor tyrosine kinase signaling mediates early demyelination induced by leprosy bacilli. Nature medicine, 2006, Volume: 12, Issue:8 Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Butadienes; Cells, Cultured; Chlorocebus aethiops; Coculture Techniques; COS Cells; Demyelinating Diseases; Enzyme Activation; Enzyme Inhibitors; HeLa Cells; Humans; Leprosy; Mice; Mice, Knockout; Mice, Nude; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mycobacterium leprae; Nitriles; Pyrimidines; Pyrroles; Rats; Receptor, ErbB-2; Schwann Cells; Sciatic Nerve; Signal Transduction; Trastuzumab	2006
Regeneration of human epidermis on acellular dermis is impeded by small-molecule inhibitors of EGF receptor tyrosine kinase. Archives of dermatological research, 2008, Volume: 300, Issue:9 Topics: Cell Proliferation; Cells, Cultured; Dermis; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; Epidermis; ErbB Receptors; Humans; Keratinocytes; Models, Biological; Organ Culture Techniques; Protein-Tyrosine Kinases; Psoriasis; Pyrimidines; Pyrroles; Receptor, ErbB-2; Regeneration	2008
Phosphorylated epidermal growth factor receptor on tumor-associated endothelial cells is a primary target for therapy with tyrosine kinase inhibitors. Neoplasia (New York, N.Y.), 2008, Volume: 10, Issue:5 Topics: Animals; Apoptosis; Blotting, Western; Camptothecin; Cecum; Cell Proliferation; Colonic Neoplasms; Drug Therapy, Combination; Endothelial Cells; Enzyme Inhibitors; ErbB Receptors; Humans; Immunoenzyme Techniques; In Situ Nick-End Labeling; Irinotecan; Lymphatic Metastasis; Male; Mice; Mice, Nude; Necrosis; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrimidines; Pyrroles; Receptor, ErbB-2; RNA, Small Interfering; Topoisomerase I Inhibitors; Transforming Growth Factor alpha	2008
Heparin binding epidermal growth factor in renal ischaemia/reperfusion injury. The Journal of pathology, 2010, Volume: 221, Issue:2 Topics: Adult; Aged; Animals; Cells, Cultured; Disease Models, Animal; Epidermal Growth Factor; Female; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Kidney; Kidney Transplantation; Male; Mice; Middle Aged; Pyrimidines; Pyrroles; Rats; Rats, Wistar; Reperfusion Injury; RNA, Messenger; Up-Regulation; Young Adult	2010
Axonal neuregulin 1 type III activates NF-kappaB in Schwann cells during myelin formation. The Journal of biological chemistry, 2010, May-28, Volume: 285, Issue:22 Topics: Animals; Axons; Chlorocebus aethiops; Colforsin; COS Cells; Gene Deletion; Mice; Models, Biological; Myelin Sheath; Neuregulin-1; NF-kappa B; Protein Isoforms; Protein Structure, Tertiary; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Schwann Cells; Signal Transduction	2010
Inhibition of the epidermal growth factor receptor preserves podocytes and attenuates albuminuria in experimental diabetic nephropathy. Nephrology (Carlton, Vic.), 2011, Volume: 16, Issue:6 Topics: Albuminuria; Animals; Biomarkers; Diabetes Mellitus, Experimental; Diabetic Nephropathies; ErbB Receptors; Female; Hypertrophy; Kidney; Mice; Podocytes; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Rats; Rats, Transgenic; Renin; WT1 Proteins	2011
PKI 166 induced redox signalling and apoptosis through activation of p53, MAP kinase and caspase pathway in epidermoid carcinoma. Journal of experimental therapeutics & oncology, 2012, Volume: 10, Issue:2 Topics: Apoptosis; Blotting, Western; Carcinoma, Squamous Cell; Caspases; Catalase; Cell Cycle; Cell Proliferation; Cytochromes c; ErbB Receptors; Humans; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Mitochondria; Mitogen-Activated Protein Kinases; Oxidation-Reduction; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Pyrimidines; Pyrroles; Reactive Oxygen Species; Signal Transduction; Superoxide Dismutase; Tumor Cells, Cultured; Tumor Suppressor Protein p53	2012
Epidermal growth factor receptor inhibitor PKI-166 governs cardiovascular protection without beneficial effects on the kidney in hypertensive 5/6 nephrectomized rats. The Journal of pharmacology and experimental therapeutics, 2013, Volume: 345, Issue:3 Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta, Thoracic; Blood Pressure; Cardiotonic Agents; ErbB Receptors; Hypertension, Renal; Immunohistochemistry; Kidney; Lisinopril; Male; Mesenteric Arteries; Muscle Contraction; Muscle Tonus; Muscle, Smooth, Vascular; Nephrectomy; Proteinuria; Pyrimidines; Pyrroles; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptors, Adrenergic, alpha-1	2013
New chemical scaffolds for human african trypanosomiasis lead discovery from a screen of tyrosine kinase inhibitor drugs. Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:4 Topics: Animals; Axitinib; Benzamides; Erlotinib Hydrochloride; Female; HeLa Cells; Humans; Imatinib Mesylate; Imidazoles; Indazoles; Indoles; Lapatinib; Mice; Morpholines; Piperazines; Protein Kinase Inhibitors; Purines; Pyrimidines; Pyrroles; Quinazolines; Sunitinib; Trypanosomiasis, African	2014
Podocyte hypertrophy precedes apoptosis under experimental diabetic conditions. Apoptosis : an international journal on programmed cell death, 2015, Volume: 20, Issue:8 Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Aspartic Acid; Caspase 3; Caspase Inhibitors; Cells, Cultured; Diabetes Mellitus, Experimental; ErbB Receptors; Gene Expression; Hypertrophy; Kidney Glomerulus; Male; Mice; Podocytes; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Rats, Sprague-Dawley; Streptozocin	2015