pyrroles and pki 166
pyrroles has been researched along with pki 166 in 48 studies
Research
Studies (48)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 41 (85.42) | 29.6817 |
| 2010's | 7 (14.58) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Abbruzzese, J; Bruns, CJ; Buchdunger, E; Fan, D; Fidler, IJ; Harbison, MT; Ozawa, S; Radinsky, R; Solorzano, CC; Traxler, P; Tsan, R | 1 |
| Baker, CH; Buchdunger, E; Cohen, P; Fidler, IJ; Killion, JJ; Solorzano, CC; Traxler, P; Tsan, R | 1 |
| Brandt, R; Hynes, NE; Wong, AM | 1 |
| Fry, DW; Slichenmyer, WJ | 1 |
| Baker, CH; Fidler, IJ; Solorzano, CC | 1 |
| Hynes, NE; Lane, HA; Motoyama, AB | 1 |
| Baker, CH; Bucana, CD; Fidler, IJ; Kedar, D; McCarty, MF; Tsan, R; Weber, KL | 1 |
| Mellinghoff, IK; Sawyers, CL; Tran, C | 1 |
| Baselga, J; Hammond, LA | 1 |
| Baker, CH; Dinney, CP; Fidler, IJ; Kedar, D; Killion, JJ | 1 |
| Fidler, IJ; Karashima, T; Killion, JJ; Kim, SJ; Shepherd, DL; Uehara, H | 1 |
| Traxler, P | 1 |
| Baker, C; Doucet, M; Fidler, IJ; Kim, SJ; Price, JE; Weber, KL | 1 |
| Grünwald, V; Hidalgo, M | 1 |
| Bonomi, P | 1 |
| Bekele, BN; Bucana, CD; Doan, DD; Fidler, IJ; Greenberg, JS; Holsinger, FC; Jasser, SA; Myers, JN; Schiff, BA; Swan, EA; Younes, MN | 1 |
| Davidson, AJ; Goishi, K; Klagsbrun, M; Lee, P; Nishi, E; Zon, LI | 1 |
| Doucet, M; Price, JE; Weber, KL | 1 |
| Bucana, CD; Fidler, IJ | 1 |
| Bodis, S; Hofstetter, B; Pruschy, M; Riesterer, O; Tenzer, A; Vuong, V; Zingg, D | 1 |
| Aunoble, B; Bourhis, J; Rolhion, C; Tortochaux, J | 1 |
| Fidler, IJ; Yokoi, K | 1 |
| Fan, D; Fidler, IJ; He, J; Killion, JJ; Kim, SJ; Langley, RR; Tsan, R; Uehara, H; Yazici, S | 1 |
| Getsios, S; Green, KJ; Klessner, J; Lorch, JH; Park, JK; Stack, MS; Wu, YL | 1 |
| Bae, JH; Chung, BS; Ju, DS; Kang, CD; Kim, DW; Kim, MJ; Kim, SH; Kwon, JK; Um, JH | 1 |
| Gross, G; Kretz, O; Sugiyama, Y; Takada, T; Weiss, HM | 1 |
| Gilbert, RE; Kelly, DJ; Wassef, L | 1 |
| Kwon, A; Mellinghoff, IK; Sawyers, CL; Tran, C; Vivanco, I; Wongvipat, J | 1 |
| Fidler, IJ; Herbst, RS; Isobe, T; Itasaka, S; Kenji, Y; O'reilly, MS; Onn, A; Shibuya, K; Shintani, T; Wu, W | 1 |
| Barrio, J; Czernin, J; Halpern, BS; Mellinghoff, IK; Phelps, ME; Rozengurt, N; Safaei, A; Satyamurthy, N; Sawyers, CL; Silverman, DH; Stout, D; Tran, C; Waldherr, C; Weber, WA | 1 |
| Fujimoto, E; Fukumoto, K; Hagiwara, H; Hagiwara, K; Negishi, E; Sato, H; Shirai, S; Ueno, K; Yamasaki, H; Yano, T | 1 |
| Berlin, JD; Lockhart, AC; Lockhart, C | 1 |
| Alberta, JA; Guertin, AD; Kim, HA; Mak, KS; Zhang, DP | 1 |
| Rabindran, SK | 1 |
| Ganti, AK; Potti, A | 1 |
| Bucana, C; de Heus, G; Dumez, H; Eskens, FA; Fidler, IJ; Hoekstra, R; Planting, AS; Ravera, C; Sizer, KC; Vaidyanathan, S; van der Gaast, A; van Oosterom, AT; Verweij, J | 1 |
| Cheng, H; Fan, D; Feng, J; Fidler, IJ; Langley, RR; Tsan, R; Wu, Q; Wu, W | 1 |
| Franklin, RJ; Zhao, C | 1 |
| Ohnishi, M; Rambukkana, A; Tapinos, N | 1 |
| Forsberg, S; Ostman, A; Rollman, O | 1 |
| Bar-Eli, M; Fan, D; Fidler, IJ; Kerbel, RS; Kim, SJ; Kuwai, T; Nakamura, T; Sasaki, T; Villares, GJ; Wang, H; Zigler, M | 1 |
| Bos, EM; Henning, RH; Kloosterhuis, NJ; Leuvenink, HG; Melenhorst, WB; Mulder, GM; Nijboer, WN; Ploeg, RJ; Sandovici, M; Seelen, MA; Sunnarborg, SW; Trzpis, M; van Goor, H; Visser, L | 1 |
| Carter, BD; Limpert, AS | 1 |
| Advani, A; Cox, AJ; Gilbert, RE; Kelly, DJ; Wiggins, KJ; Zhang, Y | 1 |
| Bharti, R; Das, S; Dey, KK; Maiti, S; MaitiChoudhury, S; Mandal, M | 1 |
| Buikema, H; Duin, M; Duman-Dalkilic, B; Goris, M; Gurdal, H; Henning, RH; Landheer, SW; Mulder, GM; Ulu, N; van Dokkum, RP; van Goor, H; Vavrinec, P | 1 |
| Behera, R; Mensa-Wilmot, K; Thomas, SM | 1 |
| Han, SH; Kang, HY; Kang, SW; Kim, CH; Kim, S; Lee, MJ; Lee, SH; Moon, SJ; Nam, BY; Oh, HJ; Paeng, J; Park, JT; Yoo, TH | 1 |
Reviews
9 review(s) available for pyrroles and pki 166
| Article | Year |
|---|---|
Anticancer therapy targeting the erbB family of receptor tyrosine kinases.
Topics: Animals; Antibodies, Bispecific; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Breast Neoplasms; Cetuximab; Enzyme Inhibitors; ErbB Receptors; Erlotinib Hydrochloride; Gefitinib; Humans; Protein-Tyrosine Kinases; Pyrimidines; Pyrroles; Quinazolines; Receptor, ErbB-2; Trastuzumab | 2001 |
HER-targeted tyrosine-kinase inhibitors.
Topics: Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Clinical Trials as Topic; Enzyme Inhibitors; ErbB Receptors; Erlotinib Hydrochloride; Female; Gefitinib; Head and Neck Neoplasms; Humans; Lung Neoplasms; Morpholines; Ovarian Neoplasms; Protein-Tyrosine Kinases; Pyrimidines; Pyrroles; Quinazolines; Receptor, ErbB-2 | 2002 |
Tyrosine kinases as targets in cancer therapy - successes and failures.
Topics: Animals; Antineoplastic Agents; Clinical Trials as Topic; Drug Design; Drug Screening Assays, Antitumor; ErbB Receptors; Fusion Proteins, bcr-abl; Humans; Mice; Mice, Nude; Neoplasm Proteins; Neoplasms; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrimidines; Pyrroles; Receptor Protein-Tyrosine Kinases; Receptors, Vascular Endothelial Growth Factor; Treatment Outcome | 2003 |
Developing inhibitors of the epidermal growth factor receptor for cancer treatment.
Topics: Aminoquinolines; Aniline Compounds; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Cetuximab; Clinical Trials as Topic; Drug Design; Drugs, Investigational; ErbB Receptors; Erlotinib Hydrochloride; Gefitinib; Gene Expression Regulation, Neoplastic; Humans; Morpholines; Neoplasms; Organic Chemicals; Panitumumab; Pyrimidines; Pyrroles; Quinazolines; Signal Transduction; Structure-Activity Relationship | 2003 |
Clinical studies with non-iressa EGFR tyrosine kinase inhibitors.
Topics: Aminoquinolines; Aniline Compounds; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Clinical Trials as Topic; ErbB Receptors; Erlotinib Hydrochloride; Humans; Lapatinib; Lung Neoplasms; Organic Chemicals; Protein-Tyrosine Kinases; Pyrimidines; Pyrroles; Quinazolines; Treatment Outcome | 2003 |
[Targeting of epidermal growth factor receptor and applications in ORL cancer].
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Carcinoma, Squamous Cell; Cetuximab; ErbB Receptors; Erlotinib Hydrochloride; Gefitinib; Humans; Morpholines; Neoplasm Proteins; Otorhinolaryngologic Neoplasms; Protein-Tyrosine Kinases; Pyrimidines; Pyrroles; Quinazolines | 2003 |
The epidermal growth factor receptor as a target for colorectal cancer therapy.
Topics: Aminoquinolines; Aniline Compounds; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Cell Transformation, Neoplastic; Cetuximab; Colorectal Neoplasms; Disease Progression; ErbB Receptors; Erlotinib Hydrochloride; Gefitinib; Humans; Lapatinib; Organic Chemicals; Panitumumab; Prognosis; Pyrimidines; Pyrroles; Quinazolines; Signal Transduction | 2005 |
Antitumor activity of HER-2 inhibitors.
Topics: Animals; Antineoplastic Agents; Drug Resistance, Neoplasm; ErbB Receptors; Humans; Intracellular Signaling Peptides and Proteins; Lapatinib; Neoplasms; Pyrimidines; Pyrroles; Quinazolines; Receptor, ErbB-2 | 2005 |
Epidermal growth factor inhibition in solid tumours.
Topics: Administration, Oral; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cetuximab; Colorectal Neoplasms; Drug Delivery Systems; Drug Evaluation, Preclinical; ErbB Receptors; Erlotinib Hydrochloride; Gefitinib; Humans; Lung Neoplasms; Panitumumab; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Quinazolines; Randomized Controlled Trials as Topic | 2005 |
Trials
1 trial(s) available for pyrroles and pki 166
| Article | Year |
|---|---|
Phase I and pharmacologic study of PKI166, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with advanced solid malignancies.
Topics: Absorption; Adult; Aged; Antineoplastic Agents; Area Under Curve; Dose-Response Relationship, Drug; ErbB Receptors; Female; Follow-Up Studies; Humans; Male; Maximum Tolerated Dose; Middle Aged; Models, Chemical; Neoplasms; Protein-Tyrosine Kinases; Pyrimidines; Pyrroles; Software; Time Factors; Vascular Endothelial Growth Factor A | 2005 |
Other Studies
38 other study(ies) available for pyrroles and pki 166
| Article | Year |
|---|---|
Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma.
Topics: Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Deoxycytidine; Down-Regulation; Endothelium; ErbB Receptors; Fluorescent Antibody Technique; Gemcitabine; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Male; Mice; Mice, Nude; Neoplasm Transplantation; Pancreatic Neoplasms; Platelet Endothelial Cell Adhesion Molecule-1; Protein-Tyrosine Kinases; Pyrimidines; Pyrroles; Signal Transduction; Time Factors; Tumor Cells, Cultured | 2000 |
Optimization for the blockade of epidermal growth factor receptor signaling for therapy of human pancreatic carcinoma.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Cell Division; Deoxycytidine; Drug Administration Schedule; Drug Therapy, Combination; Endothelial Growth Factors; Enzyme Inhibitors; ErbB Receptors; Gemcitabine; Humans; Immunohistochemistry; Interleukin-8; Lymphokines; Male; Mice; Mice, Nude; Neoplasm Metastasis; Pancreatic Neoplasms; Phosphorylation; Platelet Endothelial Cell Adhesion Molecule-1; Proliferating Cell Nuclear Antigen; Pyrimidines; Pyrroles; Ribonucleotide Reductases; Signal Transduction; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Xenograft Model Antitumor Assays | 2001 |
Mammary glands reconstituted with Neu/ErbB2 transformed HC11 cells provide a novel orthotopic tumor model for testing anti-cancer agents.
Topics: Animals; Antineoplastic Agents; Cell Division; Cell Line, Transformed; Cell Transformation, Neoplastic; Drug Screening Assays, Antitumor; ErbB Receptors; Female; Genes, erbB-2; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Paclitaxel; Pyrimidines; Pyrroles; Receptor, ErbB-2 | 2001 |
Blockade of vascular endothelial growth factor receptor and epidermal growth factor receptor signaling for therapy of metastatic human pancreatic cancer.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Division; Deoxycytidine; Endothelium, Vascular; ErbB Receptors; Gemcitabine; Humans; Immunohistochemistry; Male; Mice; Mice, Nude; Neoplasm Metastasis; Neovascularization, Pathologic; Pancreatic Neoplasms; Phthalazines; Pyridines; Pyrimidines; Pyrroles; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Xenograft Model Antitumor Assays | 2002 |
The efficacy of ErbB receptor-targeted anticancer therapeutics is influenced by the availability of epidermal growth factor-related peptides.
Topics: Antibodies, Monoclonal; Antineoplastic Agents; Betacellulin; Breast Neoplasms; Cell Division; Drug Interactions; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; G1 Phase; Growth Substances; Humans; Intercellular Signaling Peptides and Proteins; Ligands; Neuregulin-1; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyrimidines; Pyrroles; Receptor, ErbB-2; Signal Transduction; Stomach Neoplasms; Substrate Specificity; Tumor Cells, Cultured | 2002 |
Blockade of epidermal growth factor receptor signaling on tumor cells and tumor-associated endothelial cells for therapy of human carcinomas.
Topics: Animals; Antineoplastic Agents; Deoxycytidine; Endothelium, Vascular; ErbB Receptors; Gemcitabine; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Neovascularization, Pathologic; Paclitaxel; Pyrimidines; Pyrroles; Signal Transduction; Tumor Cells, Cultured | 2002 |
Growth inhibitory effects of the dual ErbB1/ErbB2 tyrosine kinase inhibitor PKI-166 on human prostate cancer xenografts.
Topics: Androgens; Animals; Cell Division; ErbB Receptors; Growth Inhibitors; Humans; Male; Mice; Mice, SCID; Prostatic Neoplasms; Pyrimidines; Pyrroles; Receptor, ErbB-2; Signal Transduction; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2002 |
Blockade of the epidermal growth factor receptor signaling inhibits angiogenesis leading to regression of human renal cell carcinoma growing orthotopically in nude mice.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Carcinoma, Renal Cell; Deoxycytidine; DNA-Binding Proteins; Down-Regulation; Endothelial Growth Factors; Enzyme Inhibitors; ErbB Receptors; Gemcitabine; Immunohistochemistry; In Situ Nick-End Labeling; Intercellular Signaling Peptides and Proteins; Kidney; Lung; Lymphokines; Mice; Mice, Nude; Neoplasm Metastasis; Neovascularization, Pathologic; Phosphorylation; Proliferating Cell Nuclear Antigen; Protein-Tyrosine Kinases; Pyrimidines; Pyrroles; Signal Transduction; STAT3 Transcription Factor; Time Factors; Trans-Activators; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2002 |
Blockade of epidermal growth factor receptor signaling in tumor cells and tumor-associated endothelial cells for therapy of androgen-independent human prostate cancer growing in the bone of nude mice.
Topics: Administration, Oral; Animals; Antineoplastic Agents, Phytogenic; Blotting, Western; Bone and Bones; Bone Neoplasms; Dose-Response Relationship, Drug; Endothelial Growth Factors; Endothelium, Vascular; ErbB Receptors; Fibroblast Growth Factor 2; Immunohistochemistry; In Situ Nick-End Labeling; Intercellular Signaling Peptides and Proteins; Interleukin-8; Lymphokines; Male; Mice; Mice, Nude; Microscopy, Fluorescence; Neoplasm Metastasis; Neoplasm Transplantation; Paclitaxel; Phosphorylation; Platelet Endothelial Cell Adhesion Molecule-1; Proliferating Cell Nuclear Antigen; Prostatic Neoplasms; Pyrimidines; Pyrroles; Signal Transduction; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2003 |
Blockade of epidermal growth factor receptor signaling leads to inhibition of renal cell carcinoma growth in the bone of nude mice.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Bone Neoplasms; Carcinoma, Renal Cell; Cell Division; Epidermal Growth Factor; ErbB Receptors; Humans; Kidney Neoplasms; Male; Mice; Mice, Nude; Paclitaxel; Phosphorylation; Pyrimidines; Pyrroles; Recombinant Proteins; Signal Transduction; Transforming Growth Factor alpha; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2003 |
Epidermal growth factor receptor blockade potentiates apoptosis mediated by Paclitaxel and leads to prolonged survival in a murine model of oral cancer.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Cell Death; Cell Line, Tumor; Dose-Response Relationship, Drug; ErbB Receptors; Head and Neck Neoplasms; Humans; In Situ Nick-End Labeling; Ligands; Male; Mice; Mice, Nude; Microscopy, Fluorescence; Mouth Neoplasms; Neoplasms; Paclitaxel; Phosphorylation; Propidium; Pyrimidines; Pyrroles; Tongue; Tongue Neoplasms; Tyrosine | 2003 |
Inhibition of zebrafish epidermal growth factor receptor activity results in cardiovascular defects.
Topics: Amino Acid Sequence; Animals; Cardiovascular Abnormalities; ErbB Receptors; Humans; Molecular Sequence Data; Pyrimidines; Pyrroles; Quinazolines; Rats; Tyrphostins; Zebrafish | 2003 |
Renal cell carcinoma bone metastasis: epidermal growth factor receptor targeting.
Topics: Animals; Antineoplastic Agents, Phytogenic; Bone Neoplasms; Carcinoma, Renal Cell; ErbB Receptors; Kidney Neoplasms; Mice; Mice, Nude; Paclitaxel; Phosphorylation; Pyrimidines; Pyrroles; Tumor Cells, Cultured | 2003 |
Bioassay using epidermal keratinocytes to determine phosphorylation status of the epidermal growth factor receptor in distant neoplasms.
Topics: Animals; Benzimidazoles; Biological Assay; Cell Line, Tumor; Dose-Response Relationship, Drug; Endocytosis; Epidermal Growth Factor; ErbB Receptors; Fibrosarcoma; Keratinocytes; Mice; Mice, Inbred C3H; Microscopy, Fluorescence; Neoplasm Transplantation; Phosphorylation; Pyrimidines; Pyrroles; Specific Pathogen-Free Organisms | 2004 |
Novel radiosensitizers for locally advanced epithelial tumors: inhibition of the PI3K/Akt survival pathway in tumor cells and in tumor-associated endothelial cells as a novel treatment strategy?
Topics: Cell Survival; Combined Modality Therapy; Down-Regulation; Endothelial Cells; Enzyme Inhibitors; ErbB Receptors; Neoplasm Proteins; Neoplasms, Glandular and Epithelial; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phthalazines; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; Pyrimidines; Pyrroles; Radiation-Sensitizing Agents; Receptors, Vascular Endothelial Growth Factor; Staurosporine | 2004 |
Hypoxia increases resistance of human pancreatic cancer cells to apoptosis induced by gemcitabine.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Apoptosis; Blotting, Western; Butadienes; Cell Division; Cell Line, Tumor; Chromones; Deoxycytidine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Gemcitabine; Humans; Hypoxia; Mitogen-Activated Protein Kinases; Morpholines; Neovascularization, Pathologic; NF-kappa B; Nitriles; Oxygen; Pancreatic Neoplasms; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein-Tyrosine Kinases; Pyrimidines; Pyrroles; Signal Transduction; Sp1 Transcription Factor; Time Factors; Tyrosine | 2004 |
Simultaneous blockade of platelet-derived growth factor-receptor and epidermal growth factor-receptor signaling and systemic administration of paclitaxel as therapy for human prostate cancer metastasis in bone of nude mice.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzamides; Bone Neoplasms; Cell Division; Enzyme Inhibitors; ErbB Receptors; Humans; Imatinib Mesylate; In Situ Nick-End Labeling; Male; Mice; Mice, Nude; Paclitaxel; Phosphorylation; Piperazines; Platelet Endothelial Cell Adhesion Molecule-1; Prostatic Neoplasms; Pyrimidines; Pyrroles; Receptors, Platelet-Derived Growth Factor; Substrate Specificity; Xenograft Model Antitumor Assays | 2004 |
Epidermal growth factor receptor inhibition promotes desmosome assembly and strengthens intercellular adhesion in squamous cell carcinoma cells.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Cadherins; Calcium; Carcinoma, Squamous Cell; Cell Adhesion; Cell Communication; Cell Line, Tumor; Cetuximab; Culture Media, Conditioned; Cytoskeletal Proteins; Desmocollins; Desmoglein 2; Desmogleins; Desmoplakins; Desmosomes; Dose-Response Relationship, Drug; ErbB Receptors; gamma Catenin; Humans; Immunoblotting; Microscopy, Phase-Contrast; Mouth Neoplasms; Phenotype; Phosphorylation; Precipitin Tests; Pyrimidines; Pyrroles; Subcellular Fractions; Tyrosine | 2004 |
Relationship between antiapoptotic molecules and metastatic potency and the involvement of DNA-dependent protein kinase in the chemosensitization of metastatic human cancer cells by epidermal growth factor receptor blockade.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Cell Line, Tumor; DNA-Activated Protein Kinase; DNA-Binding Proteins; Drug Synergism; Electrophoretic Mobility Shift Assay; ErbB Receptors; Etoposide; Genes, MDR; Humans; Indicators and Reagents; Melanoma; Neoplasm Metastasis; Nuclear Proteins; Protein Serine-Threonine Kinases; Pyrimidines; Pyrroles; Radiation-Sensitizing Agents; Rats | 2004 |
Hepatic transport of PKI166, an epidermal growth factor receptor kinase inhibitor of the pyrrolo-pyrimidine class, and its main metabolite, ACU154.
Topics: Animals; Biological Transport; Cell Line; Dogs; Dose-Response Relationship, Drug; Enzyme Inhibitors; ErbB Receptors; Liver; Pyrimidines; Pyrroles; Rats; Rats, Wistar | 2004 |
Epidermal growth factor receptor inhibition attenuates early kidney enlargement in experimental diabetes.
Topics: Animals; Apoptosis; Bromodeoxyuridine; Cell Division; Cell Line; Diabetes Mellitus, Experimental; Epithelial Cells; ErbB Receptors; Glomerular Filtration Rate; Immunohistochemistry; Kidney; Kidney Glomerulus; Male; Organ Size; Proliferating Cell Nuclear Antigen; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley | 2004 |
HER2/neu kinase-dependent modulation of androgen receptor function through effects on DNA binding and stability.
Topics: Animals; Chlorocebus aethiops; COS Cells; DNA, Neoplasm; ErbB Receptors; Humans; Male; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyrimidines; Pyrroles; Receptor, ErbB-2; Receptors, Androgen; RNA, Small Interfering; Signal Transduction; Transfection; Tumor Cells, Cultured | 2004 |
Epidermal growth factor receptor tyrosine kinase inhibitor does not improve paclitaxel effect in an orthotopic mouse model of lung cancer.
Topics: Adenocarcinoma, Bronchiolo-Alveolar; Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Non-Small-Cell Lung; Drug Therapy, Combination; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Fibroblast Growth Factor 2; Humans; Lung Neoplasms; Male; Mice; Mice, Nude; Mitogen-Activated Protein Kinases; Models, Animal; Paclitaxel; Phosphorylation; Pyrimidines; Pyrroles; Survival Rate | 2004 |
Monitoring antiproliferative responses to kinase inhibitor therapy in mice with 3'-deoxy-3'-18F-fluorothymidine PET.
Topics: Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Dideoxynucleosides; Disease Models, Animal; Fluorodeoxyglucose F18; Humans; Mice; Mice, SCID; Neoplasm Invasiveness; Positron-Emission Tomography; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Radiopharmaceuticals; Treatment Outcome | 2005 |
Cytotoxic effect of the Her-2/Her-1 inhibitor PKI-166 on renal cancer cells expressing the connexin 32 gene.
Topics: Carcinoma, Renal Cell; Cell Line, Tumor; Connexins; Dose-Response Relationship, Drug; ErbB Receptors; Gap Junction beta-1 Protein; Genes, erbB-1; Growth Inhibitors; Humans; Kidney Neoplasms; Pyrimidines; Pyrroles; Receptor, ErbB-2 | 2005 |
Microanatomy of axon/glial signaling during Wallerian degeneration.
Topics: Analysis of Variance; Animals; Axotomy; Blotting, Western; Bromodeoxyuridine; Cell Proliferation; Cells, Cultured; Coculture Techniques; Demyelinating Diseases; Disease Models, Animal; Embryo, Mammalian; Female; Fluorescent Antibody Technique; Ganglia, Spinal; Gene Expression; Glycoproteins; Immunoprecipitation; Mitogen-Activated Protein Kinase Kinases; Myelin Basic Protein; Myelin Sheath; Neuregulins; Neuroglia; Neurons; Platelet-Derived Growth Factor; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptor Protein-Tyrosine Kinases; Receptor, ErbB-2; Schwann Cells; Sciatic Neuropathy; Signal Transduction; Sodium Channels; Time Factors; Wallerian Degeneration | 2005 |
Construction of a novel constitutively active chimeric EGFR to identify new targets for therapy.
Topics: Animals; Brain; CD3 Complex; Cell Proliferation; Cells, Cultured; Endothelium, Vascular; ErbB Receptors; Humans; Kidney; Ligands; Mice; Mitogen-Activated Protein Kinases; Phenotype; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyrimidines; Pyrroles; Receptors, Antigen, T-Cell; Recombinant Fusion Proteins; Signal Transduction; STAT3 Transcription Factor | 2005 |
Tyrosine kinases: maiming myelin in leprosy.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Butadienes; Cells, Cultured; Coculture Techniques; Enzyme Activation; Enzyme Inhibitors; Homeodomain Proteins; Humans; Leprosy; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Models, Biological; Mycobacterium leprae; Myelin Sheath; Neurons; Nitriles; Phosphorylation; Pyrimidines; Pyrroles; Receptor, ErbB-2; Schwann Cells; Trastuzumab | 2006 |
ErbB2 receptor tyrosine kinase signaling mediates early demyelination induced by leprosy bacilli.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Butadienes; Cells, Cultured; Chlorocebus aethiops; Coculture Techniques; COS Cells; Demyelinating Diseases; Enzyme Activation; Enzyme Inhibitors; HeLa Cells; Humans; Leprosy; Mice; Mice, Knockout; Mice, Nude; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mycobacterium leprae; Nitriles; Pyrimidines; Pyrroles; Rats; Receptor, ErbB-2; Schwann Cells; Sciatic Nerve; Signal Transduction; Trastuzumab | 2006 |
Regeneration of human epidermis on acellular dermis is impeded by small-molecule inhibitors of EGF receptor tyrosine kinase.
Topics: Cell Proliferation; Cells, Cultured; Dermis; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; Epidermis; ErbB Receptors; Humans; Keratinocytes; Models, Biological; Organ Culture Techniques; Protein-Tyrosine Kinases; Psoriasis; Pyrimidines; Pyrroles; Receptor, ErbB-2; Regeneration | 2008 |
Phosphorylated epidermal growth factor receptor on tumor-associated endothelial cells is a primary target for therapy with tyrosine kinase inhibitors.
Topics: Animals; Apoptosis; Blotting, Western; Camptothecin; Cecum; Cell Proliferation; Colonic Neoplasms; Drug Therapy, Combination; Endothelial Cells; Enzyme Inhibitors; ErbB Receptors; Humans; Immunoenzyme Techniques; In Situ Nick-End Labeling; Irinotecan; Lymphatic Metastasis; Male; Mice; Mice, Nude; Necrosis; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrimidines; Pyrroles; Receptor, ErbB-2; RNA, Small Interfering; Topoisomerase I Inhibitors; Transforming Growth Factor alpha | 2008 |
Heparin binding epidermal growth factor in renal ischaemia/reperfusion injury.
Topics: Adult; Aged; Animals; Cells, Cultured; Disease Models, Animal; Epidermal Growth Factor; Female; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Kidney; Kidney Transplantation; Male; Mice; Middle Aged; Pyrimidines; Pyrroles; Rats; Rats, Wistar; Reperfusion Injury; RNA, Messenger; Up-Regulation; Young Adult | 2010 |
Axonal neuregulin 1 type III activates NF-kappaB in Schwann cells during myelin formation.
Topics: Animals; Axons; Chlorocebus aethiops; Colforsin; COS Cells; Gene Deletion; Mice; Models, Biological; Myelin Sheath; Neuregulin-1; NF-kappa B; Protein Isoforms; Protein Structure, Tertiary; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Schwann Cells; Signal Transduction | 2010 |
Inhibition of the epidermal growth factor receptor preserves podocytes and attenuates albuminuria in experimental diabetic nephropathy.
Topics: Albuminuria; Animals; Biomarkers; Diabetes Mellitus, Experimental; Diabetic Nephropathies; ErbB Receptors; Female; Hypertrophy; Kidney; Mice; Podocytes; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Rats; Rats, Transgenic; Renin; WT1 Proteins | 2011 |
PKI 166 induced redox signalling and apoptosis through activation of p53, MAP kinase and caspase pathway in epidermoid carcinoma.
Topics: Apoptosis; Blotting, Western; Carcinoma, Squamous Cell; Caspases; Catalase; Cell Cycle; Cell Proliferation; Cytochromes c; ErbB Receptors; Humans; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Mitochondria; Mitogen-Activated Protein Kinases; Oxidation-Reduction; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Pyrimidines; Pyrroles; Reactive Oxygen Species; Signal Transduction; Superoxide Dismutase; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2012 |
Epidermal growth factor receptor inhibitor PKI-166 governs cardiovascular protection without beneficial effects on the kidney in hypertensive 5/6 nephrectomized rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta, Thoracic; Blood Pressure; Cardiotonic Agents; ErbB Receptors; Hypertension, Renal; Immunohistochemistry; Kidney; Lisinopril; Male; Mesenteric Arteries; Muscle Contraction; Muscle Tonus; Muscle, Smooth, Vascular; Nephrectomy; Proteinuria; Pyrimidines; Pyrroles; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptors, Adrenergic, alpha-1 | 2013 |
New chemical scaffolds for human african trypanosomiasis lead discovery from a screen of tyrosine kinase inhibitor drugs.
Topics: Animals; Axitinib; Benzamides; Erlotinib Hydrochloride; Female; HeLa Cells; Humans; Imatinib Mesylate; Imidazoles; Indazoles; Indoles; Lapatinib; Mice; Morpholines; Piperazines; Protein Kinase Inhibitors; Purines; Pyrimidines; Pyrroles; Quinazolines; Sunitinib; Trypanosomiasis, African | 2014 |
Podocyte hypertrophy precedes apoptosis under experimental diabetic conditions.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Aspartic Acid; Caspase 3; Caspase Inhibitors; Cells, Cultured; Diabetes Mellitus, Experimental; ErbB Receptors; Gene Expression; Hypertrophy; Kidney Glomerulus; Male; Mice; Podocytes; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Rats, Sprague-Dawley; Streptozocin | 2015 |