pyrroles has been researched along with piperidines in 1187 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 26 (2.19) | 18.7374 |
| 1990's | 32 (2.70) | 18.2507 |
| 2000's | 90 (7.58) | 29.6817 |
| 2010's | 814 (68.58) | 24.3611 |
| 2020's | 225 (18.96) | 2.80 |
| Authors | Studies |
|---|---|
| Möhrle, H; Specks, F | 1 |
| Leidig, A; Nebel, U; Peters, T; Wermelskirchen, D; Wilffert, B; Wirth, A | 1 |
| Shikada, K; Tanaka, S | 3 |
| Winchester, B | 1 |
| Shikada, K; Tanaka, S; Yamamoto, A | 3 |
| Pinder, AR | 1 |
| Nebel, U; Peters, T; Wermelskirchen, D; Wilffert, B; Wirth, A | 1 |
| Arakawa, C; Masuda, Y; Shigenobu, K; Tanaka, S; Yokoyama, T | 1 |
| Kageyama, C; Shigenobu, K; Watanabe, M | 1 |
| Arakawa, C; Kasuya, Y; Masuda, Y; Miyajima, M; Shigenobu, K; Tanaka, S; Yamashita, T | 1 |
| Dzwonczyk, S; Grover, GJ; Sargent, CA; Sleph, PG; Smith, MA | 1 |
| Gristwood, WE | 1 |
| Neurath, G | 1 |
| Gotto, AM; Kon, H | 1 |
| Chopek, M; Gergely, J; Seidel, JC | 1 |
| Berliner, LJ | 1 |
| Berliner, LJ; Wong, SS | 1 |
| Eckert, H; Hopf, A | 1 |
| Gorrod, JW; Jenner, P | 1 |
| Golovnia, RV; Khorlina, IM; Sokolov, VE; Zhuravleva, IL | 1 |
| Corrado, L; Felsenfeld, H; Kubilus, J | 1 |
| Nigam, IC; Radecka, C | 1 |
| Fujikura, N; Kawamura, N; Masuda, Y; Tanaka, S; Yamashita, T | 1 |
| Masuda, Y; Tanaka, S; Yamashita, T | 1 |
| Kato, Y; Matsuda, T; Okazaki, K; Shigenobu, K; Tanaka, H | 1 |
| Almond, HR; Carmosin, RJ; Carson, JR; Pitis, PM; Stables, JP; Swinyard, EA; Vaught, JL; White, HS; Wolf, HH | 1 |
| Kamato, T; Miyata, K; Nagakura, Y; Yamano, M | 1 |
| de La Fuente, JL; Liras, P; Martín, JF; Rumbero, A | 1 |
| Cao, BJ; Rodgers, RJ | 1 |
| Bell, P; Sosnovsky, G | 1 |
| Bobirnac, I; Bruinvels, AT; Danzeisen, M; Gazi, L; Geisse, S; Hoyer, D; Schoeffter, P; Schüpbach, E; Sommer, B; Tricklebank, M | 1 |
| Brown, NA; McAllister, G; Milligan, G; Pillai, G; Seabrook, GR | 1 |
| Chari, S; Deth, RC; DuRand, CJ; Kotb, M; Kramer, ML; Liu, D; Nagata, M; Ouellette, D; Sharma, A; Shim, S; Tan, W; Wick, PF | 1 |
| Buzas, A; Duchêne, P; Houin, G; Ladure, P; Laneury, JP; Merour, JY; Ollivier, R; Tran, G | 1 |
| Bobirnac, I; Danzeisen, M; Gazi, L; Hoyer, D; Langenegger, D; Schoeffter, P; Schüpbach, E; Sommer, B; Tricklebank, M | 1 |
| Boxer, PA; Gregory, TF; Meltzer, LT; Serpa, KA; Wise, LD; Wright, JL | 1 |
| Chaki, S; Kawashima, N; Okuyama, S; Omura, T; Tomisawa, K | 1 |
| Egan, RW; Hey, JA; Kreutner, W; Rizzo, CA; Valentine, AF | 1 |
| Asai, F; Fujimoto, K; Goto, R; Hayakawa, M; Ito, R; Ogawa, T; Sugidachi, A; Tanaka, N | 1 |
| Audinot, V; Cussac, D; Dubuffet, T; Gobert, A; Lavielle, G; Lejeune, F; Millan, MJ; Newman-Tancredi, A; Rivet, JM | 1 |
| Brocco, M; Dekeyne, A; Dubuffet, T; Lavielle, G; Millan, MJ; Rivet, JM | 1 |
| De La Garza, R; Madras, BK | 1 |
| Henry, BL; LaHoste, GJ; Marshall, JF | 1 |
| O'Hagan, D | 1 |
| Andreani, A; Cavalli, A; Granaiola, M; Guardigli, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Recanatini, M; Roda, A | 1 |
| Biernat, J; Mandelkow, E; Mandelkow, EM; Meijer, L; Timm, T; Wu, YZ; Zheng-Fischhöfer, Q | 1 |
| Cervetto, L; Demontis, GC; Longoni, B; Macchia, B; Macchia, M; Minutolo, F; Orlandini, E; Ortore, G; Papi, C; Sbrana, A | 1 |
| Rosen, LS | 1 |
| Ferguson, JW; Hayes, PC; Newby, DE; Therapondos, G | 1 |
| Amano, Y; Imura, Y; Ishikawa, E; Nishimoto, T; Sugiyama, Y; Tozawa, Ri | 1 |
| Cassels, A; Cole, C; Hughes, MA; Lexchin, J; McCormack, JP; Mintzes, B | 1 |
| Desvignes, C; Mons, G; Rodier, D; Rouquier, L; Soubrié, P; Souilhac, J; Steinberg, R | 1 |
| Chapman, KL; Hutson, PH; Marston, D; Patel, S; Ragan, CI | 1 |
| Chaperon, F; Neijt, HC; Tricklebank, MD; Unger, L | 1 |
| Averbeck, B; Reeh, WP; Zimmermann, K | 1 |
| Branchek, TA; Cohen, ML; Erickson, JA; Filla, SA; Johnson, KW; Mathes, BM; Nelson, DL; Phebus, LA; Schaus, JM; Schenck, KW; Wainscott, DB; Zgombick, JM | 1 |
| Cao, C; Cho, KW; Han, JH; Kim, SH; Kim, SZ | 1 |
| MANN, PJ; SMITHIES, WR | 1 |
| CLARKE, AJ; MANN, PJ | 1 |
| HASSE, K; SCHMID, G | 1 |
| ASATOOR, AM; MILNE, MD; SIMENHOFF, ML; ZILVA, JF | 1 |
| HAMANA, M; NODA, H | 1 |
| FINGER, H; FRETZDORFF, AM; SCHNEIDER, F; SEYNSCHE, K; WEITZEL, G | 1 |
| BIEL, JH; HOYA, WK; LEISER, HA; MITCHELL, TF; ROBERTSON, JE | 1 |
| BROWN, GB; CRESSWELL, RM; STRAUSS, T | 1 |
| KASE, Y; MUTO, M; YUIZONO, T | 1 |
| HONEGGER, CG; LANGEMANN, HM | 1 |
| LUCKNER, M | 1 |
| ORTH, RE | 1 |
| MASON, DF; WIEN, R | 1 |
| Calixto, JB; El Sayah, M | 1 |
| Baker, DL; Ball, DJ; Beals, CR; Beckius, GE; Blumenkopf, TA; Borie, DC; Brissette, WH; Brown, MF; Casavant, JM; Changelian, PS; Conklyn, MJ; Des Etages, SG; Doty, JL; Elliott, EA; Finco-Kent, D; Fisher, DA; Fisher, MB; Flanagan, ME; Gaweco, AS; Hayes, LS; Higgins, J; Hines, M; Holm, B; Johnson, KS; Kawabata, TT; Kent, CR; Koslov, ER; Kudlacz, EM; Larson, M; Lillie, BM; Littman, BH; Magna, HA; Magnuson, KS; Martin, WH; McCurdy, SP; Milici, AJ; Morris, RE; Moyer, JD; Munchhof, MJ; Nelms, LF; O'Shea, JJ; Paniagua, R; Perry, BD; Reitz, B; Rizzuti, BJ; Saltarelli, MJ; Sawyer, PS; Shang-Poa, C; Si, MS; Smith, JF; Strelevitz, TJ; Su, C; Subramanyam, C; Sun, J; Whipple, DA; Woodworth, TG; Yoon, K; Zagouras, P; Zhou, YJ | 1 |
| Bradesi, S; Mayer, EA; McRoberts, JA; Miller, JC; Ohning, G; Sablad, M; Schwetz, I; Zhou, H | 1 |
| Shiotsu, Y | 1 |
| Bennani, YL; Cowart, M; Esbenshade, TA; Hancock, AA; Pratt, JK; Stewart, AO | 1 |
| Fresco, P; Gonçalves, J; Pinto, E; Saraiva, L | 1 |
| Borisova, TN; Kulikova, LN; Soklakova, TA; Varlamov, AV; Voskressensky, LG | 1 |
| McGrath, P; Parng, C; Semino, C; Seng, WL | 1 |
| Plunkett, AO | 1 |
| Andresen, C; Changelian, P; Conklyn, M; Kudlacz, E | 1 |
| Borie, DC; Changelian, PS; O'Shea, JJ | 1 |
| Ball, DA; Borie, DC; Brissette, WH; Campbell, A; Changelian, PS; Elliott, EA; Flores, MG; Hawkins, J; Higgins, JP; Holm, B; Kudlacz, EM; Larson, MJ; Lau, M; Morris, RE; Paniagua, R; Reitz, BA; Rousvoal, G; Si, MS; Zhang, S | 1 |
| du Manoir, J; Francia, G; Hicklin, DJ; Kerbel, RS; Ma, L; Rak, J; Viloria-Petit, A | 1 |
| Borie, DC; Campbell, A; Changelian, PS; Paniagua, R; Prakash, C; Reitz, BA | 1 |
| Thompson, JE | 1 |
| Claudel, S; Coutrot, P; Didierjean, C; Grison, C | 1 |
| Aalami, O; Borie, DC; Campbell, A; Changelian, PS; Flores, MG; Paniagua, R; Reitz, BA; Rousvoal, G; Si, MS; Zhang, S | 1 |
| Whiting, PJ | 1 |
| Ball, DJ; Borie, DC; Brissette, WH; Campbell, A; Changelian, PS; Elliott, EA; Flores, MG; Higgins, JP; Kudlacz, EM; Larson, MJ; Reitz, BA; Rousvoal, G; Zhang, S | 1 |
| Nuwayhid, SJ; Werling, LL | 1 |
| Arnold, T; Dost, R; Egerland, U; Grunwald, C; Höfgen, N; Hofmann, HJ; Lankau, HJ; Rundfeldt, C; Unverferth, K | 1 |
| Ardizzoni, A; Franciosi, V; Tiseo, M | 1 |
| Battista, K; Bignan, GC; Connolly, PJ; Liu, J; Middleton, SA; Orsini, MJ; Reitz, AB | 1 |
| Wang, D; Wang, T | 1 |
| Ikezoe, T; Koeffler, HP; Nishioka, C; Taguchi, H; Taguchi, T; Yang, Y; Zhu, WG | 1 |
| Alvarez, R; Botta, M; Corelli, F; Focher, F; Ghiron, C; Lossani, A; Manetti, F; Mugnaini, C; Semeraro, T; Valensin, S | 1 |
| Berry, GJ; Borie, DC; Changelian, PS; Flores, MG; Lau, M; Reitz, BA; Rousvoal, G; Si, MS; Zhang, S | 1 |
| Brown, SE; Choi, S; Fan, J; Fathi, Z; Jenkins, S; Kluender, HC; Konkar, A; Lavoie, R; Mays, R; Natoli, J; O'Connor, SJ; Ortiz, AA; Podlogar, B; Smith, RA; Taing, C; Tomlinson, S; Tritto, T; Zhang, Z | 1 |
| Hampton, T | 1 |
| Herbst, RS | 1 |
| Hiejima, Y; Katsumura, Y; Sakai, S; Takahashi, K; Tezuka, H; Watanabe, M | 1 |
| Ardizzoni, A; Tiseo, M | 1 |
| Chang, M; Chen, P; Fink, BE; Gavai, A; Han, WC; Johnson, W; Langley, D; Leavitt, K; Lee, FY; Marathe, P; Mastalerz, H; Norris, D; Oppenheimer, S; Sleczka, B; Tarrant, J; Tokarski, JS; Vite, GD; Vyas, DM; Wong, H; Wong, TW; Zhang, G; Zhang, H | 1 |
| Cabebe, E; Wakelee, H | 1 |
| Ling, X; Sun, W; Sun, Z; Wang, Y; Xiao, J; Yin, C | 1 |
| Amano, T; Ariga, H; Ishida, T; Kimura, T; Matsueda, K; Tajiri, H; Torii, A; Uehara, H; Yamato, S | 1 |
| Armand, JP; Mir, O; Ropert, S | 1 |
| LOCKETT, MF | 1 |
| Bui, B; Italiano, A | 1 |
| Audoly, L; Changelian, P; Kudlacz, EM; Milici, AJ; Zwillich, S | 1 |
| Andresen, C; Changelian, P; Conklyn, M; Kudlacz, E; Whitney-Pickett, C | 1 |
| Giordano, S; Petrelli, A | 1 |
| Kloc, R; Luchowska, E; Owe-Larsson, B; Urbanska, EM; Wielosz, M | 1 |
| Lee, CB; Socinski, MA | 1 |
| Cortes, JE; Estrov, Z; Gaikwad, A; Kantarjian, HM; Manshouri, T; Nussenzveig, RH; Prchal, J; Quintás-Cardama, A; Verstovsek, S | 1 |
| Buhl, R; Fischer, B | 1 |
| Gettinger, S | 1 |
| Brennan, D; Chan, G; Chow, V; Gaston, R; Krishnaswami, S; Mendez, R; Ni, G; Pescovitz, MD; Pirsch, J; Swan, S; van Gurp, E; Wang, C; Weimar, W | 1 |
| Abrams, MT; Breslin, MJ; Buser, CA; Coleman, PJ; Cox, CD; Davide, JP; Diehl, RE; Fernandez-Metzler, C; Fraley, ME; Garbaccio, RM; Hamilton, K; Hartman, GD; Huber, HE; Kohl, NE; Kuo, LC; Li, C; Lobell, RB; Mahan, E; Prueksaritanont, T; Schaber, MD; Slaughter, DE; South, VJ; Tao, W; Torrent, M; Walsh, ES; Whitman, DB; Yan, Y | 1 |
| Breazna, A; Doody, R; Feldman, H; Hey-Hadavi, J; Jones, RW; Kivipelto, M; Ramos, H; Schindler, RJ; Sparks, L; Waters, DD | 1 |
| Sabbagh, MN | 1 |
| Loiseau, F; Millan, MJ | 1 |
| Lin, TS | 1 |
| Chen, Z; Costanzi, S; Deflorian, F; Ghoreschi, K; Jiang, JK; Leister, W; Liu, EH; Nguyen, DT; O'Shea, JJ; Perreira, M; Pesu, M; Smith, J; Thomas, CJ | 1 |
| Adermark, L; Lovinger, DM; Talani, G | 1 |
| Baan, CC; Chan, G; Klepper, M; Korevaar, SS; Schoordijk-Verschoor, W; van Gurp, EA; Weimar, W | 1 |
| Boy, MG; Chan, G; Changelian, PS; Chow, VF; Clucas, AT; Gaweco, AS; Krueger, JG; Wang, C; Wilkinson, BE; Zwillich, SH | 1 |
| Backman, JT; Kalliokoski, A; Kurkinen, KJ; Neuvonen, PJ; Niemi, M | 1 |
| Kameda, H; Takeuchi, T | 1 |
| Hayashi, T; Sumida, T | 1 |
| Cannon, C; Chan, G; Gruben, D; Krishnaswami, S; Lawendy, N; Swan, S; Wang, R | 1 |
| Horn, L; Sandler, AB | 1 |
| West, K | 1 |
| Fox, LM; Wang, D; Wang, T; Xia, B | 1 |
| Jury, JC; Morgan, IR; Pyne, SG; Swamy, NK; Willis, AC; Yazici, A | 1 |
| Armstrong, BD; Han, S; Shea, JE; Soto, P | 1 |
| Bloom, BJ; Breedveld, FC; Burgos-Vargas, R; Coombs, JH; Fletcher, MP; Gruben, D; Kremer, JM; Krishnaswami, S; Wilkinson, B; Zerbini, CA; Zwillich, SH | 1 |
| Bloom, BJ; Breedveld, FC; Burgos-Vargas, R; Coombs, JH; Fletcher, MP; Gruben, D; Kremer, JM; Wilkinson, B; Zerbini, CA; Zwillich, SH | 1 |
| Dziadziusko, R; Fennell, D; Gridelli, C; Lacombe, D; Pallis, AG; Serfass, L; van Meerbeeck, JP; Welch, J | 1 |
| Brennan, DC; Bromberg, JS; Busque, S; Chan, G; Fisher, RA; Hariharan, S; Klintmalm, G; Lawendy, N; Leventhal, J; Mulgaonkar, S; Peddi, VR; Shah, T; Slakey, D; Steinberg, S; Vincenti, F; Wang, C | 1 |
| Boggon, TJ; Cornejo, MG; Mercher, T | 1 |
| Fan, X; Hess, EJ; Xu, M | 1 |
| Baan, CC; Chan, G; Korevaar, SS; Mol, W; Quaedackers, ME; van Gurp, EA; van Ijcken, WF; Weimar, W | 1 |
| French, J; Friberg, LE; Gupta, P; Karlsson, MO; Krishnaswami, S | 1 |
| Dianov, GL; Fanta, M; Freschauf, GK; Grassot, JM; Hall, DG; Mani, RS; Mereniuk, TR; Virgen, CA; Weinfeld, M | 1 |
| Sherman, SI | 1 |
| Galle, PR; Gockel, I; Heidel, F; Lang, H; Lyros, O; Moehler, M; Mueller, A; Schimanski, CC | 1 |
| Moretti, S; Puxeddu, E; Romagnoli, S; Voce, P | 1 |
| Joo, KM; Jung, YS; Kang, H; Lee, DS; Lee, HY; Lee, J; Oh, K | 1 |
| Aherne, GW; Caldwell, JJ; Cheung, KM; Collins, I; Davies, TG; de Haven Brandon, A; Eccles, SA; Fazal, L; Garrett, MD; Henley, A; Hunter, LJ; McHardy, T; Raynaud, FI; Rowlands, M; Ruddle, R; Seavers, L; Taylor, K; Valenti, M | 1 |
| Christopher, L; Gavai, A; Marathe, P; Rodrigues, D; Sleczka, B; Tang, Y; Wong, T; Zhang, H | 1 |
| Bright, SA; Campiani, G; Deininger, MW; Lawler, M; Williams, DC; Zisterer, DM | 1 |
| Desplat, V; Fabre, SB; Gay, A; Godde, F; Guillon, J; Jarry, C; Macky, G; Massip, S; Moreau, S; Mossalayi, D; Thiolat, D | 1 |
| Chow, V; Cohen, S; Labadie, RR; Wilkinson, B; Zwillich, SH | 1 |
| Kats-Ugurlu, G; Kiemeney, LA; Leenders, WP; Mulders, PF; Old, LJ; Oosterwijk, E; Oosterwijk-Wakka, JC | 1 |
| Opar, A | 1 |
| Allentoff, A; Caceres-Cortes, J; Chando, T; Christopher, LJ; Ekhato, IV; Hong, H; Humphreys, WG; Iyer, RA; Roongta, V; Su, H; Sun, H | 1 |
| Cooper, JE; Wiseman, AC | 1 |
| Benson, TE; Chrencik, JE; Day, JE; Emmons, TL; Fischer, HD; Gormley, JA; Hall, T; Hirsch, JL; Huang, HC; Jacobsen, EJ; Kiefer, JR; Korniski, B; Leone, JW; Leung, IK; Patny, A; Sommers, CD; Tenbrink, RE; Tomasselli, AG; Weinberg, RA; Williams, JM | 1 |
| Bonvalot, S; Cioffi, A; Dômont, J; Le Cesne, A; Tardieu, M | 1 |
| Arai, Y; Kikuchi, T; Mitazaki, S; Nakagawasai, O; Nakaya, K; Niijima, F; Onogi, H; Sato, A; Tadano, T; Tan-No, K | 1 |
| Barth, F; Boulu, L; Congy, C; Fabre, G; Finance, O; Hortala, L; Rinaldi-Carmona, M; Sadoun, F | 1 |
| Baan, CC; Chan, G; Korevaar, SS; Kraaijeveld, R; Quaedackers, ME; Sewgobind, VD; van der Laan, LJ; Weimar, W | 1 |
| Bourhis, J; De la motte Rouge, T; Deutsch, E; Dorvault, N; Loriot, Y; Mordant, P; Soria, JC | 1 |
| Allentoff, A; Christopher, LJ; Clemens, PL; Harbison, CT; Heller, K; Hong, H; Humphreys, WG; Iyer, RA; Roongta, V; Su, H; Sun, H; Vakkalagadda, BJ; Wong, T; Zhang, S | 1 |
| Belcastro, V; Bosotti, R; Brunetti-Pierri, N; di Bernardo, D; Ferriero, R; Iorio, F; Isacchi, A; Mithbaokar, P; Murino, L; Scacheri, E; Tagliaferri, R | 1 |
| Byoun, OJ; Garmaa, N; Lee, DS; Lee, HY; Oh, K; Park, HB; Seo, MW | 1 |
| Djamali, A; Gordon, RD; Legendre, C; Pietrangeli, CE | 1 |
| Kremer, J; Krishnaswami, S; Riese, RJ | 1 |
| Bareford, MD; Dent, P; Eulitt, P; Hossein, H; Martin, AP; Mitchell, C; Nephew, KP; Yacoub, A; Yang, C | 1 |
| Busque, S; Chan, G; Krishnaswami, S; Lamba, M; Melcher, M; Tafti, B | 1 |
| Ardini, E; Galvani, A; Magnaghi, P; Menichincheri, M; Orsini, P | 1 |
| Hasegawa, E; Konoeda, F; Morita, R; Muto, G; Shichita, T; Sugiyama, Y; Suzuki, N; Yoshida, H; Yoshimura, A | 1 |
| Bonacorsi, S; Caceres-Cortes, J; Christopher, LJ; Hong, H; Hong, Y; Huang, X; Humphreys, WG; Iyer, RA; Roongta, V; Su, H; Tian, Y | 1 |
| Blumenkopf, TA; Brissette, WH; Brown, MF; Casavant, JM; Changelian, PS; Doty, JL; Elliott, EA; Fisher, MB; Flanagan, ME; Hines, M; Kent, C; Kudlacz, EM; Lillie, BM; Magnuson, KS; McCurdy, SP; Munchhof, MJ; Perry, BD; Sawyer, PS; Shang-Poa, C; Strelevitz, TJ; Subramanyam, C; Sun, J; Whipple, DA | 1 |
| Bryant, BR; Chen, J; Jacobson, S; Janik, JE; Jiang, JK; Ju, W; Morris, JC; Oh, U; Sato, N; Tagaya, Y; Thomas, CJ; Waldmann, TA; Zhang, M | 1 |
| Gulati, P; Venkataramanan, R; Vijayakrishnan, L | 1 |
| Chan, G; Krishnaswami, S; Kudlacz, E; Wang, R | 1 |
| Falchetto, R; Hermes, E; Nuninger, F; Tavares, GA; Thoma, G; Vangrevelinghe, E; Zerwes, HG | 1 |
| Fox, LM; Wang, D; Xia, B | 1 |
| Cox, CD; Garbaccio, RM | 1 |
| Batey, MA; de Brito, LR; Hall, AG; Irving, JA; Jackson, G; Leung, HY; Maitland, H; Newell, DR; Squires, MS; Zhao, Y | 1 |
| Iwai, N; Kitazume, T; Nakayama, K | 1 |
| Claes, A; Hamans, BC; Heerschap, A; Jeuken, JW; Leenders, WP; Navis, AC; Wesseling, P | 1 |
| Alsup, JW; Dowty, ME; Gadina, M; Ghoreschi, K; Ghosh, S; Head, RD; Jesson, MI; Kishore, N; LaBranche, TP; Lee, JL; Li, X; Meyer, DM; Minnerly, JC; O'Shea, JJ; Radi, ZA; Steward-Tharp, SM; Storer, CE; Tanaka, M; Thomas, CJ; Warner, JD | 1 |
| Agrawal, N; Chen, C; DiPaola, R; Holen, K; Hsu, K; Liu, G; Rosenberg, E; Stein, M; Tan, AR; Wilding, G; Xue, L | 1 |
| Alves, MM; de Groot, JW; Hofstra, RM; Links, TP; Osinga, J; Plukker, JT; Verbeek, HH | 1 |
| French, JL; Hutmacher, MM; Krishnaswami, S; Menon, S | 1 |
| Bi, SF; Ge, HM; Li, F; Song, YC; Tan, RX | 1 |
| Emanuel, S; Fairchild, C; Fargnoli, J; Fink, B; Gavai, A; Hammell, A; Henley, B; Hilt, C; Hunt, JT; Krishnan, B; Kukral, D; Lee, FY; Lewin, A; Malone, H; Norris, D; Oppenheimer, S; Vite, G; Wong, TW; Yu, C | 1 |
| Arango, BA; Cohen, EE; Perez, CA; Raez, LE; Santos, ES | 1 |
| Ishibashi, H; Izumi, Y; Jiuchi, Y; Komori, A; Maeda, Y; Migita, K; Miyashita, T; Motokawa, S; Nakamura, M; Torigoshi, T | 1 |
| Nakamura, H; Suzuki, M; Tanaka, Y; Toyoizumi, S; Zwillich, SH | 1 |
| Fassnacht, M; Kreissl, MC; Schott, M; Spitzweg, C; Willhauck, MJ | 1 |
| Garber, K | 2 |
| Blay, JY; Chaigneau, L; Curtit, E; Dobi, E; Kalbacher, E; Mansi, L; Nguyen, T; Pivot, X; Viel, E | 1 |
| Christopher, LJ; Hong, H; Humphreys, WG; Iyer, RA; Ma, L; Su, H; Yao, M | 1 |
| French, J; Gruben, D; Tan, H; Thomas, N | 1 |
| Astarita, G; DiPatrizio, NV; Li, X; Piomelli, D; Schwartz, G | 1 |
| Chastain, EM; Getts, DR; Getts, MT; Martin, A; Miller, SD; Shankar, S; Wood, K | 1 |
| Ishibashi, H; Izumi, Y; Jiuchi, Y; Kawakami, A; Koga, T; Komori, A; Maeda, Y; Migita, K; Miyashita, T; Motokawa, S; Nakamura, M; Sato, J; Torigoshi, T; Yamasaki, S | 1 |
| Aiba, Y; Ishibashi, H; Izumi, Y; Jiuchi, Y; Kawakami, A; Koga, T; Komori, A; Maeda, Y; Migita, K; Miyashita, T; Nakamura, M; Yamasaki, S | 1 |
| Asakawa, M; Chiba, K; Kawasumi, M; Kobayashi, T; Miyamoto, T; Mori, T; Morioka, H; Toyama, Y; Yoshida, H; Yoshimura, A | 1 |
| Connell, CA; Cutolo, M; Fleischmann, R; Genovese, MC; Gruben, D; Kanik, KS; Krishnaswami, S; Lee, EB; Sadis, S; Wallenstein, G; Wilkinson, BE; Zwillich, SH | 1 |
| Vincenti, F; Wojciechowski, D | 2 |
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| Gruben, D; Kremer, JM; Krishnaswami, S; Strand, V; Wallenstein, GV; Zwillich, SH | 1 |
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| Adams, AM; Brin, MF; Burstein, R; Melo-Carrillo, A; Schain, AJ; Strassman, AM | 1 |
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| Gómez Castro, S; González Fernández, CM; Gratacós Masmitjà, J; Rebollo Laserna, FJ | 1 |
| Desai, S; LaChance, A; Lo, K; Nambudiri, VE; Villa-Ruiz, C; Vleugels, RA | 1 |
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| Boinpally, R; Butler, M; Jakate, A; Periclou, A | 1 |
| Armuzzi, A; Danese, S; Irving, PM; Lawendy, N; Liguori, G; Mundayat, R; Sandborn, WJ; Sharara, AI; Woolcott, JC | 1 |
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| Benton, S; Farah, R; Freese, R; Hordinsky, M | 1 |
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| Dai, Q; Meng, J; Tao, X; Wang, W; Wang, Z; Yan, Z; Zhou, Q | 1 |
| Askling, J; Barbulescu, A; Chatzidionysiou, K; Forsblad-d'Elia, H; Frisell, T; Kastbom, A; Lindström, U; Turesson, C | 1 |
| Bacci, ED; Bushmakin, AG; Cappelleri, JC; Coates, LC; Fallon, L; Gladman, DD; Helliwell, PS; Wu, J | 1 |
| Balasundaram, MK; Singh, A | 1 |
| Bessette, L; Kinch, CD; Kwok, K; Lukic, T; Mysler, E; On, PV; van Vollenhoven, RF | 1 |
| Abreu, MT; Chaparro, M; Lawendy, N; Lazariciu, I; Mundayat, R; Panaccione, R; Salese, L; Sands, BE; Woolcott, JC | 1 |
| Abello, M; Amador, L; Castillo, D; Gutierrez-Ardila, MV; Guzman, R; Izquierdo, J; Lukic, T; Madariaga, H; Otero, W; Ponce de Leon, D; Reyes, J; Velez, P | 1 |
| Albayda, J; Castillo, R | 1 |
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| Adams, A; Brin, MF; Burstein, R; Houle, TT; Melo-Carrillo, A; Strassman, AM | 1 |
| Buesch, K; de Zárate, IBO; Ferizovic, N; Jiang, J; Landfeldt, E; Summers, J; Werner, C | 1 |
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| Cook, JA; D'Haens, GR; Modesto, I; Mukherjee, A; Nicholas, T; Sandborn, WJ; Su, C; Tsuchiwata, S | 1 |
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| Bilgin, E; Duran, E; Ertenli, İ; Kalyoncu, U; Kiraz, S; Ünaldı, E | 1 |
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| Arbrile, M; Baldovino, S; Barinotti, A; Buccarano, N; Cecchi, I; Crosasso, P; Di Gregorio, F; Di Nunzio, P; Favuzzi, MD; Menegatti, E; Milone, V; Osella, S; Radin, M; Roccatello, D; Rossi, D; Sciascia, S | 1 |
| Álvaro-Gracia, JM; Curtis, JR; Dikranian, AH; Gonzalez-Gay, MA; Paulissen, J; Shi, H; Stockert, L; Takiya, L; Tatulych, S; Wellborne, F | 1 |
| Arias-Santiago, S; Cantudo-Cuenca, MR; Diaz-Calvillo, P; Molina-Leyva, A; Rodriguez-Pozo, JA; Sanchez-Diaz, M; Tercedor-Sánchez, J | 1 |
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| Blumenfeld, AM; Dabruzzo, B; Dodick, DW; Finnegan, M; Li, Y; Lipton, RB; Lu, K; McAllister, P; Miceli, R; Pozo-Rosich, P; Severt, L; Trugman, JM | 1 |
| Arai, S; Hibi, T; Hisamatsu, T; Hoshi, M; Kim, HJ; Matsuoka, K; Shi, N; Tabira, J; Toyoizumi, S; Woo, JS; Ye, BD; Yuasa, H | 1 |
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| Cheng, X; Dai, SM; Du, F; Hu, Q; Jiang, L; Liu, H; Lu, LJ; Ma, L; Shi, H; Su, Y; Tao, YL; Teng, J; Wang, M; Xue, Y; Yang, C; Ye, J; Zhao, D | 1 |
| Ashina, M; Dabruzzo, B; Gandhi, P; Halker Singh, RB; Lipton, RB; Ma, J; McVige, J; Mechtler, L; Stokes, J; Yu, SY | 1 |
282 review(s) available for pyrroles and piperidines
| Article | Year |
|---|---|
Natural and synthetic inhibitors of glycosidases.
Topics: Animals; Carbohydrate Sequence; Glycoproteins; Glycoside Hydrolases; Humans; Indoles; Lysosomal Storage Diseases; Molecular Sequence Data; Molecular Structure; Oligosaccharides; Piperidines; Protein Processing, Post-Translational; Pyrroles; Pyrrolidines | 1992 |
Pyrrole, pyrrolidine, piperidine, pyridine, and azepine alkaloids.
Topics: Alkaloids; Animals; Azepines; Piperidines; Plants; Porifera; Pyridines; Pyrroles; Pyrrolidines | 1992 |
[Nitrogen compounds of tobacco smoke].
Topics: Acridines; Alkaloids; Alkanes; Amines; Amino Acids; Aniline Compounds; Carbazoles; Cyanates; Indoles; Isoquinolines; Ketones; Niacinamide; Nicotiana; Nicotine; Nicotinic Acids; Nitriles; Nitrites; Nitrosamines; Piperidines; Plants, Toxic; Pyrazines; Pyridines; Pyrroles; Pyrrolidines; Quinolines; Quinoxalines; Smoking | 1969 |
Pyrrole, pyrrolidine, pyridine, piperidine and tropane alkaloids.
Topics: Alkaloids; Piperidines; Pyridines; Pyrroles; Pyrrolidines; Tropanes | 2000 |
Inhibitors of the vascular endothelial growth factor receptor.
Topics: Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Bevacizumab; Clinical Trials as Topic; Colorectal Neoplasms; Drug Design; Drug Screening Assays, Antitumor; Endothelial Growth Factors; Enzyme Inhibitors; Humans; Indoles; Intercellular Signaling Peptides and Proteins; Lymphokines; Neoplasm Proteins; Neoplasms; Neovascularization, Pathologic; Phthalazines; Piperidines; Pyridines; Pyrroles; Quinazolines; Recombinant Proteins; RNA, Catalytic; Treatment Failure; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2; Vascular Endothelial Growth Factors | 2002 |
Therapeutic role of vasopressin receptor antagonism in patients with liver cirrhosis.
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Azepines; Benzamides; Benzazepines; Controlled Clinical Trials as Topic; Diuretics; Heart Failure; Homeostasis; Humans; Inappropriate ADH Syndrome; Liver Cirrhosis; Models, Animal; Morpholines; Piperidines; Pyrroles; Quinolones; Rats; Spiro Compounds; Vasopressins | 2003 |
[Current screening for molecular target therapy of cancer].
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Benzamides; Boronic Acids; Bortezomib; Drug Delivery Systems; Drug Screening Assays, Antitumor; Gefitinib; Heat-Shock Proteins; Humans; Imatinib Mesylate; Indoles; Lactones; Mice; Neoplasms; Phthalazines; Piperazines; Piperidines; Pyrazines; Pyridines; Pyrimidines; Pyrroles; Quinazolines; Sunitinib | 2003 |
Pyrrole, pyrrolidine, pyridine, piperidine, and azepine alkaloids.
Topics: Alkaloids; Animals; Azepines; Molecular Structure; Piperidines; Plants; Porifera; Pyridines; Pyrroles; Pyrrolidines | 1994 |
JAK3 inhibition, a viable new modality of immunosuppression for solid organ transplants.
Topics: Animals; Drug Design; Graft Rejection; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Janus Kinase 3; Lymphocytes; Organ Transplantation; Piperidines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrimidines; Pyrroles; Severe Combined Immunodeficiency; Transplantation Immunology; Transplantation, Homologous | 2004 |
JAK protein kinase inhibitors.
Topics: Animals; Drug Design; Enzyme Inhibitors; Forecasting; Gene Expression Regulation; Humans; Janus Kinase 1; Janus Kinase 2; Janus Kinase 3; Mannich Bases; Piperidines; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Pyrimidines; Pyrroles; Quinazolines; Signal Transduction; TYK2 Kinase | 2005 |
GABA-A receptors: a viable target for novel anxiolytics?
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Brain; Drug Design; Drug Evaluation, Preclinical; GABA Agonists; GABA-A Receptor Agonists; Humans; Imidazoles; Indoles; Piperidines; Pyrroles; Receptors, GABA-A | 2006 |
Multi-target inhibitors in non-small cell lung cancer (NSCLC).
Topics: Angiogenesis Inhibitors; Antineoplastic Combined Chemotherapy Protocols; Benzenesulfonates; Carcinoma, Non-Small-Cell Lung; ErbB Receptors; Humans; Indoles; Lung Neoplasms; Medical Oncology; Niacinamide; Phenylurea Compounds; Piperidines; Protein Kinase Inhibitors; Pyridines; Pyrroles; Quinazolines; Sorafenib; Sunitinib | 2006 |
Toxicities of antiangiogenic therapy in non-small-cell lung cancer.
Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Benzenesulfonates; Bevacizumab; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Humans; Indoles; Lung Neoplasms; Niacinamide; Phenylurea Compounds; Piperidines; Pyridines; Pyrroles; Quinazolines; Sorafenib; Sunitinib; Vascular Endothelial Growth Factors | 2006 |
Combination of target agents: challenges and opportunities.
Topics: Antineoplastic Combined Chemotherapy Protocols; Benzenesulfonates; Drug Resistance, Neoplasm; Humans; Indoles; Lung Neoplasms; Niacinamide; Phenylurea Compounds; Piperidines; Pyridines; Pyrroles; Quinazolines; Receptor Protein-Tyrosine Kinases; Sorafenib; Sunitinib | 2007 |
Role of anti-angiogenesis agents in treating NSCLC: focus on bevacizumab and VEGFR tyrosine kinase inhibitors.
Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Benzenesulfonates; Bevacizumab; Carcinoma, Non-Small-Cell Lung; Clinical Trials as Topic; Enzyme Inhibitors; Humans; Indoles; Lung Neoplasms; Neovascularization, Pathologic; Niacinamide; Phenylurea Compounds; Piperidines; Pyridines; Pyrroles; Quinazolines; Signal Transduction; Sorafenib; Sunitinib; Treatment Outcome; Vascular Endothelial Growth Factor Receptor-1 | 2007 |
[Oral drugs inhibiting the VEGF pathway].
Topics: Administration, Oral; Angiogenesis Inhibitors; Animals; Asthenia; Axitinib; Benzenesulfonates; Humans; Hypertension; Imidazoles; Indazoles; Indoles; Neoplasms; Neovascularization, Pathologic; Niacinamide; Phenylurea Compounds; Phthalazines; Piperidines; Proteinuria; Pyridines; Pyrroles; Quinazolines; Receptors, Vascular Endothelial Growth Factor; Sorafenib; Sunitinib; Vascular Endothelial Growth Factor A | 2007 |
[Gastrointestinal stromal tumors: molecular aspects and therapeutic implications].
Topics: Antineoplastic Agents; Benzamides; Benzenesulfonates; Disease Progression; Drug Resistance, Neoplasm; Gastrointestinal Stromal Tumors; Humans; Imatinib Mesylate; Indoles; Mutation; Neoplasm Proteins; Niacinamide; Oligonucleotides; Phenylurea Compounds; Phthalazines; Piperazines; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Pyridines; Pyrimidines; Pyrroles; Receptor, Platelet-Derived Growth Factor alpha; Sorafenib; Staurosporine; Sunitinib; Thiazoles | 2008 |
From single- to multi-target drugs in cancer therapy: when aspecificity becomes an advantage.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Benzenesulfonates; Bevacizumab; Cetuximab; Clinical Trials as Topic; Enzyme Inhibitors; Erlotinib Hydrochloride; Gefitinib; Humans; Imatinib Mesylate; Indoles; Lapatinib; Neoplasms; Neovascularization, Pathologic; Niacinamide; Phenylurea Compounds; Piperazines; Piperidines; Protein-Tyrosine Kinases; Pyridines; Pyrimidines; Pyrroles; Quinazolines; Receptor Protein-Tyrosine Kinases; Sorafenib; Sunitinib; Trastuzumab | 2008 |
Vascular endothelial growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer: a review of recent clinical trials.
Topics: Angiogenesis Inhibitors; Antineoplastic Agents; Benzenesulfonates; Carcinoma, Non-Small-Cell Lung; Clinical Trials as Topic; Humans; Indoles; Neovascularization, Pathologic; Niacinamide; Oligonucleotides; Phenylurea Compounds; Phthalazines; Piperidines; Protein-Tyrosine Kinases; Pyridines; Pyrroles; Quinazolines; Receptors, Vascular Endothelial Growth Factor; Sorafenib; Sunitinib; Treatment Outcome | 2007 |
[Lung cancer].
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Benzenesulfonates; Bevacizumab; Carcinoma, Non-Small-Cell Lung; Chemotherapy, Adjuvant; Combined Modality Therapy; Drugs, Investigational; Erlotinib Hydrochloride; Humans; Indoles; Lung Neoplasms; Mass Screening; Neoplasm Staging; Niacinamide; Phenylurea Compounds; Piperidines; Pneumonectomy; Pyridines; Pyrroles; Quinazolines; Radiotherapy, Adjuvant; Randomized Controlled Trials as Topic; Sorafenib; Sunitinib | 2008 |
Targeted therapy in advanced non-small-cell lung cancer.
Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Benzenesulfonates; Bevacizumab; Carcinoma, Non-Small-Cell Lung; Drug Delivery Systems; Epidermal Growth Factor; Erlotinib Hydrochloride; Humans; Indoles; Lung Neoplasms; Niacinamide; Phenylurea Compounds; Piperidines; Protein Kinase Inhibitors; Pyridines; Pyrroles; Quinazolines; Signal Transduction; Sorafenib; Sunitinib; Treatment Outcome; Vascular Endothelial Growth Factor A | 2008 |
Novel agents in chronic lymphocytic leukemia: efficacy and tolerability of new therapies.
Topics: Antineoplastic Agents; Bendamustine Hydrochloride; Flavonoids; Humans; Indoles; Lenalidomide; Leukemia, Lymphocytic, Chronic, B-Cell; Maximum Tolerated Dose; Nitrogen Mustard Compounds; Piperidines; Pyrroles; Thalidomide; Thionucleotides; Treatment Outcome | 2008 |
[Rheumatoid arthritis].
Topics: Abatacept; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Arthritis, Rheumatoid; Autoantibodies; Cytokines; Humans; Immunoconjugates; Janus Kinase 3; Peptides, Cyclic; Piperidines; Pyrimidines; Pyrroles; T-Lymphocyte Subsets; T-Lymphocytes, Regulatory | 2009 |
[Targeted therapies including monoclonal antibodies for connective tissue diseases].
Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Arthritis, Rheumatoid; B-Lymphocytes; Connective Tissue Diseases; Etanercept; Humans; Immunoglobulin G; Infliximab; Janus Kinase 3; Piperidines; Pyrimidines; Pyrroles; Receptors, Interleukin-6; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha | 2009 |
Emerging data with antiangiogenic therapies in early and advanced non-small-cell lung cancer.
Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Benzenesulfonates; Bevacizumab; Carcinoma, Non-Small-Cell Lung; Clinical Trials as Topic; Humans; Indoles; Lung Neoplasms; Niacinamide; Phenylurea Compounds; Piperidines; Protein Kinase Inhibitors; Pyridines; Pyrroles; Quinazolines; Receptors, Vascular Endothelial Growth Factor; Sorafenib; Sunitinib; Thalidomide; Vascular Endothelial Growth Factor A | 2009 |
CP-690550, a JAK3 inhibitor as an immunosuppressant for the treatment of rheumatoid arthritis, transplant rejection, psoriasis and other immune-mediated disorders.
Topics: Animals; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Evaluation, Preclinical; Graft Rejection; Humans; Immunosuppressive Agents; Janus Kinase 3; Piperidines; Protein Kinase Inhibitors; Psoriasis; Pyrimidines; Pyrroles | 2009 |
Targeted therapies in the treatment of advanced/metastatic NSCLC.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Benzenesulfonates; Bevacizumab; Carcinoma, Non-Small-Cell Lung; Cetuximab; Erlotinib Hydrochloride; Gefitinib; Humans; Indoles; Lung Neoplasms; Niacinamide; Phenylurea Compounds; Piperidines; Pyridines; Pyrroles; Quinazolines; Sorafenib; Sunitinib; Treatment Outcome | 2009 |
JAK3: a two-faced player in hematological disorders.
Topics: Animals; Gene Expression Regulation, Neoplastic; Hematologic Neoplasms; Humans; Interleukin Receptor Common gamma Subunit; Janus Kinase 3; Lymphocytes; Mice; Piperidines; Pyrimidines; Pyrroles; Receptors, Cytokine; Signal Transduction | 2009 |
Tyrosine kinase inhibitors and the thyroid.
Topics: Axitinib; Benzenesulfonates; Clinical Trials as Topic; Gefitinib; Humans; Imidazoles; Indazoles; Indoles; Niacinamide; Oligonucleotides; Pharmaceutical Preparations; Phenylurea Compounds; Piperidines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins B-raf; Pyridines; Pyrimidines; Pyrroles; Quinazolines; Receptors, Vascular Endothelial Growth Factor; Sorafenib; Sulfonamides; Sunitinib; Thyroid Gland; Thyroid Neoplasms | 2009 |
Targeted molecular therapies in thyroid carcinoma.
Topics: Antineoplastic Agents; Axitinib; Benzenesulfonates; Carcinoma, Medullary; Carcinoma, Papillary; Humans; Imidazoles; Indazoles; Indoles; Niacinamide; Oligonucleotides; Phenylurea Compounds; Piperidines; Protein Kinase Inhibitors; Pyridines; Pyrroles; Quinazolines; Sorafenib; Sunitinib; Thyroid Neoplasms | 2009 |
Novel immunosuppressive agents in kidney transplantation.
Topics: Abatacept; Alefacept; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Cyclosporine; Everolimus; Graft Rejection; Graft Survival; Humans; Immunoconjugates; Immunosuppressive Agents; Kidney Transplantation; Piperidines; Pyrimidines; Pyrroles; Quinazolines; Recombinant Fusion Proteins; Sirolimus | 2010 |
[Focus on GIST management].
Topics: Antineoplastic Agents; Benzamides; Benzenesulfonates; Chemotherapy, Adjuvant; Drug Resistance, Neoplasm; Gastrointestinal Stromal Tumors; Humans; Imatinib Mesylate; Indoles; Niacinamide; Phenylurea Compounds; Piperazines; Piperidines; Protein Kinase Inhibitors; Pyridines; Pyrimidines; Pyrroles; Sorafenib; Sunitinib; Thiazoles | 2010 |
Potential of emerging immunosuppressive strategies to improve the posttransplant cardiovascular risk profile.
Topics: Abatacept; Cardiovascular Diseases; Clinical Trials as Topic; Graft Rejection; Humans; Immunoconjugates; Immunosuppression Therapy; Immunosuppressive Agents; Janus Kinase 3; Kidney Transplantation; Piperidines; Pyrimidines; Pyrroles | 2010 |
Inhibition of JAK kinases in patients with rheumatoid arthritis: scientific rationale and clinical outcomes.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Disease Models, Animal; Drug Therapy, Combination; Enzyme Inhibitors; Health Status; Humans; Janus Kinase 3; Methotrexate; Piperidines; Pyrimidines; Pyrroles; Severity of Illness Index; Treatment Outcome | 2010 |
Anaplastic Lymphoma Kinase: role in specific tumours, and development of small molecule inhibitors for cancer therapy.
Topics: Anaplastic Lymphoma Kinase; Animals; Crizotinib; Genetic Predisposition to Disease; Humans; Molecular Structure; Mutation; Neoplasms; Piperidines; Protein-Tyrosine Kinases; Pyrazoles; Pyridines; Pyrimidines; Pyrroles; Receptor Protein-Tyrosine Kinases | 2010 |
Treating inflammation with the Janus kinase inhibitor CP-690,550.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Autoimmune Diseases; Graft Rejection; Humans; Immunosuppressive Agents; Inflammation; Isoenzymes; Janus Kinase 3; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Signal Transduction; STAT Transcription Factors | 2011 |
Tofacitinib.
Topics: Animals; Clinical Trials as Topic; Drugs, Investigational; Humans; Immunosuppressive Agents; Janus Kinase 3; Piperidines; Pyrimidines; Pyrroles | 2010 |
Discovery of allosteric inhibitors of kinesin spindle protein (KSP) for the treatment of taxane-refractory cancer: MK-0731 and analogs.
Topics: Allosteric Regulation; Antineoplastic Agents; Drug Discovery; Humans; Kinesins; Neoplasms; Piperidines; Pyrroles; Taxoids | 2010 |
Novel molecular targeted therapies for refractory thyroid cancer.
Topics: Angiogenesis Inhibitors; Anilides; Antineoplastic Agents; Axitinib; Benzamides; Benzenesulfonates; Benzoquinones; Bibenzyls; Boronic Acids; Bortezomib; Depsipeptides; ErbB Receptors; Gefitinib; Histone Deacetylase Inhibitors; HSP90 Heat-Shock Proteins; Humans; Hydroxamic Acids; Imatinib Mesylate; Imidazoles; Indazoles; Indoles; Lactams, Macrocyclic; Lenalidomide; Niacinamide; Oligonucleotides; Phenylurea Compounds; Piperazines; Piperidines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-kit; Pyrazines; Pyridines; Pyrimidines; Pyrroles; Quinazolines; Quinolines; Receptor Protein-Tyrosine Kinases; Receptors, Vascular Endothelial Growth Factor; Sorafenib; Sulfonamides; Sunitinib; Thalidomide; Thyroid Neoplasms; Valproic Acid; Vorinostat | 2012 |
Current landscape for T-cell targeting in autoimmunity and transplantation.
Topics: Autoimmune Diseases; Calcineurin Inhibitors; Cell Differentiation; Cell Proliferation; Cytokines; Hematopoietic Stem Cell Transplantation; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Janus Kinase 3; Organ Transplantation; Piperidines; Protein Kinase C; Pyrimidines; Pyrroles; Quinazolines; Receptors, Cytokine; T-Lymphocytes; Transplantation Immunology; Transplantation Tolerance | 2011 |
Targeting JAK3 in kidney transplantation: current status and future options.
Topics: Graft Rejection; Graft Survival; Humans; Immunosuppressive Agents; Janus Kinase 3; Kidney Transplantation; Molecular Targeted Therapy; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Time Factors; Treatment Outcome | 2011 |
[Dermatologic side effects induced by new angiogenesis inhibitors].
Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Benzenesulfonates; Bevacizumab; Drug Eruptions; Humans; Indazoles; Indoles; Molecular Targeted Therapy; Niacinamide; Phenylurea Compounds; Piperidines; Pyridines; Pyrimidines; Pyrroles; Quinazolines; Skin; Sorafenib; Sulfonamides; Sunitinib | 2011 |
Promising new treatments for rheumatoid arthritis - the kinase inhibitors.
Topics: Aminopyridines; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Intracellular Signaling Peptides and Proteins; Janus Kinases; Morpholines; Oxazines; Piperidines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyridines; Pyrimidines; Pyrroles; Syk Kinase; Treatment Outcome | 2011 |
Systemic therapy for advanced gastrointestinal stromal tumors: beyond imatinib.
Topics: Antineoplastic Agents; Benzamides; Gastrointestinal Neoplasms; Gastrointestinal Stromal Tumors; Humans; Imatinib Mesylate; Indoles; Mutation; Piperazines; Piperidines; Proto-Oncogene Proteins c-kit; Pyridines; Pyrimidines; Pyrroles; Receptors, Platelet-Derived Growth Factor; Sunitinib; Thiazoles | 2011 |
[Recent progress in the treatment of rheumatoid arthritis].
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Denosumab; Etanercept; Humans; Immunoglobulin G; Infliximab; Interleukin-6; Methotrexate; Molecular Targeted Therapy; Piperidines; Pyrimidines; Pyrroles; RANK Ligand; Receptors, Tumor Necrosis Factor; Reference Standards; Remission Induction; Tumor Necrosis Factor-alpha | 2012 |
Novel small-molecular therapeutics for rheumatoid arthritis.
Topics: Aminopyridines; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Janus Kinases; Molecular Targeted Therapy; Morpholines; Oxazines; Piperidines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyridines; Pyrimidines; Pyrroles | 2012 |
[Possibilities for inhibiting tumor-induced angiogenesis: results with multi-target tyrosine kinase inhibitors].
Topics: Angiogenesis Inhibitors; Animals; Axitinib; Benzenesulfonates; Humans; Imidazoles; Indazoles; Indoles; Neoplasms; Neovascularization, Pathologic; Niacinamide; Oligonucleotides; Phenylurea Compounds; Phthalazines; Piperidines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyridines; Pyrimidines; Pyrroles; Quinazolines; Receptor Protein-Tyrosine Kinases; Receptors, Fibroblast Growth Factor; Receptors, Platelet-Derived Growth Factor; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Sorafenib; Sulfonamides; Sunitinib | 2012 |
Tofacitinib for the treatment of rheumatoid arthritis.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Humans; Janus Kinase 3; Piperidines; Pyrimidines; Pyrroles; Treatment Outcome | 2012 |
Are calcineurin inhibitors-free regimens ready for prime time?
Topics: Abatacept; Calcineurin Inhibitors; Drug Therapy, Combination; Graft Rejection; Graft Survival; Humans; Immunoconjugates; Immunosuppressive Agents; Kidney Diseases; Piperidines; Pyrimidines; Pyrroles; Time Factors; Treatment Outcome | 2012 |
JAK inhibitors in psoriasis: a promising new treatment modality.
Topics: Animals; Cytokines; Humans; Janus Kinases; Nitriles; Piperidines; Psoriasis; Pyrazoles; Pyrimidines; Pyrroles; Severity of Illness Index | 2012 |
Receptor tyrosine kinase inhibitors: molecularly targeted drugs for veterinary cancer therapy.
Topics: Animals; Antineoplastic Agents; Benzamides; Drug Therapy, Combination; Humans; Indoles; Neoplasms; Piperidines; Pyridines; Pyrroles; Receptor Protein-Tyrosine Kinases; Thiazoles | 2012 |
Inhibition of RET activated pathways: novel strategies for therapeutic intervention in human cancers.
Topics: Animals; Antineoplastic Agents; Drug Design; Humans; Indoles; Molecular Targeted Therapy; Neoplasms; Niacinamide; Phenylurea Compounds; Piperidines; Proto-Oncogene Mas; Proto-Oncogene Proteins c-ret; Pyrroles; Quinazolines; Signal Transduction; Sorafenib; Sunitinib | 2013 |
New drug therapies on the horizon for IBD.
Topics: Animals; Antibodies, Monoclonal; Cell Adhesion Molecules; Humans; Immunization; Inflammatory Bowel Diseases; Piperidines; Pyrimidines; Pyrroles; Tumor Necrosis Factor-alpha | 2012 |
[Janus kinase inhibitors as a new therapeutic principle].
Topics: Arthritis, Rheumatoid; Colitis, Ulcerative; Enzyme Inhibitors; Humans; Janus Kinases; Nitriles; Piperidines; Primary Myelofibrosis; Pyrazoles; Pyrimidines; Pyrroles; Signal Transduction | 2012 |
JAK inhibitor tofacitinib for treating rheumatoid arthritis: from basic to clinical.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Humans; Janus Kinase 3; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Treatment Outcome | 2013 |
Kinase inhibitors for the treatment of rheumatoid arthritis.
Topics: Aminopyridines; Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Morpholines; Oxazines; Piperidines; Protein Kinase Inhibitors; Pyridines; Pyrimidines; Pyrroles; Signal Transduction; Treatment Outcome | 2012 |
Tofacitinib (Xeljanz) for rheumatoid arthritis.
Topics: Animals; Arthritis, Rheumatoid; Humans; Janus Kinase 3; Piperidines; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic | 2013 |
IBD in 2012: Pathogenesis and management of IBD--thinking outside the box.
Topics: Antibodies, Monoclonal, Humanized; Genetic Loci; Humans; Inflammatory Bowel Diseases; Piperidines; Pyrimidines; Pyrroles; Treatment Outcome | 2013 |
Rheumatoid arthritis in 2012: Progress in RA genetics, pathology and therapy.
Topics: Arthritis, Rheumatoid; Disease Management; Enzyme Inhibitors; Genetic Predisposition to Disease; HLA Antigens; Humans; Piperidines; Protein-Tyrosine Kinases; Pyrimidines; Pyrroles | 2013 |
Novel targets for inflammatory bowel disease therapeutics.
Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Cell Adhesion Molecules; Certolizumab Pegol; Colitis, Ulcerative; Crohn Disease; Humans; Immunoglobulin Fab Fragments; Infliximab; Natalizumab; Piperidines; Polyethylene Glycols; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Quinolones; Tumor Necrosis Factor-alpha; Ustekinumab | 2013 |
Small molecules targeting JAKs--a new approach in the treatment of rheumatoid arthritis.
Topics: Administration, Oral; Aminopyridines; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials, Phase III as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Forecasting; Germany; Humans; Janus Kinases; Male; Maximum Tolerated Dose; Molecular Targeted Therapy; Morpholines; Oxazines; Piperidines; Prognosis; Pyridines; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Severity of Illness Index; Treatment Outcome | 2013 |
Targeting kinases: a new approach to treating inflammatory rheumatic diseases.
Topics: Animals; Humans; Intracellular Signaling Peptides and Proteins; Janus Kinase 3; Mitogen-Activated Protein Kinases; Piperidines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrimidines; Pyrroles; Rheumatic Diseases; Syk Kinase | 2013 |
[Pigmentary disorders induced by anticancer agents. Part II: targeted therapies].
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Benzamides; Cetuximab; Dasatinib; ErbB Receptors; Humans; Imatinib Mesylate; Indazoles; Indoles; Ipilimumab; Niacinamide; Phenylurea Compounds; Pigmentation Disorders; Piperazines; Piperidines; Programmed Cell Death 1 Receptor; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Quinazolines; Receptors, Vascular Endothelial Growth Factor; Sorafenib; Sulfonamides; Sunitinib; Thiazoles | 2013 |
A pharmacokinetic and clinical assessment of tofacitinib for the treatment of rheumatoid arthritis.
Topics: Administration, Oral; Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Cytochrome P-450 CYP3A; Humans; Janus Kinase 1; Janus Kinase 3; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles | 2013 |
Janus kinase inhibition with tofacitinib: changing the face of inflammatory bowel disease treatment.
Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Colitis, Ulcerative; Crohn Disease; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Inflammatory Bowel Diseases; Janus Kinases; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; United States; United States Food and Drug Administration | 2013 |
Tofacitinib: a review of its use in adult patients with rheumatoid arthritis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Treatment Outcome | 2013 |
Involvement of JAK/STAT signaling in the pathogenesis of inflammatory bowel disease.
Topics: Animals; Humans; Inflammatory Bowel Diseases; Janus Kinases; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Signal Transduction; STAT Transcription Factors | 2013 |
Tofacitinib in kidney transplantation.
Topics: Animals; Clinical Trials as Topic; Graft Rejection; Graft Survival; Humans; Immunosuppressive Agents; Janus Kinase 3; Kidney Transplantation; Molecular Targeted Therapy; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Time Factors | 2013 |
Tofacitinab in renal transplantation.
Topics: Graft Rejection; Humans; Immunosuppressive Agents; Infections; Kidney Transplantation; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Risk Factors | 2013 |
The effectiveness of tofacitinib, a novel Janus kinase inhibitor, in the treatment of rheumatoid arthritis: a systematic review and meta-analysis.
Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Inflammation; Janus Kinases; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Risk; Treatment Outcome; Tumor Necrosis Factor-alpha | 2013 |
Tofacitinib for treatment of rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Janus Kinase 3; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Treatment Outcome | 2013 |
[JAK inhibitor].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Janus Kinases; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Signal Transduction | 2013 |
Jakpot! New small molecules in autoimmune and inflammatory diseases.
Topics: Animals; Autoimmune Diseases; Cytokines; Humans; Immunosuppressive Agents; Inflammation; Janus Kinases; Mice; Nitriles; Piperidines; Protein Kinase Inhibitors; Psoriasis; Pyrazoles; Pyrimidines; Pyrroles; Signal Transduction | 2014 |
Efficacy and safety of tofacitinib in the treatment of rheumatoid arthritis: a systematic review and meta-analysis.
Topics: Adalimumab; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Janus Kinase 3; Piperidines; Pyrimidines; Pyrroles; Treatment Outcome | 2013 |
Comparative pathophysiology, toxicology, and human cancer risk assessment of pharmaceutical-induced hibernoma.
Topics: Animals; Benzazepines; Carcinogenicity Tests; Disease Models, Animal; Humans; Hydromorphone; Lipoma; Mutagenicity Tests; Neoplasms; Phentolamine; Piperidines; Pyrimidines; Pyrroles; Quinoxalines; Rats; Risk Assessment; Varenicline | 2013 |
Therapeutic targeting of the Jak/STAT pathway.
Topics: Animals; Autoimmune Diseases; Cytokines; Disease Models, Animal; Humans; Janus Kinases; Nitriles; Piperidines; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; Pyrroles; Signal Transduction; STAT Transcription Factors | 2014 |
Targeting the Janus kinases in rheumatoid arthritis: focus on tofacitinib.
Topics: Animals; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Janus Kinases; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles | 2014 |
Efficacy, safety and tolerability of tofacitinib in patients with an inadequate response to disease modifying anti-rheumatic drugs: a meta-analysis of randomized double-blind controlled studies.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Humans; Piperidines; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Treatment Failure | 2013 |
Tofacitinib: The First Janus Kinase (JAK) inhibitor for the treatment of rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Aryl Hydrocarbon Hydroxylases; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Drug Interactions; Humans; Janus Kinases; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Treatment Outcome | 2013 |
The biology of IL-15: implications for cancer therapy and the treatment of autoimmune disorders.
Topics: Alopecia Areata; Animals; Antibodies, Monoclonal; Autoimmune Diseases; Humans; Interleukin-15; Leukemia-Lymphoma, Adult T-Cell; Neoplasms; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Receptors, Interleukin-15; Signal Transduction | 2013 |
Janus kinases: an ideal target for the treatment of autoimmune diseases.
Topics: Animals; Autoimmune Diseases; Cytokines; Humans; Janus Kinases; Nitriles; Piperidines; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; Pyrroles; Signal Transduction; STAT Transcription Factors | 2013 |
[Targeted therapies, prognostic and predictive factors in endocrine oncology].
Topics: Antineoplastic Agents; Carcinoma, Neuroendocrine; Clinical Trials, Phase III as Topic; Disease-Free Survival; Endocrine Gland Neoplasms; Everolimus; Humans; Indoles; Molecular Targeted Therapy; Neuroendocrine Tumors; Niacinamide; Pancreatic Neoplasms; Phenylurea Compounds; Piperidines; Prognosis; Pyrroles; Quinazolines; Sirolimus; Sorafenib; Sunitinib; Thyroid Neoplasms; Treatment Outcome | 2013 |
Tofacitinib for acute rheumatoid arthritis patients who have had an inadequate response to disease-modifying antirheumatic drug (DMARD): a systematic review and meta-analysis.
Topics: Acute Disease; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Female; Humans; Male; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Remission Induction; Treatment Outcome | 2014 |
Efficacy of conventional synthetic disease-modifying antirheumatic drugs, glucocorticoids and tofacitinib: a systematic literature review informing the 2013 update of the EULAR recommendations for management of rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Evidence-Based Medicine; Glucocorticoids; Humans; Methotrexate; Piperidines; Practice Guidelines as Topic; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Treatment Outcome | 2014 |
Discovery and development of Janus kinase (JAK) inhibitors for inflammatory diseases.
Topics: Animals; Anti-Inflammatory Agents; Antirheumatic Agents; Autoimmune Diseases; Clinical Trials as Topic; Cytokines; Humans; Inflammation; Inflammatory Bowel Diseases; Janus Kinases; Piperidines; Protein Conformation; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Signal Transduction | 2014 |
Kinase inhibitors: the next generation of therapies in the treatment of rheumatoid arthritis.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Design; Humans; Janus Kinases; Molecular Targeted Therapy; Piperidines; Protein Kinase Inhibitors; Protein Kinases; Pyrimidines; Pyrroles; Signal Transduction | 2014 |
[New therapies for rheumatoid arthritis].
Topics: Abatacept; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Piperidines; Pyrimidines; Pyrroles; Rituximab; Treatment Outcome; Tumor Necrosis Factor-alpha | 2014 |
Therapeutic potential of tyrosine kinase 2 in autoimmunity.
Topics: Adaptive Immunity; Autoimmune Diseases; Autoimmunity; Dendritic Cells; Drug Design; Genetic Predisposition to Disease; Humans; Immunity, Cellular; Lymphocyte Subsets; Macrophages; Molecular Targeted Therapy; Neutrophils; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; TYK2 Kinase | 2014 |
Safety and efficacy of tofacitinib, an oral janus kinase inhibitor, for the treatment of rheumatoid arthritis in open-label, longterm extension studies.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Female; Humans; Janus Kinase 3; Male; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles | 2014 |
In the pipeline for psoriasis: upcoming psoriasis treatments.
Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Arthritis, Psoriatic; Certolizumab Pegol; Etanercept; Humans; Immunoglobulin Fab Fragments; Immunoglobulin G; Immunosuppressive Agents; Infliximab; Interleukin-12 Subunit p40; Janus Kinases; Nitriles; Piperidines; Polyethylene Glycols; Protein Kinase Inhibitors; Psoriasis; Pyrazoles; Pyrimidines; Pyrroles; Receptors, Interleukin-17; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha; Ustekinumab | 2014 |
[Tofacitinib].
Topics: Administration, Oral; Arthritis, Rheumatoid; Clinical Trials, Phase III as Topic; Drug Approval; Europe; Humans; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Treatment Outcome | 2014 |
Risk of tuberculosis in patients with chronic immune-mediated inflammatory diseases treated with biologics and tofacitinib: a systematic review and meta-analysis of randomized controlled trials and long-term extension studies.
Topics: Biological Products; Humans; Incidence; Latent Tuberculosis; Piperidines; Pyrimidines; Pyrroles; Risk; Tuberculosis | 2014 |
JAK inhibitors: treatment efficacy and safety profile in patients with psoriasis.
Topics: Clinical Trials as Topic; Gene Expression Regulation; Humans; Janus Kinase 1; Janus Kinase 2; Janus Kinase 3; Molecular Targeted Therapy; Nitriles; Piperidines; Protein Kinase Inhibitors; Psoriasis; Pyrazoles; Pyrimidines; Pyrroles; Signal Transduction; Treatment Outcome | 2014 |
Analysis of infections and all-cause mortality in phase II, phase III, and long-term extension studies of tofacitinib in patients with rheumatoid arthritis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Infections; Longitudinal Studies; Male; Methotrexate; Middle Aged; Piperidines; Prevalence; Proportional Hazards Models; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Retrospective Studies; Risk Factors; Survival Rate; Treatment Outcome; Young Adult | 2014 |
Systematic review of tofacitinib: a new drug for the management of rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Methotrexate; Piperidines; Pyrimidines; Pyrroles; Treatment Outcome | 2014 |
Update on Janus kinase antagonists in inflammatory bowel disease.
Topics: Animals; Dyslipidemias; Humans; Inflammatory Bowel Diseases; Janus Kinases; Opportunistic Infections; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Signal Transduction | 2014 |
Small molecule inhibitors in veterinary oncology practice.
Topics: Animals; Benzamides; Cat Diseases; Cats; Dog Diseases; Dogs; Indoles; Neoplasms; Piperidines; Protein Kinase Inhibitors; Pyridines; Pyrroles; Thiazoles | 2014 |
[Pharmacology profile and clinical findings of tofacitinib citrate (Xeljanz® tablet 5 mg)].
Topics: Administration, Oral; Animals; Humans; Mice; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Rats; Rheumatic Diseases | 2014 |
Efficacy and safety of tofacitinib for active rheumatoid arthritis with an inadequate response to methotrexate or disease-modifying antirheumatic drugs: a meta-analysis of randomized controlled trials.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Humans; Janus Kinases; Methotrexate; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Treatment Outcome | 2014 |
Therapeutic development in psoriasis.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Clinical Trials as Topic; Humans; Immunologic Factors; Interleukin-23; Phosphodiesterase Inhibitors; Piperidines; Protein Kinase Inhibitors; Psoriasis; Pyrimidines; Pyrroles; Thalidomide; Treatment Outcome | 2014 |
Lipid profile changes in patients with chronic inflammatory arthritis treated with biologic agents and tofacitinib in randomized clinical trials: a systematic review and meta-analysis.
Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Arthritis, Rheumatoid; Biological Products; Chronic Disease; Female; Humans; Lipids; Male; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Spondylarthritis; Treatment Outcome | 2015 |
Efficacy and safety of angiogenesis inhibitors in advanced non-small cell lung cancer: a systematic review and meta-analysis.
Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Bevacizumab; Carcinoma, Non-Small-Cell Lung; Disease-Free Survival; Hemorrhage; Humans; Indazoles; Indoles; Lung Neoplasms; Niacinamide; Odds Ratio; Phenylurea Compounds; Piperidines; Pyrimidines; Pyrroles; Quinazolines; Ramucirumab; Randomized Controlled Trials as Topic; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Sorafenib; Sulfonamides; Sunitinib; Thrombocytopenia; Treatment Outcome; Vascular Endothelial Growth Factor A | 2015 |
Current and future oral systemic therapies for psoriasis.
Topics: Acitretin; Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites; Cyclosporine; Fumarates; Humans; Hydroxyurea; Immunosuppressive Agents; Isoxazoles; Keratolytic Agents; Leflunomide; Methotrexate; Mycophenolic Acid; Piperidines; Protein Kinase Inhibitors; Psoriasis; Pyrimidines; Pyrroles; Sulfasalazine; Thalidomide; Thioguanine | 2015 |
Current and emerging biologics for ulcerative colitis.
Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Biological Factors; Cell Adhesion Molecules; Colitis, Ulcerative; Humans; Infliximab; Janus Kinases; Piperidines; Pyrimidines; Pyrroles | 2015 |
Tofacitinib for the treatment of moderate-to-severe psoriasis.
Topics: Animals; Clinical Trials as Topic; Disease Progression; Humans; Janus Kinases; Molecular Targeted Therapy; Piperidines; Protein Kinase Inhibitors; Psoriasis; Pyrimidines; Pyrroles; STAT Transcription Factors | 2015 |
New systemic therapies for psoriasis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Biological Factors; Humans; Piperidines; Protein Kinase Inhibitors; Psoriasis; Pyrimidines; Pyrroles; Thalidomide | 2015 |
Tofacitinib, an oral Janus kinase inhibitor: analysis of malignancies across the rheumatoid arthritis clinical development programme.
Topics: Administration, Oral; Adolescent; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Dose-Response Relationship, Drug; Female; Humans; Incidence; Janus Kinase 3; Male; Middle Aged; Multicenter Studies as Topic; Neoplasms; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Young Adult | 2016 |
Comparative efficacy and safety of tofacitinib, with or without methotrexate, in patients with active rheumatoid arthritis: a Bayesian network meta-analysis of randomized controlled trials.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Bayes Theorem; Drug Therapy, Combination; Humans; Methotrexate; Piperidines; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Treatment Outcome | 2015 |
Current State of Immunosuppression: Past, Present, and Future.
Topics: Abatacept; Alemtuzumab; Animals; Antibodies, Monoclonal, Humanized; Azathioprine; Bone Marrow Transplantation; Calcineurin Inhibitors; Cyclosporine; Disease Models, Animal; Everolimus; Heart Transplantation; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Kidney Transplantation; Lung Transplantation; Mycophenolic Acid; Piperidines; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Sirolimus; Tacrolimus | 2015 |
Recent progress and perspective in JAK inhibitors for rheumatoid arthritis: from bench to bedside.
Topics: Arthritis, Rheumatoid; Humans; Inflammation; Janus Kinase 1; Janus Kinase 3; Methotrexate; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; STAT1 Transcription Factor; Translational Research, Biomedical; Tumor Necrosis Factor-alpha | 2015 |
Emerging Oral Immunomodulators for the Treatment of Psoriasis: A Review of Phase III Clinical Trials for Apremilast and Tofacitinib.
Topics: Administration, Oral; Clinical Trials, Phase III as Topic; Humans; Immunologic Factors; Phosphodiesterase 4 Inhibitors; Piperidines; Protein Kinase Inhibitors; Psoriasis; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Severity of Illness Index; Thalidomide | 2015 |
[Anti-angiogenesis and molecular targeted therapies].
Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Humans; Indoles; Molecular Targeted Therapy; Neoplasms; Niacinamide; Oligonucleotides; Phenylurea Compounds; Piperidines; Protein Kinase Inhibitors; Pyrroles; Quinazolines; Sorafenib; Sunitinib; Vascular Endothelial Growth Factor A | 2015 |
Tuberculosis and other opportunistic infections in tofacitinib-treated patients with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Humans; Immunocompromised Host; Immunosuppressive Agents; Incidence; Janus Kinase 3; Opportunistic Infections; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Risk Assessment; Tuberculosis | 2016 |
Treatment of advanced thyroid cancer: role of molecularly targeted therapies.
Topics: Anilides; Antineoplastic Agents; Axitinib; Carcinoma, Neuroendocrine; DNA Mutational Analysis; Drug Approval; Humans; Imidazoles; Indazoles; Indoles; MAP Kinase Signaling System; Molecular Targeted Therapy; Niacinamide; Oligonucleotides; Phenylurea Compounds; Phosphatidylinositol 3-Kinases; Piperidines; Proto-Oncogene Proteins c-ret; Pyridines; Pyrimidines; Pyrroles; Quinazolines; Quinolines; Sorafenib; Sulfonamides; Sunitinib; Thyroid Neoplasms; United States; United States Food and Drug Administration; Vascular Endothelial Growth Factor A | 2015 |
Pharmacology Update on Chronic Obstructive Pulmonary Disease, Rheumatoid Arthritis, and Major Depression.
Topics: Anti-Anxiety Agents; Arthritis, Rheumatoid; Benzyl Alcohols; Bronchodilator Agents; Chlorobenzenes; Depressive Disorder; Fluticasone; Humans; Nursing Process; Piperazines; Piperidines; Protein Kinase Inhibitors; Pulmonary Disease, Chronic Obstructive; Pyrimidines; Pyrroles; Sulfides; United States; Vortioxetine | 2015 |
JAK inhibition using tofacitinib for inflammatory bowel disease treatment: a hub for multiple inflammatory cytokines.
Topics: Adaptive Immunity; Animals; Cytokines; Humans; Immunity, Innate; Inflammatory Bowel Diseases; Janus Kinases; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Signal Transduction | 2016 |
Systematic review and meta-analysis of serious infections with tofacitinib and biologic disease-modifying antirheumatic drug treatment in rheumatoid arthritis clinical trials.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Communicable Diseases; Humans; Janus Kinase 3; Piperidines; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Treatment Outcome | 2015 |
Comparative efficacy and safety of tocilizumab, rituximab, abatacept and tofacitinib in patients with active rheumatoid arthritis that inadequately responds to tumor necrosis factor inhibitors: a Bayesian network meta-analysis of randomized controlled tri
Topics: Abatacept; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Bayes Theorem; Biological Products; Drug Substitution; Humans; Network Meta-Analysis; Odds Ratio; Piperidines; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Rituximab; Treatment Failure; Tumor Necrosis Factor-alpha | 2016 |
[Tyrosine kinase inhibiting the VEGF pathway and elderly people: Tolerance, pre-treatment assessment and side effects management].
Topics: Aged; Aged, 80 and over; Angiogenesis Inhibitors; Axitinib; Fatigue; Humans; Imidazoles; Indazoles; Indoles; Kidney; Neovascularization, Pathologic; Niacinamide; Phenylurea Compounds; Piperidines; Protein Kinase Inhibitors; Pyridines; Pyrroles; Quinazolines; Receptors, Vascular Endothelial Growth Factor; Sorafenib; Sunitinib | 2016 |
Profile of tofacitinib citrate and its potential in the treatment of moderate-to-severe chronic plaque psoriasis.
Topics: Chronic Disease; Clinical Trials as Topic; Humans; Janus Kinase 3; Piperidines; Protein Kinase Inhibitors; Psoriasis; Pyrimidines; Pyrroles | 2016 |
Novel Oral Therapies for Psoriasis and Psoriatic Arthritis.
Topics: Adamantane; Adenosine; Adenosine A3 Receptor Antagonists; Administration, Oral; Arthritis, Psoriatic; Azetidines; Biological Factors; Biological Therapy; Clinical Trials as Topic; Humans; Isonicotinic Acids; Janus Kinases; Niacinamide; Phosphodiesterase 4 Inhibitors; Piperidines; Protein Kinase Inhibitors; Psoriasis; Purines; Pyrazoles; Pyrimidines; Pyrroles; Receptors, Lysosphingolipid; rho-Associated Kinases; Sulfonamides; Thalidomide; Thiazoles | 2016 |
Interleukin 21 as a new possible player in pemphigus: Is it a suitable target?
Topics: Animals; Antibodies, Monoclonal; Humans; Immunity, Cellular; Interleukins; Molecular Targeted Therapy; Pemphigus; Piperidines; Pyrimidines; Pyrroles | 2016 |
An Update on Calcineurin Inhibitor-Free Regimens: The Need Persists, but the Landscape has Changed.
Topics: Abatacept; Animals; Calcineurin Inhibitors; Drug Therapy, Combination; Graft Rejection; Graft Survival; Humans; Immunosuppressive Agents; Molecular Targeted Therapy; Organ Transplantation; Piperidines; Pyrimidines; Pyrroles; Quinazolines; Risk Assessment; Risk Factors; Signal Transduction; Time Factors; Treatment Outcome | 2016 |
Effects of tofacitinib and other DMARDs on lipid profiles in rheumatoid arthritis: implications for the rheumatologist.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Lipids; Piperidines; Pyrimidines; Pyrroles; Rheumatology | 2016 |
Relevance of involvement of tofacitinib in T cell subsets to clinical courses and adverse events in patients with rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Herpes Zoster; Humans; Janus Kinases; Male; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; T-Lymphocyte Subsets | 2015 |
Tofacitinib in ulcerative colitis.
Topics: Animals; Arthritis, Rheumatoid; Autoimmunity; Colitis, Ulcerative; Cytokines; Humans; Janus Kinases; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Signal Transduction | 2016 |
Biologics or tofacitinib for rheumatoid arthritis in incomplete responders to methotrexate or other traditional disease-modifying anti-rheumatic drugs: a systematic review and network meta-analysis.
Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Certolizumab Pegol; Etanercept; Humans; Infliximab; Interleukin 1 Receptor Antagonist Protein; Methotrexate; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Rituximab | 2016 |
Tofacitinib for the treatment of ulcerative colitis.
Topics: Administration, Oral; Animals; Colitis, Ulcerative; Humans; Intestinal Mucosa; Janus Kinases; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Severity of Illness Index; Signal Transduction; STAT Transcription Factors | 2016 |
Benefit and Risk of Tofacitinib in the Treatment of Rheumatoid Arthritis: A Focus on Herpes Zoster.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Herpes Zoster; Humans; Janus Kinases; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles | 2016 |
Progress in understanding the safety and efficacy of Janus kinase inhibitors for treatment of rheumatoid arthritis.
Topics: Administration, Oral; Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Azetidines; Clinical Trials as Topic; Heterocyclic Compounds, 2-Ring; Humans; Janus Kinase 1; Piperidines; Protein Kinase Inhibitors; Purines; Pyrazoles; Pyrimidines; Pyrroles; Sulfonamides; Treatment Outcome; Valine | 2016 |
Tofacitinib for the treatment of psoriasis.
Topics: Biomarkers; Drug Administration Schedule; Humans; Piperidines; Protein Kinase Inhibitors; Psoriasis; Pyrimidines; Pyrroles | 2016 |
[Guidelines for the management of rheumatoid arthritis].
Topics: Abatacept; Algorithms; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Drug Substitution; Drug Therapy, Combination; Humans; Japan; Methotrexate; Piperidines; Practice Guidelines as Topic; Pyrimidines; Pyrroles | 2016 |
[Tofacitinib for the treatment of rheumatoid arthritis].
Topics: Administration, Ophthalmic; Antirheumatic Agents; Arthritis, Rheumatoid; Azetidines; Clinical Trials as Topic; Drug Discovery; Humans; Janus Kinases; Lymphocytes; Molecular Targeted Therapy; Piperidines; Purines; Pyrazoles; Pyrimidines; Pyrroles; Signal Transduction; Sulfonamides; Treatment Outcome | 2016 |
Relation between disease modifying anti-rheumatic drugs and herpes zoster in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Follow-Up Studies; Herpes Zoster; Humans; Incidence; Janus Kinases; Japan; Molecular Targeted Therapy; Piperidines; Product Surveillance, Postmarketing; Pyrimidines; Pyrroles | 2016 |
Efficacy and safety of tofacitinib in patients with active rheumatoid arthritis: review of key Phase 2 studies.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials, Phase II as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Janus Kinases; Male; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Remission Induction; Treatment Outcome | 2016 |
Next-Generation Therapeutics for Inflammatory Bowel Disease.
Topics: Antibodies, Monoclonal, Humanized; Biological Products; Cell Adhesion Molecules; Gastrointestinal Agents; Humans; Immunoglobulins; Indans; Inflammatory Bowel Diseases; Mucoproteins; Oligonucleotides; Oxadiazoles; Piperidines; Pyrimidines; Pyrroles; Tumor Necrosis Factor-alpha; Ustekinumab | 2016 |
Recent Progress in JAK Inhibitors for the Treatment of Rheumatoid Arthritis.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Azetidines; Heterocyclic Compounds, 3-Ring; Humans; Janus Kinases; Molecular Targeted Therapy; Piperidines; Protein Kinase Inhibitors; Purines; Pyrazoles; Pyridines; Pyrimidines; Pyrroles; Sulfonamides; Triazoles | 2016 |
Recent trends and future directions for the medical treatment of ulcerative colitis.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Budesonide; Calcineurin Inhibitors; Colitis, Ulcerative; Drug Therapy, Combination; Drugs, Chinese Herbal; Forecasting; Gastrointestinal Agents; Glucocorticoids; Humans; Phenylalanine; Piperidines; Pyrimidines; Pyrroles; Quinazolinones; Tumor Necrosis Factor-alpha | 2016 |
Lessons Learned From Trials Targeting Cytokine Pathways in Patients With Inflammatory Bowel Diseases.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Cytokines; Humans; Inflammatory Bowel Diseases; Interleukin-23; Janus Kinases; Lysophospholipids; Molecular Targeted Therapy; Oligonucleotides; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Signal Transduction; Smad7 Protein; Sphingosine; Th17 Cells; Transforming Growth Factor beta; Ustekinumab | 2017 |
Biologic or tofacitinib monotherapy for rheumatoid arthritis in people with traditional disease-modifying anti-rheumatic drug (DMARD) failure: a Cochrane Systematic Review and network meta-analysis (NMA).
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Certolizumab Pegol; Disease Progression; Etanercept; Humans; Interleukin 1 Receptor Antagonist Protein; Methotrexate; Network Meta-Analysis; Piperidines; Pyrimidines; Pyrroles; Rituximab; Treatment Failure | 2016 |
New targets in psoriatic arthritis.
Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Psoriatic; Cyclophosphamide; Etanercept; Humans; Infliximab; Methotrexate; Molecular Targeted Therapy; Phosphodiesterase 4 Inhibitors; Piperidines; Psoriasis; Pyrimidines; Pyrroles; Sulfasalazine; Thalidomide; Ustekinumab | 2016 |
Tofacitinib Versus Biologic Treatments in Patients With Active Rheumatoid Arthritis Who Have Had an Inadequate Response to Tumor Necrosis Factor Inhibitors: Results From a Network Meta-analysis.
Topics: Abatacept; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Drug Therapy, Combination; Humans; Male; Methotrexate; Network Meta-Analysis; Piperidines; Pyrimidines; Pyrroles; Rituximab; Treatment Failure; Treatment Outcome; Tumor Necrosis Factor-alpha | 2016 |
Vaccines and Disease-Modifying Antirheumatic Drugs: Practical Implications for the Rheumatologist.
Topics: Abatacept; Antirheumatic Agents; Contraindications; Drug Interactions; Herpes Zoster Vaccine; Humans; Immunocompromised Host; Immunogenicity, Vaccine; Influenza Vaccines; Methotrexate; Piperidines; Pneumococcal Vaccines; Pyrimidines; Pyrroles; Rheumatic Diseases; Rheumatologists; Rituximab; Vaccines; Vaccines, Attenuated; Yellow Fever Vaccine | 2017 |
Malignancy and Janus Kinase Inhibition.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Incidence; Janus Kinases; Neoplasms; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Skin Neoplasms | 2017 |
Janus kinase inhibition for immunosuppression in solid organ transplantation: Is there a role in complex immunologic challenges?
Topics: Graft Rejection; Humans; Immunosuppression Therapy; Interleukin Receptor Common gamma Subunit; Janus Kinase 3; Kidney Transplantation; Molecular Targeted Therapy; Monitoring, Physiologic; Piperidines; Pyrimidines; Pyrroles; Signal Transduction | 2017 |
Risk of serious adverse effects of biological and targeted drugs in patients with rheumatoid arthritis: a systematic review meta-analysis.
Topics: Abatacept; Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Certolizumab Pegol; Etanercept; Humans; Network Meta-Analysis; Piperidines; Poisson Distribution; Pyrimidines; Pyrroles; Regression Analysis; Risk; Rituximab | 2017 |
Janus kinase (JAK) inhibitors for the treatment of skin and hair disorders: a review of literature.
Topics: Alopecia Areata; Azetidines; Dermatitis, Atopic; Humans; Janus Kinase Inhibitors; Janus Kinases; Nitriles; Piperidines; Psoriasis; Purines; Pyrazoles; Pyrimidines; Pyrroles; Skin Diseases; Sulfonamides; Vitiligo | 2017 |
Kinase Inhibitors in Multitargeted Cancer Therapy.
Topics: Anilides; Crizotinib; Humans; Imatinib Mesylate; Imidazoles; Indoles; Neoplasms; Niacinamide; Phenylurea Compounds; Piperidines; Protein Kinase Inhibitors; Pyrazoles; Pyridazines; Pyridines; Pyrroles; Quinazolines; Receptor Protein-Tyrosine Kinases; Sorafenib; Sunitinib | 2017 |
Tofacitinib, an Oral Janus Kinase Inhibitor: Perspectives in Dermatology.
Topics: Administration, Oral; Alopecia Areata; Dermatitis, Atopic; Humans; Janus Kinases; Piperidines; Protein Kinase Inhibitors; Psoriasis; Pyrimidines; Pyrroles; Signal Transduction; Skin Diseases; Vitiligo | 2017 |
Therapeutic Potential of Targeting the Th17/Treg Axis in Autoimmune Disorders.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Autoimmune Diseases; Forkhead Transcription Factors; Gene Expression Regulation; Humans; Immunologic Factors; Inflammation; Interleukin-17; Nuclear Receptor Subfamily 1, Group F, Member 3; Piperidines; Pyrimidines; Pyrroles; Signal Transduction; T-Lymphocytes, Regulatory; Th17 Cells; Ustekinumab | 2017 |
JAK inhibitors in dermatology: The promise of a new drug class.
Topics: Alopecia Areata; Anti-Inflammatory Agents; Azetidines; Clinical Trials as Topic; Dermatitis, Atopic; Dermatologic Agents; Humans; Janus Kinases; Molecular Targeted Therapy; Nitriles; Piperidines; Protein Kinase Inhibitors; Psoriasis; Purines; Pyrazoles; Pyrimidines; Pyrroles; Signal Transduction; Skin Diseases; Sulfonamides; Vitiligo | 2017 |
The Future of Janus Kinase Inhibitors in Inflammatory Bowel Disease.
Topics: Animals; Cytokines; Humans; Inflammatory Bowel Diseases; Janus Kinase Inhibitors; Janus Kinases; Mutation; Piperidines; Pyrimidines; Pyrroles; Signal Transduction; STAT Transcription Factors | 2017 |
JAK inhibition in inflammatory bowel disease.
Topics: Animals; Arthritis, Rheumatoid; Clinical Trials as Topic; Humans; Inflammatory Bowel Diseases; Janus Kinases; Molecular Targeted Therapy; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Risk Assessment; Signal Transduction; STAT Transcription Factors | 2017 |
Janus kinase inhibitors in dermatology: A systematic review.
Topics: Alopecia Areata; Anti-Inflammatory Agents; Antineoplastic Agents; Azetidines; Dermatologic Agents; Drug Eruptions; Humans; Janus Kinases; Molecular Targeted Therapy; Nitriles; Piperidines; Protein Kinase Inhibitors; Psoriasis; Purines; Pyrazoles; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Signal Transduction; Skin Diseases; Sulfonamides | 2017 |
The emerging safety profile of JAK inhibitors in rheumatic disease.
Topics: Azetidines; Humans; Infections; Janus Kinases; Neoplasms; Piperidines; Protein Kinase Inhibitors; Purines; Pyrazoles; Pyrimidines; Pyrroles; Rheumatic Diseases; Signal Transduction; Sulfonamides | 2017 |
Biologics or tofacitinib for people with rheumatoid arthritis unsuccessfully treated with biologics: a systematic review and network meta-analysis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Bayes Theorem; Biological Products; Disease Progression; Humans; Methotrexate; Neoplasms; Network Meta-Analysis; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Treatment Failure | 2017 |
Risks of malignancies related to tofacitinib and biological drugs in rheumatoid arthritis: Systematic review, meta-analysis, and network meta-analysis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Humans; Neoplasms; Network Meta-Analysis; Piperidines; Pyrimidines; Pyrroles; Risk | 2017 |
Medical and Maintenance Treatments for Vitiligo.
Topics: Administration, Cutaneous; Adrenal Cortex Hormones; alpha-MSH; Anti-Bacterial Agents; Calcineurin Inhibitors; Dinoprostone; Humans; Immunosuppressive Agents; Low-Level Light Therapy; Methotrexate; Minocycline; Oxytocics; Phototherapy; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Ultraviolet Therapy; Vitamin D; Vitiligo | 2017 |
Tofacitinib in the Treatment of Rheumatoid Arthritis and Chronic Plaque Psoriasis.
Topics: Arthritis, Rheumatoid; Clinical Trials, Phase III as Topic; Humans; Janus Kinase 3; Piperidines; Protein Kinase Inhibitors; Psoriasis; Pyrimidines; Pyrroles; Treatment Outcome | 2017 |
Efficacy of glucocorticoids, conventional and targeted synthetic disease-modifying antirheumatic drugs: a systematic literature review informing the 2016 update of the EULAR recommendations for the management of rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Azetidines; Drug Therapy, Combination; Glucocorticoids; Humans; Methotrexate; Piperidines; Practice Guidelines as Topic; Purines; Pyrazoles; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Sulfonamides | 2017 |
The use of kinase inhibitors in solid organ transplantation.
Topics: Aminopyridines; Humans; Immunosuppressive Agents; Indoles; Morpholines; Organ Transplantation; Oxazines; Piperidines; Protein Kinase Inhibitors; Pyridines; Pyrimidines; Pyrroles; Quinazolines; Sunitinib; Syk Kinase | 2017 |
Quantitative Evaluations of Time-Course and Treatment Effects of Systemic Agents for Psoriasis: A Model-Based Meta-Analysis.
Topics: Dose-Response Relationship, Drug; Humans; Models, Statistical; Piperidines; Protein Kinase Inhibitors; Psoriasis; Pyrimidines; Pyrroles; Severity of Illness Index; Time Factors; Treatment Outcome | 2017 |
Biologics or tofacitinib for people with rheumatoid arthritis naive to methotrexate: a systematic review and network meta-analysis.
Topics: Abatacept; Adalimumab; Adult; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Bayes Theorem; Biological Products; Etanercept; Humans; Infliximab; Methotrexate; Methylprednisolone; Network Meta-Analysis; Piperidines; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Rituximab | 2017 |
Emerging treatments for ulcerative colitis: a systematic review.
Topics: Andrographis paniculata; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Colitis, Ulcerative; Gastrointestinal Agents; Humans; Induction Chemotherapy; Mesalamine; Piperidines; Plant Extracts; Pyrimidines; Pyrroles; Remission Induction | 2017 |
2017 American College of Rheumatology/American Association of Hip and Knee Surgeons Guideline for the Perioperative Management of Antirheumatic Medication in Patients With Rheumatic Diseases Undergoing Elective Total Hip or Total Knee Arthroplasty.
Topics: Antirheumatic Agents; Arthritis, Juvenile; Arthritis, Psoriatic; Arthritis, Rheumatoid; Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Elective Surgical Procedures; Glucocorticoids; Humans; Lupus Erythematosus, Systemic; Perioperative Care; Piperidines; Pyrimidines; Pyrroles; Rheumatic Diseases; Rheumatology; Spondylarthritis; Spondylitis, Ankylosing; Surgeons; United States | 2017 |
Systematic Literature Review and Meta-analysis of Tumor Necrosis Factor-Alpha Experienced Rheumatoid Arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Humans; Piperidines; Pyrimidines; Pyrroles; Treatment Outcome; Tumor Necrosis Factor-alpha | 2017 |
A review of tofacitinib efficacy in rheumatoid arthritis patients who have had an inadequate response or intolerance to methotrexate.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Janus Kinase Inhibitors; Methotrexate; Piperidines; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Treatment Outcome | 2017 |
Targeting Specific Immunologic Pathways in Crohn's Disease.
Topics: Antibodies, Monoclonal, Humanized; Cell Adhesion Molecules; Cell Movement; Crohn Disease; Endothelium, Vascular; Gastrointestinal Agents; Humans; Immunologic Factors; Integrins; Interleukin-12; Interleukin-12 Subunit p40; Interleukin-23; Janus Kinase Inhibitors; Janus Kinases; Leukocytes; Natalizumab; Piperidines; Pyrimidines; Pyrroles; Signal Transduction; Th1 Cells; Th17 Cells; Ustekinumab | 2017 |
Janus Kinase Antagonists and Other Novel Small Molecules for the Treatment of Crohn's Disease.
Topics: B-Lymphocytes; Colitis, Ulcerative; Crohn Disease; Humans; Indans; Janus Kinase 1; Janus Kinase Inhibitors; Oligonucleotides; Oxadiazoles; Piperidines; Pyridines; Pyrimidines; Pyrroles; Receptors, Lysosphingolipid; Smad7 Protein; T-Lymphocytes; Triazoles | 2017 |
Two new drugs for rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Azetidines; Humans; Piperidines; Purines; Pyrazoles; Pyrimidines; Pyrroles; Sulfonamides | 2017 |
Small molecule therapy for managing moderate to severe psoriatic arthritis.
Topics: Antirheumatic Agents; Arthritis, Psoriatic; Humans; Piperidines; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Severity of Illness Index; Small Molecule Libraries; Thalidomide; Treatment Outcome | 2017 |
Angiogenesis Inhibitors in NSCLC.
Topics: Adenocarcinoma; Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Carcinoma, Non-Small-Cell Lung; Clinical Trials, Phase III as Topic; Disease-Free Survival; Docetaxel; Humans; Indoles; Lung Neoplasms; Neovascularization, Pathologic; Niacinamide; Phenylurea Compounds; Piperidines; Pyrroles; Quinazolines; Ramucirumab; Sorafenib; Sunitinib; Taxoids | 2017 |
Tofacitinib in psoriatic arthritis.
Topics: Animals; Arthritis, Psoriatic; Clinical Trials as Topic; Humans; Janus Kinases; Piperidines; Protein Kinase Inhibitors; Psoriasis; Pyrimidines; Pyrroles | 2017 |
[Systemic treatment of vitiligo : Balance and current developments].
Topics: alpha-MSH; Animals; Biomarkers; Combined Modality Therapy; Disease Models, Animal; Humans; Immunosuppressive Agents; Interferon-alpha; Janus Kinases; Nitriles; Piperidines; Pyrazoles; Pyrimidines; Pyrroles; Ultraviolet Therapy; Vitiligo | 2017 |
Tofacitinib in the treatment of active rheumatoid arthritis in adults.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Approval; Drug Therapy, Combination; Humans; Janus Kinases; Molecular Targeted Therapy; Piperidines; Pyrimidines; Pyrroles | 2018 |
[Inhibition of the Janus kinase-signal transducer and activator of transcription is a new treatment modality of rheumatoid arthritis].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Azetidines; Herpes Zoster; Humans; Janus Kinase Inhibitors; Piperidines; Protein Kinase Inhibitors; Purines; Pyrazoles; Pyrimidines; Pyrroles; Sulfonamides | 2017 |
Tofacitinib: A New Oral Therapy for Psoriasis.
Topics: Administration, Oral; Clinical Trials as Topic; Humans; Janus Kinases; Piperidines; Protein Kinase Inhibitors; Psoriasis; Pyrimidines; Pyrroles | 2018 |
Efficacy and safety of tofacitinib for moderate-to-severe plaque psoriasis: a systematic review and meta-analysis of randomized controlled trials.
Topics: Dermatologic Agents; Humans; Janus Kinase Inhibitors; Piperidines; Placebos; Psoriasis; Pyrimidines; Pyrroles; Quality of Life; Randomized Controlled Trials as Topic; Severity of Illness Index; Treatment Outcome | 2018 |
Tofacitinib: A Review in Rheumatoid Arthritis.
Topics: Adalimumab; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Janus Kinases; Methotrexate; Piperidines; Pyrimidines; Pyrroles | 2017 |
Advances in treating psoriasis in the elderly with small molecule inhibitors.
Topics: Adamantane; Azetidines; Clinical Trials as Topic; Humans; Niacinamide; Nitriles; Phosphodiesterase 4 Inhibitors; Piperidines; Psoriasis; Purines; Pyrazoles; Pyrimidines; Pyrroles; Severity of Illness Index; Small Molecule Libraries; Sulfonamides; Thalidomide | 2017 |
Systematic review with network meta-analysis: first- and second-line pharmacotherapy for moderate-severe ulcerative colitis.
Topics: Adult; Antibodies, Monoclonal, Humanized; Biological Factors; Biological Products; Colitis, Ulcerative; Drug Therapy; Humans; Infliximab; Network Meta-Analysis; Piperidines; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Severity of Illness Index; Tumor Necrosis Factor-alpha | 2018 |
Systematic review with network meta-analysis: comparative assessment of tofacitinib and biological therapies for moderate-to-severe ulcerative colitis.
Topics: Adult; Biological Products; Biological Therapy; Colitis, Ulcerative; Double-Blind Method; Humans; Network Meta-Analysis; Piperidines; Pyrimidines; Pyrroles; Severity of Illness Index | 2018 |
Tofacitinib for the Treatment of Severe Alopecia Areata in Adults and Adolescents.
Topics: Administration, Topical; Adolescent; Adult; Algorithms; Alopecia Areata; Autoimmune Diseases; Clinical Trials as Topic; Female; Humans; Janus Kinase Inhibitors; Male; Piperidines; Pyrimidines; Pyrroles | 2018 |
The Impact of Biologics and Tofacitinib on Cardiovascular Risk Factors and Outcomes in Patients with Rheumatic Disease: A Systematic Literature Review.
Topics: Animals; Antirheumatic Agents; Biological Products; Cardiovascular Diseases; Clinical Trials as Topic; Humans; Piperidines; Prospective Studies; Pyrimidines; Pyrroles; Retrospective Studies; Rheumatic Diseases; Risk Factors | 2018 |
[What's new in dermatological therapy?]
Topics: Adalimumab; Anti-Bacterial Agents; Anti-Inflammatory Agents; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Dermatologic Agents; Dermatology; Erlotinib Hydrochloride; Herpes Zoster Vaccine; Humans; Interleukin 1 Receptor Antagonist Protein; Isotretinoin; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Skin Diseases; Trimethoprim, Sulfamethoxazole Drug Combination | 2016 |
Alopecia universalis unresponsive to treatment with tofacinitib: report of a case with a brief review of the literature.
Topics: Alopecia Areata; Humans; Janus Kinase Inhibitors; Male; Piperidines; Psoriasis; Pyrimidines; Pyrroles; Treatment Failure; Young Adult | 2017 |
[Emerging Therapies: What Are Promising in the Near Future?]
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Colitis, Ulcerative; Crohn Disease; Gastrointestinal Agents; Humans; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Tumor Necrosis Factor-alpha; Ustekinumab | 2018 |
Thromboembolism with Janus Kinase (JAK) Inhibitors for Rheumatoid Arthritis: How Real is the Risk?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Azetidines; Clinical Trials as Topic; Humans; Janus Kinase Inhibitors; Piperidines; Purines; Pyrazoles; Pyrimidines; Pyrroles; Risk Factors; Sulfonamides; Thromboembolism | 2018 |
Tofacitinib for Treating Rheumatoid Arthritis After the Failure of Disease-Modifying Anti-rheumatic Drugs: An Evidence Review Group Perspective of a NICE Single Technology Appraisal.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cost-Benefit Analysis; Drug Costs; Drug Resistance; Drug Therapy, Combination; Humans; Methotrexate; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Quality-Adjusted Life Years; Technology Assessment, Biomedical | 2018 |
Positioning Tofacitinib in the Treatment Algorithm of Moderate to Severe Ulcerative Colitis.
Topics: Algorithms; Colitis, Ulcerative; Humans; Piperidines; Prognosis; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Severity of Illness Index | 2018 |
The use of tofacitinib in the treatment of inflammatory bowel disease.
Topics: Humans; Inflammatory Bowel Diseases; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles | 2018 |
Herpes Zoster in Patients Receiving JAK Inhibitors For Ulcerative Colitis: Mechanism, Epidemiology, Management, and Prevention.
Topics: Antiviral Agents; Colitis, Ulcerative; Disease Management; Herpes Zoster; Herpesvirus 3, Human; Humans; Janus Kinase Inhibitors; Janus Kinases; Piperidines; Prognosis; Pyrimidines; Pyrroles | 2018 |
Tofacitinib 5 mg Twice Daily in Patients with Rheumatoid Arthritis and Inadequate Response to Disease-Modifying Antirheumatic Drugs: A Comprehensive Review of Phase 3 Efficacy and Safety.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials, Phase III as Topic; Humans; Janus Kinase Inhibitors; Piperidines; Pyrimidines; Pyrroles; Treatment Outcome | 2019 |
Are Janus Kinase Inhibitors Superior over Classic Biologic Agents in RA Patients?
Topics: Animals; Azetidines; Humans; Janus Kinases; Piperidines; Protein Kinase Inhibitors; Purines; Pyrazoles; Pyrimidines; Pyrroles; Rheumatic Fever; Sulfonamides | 2018 |
[Research progress of JAK-3 kinase and its inhibitors].
Topics: Arthritis, Rheumatoid; Humans; Janus Kinase 3; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles | 2016 |
Adverse events, clinical considerations and management recommendations in rheumatoid arthritis patients treated with JAK inhibitors.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Azetidines; Clinical Trials as Topic; Humans; Janus Kinase 1; Piperidines; Purines; Pyrazoles; Pyrimidines; Pyrroles; Sulfonamides | 2018 |
The 6π-azaelectrocyclization of azatrienes. Synthetic applications in natural products, bioactive heterocycles, and related fields.
Topics: Alkaloids; Aza Compounds; Biological Products; Chemistry Techniques, Synthetic; Cyclization; Histamine Agonists; Piperidines; Pyridines; Pyrroles; Quinazolines; Quinolizines; Sesquiterpenes | 2019 |
Role of janus kinase inhibitors in the treatment of alopecia areata.
Topics: Alopecia Areata; Animals; Humans; Janus Kinase Inhibitors; Janus Kinases; Piperidines; Pyrimidines; Pyrroles | 2018 |
Tofacitinib for the treatment of psoriasis and psoriatic arthritis.
Topics: Antirheumatic Agents; Arthritis, Psoriatic; Clinical Trials as Topic; Drug Approval; Humans; Janus Kinases; Nasopharyngitis; Piperidines; Protein Kinase Inhibitors; Psoriasis; Pyrimidines; Pyrroles | 2018 |
An Excellent Response to Tofacitinib in a Pediatric Alopecia Patient: A Case Report and Review.
Topics: Alopecia Areata; Child; Drug Therapy, Combination; Follow-Up Studies; Humans; Male; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Steroids; Treatment Outcome | 2018 |
Comparison of the efficacy and safety of tofacitinib and baricitinib in patients with active rheumatoid arthritis: a Bayesian network meta-analysis of randomized controlled trials.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Azetidines; Bayes Theorem; Humans; Network Meta-Analysis; Piperidines; Purines; Pyrazoles; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Sulfonamides | 2019 |
Oral small molecules for psoriasis.
Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Humans; Patient Selection; Piperidines; Protein Kinase Inhibitors; Psoriasis; Pyrimidines; Pyrroles; Thalidomide; Thiazoles | 2018 |
Targeted therapies for psoriatic arthritis: an update for the dermatologist.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Psoriatic; Dermatologic Agents; Dermatology; Humans; Interleukin-17; Interleukin-23; Janus Kinase Inhibitors; Molecular Targeted Therapy; Phosphodiesterase 4 Inhibitors; Piperidines; Pyrimidines; Pyrroles; Severity of Illness Index; Thalidomide; Tumor Necrosis Factor-alpha | 2018 |
Adverse drug events associated with 5mg versus 10mg Tofacitinib (Janus kinase inhibitor) twice daily for the treatment of autoimmune diseases: A systematic review and meta-analysis of randomized controlled trials.
Topics: Autoimmune Diseases; Dose-Response Relationship, Drug; Humans; Janus Kinase Inhibitors; Piperidines; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Treatment Outcome | 2019 |
Tofacitinib for the treatment of ulcerative colitis.
Topics: Animals; Colitis, Ulcerative; Drug-Related Side Effects and Adverse Reactions; Expert Testimony; Humans; Janus Kinases; Piperidines; Pyrimidines; Pyrroles; Quality of Life; Signal Transduction; STAT Transcription Factors; Treatment Outcome | 2018 |
Emerging Therapies for Inflammatory Bowel Disease.
Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized; Female; Gastrointestinal Agents; Humans; Inflammatory Bowel Diseases; Male; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles | 2018 |
Systematic review with network meta-analysis: the impact of medical interventions for moderate-to-severe ulcerative colitis on health-related quality of life.
Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Biological Products; Colitis, Ulcerative; Gastrointestinal Agents; Humans; Infliximab; Network Meta-Analysis; Piperidines; Pyrimidines; Pyrroles; Quality of Life; Severity of Illness Index | 2018 |
Therapies in ankylosing spondylitis-from clinical trials to clinical practice.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Health Services Needs and Demand; Humans; Piperidines; Pyrimidines; Pyrroles; Spondylitis, Ankylosing; Translational Research, Biomedical; Ustekinumab | 2018 |
The Emperor's New Gepants: Are the Effects of the New Oral CGRP Antagonists Clinically Meaningful?
Topics: Calcitonin Gene-Related Peptide Receptor Antagonists; Humans; Migraine Disorders; Piperidines; Pyridines; Pyrroles | 2019 |
Advances in orally administered pharmacotherapy for the treatment of migraine.
Topics: Administration, Oral; Humans; Migraine Disorders; Piperidines; Pyridines; Pyrroles; Tryptamines | 2019 |
Clinical significance of Janus Kinase inhibitor selectivity.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Azetidines; Humans; Inflammation; Janus Kinase Inhibitors; Piperidines; Purines; Pyrazoles; Pyrimidines; Pyrroles; Sulfonamides | 2019 |
JAK-STAT inhibitors for the treatment of immunomediated diseases.
Topics: Autoimmune Diseases; Azetidines; Humans; Immunologic Factors; Inflammatory Bowel Diseases; Janus Kinase Inhibitors; Piperidines; Purines; Pyrazoles; Pyrimidines; Pyrroles; STAT Transcription Factors; Sulfonamides | 2019 |
A Bayesian mixed treatment comparison of efficacy of biologics and small molecules in early rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Bayes Theorem; Biological Factors; Drug Therapy, Combination; Etanercept; Humans; Infliximab; Methotrexate; Network Meta-Analysis; Piperidines; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Rituximab; Treatment Outcome | 2019 |
Tuberculosis, hepatitis B and herpes zoster in tofacitinib-treated patients with rheumatoid arthritis.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Asia, Eastern; Drug Therapy, Combination; Herpes Zoster; Herpesvirus 3, Human; Humans; Mycobacterium tuberculosis; Piperidines; Prevalence; Pyrimidines; Pyrroles; Recurrence; Risk; Tuberculosis; Virus Activation | 2019 |
Managing Risks with Biologics.
Topics: Antibodies, Monoclonal, Humanized; Biological Products; Demyelinating Diseases; Deprescriptions; Drug Substitution; Gastrointestinal Agents; Humans; Infections; Inflammatory Bowel Diseases; Lymphoma; Melanoma; Neoplasms; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Risk; Risk Assessment; Skin Neoplasms; Tumor Necrosis Factor-alpha; Ustekinumab | 2019 |
Time until onset of action when treating psoriatic arthritis: meta-analysis and novel approach of generating confidence intervals.
Topics: Adalimumab; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Psoriatic; Confidence Intervals; Humans; Infliximab; Methotrexate; Piperidines; Pyrimidines; Pyrroles; Thalidomide; Time Factors; Treatment Outcome; Tumor Necrosis Factor Inhibitors; Ustekinumab | 2019 |
Network meta-analysis of tofacitinib versus biologic treatments in moderate-to-severe rheumatoid arthritis patients.
Topics: Arthritis, Rheumatoid; Biological Products; Humans; Network Meta-Analysis; Piperidines; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic | 2019 |
Joint AAD-NPF guidelines of care for the management and treatment of psoriasis with biologics.
Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Biological Products; Biosimilar Pharmaceuticals; Certolizumab Pegol; Dermatologic Agents; Drug Therapy, Combination; Etanercept; Evidence-Based Medicine; Humans; Infliximab; Piperidines; Psoriasis; Pyrimidines; Pyrroles; Ustekinumab | 2019 |
Clinical efficacy of new JAK inhibitors under development. Just more of the same?
Topics: Adamantane; Arthritis, Rheumatoid; Azetidines; Heterocyclic Compounds, 2-Ring; Heterocyclic Compounds, 3-Ring; Humans; Janus Kinase 1; Janus Kinase 3; Janus Kinase Inhibitors; Niacinamide; Piperidines; Purines; Pyrazoles; Pyridines; Pyrimidines; Pyrroles; Sulfonamides; Treatment Outcome; Triazoles; Valine | 2019 |
Clinical efficacy of launched JAK inhibitors in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Azetidines; Drug Therapy, Combination; Humans; Janus Kinase 1; Janus Kinase 2; Janus Kinase 3; Janus Kinase Inhibitors; Methotrexate; Piperidines; Purines; Pyrazoles; Pyrimidines; Pyrroles; Sulfonamides; Treatment Outcome | 2019 |
Comparison of the Efficacy and Safety of Tofacitinib and Apremilast in Patients with Active Psoriatic Arthritis: A Bayesian Network Meta-Analysis of Randomized Controlled Trials.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Psoriatic; Bayes Theorem; Humans; Network Meta-Analysis; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Thalidomide; Treatment Outcome | 2019 |
What's New in Hair Loss.
Topics: 5-alpha Reductase Inhibitors; Alopecia; Alopecia Areata; Azetidines; Humans; Janus Kinase Inhibitors; Nitriles; Piperidines; Platelet-Rich Plasma; Purines; Pyrazoles; Pyrimidines; Pyrroles; Retinoids; Sulfonamides | 2019 |
Tofacitinib: A Review in Psoriatic Arthritis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Psoriatic; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Methotrexate; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Treatment Outcome; Young Adult | 2019 |
A systematic review and meta-analysis of infection risk with small molecule JAK inhibitors in rheumatoid arthritis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Azetidines; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Female; Herpes Zoster; Heterocyclic Compounds, 3-Ring; Humans; Incidence; Infections; Janus Kinase Inhibitors; Male; Middle Aged; Piperidines; Purines; Pyrazoles; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Sulfonamides | 2019 |
Tofacitinib for the treatment of rheumatoid arthritis: an update.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Piperidines; Pyrimidines; Pyrroles | 2019 |
JAK3-selective inhibitor peficitinib for the treatment of rheumatoid arthritis.
Topics: Adamantane; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Cell Proliferation; Humans; Janus Kinase 3; Janus Kinase Inhibitors; Methotrexate; Niacinamide; Piperidines; Pyrimidines; Pyrroles | 2019 |
The Era of Anti-Tumor Necrosis Factor Is Over. What Do We Know, What Don't We Know, and What Do We Yearn to Know?
Topics: Adalimumab; Antibodies, Monoclonal; Biosimilar Pharmaceuticals; Drug Therapy, Combination; Gastrointestinal Agents; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Infliximab; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Severity of Illness Index; Tumor Necrosis Factor-alpha | 2019 |
The use of Tofacitinib in the treatment of inflammatory bowel disease.
Topics: Humans; Inflammatory Bowel Diseases; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Signal Transduction; STAT Transcription Factors | 2019 |
Efficacy and safety of tofacitinib for the treatment of chronic plaque psoriasis: a systematic review and meta-analysis.
Topics: Chronic Disease; Humans; Piperidines; Protein Kinase Inhibitors; Psoriasis; Pyrimidines; Pyrroles; Treatment Outcome | 2019 |
Changes in Lipid Levels and Incidence of Cardiovascular Events Following Tofacitinib Treatment in Patients With Psoriatic Arthritis: A Pooled Analysis Across Phase III and Long-Term Extension Studies.
Topics: Arthritis, Psoriatic; Cardiovascular Diseases; Clinical Trials, Phase III as Topic; Humans; Incidence; Lipids; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Treatment Outcome | 2019 |
Drugs targeting the JAK/STAT pathway for the treatment of immune-mediated inflammatory skin diseases: protocol for a scoping review.
Topics: Humans; Janus Kinase Inhibitors; Janus Kinases; Nitriles; Piperidines; Pyrazoles; Pyrimidines; Pyrroles; Skin Diseases; STAT Transcription Factors | 2019 |
[JAK Inhibitors in Rheumatology].
Topics: Arthritis, Rheumatoid; Azetidines; Germany; Humans; Janus Kinase Inhibitors; Piperidines; Purines; Pyrazoles; Pyrimidines; Pyrroles; Sulfonamides | 2019 |
Comparison of the efficacy and safety of tofacitinib and upadacitinib in patients with active rheumatoid arthritis: A Bayesian network meta-analysis of randomized controlled trials.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Bayes Theorem; Drug Therapy, Combination; Heterocyclic Compounds, 3-Ring; Humans; Janus Kinase Inhibitors; Methotrexate; Network Meta-Analysis; Piperidines; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Treatment Outcome | 2019 |
Janus kinase inhibitors: An innovative treatment for alopecia areata.
Topics: Administration, Oral; Alopecia Areata; Azetidines; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Janus Kinase Inhibitors; Janus Kinases; Middle Aged; Nitriles; Piperidines; Purines; Pyrazoles; Pyrimidines; Pyrroles; Signal Transduction; Sulfonamides; T-Lymphocytes, Cytotoxic; Treatment Outcome | 2019 |
Current Unmet Needs in Spondyloarthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Delayed Diagnosis; Humans; Interleukin-17; Interleukin-23; Janus Kinase Inhibitors; Magnetic Resonance Imaging; Molecular Targeted Therapy; Piperidines; Practice Guidelines as Topic; Pyrimidines; Pyrroles; Referral and Consultation; Spondylarthropathies; Tumor Necrosis Factor Inhibitors; Ustekinumab | 2019 |
Innovations in Oral Therapies for Inflammatory Bowel Disease.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Drug Discovery; Heterocyclic Compounds, 3-Ring; Humans; Indans; Inflammatory Bowel Diseases; Janus Kinase Inhibitors; Mesalamine; Oxadiazoles; Phosphodiesterase Inhibitors; Piperidines; Pyridines; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Receptors, Lysosphingolipid; Triazoles | 2019 |
Novel topical and systemic therapies in atopic dermatitis.
Topics: Acrylamides; Administration, Topical; Antibodies, Monoclonal, Humanized; Biological Products; Boron Compounds; Bridged Bicyclo Compounds, Heterocyclic; Dermatitis, Atopic; Humans; Immunotherapy; Interleukin-13; Janus Kinase Inhibitors; Molecular Targeted Therapy; Phosphodiesterase 4 Inhibitors; Piperidines; Pyridines; Pyrimidines; Pyrroles; Resorcinols; Stilbenes; TRPV Cation Channels | 2019 |
Stereoelectronic Effects in Ligand Design: Enantioselective Rhodium-Catalyzed Hydrogenation of Aliphatic Cyclic Tetrasubstituted Enamides and Concise Synthesis of (R)-Tofacitinib.
Topics: Catalysis; Hydrogenation; Ligands; Piperidines; Pyrimidines; Pyrroles; Rhodium; Stereoisomerism | 2019 |
Inhibitors of the Janus Kinases: A New Oral Treatment Option for Ulcerative Colitis.
Topics: Administration, Oral; Colitis, Ulcerative; Humans; Janus Kinase Inhibitors; Piperidines; Pyrimidines; Pyrroles; Quality of Life | 2019 |
An evaluation of tofacitinib for the treatment of psoriatic arthritis.
Topics: Arthritis, Psoriatic; Clinical Trials as Topic; Dose-Response Relationship, Drug; Half-Life; Humans; Janus Kinases; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles | 2019 |
[Role of janus kinase inhibitors in the treatment of rheumatic diseases].
Topics: Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Azetidines; Drug Therapy, Combination; Humans; Janus Kinase Inhibitors; Methotrexate; Piperidines; Purines; Pyrazoles; Pyrimidines; Pyrroles; Sulfonamides; Treatment Outcome | 2019 |
Maneuvering Clinical Pathways for Ulcerative Colitis.
Topics: Antibodies, Monoclonal, Humanized; Colitis, Ulcerative; Critical Pathways; Gastrointestinal Agents; Humans; Piperidines; Practice Guidelines as Topic; Prognosis; Pyrimidines; Pyrroles; Risk Assessment; Treatment Outcome | 2019 |
Benefit and risk profile of tofacitinib for the treatment of alopecia areata: a systemic review and meta-analysis.
Topics: Alopecia Areata; Humans; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Risk Assessment | 2020 |
In brief: Risk of pulmonary thromboembolism and death with tofacitinib.
Topics: Drug Labeling; Humans; Piperidines; Protein Kinase Inhibitors; Pulmonary Embolism; Pyrimidines; Pyrroles; Risk Factors; Treatment Outcome | 2019 |
Effect of biologics and targeted synthetic disease-modifying anti-rheumatic drugs on fatigue in rheumatoid arthritis.
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Azetidines; Biological Products; Fatigue; Humans; Piperidines; Purines; Pyrazoles; Pyrimidines; Pyrroles; Sulfonamides | 2019 |
Comparison of the efficacy and safety of tofacitinib and filgotinib in patients with active rheumatoid arthritis: a Bayesian network meta-analysis of randomized controlled trials.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Bayes Theorem; Drug Therapy, Combination; Humans; Methotrexate; Network Meta-Analysis; Piperidines; Pyridines; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Treatment Outcome; Triazoles | 2020 |
Profile of Tofacitinib in the Treatment of Ulcerative Colitis: An Evidence-Based Review of Recent Data.
Topics: Administration, Oral; Colitis, Ulcerative; Humans; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles | 2019 |
Efficacy and safety of biologic agents and tofacitinib in moderate-to-severe ulcerative colitis: A systematic overview of meta-analyses.
Topics: Biological Factors; Biomarkers; Clinical Trials as Topic; Colitis, Ulcerative; Drug Therapy, Combination; Humans; Molecular Targeted Therapy; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Severity of Illness Index; Treatment Outcome | 2019 |
Safety of Janus Kinase Inhibitors in Patients With Inflammatory Bowel Diseases or Other Immune-mediated Diseases: A Systematic Review and Meta-Analysis.
Topics: Arthritis, Rheumatoid; Azetidines; Herpes Zoster; Heterocyclic Compounds, 3-Ring; Humans; Incidence; Inflammatory Bowel Diseases; Janus Kinase Inhibitors; Janus Kinases; Piperidines; Placebos; Psoriasis; Purines; Pyrazoles; Pyridines; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Spondylitis, Ankylosing; Sulfonamides; Survival Analysis; Treatment Outcome; Triazoles | 2020 |
Osteoimmunology in rheumatoid and psoriatic arthritis: potential effects of tofacitinib on bone involvement.
Topics: Arthritis, Psoriatic; Arthritis, Rheumatoid; Bone and Bones; Bone Remodeling; Humans; Immune System; Janus Kinases; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Signal Transduction; STAT Transcription Factors | 2020 |
Oral Janus kinase inhibitors for maintenance of remission in ulcerative colitis.
Topics: Colitis, Ulcerative; Humans; Janus Kinase Inhibitors; Maintenance Chemotherapy; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Quality of Life; Randomized Controlled Trials as Topic | 2020 |
First-Line Biologics or Small Molecules in Inflammatory Bowel Disease: a Practical Guide for the Clinician.
Topics: Antibodies, Monoclonal, Humanized; Biological Products; Clinical Trials as Topic; Comparative Effectiveness Research; Humans; Inflammatory Bowel Diseases; Piperidines; Practice Guidelines as Topic; Protein Kinase Inhibitors; Pyrimidines; Pyrroles | 2020 |
Targeted synthetic pharmacotherapy for psoriatic arthritis: state of the art.
Topics: Administration, Oral; Antirheumatic Agents; Arthritis, Psoriatic; Azetidines; Humans; Janus Kinases; Molecular Targeted Therapy; Phosphodiesterase 4 Inhibitors; Piperidines; Purines; Pyrazoles; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Sulfonamides; Thalidomide; Treatment Outcome | 2020 |
Clinical Pharmacology of Janus Kinase Inhibitors in Inflammatory Bowel Disease.
Topics: Heterocyclic Compounds, 3-Ring; Humans; Inflammatory Bowel Diseases; Janus Kinase Inhibitors; Piperidines; Pyrazoles; Pyridines; Pyrimidines; Pyrroles; Triazoles | 2020 |
JAK inhibitors in chronic plaque psoriasis: What is known so far.
Topics: Adamantane; Azetidines; Humans; Janus Kinase Inhibitors; Janus Kinases; Niacinamide; Nitriles; Piperidines; Prospective Studies; Psoriasis; Purines; Pyrazoles; Pyridines; Pyrimidines; Pyrroles; Sulfonamides; Triazoles | 2020 |
Gepants, calcitonin-gene-related peptide receptor antagonists: what could be their role in migraine treatment?
Topics: Calcitonin Gene-Related Peptide Receptor Antagonists; Humans; Migraine Disorders; Piperidines; Pyridines; Pyrroles; Randomized Controlled Trials as Topic; Treatment Outcome | 2020 |
Comparative Efficacy of JAK Inhibitors for Moderate-To-Severe Rheumatoid Arthritis: A Network Meta-Analysis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Azetidines; Bayes Theorem; Clinical Trials, Phase III as Topic; Drug Therapy, Combination; Female; Heterocyclic Compounds, 3-Ring; Humans; Janus Kinase Inhibitors; Methotrexate; Network Meta-Analysis; Piperidines; Purines; Pyrazoles; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Severity of Illness Index; Sulfonamides | 2020 |
Comparative efficacy and safety of tofacitinib, baricitinib, upadacitinib, and filgotinib in active rheumatoid arthritis refractory to biologic disease-modifying antirheumatic drugs.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Azetidines; Biological Products; Heterocyclic Compounds, 3-Ring; Humans; Methotrexate; Piperidines; Purines; Pyrazoles; Pyridines; Pyrimidines; Pyrroles; Sulfonamides; Treatment Outcome; Triazoles | 2021 |
JAK inhibitors for the treatment of rheumatoid arthritis.
Topics: Adamantane; Antirheumatic Agents; Arthritis, Rheumatoid; Azetidines; Benzofurans; Cardiovascular Diseases; Herpes Zoster; Humans; Janus Kinases; Molecular Targeted Therapy; Neutropenia; Niacinamide; Piperidines; Protein Kinase Inhibitors; Purines; Pyrazoles; Pyrimidines; Pyrroles; Sulfonamides; Venous Thromboembolism | 2020 |
A case of new-onset vitiligo in a patient on tofacitinib and brief review of paradoxical presentations with other novel targeted therapies.
Topics: Adult; Arthritis, Rheumatoid; Female; Hidradenitis Suppurativa; Humans; Janus Kinase Inhibitors; Keratoacanthoma; Melanoma; Piperidines; Programmed Cell Death 1 Receptor; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Psoriasis; Pyrimidines; Pyrroles; Tumor Necrosis Factor-alpha; Vitiligo | 2020 |
Cost-Effectiveness of Tofacitinib for Patients with Moderate-to-Severe Rheumatoid Arthritis in China.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; China; Cost-Benefit Analysis; Humans; Methotrexate; Piperidines; Pyrimidines; Pyrroles; Quality-Adjusted Life Years; Treatment Outcome | 2020 |
Relative efficacy and safety of tofacitinib for treating psoriasis: A Bayesian network meta-analysis of randomized controlled trials.
Topics: Humans; Network Meta-Analysis; Piperidines; Psoriasis; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Treatment Outcome | 2021 |
Efficacy of Tofacitinib in the Treatment of Psoriatic Arthritis: A Systematic Review.
Topics: Antirheumatic Agents; Arthritis, Psoriatic; Humans; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Treatment Outcome | 2021 |
Biological Therapies for Atopic Dermatitis: A Systematic Review.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Azetidines; Biological Products; Carbamates; Clinical Trials as Topic; Dermatitis, Atopic; Dermatologic Agents; Heterocyclic Compounds, 3-Ring; Humans; Nitriles; Piperidines; Protein Kinase Inhibitors; Purines; Pyrazoles; Pyrimidines; Pyrroles; Sulfonamides | 2021 |
Comparison of the efficacy and safety of tofacitinib and mavrilimumab in patients with active rheumatoid arthritis: A Bayesian network meta-analysis of randomized controlled trials.
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Network Meta-Analysis; Piperidines; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Treatment Outcome | 2021 |
Comparative efficacy and safety of rimegepant, ubrogepant, and lasmiditan for acute treatment of migraine: a network meta-analysis.
Topics: Adult; Benzamides; Humans; Migraine Disorders; Network Meta-Analysis; Piperidines; Pyridines; Pyrroles; Randomized Controlled Trials as Topic; Treatment Outcome | 2022 |
Novel candidates in the clinical development pipeline for TB drug development and their synthetic approaches.
Topics: Adamantane; Animals; Antitubercular Agents; DNA Gyrase; Drug Development; Enzyme Inhibitors; Humans; Isonicotinic Acids; Mycobacterium tuberculosis; Oxazolidinones; Piperidines; Pyrroles; Structure-Activity Relationship; Tuberculosis; Tuberculosis, Multidrug-Resistant; Uridine | 2021 |
The Era of Janus Kinase Inhibitors for Inflammatory Bowel Disease Treatment.
Topics: Adamantane; Colitis; Colitis, Ulcerative; Crohn Disease; Heterocyclic Compounds, 3-Ring; Humans; Inflammatory Bowel Diseases; Janus Kinase Inhibitors; Janus Kinases; Niacinamide; Piperidines; Pyridines; Pyrimidines; Pyrroles; Triazoles | 2021 |
Atogepant: First Approval.
Topics: Calcitonin Gene-Related Peptide Receptor Antagonists; Drug Approval; Drug Interactions; Humans; Migraine Disorders; Piperidines; Pyridines; Pyrroles; Spiro Compounds; United States; United States Food and Drug Administration | 2022 |
The efficacy and safety of atogepant for the prophylactic treatment of migraine: evidence from randomized controlled trials.
Topics: Analgesics; Humans; Migraine Disorders; Piperidines; Pyridines; Pyrroles; Randomized Controlled Trials as Topic; Spiro Compounds; Treatment Outcome | 2022 |
Atogepant for Migraine Prevention: A Systematic Review of Efficacy and Safety.
Topics: Analgesics; Calcitonin Gene-Related Peptide; Double-Blind Method; Headache; Humans; Migraine Disorders; Multicenter Studies as Topic; Piperidines; Pyridines; Pyrroles; Randomized Controlled Trials as Topic; Spiro Compounds; Treatment Outcome | 2022 |
Tofacitinib in paediatric dermatoses: a narrative review.
Topics: Alopecia Areata; Child; Humans; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles | 2022 |
Prognostic indicators of disease progression in Duchenne muscular dystrophy: A literature review and evidence synthesis.
Topics: Disease Progression; Glucocorticoids; Humans; Morpholines; Muscular Dystrophy, Duchenne; Piperidines; Prognosis; Pyrroles | 2022 |
Small molecule CGRP receptor antagonists for the preventive treatment of migraine: A review.
Topics: Adult; Analgesics; Calcitonin Gene-Related Peptide Receptor Antagonists; Humans; Migraine Disorders; Piperidines; Pyridines; Pyrroles; Quality of Life; Spiro Compounds | 2022 |
Real-world evidence of tofacitinib in rheumatoid arthritis patients in Spain.
Topics: Arthritis, Rheumatoid; Female; Humans; Male; Middle Aged; Piperidines; Pyrimidines; Pyrroles; Retrospective Studies; Spain; Treatment Outcome | 2022 |
Gepants - a long way to cure: a narrative review.
Topics: Antibodies, Monoclonal; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Humans; Migraine Disorders; Piperidines; Pyridines; Pyrroles; Randomized Controlled Trials as Topic; Spiro Compounds | 2022 |
Relative efficacy of lasmiditan versus rimegepant and ubrogepant as acute treatments for migraine: network meta-analysis findings.
Topics: Adult; Benzamides; Double-Blind Method; Female; Humans; Middle Aged; Migraine Disorders; Network Meta-Analysis; Piperidines; Pyridines; Pyrroles; Randomized Controlled Trials as Topic | 2022 |
Positioning of tofacitinib in treatment of ulcerative colitis: a global perspective.
Topics: Aged; Biosimilar Pharmaceuticals; Colitis, Ulcerative; Humans; Piperidines; Pyrimidines; Pyrroles | 2022 |
Review article: guide to tofacitinib dosing in patients with ulcerative colitis.
Topics: Colitis, Ulcerative; Humans; Piperidines; Pyrimidines; Pyrroles; Recurrence | 2022 |
Rimegepant, Ubrogepant, and Lasmiditan in the Acute Treatment of Migraine Examining the Benefit-Risk Profile Using Number Needed to Treat/Harm.
Topics: Adult; Bayes Theorem; Benzamides; Dizziness; Double-Blind Method; Humans; Migraine Disorders; Nausea; Piperidines; Pyridines; Pyrroles; Serotonin Receptor Agonists; Treatment Outcome | 2022 |
Efficacy and safety of tofacitinib for treatment of alopecia areata in children: A systematic review and meta-analysis.
Topics: Alopecia Areata; Child; Humans; Piperidines; Pyrroles | 2022 |
Ubrogepant and rimegepant: systematic review, meta-analysis, and meta-regression of clinical studies.
Topics: Drug-Related Side Effects and Adverse Reactions; Humans; Piperidines; Pyridines; Pyrroles | 2023 |
178 trial(s) available for pyrroles and piperidines
| Article | Year |
|---|---|
Pharmacokinetics, metabolism and bioavailability of the new anti-allergic drug BM 113. Part III: Pharmacokinetics, metabolism, dose dependency and gender effect after single or repeated administration to human healthy volunteers.
Topics: Adult; Anti-Allergic Agents; Area Under Curve; Biological Availability; Biotransformation; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Female; Humans; Male; Piperazines; Piperidines; Pyrroles; Sex Characteristics | 1999 |
Phase 1 dose-escalation study of CP-690 550 in stable renal allograft recipients: preliminary findings of safety, tolerability, effects on lymphocyte subsets and pharmacokinetics.
Topics: Adolescent; Adult; Aged; Double-Blind Method; Female; Graft Survival; Humans; Janus Kinase 3; Kidney Transplantation; Lymphocytes; Male; Middle Aged; Mycophenolic Acid; Piperidines; Pyrimidines; Pyrroles; Transplantation, Homologous | 2008 |
The Atorvastatin/Donepezil in Alzheimer's Disease Study (LEADe): design and baseline characteristics.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Anticholesteremic Agents; Atorvastatin; Cholinesterase Inhibitors; Donepezil; Drug Therapy, Combination; Female; Heptanoic Acids; Humans; Indans; Lipids; Male; Middle Aged; Piperidines; Pyrroles | 2008 |
The effect of the JAK inhibitor CP-690,550 on peripheral immune parameters in stable kidney allograft patients.
Topics: Cell Proliferation; Cells, Cultured; Female; Gene Expression Regulation; Health; Humans; Immune System; Interferon-gamma; Interleukin-2; Interleukin-2 Receptor alpha Subunit; Janus Kinase 3; Kidney Transplantation; Male; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; T-Lymphocytes; Transplantation, Homologous | 2009 |
Double-blind, placebo-controlled, dose-escalation study to evaluate the pharmacologic effect of CP-690,550 in patients with psoriasis.
Topics: Adult; Biopsy; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Middle Aged; Piperidines; Psoriasis; Pyrimidines; Pyrroles | 2009 |
Effects of gemfibrozil and atorvastatin on the pharmacokinetics of repaglinide in relation to SLCO1B1 polymorphism.
Topics: Administration, Oral; Adult; Area Under Curve; Atorvastatin; Blood Glucose; Carbamates; Cross-Over Studies; Drug Interactions; Female; Gemfibrozil; Genotype; Half-Life; Heptanoic Acids; Humans; Hypoglycemic Agents; Hypolipidemic Agents; Liver-Specific Organic Anion Transporter 1; Male; Organic Anion Transporters; Piperidines; Polymorphism, Genetic; Pyrroles | 2008 |
Effect of CP-690,550, an orally active janus kinase inhibitor, on renal function in healthy adult volunteers.
Topics: Administration, Oral; Adult; Double-Blind Method; Glomerular Filtration Rate; Humans; Immunosuppressive Agents; Iohexol; Janus Kinase 3; Kidney; Kidney Function Tests; Male; Middle Aged; p-Aminohippuric Acid; Piperidines; Placebos; Pyrimidines; Pyrroles; Renal Plasma Flow, Effective | 2009 |
The safety and efficacy of a JAK inhibitor in patients with active rheumatoid arthritis: Results of a double-blind, placebo-controlled phase IIa trial of three dosage levels of CP-690,550 versus placebo.
Topics: Arthritis, Rheumatoid; Cholesterol, HDL; Cholesterol, LDL; Creatinine; Dose-Response Relationship, Drug; Double-Blind Method; Female; Headache; Humans; International Cooperation; Janus Kinases; Male; Middle Aged; Nausea; Piperidines; Pyrimidines; Pyrroles; Treatment Outcome | 2009 |
Improved pain, physical functioning and health status in patients with rheumatoid arthritis treated with CP-690,550, an orally active Janus kinase (JAK) inhibitor: results from a randomised, double-blind, placebo-controlled trial.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Epidemiologic Methods; Female; Humans; Janus Kinase 3; Male; Middle Aged; Pain; Pain Measurement; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Recovery of Function; Treatment Outcome | 2010 |
Calcineurin-inhibitor-free immunosuppression based on the JAK inhibitor CP-690,550: a pilot study in de novo kidney allograft recipients.
Topics: Adrenal Cortex Hormones; Adult; Aged; Biopsy; Calcineurin Inhibitors; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Follow-Up Studies; Glomerular Filtration Rate; Graft Rejection; Humans; Immunosuppressive Agents; Janus Kinases; Kaplan-Meier Estimate; Kidney; Kidney Transplantation; Male; Middle Aged; Mycophenolic Acid; Pilot Projects; Piperidines; Pyrimidines; Pyrroles; Tacrolimus; Transplantation, Homologous; Young Adult | 2009 |
Monitoring of the immunomodulatory effect of CP-690,550 by analysis of the JAK/STAT pathway in kidney transplant patients.
Topics: Animals; Blotting, Western; Cell Division; Dose-Response Relationship, Drug; Flow Cytometry; Humans; Immunosuppressive Agents; Janus Kinase 3; Kidney Transplantation; Killer Cells, Natural; Monitoring, Physiologic; Mycophenolic Acid; Piperidines; Placebos; Prednisolone; Primates; Pyrimidines; Pyrroles; Rodentia; Safety; STAT5 Transcription Factor; T-Lymphocytes | 2009 |
A semi-mechanistic model of CP-690,550-induced reduction in neutrophil counts in patients with rheumatoid arthritis.
Topics: Adolescent; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Models, Biological; Neutropenia; Piperidines; Pyrimidines; Pyrroles; Time Factors | 2010 |
Co-administration of the JAK inhibitor CP-690,550 and methotrexate is well tolerated in patients with rheumatoid arthritis without need for dose adjustment.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Female; Humans; Janus Kinase 3; Male; Methotrexate; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Treatment Outcome | 2010 |
The Jak inhibitor CP-690,550 preserves the function of CD4CD25FoxP3 regulatory T cells and inhibits effector T cells.
Topics: CD4-Positive T-Lymphocytes; Female; Humans; Interleukin-2; Interleukin-2 Receptor alpha Subunit; Kidney Transplantation; Male; Middle Aged; Piperidines; Pyrimidines; Pyrroles; STAT5 Transcription Factor; T-Lymphocytes; T-Lymphocytes, Regulatory | 2010 |
Metabolism and disposition of [14C]BMS-690514, an ErbB/vascular endothelial growth factor receptor inhibitor, after oral administration to humans.
Topics: Absorption; Administration, Oral; Adolescent; Adult; Antineoplastic Agents; Bile; Biotransformation; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cytochrome P-450 CYP2D6; Dose-Response Relationship, Drug; Feces; Glucuronides; Glucuronosyltransferase; Humans; Hydroxylation; Male; Oxidation-Reduction; Piperidines; Polymorphism, Single Nucleotide; Protein Kinases; Pyrroles; Receptor Protein-Tyrosine Kinases; Tissue Distribution; Triazines; Young Adult | 2010 |
Population pharmacokinetic analysis of mycophenolic acid coadministered with either tasocitinib (CP-690,550) or tacrolimus in adult renal allograft recipients.
Topics: Adult; Area Under Curve; Dose-Response Relationship, Drug; Drug Therapy, Combination; Graft Rejection; Humans; Immunosuppressive Agents; Kidney Transplantation; Models, Biological; Mycophenolic Acid; Piperidines; Pyrimidines; Pyrroles; Tacrolimus | 2010 |
A supratherapeutic dose of the Janus kinase inhibitor tasocitinib (CP-690,550) does not prolong QTc interval in healthy participants.
Topics: Adult; Cross-Over Studies; Double-Blind Method; Female; Follow-Up Studies; Heart Rate; Humans; Janus Kinase 3; Long QT Syndrome; Male; Middle Aged; Piperidines; Pyrimidines; Pyrroles; Systole; Young Adult | 2011 |
A phase I trial of MK-0731, a kinesin spindle protein (KSP) inhibitor, in patients with solid tumors.
Topics: Adult; Aged; Antineoplastic Agents; Area Under Curve; Female; Humans; Infusions, Intravenous; Kinesins; Leukocyte Count; Male; Middle Aged; Neoplasms; Piperidines; Pyrroles; Young Adult | 2012 |
Phase II study of tofacitinib (CP-690,550) combined with methotrexate in patients with rheumatoid arthritis and an inadequate response to methotrexate.
Topics: Adult; Antibodies, Monoclonal; Antirheumatic Agents; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Immunomodulation; Janus Kinase 3; Longitudinal Studies; Male; Methotrexate; Middle Aged; Piperidines; Pyrimidines; Pyrroles; Treatment Outcome | 2011 |
Phase IIb dose-ranging study of the oral JAK inhibitor tofacitinib (CP-690,550) or adalimumab monotherapy versus placebo in patients with active rheumatoid arthritis with an inadequate response to disease-modifying antirheumatic drugs.
Topics: Adalimumab; Administration, Oral; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Double-Blind Method; Drug Substitution; Drug Tolerance; Female; Health Status; Humans; Injections, Subcutaneous; Janus Kinase 3; Joints; Male; Methotrexate; Middle Aged; Pilot Projects; Piperidines; Pyrimidines; Pyrroles; Recovery of Function | 2012 |
A phase IIb dose-ranging study of the oral JAK inhibitor tofacitinib (CP-690,550) versus placebo in combination with background methotrexate in patients with active rheumatoid arthritis and an inadequate response to methotrexate alone.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Piperidines; Pyrimidines; Pyrroles; Treatment Outcome | 2012 |
Food increased the bioavailability of BMS-690514, an orally active EGFR/HER2/VEGF receptor kinase inhibitor, in healthy subjects.
Topics: Adult; Biological Availability; Cross-Over Studies; ErbB Receptors; Female; Food; Food-Drug Interactions; Humans; Male; Middle Aged; Piperidines; Pyrroles; Receptor, ErbB-2; Triazines; Vascular Endothelial Growth Factor A | 2012 |
Lack of effect of tofacitinib (CP-690,550) on the pharmacokinetics of the CYP3A4 substrate midazolam in healthy volunteers: confirmation of in vitro data.
Topics: Adult; Cross-Over Studies; Cytochrome P-450 CYP3A; Drug Interactions; Female; GABA Modulators; Half-Life; Humans; Janus Kinases; Male; Metabolic Clearance Rate; Midazolam; Middle Aged; Piperidines; Pyrimidines; Pyrroles; Young Adult | 2012 |
In vitro and in vivo analysis of a JAK inhibitor in rheumatoid arthritis.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; CD4-Positive T-Lymphocytes; Cells, Cultured; Cytokines; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Isoenzymes; Janus Kinase 3; Mice; Mice, SCID; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Signal Transduction | 2012 |
Tofacitinib (CP-690,550), a Janus kinase inhibitor for dry eye disease: results from a phase 1/2 trial.
Topics: Cyclosporine; Double-Blind Method; Dry Eye Syndromes; Female; Humans; Janus Kinase 3; Male; Middle Aged; Ophthalmic Solutions; Piperidines; Prospective Studies; Pyrimidines; Pyrroles; Surveys and Questionnaires; Tears; Treatment Outcome | 2012 |
Immunomodulatory effect of the topical ophthalmic Janus kinase inhibitor tofacitinib (CP-690,550) in patients with dry eye disease.
Topics: Administration, Topical; Conjunctiva; Cyclosporine; Cytokines; Dry Eye Syndromes; Female; Flow Cytometry; HLA-DR1 Antigen; Humans; Janus Kinase 3; Male; Middle Aged; Ophthalmic Solutions; Piperidines; Pyrimidines; Pyrroles; Tears | 2012 |
Randomized phase 2b trial of tofacitinib (CP-690,550) in de novo kidney transplant patients: efficacy, renal function and safety at 1 year.
Topics: Adult; Female; Humans; Immunosuppressive Agents; Janus Kinase 3; Kidney Transplantation; Male; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles | 2012 |
Placebo-controlled trial of tofacitinib monotherapy in rheumatoid arthritis.
Topics: Activities of Daily Living; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Disability Evaluation; Double-Blind Method; Enzyme Inhibitors; Female; Humans; Janus Kinase 3; Least-Squares Analysis; Leukocyte Count; Male; Middle Aged; Neutrophils; Piperidines; Pyrimidines; Pyrroles; Severity of Illness Index; Treatment Outcome | 2012 |
Tofacitinib or adalimumab versus placebo in rheumatoid arthritis.
Topics: Adalimumab; Adult; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Cholesterol; Double-Blind Method; Drug Therapy, Combination; Enzyme Inhibitors; Female; Humans; Janus Kinase 3; Least-Squares Analysis; Leukocyte Count; Lipoproteins; Male; Methotrexate; Middle Aged; Neutrophils; Piperidines; Pyrimidines; Pyrroles; Treatment Outcome | 2012 |
A phase I study of BMS-690514 in Japanese patients with advanced or metastatic solid tumors.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents; Female; Fluorodeoxyglucose F18; Humans; Male; Middle Aged; Neoplasm Metastasis; Neoplasms; Piperidines; Positron-Emission Tomography; Pyrroles; Triazines | 2012 |
Tofacitinib, an oral Janus kinase inhibitor, in active ulcerative colitis.
Topics: Administration, Oral; Adult; Colitis, Ulcerative; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Janus Kinases; Lipoproteins, HDL; Lipoproteins, LDL; Male; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Remission Induction | 2012 |
Efficacy and safety of tofacitinib, an oral Janus kinase inhibitor, in the treatment of psoriasis: a Phase 2b randomized placebo-controlled dose-ranging study.
Topics: Administration, Oral; Adult; Chronic Disease; Dermatologic Agents; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Janus Kinase 3; Male; Piperidines; Psoriasis; Pyrimidines; Pyrroles; Treatment Outcome | 2012 |
Pharmacodynamic analysis of tofacitinib and basiliximab in kidney allograft recipients.
Topics: Antibodies, Monoclonal; Basiliximab; Cyclosporine; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Interleukin-15; Interleukin-2; Interleukin-7; Janus Kinases; Kidney Transplantation; Lymphocyte Activation; Lymphocyte Count; Lymphocytes; Netherlands; Phosphorylation; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Receptors, Interleukin-2; Recombinant Fusion Proteins; Signal Transduction; STAT5 Transcription Factor; Tacrolimus; Time Factors; Treatment Outcome | 2012 |
Evaluation of drug interactions of GSK1292263 (a GPR119 agonist) with statins: from in vitro data to clinical study design.
Topics: Adolescent; Adult; Aged; Animals; Atorvastatin; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Demography; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Female; Fluorobenzenes; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Madin Darby Canine Kidney Cells; Male; Mesylates; Middle Aged; Oxadiazoles; Piperidines; Pyrimidines; Pyrroles; Reference Standards; Rosuvastatin Calcium; Simvastatin; Sulfonamides; Troleandomycin; Young Adult | 2013 |
Tofacitinib (CP-690,550), an oral Janus kinase inhibitor, improves patient-reported outcomes in a phase 2b, randomized, double-blind, placebo-controlled study in patients with moderate-to-severe psoriasis.
Topics: Adult; Double-Blind Method; Female; Humans; Janus Kinase 3; Male; Middle Aged; Patient Outcome Assessment; Patient Satisfaction; Piperidines; Protein Kinase Inhibitors; Psoriasis; Pyrimidines; Pyrroles; Quality of Life; Severity of Illness Index; Surveys and Questionnaires | 2014 |
Tofacitinib (CP-690,550) in combination with methotrexate in patients with active rheumatoid arthritis with an inadequate response to tumour necrosis factor inhibitors: a randomised phase 3 trial.
Topics: Adult; Aged; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Janus Kinases; Male; Maximum Tolerated Dose; Methotrexate; Middle Aged; Pain Measurement; Piperidines; Pyrimidines; Pyrroles; Recurrence; Risk Assessment; Severity of Illness Index; Time Factors; Treatment Failure; Treatment Outcome; Tumor Necrosis Factor-alpha | 2013 |
Tofacitinib (CP-690,550) in patients with rheumatoid arthritis receiving methotrexate: twelve-month data from a twenty-four-month phase III randomized radiographic study.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Drug Resistance; Female; Humans; Janus Kinase 3; Male; Methotrexate; Middle Aged; Motor Activity; Piperidines; Pyrimidines; Pyrroles; Radiography; Treatment Outcome | 2013 |
A randomized phase 2a efficacy and safety trial of the topical Janus kinase inhibitor tofacitinib in the treatment of chronic plaque psoriasis.
Topics: Administration, Cutaneous; Adult; Aged; Chronic Disease; Dermatologic Agents; Double-Blind Method; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Ointments; Piperidines; Protein Kinase Inhibitors; Psoriasis; Pyrimidines; Pyrroles; Treatment Outcome; Young Adult | 2013 |
A phase I trial to determine the safety, pharmacokinetics, and pharmacodynamics of intercalated BMS-690514 with paclitaxel/carboplatin (PC) in advanced or metastatic solid malignancies.
Topics: Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Carboplatin; Dose-Response Relationship, Drug; Female; Humans; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Metastasis; Neoplasms; Paclitaxel; Piperidines; Pyrroles; Treatment Outcome; Triazines | 2013 |
Psychometric validation of the physician global assessment scale for assessing severity of psoriasis disease activity.
Topics: Double-Blind Method; Factor Analysis, Statistical; Humans; Pain Measurement; Physicians; Piperidines; Protein Kinase Inhibitors; Psoriasis; Psychometrics; Pyrimidines; Pyrroles; Quality of Life; Reproducibility of Results; Severity of Illness Index | 2013 |
Open-label tofacitinib and double-blind atorvastatin in rheumatoid arthritis patients: a randomised study.
Topics: Administration, Oral; Adult; Arthritis, Rheumatoid; Atorvastatin; Cardiovascular Diseases; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipids; Male; Middle Aged; Piperidines; Placebos; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Treatment Outcome | 2014 |
Phase I-IIa study of BMS-690514, an EGFR, HER-2 and -4 and VEGFR-1 to -3 oral tyrosine kinase inhibitor, in patients with advanced or metastatic solid tumours.
Topics: Administration, Oral; Adult; Aged; Area Under Curve; Carcinoma, Non-Small-Cell Lung; Diarrhea; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; ErbB Receptors; Erlotinib Hydrochloride; Exanthema; Female; Humans; Lung Neoplasms; Male; Metabolic Clearance Rate; Middle Aged; Neoplasm Metastasis; Neoplasms; Piperidines; Protein Kinase Inhibitors; Pyrroles; Quinazolines; Receptor, ErbB-2; Treatment Outcome; Triazines; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-3 | 2013 |
Effect of tofacitinib, a Janus kinase inhibitor, on haematological parameters during 12 weeks of psoriasis treatment.
Topics: Adolescent; Adult; Aged; Basophils; Blood Cell Count; Chronic Disease; Dermatologic Agents; Dose-Response Relationship, Drug; Female; Hematocrit; Hemoglobins; Humans; Killer Cells, Natural; Leukocytes; Male; Middle Aged; Monocytes; Piperidines; Protein Kinase Inhibitors; Psoriasis; Pyrimidines; Pyrroles; Young Adult | 2013 |
Tofacitinib prevents radiographic progression in rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Disease Progression; Female; Humans; Male; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Radiography; Severity of Illness Index; Treatment Outcome | 2013 |
Tofacitinib in combination with nonbiologic disease-modifying antirheumatic drugs in patients with active rheumatoid arthritis: a randomized trial.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Janus Kinase 3; Male; Methotrexate; Middle Aged; Piperidines; Pyrimidines; Pyrroles; Remission Induction; Treatment Outcome | 2013 |
Preclinical to clinical translation of tofacitinib, a Janus kinase inhibitor, in rheumatoid arthritis.
Topics: Animals; Arthritis, Experimental; Double-Blind Method; Drug Evaluation, Preclinical; Humans; Janus Kinase 1; Janus Kinase 3; Male; Mice; Mice, Inbred DBA; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles | 2014 |
The relationship between pruritus and the clinical signs of psoriasis in patients receiving tofacitinib.
Topics: Adult; Double-Blind Method; Female; Humans; Male; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pruritus; Psoriasis; Psychometrics; Pyrimidines; Pyrroles; Reproducibility of Results; Treatment Outcome | 2015 |
Effects of tofacitinib on lymphocytes in rheumatoid arthritis: relation to efficacy and infectious adverse events.
Topics: Adult; Aged; Arthritis, Rheumatoid; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Count; Cell Proliferation; Double-Blind Method; Female; Humans; In Vitro Techniques; Infections; Male; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Risk Factors; Severity of Illness Index; Treatment Outcome | 2014 |
A phase 2 study of tofacitinib, an oral Janus kinase inhibitor, in patients with Crohn's disease.
Topics: Adult; Animals; Blood Chemical Analysis; C-Reactive Protein; Crohn Disease; Feces; Female; Humans; Janus Kinases; Leukocyte L1 Antigen Complex; Male; Middle Aged; Piperidines; Placebos; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Treatment Outcome | 2014 |
Efficacy of tofacitinib, an oral janus kinase inhibitor, on clinical signs of moderate-to-severe plaque psoriasis in different body regions.
Topics: Administration, Oral; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Janus Kinases; Piperidines; Protein Kinase Inhibitors; Psoriasis; Pyrimidines; Pyrroles; Severity of Illness Index; Treatment Outcome | 2014 |
Effects of Janus kinase inhibitor tofacitinib on circulating serum amyloid A and interleukin-6 during treatment for rheumatoid arthritis.
Topics: Adult; Anti-Inflammatory Agents; Antimetabolites, Antineoplastic; Arthritis, Rheumatoid; C-Reactive Protein; Double-Blind Method; Down-Regulation; Female; Humans; Interleukin-6; Janus Kinase 3; Male; Methotrexate; Middle Aged; Piperidines; Placebos; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Receptors, Interleukin-6; Serum Amyloid A Protein | 2014 |
Application of the Itch Severity Score in patients with moderate-to-severe plaque psoriasis: Clinically important difference and responder analyses.
Topics: Double-Blind Method; Humans; Piperidines; Pruritus; Psoriasis; Pyrimidines; Pyrroles; Treatment Outcome | 2015 |
Tofacitinib versus methotrexate in rheumatoid arthritis.
Topics: Administration, Oral; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Cholesterol; Creatinine; Dose-Response Relationship, Drug; Double-Blind Method; Female; Herpes Zoster; Humans; Janus Kinase 3; Male; Methotrexate; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles | 2014 |
A randomized study of H3 antagonist ABT-288 in mild-to-moderate Alzheimer's dementia.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Donepezil; Dose-Response Relationship, Drug; Double-Blind Method; Female; Follow-Up Studies; Histamine H3 Antagonists; Humans; Indans; Male; Middle Aged; Nootropic Agents; Piperidines; Psychiatric Status Rating Scales; Pyridazines; Pyrroles; Treatment Outcome | 2014 |
Changes in serum creatinine in patients with active rheumatoid arthritis treated with tofacitinib: results from clinical trials.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Creatinine; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Inflammation; Male; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles | 2014 |
Masitinib in advanced gastrointestinal stromal tumor (GIST) after failure of imatinib: a randomized controlled open-label trial.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Benzamides; Disease-Free Survival; Female; Gastrointestinal Stromal Tumors; Humans; Imatinib Mesylate; Indoles; Male; Middle Aged; Piperazines; Piperidines; Prospective Studies; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Pyridines; Pyrimidines; Pyrroles; Sunitinib; Thiazoles; Treatment Failure | 2014 |
Tofacitinib with methotrexate in third-line treatment of patients with active rheumatoid arthritis: patient-reported outcomes from a phase III trial.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Piperidines; Pyrimidines; Pyrroles; Self Report; Treatment Outcome | 2015 |
The JAK inhibitor tofacitinib suppresses synovial JAK1-STAT signalling in rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Chemokines; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Janus Kinase 1; Male; Matrix Metalloproteinase 1; Matrix Metalloproteinase 3; Methotrexate; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; RNA, Messenger; Signal Transduction; STAT Transcription Factors; Synovial Membrane; Treatment Outcome | 2015 |
Tofacitinib withdrawal and retreatment in moderate-to-severe chronic plaque psoriasis: a randomized controlled trial.
Topics: Adolescent; Adult; Aged; Chronic Disease; Dermatologic Agents; Double-Blind Method; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Patient Outcome Assessment; Piperidines; Protein Kinase Inhibitors; Psoriasis; Pyrimidines; Pyrroles; Quality of Life; Retreatment; Treatment Outcome; Young Adult | 2015 |
Potential mechanisms leading to the abnormal lipid profile in patients with rheumatoid arthritis versus healthy volunteers and reversal by tofacitinib.
Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Biomarkers; Cholesterol; Female; Healthy Volunteers; Humans; Hungary; Lipoproteins; Male; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Young Adult | 2015 |
Efficacy and safety of tofacitinib as monotherapy in Japanese patients with active rheumatoid arthritis: a 12-week, randomized, phase 2 study.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Female; Follow-Up Studies; Humans; Janus Kinase 3; Japan; Male; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Time Factors; Treatment Outcome | 2015 |
Randomized trial of tofacitinib in active ulcerative colitis: analysis of efficacy based on patient-reported outcomes.
Topics: Colitis, Ulcerative; Colonoscopy; Humans; Patient Preference; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Quality of Life; Remission Induction; Self Report; Severity of Illness Index | 2015 |
The effect of tofacitinib on pneumococcal and influenza vaccine responses in rheumatoid arthritis.
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Immunocompromised Host; Immunosuppressive Agents; Influenza Vaccines; Influenza, Human; Male; Methotrexate; Middle Aged; Piperidines; Pneumococcal Infections; Pneumococcal Vaccines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Young Adult | 2016 |
Evaluation of the effect of tofacitinib on measured glomerular filtration rate in patients with active rheumatoid arthritis: results from a randomised controlled trial.
Topics: Adult; Aged; Arthritis, Rheumatoid; Creatinine; Female; Glomerular Filtration Rate; Humans; Kidney; Male; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Young Adult | 2015 |
Effects of tofacitinib on lymphocyte sub-populations, CMV and EBV viral load in patients with plaque psoriasis.
Topics: Adult; C-Reactive Protein; Cytomegalovirus; DNA, Viral; Dose-Response Relationship, Drug; Female; Herpesvirus 4, Human; Humans; Lymphocyte Count; Lymphocyte Subsets; Male; Middle Aged; Piperidines; Protein Kinase Inhibitors; Psoriasis; Pyrimidines; Pyrroles; Viral Load | 2015 |
Tofacitinib versus etanercept or placebo in moderate-to-severe chronic plaque psoriasis: a phase 3 randomised non-inferiority trial.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Etanercept; Female; Humans; Immunoglobulin G; Male; Middle Aged; Piperidines; Protein Kinase Inhibitors; Psoriasis; Pyrimidines; Pyrroles; Receptors, Tumor Necrosis Factor; Treatment Outcome | 2015 |
Tofacitinib, an oral Janus kinase inhibitor, for the treatment of chronic plaque psoriasis: results from two randomized, placebo-controlled, phase III trials.
Topics: Administration, Oral; Adolescent; Adult; Aged; Chronic Disease; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Piperidines; Protein Kinase Inhibitors; Psoriasis; Pyrimidines; Pyrroles; Treatment Outcome; Young Adult | 2015 |
Randomized Pilot Clinical Trial of Tofacitinib Solution for Plaque Psoriasis: Challenges of the Intra-Subject Study Design.
Topics: Adult; Aged; Female; Humans; Male; Medication Adherence; Middle Aged; Pilot Projects; Piperidines; Protein Kinase Inhibitors; Psoriasis; Pyrimidines; Pyrroles; Research Design; Self Care; Severity of Illness Index | 2015 |
Efficacy and safety of tofacitinib following inadequate response to conventional synthetic or biological disease-modifying antirheumatic drugs.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Male; Methotrexate; Middle Aged; Piperidines; Pyrimidines; Pyrroles; Treatment Outcome | 2016 |
Correlation Between Concentrations of Fecal Calprotectin and Outcomes of Patients With Ulcerative Colitis in a Phase 2 Trial.
Topics: Administration, Oral; Adult; Area Under Curve; Biomarkers; Colitis, Ulcerative; Colonoscopy; Confidence Intervals; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Feces; Female; Follow-Up Studies; Humans; Leukocyte L1 Antigen Complex; Male; Middle Aged; Piperidines; Pyrimidines; Pyrroles; ROC Curve; Severity of Illness Index; Treatment Outcome; Young Adult | 2016 |
Effects of tofacitinib monotherapy on patient-reported outcomes in a randomized phase 3 study of patients with active rheumatoid arthritis and inadequate responses to DMARDs.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Middle Aged; Piperidines; Pyrimidines; Pyrroles; Quality of Life; Self Report; Surveys and Questionnaires; Treatment Outcome | 2015 |
Tofacitinib, an oral Janus kinase inhibitor, as monotherapy or with background methotrexate, in Japanese patients with rheumatoid arthritis: an open-label, long-term extension study.
Topics: Administration, Oral; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Janus Kinase 3; Japan; Male; Methotrexate; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Time Factors; Treatment Outcome | 2016 |
Oral tofacitinib efficacy, safety and tolerability in Japanese patients with moderate to severe plaque psoriasis and psoriatic arthritis: A randomized, double-blind, phase 3 study.
Topics: Administration, Oral; Adult; Aged; Arthritis, Psoriatic; Double-Blind Method; Female; Herpes Zoster; Humans; Japan; Male; Middle Aged; Piperidines; Protein Kinase Inhibitors; Psoriasis; Pyrimidines; Pyrroles; Treatment Outcome | 2016 |
Tofacitinib or adalimumab versus placebo: patient-reported outcomes from a phase 3 study of active rheumatoid arthritis.
Topics: Adalimumab; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Female; Humans; Male; Methotrexate; Middle Aged; Patient Reported Outcome Measures; Piperidines; Pyrimidines; Pyrroles; Quality of Life; Severity of Illness Index; Treatment Outcome | 2016 |
Extended-Release Once-Daily Formulation of Tofacitinib: Evaluation of Pharmacokinetics Compared With Immediate-Release Tofacitinib and Impact of Food.
Topics: Adult; Cross-Over Studies; Delayed-Action Preparations; Diet, High-Fat; Dietary Fats; Drug Administration Schedule; Drug Compounding; Food-Drug Interactions; Humans; Male; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles | 2016 |
Comparing the effects of tofacitinib, methotrexate and the combination, on bone marrow oedema, synovitis and bone erosion in methotrexate-naive, early active rheumatoid arthritis: results of an exploratory randomised MRI study incorporating semiquantitati
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Bone Density; Bone Marrow; Bone Marrow Diseases; Disease Progression; Double-Blind Method; Drug Therapy, Combination; Edema; Female; Hand; Humans; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Piperidines; Pyrimidines; Pyrroles; Synovitis; Treatment Outcome; Wrist Joint | 2016 |
Tofacitinib attenuates pathologic immune pathways in patients with psoriasis: A randomized phase 2 study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers; Biopsy; Double-Blind Method; Drug Administration Schedule; Female; Humans; Keratinocytes; Male; Middle Aged; Piperidines; Protein Kinase Inhibitors; Psoriasis; Pyrimidines; Pyrroles; Signal Transduction; Skin; Treatment Outcome; Young Adult | 2016 |
Safety, tolerability, and pharmacokinetics of single oral doses of tofacitinib, a Janus kinase inhibitor, in healthy volunteers.
Topics: Administration, Oral; Adult; Area Under Curve; Double-Blind Method; Drug Administration Schedule; Female; Half-Life; Healthy Volunteers; Humans; Janus Kinase Inhibitors; Male; Metabolic Clearance Rate; Middle Aged; Models, Biological; New Jersey; Piperidines; Pyrimidines; Pyrroles; Texas; Young Adult | 2015 |
The effect of mild and moderate hepatic impairment on the pharmacokinetics of tofacitinib, an orally active Janus kinase inhibitor.
Topics: Administration, Oral; Adult; Area Under Curve; Biotransformation; Cytochrome P-450 CYP2C19; Female; Florida; Genotype; Humans; Janus Kinase Inhibitors; Liver; Liver Diseases; Liver Function Tests; Male; Metabolic Clearance Rate; Middle Aged; Pharmacogenetics; Pharmacogenomic Variants; Phenotype; Piperidines; Pyrimidines; Pyrroles; Severity of Illness Index | 2014 |
Evaluation of the potential interaction between tofacitinib and drugs that undergo renal tubular secretion using metformin, an in vivo marker of renal organic cation transporter 2.
Topics: Administration, Oral; Adult; Area Under Curve; Belgium; Drug Interactions; Female; Healthy Volunteers; HEK293 Cells; Humans; Janus Kinase Inhibitors; Kidney Tubules; Male; Metformin; Middle Aged; Organic Cation Transporter 2; Piperidines; Pyrimidines; Pyrroles; Renal Elimination; Transfection; Young Adult | 2014 |
Single- and multiple-dose pharmacokinetics of tofacitinib in healthy Chinese volunteers.
Topics: Administration, Oral; Adult; Antineoplastic Agents; Area Under Curve; Asian People; China; Drug Administration Schedule; Female; Half-Life; Healthy Volunteers; Humans; Janus Kinase Inhibitors; Male; Metabolic Clearance Rate; Models, Biological; Piperidines; Pyrimidines; Pyrroles; Young Adult | 2015 |
Evaluation of the Effect of Tofacitinib on the Pharmacokinetics of Oral Contraceptive Steroids in Healthy Female Volunteers.
Topics: Adult; Area Under Curve; Contraceptives, Oral, Combined; Cross-Over Studies; Cytochrome P-450 CYP3A; Drug Combinations; Drug Interactions; Ethinyl Estradiol; Female; Half-Life; Humans; Levonorgestrel; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Young Adult | 2016 |
Efficacy of Tofacitinib for the Treatment of Moderate-to-Severe Chronic Plaque Psoriasis in Patient Subgroups from Two Randomised Phase 3 Trials.
Topics: Aged; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Piperidines; Protein Kinase Inhibitors; Psoriasis; Pyrimidines; Pyrroles; Severity of Illness Index; Treatment Outcome | 2016 |
Direct and Indirect Effects of Tofacitinib on Treatment Satisfaction in Patients with Ulcerative Colitis.
Topics: Adult; Anti-Inflammatory Agents; Colitis, Ulcerative; Double-Blind Method; Female; Humans; Male; Patient Satisfaction; Piperidines; Pyrimidines; Pyrroles; Remission Induction; Surveys and Questionnaires; Treatment Outcome | 2016 |
Tofacitinib versus etanercept or placebo in patients with moderate to severe chronic plaque psoriasis: patient-reported outcomes from a Phase 3 study.
Topics: Chronic Disease; Dermatologic Agents; Etanercept; Humans; Patient Satisfaction; Piperidines; Placebos; Psoriasis; Pyrimidines; Pyrroles; Treatment Outcome | 2016 |
Switching from adalimumab to tofacitinib in the treatment of patients with rheumatoid arthritis.
Topics: Adalimumab; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Substitution; Female; Humans; Male; Middle Aged; Piperidines; Pyrimidines; Pyrroles; Treatment Outcome | 2016 |
Topical tofacitinib for atopic dermatitis: a phase IIa randomized trial.
Topics: Adolescent; Adult; Dermatitis, Atopic; Double-Blind Method; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Ointments; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Treatment Outcome; Young Adult | 2016 |
Early clinical response to tofacitinib treatment as a predictor of subsequent efficacy: Results from two phase 3 studies of patients with moderate-to-severe plaque psoriasis.
Topics: Administration, Oral; Double-Blind Method; Female; Humans; Male; Middle Aged; Piperidines; Psoriasis; Pyrimidines; Pyrroles; ROC Curve; Severity of Illness Index; Treatment Outcome | 2017 |
Tofacitinib in Combination With Conventional Disease-Modifying Antirheumatic Drugs in Patients With Active Rheumatoid Arthritis: Patient-Reported Outcomes From a Phase III Randomized Controlled Trial.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Patient Reported Outcome Measures; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Recovery of Function; Remission Induction; Time Factors; Treatment Outcome | 2017 |
Effect of tofacitinib withdrawal and re-treatment on patient-reported outcomes: results from a Phase 3 study in patients with moderate to severe chronic plaque psoriasis.
Topics: Chronic Disease; Dermatologic Agents; Double-Blind Method; Humans; Piperidines; Psoriasis; Pyrimidines; Pyrroles; Quality of Life; Severity of Illness Index | 2017 |
Tofacitinib improves pruritus and health-related quality of life up to 52 weeks: Results from 2 randomized phase III trials in patients with moderate to severe plaque psoriasis.
Topics: Adult; Female; Humans; Male; Middle Aged; Pain; Patient Satisfaction; Piperidines; Protein Kinase Inhibitors; Pruritus; Psoriasis; Pyrimidines; Pyrroles; Quality of Life; Severity of Illness Index | 2016 |
Treatment of plaque psoriasis with an ointment formulation of the Janus kinase inhibitor, tofacitinib: a Phase 2b randomized clinical trial.
Topics: Adult; Aged; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Janus Kinases; Male; Middle Aged; Ointments; Piperidines; Protein Kinase Inhibitors; Psoriasis; Pyrimidines; Pyrroles; Young Adult | 2016 |
Efficacy of tofacitinib in patients with rheumatoid arthritis stratified by background methotrexate dose group.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; Disease Progression; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Janus Kinases; Male; Methotrexate; Middle Aged; Piperidines; Pyrimidines; Pyrroles; Regression Analysis; Surveys and Questionnaires; Treatment Outcome | 2017 |
Tofacitinib in patients with ankylosing spondylitis: a phase II, 16-week, randomised, placebo-controlled, dose-ranging study.
Topics: Adult; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Spondylitis, Ankylosing; Treatment Outcome | 2017 |
Efficacy of topical tofacitinib, a Janus kinase inhibitor, in the treatment of plaque psoriasis.
Topics: Administration, Cutaneous; Dermatologic Agents; Humans; Janus Kinase Inhibitors; Piperidines; Psoriasis; Pyrimidines; Pyrroles; Treatment Outcome | 2017 |
Tofacitinib for induction and maintenance therapy of Crohn's disease: results of two phase IIb randomised placebo-controlled trials.
Topics: Adult; C-Reactive Protein; Crohn Disease; Double-Blind Method; Female; Humans; Maintenance Chemotherapy; Male; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Remission Induction; Severity of Illness Index | 2017 |
Evaluating Dosage Optimality for Tofacitinib, an Oral Janus Kinase Inhibitor, in Plaque Psoriasis, and the Influence of Body Weight.
Topics: Administration, Oral; Body Weight; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Janus Kinase Inhibitors; Male; Middle Aged; Models, Biological; Piperidines; Psoriasis; Pyrimidines; Pyrroles; Treatment Outcome | 2017 |
Efficacy of tofacitinib for the treatment of nail psoriasis: Two 52-week, randomized, controlled phase 3 studies in patients with moderate-to-severe plaque psoriasis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Male; Middle Aged; Nail Diseases; Piperidines; Protein Kinase Inhibitors; Psoriasis; Pyrimidines; Pyrroles; Time Factors; Treatment Outcome; Young Adult | 2017 |
Estimated medical expenditure and risk of job loss among rheumatoid arthritis patients undergoing tofacitinib treatment: post hoc analyses of two randomized clinical trials.
Topics: Adalimumab; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Cost of Illness; Double-Blind Method; Drug Therapy, Combination; Female; Health Expenditures; Humans; Male; Methotrexate; Middle Aged; Piperidines; Pyrimidines; Pyrroles; Return to Work; Risk Factors; Treatment Outcome | 2017 |
Tofacitinib as Induction and Maintenance Therapy for Ulcerative Colitis.
Topics: Adult; Chi-Square Distribution; Colitis, Ulcerative; Double-Blind Method; Female; Humans; Induction Chemotherapy; Janus Kinases; Maintenance Chemotherapy; Male; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Remission Induction | 2017 |
Application of Physiologically-Based Pharmacokinetic Modeling for the Prediction of Tofacitinib Exposure in Japanese.
Topics: Adult; Asian People; Cross-Over Studies; Female; Healthy Volunteers; Humans; Male; Middle Aged; Models, Theoretical; Pharmacogenomic Variants; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; White People; Young Adult | 2017 |
The efficacy and safety of tofacitinib in Asian patients with moderate to severe chronic plaque psoriasis: A Phase 3, randomized, double-blind, placebo-controlled study.
Topics: Administration, Oral; Adult; Asian People; China; Double-Blind Method; Female; Humans; Janus Kinases; Male; Middle Aged; Piperidines; Protein Kinase Inhibitors; Psoriasis; Pyrimidines; Pyrroles; Republic of Korea; Severity of Illness Index; Taiwan; Treatment Outcome | 2017 |
Efficacy and safety of tofacitinib monotherapy, tofacitinib with methotrexate, and adalimumab with methotrexate in patients with rheumatoid arthritis (ORAL Strategy): a phase 3b/4, double-blind, head-to-head, randomised controlled trial.
Topics: Adalimumab; Administration, Oral; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Piperidines; Pyrimidines; Pyrroles; Severity of Illness Index; Treatment Outcome | 2017 |
Serum Human Beta-Defensin-2 Is a Possible Biomarker for Monitoring Response to JAK Inhibitor in Psoriasis Patients.
Topics: Adult; Aged; beta-Defensins; Biomarkers; Female; Humans; Janus Kinases; Male; Middle Aged; Piperidines; Protein Kinase Inhibitors; Psoriasis; Pyrimidines; Pyrroles; ROC Curve; Severity of Illness Index | 2017 |
Tofacitinib for the treatment of moderate to severe chronic plaque psoriasis in Japanese patients: Subgroup analyses from a randomized, placebo-controlled phase 3 trial.
Topics: Adult; Female; Humans; Male; Middle Aged; Piperidines; Protein Kinase Inhibitors; Psoriasis; Pyrimidines; Pyrroles | 2017 |
The Safety and Immunogenicity of Live Zoster Vaccination in Patients With Rheumatoid Arthritis Before Starting Tofacitinib: A Randomized Phase II Trial.
Topics: Aged; Antibodies, Viral; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Enzyme-Linked Immunosorbent Assay; Enzyme-Linked Immunospot Assay; Female; Herpes Zoster; Herpes Zoster Vaccine; Herpesvirus 3, Human; Humans; Immunogenicity, Vaccine; Immunoglobulin G; Male; Methotrexate; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; T-Lymphocytes | 2017 |
Reduction of Inflammatory and Cardiovascular Proteins in the Blood of Patients with Psoriasis: Differential Responses between Tofacitinib and Etanercept after 4 Weeks of Treatment.
Topics: Adult; Aged; Cardiovascular Diseases; Cytokines; Etanercept; Female; Humans; Inflammation; Male; Middle Aged; Piperidines; Protein Kinase Inhibitors; Proteomics; Psoriasis; Pyrimidines; Pyrroles; Risk Factors; Treatment Outcome; Young Adult | 2018 |
Comparison of effect of an increased dosage of vonoprazan versus vonoprazan plus lafutidine on gastric acid inhibition and serum gastrin.
Topics: Acetamides; Adolescent; Adult; Cross-Over Studies; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Gastric Acid; Gastric Acidity Determination; Gastrins; Gastroesophageal Reflux; Healthy Volunteers; Histamine H2 Antagonists; Humans; Hydrogen-Ion Concentration; Male; Piperidines; Proton Pump Inhibitors; Pyridines; Pyrroles; Sulfonamides; Young Adult | 2018 |
Tofacitinib in Patients with Ulcerative Colitis: Health-Related Quality of Life in Phase 3 Randomised Controlled Induction and Maintenance Studies.
Topics: Adult; Colitis, Ulcerative; Double-Blind Method; Female; Humans; Induction Chemotherapy; Janus Kinase Inhibitors; Maintenance Chemotherapy; Male; Middle Aged; Piperidines; Pyrimidines; Pyrroles; Quality of Life; Surveys and Questionnaires; Time Factors | 2018 |
Tofacitinib for Psoriatic Arthritis in Patients with an Inadequate Response to TNF Inhibitors.
Topics: Administration, Oral; Adult; Alanine Transaminase; Antirheumatic Agents; Arthritis, Psoriatic; Aspartate Aminotransferases; Disability Evaluation; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Janus Kinases; Male; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Treatment Failure; Tumor Necrosis Factor-alpha | 2017 |
Tofacitinib or Adalimumab versus Placebo for Psoriatic Arthritis.
Topics: Adalimumab; Administration, Oral; Adult; Antirheumatic Agents; Arthritis, Psoriatic; Disability Evaluation; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Janus Kinases; Male; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles | 2017 |
Effect of Glucocorticoids on the Clinical and Radiographic Efficacy of Tofacitinib in Patients with Rheumatoid Arthritis: A Posthoc Analysis of Data from 6 Phase III Studies.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Disability Evaluation; Disease Progression; Double-Blind Method; Drug Synergism; Drug Therapy, Combination; Female; Follow-Up Studies; Glucocorticoids; Health Surveys; Humans; Male; Methotrexate; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Treatment Outcome | 2018 |
Tofacitinib Therapy for Rheumatoid Arthritis: A Direct Comparison Study between Biologic-naïve and Experienced Patients.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Piperidines; Pyrimidines; Pyrroles; Severity of Illness Index; Treatment Outcome | 2018 |
Tofacitinib with conventional synthetic disease-modifying antirheumatic drugs in Chinese patients with rheumatoid arthritis: Patient-reported outcomes from a Phase 3 randomized controlled trial.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; China; Disability Evaluation; Double-Blind Method; Drug Administration Schedule; Drug Substitution; Drug Therapy, Combination; Female; Health Status; Humans; Male; Middle Aged; Pain Measurement; Patient Reported Outcome Measures; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Quality of Life; Recovery of Function; Time Factors; Treatment Outcome; Young Adult | 2018 |
Exposure-response characterization of tofacitinib efficacy in moderate to severe ulcerative colitis: Results from a dose-ranging phase 2 trial.
Topics: Adult; Aged; Anti-Inflammatory Agents; Colitis, Ulcerative; Dose-Response Relationship, Drug; Double-Blind Method; Female; Gastrointestinal Agents; Humans; Janus Kinase Inhibitors; Male; Middle Aged; Models, Biological; Piperidines; Pyrimidines; Pyrroles; Remission Induction; Severity of Illness Index; Treatment Outcome; Young Adult | 2018 |
CHK1 inhibition in soft-tissue sarcomas: biological and clinical implications.
Topics: Animals; Cell Line, Tumor; Checkpoint Kinase 1; Deoxycytidine; Dose-Response Relationship, Drug; Female; Gemcitabine; Genes, p53; Heterografts; Humans; Mice; Mice, Knockout; Mice, Nude; Mutation; Piperidines; Pyridines; Pyrroles; Soft Tissue Neoplasms; Tumor Suppressor Protein p53 | 2018 |
An Open-Label Pilot Study to Evaluate the Efficacy of Tofacitinib in Moderate to Severe Patch-Type Alopecia Areata, Totalis, and Universalis.
Topics: Adult; Alopecia Areata; Autoimmune Diseases; Biopsy; Dose-Response Relationship, Drug; Female; Gene Expression Profiling; Hair Follicle; Humans; Janus Kinase Inhibitors; Janus Kinases; Male; Middle Aged; Nitriles; Photography; Pilot Projects; Piperidines; Pyrazoles; Pyrimidines; Pyrroles; Severity of Illness Index; Treatment Outcome; Young Adult | 2018 |
Reversibility of peripheral blood leukocyte phenotypic and functional changes after exposure to and withdrawal from tofacitinib, a Janus kinase inhibitor, in healthy volunteers.
Topics: Adult; Aged; Arthritis, Rheumatoid; Female; Healthy Volunteers; Humans; Janus Kinase Inhibitors; Leukocytes; Lymphocyte Count; Male; Middle Aged; Phenotype; Piperidines; Pyrimidines; Pyrroles; T-Lymphocytes | 2018 |
Evaluation of disease activity in patients with rheumatoid arthritis treated with tofacitinib by RAPID3: post hoc analyses from two phase 3 trials.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Remission Induction; Treatment Outcome | 2018 |
Tofacitinib in Rheumatoid Arthritis: Lack of Early Change in Disease Activity and the Probability of Achieving Low Disease Activity at Month 6.
Topics: Adult; Aged; Arthritis, Rheumatoid; Disease Progression; Double-Blind Method; Female; Humans; Male; Middle Aged; Piperidines; Probability; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Time Factors; Treatment Outcome | 2019 |
Tofacitinib is associated with attainment of the minimally important reduction in axial magnetic resonance imaging inflammation in ankylosing spondylitis patients.
Topics: Adult; Disease Progression; Double-Blind Method; Female; Humans; Janus Kinase 3; Magnetic Resonance Imaging; Male; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Severity of Illness Index; Spondylitis, Ankylosing; Thoracic Vertebrae; Treatment Outcome | 2018 |
Association between serum interleukin-17A and clinical response to tofacitinib and etanercept in moderate to severe psoriasis.
Topics: Double-Blind Method; Etanercept; Female; Humans; Immunosuppressive Agents; Interleukin-17; Linear Models; Male; Piperidines; Protein Kinase Inhibitors; Psoriasis; Pyrimidines; Pyrroles; Remission Induction; Severity of Illness Index; Tumor Necrosis Factor-alpha | 2018 |
Tofacitinib in patients with moderate-to-severe chronic plaque psoriasis: long-term safety and efficacy in an open-label extension study.
Topics: Administration, Oral; Adult; Drug Administration Schedule; Drug-Related Side Effects and Adverse Reactions; Female; Follow-Up Studies; Humans; Janus Kinase 3; Male; Middle Aged; Piperidines; Protein Kinase Inhibitors; Psoriasis; Pyrimidines; Pyrroles; Severity of Illness Index; Time Factors; Treatment Outcome | 2018 |
Phase I study of the checkpoint kinase 1 inhibitor GDC-0575 in combination with gemcitabine in patients with refractory solid tumors.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Checkpoint Kinase 1; Deoxycytidine; Dose-Response Relationship, Drug; Drug Interactions; Fatigue; Female; Gemcitabine; Half-Life; Humans; Male; Maximum Tolerated Dose; Middle Aged; Nausea; Neoplasms; Neutropenia; Piperidines; Protein Kinase Inhibitors; Pyridines; Pyrroles; Thrombocytopenia; Treatment Outcome | 2018 |
Herpes Zoster Infection in Patients With Ulcerative Colitis Receiving Tofacitinib.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Colitis, Ulcerative; Female; Herpes Zoster; Herpesvirus 3, Human; Humans; Incidence; Male; Middle Aged; Piperidines; Prognosis; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; United States; Young Adult | 2018 |
Successful Treatment of Severe Alopecia Areata With Oral or Topical Tofacitinib.
Topics: Administration, Cutaneous; Administration, Oral; Adult; Alopecia Areata; Female; Follow-Up Studies; Hair Follicle; Humans; Male; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Treatment Outcome; Young Adult | 2018 |
Analysis of miRNA expression in patients with rheumatoid arthritis during remission and relapse after a 5-year trial of tofacitinib treatment.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; MicroRNAs; Middle Aged; Piperidines; Pyrimidines; Pyrroles; Recurrence | 2018 |
Tofacitinib, an oral Janus kinase inhibitor, in patients from Brazil with rheumatoid arthritis: Pooled efficacy and safety analyses.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; Brazil; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Janus Kinase Inhibitors; Male; Methotrexate; Middle Aged; Patient Reported Outcome Measures; Piperidines; Pyrimidines; Pyrroles; Treatment Outcome | 2018 |
Modified- versus immediate-release tofacitinib in Japanese rheumatoid arthritis patients: a randomized, phase III, non-inferiority study.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Delayed-Action Preparations; Double-Blind Method; Female; Humans; Janus Kinase Inhibitors; Japan; Male; Middle Aged; Piperidines; Pyrimidines; Pyrroles; Treatment Outcome | 2019 |
Treatment of alopecia universalis with topical Janus kinase inhibitors - a double blind, placebo, and active controlled pilot study.
Topics: Administration, Cutaneous; Alopecia; Clobetasol; Double-Blind Method; Glucocorticoids; Hair; Humans; Janus Kinase Inhibitors; Nitriles; Ointments; Pilot Projects; Piperidines; Prospective Studies; Pyrazoles; Pyrimidines; Pyrroles | 2018 |
A pooled analysis of the safety of tofacitinib as monotherapy or in combination with background conventional synthetic disease-modifying antirheumatic drugs in a Phase 3 rheumatoid arthritis population.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Piperidines; Pyrimidines; Pyrroles; Treatment Outcome; Young Adult | 2018 |
Disease-specific composite measures for psoriatic arthritis are highly responsive to a Janus kinase inhibitor treatment that targets multiple domains of disease.
Topics: Adalimumab; Antirheumatic Agents; Arthritis, Psoriatic; Drug Delivery Systems; Female; Humans; Injections, Subcutaneous; Janus Kinase Inhibitors; Longitudinal Studies; Male; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Treatment Outcome | 2018 |
Efficacy and Safety of Tofacitinib in Chinese Patients with Rheumatoid Arthritis.
Topics: Administration, Oral; Adult; Aged; Arthritis, Rheumatoid; Asian People; Female; Humans; Male; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Surveys and Questionnaires; Young Adult | 2018 |
Safety of Tofacitinib for Treatment of Ulcerative Colitis, Based on 4.4 Years of Data From Global Clinical Trials.
Topics: Adult; Aged; Colitis, Ulcerative; Colonoscopy; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Janus Kinase 3; Male; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Severity of Illness Index; Time Factors; Treatment Outcome | 2019 |
Systemic Tofacitinib Concentrations in Adult Patients With Atopic Dermatitis Treated With 2% Tofacitinib Ointment and Application to Pediatric Study Planning.
Topics: Adult; Dermatitis, Atopic; Double-Blind Method; Humans; Models, Biological; Ointments; Pediatrics; Piperidines; Pyrimidines; Pyrroles | 2019 |
Janus Kinase Inhibitors for the Treatment of Severe Alopecia Areata: An Open-Label Comparative Study.
Topics: Administration, Oral; Adolescent; Adult; Alopecia; Alopecia Areata; Female; Hair; Humans; Janus Kinase Inhibitors; Male; Middle Aged; Nitriles; Piperidines; Pyrazoles; Pyrimidines; Pyrroles; Recurrence; Severity of Illness Index; Time Factors; Young Adult | 2019 |
Long-term safety and tolerability of oral tofacitinib in patients with Crohn's disease: results from a phase 2, open-label, 48-week extension study.
Topics: Adult; Crohn Disease; Female; Humans; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles | 2019 |
Tofacitinib in Combination With Methotrexate in Patients With Rheumatoid Arthritis: Clinical Efficacy, Radiographic, and Safety Outcomes From a Twenty-Four-Month, Phase III Study.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Janus Kinase Inhibitors; Male; Methotrexate; Middle Aged; Piperidines; Pyrimidines; Pyrroles; Treatment Outcome | 2019 |
Tofacitinib or adalimumab versus placebo: patient-reported outcomes from OPAL Broaden-a phase III study of active psoriatic arthritis in patients with an inadequate response to conventional synthetic disease-modifying antirheumatic drugs.
Topics: Adalimumab; Adult; Antirheumatic Agents; Arthritis, Psoriatic; Female; Humans; Male; Middle Aged; Patient Reported Outcome Measures; Piperidines; Pyrimidines; Pyrroles; Treatment Outcome | 2019 |
Effect of tofacitinib on patient-reported outcomes in patients with active psoriatic arthritis and an inadequate response to tumour necrosis factor inhibitors in the phase III, randomised controlled trial: OPAL Beyond.
Topics: Arthritis, Psoriatic; Biomarkers; Female; Humans; Male; Patient Reported Outcome Measures; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor Inhibitors | 2019 |
Radiographic Progression According to Baseline C-reactive Protein Levels and Other Risk Factors in Psoriatic Arthritis Treated with Tofacitinib or Adalimumab.
Topics: Adalimumab; Adult; Antirheumatic Agents; Arthritis, Psoriatic; C-Reactive Protein; Disease Progression; Double-Blind Method; Female; Humans; Male; Middle Aged; Piperidines; Pyrimidines; Pyrroles; Risk Factors; Treatment Outcome | 2019 |
Treatment outcomes in patients with seropositive versus seronegative rheumatoid arthritis in Phase III randomised clinical trials of tofacitinib.
Topics: Adult; Aged; Aged, 80 and over; Anti-Citrullinated Protein Antibodies; Arthritis, Rheumatoid; Biomarkers; Female; Humans; Janus Kinase Inhibitors; Male; Middle Aged; Patient Reported Outcome Measures; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Rheumatoid Factor; Risk Factors; Treatment Outcome; Young Adult | 2019 |
Safety and efficacy of tofacitinib for up to 9.5 years in the treatment of rheumatoid arthritis: final results of a global, open-label, long-term extension study.
Topics: Administration, Oral; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cardiovascular Diseases; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Herpes Zoster; Humans; Male; Middle Aged; Neoplasms; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Time Factors; Treatment Outcome | 2019 |
Live Zoster Vaccine in Patients With Rheumatoid Arthritis Treated With Tofacitinib With or Without Methotrexate, or Adalimumab With Methotrexate: A Post Hoc Analysis of Data From a Phase IIIb/IV Randomized Study.
Topics: Adalimumab; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Herpes Zoster; Herpes Zoster Vaccine; Humans; Incidence; Janus Kinase Inhibitors; Male; Methotrexate; Middle Aged; Piperidines; Pyrimidines; Pyrroles | 2020 |
Tofacitinib in Amyopathic Dermatomyositis-Associated Interstitial Lung Disease.
Topics: Adult; Autoantibodies; Dermatomyositis; Drug Therapy, Combination; Female; Glucocorticoids; Historically Controlled Study; Humans; Interferon-Induced Helicase, IFIH1; Janus Kinase Inhibitors; Lung Diseases, Interstitial; Male; Methylprednisolone; Middle Aged; Piperidines; Pyrimidines; Pyrroles | 2019 |
Population pharmacokinetics of tofacitinib in patients with psoriatic arthritis
.
Topics: Adolescent; Adult; Aged; Arthritis, Psoriatic; Female; Humans; Male; Middle Aged; Piperidines; Pyrimidines; Pyrroles; Young Adult | 2019 |
Very early MRI responses to therapy as a predictor of later radiographic progression in early rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Magnetic Resonance Imaging; Male; Methotrexate; Piperidines; Predictive Value of Tests; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Treatment Outcome | 2019 |
Efficacy and safety of tofacitinib dose de-escalation and dose escalation for patients with ulcerative colitis: results from OCTAVE Open.
Topics: Adult; Colitis, Ulcerative; Dose-Response Relationship, Drug; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Maintenance Chemotherapy; Male; Middle Aged; Piperidines; Pyrimidines; Pyrroles; Remission Induction; Treatment Outcome | 2020 |
Patient-reported outcomes for tofacitinib with and without methotrexate, or adalimumab with methotrexate, in rheumatoid arthritis: a phase IIIB/IV trial.
Topics: Adalimumab; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Middle Aged; Piperidines; Pyrimidines; Pyrroles; Severity of Illness Index; Treatment Outcome | 2019 |
Early phase 2 trial of TAS-205 in patients with Duchenne muscular dystrophy.
Topics: Child; Child, Preschool; Enzyme Inhibitors; Humans; Intramolecular Oxidoreductases; Male; Morpholines; Muscular Dystrophy, Duchenne; Outcome Assessment, Health Care; Piperidines; Pyrroles | 2020 |
A pilot study of tofacitinib for refractory Behçet's syndrome.
Topics: Adult; Behcet Syndrome; Female; Humans; Male; Middle Aged; Pilot Projects; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles | 2020 |
Associations between Patient Global Assessment scores and pain, physical function, and fatigue in rheumatoid arthritis: a post hoc analysis of data from phase 3 trials of tofacitinib.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Fatigue; Humans; Pain; Piperidines; Pyrimidines; Pyrroles; Treatment Outcome | 2020 |
Efficacy and Safety of Extended Induction With Tofacitinib for the Treatment of Ulcerative Colitis.
Topics: Colitis, Ulcerative; Humans; Piperidines; Pyrimidines; Pyrroles; Remission Induction; Treatment Outcome | 2022 |
Long-term safety of tofacitinib up to 9.5 years: a comprehensive integrated analysis of the rheumatoid arthritis clinical development programme.
Topics: Adult; Arthritis, Rheumatoid; Humans; Piperidines; Pyrimidines; Pyrroles; Treatment Outcome | 2020 |
Atogepant Is Not Associated With Clinically Meaningful Alanine Aminotransferase Elevations in Healthy Adults.
Topics: Administration, Oral; Adult; Alanine Transaminase; Dose-Response Relationship, Drug; Double-Blind Method; Female; Healthy Volunteers; Humans; Liver; Liver Function Tests; Male; Middle Aged; Migraine Disorders; Piperidines; Placebos; Pyridines; Pyrroles; Spiro Compounds; Young Adult | 2021 |
Single-Dose Pharmacokinetics and Safety of Atogepant in Adults With Hepatic Impairment: Results From an Open-Label, Phase 1 Trial.
Topics: Administration, Oral; Aged; Calcitonin Gene-Related Peptide Receptor Antagonists; Female; Half-Life; Humans; Liver Diseases; Male; Middle Aged; Piperidines; Pyridines; Pyrroles; Severity of Illness Index; Spiro Compounds | 2021 |
Efficacy and Safety of Tofacitinib in Ulcerative Colitis Based on Prior Tumor Necrosis Factor Inhibitor Failure Status.
Topics: Colitis, Ulcerative; Humans; Piperidines; Pyrimidines; Pyrroles; Treatment Outcome; Tumor Necrosis Factor Inhibitors | 2022 |
A Single Supratherapeutic Dose of Atogepant Does Not Affect Cardiac Repolarization in Healthy Adults: Results From a Randomized, Single-Dose, Phase 1 Crossover Trial.
Topics: Adolescent; Adult; Area Under Curve; Calcitonin Gene-Related Peptide Receptor Antagonists; Cross-Over Studies; Double-Blind Method; Electrocardiography; Female; Humans; Long QT Syndrome; Male; Moxifloxacin; Piperidines; Pyridines; Pyrroles; Spiro Compounds; Young Adult | 2021 |
Sublingual tofacitinib for alopecia areata: a roll-over pilot clinical trial and analysis of pharmacokinetics.
Topics: Alopecia Areata; Humans; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Treatment Outcome | 2021 |
Atogepant for the Preventive Treatment of Migraine.
Topics: Adolescent; Adult; Aged; Calcitonin Gene-Related Peptide Receptor Antagonists; Constipation; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Intention to Treat Analysis; Male; Middle Aged; Migraine Disorders; Nausea; Piperidines; Pyridines; Pyrroles; Spiro Compounds; Young Adult | 2021 |
Differences and similarities in clinical and functional responses among patients receiving tofacitinib monotherapy, tofacitinib plus methotrexate, and adalimumab plus methotrexate: a post hoc analysis of data from ORAL Strategy.
Topics: Adalimumab; Antirheumatic Agents; Drug Therapy, Combination; Humans; Methotrexate; Piperidines; Pyrimidines; Pyrroles; Treatment Outcome | 2021 |
Time course of efficacy of atogepant for the preventive treatment of migraine: Results from the randomized, double-blind ADVANCE trial.
Topics: Analgesics; Double-Blind Method; Humans; Migraine Disorders; Piperidines; Pyridines; Pyrroles; Spiro Compounds; Treatment Outcome | 2022 |
Literature Commentary.
Topics: Aged; Aspirin; Humans; Ophthalmology; Piperidines; Pyridines; Pyrroles; Retrospective Studies; Spiro Compounds; Stroke | 2021 |
Atogepant and sumatriptan: no clinically relevant drug-drug interactions in a randomized, open-label, crossover trial.
Topics: Adult; Area Under Curve; Cross-Over Studies; Drug Interactions; Humans; Piperidines; Pyridines; Pyrroles; Spiro Compounds; Sumatriptan | 2022 |
Predictors of Sustained Response With Tofacitinib Therapy in Patients With Ulcerative Colitis.
Topics: Child; Colitis, Ulcerative; Humans; Piperidines; Pyrimidines; Pyrroles; Remission Induction | 2022 |
Tofacitinib and risk of cardiovascular outcomes: results from the Safety of TofAcitinib in Routine care patients with Rheumatoid Arthritis (STAR-RA) study.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Piperidines; Pyrimidines; Pyrroles; Treatment Outcome; Tumor Necrosis Factor Inhibitors | 2022 |
An Evaluation of Efficacy and Safety of Tofacitinib, A JAK Inhibitor in the Management of Hospitalized Patients with Mild to Moderate COVID-19 - An Open-Label Randomized Controlled Study.
Topics: Adult; COVID-19; Humans; Immunomodulating Agents; Janus Kinase Inhibitors; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; RNA, Viral; SARS-CoV-2; Treatment Outcome | 2022 |
Impact of Tofacitinib on Components of the ACR Response Criteria: Post Hoc Analysis of Phase III and Phase IIIb/IV Trials.
Topics: Adalimumab; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Piperidines; Pyrimidines; Pyrroles; Rheumatology; Treatment Outcome; United States | 2022 |
Exposure-Response Characterization of Tofacitinib Efficacy in Moderate to Severe Ulcerative Colitis: Results From Phase II and Phase III Induction and Maintenance Studies.
Topics: Colitis, Ulcerative; Humans; Piperidines; Pyrimidines; Pyrroles; Remission Induction | 2022 |
The impact of tofacitinib on fatigue, sleep, and health-related quality of life in patients with rheumatoid arthritis: a post hoc analysis of data from Phase 3 trials.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Fatigue; Humans; Methotrexate; Piperidines; Pyrimidines; Pyrroles; Quality of Life; Sleep; Treatment Outcome | 2022 |
Efficacy of tofacitinib in patients with rheumatoid arthritis stratified by baseline body mass index: an analysis of pooled data from phase 3 studies.
Topics: Adult; Arthritis, Rheumatoid; Body Mass Index; Humans; Piperidines; Pyrimidines; Pyrroles | 2022 |
Effect of tofacitinib on pain, fatigue, health-related quality of life and work productivity in patients with active ankylosing spondylitis: results from a phase III, randomised, double-blind, placebo-controlled trial.
Topics: Adult; Antirheumatic Agents; Fatigue; Humans; Pain; Piperidines; Pyrimidines; Pyrroles; Quality of Life; Spondylitis, Ankylosing; Treatment Outcome | 2022 |
Rates of Response to Atogepant for Migraine Prophylaxis Among Adults: A Secondary Analysis of a Randomized Clinical Trial.
Topics: Adult; Analgesics; Double-Blind Method; Female; Humans; Male; Migraine Disorders; Piperidines; Pyridines; Pyrroles; Spiro Compounds; Treatment Outcome | 2022 |
Infections in patients with rheumatoid arthritis receiving tofacitinib versus tumour necrosis factor inhibitors: results from the open-label, randomised controlled ORAL Surveillance trial.
Topics: Analgesics, Opioid; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Female; Humans; Lung Diseases; Piperidines; Pyrimidines; Pyrroles; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha | 2022 |
Tofacitinib blocks IFN-regulated biomarker genes in skin fibroblasts and keratinocytes in a systemic sclerosis trial.
Topics: Biomarkers; Endothelial Cells; Fibroblasts; Humans; Keratinocytes; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Scleroderma, Systemic; Treatment Outcome | 2022 |
Tofacitinib as a maintenance therapy in patients with ulcerative colitis stratified by OCTAVE Sustain baseline Mayo endoscopic subscore.
Topics: Colitis, Ulcerative; Humans; Piperidines; Pyrimidines; Pyrroles; Treatment Outcome | 2023 |
Continuation, reduction, or withdrawal of tofacitinib in patients with rheumatoid arthritis achieving sustained disease control: a multicenter, open-label, randomized controlled trial.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; China; Humans; Piperidines; Pyrroles; Quality of Life; Treatment Outcome | 2023 |
Patient-reported migraine-specific quality of life, activity impairment and headache impact with once-daily atogepant for preventive treatment of migraine in a randomized, 52-week trial.
Topics: Calcitonin Gene-Related Peptide Receptor Antagonists; Drug Administration Schedule; Humans; Migraine Disorders; Patient Reported Outcome Measures; Piperidines; Pyridines; Pyrroles; Quality of Life; Spiro Compounds | 2023 |
727 other study(ies) available for pyrroles and piperidines
| Article | Year |
|---|---|
[Hydrogenated pyrrolo(2,3-b)pyridines (author's transl)].
Topics: Edetic Acid; Mercury; Methods; Piperidines; Pyridines; Pyrroles | 1976 |
Veratridine activates a silent sodium channel in rat isolated aorta.
Topics: Amiloride; Animals; Aorta; Benzothiazoles; Calcium; Guanidine; Guanidines; In Vitro Techniques; Piperidines; Pyrroles; Rats; Sodium Channels; Tetrodotoxin; Thiazoles; Vasodilator Agents; Veratridine | 1992 |
Potassium channel openers, NIP-121 and cromakalim, enhance the relaxation induced by sodium nitroprusside in the guinea-pig isolated trachea.
Topics: Animals; Benzopyrans; Cromakalim; Cyclic GMP; Drug Interactions; Epithelium; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Nitroprusside; Oxadiazoles; Piperidines; Potassium Channels; Pyrroles; SRS-A; Trachea; Vasodilator Agents | 1992 |
Modulation of guinea-pig tracheal smooth muscle responsiveness by the potassium channel openers NIP-121 and cromakalim.
Topics: Animals; Benzopyrans; Cromakalim; Guinea Pigs; In Vitro Techniques; Muscle, Smooth; Oxadiazoles; Piperidines; Potassium Channels; Pyrroles; Trachea; Vasodilator Agents | 1992 |
Effects of anti-asthma drugs and potassium channel openers on neurally-mediated contraction of isolated guinea pig trachea.
Topics: Acetylcholine; Aminophylline; Animals; Benzopyrans; Cromakalim; Electric Stimulation; Guinea Pigs; Hydrocortisone; Isoproterenol; Male; Muscle Contraction; Muscle, Smooth; Oxadiazoles; Piperidines; Potassium Channels; Pyrroles; Trachea | 1992 |
Veratridine-induced intoxication in the isolated left atrium of the rat: effects of some anti-ischemic compounds.
Topics: Animals; Atrial Function, Left; Benzothiazoles; Calcium; Coronary Disease; Dose-Response Relationship, Drug; Heart; In Vitro Techniques; Male; Piperidines; Pyrroles; Rats; Sodium; Sodium Channels; Thiazoles; Veratridine | 1991 |
The antihypertensive property of NIP-121, a novel potassium channel opener in rats.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Benzopyrans; Blood Pressure; Cromakalim; Dose-Response Relationship, Drug; Heart Rate; Injections, Intravenous; Male; Oxadiazoles; Piperidines; Potassium Channels; Pyrroles; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Rats, Inbred WKY; Species Specificity | 1991 |
Action potential shortening and negative inotropic effects of a novel potassium channel opener, NIP-121, as compared with cromakalim in guinea pig ventricular myocardium.
Topics: Action Potentials; Animals; Antihypertensive Agents; Benzopyrans; Cromakalim; Depression, Chemical; Guinea Pigs; Heart Rate; Heart Ventricles; Male; Myocardial Contraction; Oxadiazoles; Piperidines; Potassium Channels; Pyrroles | 1991 |
NIP-121 and cromakalim, potassium channel openers, preferentially suppress prostanoid-induced contraction of the guinea-pig isolated trachea.
Topics: Animals; Arachidonic Acid; Benzopyrans; Cromakalim; Dinoprost; Glyburide; Guinea Pigs; Indomethacin; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Oxadiazoles; Piperidines; Potassium Channels; Prostaglandin D2; Prostaglandin Endoperoxides, Synthetic; Prostaglandins; Pyrroles; Sulfonamides; Trachea | 1991 |
Potassium channel opening properties of a novel compound, NIP-121, cromakalim and nicorandil in rat aorta and portal vein.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Benzopyrans; Cromakalim; Glyburide; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Oxadiazoles; Phentolamine; Piperidines; Portal Vein; Potassium Channels; Potassium Chloride; Pyrroles; Rats; Rats, Inbred Strains; Rubidium Radioisotopes | 1991 |
Effect of potassium channel blockade on the anti-ischemic actions of mechanistically diverse agents.
Topics: Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Benzopyrans; Coronary Circulation; Coronary Disease; Cromakalim; Glyburide; Lidocaine; Male; Piperidines; Potassium Channels; Pyridines; Pyrroles; Rats; Rats, Inbred Strains | 1991 |
Determination of fluparoxan (GR50360) in plasma by gas chromatography.
Topics: Antidepressive Agents; Chromatography, Gas; Half-Life; Humans; Molecular Structure; Piperidines; Piperoxan; Pyrroles; Quality Control | 1990 |
Application of electron spin resonance to the study of the structure of human serum lipoproteins.
Topics: Amino Acids; Binding Sites; Chemical Phenomena; Chemistry; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Free Radicals; Humans; Lipoproteins; Methods; Piperidines; Pyrroles; Thiocyanates; Ultracentrifugation | 1969 |
Effect of nucleotides and pyrophosphate on spin labels bound to S1 thiol groups of myosin.
Topics: Adenine Nucleotides; Adenosine Triphosphatases; Adenosine Triphosphate; Binding Sites; Calcium; Cyclic N-Oxides; Diphosphates; Electron Spin Resonance Spectroscopy; Enzyme Activation; Ethylmaleimide; Free Radicals; Iodoacetates; Muscle Proteins; Nucleotides; Optical Rotatory Dispersion; Piperidines; Potassium; Protein Binding; Pyrroles; Sulfhydryl Compounds; Trypsin | 1970 |
Urea denaturation of active-site spin-labeled -chymotrypsin.
Topics: Binding Sites; Chymotrypsin; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Fluorine; Hydrogen-Ion Concentration; Organophosphorus Compounds; Piperidines; Protein Denaturation; Pyrroles; Urea | 1972 |
Spin-labeled sulfonyl fluorides as active site probes of protease structure. I. Comparison of the active site environments in alpha-chymotrypsin and trypsin.
Topics: Amidines; Benzene Derivatives; Benzenesulfonates; Binding Sites; Chemical Phenomena; Chemistry; Chymotrypsin; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Fluorine; Hydrogen-Ion Concentration; Indoles; Isomerism; Models, Structural; Piperidines; Protein Conformation; Pyrroles; Pyrrolidines; Structure-Activity Relationship; Tosyl Compounds; Trypsin; Trypsin Inhibitors | 1974 |
[Autoradiographic studies on the distribution of the thioxanthene derivative 14C-BP 400 in the rat brain].
Topics: Animals; Autoradiography; Brain; Brain Chemistry; Carbon Isotopes; Histamine H1 Antagonists; Hypnotics and Sedatives; Male; Piperidines; Pyrroles; Rats; Thalamus; Xanthenes | 1970 |
Bibliography of paper and thin-layer chromatography 1966-1969. Other compounds with heterocyclic nitrogen.
Topics: Animals; Bibliographies as Topic; Bile Pigments; Carboxylic Acids; Chromatography; Chromatography, Paper; Chromatography, Thin Layer; Heterocyclic Compounds; Hydrocarbons; Imidazoles; Indoles; Isoquinolines; Nitrogen; Piperidines; Plants; Pyrazoles; Pyridines; Pyrroles; Quinolines | 1972 |
Comparative in vitro hepatic metabolism of some tertiary N-methyl tobacco alkaloids in various species.
Topics: Alkaloids; Animals; Chromatography, Gas; Chromatography, Paper; Cricetinae; Cyclic N-Oxides; Dealkylation; Female; Guinea Pigs; In Vitro Techniques; Liver; Male; Methylation; Mice; Nicotiana; Nicotine; Oxidation-Reduction; Piperidines; Plants, Toxic; Pyridines; Pyrroles; Rabbits; Rats; Species Specificity; Stereoisomerism; Time Factors | 1973 |
[Change in the amine composition of the volatile substances in the vaginal secretions of American mink (Mustela vison) in relation to the sexual cycle].
Topics: Amines; Animal Communication; Animals; Butylamines; Chromatography, Gas; Estrus; Ethylamines; Female; Methylamines; Mink; Picolines; Piperidines; Pregnancy; Propylamines; Pyridines; Pyrroles; Vagina | 1974 |
Structural requirements for nicotine and cyclic imine-induced amine release from neoplastic mast cells.
Topics: Amines; Animals; Azetines; Azirines; Cell Line; Chemical Phenomena; Chemistry; Electrons; Hydrogen-Ion Concentration; Imidazoles; Imines; Kinetics; Mast Cells; Mice; Mice, Inbred Strains; Neoplasms; Nicotine; Piperidines; Pyrroles; Pyrrolidines; Serotonin; Solubility; Spectrometry, Fluorescence; Structure-Activity Relationship | 1974 |
Reaction gas chromatography. 3. Recognition of tropane structure in alkaloids.
Topics: Alkaloids; Atropine; Catalysis; Chemical Phenomena; Chemistry; Chromatography, Gas; Cocaine; Nortropanes; Piperidines; Pyridines; Pyrroles; Pyrrolidines; Scopolamine; Toluene | 1967 |
K+ channel openers produce epithelium-dependent relaxation of the guinea-pig trachea.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arginine; Benzopyrans; Cromakalim; Epithelium; Guinea Pigs; Male; Methylene Blue; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Oxadiazoles; Piperidines; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Thromboxane A2; Trachea; Vasoactive Intestinal Peptide | 1995 |
Comparative study of vasodilator effects of the potassium channel openers NIP-121 and levcromakalim in dogs and rats.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Anesthesia; Animals; Benzopyrans; Coronary Circulation; Cromakalim; Dogs; Female; Hemodynamics; Male; Oxadiazoles; Piperidines; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Rats; Rats, Wistar; Thromboxane A2; Vasoconstrictor Agents; Vasodilator Agents | 1995 |
Potassium channel openers relax A23187-induced nifedipine-resistant contraction of rat aorta.
Topics: Animals; Aorta; Benzopyrans; Calcimycin; Cromakalim; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nifedipine; Oxadiazoles; Piperidines; Pyrroles; Rats; Rats, Wistar; Vasoconstriction; Vasodilator Agents | 1994 |
K+ channel-opening properties of a novel compound, NIP-121, in guinea pig myocardium as compared with those of cromakalim.
Topics: Action Potentials; Adenosine Triphosphate; Analysis of Variance; Animals; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Guinea Pigs; Hypoglycemic Agents; Muscle Relaxation; Muscle, Smooth, Vascular; Myocardial Contraction; Myocardium; Oxadiazoles; Papillary Muscles; Patch-Clamp Techniques; Piperidines; Potassium Channels; Pyrroles; Vasodilator Agents | 1995 |
Effect of the K+ channel openers NIP-121 and cromakalim on melittin-induced relaxation of guinea-pig isolated trachea.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Benzopyrans; Cromakalim; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Activation; Epithelium; Guinea Pigs; Histamine; Indomethacin; Leukotriene D4; Male; Melitten; Muscle Relaxation; Muscle, Smooth; Oxadiazoles; Phospholipases A; Phospholipases A2; Piperidines; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Thromboxane A2; Trachea | 1996 |
Aroyl(aminoacyl)pyrroles, a new class of anticonvulsant agents.
Topics: Anesthesia; Animals; Anticonvulsants; Bicuculline; Calcium; Cerebellum; Electroshock; Mice; Models, Molecular; Molecular Structure; Pentylenetetrazole; Piperidines; Potassium; Pyrroles; Rats; Seizures; Structure-Activity Relationship; Veratridine | 1997 |
Effects of gastroprokinetic agents on gastroparesis in streptozotocin-induced diabetic rats.
Topics: Animals; Benzamides; Benzimidazoles; Blood Glucose; Cisapride; Diabetes Mellitus, Experimental; Gastric Emptying; Gastrointestinal Motility; Gastroparesis; Granisetron; Male; Morpholines; Ondansetron; Piperidines; Pyrroles; Rats; Rats, Wistar; Serotonin Antagonists; Serotonin Receptor Agonists; Vagotomy | 1997 |
Delta-1-piperideine-6-carboxylate dehydrogenase, a new enzyme that forms alpha-aminoadipate in Streptomyces clavuligerus and other cephamycin C-producing actinomycetes.
Topics: 2-Aminoadipic Acid; Bacterial Proteins; Cephamycins; Chromatography, Thin Layer; Electrophoresis, Polyacrylamide Gel; Enzyme Stability; Kinetics; L-Lysine 6-Transaminase; Lysine; Molecular Weight; NAD; Oxidoreductases Acting on CH-NH Group Donors; Picolinic Acids; Pipecolic Acids; Piperidines; Pyrroles; Quaternary Ammonium Compounds; Streptomyces; Substrate Specificity; Transaminases | 1997 |
Dopamine D4 receptor and anxiety: behavioural profiles of clozapine, L-745,870 and L-741,742 in the mouse plus-maze.
Topics: Animals; Anti-Anxiety Agents; Antipsychotic Agents; Anxiety; Chlordiazepoxide; Clozapine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Isoxazoles; Male; Maze Learning; Mice; Piperidines; Pyridines; Pyrroles; Receptors, Dopamine D4 | 1997 |
In the search for new anticancer drugs. 29. A study on the correlation of lipophilicities, ionization constants and anticancer activities of aminoxyl labeled TEPA congeners.
Topics: Antineoplastic Agents; Chemical Phenomena; Chemistry, Physical; Hydrogen-Ion Concentration; Ions; Kinetics; Molecular Conformation; Piperidines; Potentiometry; Pyrroles; Pyrrolidines; Structure-Activity Relationship; Triethylenephosphoramide | 1998 |
The agonist activities of the putative antipsychotic agents, L-745,870 and U-101958 in HEK293 cells expressing the human dopamine D4.4 receptor.
Topics: Aminopyridines; Antipsychotic Agents; Cell Line; Clozapine; Colforsin; Cyclic AMP; Dopamine; Dopamine Agonists; Dopamine Antagonists; Humans; Kidney; Piperidines; Pyridines; Pyrroles; Raclopride; Receptors, Dopamine D2; Receptors, Dopamine D4; Recombinant Proteins; Salicylamides; Spiperone | 1998 |
Human D2 and D4 dopamine receptors couple through betagamma G-protein subunits to inwardly rectifying K+ channels (GIRK1) in a Xenopus oocyte expression system: selective antagonism by L-741,626 and L-745,870 respectively.
Topics: Dopamine Antagonists; Dopamine D2 Receptor Antagonists; GTP-Binding Proteins; Humans; Indoles; Ion Channel Gating; Membrane Potentials; Oocytes; Patch-Clamp Techniques; Piperidines; Potassium Channel Blockers; Pyridines; Pyrroles; Receptors, Dopamine D4 | 1998 |
D4 dopamine receptor-mediated phospholipid methylation and its implications for mental illnesses such as schizophrenia.
Topics: Amino Acid Sequence; Aminopyridines; Animals; Benzazepines; Binding Sites; Carbon Radioisotopes; CHO Cells; Clozapine; Cricetinae; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Formates; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Methionine; Mutagenesis, Site-Directed; Neuroblastoma; Phospholipids; Phosphorylation; Piperidines; Psychotic Disorders; Pyridines; Pyrroles; Raclopride; Receptors, Dopamine D2; Receptors, Dopamine D4; Recombinant Proteins; S-Adenosylmethionine; Salicylamides; Schizophrenia; Transfection; Tumor Cells, Cultured | 1999 |
Receptor density as a factor governing the efficacy of the dopamine D4 receptor ligands, L-745,870 and U-101958 at human recombinant D4.4 receptors expressed in CHO cells.
Topics: Aminopyridines; Animals; Butyrates; CHO Cells; Cricetinae; Cyclic AMP; Dopamine Agents; Humans; Ligands; Piperidines; Pyridines; Pyrroles; Radioligand Assay; Receptors, Dopamine D2; Receptors, Dopamine D4; Recombinant Proteins; Spiperone | 1999 |
Discovery of subtype-selective NMDA receptor ligands: 4-benzyl-1-piperidinylalkynylpyrroles, pyrazoles and imidazoles as NR1A/2B antagonists.
Topics: Animals; Disease Models, Animal; Imidazoles; Levodopa; Ligands; Molecular Structure; Oxidopamine; Parkinsonian Disorders; Piperidines; Pyrazoles; Pyrroles; Rats; Receptors, N-Methyl-D-Aspartate | 1999 |
Effects of selective dopamine D4 receptor blockers, NRA0160 and L-745,870, on A9 and A10 dopamine neurons in rats.
Topics: Animals; Antipsychotic Agents; Dopamine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Male; Neurons; Piperidines; Pyridines; Pyrroles; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, Dopamine D4; Substantia Nigra; Thiazoles; Ventral Tegmental Area | 1999 |
NK(2)-receptor mediated contraction in monkey, guinea-pig and human airway smooth muscle.
Topics: Animals; Benzamides; Bronchi; Bronchoconstriction; Cryopreservation; Female; Guinea Pigs; Humans; Indoles; Macaca fascicularis; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Piperidines; Pyrroles; Pyrrolidines; Receptors, Neurokinin-2; Species Specificity | 1999 |
[2-(omega-phenylalkyl)phenoxy]alkylamines.II: Synthesis and selective serotonin-2 receptor binding.
Topics: Animals; Blood Platelets; Blood Vessels; Humans; In Vitro Techniques; Ketanserin; Phenyl Ethers; Piperidines; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyrroles; Rats; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, beta; Receptors, Dopamine D2; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Receptors, Serotonin, 5-HT3; Serotonin Antagonists; Structure-Activity Relationship; Succinates; Vasoconstriction | 2000 |
S33084, a novel, potent, selective, and competitive antagonist at dopamine D(3)-receptors: I. Receptorial, electrophysiological and neurochemical profile compared with GR218,231 and L741,626.
Topics: Animals; Benzopyrans; Brain; Dopamine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Enzyme Activation; Guanosine 5'-O-(3-Thiotriphosphate); Indoles; Male; Mitogen-Activated Protein Kinases; Norepinephrine; Oxazines; Piperidines; Pyrroles; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, Dopamine D3; Serotonin; Sulfones; Tetrahydronaphthalenes | 2000 |
S33084, a novel, potent, selective, and competitive antagonist at dopamine D(3)-receptors: II. Functional and behavioral profile compared with GR218,231 and L741,626.
Topics: Animals; Behavior, Animal; Benzopyrans; Body Temperature; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Extrapyramidal Tracts; Indoles; Male; Mice; Motor Activity; Oxazines; Piperidines; Psychotropic Drugs; Pyrroles; Rats; Rats, Wistar; Receptors, Dopamine D3; Sulfones; Tetrahydronaphthalenes | 2000 |
[(3)H]PNU-101958, a D(4) dopamine receptor probe, accumulates in prefrontal cortex and hippocampus of non-human primate brain.
Topics: Aminopyridines; Animals; Autoradiography; Brain; Hippocampus; Macaca mulatta; Molecular Probes; Piperidines; Prefrontal Cortex; Pyridines; Pyrroles; Receptors, Dopamine D2; Receptors, Dopamine D4; Tissue Distribution; Tritium | 2000 |
Dopamine D1 receptors synergize with D2, but not D3 or D4, receptors in the striatum without the involvement of action potentials.
Topics: Action Potentials; Amphetamine; Animals; Corpus Striatum; Dopamine Antagonists; Genes, fos; Indans; Indoles; Male; Piperidines; Proto-Oncogene Proteins c-fos; Pyridines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptor Cross-Talk; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Dopamine D3; Receptors, Dopamine D4; Tetrodotoxin | 2000 |
Synthesis and screening for antiacetylcholinesterase activity of (1-benzyl-4-oxopiperidin-3-ylidene)methylindoles and -pyrroles related to donepezil.
Topics: Acetylcholinesterase; Donepezil; Drug Evaluation, Preclinical; Indans; Indoles; Luminescent Measurements; Models, Molecular; Nootropic Agents; Piperidines; Pyrroles; Structure-Activity Relationship | 2001 |
Protein kinase MARK/PAR-1 is required for neurite outgrowth and establishment of neuronal polarity.
Topics: Amino Acid Motifs; Animals; Azepines; Cell Line; Cell Polarity; Enzyme Inhibitors; Flavonoids; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Mice; Neurites; Neurons; Piperidines; Protein Serine-Threonine Kinases; Pyrroles; Recombinant Fusion Proteins; Signal Transduction; tau Proteins | 2002 |
New N-n-propyl-substituted 3-aryl- and 3-cyclohexylpiperidines as partial agonists at the D4 dopamine receptor.
Topics: Animals; Binding, Competitive; Corpus Striatum; Crystallography, X-Ray; Dopamine Agonists; Guanine Nucleotides; Guinea Pigs; In Vitro Techniques; Male; Melatonin; Piperidines; Purine Nucleosides; Pyrimidinones; Pyrroles; Radioligand Assay; Receptors, Dopamine D2; Receptors, Dopamine D4; Retina; Structure-Activity Relationship | 2003 |
Lipid-lowering effects of TAK-475, a squalene synthase inhibitor, in animal models of familial hypercholesterolemia.
Topics: Administration, Oral; Animals; Atorvastatin; Cholesterol, HDL; Disease Models, Animal; Enzyme Inhibitors; Farnesyl-Diphosphate Farnesyltransferase; Female; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipoproteinemia Type II; Male; Mice; Mice, Knockout; Oxazepines; Piperidines; Pyrroles; Rabbits; Receptors, LDL; Simvastatin; Species Specificity; Time Factors; Triglycerides | 2003 |
Drugs in the news: an analysis of Canadian newspaper coverage of new prescription drugs.
Topics: Acetamides; Advertising; Anti-Inflammatory Agents, Non-Steroidal; Anticholesteremic Agents; Antiviral Agents; Atorvastatin; Bibliometrics; Canada; Celecoxib; Cholinesterase Inhibitors; Consumer Product Safety; Disclosure; Donepezil; Drug Industry; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Estrogen Antagonists; Heptanoic Acids; Humans; Indans; Newspapers as Topic; Oseltamivir; Patient Education as Topic; Piperidines; Pyrazoles; Pyrroles; Raloxifene Hydrochloride; Sulfonamides | 2003 |
Control by tachykinin NK(2) receptors of CRF(1) receptor-mediated activation of hippocampal acetylcholine release in the rat and guinea-pig.
Topics: Acetylcholine; Animals; Benzamides; Dose-Response Relationship, Drug; Guinea Pigs; Hippocampus; Injections, Intraventricular; Male; Microdialysis; Neurokinin-1 Receptor Antagonists; Physical Stimulation; Piperidines; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; Receptors, Neurokinin-2; Species Specificity; Stereoisomerism; Tetrazoles | 2003 |
Pharmacological and functional characterisation of dopamine D4 receptors in the rat retina.
Topics: Animals; Binding Sites; Cyclic AMP; Darkness; Dopamine Agonists; Dopamine Antagonists; In Vitro Techniques; Indoles; Male; Piperidines; Pyridines; Pyrroles; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Dopamine D4; Retina; Spiperone | 2003 |
Evidence for regulation of body temperature in rats by dopamine D2 receptor and possible influence of D1 but not D3 and D4 receptors.
Topics: Animals; Aporphines; Benzazepines; Benzopyrans; Body Temperature Regulation; Dopamine Agonists; Dopamine Antagonists; Hypothermia; Indoles; Oxazines; Piperazines; Piperidines; Pyridines; Pyrimidines; Pyrroles; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Dopamine D3; Receptors, Dopamine D4 | 2003 |
S+ -flurbiprofen but not 5-HT1 agonists suppress basal and stimulated CGRP and PGE2 release from isolated rat dura mater.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcitonin Gene-Related Peptide; Culture Media, Conditioned; Dinoprostone; Drug Interactions; Dura Mater; Flurbiprofen; Immunoassay; In Vitro Techniques; Indoles; Inflammation Mediators; Male; Piperidines; Pyridines; Pyrroles; Rats; Rats, Wistar; Serotonin Receptor Agonists; Time Factors; Tryptamines | 2003 |
Novel potent 5-HT(1F) receptor agonists: structure-activity studies of a series of substituted N-[3-(1-methyl-4-piperidinyl)-1H-pyrrolo[3,2-b]pyridin-5-yl]amides.
Topics: Administration, Oral; Animals; Blood Proteins; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; In Vitro Techniques; Migraine Disorders; Piperidines; Polyunsaturated Alkamides; Pyridines; Pyrroles; Rabbits; Radioligand Assay; Receptor, Serotonin, 5-HT1F; Receptors, Serotonin; Saphenous Vein; Serotonin Receptor Agonists; Structure-Activity Relationship; Trigeminal Nerve; Vasoconstriction | 2003 |
Diverse regulation of atrial natriuretic peptide secretion by serotonin receptor subtypes.
Topics: Adenylyl Cyclase Inhibitors; Alkaloids; Aminobenzoates; Animals; Atrial Natriuretic Factor; Benzophenanthridines; Benzothiazoles; Calcium; Carbazoles; Cyclic AMP-Dependent Protein Kinases; Depression, Chemical; Dose-Response Relationship, Drug; Heart; Heart Atria; Imines; Indoles; Isoquinolines; Ketanserin; Male; Myocytes, Cardiac; Neomycin; para-Aminobenzoates; Perfusion; Phenanthridines; Piperazines; Piperidines; Protein Kinase C; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT4; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Staurosporine; Sulfonamides; Thiazoles; Type C Phospholipases | 2003 |
Plant enzyme reactions leading to the formation of heterocyclic compounds. 1. The formation of unsaturated pyrrolidine and piperidine compounds.
Topics: Oxidoreductases; Piperidines; Plants; Pyrroles; Pyrrolidines | 1955 |
Plant enzyme reactions leading to the formation of heterocyclic compounds. 3. Plant amine oxidase and the formation of pyrrolidine and piperidine alkaloids.
Topics: Alkaloids; Amines; Oxidoreductases; Piperidines; Pyrroles; Pyrrolidines | 1959 |
[ENZYMATIC SYNTHESES OF PYRROLIDINE- AND PIPERIDINE ALKALOIDS].
Topics: Alkaloids; Amines; Piperidines; Pyrroles; Pyrrolidines | 1963 |
RETENTION OF ALIPHATIC AMINES IN URAEMIA.
Topics: Amines; Ammonia; Blood; Body Fluids; Cerebrospinal Fluid; Chromatography; Dinitrophenols; Geriatrics; Humans; Piperidines; Pyrroles; Urea; Uremia; Urine; Urologic Diseases | 1963 |
REACTIONS OF QUINOLINE 1-OXIDE WITH ENAMINES OF CYCLOHEXANONE.
Topics: Chemistry, Pharmaceutical; Cyclohexanes; Cyclohexanones; Morpholines; Oxides; Piperidines; Pyrroles; Quinolines; Research | 1963 |
[ADDITIONAL CLASSES OF COMPOUNDS INHIBITING TUMORS. I. CYTOSTATIC EFFECTS OF N- AND S-HYDROXYMETHYL COMPOUNDS].
Topics: Amides; Animals; Antineoplastic Agents; Benzimidazoles; Carbohydrate Metabolism; Carcinoma, Ehrlich Tumor; Cytostatic Agents; Formaldehyde; Hydantoins; Imidazoles; Isonicotinic Acids; Mice; Morpholines; Neoplasms, Experimental; Niacin; Niacinamide; Piperazines; Piperidines; Pyrroles; Research; Urea | 1963 |
HYPOTENSIVES. VI. DISUBSTITUTED ALKYLENEDIAMINES AND RELATED COMPOUNDS.
Topics: Amines; Antihypertensive Agents; Chemistry, Pharmaceutical; Dogs; Ethylenediamines; Pharmacology; Piperidines; Pyridines; Pyrroles; Rats; Research; Thiophenes | 1963 |
SOME 2-SUBSTITUTED AMINOPURINES AND PURINE ANALOGS.
Topics: 2-Aminopurine; Animals; Antineoplastic Agents; Chemistry, Pharmaceutical; Leukemia; Leukemia, Experimental; Morpholines; Pharmacology; Piperidines; Purines; Pyrimidines; Pyrroles; Research; Sarcoma 180 | 1963 |
PIPERIDINO GROUPS IN ANTITUSSIVE ACTIVITY.
Topics: Anti-Allergic Agents; Antitussive Agents; Camphor; Cats; Chemistry, Pharmaceutical; Dogs; Histamine H1 Antagonists; Morpholines; Pharmacology; Phenethylamines; Phenothiazines; Piperidines; Pyrroles; Research; Sympatholytics; Toxicology | 1963 |
DETERMINATION OF PYRROLIDINE AND PIPERIDINE.
Topics: Chromatography; Piperidines; Pyrroles; Pyrrolidines; Research; Spectrophotometry | 1964 |
[ON NEW WORKS ON THE BIOSYNTHESIS OF N-HETEROCYCLIC COMPOUNDS. 4. THE FORMATION OF COMPOUNDS WITH THE PYRIDINE-, PIPERIDINE-, QUINOLIZIDINE-, PYRROLIZIDINE- AND TROPANE RING SYSTEMS].
Topics: Chemistry, Pharmaceutical; Heterocyclic Compounds; Nortropanes; Piperidines; Pyridines; Pyrroles; Quinolizidines; Quinolizines; Research; Tropanes | 1964 |
N,N'-THIOCARBONYLBIS(CYCLIC NITROGEN HETEROPARAFFINS).
Topics: Chemistry, Pharmaceutical; Heterocyclic Compounds; Morpholines; Nitrogen; Pharmacy; Piperazines; Piperidines; Pyrroles; Quinolines; Research | 1964 |
The actions of heterocyclic bisquaternary compounds, especially of a pyrrolidinium series.
Topics: Autonomic Agents; Heterocyclic Compounds; Piperidines; Pyrroles | 1955 |
New evidence on the mechanisms underlying bradykinin-mediated contraction of the pig iris sphincter in vitro.
Topics: Animals; Benzamides; Bradykinin; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Calcium; Calcium Channels; Capsaicin; Carbazoles; Conotoxins; Dipeptides; Dose-Response Relationship, Drug; Egtazic Acid; In Vitro Techniques; Indoles; Iris; Maleimides; Muscle Contraction; Nicardipine; omega-Agatoxin IVA; Peptide Fragments; Piperidines; Protein Kinase Inhibitors; Protein Kinases; Pyrroles; Receptors, Calcitonin Gene-Related Peptide; Receptors, Drug; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Swine; Tachykinins | 2003 |
Prevention of organ allograft rejection by a specific Janus kinase 3 inhibitor.
Topics: Animals; Enzyme Inhibitors; Gene Expression Regulation; Graft Rejection; Graft Survival; Heart Transplantation; Humans; Immunosuppressive Agents; Interleukin-2; Janus Kinase 3; Kidney Transplantation; Lymphocyte Activation; Lymphocyte Count; Lymphocyte Culture Test, Mixed; Lymphocyte Subsets; Macaca fascicularis; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Myocardium; Piperidines; Protein-Tyrosine Kinases; Pyrimidines; Pyrroles; Transplantation, Heterotopic; Transplantation, Homologous; Tumor Cells, Cultured | 2003 |
Delayed stress-induced colonic hypersensitivity in male Wistar rats: role of neurokinin-1 and corticotropin-releasing factor-1 receptors.
Topics: Animals; Colon; Electromyography; Fear; Hypersensitivity, Delayed; Immunohistochemistry; Indoles; Isoindoles; Male; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Nociceptors; Physical Stimulation; Piperidines; Pyrimidines; Pyrroles; Quinuclidines; Rats; Rats, Wistar; Receptors, Corticotropin-Releasing Hormone; Receptors, Neurokinin-1; Stress, Psychological; Sympathectomy, Chemical; Sympathetic Nervous System | 2004 |
A new class of potent non-imidazole H(3) antagonists: 2-aminoethylbenzofurans.
Topics: Amines; Animals; Benzofurans; Central Nervous System; Histamine Antagonists; Humans; Imidazoles; Molecular Structure; Piperidines; Pyrroles; Pyrrolidines; Rats; Receptors, Histamine H3; Structure-Activity Relationship | 2004 |
Isoform-selectivity of PKC inhibitors acting at the regulatory and catalytic domain of mammalian PKC-alpha, -betaI, -delta, -eta and -zeta.
Topics: Acetophenones; Alkaloids; Animals; Benzophenanthridines; Benzopyrans; Catalysis; Enzyme Inhibitors; Escherichia coli; Indoles; Isoenzymes; Phenanthridines; Piperidines; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-alpha; Protein Kinase C-delta; Pyrroles; Saccharomyces cerevisiae; Sphingosine; Tamoxifen; Yeasts | 2003 |
Cleavage of some annulated tetrahydropyridines under the action of dimethyl acetylene dicarboxylate in protic solvents. New practical route to substituted pyrroles and indoles.
Topics: Acetylene; Alcohols; Carboxylic Acids; Dioxanes; Indoles; Molecular Structure; Piperidines; Pyridines; Pyrroles; Solvents | 2003 |
Zebrafish: a preclinical model for drug screening.
Topics: Acridine Orange; Alkaline Phosphatase; Angiogenesis Inhibitors; Animals; Apoptosis; Biological Assay; Drug Evaluation, Preclinical; Embryo, Nonmammalian; Flavonoids; Fluorescent Dyes; Indoles; Lethal Dose 50; Mice; Piperidines; Pyrroles; Toxicity Tests; Zebrafish | 2002 |
The JAK3 inhibitor CP-690550 selectively reduces NK and CD8+ cell numbers in cynomolgus monkey blood following chronic oral dosing.
Topics: Administration, Oral; Animals; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; B-Lymphocytes; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Count; Dose-Response Relationship, Drug; Down-Regulation; Drug Administration Schedule; Enzyme Inhibitors; Female; Graft Rejection; Graft Survival; Humans; Immune Tolerance; Immunosuppression Therapy; Interleukin-15; Janus Kinase 3; Killer Cells, Natural; Lectins, C-Type; Macaca fascicularis; Male; Piperidines; Protein-Tyrosine Kinases; Pyrimidines; Pyrroles | 2004 |
Immunosuppression by the JAK3 inhibitor CP-690,550 delays rejection and significantly prolongs kidney allograft survival in nonhuman primates.
Topics: Administration, Oral; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Flow Cytometry; Graft Rejection; Graft Survival; Immunosuppression Therapy; Immunosuppressive Agents; Intracellular Signaling Peptides and Proteins; Janus Kinase 3; Kidney; Kidney Transplantation; Leukocyte Count; Lymphocytes; Macaca fascicularis; Piperidines; Protein-Tyrosine Kinases; Pyrimidines; Pyrroles; Time Factors; Transplantation, Homologous | 2005 |
In vitro procoagulant activity induced in endothelial cells by chemotherapy and antiangiogenic drug combinations: modulation by lower-dose chemotherapy.
Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Blood Coagulation; Cells, Cultured; Cisplatin; Deoxycytidine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Synergism; Endothelial Cells; Gemcitabine; Humans; Indoles; Oxindoles; Piperidines; Propionates; Pyrroles; Quinazolines; Thromboplastin | 2005 |
Quantitative analysis of the immunosuppressant CP-690,550 in whole blood by column-switching high-performance liquid chromatography and mass spectrometry detection.
Topics: Animals; Chromatography, High Pressure Liquid; Drug Monitoring; Immunosuppressive Agents; Janus Kinase 3; Macaca fascicularis; Male; Piperidines; Protein-Tyrosine Kinases; Pyrimidines; Pyrroles; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization | 2005 |
Stereoselective synthesis and glycosidase inhibitory activity of 3,4-dihydroxy-pyrrolidin-2-one, 3,4-dihydroxy-piperidin-2-one and 1,2-dihydroxy-pyrrolizidin-3-one.
Topics: Crystallography, X-Ray; Cyclization; Drug Design; Enzyme Inhibitors; Glycoside Hydrolases; Models, Molecular; Molecular Structure; Piperidines; Pyrroles; Pyrrolidinones; Stereoisomerism; Structure-Activity Relationship | 2006 |
Effects of JAK3 inhibition with CP-690,550 on immune cell populations and their functions in nonhuman primate recipients of kidney allografts.
Topics: Animals; Cell Proliferation; Immune System; Interferon-gamma; Interleukin-2; Janus Kinase 3; Kidney Transplantation; Killer Cells, Natural; Leukocyte Count; Lymphocyte Activation; Macaca fascicularis; Male; Piperidines; Protein-Tyrosine Kinases; Pyrimidines; Pyrroles; T-Lymphocytes | 2005 |
Combined use of the JAK3 inhibitor CP-690,550 with mycophenolate mofetil to prevent kidney allograft rejection in nonhuman primates.
Topics: Animals; Graft Survival; Janus Kinase 3; Kidney Transplantation; Macaca fascicularis; Models, Animal; Mycophenolic Acid; Piperidines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrimidines; Pyrroles | 2005 |
Sigma2 (sigma2) receptors as a target for cocaine action in the rat striatum.
Topics: Animals; Benzylamines; Calcium; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; In Vitro Techniques; Indoles; Male; Maleimides; Mesylates; N-Methylaspartate; Nomifensine; Pentazocine; Piperidines; Protein Kinase C; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, sigma; Sigma-1 Receptor; Spiro Compounds; Sulfonamides; Tritium | 2006 |
Synthesis, pharmacology, and structure-activity relationships of novel imidazolones and pyrrolones as modulators of GABAA receptors.
Topics: Administration, Oral; Animals; Anti-Anxiety Agents; Anticonvulsants; Binding Sites; Brain; GABA Antagonists; GABA-A Receptor Agonists; Imidazoles; Male; Mice; Models, Molecular; Morpholines; Pentylenetetrazole; Piperidines; Pyrroles; Quantitative Structure-Activity Relationship; Radioligand Assay; Rats; Rats, Wistar; Rotarod Performance Test; Seizures | 2006 |
3-(4-Piperidinyl)indoles and 3-(4-piperidinyl)pyrrolo-[2,3-b]pyridines as ligands for the ORL-1 receptor.
Topics: Binding Sites; Indoles; Ligands; Molecular Structure; Nociceptin Receptor; Piperidines; Pyridines; Pyrroles; Receptors, Opioid; Structure-Activity Relationship | 2006 |
High performance liquid chromatographic analysis of MS23 piperidine analog MSP001 in rat plasma.
Topics: Animals; Antihypertensive Agents; Calibration; Chromatography, High Pressure Liquid; Drug Stability; Female; Injections, Intravenous; Piperidines; Pyrroles; Rats; Rats, Sprague-Dawley; Reference Standards; Reproducibility of Results; Sensitivity and Specificity | 2006 |
ZD6474 induces growth arrest and apoptosis of GIST-T1 cells, which is enhanced by concomitant use of sunitinib.
Topics: Adaptor Proteins, Signal Transducing; Antineoplastic Agents; Apoptosis; Cell Cycle Proteins; Cell Proliferation; Drug Therapy, Combination; Gastrointestinal Stromal Tumors; Humans; Indoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphoproteins; Phosphorylation; Piperidines; Protein Kinases; Proto-Oncogene Proteins c-akt; Pyrroles; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Ribosomal Protein S6 Kinases, 70-kDa; STAT3 Transcription Factor; Sunitinib; TOR Serine-Threonine Kinases; Tumor Cells, Cultured | 2006 |
Simplified analogues of immucillin-G retain potent human purine nucleoside phosphorylase inhibitory activity.
Topics: Antineoplastic Agents; Cell Line; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Piperidines; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; Pyrrolidines; Structure-Activity Relationship | 2006 |
Janus kinase 3 inhibition with CP-690,550 prevents allograft vasculopathy.
Topics: Animals; Aorta; Arteriosclerosis; Chemokine CCL5; Hyperplasia; Interferon-gamma; Janus Kinase 3; Killer Cells, Natural; Male; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Rats; Rats, Inbred ACI; Rats, Inbred Lew; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins; Transplantation, Homologous; Tunica Intima | 2006 |
Constrained analogs of CB-1 antagonists: 1,5,6,7-Tetrahydro-4H-pyrrolo[3,2-c]pyridine-4-one derivatives.
Topics: Animals; Anti-Obesity Agents; Body Weight; Crystallography, X-Ray; Drug Design; Eating; Humans; Magnetic Resonance Spectroscopy; Male; Models, Molecular; Obesity; Piperidines; Pyrazoles; Pyridones; Pyrroles; Rats; Rats, Wistar; Rats, Zucker; Receptor, Cannabinoid, CB1; Rimonabant; Structure-Activity Relationship; Weight Gain | 2007 |
Arthritis clinical trial results revealed.
Topics: Acetates; Antirheumatic Agents; Arthritis, Rheumatoid; Chondroitin Sulfates; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Osteoarthritis; Piperidines; Pyrimidines; Pyrroles | 2007 |
Reaction between diiodide anion radicals in ionic liquids.
Topics: Anions; Cations; Electrons; Ethanol; Free Radicals; Iodides; Ionic Liquids; Methanol; Piperidines; Pyrroles; Quaternary Ammonium Compounds; Static Electricity; Time Factors; Water | 2007 |
5-((4-Aminopiperidin-1-yl)methyl)pyrrolotriazine dual inhibitors of EGFR and HER2 protein tyrosine kinases.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Cell Line, Tumor; Chemistry, Pharmaceutical; Drug Design; Drug Screening Assays, Antitumor; ErbB Receptors; Humans; Inhibitory Concentration 50; Insecta; Models, Chemical; Neoplasm Transplantation; Neoplasms; Piperidines; Pyrroles; Receptor, ErbB-2; Triazines | 2007 |
Studies on the interactions between lactam analogs and the N-terminal extracellular tail of CC chemokine receptor 4 by CZE.
Topics: Amino Acid Motifs; Amino Acid Sequence; Electrophoresis, Capillary; Molecular Sequence Data; Piperidines; Pyrroles; Receptors, CCR4; Stereoisomerism | 2007 |
Urocortin I is present in the enteric nervous system and exerts an excitatory effect via cholinergic and serotonergic pathways in the rat colon.
Topics: Animals; Atropine; Colon; Corticotropin-Releasing Hormone; Dioxanes; Electric Stimulation; Enteric Nervous System; Gastrointestinal Motility; Hexamethonium; Immunohistochemistry; Male; NG-Nitroarginine Methyl Ester; Ondansetron; Peptide Fragments; Piperidines; Pyrimidines; Pyrroles; Rats; Receptors, Corticotropin-Releasing Hormone; Serotonin 5-HT3 Receptor Antagonists; Serotonin 5-HT4 Receptor Antagonists; Tetrodotoxin; Urocortins | 2007 |
Some pharmacological actions of piperidine, pyrrolidine, and of pressor concentrates from dog urine.
Topics: Animals; Dogs; Piperidines; Pyrroles; Pyrrolidines; Quinidine | 1949 |
Cartilage preservation by inhibition of Janus kinase 3 in two rodent models of rheumatoid arthritis.
Topics: Adjuvants, Immunologic; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Cartilage, Articular; Collagen; Dose-Response Relationship, Drug; Enzyme Inhibitors; Interleukin-6; Janus Kinase 3; Male; Mice; Mice, Inbred DBA; Piperidines; Pyrimidines; Pyrroles; Rats; Rats, Inbred Lew | 2008 |
The JAK-3 inhibitor CP-690550 is a potent anti-inflammatory agent in a murine model of pulmonary eosinophilia.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; B-Lymphocytes; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Dose-Response Relationship, Drug; Eosinophils; Female; Flow Cytometry; Histocompatibility Antigens Class II; In Vitro Techniques; Interleukin-4; Janus Kinase 3; Mice; Mice, Inbred BALB C; Mice, Knockout; Ovalbumin; Piperidines; Pulmonary Eosinophilia; Pyrimidines; Pyrroles; Receptors, IgE; Th2 Cells | 2008 |
Memantine increases brain production of kynurenic acid via protein kinase A-dependent mechanism.
Topics: Analysis of Variance; Animals; Animals, Newborn; Brain; Carbazoles; Cells, Cultured; Chromatography, High Pressure Liquid; Cyclic AMP-Dependent Protein Kinases; Dopamine Agents; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; In Vitro Techniques; Isoquinolines; Kynurenic Acid; Male; Memantine; Neurons; Piperidines; Pyrroles; Rats; Rats, Wistar | 2008 |
The JAK kinase inhibitor CP-690,550 suppresses the growth of human polycythemia vera cells carrying the JAK2V617F mutation.
Topics: Animals; Apoptosis; Blotting, Western; Bone Marrow; Cell Cycle; Cell Nucleus; Cell Proliferation; Cells, Cultured; Erythroid Precursor Cells; Erythropoietin; Flow Cytometry; Humans; Immunoprecipitation; Janus Kinase 2; Membrane Potential, Mitochondrial; Mice; Mutation; Phosphorylation; Piperidines; Polycythemia Vera; Protein Kinase Inhibitors; Protein Transport; Pyrimidines; Pyrroles; Receptors, Erythropoietin; Signal Transduction; STAT3 Transcription Factor | 2008 |
Kinesin spindle protein (KSP) inhibitors. 9. Discovery of (2S)-4-(2,5-difluorophenyl)-n-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide (MK-0731) for the treatment of taxane-refractory can
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Enzyme Inhibitors; Humans; Kinesins; Neoplasms; Piperidines; Pyrroles; Taxoids | 2008 |
Commentary on "the Atorvastatin/Donepezil in Alzheimer's Disease Study (LEADe): design and baseline characteristics".
Topics: Alzheimer Disease; Anticholesteremic Agents; Atorvastatin; Cholinesterase Inhibitors; Donepezil; Drug Therapy, Combination; Heptanoic Acids; Humans; Indans; Multicenter Studies as Topic; Piperidines; Pyrroles; Randomized Controlled Trials as Topic | 2008 |
Blockade of dopamine D(3) receptors in frontal cortex, but not in sub-cortical structures, enhances social recognition in rats: similar actions of D(1) receptor agonists, but not of D(2) antagonists.
Topics: Animals; Benzazepines; Benzopyrans; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Indoles; Male; Microinjections; Nitriles; Piperidines; Prefrontal Cortex; Pyrroles; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D3; Recognition, Psychology; Social Behavior; Tetrahydroisoquinolines | 2009 |
Examining the chirality, conformation and selective kinase inhibition of 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile (CP-690,550).
Topics: Chemistry, Pharmaceutical; Drug Design; Humans; Hydrogen Bonding; Inhibitory Concentration 50; Janus Kinase 2; Kinetics; Models, Chemical; Models, Molecular; Molecular Conformation; Monte Carlo Method; Piperidines; Protein Binding; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Stereoisomerism | 2008 |
Endocannabinoid-dependent plasticity at GABAergic and glutamatergic synapses in the striatum is regulated by synaptic activity.
Topics: Action Potentials; Animals; Arachidonic Acids; Calcium Channel Agonists; Calcium Channels, L-Type; Cannabinoid Receptor Modulators; Endocannabinoids; Female; gamma-Aminobutyric Acid; Glutamic Acid; Male; Neostriatum; Neuronal Plasticity; Neurons; Organ Culture Techniques; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Pyrroles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Synapses; Synaptic Transmission | 2009 |
HPLC/MS/MS analysis of 3-carbamyl-4-methylpyrrole analog MNP001, a highly potent antihypertensive agent, in rat plasma.
Topics: Animals; Antihypertensive Agents; Chromatography, High Pressure Liquid; Piperidines; Pyrroles; Rats; Sensitivity and Specificity; Tandem Mass Spectrometry | 2009 |
Metal-catalyzed cycloisomerization reactions of cis-4-hydroxy-5-alkynylpyrrolidinones and cis-5-hydroxy-6-alkynylpiperidinones: synthesis of furo[3,2-b]pyrroles and furo[3,2-b]pyridines.
Topics: Alkynes; Catalysis; Cyclization; Metals, Heavy; Molecular Structure; Piperidines; Pyridines; Pyrroles; Pyrrolidines; Stereoisomerism | 2009 |
Overhauser dynamic nuclear polarization and molecular dynamics simulations using pyrroline and piperidine ring nitroxide radicals.
Topics: Computer Simulation; Electron Spin Resonance Spectroscopy; Free Radicals; Indicators and Reagents; Models, Molecular; Nitrogen Oxides; Piperidines; Protons; Pyrroles; Reactive Nitrogen Species; Spin Labels; Water | 2009 |
D2 dopamine receptor subtype-mediated hyperactivity and amphetamine responses in a model of ADHD.
Topics: Amphetamine; Animals; Attention Deficit Disorder with Hyperactivity; Benzopyrans; Corpus Striatum; Dihydroxyphenylalanine; Disease Models, Animal; Dopamine; Dopamine Agents; Dopamine D2 Receptor Antagonists; Extracellular Space; Indoles; Locomotion; Mice; Mice, Knockout; Mice, Mutant Strains; Piperidines; Pyridines; Pyrroles; Receptors, Dopamine D2; Receptors, Dopamine D3; Receptors, Dopamine D4 | 2010 |
Mechanism of action of an imidopiperidine inhibitor of human polynucleotide kinase/phosphatase.
Topics: Adenosine Triphosphate; Antineoplastic Agents, Phytogenic; Binding Sites; Camptothecin; Cell Survival; Circular Dichroism; DNA Ligase ATP; DNA Ligases; DNA Polymerase beta; DNA Repair; DNA Repair Enzymes; Drug Resistance, Neoplasm; Enzyme Inhibitors; Etoposide; Fluorescence Resonance Energy Transfer; Humans; Lung Neoplasms; Mutagenesis, Site-Directed; Phosphotransferases (Alcohol Group Acceptor); Photoelectron Spectroscopy; Piperidines; Poly-ADP-Ribose Binding Proteins; Protein Conformation; Pyrroles; Radiation-Sensitizing Agents; Tumor Cells, Cultured; Xenopus Proteins | 2010 |
Analysis of anti-proliferative and chemosensitizing effects of sunitinib on human esophagogastric cancer cells: Synergistic interaction with vandetanib via inhibition of multi-receptor tyrosine kinase pathways.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Proliferation; Cells, Cultured; Drug Interactions; Drug Synergism; Drug Therapy, Combination; Endothelium, Vascular; ErbB Receptors; Esophageal Neoplasms; Flow Cytometry; Humans; Indoles; Phosphorylation; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrroles; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Stomach Neoplasms; Sunitinib; Umbilical Veins; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2; Vascular Endothelial Growth Factor Receptor-3 | 2010 |
A receptor-independent, cell-based JAK activation assay for screening for JAK3-specific inhibitors.
Topics: Binding Sites; Butadienes; Cell Line; Dose-Response Relationship, Drug; Enzyme Activation; ETS Translocation Variant 6 Protein; Genes, Reporter; High-Throughput Screening Assays; Humans; Immunosuppressive Agents; Janus Kinase 2; Janus Kinase 3; MAP Kinase Kinase Kinases; Nitriles; Phosphorylation; Piperidines; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-ets; Pyrimidines; Pyrroles; Recombinant Fusion Proteins; Repressor Proteins; Reproducibility of Results; Response Elements; STAT5 Transcription Factor; Transfection; Tyrphostins | 2010 |
Discovery of 4-amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides as selective, orally active inhibitors of protein kinase B (Akt).
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Half-Life; Humans; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Mice; Mice, Nude; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrimidines; Pyrroles; Structure-Activity Relationship; Xenograft Model Antitumor Assays | 2010 |
Preclinical pharmacokinetics and in vitro metabolism of BMS-690514, a potent inhibitor of EGFR and VEGFR2.
Topics: Algorithms; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood Proteins; Brain Chemistry; Caco-2 Cells; Cell Membrane Permeability; Chromatography, High Pressure Liquid; Computer Simulation; Dogs; ErbB Receptors; Excipients; Hepatocytes; Humans; In Vitro Techniques; Macaca fascicularis; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Microsomes, Liver; Permeability; Piperidines; Protein Binding; Pyrroles; Rats; Rats, Sprague-Dawley; Spectrophotometry, Ultraviolet; Tandem Mass Spectrometry; Triazines; Vascular Endothelial Growth Factor Receptor-2 | 2010 |
Sequential treatment with flavopiridol synergistically enhances pyrrolo-1,5-benzoxazepine-induced apoptosis in human chronic myeloid leukaemia cells including those resistant to imatinib treatment.
Topics: Antineoplastic Agents; Apoptosis; Benzamides; Down-Regulation; Drug Resistance, Neoplasm; Drug Synergism; Flavonoids; Humans; Imatinib Mesylate; Inhibitor of Apoptosis Proteins; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Microtubule-Associated Proteins; Oxazepines; Piperazines; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Survivin | 2010 |
Synthesis and evaluation of the antiproliferative activity of novel pyrrolo[1,2-a]quinoxaline derivatives, potential inhibitors of Akt kinase. Part II.
Topics: Benzimidazoles; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Drug Design; Esters; Female; Humans; Leukemia; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrroles; Quinoxalines | 2010 |
Effect of tyrosine kinase inhibitor treatment of renal cell carcinoma on the accumulation of carbonic anhydrase IX-specific chimeric monoclonal antibody cG250.
Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents; Benzenesulfonates; Carbonic Anhydrases; Carcinoma, Renal Cell; Drug Synergism; Female; Humans; Immunohistochemistry; Indoles; Kidney Neoplasms; Mice; Neoplasm Transplantation; Niacinamide; Phenylurea Compounds; Piperidines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyridines; Pyrroles; Quinazolines; Sorafenib; Sunitinib | 2011 |
Kinase inhibitors attract attention as oral rheumatoid arthritis drugs.
Topics: Administration, Oral; Aminopyridines; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Delivery Systems; Drug Design; Humans; Morpholines; Oxazines; Piperidines; Protein Kinase Inhibitors; Pyridines; Pyrimidines; Pyrroles | 2010 |
Metabolism and disposition of [14C]BMS-690514 after oral administration to rats, rabbits, and dogs.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Bile; Biotransformation; Carbon Radioisotopes; Dogs; Female; Male; Metabolic Networks and Pathways; Piperidines; Pyrroles; Rabbits; Rats; Rats, Sprague-Dawley; Tissue Distribution; Triazines | 2010 |
Structural and thermodynamic characterization of the TYK2 and JAK3 kinase domains in complex with CP-690550 and CMP-6.
Topics: Benzimidazoles; Binding Sites; Calorimetry; Enzyme Inhibitors; Humans; Janus Kinase 3; Kinetics; Models, Molecular; Piperidines; Protein Binding; Protein Structure, Tertiary; Pyridones; Pyrimidines; Pyrroles; TYK2 Kinase | 2010 |
p-Hydroxyamphetamine causes prepulse inhibition disruptions in mice: contribution of dopamine neurotransmission.
Topics: Animals; Benzazepines; Clozapine; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Haloperidol; Indoles; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Oxidopamine; p-Hydroxyamphetamine; Piperazines; Piperidines; Pyridines; Pyrroles; Reflex, Startle; Salicylamides; Sensory Gating; Sympathomimetics; Synaptic Transmission | 2010 |
Rational design of a novel peripherally-restricted, orally active CB(1) cannabinoid antagonist containing a 2,3-diarylpyrrole motif.
Topics: Administration, Oral; Animals; Brain; Drug Design; Gastrointestinal Transit; Piperidines; Pyrazoles; Pyrroles; Rats; Receptor, Cannabinoid, CB1; Rimonabant | 2010 |
BMS-690514, a VEGFR and EGFR tyrosine kinase inhibitor, shows anti-tumoural activity on non-small-cell lung cancer xenografts and induces sequence-dependent synergistic effect with radiation.
Topics: Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Division; Cell Line, Tumor; Cell Survival; Combined Modality Therapy; Drug Screening Assays, Antitumor; ErbB Receptors; Exons; Humans; Mice; Mice, Nude; Mutation; Neoplasm Transplantation; Piperidines; Pyrroles; Receptors, Vascular Endothelial Growth Factor; Sequence Deletion; Transplantation, Heterologous; Triazines | 2010 |
Discovery of drug mode of action and drug repositioning from transcriptional responses.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Algorithms; Antineoplastic Agents; Autophagy; Blotting, Western; Camptothecin; Cell Line, Tumor; Doxorubicin; Drug Discovery; Drug Screening Assays, Antitumor; Flavonoids; Fuzzy Logic; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Irinotecan; Neoplasms; Oligonucleotide Array Sequence Analysis; Phosphorylation; Piperidines; Pyrazoles; Pyrroles; RNA Polymerase II | 2010 |
CP-690550, a Janus kinase inhibitor, suppresses CD4+ T-cell-mediated acute graft-versus-host disease by inhibiting the interferon-γ pathway.
Topics: Animals; Bone Marrow Cells; CD4-Positive T-Lymphocytes; Cell Differentiation; Cytokines; Dendritic Cells; Graft vs Host Disease; Interferon-gamma; Interleukin-2; Janus Kinase 3; Lymphocyte Activation; Lymphocyte Depletion; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Phosphorylation; Piperidines; Pyrimidines; Pyrroles; STAT3 Transcription Factor | 2010 |
Inhibition of MCL-1 in breast cancer cells promotes cell death in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Blotting, Western; Breast Neoplasms; Cell Death; Cell Line, Tumor; Cyclin-Dependent Kinases; Drug Synergism; Electrophoresis, Polyacrylamide Gel; ErbB Receptors; Female; Flavonoids; Fluorescent Antibody Technique; Gene Knockout Techniques; Humans; Indoles; Lapatinib; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Molecular Targeted Therapy; Myeloid Cell Leukemia Sequence 1 Protein; Piperidines; Proto-Oncogene Proteins c-bcl-2; Purines; Pyrroles; Quinazolines; Roscovitine | 2010 |
Therapeutic effect of IL-12/23 and their signaling pathway blockade on brain ischemia model.
Topics: Animals; Antibodies, Monoclonal; Brain Ischemia; Disease Models, Animal; Humans; Immunologic Memory; Interleukin-12; Interleukin-17; Interleukin-23; Janus Kinase 3; Male; Mice; Mice, Inbred C57BL; Piperidines; Pyrimidines; Pyrroles; T-Lymphocytes | 2010 |
Mechanistic studies on a P450-mediated rearrangement of BMS-690514: conversion of a pyrrolotriazine to a hydroxypyridotriazine.
Topics: Antineoplastic Agents; Cytochrome P-450 Enzyme System; Humans; Hydroxylation; Magnetic Resonance Spectroscopy; Mass Spectrometry; Microsomes, Liver; Oxidation-Reduction; Piperidines; Pyrroles; Triazines | 2011 |
Discovery of CP-690,550: a potent and selective Janus kinase (JAK) inhibitor for the treatment of autoimmune diseases and organ transplant rejection.
Topics: Animals; Autoimmune Diseases; Blood Proteins; Caco-2 Cells; Cell Line, Tumor; Cell Membrane Permeability; Cell Proliferation; Cyclohexane Monoterpenes; Dogs; Female; Fibroblasts; Graft Rejection; Humans; In Vitro Techniques; Janus Kinases; Lymphocyte Activation; Macaca fascicularis; Male; Models, Molecular; Monoterpenes; Piperidines; Protein Binding; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Stereoisomerism; Structure-Activity Relationship; T-Lymphocytes; Tissue Distribution | 2010 |
CP-690,550, a therapeutic agent, inhibits cytokine-mediated Jak3 activation and proliferation of T cells from patients with ATL and HAM/TSP.
Topics: Adult; Animals; Cell Line, Tumor; Cell Proliferation; Cytokines; Enzyme Activation; Humans; In Vitro Techniques; Interleukin-15; Janus Kinase 3; Leukemia-Lymphoma, Adult T-Cell; Leukemia, Experimental; Mice; Mice, Inbred NOD; Mice, SCID; Mice, Transgenic; Paraparesis, Tropical Spastic; Phosphorylation; Piperidines; Pyrimidines; Pyrroles; Signal Transduction; STAT5 Transcription Factor; T-Lymphocytes | 2011 |
Identification of a potent Janus kinase 3 inhibitor with high selectivity within the Janus kinase family.
Topics: Cell Line; Cell Membrane Permeability; Crystallography, X-Ray; Humans; Immunosuppressive Agents; Indoles; Janus Kinase 1; Janus Kinase 3; Maleimides; Models, Molecular; Molecular Structure; Phosphorylation; Piperidines; Pyrimidines; Pyrroles; STAT5 Transcription Factor; Structure-Activity Relationship | 2011 |
Preclinical pharmacokinetics and metabolism of MNP001, a piperidine analog of 3-carbamyl compounds.
Topics: Animals; Drug Evaluation, Preclinical; Humans; Male; Microsomes, Liver; Piperidines; Pyrroles; Rats; Rats, Sprague-Dawley | 2011 |
Comparative pre-clinical evaluation of receptor tyrosine kinase inhibitors for the treatment of multiple myeloma.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Evaluation, Preclinical; Humans; Indoles; Mice; Mice, Inbred BALB C; Mice, Nude; Multiple Myeloma; Phthalazines; Piperidines; Protein Kinase Inhibitors; Pyridines; Pyrimidines; Pyrroles; Quinazolines; Receptor Protein-Tyrosine Kinases; Sunitinib; Xenograft Model Antitumor Assays | 2011 |
Antibacterial activities of imidazolium, pyrrolidinium and piperidinium salts.
Topics: Anti-Bacterial Agents; Imidazoles; Microbial Sensitivity Tests; Piperidines; Pyrroles | 2011 |
Effects of targeting the VEGF and PDGF pathways in diffuse orthotopic glioma models.
Topics: Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Blood-Brain Barrier; Brain Neoplasms; Glioma; Humans; Indoles; Magnetic Resonance Imaging; Mice; Mice, Nude; Neovascularization, Pathologic; Piperidines; Pyrroles; Quinazolines; Receptor, Platelet-Derived Growth Factor beta; Signal Transduction; Sunitinib; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays | 2011 |
Modulation of innate and adaptive immune responses by tofacitinib (CP-690,550).
Topics: Adaptive Immunity; Animals; Arthritis, Experimental; Avian Proteins; Cells, Cultured; Chickens; Collagen Type II; Humans; Immunity, Innate; Janus Kinase 3; MAP Kinase Signaling System; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Knockout; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles | 2011 |
The effects of four different tyrosine kinase inhibitors on medullary and papillary thyroid cancer cells.
Topics: Anilides; Axitinib; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Humans; Imidazoles; Indazoles; Indoles; Phosphorylation; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-ret; Pyridines; Pyrroles; Quinazolines; Receptor Protein-Tyrosine Kinases; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Sunitinib; Thyroid Gland; Tumor Cells, Cultured | 2011 |
Estimating transformations for repeated measures modeling of continuous bounded outcome data.
Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Computer Simulation; Data Interpretation, Statistical; Humans; Janus Kinase 3; Models, Statistical; Piperidines; Pyrimidines; Pyrroles; Quality of Life; Surveys and Questionnaires; Treatment Outcome | 2011 |
New acrylamide and oxazolidin derivatives from a termite-associated Streptomyces sp.
Topics: Acrylamides; Animals; Anti-Bacterial Agents; Antineoplastic Agents; Drug Screening Assays, Antitumor; Fermentation; Isoptera; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Oxazoles; Piperidines; Pyrroles; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Streptomyces | 2011 |
Antitumor and antiangiogenic activities of BMS-690514, an inhibitor of human EGF and VEGF receptor kinase families.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Apoptosis; Cell Line; Cell Proliferation; Endothelial Cells; ErbB Receptors; Female; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms; Neovascularization, Pathologic; Piperidines; Pyrroles; Receptor, ErbB-2; Receptors, Vascular Endothelial Growth Factor; Regional Blood Flow; Signal Transduction; Triazines; Xenograft Model Antitumor Assays | 2011 |
CP690,550 inhibits oncostatin M-induced JAK/STAT signaling pathway in rheumatoid synoviocytes.
Topics: Antineoplastic Agents; Arthritis, Rheumatoid; Benzimidazoles; Cells, Cultured; Culture Media, Conditioned; Drug Interactions; Fibroblasts; Humans; Interleukin-6; Janus Kinase 1; Janus Kinase 2; Janus Kinase 3; Oncostatin M; p38 Mitogen-Activated Protein Kinases; Piperidines; Pyridones; Pyrimidines; Pyrroles; RNA, Messenger; Signal Transduction; STAT1 Transcription Factor; STAT3 Transcription Factor; STAT5 Transcription Factor; Synovial Membrane | 2011 |
[New therapeutic options for advanced thyroid cancer].
Topics: Antineoplastic Agents; Benzenesulfonates; Humans; Indoles; Niacinamide; Phenylurea Compounds; Piperidines; Pyridines; Pyrroles; Quinazolines; Sorafenib; Sunitinib; Thyroid Neoplasms | 2011 |
Pfizer's JAK inhibitor sails through phase 3 in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Clinical Trials, Phase III as Topic; Drug Delivery Systems; Drug Industry; Humans; Immunosuppression Therapy; Janus Kinases; Piperidines; Pyrimidines; Pyrroles; Receptors, Cytokine; Signal Transduction | 2011 |
[KIT and KIT: from biology to clinical use].
Topics: Antineoplastic Agents; Benzamides; Benzenesulfonates; Gastrointestinal Stromal Tumors; Humans; Imatinib Mesylate; Indoles; Niacinamide; Phenylurea Compounds; Piperazines; Piperidines; Prognosis; Protein Kinase Inhibitors; Proto-Oncogene Mas; Proto-Oncogene Proteins c-kit; Pyridines; Pyrimidines; Pyrroles; Sorafenib; Sunitinib; Thiazoles | 2012 |
In vitro characterization of the metabolic pathways and cytochrome P450 inhibition and induction potential of BMS-690514, an ErbB/vascular endothelial growth factor receptor inhibitor.
Topics: Cells, Cultured; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; ErbB Receptors; Glucuronosyltransferase; Hepatocytes; Humans; Microsomes, Liver; NADP; Piperidines; Pyrroles; Receptors, Vascular Endothelial Growth Factor; Triazines; Uridine Diphosphate Glucuronic Acid | 2011 |
A case study of model-based Bayesian dose response estimation.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Bayes Theorem; Chronic Disease; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Dose-Response Relationship, Drug; Humans; Longitudinal Studies; Nonlinear Dynamics; Piperidines; Pyrimidines; Pyrroles | 2011 |
Endocannabinoid signal in the gut controls dietary fat intake.
Topics: Amidohydrolases; Animals; Benzyl Compounds; Brain; Cannabinoid Receptor Modulators; Dietary Fats; Eating; Endocannabinoids; Gastrointestinal Tract; Intestine, Small; Lipids; Male; Phospholipase D; Piperidines; Pyrazoles; Pyrroles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Signal Transduction; Vagotomy | 2011 |
Influence of Janus kinase inhibition on interleukin 6-mediated induction of acute-phase serum amyloid A in rheumatoid synovium.
Topics: Acute-Phase Reaction; Arthritis, Rheumatoid; Cells, Cultured; Enzyme Inhibitors; Humans; Interleukin-6; Janus Kinase 2; Janus Kinase 3; Janus Kinases; Piperidines; Pyrimidines; Pyrroles; RNA, Messenger; Serum Amyloid A Protein; Signal Transduction; STAT3 Transcription Factor; Synovial Membrane | 2011 |
Inhibitory effects of the JAK inhibitor CP690,550 on human CD4(+) T lymphocyte cytokine production.
Topics: Antibodies, Monoclonal; Arthritis, Rheumatoid; CD3 Complex; CD4-Positive T-Lymphocytes; Cells, Cultured; Cytokines; Humans; Immunosuppression Therapy; Janus Kinase 3; Lymphocyte Activation; Phosphorylation; Piperidines; Pyrimidines; Pyrroles; Receptors, Antigen, T-Cell; Signal Transduction; STAT Transcription Factors | 2011 |
IL-1β and TNFα-initiated IL-6-STAT3 pathway is critical in mediating inflammatory cytokines and RANKL expression in inflammatory arthritis.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Chronic Disease; Enzyme Inhibitors; Fibroblasts; Gene Expression; Humans; Inflammation; Interleukin-1beta; Interleukin-6; Joints; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Osteoclasts; Piperidines; Pyrimidines; Pyrroles; RANK Ligand; Signal Transduction; STAT3 Transcription Factor; Tumor Necrosis Factor-alpha | 2011 |
Selective blockade of dopamine D3 receptors enhances while D2 receptor antagonism impairs social novelty discrimination and novel object recognition in rats: a key role for the prefrontal cortex.
Topics: Animals; Benzopyrans; Discrimination, Psychological; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Indoles; Male; Mice; Mice, Knockout; Microinjections; Piperidines; Prefrontal Cortex; Pyrroles; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, Dopamine D3; Recognition, Psychology | 2012 |
The JAK inhibitor CP-690,550 (tofacitinib) inhibits TNF-induced chemokine expression in fibroblast-like synoviocytes: autocrine role of type I interferon.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Autocrine Communication; Cells, Cultured; Chemokines; Drug Evaluation, Preclinical; Fibroblasts; Humans; Interferon Type I; Interleukin-6; Janus Kinase 3; Mice; Phosphorylation; Piperidines; Pyrimidines; Pyrroles; STAT1 Transcription Factor; STAT3 Transcription Factor; Synovial Membrane; Tumor Necrosis Factor-alpha | 2012 |
The JAK inhibitor tofacitinib regulates synovitis through inhibition of interferon-γ and interleukin-17 production by human CD4+ T cells.
Topics: Animals; Cartilage, Articular; CD4-Positive T-Lymphocytes; Cell Proliferation; Humans; Interferon-gamma; Interleukin-17; Janus Kinase 3; Mice; Monocytes; Piperidines; Pyrimidines; Pyrroles; Synovial Membrane; Synovitis | 2012 |
Trifluoromethylation of arenes and heteroarenes by means of photoredox catalysis.
Topics: Anticholesteremic Agents; Atorvastatin; Catalysis; Chemistry Techniques, Synthetic; Cholinesterase Inhibitors; Donepezil; Drug Design; Flavones; Halogenation; Heptanoic Acids; Indans; Isomerism; Light; Methylation; Molecular Structure; Oxidation-Reduction; Pharmaceutical Preparations; Photochemical Processes; Piperidines; Pyrroles; Uracil | 2011 |
Influence of atorvastatin on the pharmacodynamic and pharmacokinetic activity of repaglinide in rats and rabbits.
Topics: Animals; Atorvastatin; Blood Glucose; Carbamates; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Diabetes Mellitus, Experimental; Drug Interactions; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Piperidines; Pyrroles; Rabbits; Rats | 2012 |
Profiling of dihydroorotate dehydrogenase, p38 and JAK inhibitors in the rat adjuvant-induced arthritis model: a translational study.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Benzamides; Bridged Bicyclo Compounds, Heterocyclic; Crotonates; Dihydroorotate Dehydrogenase; Dose-Response Relationship, Drug; Edema; Enzyme Inhibitors; Gastrointestinal Tract; Half-Life; Hydroxybutyrates; Hypercholesterolemia; Immunosuppressive Agents; Janus Kinases; Joints; Leukocyte Disorders; Male; Nitriles; Oxidoreductases Acting on CH-CH Group Donors; p38 Mitogen-Activated Protein Kinases; Piperidines; Pyrimidines; Pyrroles; Rats; Rats, Wistar; Splenomegaly; Toluidines; Weight Loss | 2012 |
Low dose CP-690,550 (tofacitinib), a pan-JAK inhibitor, accelerates the onset of experimental autoimmune encephalomyelitis by potentiating Th17 differentiation.
Topics: Animals; Cell Differentiation; Encephalomyelitis, Autoimmune, Experimental; HEK293 Cells; Humans; Janus Kinase 3; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Phosphorylation; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Smad2 Protein; STAT1 Transcription Factor; STAT3 Transcription Factor; STAT5 Transcription Factor; Th1 Cells; Th17 Cells; Th2 Cells | 2012 |
Pericyte depletion results in hypoxia-associated epithelial-to-mesenchymal transition and metastasis mediated by met signaling pathway.
Topics: Animals; Antineoplastic Agents; Benzamides; Benzenesulfonates; Breast Neoplasms; Cell Hypoxia; Cell Line, Tumor; Crizotinib; Epithelial-Mesenchymal Transition; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Imatinib Mesylate; Indoles; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Neoplasm Metastasis; Niacinamide; Pericytes; Phenylurea Compounds; Piperazines; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-met; Pyrazoles; Pyridines; Pyrimidines; Pyrroles; Signal Transduction; Sorafenib; Sunitinib; Tumor Cells, Cultured | 2012 |
EGCG enhances the therapeutic potential of gemcitabine and CP690550 by inhibiting STAT3 signaling pathway in human pancreatic cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Catechin; Cell Line, Tumor; Cell Movement; Cell Survival; Deoxycytidine; Drug Synergism; Gemcitabine; Humans; Pancreatic Neoplasms; Piperidines; Pyrimidines; Pyrroles; Signal Transduction; STAT3 Transcription Factor | 2012 |
Pyrrolovesamicols--synthesis, structure and VAChT binding of two 4-fluorobenzoyl regioisomers.
Topics: Animals; Binding Sites; Binding, Competitive; Cell Line; Chromatography, High Pressure Liquid; Contrast Media; Crystallography, X-Ray; Epoxy Compounds; Fluorine Radioisotopes; Humans; Ligands; Molecular Structure; Piperidines; Positron-Emission Tomography; Pyrroles; Rats; Stereoisomerism; Tritium; Vesicular Acetylcholine Transport Proteins | 2012 |
Novel inhibitors of neurotropic alphavirus replication that improve host survival in a mouse model of acute viral encephalitis.
Topics: Acute Disease; Alphavirus; Alphavirus Infections; Animals; Antiviral Agents; Brain; Cell Survival; Encephalitis, Viral; Indoles; Membranes, Artificial; Mice; Microsomes, Liver; Neurons; Permeability; Piperidines; Pyrroles; Replicon; Spinal Cord; Stereoisomerism; Structure-Activity Relationship; Thiophenes; Viral Tropism; Virus Replication | 2012 |
Risk of tuberculosis reactivation with tofacitinib (CP-690550).
Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Immunologic Factors; Mice; Mice, Inbred BALB C; Mycobacterium tuberculosis; Piperidines; Pyrimidines; Pyrroles; Tuberculosis | 2012 |
[Anti-rheumatic effect of JAK-inhibitors].
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Humans; Janus Kinases; Mice; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles | 2012 |
CDK inhibitors upregulate BH3-only proteins to sensitize human myeloma cells to BH3 mimetic therapies.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; bcl-X Protein; Biomimetic Materials; Cell Line, Tumor; Cyclin-Dependent Kinases; Drug Synergism; Flavonoids; Humans; Indoles; Membrane Proteins; Mice; Mice, Inbred NOD; Mice, Nude; Mice, SCID; Mitochondria; Multiple Myeloma; Myeloid Cell Leukemia Sequence 1 Protein; Peptide Fragments; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Up-Regulation; Xenograft Model Antitumor Assays | 2012 |
Janus kinase 3-activating mutations identified in natural killer/T-cell lymphoma.
Topics: Adult; Aged; Aged, 80 and over; Animals; Blotting, Western; Cell Line, Tumor; Cell Proliferation; DNA Mutational Analysis; Enzyme Activation; Female; Humans; Janus Kinase 3; Lymphoma, T-Cell; Male; Middle Aged; Mutation; Natural Killer T-Cells; Phosphorylation; Piperidines; Pyrimidines; Pyrroles; RNA Interference; STAT5 Transcription Factor | 2012 |
Unusual short-term complete response to two regimens of cytotoxic chemotherapy in a patient with poorly differentiated thyroid carcinoma.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Benzenesulfonates; Cisplatin; Combined Modality Therapy; Doxorubicin; Fatal Outcome; Female; Fluorodeoxyglucose F18; Humans; Indoles; Iodine Radioisotopes; Lung Neoplasms; Middle Aged; Niacinamide; Paclitaxel; Phenylurea Compounds; Piperidines; Pyridines; Pyrroles; Quinazolines; Radiopharmaceuticals; Sorafenib; Sunitinib; Thyroid Neoplasms; Thyroidectomy; Tomography, X-Ray Computed | 2012 |
A novel strategy for the synthesis of 3-(N-heteryl)pyrrole derivatives.
Topics: Catalysis; Hydrogenation; Molecular Structure; Piperidines; Pyridinium Compounds; Pyrroles | 2012 |
[Janus kinase inhibitors].
Topics: Antirheumatic Agents; Drug Delivery Systems; Humans; Janus Kinases; Piperidines; Pyrimidines; Pyrroles; Rheumatic Diseases | 2012 |
Lab reports and cat scans: can veterinary oncology guide our way to new treatments for human cancers?
Topics: Animals; Antineoplastic Agents; Benzamides; Breast Neoplasms; Cats; Disease Models, Animal; Dogs; Female; Humans; Imatinib Mesylate; Indoles; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mast-Cell Sarcoma; Neoplasms; Piperazines; Piperidines; Protein Kinase Inhibitors; Pyridines; Pyrimidines; Pyrroles; Thiazoles; Transcriptome | 2012 |
Kinase inhibition--a new approach to the treatment of rheumatoid arthritis.
Topics: Adalimumab; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Enzyme Inhibitors; Female; Humans; Janus Kinase 3; Male; Piperidines; Pyrimidines; Pyrroles | 2012 |
JAK inhibition with tofacitinib suppresses arthritic joint structural damage through decreased RANKL production.
Topics: Animals; Arthritis, Experimental; Bone Resorption; Cell Differentiation; Cells, Cultured; Disease Models, Animal; Female; Humans; Janus Kinases; Macrophages; Monocytes; Osteoclasts; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; RANK Ligand; Rats; Rats, Inbred Lew; Signal Transduction; T-Lymphocytes | 2012 |
Tofacitinib for the treatment of moderate to severe rheumatoid arthritis.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Interactions; Humans; Janus Kinase 3; Piperidines; Pyrimidines; Pyrroles; Severity of Illness Index | 2012 |
Regulation of inflammatory responses in tumor necrosis factor-activated and rheumatoid arthritis synovial macrophages by JAK inhibitors.
Topics: Animals; Arthritis, Rheumatoid; Cells, Cultured; Disease Models, Animal; Enzyme Inhibitors; Humans; In Vitro Techniques; Inflammation; Interleukin-6; Janus Kinases; Macrophages; Mice; Mice, Inbred C57BL; NF-kappa B; NFATC Transcription Factors; Nitriles; Piperidines; Proto-Oncogene Proteins c-jun; Pyrazoles; Pyrimidines; Pyrroles; Signal Transduction; STAT1 Transcription Factor; Synovial Membrane; Tumor Necrosis Factor-alpha | 2012 |
In-vitro growth inhibition of chemotherapy and molecular targeted agents in hepatocellular carcinoma.
Topics: Alanine; alpha-Fetoproteins; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Benzimidazoles; Carcinoma, Hepatocellular; Cetuximab; Dasatinib; Doxorubicin; Drug Screening Assays, Antitumor; Epothilones; Gefitinib; Humans; Indoles; Inhibitory Concentration 50; Liver Neoplasms; Niacinamide; Phenylurea Compounds; Piperidines; Pyridones; Pyrimidines; Pyrroles; Quinazolines; Sorafenib; Sunitinib; Thiazoles; Triazines | 2013 |
Discovery of 6,7-dihydro-5H-pyrrolo[2,3-a]pyrimidines as orally available G protein-coupled receptor 119 agonists.
Topics: Administration, Oral; Animals; Cell Line; Colon; Glucagon-Like Peptide 1; Glucose; Glucose Tolerance Test; Humans; Hypoglycemic Agents; Incretins; Intestinal Mucosa; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Piperidines; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, G-Protein-Coupled; Stereoisomerism; Structure-Activity Relationship | 2012 |
FDA approves tofacitinib for rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Approval; Humans; Piperidines; Pyrimidines; Pyrroles; United States; United States Food and Drug Administration | 2012 |
Therapeutics: Silencing psoriasis.
Topics: Alefacept; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Clinical Trials as Topic; Dermatologic Agents; Humans; Interleukin-17; Piperidines; Psoriasis; Pyrimidines; Pyrroles; Recombinant Fusion Proteins; Thalidomide; Ustekinumab | 2012 |
Tofacitinib, a janus kinase inhibitor demonstrates efficacy in an IL-15 transgenic mouse model that recapitulates pathologic manifestations of celiac disease.
Topics: Animals; Celiac Disease; Disease Models, Animal; Female; Humans; Immunophenotyping; Interleukin-15; Intestine, Small; Janus Kinases; Killer Cells, Natural; Lymphocyte Subsets; Mice; Mice, Transgenic; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Spleen; Time Factors | 2013 |
Comparison of the effect of standard and novel immunosuppressive drugs on CMV-specific T-cell cytokine profiling.
Topics: Abatacept; Adult; Cytokines; Cytomegalovirus; Cytomegalovirus Infections; Dose-Response Relationship, Drug; Humans; Immunoconjugates; Immunosuppressive Agents; In Vitro Techniques; Middle Aged; Mycophenolic Acid; Piperidines; Pyrimidines; Pyrroles; Sirolimus; T-Lymphocytes; Tacrolimus; Th1 Cells; Th2 Cells; Transcriptome | 2013 |
Kinase inhibition in rheumatoid arthritis: a big advance?
Topics: Arthritis, Rheumatoid; Female; Humans; Janus Kinases; Male; Methotrexate; Piperidines; Pyrimidines; Pyrroles; Tumor Necrosis Factor-alpha | 2013 |
Pfizer's first-in-class JAK inhibitor pricey for rheumatoid arthritis market.
Topics: Arthritis, Rheumatoid; Drug Costs; Drug Industry; Humans; Janus Kinases; National Institutes of Health (U.S.); Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; United States | 2013 |
RA gets first oral agent to compete with biologics.
Topics: Administration, Oral; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Clinical Trials, Phase III as Topic; Drug Approval; Female; Humans; Male; Middle Aged; Piperidines; Pyrimidines; Pyrroles; Therapeutic Equivalency; United States; United States Food and Drug Administration | 2013 |
Chemical probes of a trisubstituted pyrrole to identify its protein target(s) in Plasmodium sporozoites.
Topics: Animals; Hepatocytes; Nitrogen; Piperidines; Plasmodium; Protozoan Proteins; Pyrroles; Sporozoites | 2013 |
Inhibitory effect of ketoconazole on the pharmacokinetics of a multireceptor tyrosine kinase inhibitor BMS-690514 in healthy participants: assessing the mechanism of the interaction with physiologically-based pharmacokinetic simulations.
Topics: Adult; Antifungal Agents; Antineoplastic Agents; Area Under Curve; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B, Member 1; Computer Simulation; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Genotype; Humans; Ketoconazole; Male; Middle Aged; Models, Biological; Piperidines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrroles; Triazines; Young Adult | 2013 |
TYK2-STAT1-BCL2 pathway dependence in T-cell acute lymphoblastic leukemia.
Topics: Animals; Antineoplastic Agents; Bone Marrow Cells; Cell Line; Cell Survival; Cells, Cultured; Humans; Interleukin-10; Janus Kinase 3; Leukocytes, Mononuclear; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Piperidines; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Pyrimidines; Pyrroles; RNA Interference; Signal Transduction; STAT1 Transcription Factor; TYK2 Kinase; Tyrphostins | 2013 |
Effects of the Janus kinase inhibitor CP-690550 (tofacitinib) in a rat model of oxazolone-induced chronic dermatitis.
Topics: Animals; Anti-Inflammatory Agents; Cytokines; Dermatitis, Allergic Contact; Ear; Female; Hyperplasia; Janus Kinases; Oxazolone; Piperidines; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Skin | 2013 |
Simultaneous analysis of anticancer agents bortezomib, imatinib, nilotinib, dasatinib, erlotinib, lapatinib, sorafenib, sunitinib and vandetanib in human plasma using LC/MS/MS.
Topics: Antineoplastic Agents; Benzamides; Boronic Acids; Bortezomib; Chromatography, Liquid; Dasatinib; Erlotinib Hydrochloride; Humans; Imatinib Mesylate; Indoles; Lapatinib; Niacinamide; Phenylurea Compounds; Piperazines; Piperidines; Pyrazines; Pyrimidines; Pyrroles; Quinazolines; Reproducibility of Results; Sorafenib; Sunitinib; Tandem Mass Spectrometry; Thiazoles | 2013 |
A facile chemo-, regio- and stereoselective synthesis and cholinesterase inhibitory activity of spirooxindole-pyrrolizine-piperidine hybrids.
Topics: Butyrylcholinesterase; Cholinesterase Inhibitors; Cholinesterases; Cyclization; Dose-Response Relationship, Drug; Indoles; Models, Molecular; Molecular Structure; Oxindoles; Piperidines; Pyrroles; Spiro Compounds; Stereoisomerism; Structure-Activity Relationship | 2013 |
Tofacitinib and other kinase inhibitors in the treatment of psoriasis.
Topics: Humans; Piperidines; Protein Kinase Inhibitors; Psoriasis; Pyrimidines; Pyrroles | 2013 |
Selective JAK/STAT3 signalling regulates transcription of colony stimulating factor-2 and -3 in Concanavalin-A-activated mesenchymal stromal cells.
Topics: Cell Movement; Cell Proliferation; Cells, Cultured; Concanavalin A; Enzyme Inhibitors; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Janus Kinases; Macrophage Colony-Stimulating Factor; Matrix Metalloproteinase 1; Mesenchymal Stem Cells; Neovascularization, Physiologic; Phosphorylation; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; RNA Interference; RNA, Small Interfering; Signal Transduction; STAT3 Transcription Factor; Toll-Like Receptor 2; Toll-Like Receptor 6; Transcription, Genetic; TYK2 Kinase; Tyrphostins | 2013 |
JAK3 deregulation by activating mutations confers invasive growth advantage in extranodal nasal-type natural killer cell lymphoma.
Topics: Adult; Aged; Aged, 80 and over; Animals; Case-Control Studies; Cell Line, Tumor; Cell Proliferation; Cell Survival; Disease Models, Animal; Female; Gene Expression Regulation, Neoplastic; Humans; Janus Kinase 3; Lymphoma, Extranodal NK-T-Cell; Male; Mice; Middle Aged; Mutation; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Staging; Phosphorylation; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Tumor Burden; Xenograft Model Antitumor Assays | 2014 |
An atom economic synthesis and AChE inhibitory activity of novel dispiro 7-aryltetrahydro-1H-pyrrolo[1,2-c][1,3]thiazole and 4-aryloctahydroindolizine N-methylpiperidin-4-one hybrid heterocycles.
Topics: Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Electrophorus; Models, Molecular; Molecular Structure; Piperidines; Pyrroles; Structure-Activity Relationship; Thiazoles | 2013 |
Differential effect of orexin-1 and CRF-1 antagonism on stress circuits: a fMRI study in the rat with the pharmacological stressor Yohimbine.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Aminopyridines; Amygdala; Animals; Benzazepines; Corpus Striatum; Corticosterone; Dopamine Antagonists; Functional Neuroimaging; Gyrus Cinguli; Male; Medetomidine; Neural Pathways; Orexin Receptor Antagonists; Piperidines; Pyrimidines; Pyrroles; Rats; Receptors, Corticotropin-Releasing Hormone; Stress, Psychological; Yohimbine | 2013 |
Structural equilibrium in new nitroxide-capped cyclodextrins: CW and pulse EPR study.
Topics: Cyclodextrins; Electron Spin Resonance Spectroscopy; Hydrogen-Ion Concentration; Kinetics; Nitrogen Oxides; Piperidines; Pyrroles; Pyrrolidines; Spin Labels | 2013 |
New drugs 2013, part 2.
Topics: Acetanilides; Adrenergic beta-Agonists; Anti-Asthmatic Agents; Anti-Retroviral Agents; Bronchodilator Agents; Citrates; Crotonates; Drug Approval; Humans; Hydroxybutyrates; Immunosuppressive Agents; Laxatives; Nitriles; Organometallic Compounds; Peptides; Picolines; Piperidines; Pyrimidines; Pyrroles; Quinolones; Receptors, Guanylate Cyclase-Coupled; Thiazoles; Toluidines; Tropanes | 2013 |
Report of the second joint meeting of ESOT and AST: current pipelines in biotech and pharma.
Topics: Abatacept; B-Lymphocytes; Calcineurin Inhibitors; Cell- and Tissue-Based Therapy; Delayed Graft Function; Graft Rejection; Histocompatibility Testing; Humans; Immune Tolerance; Immunoconjugates; Immunosuppression Therapy; Janus Kinase 3; Kidney Transplantation; Organ Transplantation; Piperidines; Protein Kinase C; Pyrimidines; Pyrroles; T-Lymphocytes | 2013 |
Systemics to topicals in psoriasis: the unfilled need.
Topics: Dermatologic Agents; Female; Humans; Male; Piperidines; Protein Kinase Inhibitors; Psoriasis; Pyrimidines; Pyrroles | 2013 |
Insulin-dependent diabetes induced by pancreatic beta cell expression of IL-15 and IL-15Rα.
Topics: Animals; Diabetes Mellitus, Type 1; Disease Models, Animal; Humans; Insulin-Secreting Cells; Interleukin-15; Interleukin-15 Receptor alpha Subunit; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Mice, Transgenic; Piperidines; Pyrimidines; Pyrroles; Signal Transduction | 2013 |
Inhibition of Janus kinase/signal transducer and activator of transcription (JAK/STAT) signalling pathway in rheumatoid synovial fibroblasts using small molecule compounds.
Topics: Arthritis, Rheumatoid; Fibroblasts; Humans; Janus Kinases; Oncostatin M; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Signal Transduction; STAT Transcription Factors; Synovial Fluid; Synovial Membrane | 2013 |
The JAK inhibitor, tofacitinib, reduces the T cell stimulatory capacity of human monocyte-derived dendritic cells.
Topics: B7-1 Antigen; B7-2 Antigen; Cell Differentiation; Dendritic Cells; Humans; Interleukin-1beta; Interleukin-6; Janus Kinase 3; Lymphocyte Activation; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; T-Lymphocytes; Tumor Necrosis Factor-alpha | 2014 |
Summaries for patients: tofacitinib for the treatment of rheumatoid arthritis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Janus Kinase 3; Male; Methotrexate; Middle Aged; Piperidines; Pyrimidines; Pyrroles; Remission Induction; Treatment Outcome | 2013 |
Pharmacokinetics of tofacitinib, a janus kinase inhibitor, in patients with impaired renal function and end-stage renal disease.
Topics: Adult; Aged; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Female; Half-Life; Humans; Janus Kinases; Kidney Diseases; Kidney Failure, Chronic; Liver; Male; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Renal Dialysis | 2014 |
Distinct pathways regulated by RET and estrogen receptor in luminal breast cancer demonstrate the biological basis for combination therapy.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Biomarkers, Tumor; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Estrogen Receptor alpha; Female; Flow Cytometry; Humans; Indoles; Mammary Neoplasms, Experimental; MAP Kinase Signaling System; MCF-7 Cells; Mice; Piperidines; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-ret; Pyrroles; Quinazolines; Random Allocation; Signal Transduction; Sunitinib; Tamoxifen; Transcription Factor AP-2 | 2014 |
Dual HER/VEGF receptor targeting inhibits in vivo ovarian cancer tumor growth.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cluster Analysis; Disease Models, Animal; Disease Progression; Female; Humans; Mice; Neoplasm Grading; Ovarian Neoplasms; Piperidines; Protein Kinase Inhibitors; Proteomics; Pyrroles; Quinazolines; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Triazines; Tumor Burden; Xenograft Model Antitumor Assays | 2013 |
Reversal of CD8 T-cell-mediated mucocutaneous graft-versus-host-like disease by the JAK inhibitor tofacitinib.
Topics: Administration, Oral; Animals; Bone Marrow; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Cell Proliferation; Chemokines; Cytokines; Dermatitis; Gene Expression Regulation; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Interleukin-2; Keratinocytes; Mice; Mice, Inbred C57BL; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles | 2014 |
IL-6-mediated induction of matrix metalloproteinase-9 is modulated by JAK-dependent IL-10 expression in macrophages.
Topics: Animals; Cell Line; Cyclooxygenase 2; Dinoprostone; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Hydroxyprostaglandin Dehydrogenases; Interleukin-10; Interleukin-6; Intramolecular Oxidoreductases; Janus Kinases; Macrophages; Matrix Metalloproteinase 9; Mice; Models, Biological; Piperidines; Prostaglandin-E Synthases; Pyrimidines; Pyrroles | 2014 |
Effects of sulfasalazine and tofacitinib on the protein profile of articular chondrocytes.
Topics: Aged; Cartilage, Articular; Chondrocytes; Female; Humans; Interleukin-1beta; Male; Piperidines; Pyrimidines; Pyrroles; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Sulfasalazine | 2014 |
Effects of topical Janus kinase inhibition on ocular surface inflammation and immunity.
Topics: Adaptive Immunity; Administration, Topical; Animals; CD11b Antigen; Cell Movement; Cytokines; Disease Models, Animal; Dry Eye Syndromes; Female; Flow Cytometry; Gene Expression Regulation; Janus Kinase 3; Keratitis; Leukocyte Common Antigens; Leukocytes; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Ophthalmic Solutions; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Real-Time Polymerase Chain Reaction; Receptors, Chemokine | 2014 |
Pharmacological and genomic profiling identifies NF-κB-targeted treatment strategies for mantle cell lymphoma.
Topics: Adenine; Baculoviral IAP Repeat-Containing 3 Protein; Base Sequence; Blotting, Western; CARD Signaling Adaptor Proteins; Cell Line; Cell Survival; DNA Primers; Guanylate Cyclase; Humans; Inhibitor of Apoptosis Proteins; Luminescent Measurements; Lymphoma, Mantle-Cell; Microarray Analysis; Molecular Sequence Data; NF-kappa B; NF-kappaB-Inducing Kinase; Piperidines; Protein Serine-Threonine Kinases; Pyrazoles; Pyrimidines; Pyrroles; Quinazolines; Real-Time Polymerase Chain Reaction; Receptors, Antigen, B-Cell; RNA Interference; Sequence Analysis, RNA; Signal Transduction; TNF Receptor-Associated Factor 2; TNF Receptor-Associated Factor 3; Trypan Blue; Ubiquitin-Protein Ligases | 2014 |
Design and synthesis of tricyclic JAK3 inhibitors with picomolar affinities as novel molecular probes.
Topics: Drug Design; HeLa Cells; Humans; Janus Kinase 3; Models, Molecular; Molecular Probes; Phosphorylation; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Signal Transduction; STAT Transcription Factors | 2014 |
Fate of lymphocytes after withdrawal of tofacitinib treatment.
Topics: Antigens, CD; B-Lymphocytes; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Proliferation; Drug Administration Schedule; Humans; Janus Kinase 3; Killer Cells, Natural; Lymphocyte Activation; Lymphocyte Count; Phytohemagglutinins; Piperidines; Primary Cell Culture; Protein Kinase Inhibitors; Pyrimidines; Pyrroles | 2014 |
Ruxolitinib and tofacitinib are potent and selective inhibitors of HIV-1 replication and virus reactivation in vitro.
Topics: Animals; Cells, Cultured; HIV Infections; HIV-1; Humans; Janus Kinase 1; Janus Kinase 2; Lymphocytes; Macaca mulatta; Macrophages; Nitriles; Piperidines; Pyrazoles; Pyrimidines; Pyrroles; Virus Replication | 2014 |
Tyrosine kinase inhibitor treatments in patients with metastatic thyroid carcinomas: a retrospective study of the TUTHYREF network.
Topics: Adenocarcinoma; Adenocarcinoma, Follicular; Adenoma, Oxyphilic; Adult; Aged; Antineoplastic Agents; Bone Neoplasms; Carcinoma; Carcinoma, Neuroendocrine; Carcinoma, Papillary; Disease-Free Survival; Female; Humans; Indoles; Liver Neoplasms; Lung Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Niacinamide; Phenylurea Compounds; Piperidines; Pleural Neoplasms; Protein-Tyrosine Kinases; Pyrroles; Quinazolines; Retrospective Studies; Sorafenib; Sunitinib; Thyroid Cancer, Papillary; Thyroid Neoplasms; Treatment Outcome | 2014 |
Combination of tumor necrosis factor α and interleukin-6 induces mouse osteoclast-like cells with bone resorption activity both in vitro and in vivo.
Topics: Animals; Bone Resorption; Cell Differentiation; Cells, Cultured; Interleukin-6; Macrophages; Mice; NF-kappa B; NFATC Transcription Factors; Osteoclasts; Osteoprotegerin; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-fos; Pyrimidines; Pyrroles; RANK Ligand; STAT3 Transcription Factor; Tumor Necrosis Factor-alpha | 2014 |
The pharmacokinetics, metabolism, and clearance mechanisms of tofacitinib, a janus kinase inhibitor, in humans.
Topics: Aryl Hydrocarbon Hydroxylases; Biotransformation; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Feces; Female; Humans; Janus Kinases; Liver; Magnetic Resonance Spectroscopy; Male; Metabolic Clearance Rate; Microsomes, Liver; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Tandem Mass Spectrometry | 2014 |
Inhibition of TAK1 and/or JAK can rescue impaired chondrogenic differentiation of human mesenchymal stem cells in osteoarthritis-like conditions.
Topics: Adult; Cartilage, Articular; Cell Differentiation; Chondrogenesis; Fetus; Humans; Janus Kinases; MAP Kinase Kinase Kinases; Mesenchymal Stem Cells; Osteoarthritis; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Time Factors; Zearalenone | 2014 |
In vivo administration of a JAK3 inhibitor during acute SIV infection leads to significant increases in viral load during chronic infection.
Topics: Animals; B-Lymphocytes; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Chronic Disease; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Janus Kinase 3; Killer Cells, Natural; Macaca mulatta; Piperidines; Pyrimidines; Pyrroles; Simian Acquired Immunodeficiency Syndrome; Viral Load | 2014 |
[A new therapeutical option for chronic inflammation in rheumatology: janus kinases inhibitors (JAK)].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Chronic Disease; Drug Approval; Humans; Inflammation; Janus Kinases; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Rheumatic Diseases; Switzerland | 2014 |
72nd annual meeting of the American Academy of Dermatology.
Topics: Antifungal Agents; Attention Deficit Disorder with Hyperactivity; Boron Compounds; Botulinum Toxins, Type A; Bridged Bicyclo Compounds, Heterocyclic; Brimonidine Tartrate; Depression; Dermatitis, Atopic; Food Hypersensitivity; Humans; Immunologic Factors; Ivermectin; Phosphodiesterase Inhibitors; Phototherapy; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Quinoxalines; Skin Diseases; Societies, Medical; Thalidomide; Triazoles; United States | 2014 |
Recent trends in orthopedic surgery aiming to improve quality of life for those with rheumatoid arthritis: data from a large observational cohort.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Chromones; Cohort Studies; Databases, Factual; Female; Humans; Japan; Joints; Male; Orthopedic Procedures; Piperidines; Pyrimidines; Pyrroles; Quality of Life; Sulfonamides; Tacrolimus | 2014 |
PDGFRα up-regulation mediated by sonic hedgehog pathway activation leads to BRAF inhibitor resistance in melanoma cells with BRAF mutation.
Topics: Animals; Antineoplastic Agents; Benzamides; Benzimidazoles; Biphenyl Compounds; Cell Line, Tumor; Drug Resistance, Neoplasm; Extracellular Signal-Regulated MAP Kinases; Gene Silencing; Hedgehog Proteins; Humans; Imatinib Mesylate; Indoles; MAP Kinase Signaling System; Melanoma; Mice; Piperazines; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-akt; Pyridines; Pyrimidines; Pyrroles; Receptor, Platelet-Derived Growth Factor alpha; RNA, Small Interfering; Sulfonamides; Sunitinib; Up-Regulation; Vemurafenib | 2014 |
A unique case of refractory primary mediastinal B-cell lymphoma with JAK3 mutation and the role for targeted therapy.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Doxorubicin; Drug Resistance, Neoplasm; Etoposide; Female; Gene Expression Regulation, Neoplastic; Humans; Janus Kinase 3; Lymphoma, Large B-Cell, Diffuse; Mediastinal Neoplasms; Molecular Targeted Therapy; Mutation; Piperidines; Prednisone; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Signal Transduction; Stem Cell Transplantation; Transplantation, Homologous; Vincristine | 2014 |
Tofacitinib suppresses antibody responses to protein therapeutics in murine hosts.
Topics: ADP Ribose Transferases; Animals; Antibody Formation; B-Lymphocytes; Bacterial Toxins; Exotoxins; Female; Germinal Center; Hemocyanins; Immunoglobulin G; Immunoglobulin M; Immunotoxins; Janus Kinases; Mice; Mice, Inbred BALB C; Piperidines; Protein Kinase Inhibitors; Pseudomonas aeruginosa Exotoxin A; Pyrimidines; Pyrroles; Virulence Factors | 2014 |
GluN2B N-methyl-D-aspartic acid receptor subunit mediates atorvastatin-Induced neuroprotection after focal cerebral ischemia.
Topics: Animals; Anticholesteremic Agents; Atorvastatin; Brain Ischemia; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Embryo, Mammalian; Heptanoic Acids; Male; Maze Learning; Nerve Tissue Proteins; Nervous System Diseases; Piperidines; Platelet Aggregation Inhibitors; Pyrroles; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Recovery of Function; Somatosensory Cortex; Time Factors | 2014 |
Killing two birds with one stone: oral tofacitinib reverses alopecia universalis in a patient with plaque psoriasis.
Topics: Adult; Alopecia; Dose-Response Relationship, Drug; Humans; Male; Piperidines; Protein Kinase Inhibitors; Psoriasis; Pyrimidines; Pyrroles; Treatment Outcome | 2014 |
Herpes zoster and tofacitinib therapy in patients with rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Databases, Factual; Female; Herpes Zoster; Humans; Male; Middle Aged; Piperidines; Pyrimidines; Pyrroles; Treatment Outcome; Young Adult | 2014 |
Targeting SQSTM1/p62 induces cargo loading failure and converts autophagy to apoptosis via NBK/Bik.
Topics: Adaptor Proteins, Signal Transducing; Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Boronic Acids; Bortezomib; Cell Line, Tumor; Cells, Cultured; Cyclin T; Cyclin-Dependent Kinase 9; Cycloheximide; Flavonoids; Gene Expression Regulation; Heat-Shock Proteins; Humans; Indoles; Leupeptins; Membrane Proteins; Mice; Mice, Knockout; Mitochondrial Proteins; Piperidines; Protein Transport; Pyrazines; Pyrroles; RNA, Small Interfering; Sequestosome-1 Protein | 2014 |
Rheumatoid arthritis: can tofacitinib be used as first-line monotherapy for RA?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Piperidines; Pyrimidines; Pyrroles | 2014 |
Crystal structures of PRK1 in complex with the clinical compounds lestaurtinib and tofacitinib reveal ligand induced conformational changes.
Topics: Apoenzymes; Carbazoles; Crystallography, X-Ray; Furans; Humans; Ligands; Piperidines; Protein Conformation; Protein Kinase C; Protein Kinase Inhibitors; Pyrimidines; Pyrroles | 2014 |
Permeability analysis of neuroactive drugs through a dynamic microfluidic in vitro blood-brain barrier model.
Topics: Amines; Animals; Benzazepines; Biological Transport; Blood-Brain Barrier; Cell Survival; Cells, Cultured; Coculture Techniques; Cyclohexanecarboxylic Acids; Endothelial Cells; Ethosuximide; Gabapentin; gamma-Aminobutyric Acid; Indoles; L-Lactate Dehydrogenase; Mice; Microfluidic Analytical Techniques; Neuroglia; Permeability; Piperidines; Pyrroles; Quinoxalines; Rats; Rats, Sprague-Dawley; Sertraline; Sunitinib; Tetrahydronaphthalenes; Valine; Varenicline | 2014 |
Novel hinge-binding motifs for Janus kinase 3 inhibitors: a comprehensive structure-activity relationship study on tofacitinib bioisosteres.
Topics: Binding Sites; Hydrogen Bonding; Janus Kinase 3; Piperidines; Protein Kinase Inhibitors; Protein Structure, Tertiary; Pyrimidines; Pyrroles; Structure-Activity Relationship | 2014 |
Tofacitinib, a JAK inhibitor, inhibits human B cell activation in vitro.
Topics: B-Lymphocytes; Cell Differentiation; Humans; Immunoglobulin Class Switching; In Vitro Techniques; Janus Kinase 3; Lymphocyte Activation; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles | 2014 |
Functional characterization of BTK(C481S) mutation that confers ibrutinib resistance: exploration of alternative kinase inhibitors.
Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Antineoplastic Agents; B-Lymphocytes; Cell Line, Tumor; Cyclohexylamines; Dasatinib; Drug Resistance, Neoplasm; Female; Gene Expression; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Middle Aged; Mutation; Piperidines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrazoles; Pyrimidines; Pyrroles; RNA, Small Interfering; Signal Transduction; Structure-Activity Relationship; Thiazoles | 2015 |
JAK3 mutants transform hematopoietic cells through JAK1 activation, causing T-cell acute lymphoblastic leukemia in a mouse model.
Topics: Acute Disease; Animals; Cell Transformation, Neoplastic; Disease Models, Animal; Enzyme Activation; Janus Kinase 1; Janus Kinase 3; Leukemia, T-Cell; Male; Mice; Mice, Inbred BALB C; Mutation; Piperidines; Pyrimidines; Pyrroles; Signal Transduction; T-Lymphocytes | 2014 |
Could tofacitinib, the first oral small-molecule inhibitor proven for use in active rheumatoid arthritis (RA) patients with insufficient response to methotrexate, be the breakthrough drug for RA?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Piperidines; Pyrimidines; Pyrroles | 2014 |
Tofacitinib versus methotrexate in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Piperidines; Pyrimidines; Pyrroles | 2014 |
Tofacitinib versus methotrexate in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Piperidines; Pyrimidines; Pyrroles | 2014 |
Tofacitinib versus methotrexate in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Piperidines; Pyrimidines; Pyrroles | 2014 |
Scaffold hopping towards potent and selective JAK3 inhibitors: discovery of novel C-5 substituted pyrrolopyrazines.
Topics: Drug Design; Humans; Janus Kinase 3; Models, Molecular; Molecular Conformation; Molecular Structure; Phosphorylation; Piperidines; Protein Kinase Inhibitors; Pyrazines; Pyrimidines; Pyrroles; Structure-Activity Relationship | 2014 |
A validated LC-MS/MS assay for simultaneous quantification of methotrexate and tofacitinib in rat plasma: application to a pharmacokinetic study.
Topics: Animals; Chromatography, High Pressure Liquid; Male; Methotrexate; Piperidines; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry | 2015 |
Highly enantioselective intramolecular 1,3-dipolar cycloaddition: a route to piperidino-pyrrolizidines.
Topics: Cycloaddition Reaction; Magnetic Resonance Spectroscopy; Piperidines; Pyrroles; Stereoisomerism | 2015 |
Two birds that exclude each other: the Renbök phenomenon.
Topics: Alopecia; Humans; Male; Piperidines; Psoriasis; Pyrimidines; Pyrroles | 2015 |
White-to-brown metabolic conversion of human adipocytes by JAK inhibition.
Topics: Adipocytes, Brown; Adipocytes, White; Animals; Bone Morphogenetic Protein 7; Cell Differentiation; Cells, Cultured; Gene Expression Profiling; Hedgehog Proteins; Humans; Interferon-gamma; Ion Channels; Janus Kinase 1; Janus Kinase 3; Male; Mice; Mice, Inbred C57BL; Mitochondria; Mitochondrial Proteins; Obesity; Oxazines; Phosphorylation; Piperidines; Protein Kinase Inhibitors; Pyridines; Pyrimidines; Pyrroles; STAT1 Transcription Factor; STAT3 Transcription Factor; Tumor Necrosis Factor-alpha; Uncoupling Protein 1; Veratrum Alkaloids | 2015 |
Effects of tofacitinib on nucleic acid metabolism in human articular chondrocytes.
Topics: Aged; Aged, 80 and over; AMP Deaminase; Blotting, Western; Cells, Cultured; Chondrocytes; Female; Gene Expression Regulation; Humans; Janus Kinase 3; Male; Nucleic Acids; Osteoarthritis, Knee; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA | 2015 |
Rheumatoid arthritis in 2014: Exciting times for RA research.
Topics: Animals; Arthritis, Rheumatoid; Disease Models, Animal; Humans; Inflammation; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; T-Lymphocytes, Regulatory | 2015 |
Detection of Xeljanz enantiomers in diethyl amine active pharmaceutical ingredients and tablets.
Topics: Chromatography, High Pressure Liquid; Diethylamines; Janus Kinase 3; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Stereoisomerism; Tablets | 2015 |
Tofacitinib facilitates the expansion of myeloid-derived suppressor cells and ameliorates arthritis in SKG mice.
Topics: Animals; Arthritis, Experimental; CD4-Positive T-Lymphocytes; Cell Differentiation; Dendritic Cells; Female; Mice; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles | 2015 |
Development and validation of a RP-HPLC method for the quantitation of tofacitinib in rat plasma and its application to a pharmacokinetic study.
Topics: Animals; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Drug Stability; Male; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley | 2015 |
Evaluation of the effect of tofacitinib exposure on outcomes in kidney transplant patients.
Topics: Adult; Biopsy; Cyclosporine; Dose-Response Relationship, Drug; Female; Glomerular Filtration Rate; Graft Rejection; Humans; Immunosuppressive Agents; Kidney; Kidney Transplantation; Lymphoproliferative Disorders; Male; Middle Aged; Piperidines; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Risk Assessment; Risk Factors | 2015 |
Piperidine-3,4-diol and piperidine-3-ol derivatives of pyrrolo[2,1-f][1,2,4]triazine as inhibitors of anaplastic lymphoma kinase.
Topics: Anaplastic Lymphoma Kinase; Animals; Antineoplastic Agents; Cell Line, Tumor; Crystallography, X-Ray; Humans; Lymphoma, Large-Cell, Anaplastic; Mice, SCID; Models, Molecular; Piperidines; Protein Kinase Inhibitors; Pyrroles; Rats, Sprague-Dawley; Receptor Protein-Tyrosine Kinases; Triazines | 2015 |
Super-enhancers delineate disease-associated regulatory nodes in T cells.
Topics: Animals; Arthritis, Rheumatoid; Basic-Leucine Zipper Transcription Factors; Cell Differentiation; Cell Lineage; Enhancer Elements, Genetic; Gene Expression Regulation; Genetic Predisposition to Disease; Janus Kinase 3; Mice; Mice, Inbred C57BL; p300-CBP Transcription Factors; Piperidines; Pyrimidines; Pyrroles; RNA, Untranslated; T-Lymphocytes, Helper-Inducer; Transcription, Genetic | 2015 |
2,2- and 2,6-Diarylpiperidines by aryl migration within lithiated urea derivatives of tetrahydropyridines.
Topics: Cyclization; Lithium; Molecular Structure; Piperidines; Pyridines; Pyrroles; Urea | 2015 |
Tofacitinib, a novel JAK3 inhibitor, as a potential cause of distal symmetric polyneuropathy.
Topics: Adult; Humans; Male; Piperidines; Psoriasis; Pyrimidines; Pyrroles | 2016 |
Discovery of novel spiro 1,3,4-thiadiazolines as potent, orally bioavailable and brain penetrant KSP inhibitors.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Biomarkers; Blood-Brain Barrier; Brain Neoplasms; Cell Line, Tumor; Dogs; Drug Discovery; HCT116 Cells; Histones; Humans; Kinesins; Male; Mice; Permeability; Piperidines; Pyrimidines; Pyrroles; Rats; Spiro Compounds; Thiadiazoles; Thiones; Tubulin Modulators; Xenograft Model Antitumor Assays | 2015 |
Potent anti-inflammatory effects of the narrow spectrum kinase inhibitor RV1088 on rheumatoid arthritis synovial membrane cells.
Topics: Acetamides; Adalimumab; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Dasatinib; Dose-Response Relationship, Drug; Humans; Inflammation Mediators; Interleukin-6; Interleukin-8; Macrophages; Monocytes; Naphthalenes; Oxazines; Piperidines; Primary Cell Culture; Protein Kinase Inhibitors; Pyrazoles; Pyridines; Pyrimidines; Pyrroles; RNA, Small Interfering; Signal Transduction; Synovial Membrane; Tumor Necrosis Factor-alpha; Urea | 2015 |
Smad3 deficiency protects mice from obesity-induced podocyte injury that precedes insulin resistance.
Topics: Animals; Cells, Cultured; Dietary Fats; Enzyme Inhibitors; Fibrosis; Flavonoids; Gene Knockdown Techniques; Insulin; Insulin Resistance; Isoquinolines; Male; Mice; Mice, Inbred C57BL; Microfilament Proteins; Mitochondria; Obesity; Palmitic Acid; Phosphorylation; Piperidines; Podocytes; Protective Factors; Protein Kinase Inhibitors; Pyridines; Pyrroles; Signal Transduction; Smad3 Protein | 2015 |
Oral tofacitinib for psoriasis: what happens with interrupted treatment?
Topics: Dermatologic Agents; Female; Humans; Male; Piperidines; Protein Kinase Inhibitors; Psoriasis; Pyrimidines; Pyrroles | 2015 |
T Helper 2 Cytokine Signaling in Bone Marrow-Derived Fibroblasts: A Target for Renal Fibrosis.
Topics: Animals; Fibroblasts; Janus Kinase 3; Kidney; Male; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; STAT6 Transcription Factor | 2015 |
JAK3/STAT6 Stimulates Bone Marrow-Derived Fibroblast Activation in Renal Fibrosis.
Topics: Actins; Animals; Apoptosis; Bone Marrow Transplantation; Cells, Cultured; Collagen Type I; Extracellular Matrix Proteins; Fibroblasts; Fibronectins; Fibrosis; Interleukin-13; Interleukin-4; Janus Kinase 3; Kidney; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Monocytes; Myofibroblasts; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Signal Transduction; STAT6 Transcription Factor; Ureteral Obstruction | 2015 |
Do we need more psoriasis therapies?
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Immunoglobulin G; Male; Piperidines; Protein Kinase Inhibitors; Psoriasis; Pyrimidines; Pyrroles; Receptors, Tumor Necrosis Factor | 2015 |
Renal fibrosis: Activation of JAK3/STAT6 contributes to the development of renal fibrosis.
Topics: Animals; Fibroblasts; Janus Kinase 3; Kidney; Male; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; STAT6 Transcription Factor | 2015 |
Tofacitinib Citrate for the Treatment of Vitiligo: A Pathogenesis-Directed Therapy.
Topics: Administration, Oral; Female; Humans; Janus Kinase 1; Janus Kinase 3; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Skin Pigmentation; Treatment Outcome; Vitiligo | 2015 |
Topically Administered Janus-Kinase Inhibitors Tofacitinib and Oclacitinib Display Impressive Antipruritic and Anti-Inflammatory Responses in a Model of Allergic Dermatitis.
Topics: Administration, Oral; Administration, Topical; Animals; Anti-Inflammatory Agents; Antipruritics; Cytokines; Dermatitis, Allergic Contact; Disease Models, Animal; Female; Inflammation; Janus Kinases; Lymph Nodes; Mice; Mice, Inbred BALB C; Piperidines; Pruritus; Pyrimidines; Pyrroles; Skin; Sulfonamides | 2015 |
Aggression behaviour induced by oral administration of the Janus-kinase inhibitor tofacitinib, but not oclacitinib, under stressful conditions.
Topics: Administration, Oral; Aggression; Animals; Anti-Allergic Agents; Anti-Inflammatory Agents; Behavior, Animal; Brain; Dermatitis, Atopic; Disease Models, Animal; Female; Janus Kinases; Male; Mice, Inbred BALB C; Piperidines; Protein Kinase Inhibitors; Pruritus; Pyrimidines; Pyrroles; Stress, Psychological; Sulfonamides; Toluene 2,4-Diisocyanate | 2015 |
Treatment of recalcitrant atopic dermatitis with the oral Janus kinase inhibitor tofacitinib citrate.
Topics: Administration, Oral; Adolescent; Adult; Dermatitis, Atopic; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Janus Kinases; Male; Middle Aged; Piperidines; Pyrimidines; Pyrroles; Risk Assessment; Sampling Studies; Severity of Illness Index; Treatment Outcome; Young Adult | 2015 |
Cost-effectiveness of Tofacitinib in the Treatment of Moderate to Severe Rheumatoid Arthritis in South Korea.
Topics: Adult; Arthritis, Rheumatoid; Cost-Benefit Analysis; Female; Humans; Janus Kinase 3; Male; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Quality of Life; Republic of Korea; Severity of Illness Index; Surveys and Questionnaires | 2015 |
Jak3, STAT3, and STAT5 inhibit expression of miR-22, a novel tumor suppressor microRNA, in cutaneous T-Cell lymphoma.
Topics: Cell Line, Tumor; Genes, Tumor Suppressor; Humans; Janus Kinase 3; Lymphoma, T-Cell, Cutaneous; MicroRNAs; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Signal Transduction; Skin Neoplasms; STAT3 Transcription Factor; STAT5 Transcription Factor; Transfection | 2015 |
Pulmonary Cryptococcosis in the Setting of Tofacitinib Therapy for Psoriasis.
Topics: Aged; Cryptococcosis; Humans; Lung Diseases; Male; Piperidines; Protein Kinase Inhibitors; Psoriasis; Pyrimidines; Pyrroles | 2015 |
Differences in gene expression and alterations in cell cycle of acute myeloid leukemia cell lines after treatment with JAK inhibitors.
Topics: bcl-X Protein; Cell Cycle; Cell Line, Tumor; Cyclin D1; Down-Regulation; Gene Expression; Humans; Imidazoles; Janus Kinases; Leukemia, Myeloid, Acute; Nitriles; Piperidines; Protein Kinase Inhibitors; Pyrazoles; Pyridazines; Pyrimidines; Pyrroles; Pyrrolidines; Sulfonamides | 2015 |
Structure-Based Design of a Small Molecule CD4-Antagonist with Broad Spectrum Anti-HIV-1 Activity.
Topics: Anti-HIV Agents; CD4 Antigens; Cell Fusion; Cell Line; HIV Envelope Protein gp120; HIV Reverse Transcriptase; HIV-1; Humans; Hydrogen Bonding; Models, Molecular; Molecular Conformation; Oxalates; Piperidines; Protein Conformation; Pyrroles; Receptors, CCR5; Receptors, CXCR4; Reverse Transcriptase Inhibitors; Stereoisomerism; Structure-Activity Relationship; Thiazoles; Virus Internalization | 2015 |
Tofacitinib regulates synovial inflammation in psoriatic arthritis, inhibiting STAT activation and induction of negative feedback inhibitors.
Topics: Adult; Arthritis, Psoriatic; Cell Movement; Cells, Cultured; Female; Fibroblasts; Humans; Inflammation Mediators; Janus Kinase 3; Male; Middle Aged; Molecular Targeted Therapy; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Signal Transduction; STAT Transcription Factors; Synovial Membrane; Synovitis; Tissue Culture Techniques | 2016 |
Suppress for Success: A JAK Inhibitor for Adjunct Therapy of Tuberculosis.
Topics: Animals; Female; Humans; Piperidines; Pyrimidines; Pyrroles; Tuberculosis | 2015 |
Efficacy of Adjunctive Tofacitinib Therapy in Mouse Models of Tuberculosis.
Topics: Animals; Cytokines; Disease Models, Animal; Female; Humans; Mice; Mice, Inbred BALB C; Piperidines; Pyrimidines; Pyrroles; Tuberculosis | 2015 |
Binding of Janus kinase inhibitor tofacitinib with human serum albumin: multi-technique approach.
Topics: Calorimetry, Differential Scanning; Circular Dichroism; Humans; Hydrogen-Ion Concentration; Janus Kinases; Models, Molecular; Molecular Conformation; Molecular Docking Simulation; Molecular Dynamics Simulation; Piperidines; Protein Binding; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Serum Albumin; Spectrometry, Fluorescence; Structure-Activity Relationship; Thermodynamics | 2016 |
Tofacitinib as a novel salvage therapy for refractory T-cell large granular lymphocytic leukemia.
Topics: Humans; Leukemia, Large Granular Lymphocytic; Mutation; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Salvage Therapy; STAT3 Transcription Factor | 2015 |
Role of Janus Kinase 3 in Predisposition to Obesity-associated Metabolic Syndrome.
Topics: Animals; Body Weight; Caco-2 Cells; Cytokines; Diet, High-Fat; Disease Models, Animal; Genetic Predisposition to Disease; Glucose Tolerance Test; Humans; Immunity, Innate; Inflammation; Insulin; Janus Kinase 3; Liver; Male; Metabolic Syndrome; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Fluorescence; Obesity; Organ Size; Piperidines; Pyrimidines; Pyrroles; Risk Factors; Signal Transduction; Toll-Like Receptors | 2015 |
Janus Kinase Inhibitor Tofacitinib Shows Potent Efficacy in a Mouse Model of Autoimmune Lymphoproliferative Syndrome (ALPS).
Topics: Animals; Autoimmune Lymphoproliferative Syndrome; Disease Models, Animal; fas Receptor; Humans; Immunoglobulins; Janus Kinase 3; Mice; Mice, Inbred C57BL; Mice, Inbred MRL lpr; Mutation; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; T-Lymphocyte Subsets; T-Lymphocytes, Regulatory | 2015 |
The dual-acting H3 receptor antagonist and AChE inhibitor UW-MD-71 dose-dependently enhances memory retrieval and reverses dizocilpine-induced memory impairment in rats.
Topics: Animals; Avoidance Learning; Benzothiazoles; Cholinesterase Inhibitors; Disease Models, Animal; Dizocilpine Maleate; Donepezil; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Histamine H3 Antagonists; Indans; Male; Memory; Memory Disorders; Nootropic Agents; Phenoxypropanolamines; Piperidines; Pyrilamine; Pyrroles; Quinazolines; Random Allocation; Rats, Wistar; Receptors, Histamine H3 | 2016 |
High Affinity Pharmacological Profiling of Dual Inhibitors Targeting RET and VEGFR2 in Inhibition of Kinase and Angiogeneis Events in Medullary Thyroid Carcinoma.
Topics: Angiogenesis Inhibitors; Anilides; Carcinoma, Neuroendocrine; Databases, Chemical; Drug Discovery; Humans; Imidazoles; Indoles; Molecular Docking Simulation; Molecular Structure; Niacinamide; Oligonucleotides; Piperidines; Protein Binding; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-ret; Pyrazoles; Pyridines; Pyrimidines; Pyrroles; Quinazolines; Sunitinib; Thyroid Neoplasms; Vascular Endothelial Growth Factor Receptor-2 | 2015 |
Tofacitinib Citrate for the Treatment of Nail Dystrophy Associated With Alopecia Universalis.
Topics: Adult; Alopecia; Female; Humans; Janus Kinases; Male; Nail Diseases; Nails; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles | 2016 |
New Zealand Society of Gastroenterology Guidelines for the Management of Refractory Ulcerative Colitis.
Topics: Adalimumab; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Appendectomy; Azathioprine; Colitis, Ulcerative; Cyclosporine; Drug Resistance; Drug Therapy, Combination; Fecal Microbiota Transplantation; Gastrointestinal Agents; Humans; Immunosuppressive Agents; Infliximab; Leukapheresis; Mercaptopurine; Mesalamine; Methotrexate; New Zealand; Pediatrics; Piperidines; Proctocolectomy, Restorative; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Recurrence; Severity of Illness Index; Tacrolimus; Tumor Necrosis Factor-alpha | 2015 |
Simultaneous inhibition of JAK and SYK kinases ameliorates chronic and destructive arthritis in mice.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Cyclohexylamines; Disease Models, Animal; Drug Therapy, Combination; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Immunophenotyping; Intracellular Signaling Peptides and Proteins; Janus Kinases; Male; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Piperidines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrimidines; Pyrroles; Syk Kinase | 2015 |
Anti-inflammatory effect of topical administration of tofacitinib on corneal inflammation.
Topics: Administration, Topical; Animals; Cells, Cultured; Cornea; Corneal Neovascularization; Disease Models, Animal; Janus Kinase 3; Keratitis; Male; Mice; Mice, Inbred BALB C; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles | 2016 |
Staphylococcal enterotoxin A (SEA) stimulates STAT3 activation and IL-17 expression in cutaneous T-cell lymphoma.
Topics: Cell Line, Tumor; Coculture Techniques; Enterotoxins; Female; Gene Expression Regulation, Neoplastic; Humans; Interleukin Receptor Common gamma Subunit; Interleukin-17; Lymphocyte Activation; Male; Neoplasm Proteins; Piperidines; Pyrimidines; Pyrroles; Sezary Syndrome; STAT3 Transcription Factor; T-Lymphocytes | 2016 |
Interaction of new kinase inhibitors cabozantinib and tofacitinib with human serum alpha-1 acid glycoprotein. A comprehensive spectroscopic and molecular Docking approach.
Topics: Anilides; Humans; Molecular Docking Simulation; Orosomucoid; Piperidines; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Pyridines; Pyrimidines; Pyrroles; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Thermodynamics | 2016 |
Tofacitinib, an oral Janus kinase inhibitor, for the treatment of chronic plaque psoriasis: Long-term efficacy and safety results from 2 randomized phase-III studies and 1 open-label long-term extension study.
Topics: Administration, Oral; Adult; Aged; Chronic Disease; Clinical Trials, Phase III as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Janus Kinases; Male; Middle Aged; Patient Safety; Piperidines; Protein Kinase Inhibitors; Psoriasis; Pyrimidines; Pyrroles; Quality of Life; Randomized Controlled Trials as Topic; Severity of Illness Index; Time Factors; Treatment Outcome; Young Adult | 2016 |
Targeting protein kinase C in mantle cell lymphoma.
Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Antineoplastic Agents; Cell Death; Drug Resistance, Neoplasm; Humans; Lymphoma, Mantle-Cell; MAP Kinase Signaling System; Molecular Targeted Therapy; Phosphorylation; Piperidines; Protein Kinase C; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrazoles; Pyrimidines; Pyrroles; Quinazolines; Tumor Cells, Cultured | 2016 |
Sunitinib, a Clinically Used Anticancer Drug, Is a Potent AChE Inhibitor and Attenuates Cognitive Impairments in Mice.
Topics: Acetylcholinesterase; Animals; Antineoplastic Agents; Cholinergic Antagonists; Cholinesterase Inhibitors; Cognition Disorders; Disease Models, Animal; Donepezil; Dose-Response Relationship, Drug; Exploratory Behavior; Indans; Indoles; Male; Maze Learning; Mice; Mice, Inbred ICR; Molecular Docking Simulation; Piperidines; Pyrroles; Scopolamine; Sunitinib | 2016 |
Interspecies scaling of urinary excretory amounts of nine drugs belonging to different therapeutic areas with diverse chemical structures - accurate prediction of the human urinary excretory amounts.
Topics: Animals; Benzodiazepines; Carbamates; Carbazoles; Cephapirin; Humans; Indoles; Labetalol; Nevirapine; Olanzapine; Pharmaceutical Preparations; Piperidines; Prospective Studies; Pyrimidines; Pyrroles; Species Specificity; Voriconazole | 2017 |
Initial Experience With Tofacitinib in Clinical Practice: Treatment Patterns and Costs of Tofacitinib Administered as Monotherapy or in Combination With Conventional Synthetic DMARDs in 2 US Health Care Claims Databases.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Databases, Factual; Drug Costs; Female; Humans; Male; Medication Adherence; Middle Aged; Piperidines; Pyrimidines; Pyrroles; Retrospective Studies | 2016 |
Real-world comparative risks of herpes virus infections in tofacitinib and biologic-treated patients with rheumatoid arthritis.
Topics: Adult; Age Factors; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Female; Herpes Simplex; Herpes Zoster; Herpesviridae Infections; Humans; Incidence; Male; Middle Aged; Piperidines; Proportional Hazards Models; Pyrimidines; Pyrroles; Risk Factors; Sex Factors | 2016 |
Elucidating the Mechanism of Tofacitinib Oxidative Decyanation.
Topics: Cytochrome P-450 Enzyme System; Humans; In Vitro Techniques; Microsomes, Liver; Oxidation-Reduction; Oxygen; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles | 2016 |
Treatment of an alopecia areata patient with tofacitinib results in regrowth of hair and changes in serum and skin biomarkers.
Topics: Adult; Alopecia Areata; Biomarkers; Female; Humans; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Skin | 2016 |
Tofacitinib Citrate for Refractory Cutaneous Dermatomyositis: An Alternative Treatment.
Topics: Administration, Oral; Adult; Dermatomyositis; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resistance, Multiple; Female; Follow-Up Studies; Humans; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Sampling Studies; Severity of Illness Index; Treatment Outcome | 2016 |
Action of methotrexate and tofacitinib on directly stimulated and bystander-activated lymphocytes.
Topics: Antimetabolites, Antineoplastic; Cells, Cultured; Cytokines; Humans; Lymphocyte Activation; Lymphocytes; Methotrexate; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles | 2016 |
Brief Report: Risk of Gastrointestinal Perforation Among Rheumatoid Arthritis Patients Receiving Tofacitinib, Tocilizumab, or Other Biologic Treatments.
Topics: Abatacept; Adult; Age Factors; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Databases, Factual; Diverticulitis; Esophageal Perforation; Female; Gastroesophageal Reflux; Glucocorticoids; Humans; Incidence; Intestinal Perforation; Male; Medicare; Middle Aged; Peptic Ulcer; Piperidines; Prednisone; Proportional Hazards Models; Pyrimidines; Pyrroles; Risk Factors; Rituximab; Tumor Necrosis Factor-alpha; United States | 2016 |
Targeting the IFN-γ/CXCL10 pathway in lichen planus.
Topics: Chemokine CXCL10; Chemokine CXCL9; Enzyme Inhibitors; Humans; Inflammation; Interferon-gamma; Lichen Planus; Models, Theoretical; Piperidines; Promoter Regions, Genetic; Pyrimidines; Pyrroles; Signal Transduction; Skin; Treatment Outcome | 2016 |
JAK3-STAT pathway blocking benefits in experimental lupus nephritis.
Topics: Animals; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique; Gene Expression Profiling; Janus Kinase 3; Lupus Nephritis; Mice; Mice, Inbred NZB; Piperidines; Polymerase Chain Reaction; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Signal Transduction; STAT Transcription Factors; Transcriptome | 2016 |
Pregnancy Outcomes in the Tofacitinib Safety Databases for Rheumatoid Arthritis and Psoriasis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Databases, Factual; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Infant, Newborn; Methotrexate; Piperidines; Pregnancy; Pregnancy Outcome; Protein Kinase Inhibitors; Psoriasis; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Young Adult | 2016 |
High-content screening identifies kinase inhibitors that overcome venetoclax resistance in activated CLL cells.
Topics: Adenine; bcl-X Protein; Bridged Bicyclo Compounds, Heterocyclic; Cellular Microenvironment; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Resistance, Neoplasm; Humans; Imaging, Three-Dimensional; Indoles; Leukemia, Lymphocytic, Chronic, B-Cell; Mutation; Piperidines; Protein Kinase Inhibitors; Purines; Pyrazoles; Pyrimidines; Pyrroles; Quinazolinones; Reproducibility of Results; Signal Transduction; Stromal Cells; Sulfonamides; Sunitinib; Up-Regulation | 2016 |
Efficacy of tofacitinib in treatment of alopecia universalis in two patients.
Topics: Adult; Alopecia; Humans; Male; Piperidines; Pyrimidines; Pyrroles; Treatment Outcome | 2016 |
Successful Treatment of Refractory Alopecia Areata Universalis and Psoriatic Arthritis, But Not of Plaque Psoriasis with Tofacitinib in a Young Woman.
Topics: Adolescent; Alopecia; Alopecia Areata; Arthritis, Psoriatic; Female; Humans; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Retreatment | 2017 |
Tofacitinib Ameliorates Murine Lupus and Its Associated Vascular Dysfunction.
Topics: Animals; Female; Lupus Erythematosus, Systemic; Mice; Mice, Inbred MRL lpr; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Vascular Diseases | 2017 |
Cardiovascular safety findings in patients with rheumatoid arthritis treated with tofacitinib, an oral Janus kinase inhibitor.
Topics: Arthritis, Rheumatoid; Blood Pressure; Cardiovascular Diseases; Cholesterol, HDL; Cholesterol, LDL; Clinical Trials, Phase III as Topic; Heart Failure; Humans; Hyperlipidemias; Hypertension; Incidence; Janus Kinases; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Triglycerides | 2016 |
The European League Against Rheumatism (EULAR) - 17th Annual European Congress of Rheumatology (June 8-11, 2016 - London, UK).
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Humans; Piperidines; Pyrimidines; Pyrroles; Rheumatic Diseases; Rheumatology | 2016 |
Use of a risk characterisation approach to contextualise the safety profile of new rheumatoid arthritis treatments: a case study using tofacitinib.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Neoplasms; Opportunistic Infections; Piperidines; Pyrimidines; Pyrroles; Risk Assessment | 2017 |
Effects of tofacitinib on cardiovascular risk factors and cardiovascular outcomes based on phase III and long-term extension data in patients with plaque psoriasis.
Topics: Adult; Blood Pressure; C-Reactive Protein; Cardiovascular Diseases; Cholesterol; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Comorbidity; Dyslipidemias; Female; Glycated Hemoglobin; Humans; Male; Metabolic Syndrome; Middle Aged; Piperidines; Protein Kinase Inhibitors; Psoriasis; Pyrimidines; Pyrroles; Risk Factors; Treatment Outcome; Triglycerides | 2016 |
Small Molecules for Psoriasis.
Topics: Acitretin; Administration, Oral; Dermatologic Agents; Evidence-Based Medicine; Humans; Piperidines; Psoriasis; PUVA Therapy; Pyrimidines; Pyrroles; Treatment Outcome | 2016 |
Update on TNF Inhibitors.
Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Arthritis, Psoriatic; Cardiovascular Diseases; Certolizumab Pegol; Clinical Trials as Topic; Clinical Trials, Phase III as Topic; Dermatologic Agents; Etanercept; Humans; Infliximab; Piperidines; Psoriasis; Pyrimidines; Pyrroles; Treatment Outcome; Tumor Necrosis Factor-alpha; Ustekinumab | 2016 |
Insights into kinetic mechanism of Janus kinase 3 and its inhibition by tofacitinib.
Topics: Adenosine Triphosphatases; Animals; Catalysis; Dose-Response Relationship, Drug; Humans; Inhibitory Concentration 50; Insecta; Janus Kinase 3; Kinetics; Mutation; Phosphorylation; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Sf9 Cells; Signal Transduction; Solvents; Viscosity | 2016 |
Tofacitinib for polyarteritis nodosa: a tailored therapy.
Topics: Adult; Biopsy, Needle; Computed Tomography Angiography; Dose-Response Relationship, Drug; Drug Administration Schedule; Follow-Up Studies; Humans; Immunohistochemistry; Male; Molecular Targeted Therapy; Piperidines; Polyarteritis Nodosa; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Recurrence; Severity of Illness Index; STAT3 Transcription Factor; Time Factors; Treatment Outcome | 2016 |
Familial chilblain lupus due to a gain-of-function mutation in STING.
Topics: Adult; Blotting, Western; Chilblains; Family; Female; Greece; Humans; Interferon Type I; Interferon-beta; Lupus Erythematosus, Cutaneous; Male; Membrane Proteins; Microscopic Angioscopy; Molecular Docking Simulation; Mutation; Pedigree; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Skin | 2017 |
Tofacitinib and analogs as inhibitors of the histone kinase PRK1 (PKN1).
Topics: Dose-Response Relationship, Drug; Humans; Models, Molecular; Molecular Structure; Piperidines; Protein Kinase C; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Structure-Activity Relationship | 2016 |
An Economic Evaluation of Tofacitinib Treatment in Rheumatoid Arthritis: Modeling the Cost of Treatment Strategies in the United States.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cost-Benefit Analysis; Humans; Models, Economic; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Treatment Outcome; United States | 2016 |
A case of refractory dermatomyositis responsive to tofacitinib.
Topics: Azathioprine; Dermatomyositis; Female; Humans; Immunoglobulins, Intravenous; Immunosuppressive Agents; Methotrexate; Middle Aged; Mycophenolic Acid; Piperidines; Pyrimidines; Pyrroles; Retreatment; Treatment Failure; Treatment Outcome | 2017 |
Safety and efficacy of the JAK inhibitor tofacitinib citrate in patients with alopecia areata.
Topics: Adult; Aged; Alopecia Areata; Female; Humans; Janus Kinase Inhibitors; Male; Middle Aged; Piperidines; Pyrimidines; Pyrroles; United States; Young Adult | 2016 |
Effects of the Janus Kinase Inhibitor, Tofacitinib, on Testicular Leydig Cell Hyperplasia and Adenoma in Rats, and on Prolactin Signaling in Cultured Primary Rat Leydig Cells.
Topics: Adenoma; Animals; Hyperplasia; Leydig Cells; Male; Piperidines; Prolactin; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Rats; Signal Transduction; Testis | 2017 |
Anti-inflammatory potential of PI3Kδ and JAK inhibitors in asthma patients.
Topics: Adult; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage Fluid; Case-Control Studies; CD3 Complex; Cells, Cultured; Class I Phosphatidylinositol 3-Kinases; Dexamethasone; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Inflammation Mediators; Interferon-gamma; Interleukin-13; Interleukin-17; Janus Kinase Inhibitors; Janus Kinases; Lung; Lymphocyte Activation; Male; Middle Aged; Molecular Targeted Therapy; Piperidines; Pyrimidines; Pyrroles; Signal Transduction; T-Lymphocytes | 2016 |
Successful treatment of palmoplantar pustulosis with rheumatoid arthritis, with tofacitinib: Impact of this JAK inhibitor on T-cell differentiation.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Janus Kinase Inhibitors; Middle Aged; Piperidines; Psoriasis; Pyrimidines; Pyrroles; Treatment Outcome | 2016 |
JAK inhibitors: A broadening approach in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Biosimilar Pharmaceuticals; Humans; Janus Kinase 3; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles | 2016 |
Tofacitinib induces G1 cell-cycle arrest and inhibits tumor growth in Epstein-Barr virus-associated T and natural killer cell lymphoma cells.
Topics: Animals; Apoptosis; Biomarkers; Cell Line, Tumor; Disease Models, Animal; Epstein-Barr Virus Infections; G1 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Viral; Herpesvirus 4, Human; Humans; Janus Kinase 3; Killer Cells, Natural; Lymphocyte Activation; Lymphoma, T-Cell; Mice; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; STAT5 Transcription Factor; T-Lymphocytes; Tumor Burden; Xenograft Model Antitumor Assays | 2016 |
Identification of 4-(2-furanyl)pyrimidin-2-amines as Janus kinase 2 inhibitors.
Topics: Amines; Cell Line; Humans; Janus Kinase 2; Janus Kinase 3; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles | 2017 |
Impact of tofacitinib treatment on human B-cells in vitro and in vivo.
Topics: Antibody Formation; Arthritis, Rheumatoid; B-Lymphocytes; Cells, Cultured; Cytidine Deaminase; Humans; Immunoglobulin Class Switching; Immunomodulation; Interleukin Receptor Common gamma Subunit; Lymphocyte Activation; Lymphocyte Count; Piperidines; Plasma Cells; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Signal Transduction | 2017 |
Tofacitinib for the treatment of alopecia areata and variants in adolescents.
Topics: Adolescent; Alopecia; Alopecia Areata; Female; Humans; Male; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Retrospective Studies; Severity of Illness Index; Treatment Outcome | 2017 |
Tofacitinib for the treatment of severe alopecia areata and variants: A study of 90 patients.
Topics: Adolescent; Adult; Aged; Alopecia; Alopecia Areata; Female; Humans; Male; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Retrospective Studies; Severity of Illness Index; Treatment Outcome; Young Adult | 2017 |
Reversal of Alopecia Universalis by Tofacitinib: A Case Report.
Topics: Adult; Alopecia; Female; Humans; Janus Kinase 1; Janus Kinase 3; Janus Kinase Inhibitors; Male; Piperidines; Pyrimidines; Pyrroles; Treatment Outcome; Young Adult | 2016 |
Next generation of small molecules in inflammatory bowel disease.
Topics: Administration, Oral; Anti-Inflammatory Agents; Colitis, Ulcerative; Crohn Disease; Humans; Immunologic Factors; Indans; Inflammatory Bowel Diseases; Oxadiazoles; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Quinolones; Randomized Controlled Trials as Topic; Treatment Outcome; Tumor Necrosis Factor-alpha | 2017 |
Model-Informed Development and Registration of a Once-Daily Regimen of Extended-Release Tofacitinib.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Area Under Curve; Delayed-Action Preparations; Drug Administration Schedule; Drug Approval; Humans; Janus Kinases; Male; Metabolic Clearance Rate; Models, Animal; Models, Biological; Neoplasms; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Rats, Sprague-Dawley; Therapeutic Equivalency; Treatment Outcome; United States; United States Food and Drug Administration | 2017 |
EGF Induced RET Inhibitor Resistance in CCDC6-RET Lung Cancer Cells.
Topics: Adenocarcinoma; Cell Line, Tumor; Cetuximab; Drug Resistance, Neoplasm; Epidermal Growth Factor; ErbB Receptors; fms-Like Tyrosine Kinase 3; Gefitinib; Gene Rearrangement; Hepatocyte Growth Factor; Humans; Indoles; Lung Neoplasms; MAP Kinase Signaling System; Mutation; Niacinamide; Phenylurea Compounds; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Mas; Proto-Oncogene Proteins c-ret; Pyrroles; Quinazolines; RNA, Small Interfering; Signal Transduction; Sorafenib; Sunitinib | 2017 |
Potential Involvement of the IL-6/JAK/STAT3 Pathway in the Pathogenesis of Intervertebral Disc Degeneration.
Topics: Adult; Aged; Animals; Annulus Fibrosus; Disease Models, Animal; Female; Humans; Interleukin-6; Intervertebral Disc Degeneration; Janus Kinases; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Rats; Rats, Wistar; Signal Transduction; STAT3 Transcription Factor; Suppressor of Cytokine Signaling 3 Protein | 2017 |
Evaluation of Real-World Experience with Tofacitinib Compared with Adalimumab, Etanercept, and Abatacept in RA Patients with 1 Previous Biologic DMARD: Data from a U.S. Administrative Claims Database.
Topics: Abatacept; Adalimumab; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Databases, Factual; Etanercept; Female; Humans; Insurance Claim Review; Male; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Retrospective Studies; United States | 2016 |
Treatment of Hypereosinophilic Syndrome with Cutaneous Involvement with the JAK Inhibitors Tofacitinib and Ruxolitinib.
Topics: Adult; Aged; Female; Humans; Hypereosinophilic Syndrome; Janus Kinase Inhibitors; Male; Middle Aged; Nitriles; Piperidines; Pyrazoles; Pyrimidines; Pyrroles; Skin Diseases | 2017 |
Involvement of JAK1, JAK2, and JAK3 in Stimulation of Functional Activity of Mesenchymal Progenitor Cells by Fibroblast Growth Factor.
Topics: Animals; Bone Marrow Cells; Cell Differentiation; Colony-Forming Units Assay; Fibroblast Growth Factors; Fibroblasts; Gene Expression Regulation; Janus Kinase 1; Janus Kinase 2; Janus Kinase 3; Male; Mesenchymal Stem Cells; Mice; Mice, Inbred CBA; Piperidines; Primary Cell Culture; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Signal Transduction; Tyrphostins | 2016 |
Brief Report: Remission Rates With Tofacitinib Treatment in Rheumatoid Arthritis: A Comparison of Various Remission Criteria.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials, Phase III as Topic; Humans; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Remission Induction | 2017 |
Ulcerative Colitis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal, Humanized; Biosimilar Pharmaceuticals; Colitis, Ulcerative; Gastrointestinal Agents; Glucocorticoids; Humans; Immunosuppressive Agents; Infliximab; Integrins; Janus Kinases; Mercaptopurine; Mesalamine; Piperidines; Pyrimidines; Pyrroles; Remission Induction; Tumor Necrosis Factor-alpha | 2016 |
JAK-inhibitor tofacitinib suppresses interferon alfa production by plasmacytoid dendritic cells and inhibits arthrogenic and antiviral effects of interferon alfa.
Topics: Apoptosis; Cell Line, Tumor; Dendritic Cells; Dose-Response Relationship, Drug; Gene Expression Regulation; Hepacivirus; Humans; Interferon-alpha; Interleukin-3; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Pyrimidines; Pyrroles; STAT Transcription Factors; Virus Replication | 2017 |
Inhibition of JAK3 and PKC via Immunosuppressive Drugs Tofacitinib and Sotrastaurin Inhibits Proliferation of Human B Lymphocytes In Vitro.
Topics: Apoptosis; B-Lymphocytes; CD40 Ligand; Cell Proliferation; Cells, Cultured; Humans; Immunosuppressive Agents; Interleukin-10; Interleukin-2; Interleukins; Janus Kinase 3; Leukocytes, Mononuclear; Lymphocyte Activation; Piperidines; Protein Kinase C; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Quinazolines; Sirolimus | 2016 |
A biophysical and computational study unraveling the molecular interaction mechanism of a new Janus kinase inhibitor Tofacitinib with bovine serum albumin.
Topics: Animals; Binding Sites; Biophysical Phenomena; Cattle; Circular Dichroism; Dynamic Light Scattering; Hydrogen Bonding; Janus Kinase Inhibitors; Models, Molecular; Molecular Docking Simulation; Piperidines; Protein Binding; Pyrimidines; Pyrroles; Serum Albumin, Bovine; Spectrometry, Fluorescence; Thermodynamics | 2017 |
AS2553627, a novel JAK inhibitor, prevents chronic rejection in rat cardiac allografts.
Topics: Allografts; Animals; Cell Count; Cell Proliferation; Drug Interactions; Graft Rejection; Heart Transplantation; Humans; Janus Kinases; Piperidines; Protein Kinase Inhibitors; Pyrroles; Reticulocytes; Tacrolimus; Time Factors | 2017 |
Analysis of haematological changes in tofacitinib-treated patients with rheumatoid arthritis across phase 3 and long-term extension studies.
Topics: Adult; Aged; Arthritis, Rheumatoid; Blood Sedimentation; C-Reactive Protein; Cell Count; Clinical Trials, Phase III as Topic; Fatigue; Female; Hemoglobins; Humans; Longitudinal Studies; Lymphocyte Count; Male; Middle Aged; Neutrophils; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Treatment Outcome | 2017 |
Tofacitinib relieves symptoms of stimulator of interferon genes (STING)-associated vasculopathy with onset in infancy caused by 2 de novo variants in TMEM173.
Topics: Child; Humans; Male; Membrane Proteins; Mutation; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Vascular Diseases | 2017 |
Tolerogenic Dendritic Cells Generated with Tofacitinib Ameliorate Experimental Autoimmune Encephalomyelitis through Modulation of Th17/Treg Balance.
Topics: Animals; CD4 Lymphocyte Count; Cells, Cultured; Dendritic Cells; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Immune Tolerance; Immunotherapy, Adoptive; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; T-Lymphocytes, Regulatory; Th1 Cells; Th17 Cells | 2016 |
Rheumatoid arthritis: TAK-ing the road to suppress inflammation in synovial fibroblasts.
Topics: Arthritis, Rheumatoid; Clinical Trials, Phase II as Topic; Cytokines; Fibroblasts; Humans; Lactones; MAP Kinase Kinase Kinases; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Resorcinols; Synovial Membrane | 2017 |
Tofacitinib ameliorates inflammation in a rat model of airway neutrophilia induced by inhaled LPS.
Topics: Animals; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Inflammation; Janus Kinases; Lipopolysaccharides; Lung; Male; Neutrophils; Phosphorylation; Piperidines; Pneumonia; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Signal Transduction; STAT3 Transcription Factor | 2017 |
Molecular modeling study of CP-690550 derivatives as JAK3 kinase inhibitors through combined 3D-QSAR, molecular docking, and dynamics simulation techniques.
Topics: Binding Sites; Hydrophobic and Hydrophilic Interactions; Inhibitory Concentration 50; Janus Kinase 3; Molecular Docking Simulation; Molecular Dynamics Simulation; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Quantitative Structure-Activity Relationship; Thermodynamics | 2017 |
Long-term safety of tofacitinib for the treatment of rheumatoid arthritis up to 8.5 years: integrated analysis of data from the global clinical trials.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Clinical Trials as Topic; Female; Herpes Zoster; Humans; Immunocompromised Host; Incidence; Infections; Male; Middle Aged; Neoplasms; Opportunistic Infections; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Time Factors; Tuberculosis; Young Adult | 2017 |
Safety of Tofacitinib in the Treatment of Rheumatoid Arthritis in Latin America Compared With the Rest of the World Population.
Topics: Adult; Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Monitoring; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Incidence; Janus Kinase Inhibitors; Latin America; Long Term Adverse Effects; Male; Middle Aged; Patient Safety; Piperidines; Pyrimidines; Pyrroles; Treatment Outcome | 2017 |
Regulatory role of the JAK STAT kinase signalling system on the IL-23/IL-17 cytokine axis in psoriatic arthritis.
Topics: Arthritis, Psoriatic; Humans; Inflammation; Interleukin-17; Interleukin-23; Janus Kinases; Piperidines; Pyrimidines; Pyrroles | 2017 |
Response to: 'Regulatory role of the JAK STAT kinase signalling system on the IL-23/IL-17 cytokine axis in psoriatic arthritis' by Raychaudhuri
Topics: Arthritis, Psoriatic; Humans; Inflammation; Interleukin-17; Interleukin-23; Janus Kinases; Piperidines; Pyrimidines; Pyrroles | 2017 |
Evaluation of JAK3 Biology in Autoimmune Disease Using a Highly Selective, Irreversible JAK3 Inhibitor.
Topics: Animals; Arthritis, Experimental; Autoimmune Diseases; Dose-Response Relationship, Drug; Drug Monitoring; Humans; Isoenzymes; Janus Kinase 1; Janus Kinase 3; Monitoring, Immunologic; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Rats | 2017 |
Sensitivity to PI3K and AKT inhibitors is mediated by divergent molecular mechanisms in subtypes of DLBCL.
Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Animals; Antineoplastic Agents; Apoptosis; Drug Combinations; Drug Screening Assays, Antitumor; Drug Synergism; Gene Expression Regulation, Neoplastic; Humans; Lymphoma, Large B-Cell, Diffuse; Mice; NF-kappa B; Organ Specificity; Oxadiazoles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Piperidines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-myc; PTEN Phosphohydrolase; Pyrazoles; Pyrimidines; Pyrroles; Signal Transduction; Xenograft Model Antitumor Assays | 2017 |
JAK-STAT Signaling Pathways and Inhibitors Affect Reversion of Envelope-Mutated HIV-1.
Topics: Binding Sites; CD4 Antigens; CD4-Positive T-Lymphocytes; env Gene Products, Human Immunodeficiency Virus; HIV Infections; HIV-1; Humans; Interleukin-2; Janus Kinases; Nitriles; Piperidines; Pyrazoles; Pyrimidines; Pyrroles; Pyrrolidines; Signal Transduction; STAT Transcription Factors; Sulfonamides; Tetradecanoylphorbol Acetate; TOR Serine-Threonine Kinases; Virus Internalization; Virus Replication | 2017 |
Recovery of nail dystrophy potential new therapeutic indication of tofacitinib.
Topics: Adult; Alopecia; Female; Humans; Male; Nail Diseases; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Treatment Outcome | 2017 |
Social media for arthritis-related comparative effectiveness and safety research and the impact of direct-to-consumer advertising.
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Comparative Effectiveness Research; Direct-to-Consumer Advertising; Herpes Zoster; Humans; Intestinal Perforation; Natural Language Processing; Piperidines; Pyrimidines; Pyrroles; Social Media | 2017 |
Cost-effectiveness of sequenced treatment of rheumatoid arthritis with targeted immune modulators.
Topics: Abatacept; Adalimumab; Age Factors; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Certolizumab Pegol; Cost-Benefit Analysis; Drug Therapy, Combination; Etanercept; Humans; Infliximab; Models, Economic; Piperidines; Pyrimidines; Pyrroles; Quality-Adjusted Life Years; Severity of Illness Index; Sex Factors; Time Factors; Tumor Necrosis Factor-alpha; United States | 2017 |
Tracking JAKs in spondyloarthritis: rationale and expectations.
Topics: Humans; Motivation; Piperidines; Pyrimidines; Pyrroles; Spondylarthritis; Spondylitis, Ankylosing | 2017 |
Experience with oral tofacitinib in 8 adolescent patients with alopecia universalis.
Topics: Administration, Oral; Adolescent; Alopecia; Child; Dermatologic Agents; Humans; Janus Kinase 1; Piperidines; Pyrimidines; Pyrroles; Treatment Outcome; Young Adult | 2017 |
Treatment of Alopecia Areata With Tofacitinib.
Topics: Adult; Alopecia Areata; Female; Follow-Up Studies; Hair; Humans; Male; Middle Aged; Piperidines; Polyps; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Scalp; Treatment Outcome; Young Adult | 2017 |
Cytokine receptor signaling is required for the survival of ALK- anaplastic large cell lymphoma, even in the presence of JAK1/STAT3 mutations.
Topics: Anaplastic Lymphoma Kinase; Animals; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cytokine Receptor gp130; Cytokines; Humans; Janus Kinase 1; Lymphoma, Large-Cell, Anaplastic; Mice; Nitriles; Phosphorylation; Piperidines; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; Pyrroles; Receptor Protein-Tyrosine Kinases; Receptors, Cytokine; Signal Transduction; STAT3 Transcription Factor; Xenograft Model Antitumor Assays | 2017 |
Janus kinase inhibitors prevent migration of rheumatoid arthritis neutrophils towards interleukin-8, but do not inhibit priming of the respiratory burst or reactive oxygen species production.
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Azetidines; Case-Control Studies; Cell Movement; Cells, Cultured; Female; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interleukin-8; Janus Kinases; Male; Middle Aged; Neutrophils; Piperidines; Protein Kinase Inhibitors; Purines; Pyrazoles; Pyrimidines; Pyrroles; Reactive Oxygen Species; Respiratory Burst; Sulfonamides; Tetradecanoylphorbol Acetate; United Kingdom | 2017 |
Successful targeted treatment of mast cell activation syndrome with tofacitinib.
Topics: Adult; Biomarkers; Female; Humans; Mastocytosis; Middle Aged; Molecular Targeted Therapy; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Symptom Assessment; Treatment Outcome | 2017 |
Facilitation of liver cancer SMCC7721 cell aging by sirtuin 4 via inhibiting JAK2/STAT3 signal pathway.
Topics: Cell Line, Tumor; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p16; Doxorubicin; Humans; Janus Kinase 2; Liver Neoplasms; Mitochondrial Proteins; Piperidines; Pyrimidines; Pyrroles; Signal Transduction; Sirtuins; STAT3 Transcription Factor; Tumor Suppressor Protein p53 | 2017 |
Cytomegalovirus retinitis followed by immune recovery uveitis in an elderly patient with rheumatoid arthritis undergoing administration of methotrexate and tofacitinib combination therapy.
Topics: Aged; Antiviral Agents; Arthritis, Rheumatoid; Cytomegalovirus Retinitis; Ganciclovir; Humans; Immunosuppressive Agents; Intravitreal Injections; Male; Methotrexate; Piperidines; Pyrimidines; Pyrroles; Uveitis | 2017 |
Discontinuation of tofacitinib after achieving low disease activity in patients with rheumatoid arthritis: a multicentre, observational study.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Female; Humans; Male; Middle Aged; Piperidines; Prospective Studies; Pyrimidines; Pyrroles; Time Factors; Treatment Outcome; Withholding Treatment | 2017 |
Tofacitinib attenuates arthritis manifestations and reduces the pathogenic CD4 T cells in adjuvant arthritis rats.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; C-Reactive Protein; CD4-Positive T-Lymphocytes; Foot; Foot Joints; Forelimb; Hindlimb; Interferon-gamma; Interleukin-1beta; Methotrexate; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Rats; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spleen | 2017 |
Efficacy and safety at 24 weeks of daily clinical use of tofacitinib in patients with rheumatoid arthritis.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; Middle Aged; Piperidines; Pyrimidines; Pyrroles | 2017 |
Jak3 deficiency blocks innate lymphoid cell development.
Topics: Animals; Arthritis, Rheumatoid; Bone Marrow Cells; Cell Differentiation; Cell Proliferation; Cells, Cultured; Humans; Immunity, Innate; Interferon-gamma; Janus Kinase 3; Killer Cells, Natural; Mice; Mice, Mutant Strains; Mutation; Phenotype; Piperidines; Pyrimidines; Pyrroles; Severe Combined Immunodeficiency | 2018 |
IBD: Tofacitinib effective in ulcerative colitis.
Topics: Colitis, Ulcerative; Humans; Piperidines; Pyrimidines; Pyrroles | 2017 |
Successful hair regrowth in a Korean patient with alopecia universalis following tofacitinib treatment.
Topics: Adult; Alopecia; Female; Humans; Piperidines; Pyrimidines; Pyrroles; Treatment Outcome | 2017 |
Identification of related substances in tofacitinib citrate by LC-MS techniques for synthetic process optimization.
Topics: Chromatography, Liquid; Drug Stability; Piperidines; Pyrimidines; Pyrroles; Tandem Mass Spectrometry | 2017 |
Improved efficacy of allergen-specific immunotherapy by JAK inhibition in a murine model of allergic asthma.
Topics: Allergens; Animals; Asthma; Bronchoalveolar Lavage Fluid; Cell Differentiation; Cytokines; Desensitization, Immunologic; Disease Models, Animal; Humans; Janus Kinases; Mice; Mice, Inbred C57BL; Ovalbumin; Piperidines; Pyrimidines; Pyrroles | 2017 |
Image Gallery: Treatment of refractory alopecia universalis with oral tofacitinib citrate and adjunct intralesional triamcinolone injections.
Topics: Administration, Oral; Alopecia; Drug Therapy, Combination; Glucocorticoids; Humans; Injections, Intralesional; Male; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Triamcinolone; Young Adult | 2017 |
Tofacitinib ameliorates atherosclerosis and reduces foam cell formation in apoE deficient mice.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Diet, Atherogenic; Dose-Response Relationship, Drug; Foam Cells; Mice; Mice, Inbred C57BL; Mice, Knockout; Piperidines; Pyrimidines; Pyrroles; Structure-Activity Relationship | 2017 |
Topical Janus kinase inhibitors for the treatment of pediatric alopecia areata.
Topics: Administration, Cutaneous; Adolescent; Alopecia Areata; Child, Preschool; Female; Humans; Janus Kinases; Male; Nitriles; Piperidines; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; Pyrroles; Skin Cream | 2017 |
2017 American College of Rheumatology/American Association of Hip and Knee Surgeons Guideline for the Perioperative Management of Antirheumatic Medication in Patients With Rheumatic Diseases Undergoing Elective Total Hip or Total Knee Arthroplasty.
Topics: Antirheumatic Agents; Arthritis, Juvenile; Arthritis, Psoriatic; Arthritis, Rheumatoid; Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Biological Products; Glucocorticoids; Humans; Immunosuppressive Agents; Lupus Erythematosus, Systemic; Orthopedics; Perioperative Care; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Rheumatic Diseases; Rheumatology; Societies, Medical; Spondylitis, Ankylosing; United States | 2017 |
Treating active rheumatoid arthritis with Janus kinase inhibitors.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Janus Kinase Inhibitors; Janus Kinases; Piperidines; Protein Kinase Inhibitors; Pyrroles | 2017 |
Excellent response to tofacitinib treatment in a patient with alopecia universalis.
Topics: Alopecia; Female; Humans; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Young Adult | 2017 |
Tofacitinib restores the inhibition of reverse cholesterol transport induced by inflammation: understanding the lipid paradox associated with rheumatoid arthritis.
Topics: Animals; Arthritis, Rheumatoid; Cholesterol; Diet, High-Fat; Dose-Response Relationship, Drug; Inflammation; Lipids; Macrophages; Male; Piperidines; Pyrimidines; Pyrroles; Rabbits; Structure-Activity Relationship | 2017 |
Reactivation of hepatitis B virus infection in patients with rheumatoid arthritis receiving tofacitinib: a real-world study.
Topics: Adult; Arthritis, Rheumatoid; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Piperidines; Pyrimidines; Pyrroles; Retrospective Studies; Taiwan; Virus Activation | 2018 |
Rheumatoid arthritis: JAK-ing up inadequate RA therapy.
Topics: Adalimumab; Arthritis, Rheumatoid; Double-Blind Method; Humans; Methotrexate; Piperidines; Pyrimidines; Pyrroles | 2017 |
Herpes zoster in psoriasis patients treated with tofacitinib.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Asian People; Biological Products; Etanercept; Female; Herpes Zoster; Hospitalization; Humans; Immunosuppressive Agents; Incidence; Male; Middle Aged; Piperidines; Proportional Hazards Models; Psoriasis; Pyrimidines; Pyrroles; Risk Factors; Young Adult | 2017 |
Inhibitory effect of JAK inhibitor on mechanical stress-induced protease expression by human articular chondrocytes.
Topics: ADAMTS4 Protein; ADAMTS5 Protein; Aggrecans; Cartilage, Articular; Cells, Cultured; Chondrocytes; Collagen Type II; Core Binding Factor Alpha 1 Subunit; Cytokines; Humans; Janus Kinase Inhibitors; Matrix Metalloproteinase 13; Mitogen-Activated Protein Kinases; Piperidines; Pyrimidines; Pyrroles; STAT3 Transcription Factor; Stress, Mechanical; Transcription Factor RelA | 2017 |
A study on the risk of fungal infection with tofacitinib (CP-690550), a novel oral agent for rheumatoid arthritis.
Topics: Administration, Oral; Adult; Animals; Arthritis, Rheumatoid; Candida albicans; Candidiasis; Disease Susceptibility; Female; Humans; Mice, Inbred BALB C; Neutrophil Activation; Neutrophils; Phagocytosis; Piperidines; Pyrimidines; Pyrroles; Risk Factors | 2017 |
GSK2586184, a JAK1 selective inhibitor, in two patients with ulcerative colitis.
Topics: Adult; Azetidines; C-Reactive Protein; Clinical Trials as Topic; Colitis, Ulcerative; Humans; Janus Kinase 1; Leukocyte L1 Antigen Complex; Male; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Severity of Illness Index; Triazoles | 2017 |
Repigmentation in vitiligo using the Janus kinase inhibitor tofacitinib may require concomitant light exposure.
Topics: Adult; Aged; Autoimmunity; Chemokine CXCL10; Chemokine CXCL9; Combined Modality Therapy; Female; Humans; Janus Kinase 1; Janus Kinase 3; Male; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Retrospective Studies; Severity of Illness Index; Skin Pigmentation; Ultraviolet Therapy; Vitiligo | 2017 |
Editorial: Herpes Zoster: Fear the Infection, Value the Solution.
Topics: Arthritis, Rheumatoid; Fear; Herpes Zoster; Humans; Piperidines; Pyrimidines; Pyrroles; Vaccination | 2017 |
Herpes Zoster and Tofacitinib: Clinical Outcomes and the Risk of Concomitant Therapy.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Chloroquine; Clinical Trials as Topic; Databases, Factual; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Glucocorticoids; Herpes Zoster; Humans; Incidence; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Multivariate Analysis; Piperidines; Proportional Hazards Models; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Risk Factors | 2017 |
Efficacy of topical tofacitinib in promoting hair growth in non-scarring alopecia: possible mechanism via VEGF induction.
Topics: Administration, Topical; Alopecia; Animals; Hair; Janus Kinase 3; Male; Mice; Mice, Inbred C57BL; Minoxidil; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Vascular Endothelial Growth Factor A | 2017 |
Rheumatoid arthritis: Reducing the risk of herpes zoster.
Topics: Arthritis, Rheumatoid; Herpes Zoster; Humans; Piperidines; Pyrimidines; Pyrroles; Vaccination | 2017 |
Lymphoma in the Tofacitinib Rheumatoid Arthritis Clinical Development Program.
Topics: Adult; Aged; Arthritis, Rheumatoid; Case-Control Studies; Female; Humans; Janus Kinase 3; Lymphoma; Male; Middle Aged; Piperidines; Pyrimidines; Pyrroles | 2018 |
Design and Synthesis of a Highly Selective JAK3 Inhibitor for the Treatment of Rheumatoid Arthritis.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Disease Progression; Female; Humans; Inhibitory Concentration 50; Janus Kinase 3; Male; Mass Spectrometry; Mice; Mice, Inbred BALB C; Molecular Docking Simulation; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley | 2017 |
Effects of tofacitinib in early arthritis-induced bone loss in an adjuvant-induced arthritis rat model.
Topics: Adjuvants, Immunologic; Animals; Arthritis; Bone and Bones; Bone Remodeling; Bone Resorption; Disease Models, Animal; Female; Osteocalcin; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Rats; Rats, Wistar; Treatment Outcome; X-Ray Microtomography | 2018 |
Prevention of chronic renal allograft rejection by AS2553627, a novel JAK inhibitor, in a rat transplantation model.
Topics: Allografts; Animals; Chronic Disease; Disease Models, Animal; Drug Therapy, Combination; Glomerulosclerosis, Focal Segmental; Graft Rejection; Humans; Interleukin-6; Janus Kinases; Kidney Transplantation; Piperidines; Pyrroles; Rats; Rats, Inbred Lew; Tacrolimus | 2018 |
Oral tofacitinib monotherapy in Korean patients with refractory moderate-to-severe alopecia areata: A case series.
Topics: Administration, Oral; Adolescent; Adult; Alopecia Areata; Female; Humans; Male; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Republic of Korea; Retrospective Studies; Severity of Illness Index; Young Adult | 2017 |
Tofacitinib improves atherosclerosis despite up-regulating serum cholesterol in patients with active rheumatoid arthritis: a cohort study.
Topics: Adult; Aged; Arthritis, Rheumatoid; Atherosclerosis; Carotid Arteries; Carotid Intima-Media Thickness; Cholesterol; Cohort Studies; Drug Administration Schedule; Female; Humans; Intention to Treat Analysis; Male; Methotrexate; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Risk Factors; Single-Blind Method; Surveys and Questionnaires; Ultrasonography; Up-Regulation | 2017 |
Oral tofacitinib: a promising treatment in atopic dermatitis, alopecia areata and vitiligo.
Topics: Adult; Alopecia Areata; Dermatitis, Atopic; Humans; Janus Kinase Inhibitors; Male; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Th2 Cells; Treatment Outcome; Vitiligo | 2017 |
Treatment Persistence and Healthcare Costs Among Patients with Rheumatoid Arthritis Changing Biologics in the USA.
Topics: Abatacept; Adalimumab; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Certolizumab Pegol; Databases, Factual; Etanercept; Female; Humans; Infliximab; Male; Middle Aged; Piperidines; Pyrimidines; Pyrroles; Retrospective Studies; Tumor Necrosis Factor-alpha | 2017 |
NICE issues positive recommendation for XELJANZ®▼(tofacitinib citrate) as a new treatment option for adults with severe rheumatoid arthritis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Approval; Humans; Piperidines; Pyrimidines; Pyrroles; United Kingdom | 2017 |
Cellular and functional actions of tofacitinib related to the pathophysiology of hibernoma development.
Topics: Adipose Tissue, Brown; Animals; Blood Pressure; Cell Proliferation; Female; Heart Rate; Janus Kinase Inhibitors; Lipoma; Male; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Signal Transduction; STAT Transcription Factors; Trans-Activators | 2017 |
T-cell-mediated immune response to pneumococcal conjugate vaccine (PCV-13) and tetanus toxoid vaccine in patients with moderate-to-severe psoriasis during tofacitinib treatment.
Topics: Adult; Aged; Cohort Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Immunity, Cellular; Male; Middle Aged; Piperidines; Pneumococcal Vaccines; Prospective Studies; Protein Kinase Inhibitors; Psoriasis; Pyrimidines; Pyrroles; Sensitivity and Specificity; Severity of Illness Index; T-Lymphocytes; Tetanus Toxoid; Vaccination; Vaccines, Conjugate; Young Adult | 2018 |
Tofacitinib 2% ointment, a topical Janus kinase inhibitor, for the treatment of alopecia areata: A pilot study of 10 patients.
Topics: Adult; Alopecia Areata; Female; Hair; Humans; Male; Middle Aged; Ointments; Pilot Projects; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Young Adult | 2018 |
Successful treatment of moderate-to-severe alopecia areata improves health-related quality of life.
Topics: Adult; Alopecia Areata; Emotions; Female; Humans; Male; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Quality of Life; Severity of Illness Index; Surveys and Questionnaires; Young Adult | 2018 |
LC-ESI-MS/MS determination of defactinib, a novel FAK inhibitor in mice plasma and its application to a pharmacokinetic study in mice.
Topics: Animals; Area Under Curve; Benzamides; Carbon Isotopes; Chromatography, High Pressure Liquid; Drug Stability; Focal Adhesion Kinase 1; Limit of Detection; Liquid-Liquid Extraction; Male; Mice; Mice, Inbred BALB C; Nitrogen Isotopes; Piperidines; Protein Kinase Inhibitors; Pyrazines; Pyrimidines; Pyrroles; Reference Standards; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Sulfonamides; Tandem Mass Spectrometry | 2018 |
The combination of CHK1 inhibitor with G-CSF overrides cytarabine resistance in human acute myeloid leukemia.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Checkpoint Kinase 1; Cytarabine; Drug Resistance, Neoplasm; Female; Granulocyte Colony-Stimulating Factor; Hematopoiesis; HL-60 Cells; Humans; Leukemia, Myeloid, Acute; Male; Mice; Mice, Inbred NOD; Mice, SCID; Mutation; Piperidines; Protein Kinase Inhibitors; Pyridines; Pyrroles; U937 Cells; Xenograft Model Antitumor Assays | 2017 |
Validation of the Itch Severity Item as a Measurement Tool for Pruritus in Patients with Psoriasis: Results from a Phase 3 Tofacitinib Program.
Topics: Antipruritics; Clinical Trials, Phase III as Topic; Humans; Piperidines; Predictive Value of Tests; Pruritus; Psoriasis; Psychometrics; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Remission Induction; Reproducibility of Results; Severity of Illness Index; Surveys and Questionnaires; Time Factors; Treatment Outcome | 2018 |
Inhibition of JAK-STAT Signaling Suppresses Pathogenic Immune Responses in Medium and Large Vessel Vasculitis.
Topics: Adaptive Immunity; Adoptive Transfer; Aged; Animals; Cell Proliferation; Cytokines; Disease Models, Animal; Female; Gene Expression Regulation; Giant Cell Arteritis; Heterografts; Humans; Immunity, Innate; Immunologic Memory; Janus Kinase 1; Janus Kinase 3; Janus Kinase Inhibitors; Janus Kinases; Lymphocyte Activation; Male; Mice, Inbred NOD; Mice, SCID; Mice, Transgenic; Middle Aged; Neointima; Neovascularization, Pathologic; Piperidines; Pyrimidines; Pyrroles; Signal Transduction; STAT Transcription Factors; T-Lymphocytes; Temporal Arteries; Vascular Remodeling | 2018 |
Spondyloarthropathies: Tofacitinib shows promise in PsA trials.
Topics: Arthritis, Psoriatic; Humans; Piperidines; Pyrimidines; Pyrroles; Spondylarthropathies | 2017 |
Epidemiology: Arthritis more common than expected.
Topics: Arthritis; Arthritis, Psoriatic; Humans; Piperidines; Pyrimidines; Pyrroles | 2017 |
Tofacitinib rapidly ameliorated polyarthropathy in a patient with systemic sclerosis.
Topics: Arthritis; Female; Humans; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Scleroderma, Systemic | 2018 |
Outcomes after rheumatoid arthritis patients complete their participation in a long-term observational study with tofacitinib combined with methotrexate: practical and ethical implications in vulnerable populations after tofacitinib discontinuation.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Disability Evaluation; Disease Progression; Drug Therapy, Combination; Ethics, Research; Female; Humans; Male; Methotrexate; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Recurrence; Remission Induction; Research Design; Research Subjects; Time Factors; Treatment Outcome; Vulnerable Populations | 2018 |
Novel mechanisms to inhibit HIV reservoir seeding using Jak inhibitors.
Topics: Anti-HIV Agents; CD4-Positive T-Lymphocytes; Cells, Cultured; HIV Infections; HIV-1; Humans; Janus Kinase Inhibitors; Nitriles; Piperidines; Pyrazoles; Pyrimidines; Pyrroles; Virus Latency; Virus Replication | 2017 |
[Inhibitory effect and mechanism of tofacitinib on the secretion of cytokines by T cells in human peripheral blood].
Topics: CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cells, Cultured; Cytokines; Humans; Interferon-gamma; Interleukin-2 Receptor alpha Subunit; Lymphocyte Activation; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; STAT1 Transcription Factor; STAT3 Transcription Factor; STAT4 Transcription Factor; Tumor Necrosis Factor-alpha | 2017 |
JAK/STAT-1 Signaling Is Required for Reserve Intestinal Stem Cell Activation during Intestinal Regeneration Following Acute Inflammation.
Topics: Acute Disease; Animals; Apoptosis; Cytokines; Enteritis; Inflammation; Intestinal Mucosa; Intestine, Small; Janus Kinases; Mice; Mice, Transgenic; Piperidines; Pyrimidines; Pyrroles; Regeneration; Signal Transduction; STAT1 Transcription Factor; Stem Cells | 2018 |
A Case Series on Patients on Tofacitinib in Combination With a Biologic.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Drug Monitoring; Drug Therapy, Combination; Female; Humans; Immunologic Factors; Janus Kinase 3; Male; Middle Aged; Piperidines; Pyrimidines; Pyrroles; Severity of Illness Index; Treatment Outcome | 2018 |
Reply to: "Tofacitinib for the treatment of severe alopecia areata and variants".
Topics: Alopecia Areata; Humans; Piperidines; Pyrimidines; Pyrroles | 2018 |
Editorial: tofacitinib and biologics for moderate-to-severe ulcerative colitis-what is best in class? Authors' reply.
Topics: Biological Products; Biological Therapy; Colitis, Ulcerative; Humans; Piperidines; Pyrimidines; Pyrroles | 2018 |
Editorial: tofacitinib and biologics for moderate-to-severe ulcerative colitis-what is best in class?
Topics: Biological Products; Biological Therapy; Colitis, Ulcerative; Humans; Piperidines; Pyrimidines; Pyrroles | 2018 |
Bone remodelling: locus minori or unappreciated potential of tofacitinib?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Bone Remodeling; Double-Blind Method; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Treatment Outcome | 2018 |
Rapid Repigmentation of Vitiligo Using Tofacitinib Plus Low-Dose, Narrowband UV-B Phototherapy.
Topics: Adult; Combined Modality Therapy; Female; Humans; Male; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Skin Pigmentation; Ultraviolet Therapy; Vitiligo | 2018 |
Safety signal detection and evaluation in clinical development programs: A case study of tofacitinib.
Topics: Adverse Drug Reaction Reporting Systems; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Clinical Trials as Topic; Feasibility Studies; Female; Humans; Incidence; Janus Kinase Inhibitors; Japan; Male; Middle Aged; Pancreatic Neoplasms; Pharmacovigilance; Piperidines; Product Surveillance, Postmarketing; Pyrimidines; Pyrroles | 2018 |
[Current and upcoming treatments of adult atopic dermatitis].
Topics: Adult; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Azathioprine; Boron Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cyclosporine; Dermatitis, Atopic; Dermatologic Agents; Glucocorticoids; Humans; Methotrexate; Mycophenolic Acid; Piperidines; Pyrimidines; Pyrroles; Thalidomide; Ustekinumab | 2017 |
The use of JAK inhibitors in the treatment of progressive systemic sclerosis.
Topics: Adult; Humans; Janus Kinase Inhibitors; Male; Piperidines; Pyrimidines; Pyrroles; Scleroderma, Systemic | 2018 |
Immunologic effects of chronic administration of tofacitinib, a Janus kinase inhibitor, in cynomolgus monkeys and rats - Comparison of juvenile and adult responses.
Topics: Administration, Oral; Aging; Animals; Antigens; Erythrocyte Count; Female; Hematocrit; Hemocyanins; Hemoglobins; Janus Kinase Inhibitors; Leukocyte Count; Leukocytes; Lymphoma, B-Cell; Macaca fascicularis; Male; Organ Size; Piperidines; Pyrimidines; Pyrroles; Rats, Sprague-Dawley; Spleen; Thymus Gland; Toxicity Tests, Chronic | 2018 |
Pharmacological inhibition of JAK3 enhances the antitumor activity of imatinib in human chronic myeloid leukemia.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Humans; Imatinib Mesylate; Janus Kinase 3; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Neoplastic Stem Cells; Piperidines; Pyrimidines; Pyrroles; Signal Transduction | 2018 |
Tofacitinib for Psoriatic Arthritis.
Topics: Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Humans; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Treatment Outcome | 2018 |
Tofacitinib for Psoriatic Arthritis.
Topics: Arthritis, Psoriatic; Piperidines; Pyrimidines; Pyrroles | 2018 |
Herpes zoster as a cause of atypical chronic ulcerations associated with tofacitinib.
Topics: Arthritis, Rheumatoid; Chronic Disease; Female; Herpes Zoster; Humans; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Skin; Skin Ulcer | 2018 |
The anti-inflammatory effect of topical tofacitinib on immediate and late-phase cutaneous allergic reactions in dogs: a placebo-controlled pilot study.
Topics: Animals; Anti-Inflammatory Agents; Dermatitis, Atopic; Dog Diseases; Dogs; Hypersensitivity, Delayed; Hypersensitivity, Immediate; Inflammation; Pilot Projects; Piperidines; Pyrimidines; Pyrroles | 2018 |
MALDI imaging facilitates new topical drug development process by determining quantitative skin distribution profiles.
Topics: Acetamides; Administration, Topical; Aminopyridines; Benzamides; Cyclopropanes; Drug Discovery; Humans; Nitriles; Phosphodiesterase 4 Inhibitors; Piperidines; Protein Kinase Inhibitors; Pyrazoles; Pyridines; Pyrimidines; Pyrroles; Skin; Skin Absorption; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2018 |
Effectiveness and safety of tofacitinib in rheumatoid arthritis: a cohort study.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Female; Humans; Infections; Male; Methotrexate; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Retrospective Studies; Treatment Outcome | 2018 |
Stattic inhibits RANKL-mediated osteoclastogenesis by suppressing activation of STAT3 and NF-κB pathways.
Topics: Animals; Arthritis, Rheumatoid; Bone Resorption; Cyclic S-Oxides; Gene Expression Regulation; Genes, fos; Humans; Janus Kinases; Macrophages; Mice; NF-kappa B; NFATC Transcription Factors; Osteogenesis; Piperidines; Pyrimidines; Pyrroles; RANK Ligand; RAW 264.7 Cells; Signal Transduction; STAT3 Transcription Factor | 2018 |
Tofacitinib Halts Progression of Graft Dysfunction in a Rat Model of Mixed Cellular and Humoral Rejection.
Topics: Animals; Chronic Disease; Complement C4b; Disease Models, Animal; Disease Progression; Graft Rejection; Graft Survival; Humans; Immunity, Cellular; Immunity, Humoral; Immunosuppressive Agents; Janus Kinase 3; Kidney; Kidney Transplantation; Male; Peptide Fragments; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Rats; Rats, Inbred F344; Rats, Inbred Lew; Signal Transduction; Treatment Outcome | 2018 |
Repurposing tofacitinib as an anti-myeloma therapeutic to reverse growth-promoting effects of the bone marrow microenvironment.
Topics: Animals; Bone Marrow; Cell Communication; Disease Models, Animal; Drug Repositioning; Humans; Janus Kinases; Mesenchymal Stem Cells; Mice; Multiple Myeloma; Phosphoproteins; Piperidines; Plasma Cells; Protein Kinase Inhibitors; Proteome; Proteomics; Pyrimidines; Pyrroles; Signal Transduction; STAT Transcription Factors; Tumor Microenvironment; Xenograft Model Antitumor Assays | 2018 |
Elderly-Onset Varicella Pneumonia in a Patient With Rheumatoid Arthritis Treated With Tofacitinib.
Topics: Aged; Arthritis, Rheumatoid; Chickenpox; Female; Herpesvirus 3, Human; Humans; Piperidines; Pneumonia, Viral; Protein Kinase Inhibitors; Pyrimidines; Pyrroles | 2018 |
Nail involvement in patients with moderate-to-severe alopecia areata treated with oral tofacitinib.
Topics: Administration, Oral; Adult; Alopecia Areata; Female; Humans; Male; Middle Aged; Nail Diseases; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Retrospective Studies | 2018 |
Cost-Effectiveness of Different Strategies for the Treatment of Moderate-to-Severe Ulcerative Colitis.
Topics: Adult; Antibodies, Monoclonal, Humanized; China; Colitis, Ulcerative; Cost-Benefit Analysis; Gastrointestinal Agents; Humans; Immunosuppressive Agents; Piperidines; Prognosis; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Quality-Adjusted Life Years; Severity of Illness Index; Tumor Necrosis Factor-alpha; United Kingdom | 2018 |
Factors associated with physicians' prescriptions for rheumatoid arthritis drugs not filled by patients.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Logistic Models; Male; Methotrexate; Middle Aged; Patient Compliance; Physicians; Piperidines; Prescriptions; Pyrimidines; Pyrroles; Risk Factors | 2018 |
Tofacitinib in steroid-dependent relapsing polychondritis.
Topics: Biological Products; Humans; Piperidines; Polychondritis, Relapsing; Pyrimidines; Pyrroles | 2019 |
Tofacitinib Represses the Janus Kinase-Signal Transducer and Activators of Transcription Signalling Pathway in Keratinocytes.
Topics: Case-Control Studies; Cells, Cultured; Down-Regulation; Early Growth Response Protein 1; Humans; Interleukin-22; Interleukins; Janus Kinases; Keratinocytes; Piperidines; Protein Kinase Inhibitors; Psoriasis; Pyrimidines; Pyrroles; S100 Calcium Binding Protein A7; Signal Transduction; STAT Transcription Factors | 2018 |
Topical 2% tofacitinib for children with alopecia areata, alopecia totalis, and alopecia universalis.
Topics: Administration, Topical; Adolescent; Alopecia; Alopecia Areata; Child; Child, Preschool; Cohort Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Hair; Humans; Male; Pediatrics; Piperidines; Pyrimidines; Pyrroles; Sampling Studies; Treatment Outcome | 2018 |
JAK/STAT Blockade Alters Synovial Bioenergetics, Mitochondrial Function, and Proinflammatory Mediators in Rheumatoid Arthritis.
Topics: Arthritis, Rheumatoid; Cells, Cultured; Energy Metabolism; Fibroblasts; Humans; Inflammation Mediators; Janus Kinases; Mitochondria; Oncostatin M; Phosphorylation; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Signal Transduction; STAT Transcription Factors; Synovial Membrane | 2018 |
Pharmacokinetic Characteristics of Tofacitinib in Adult Patients With Moderate to Severe Chronic Plaque Psoriasis.
Topics: Adult; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Dose-Response Relationship, Drug; Female; Humans; Inactivation, Metabolic; Janus Kinase Inhibitors; Male; Models, Biological; Piperidines; Psoriasis; Pyrimidines; Pyrroles; Severity of Illness Index; Tissue Distribution | 2018 |
Treatment of halo naevus with the topical Janus kinase inhibitor tofacitinib 1.5.
Topics: Administration, Topical; Back; Child; Dermatologic Agents; Humans; Lip Neoplasms; Male; Nevus, Halo; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Skin Neoplasms | 2018 |
Discriminating phenotypic signatures identified for tocilizumab, adalimumab, and tofacitinib monotherapy and their combinations with methotrexate.
Topics: Adalimumab; Antibodies, Monoclonal, Humanized; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Inflammation; Methotrexate; Phenotype; Piperidines; Pyrimidines; Pyrroles; Receptors, Interleukin-6; Signal Transduction | 2018 |
An Economic Evaluation of Tofacitinib Treatment in Rheumatoid Arthritis After Methotrexate or After 1 or 2 TNF Inhibitors from a U.S. Payer Perspective.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Clinical Decision-Making; Cost Savings; Cost-Benefit Analysis; Decision Support Techniques; Decision Trees; Drug Costs; Drug Substitution; Humans; Methotrexate; Models, Economic; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Remission Induction; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha; United States | 2018 |
Case report: successful treatment of refractory SAPHO syndrome with the JAK inhibitor tofacitinib.
Topics: Acquired Hyperostosis Syndrome; Adult; Antirheumatic Agents; Autoimmunity; Bone and Bones; Drug Resistance, Multiple; Drug Therapy, Combination; Female; Humans; Immunologic Tests; Janus Kinase Inhibitors; Methotrexate; Piperidines; Pyrimidines; Pyrroles; Tomography, Emission-Computed; Treatment Outcome | 2018 |
Development of a Janus Kinase Inhibitor Prodrug for the Treatment of Rheumatoid Arthritis.
Topics: Acrylamides; Administration, Oral; Animals; Ankle Joint; Arthritis, Experimental; Arthritis, Rheumatoid; Cells, Cultured; Janus Kinase Inhibitors; Janus Kinases; Macrophages; Male; Mice, Inbred C57BL; Piperidines; Primary Cell Culture; Prodrugs; Pyrimidines; Pyrroles; Rats; Rats, Inbred Lew; Signal Transduction; STAT6 Transcription Factor; Tissue Distribution; Treatment Outcome; X-Ray Microtomography | 2018 |
Comparison of topical tofacitinib and 0.1% hypochlorous acid in a murine atopic dermatitis model.
Topics: Administration, Topical; Animals; Cells, Cultured; Cytokines; Dermatitis, Atopic; Disease Models, Animal; Female; Ganglia, Spinal; Hypochlorous Acid; Immunoglobulin E; Mice; Neurons; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Skin | 2018 |
Modelling the cost-effectiveness of tofacitinib for the treatment of rheumatoid arthritis in the United States.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cost Savings; Cost-Benefit Analysis; Humans; Models, Economic; Piperidines; Pyrimidines; Pyrroles; Quality of Life; Treatment Outcome; United States | 2018 |
Outcomes of Pregnancies With Maternal/Paternal Exposure in the Tofacitinib Safety Databases for Ulcerative Colitis.
Topics: Adult; Colitis, Ulcerative; Databases, Factual; Female; Humans; Infant, Newborn; Janus Kinase Inhibitors; Male; Maternal Exposure; Paternal Exposure; Piperidines; Pregnancy; Pregnancy Outcome; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Young Adult | 2018 |
Tofacitinib Induction Therapy Reduces Symptoms Within 3 Days for Patients With Ulcerative Colitis.
Topics: Adult; Clinical Trials, Phase III as Topic; Colitis, Ulcerative; Female; Gastrointestinal Agents; Humans; Induction Chemotherapy; Male; Middle Aged; Piperidines; Placebos; Pyrimidines; Pyrroles; Treatment Outcome | 2019 |
Calcification Induced by Type I Interferon in Human Aortic Valve Interstitial Cells Is Larger in Males and Blunted by a Janus Kinase Inhibitor.
Topics: Aortic Valve; Aortic Valve Stenosis; Apoptosis; Bone Morphogenetic Protein 2; Calcinosis; Cell Differentiation; Cells, Cultured; Cytokines; Female; Humans; Interferon Type I; Janus Kinase Inhibitors; Lipopolysaccharides; Male; NF-kappa B; Osteoblasts; Piperidines; Proto-Oncogene Proteins c-akt; Pyrimidines; Pyrroles; Sex Factors; Signal Transduction; STAT Transcription Factors; Toll-Like Receptor 4 | 2018 |
Tofacitinib and Risk of Peripheral Neuropathy? Experience of 2 Cases in Patients With Rheumatoid Arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Peripheral Nervous System Diseases; Piperidines; Pyrimidines; Pyrroles; Treatment Outcome | 2021 |
Tofacitinib and TPCA-1 exert chondroprotective effects on extracellular matrix turnover in bovine articular cartilage ex vivo.
Topics: Amides; Animals; Cartilage, Articular; Cattle; Chondrocytes; Collagen Type II; Extracellular Matrix Proteins; Imidazoles; Osteoarthritis; Oxazines; Piperidines; Proteoglycans; Pyridines; Pyrimidines; Pyrroles; Thiophenes | 2019 |
Tofacitinib for refractory interstitial lung diseases in anti-melanoma differentiation-associated 5 gene antibody-positive dermatomyositis.
Topics: Adult; Aged; Dermatomyositis; Drug Therapy, Combination; Female; Ferritins; Glucocorticoids; Humans; Interferon-Induced Helicase, IFIH1; Lung; Lung Diseases, Interstitial; Male; Middle Aged; Piperidines; Prognosis; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Survival Rate; Treatment Outcome | 2018 |
Jakinibs for the treatment of immune dysregulation in patients with gain-of-function signal transducer and activator of transcription 1 (STAT1) or STAT3 mutations.
Topics: Adolescent; Adult; Child; Female; Gain of Function Mutation; Humans; Immunologic Deficiency Syndromes; Janus Kinases; Male; Nitriles; Piperidines; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; Pyrroles; STAT1 Transcription Factor; STAT3 Transcription Factor; Treatment Outcome | 2018 |
Combination Therapy With Vedolizumab and Tofacitinib in a Patient With Ulcerative Colitis and Spondyloarthropathy.
Topics: Antibodies, Monoclonal, Humanized; Biological Products; Colitis, Ulcerative; Humans; Piperidines; Pyrimidines; Pyrroles; Spondylarthropathies | 2019 |
Tofacitinib for psoriatic arthritis (PsA) is now approved by the European Commission.
Topics: Arthritis, Psoriatic; Drug Approval; Europe; Humans; Janus Kinase 3; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles | 2018 |
First Oral Drug for Moderate-To-Severe Ulcerative Colitis.
Topics: Colitis, Ulcerative; Drug Approval; Humans; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles | 2018 |
Tofacitinib inhibits granulocyte-macrophage colony-stimulating factor-induced NLRP3 inflammasome activation in human neutrophils.
Topics: Caspase 1; Cells, Cultured; Gene Expression; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Inflammasomes; Interleukin-1beta; Neutrophils; NLR Family, Pyrin Domain-Containing 3 Protein; Piperidines; Pyrimidines; Pyrroles | 2018 |
Comments on the article "Effectiveness and safety of tofacitinib in rheumatoid arthritis: a cohort study".
Topics: Arthritis, Rheumatoid; Cohort Studies; Humans; Piperidines; Pyrimidines; Pyrroles | 2018 |
Benefit-risk profile of tofacitinib in patients with moderate-to-severe chronic plaque psoriasis: pooled analysis across six clinical trials.
Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Chronic Disease; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Piperidines; Protein Kinase Inhibitors; Psoriasis; Pyrimidines; Pyrroles; Quality of Life; Randomized Controlled Trials as Topic; Risk Assessment; Severity of Illness Index; Young Adult | 2019 |
Determination of Tofacitinib in Mice Whole Blood on Dried Blood Spots Using LC-ESI-MS/MS: Application to Pharmacokinetic Study in Mice.
Topics: Administration, Oral; Animals; Chromatography, High Pressure Liquid; Dried Blood Spot Testing; Drug Stability; Injections, Intravenous; Janus Kinase 3; Male; Mice; Models, Animal; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2019 |
Tofacitinib for the treatment of alopecia areata in preadolescent children.
Topics: Administration, Oral; Age Factors; Alopecia Areata; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Janus Kinase Inhibitors; Male; Piperidines; Prospective Studies; Pyrimidines; Pyrroles; Quality of Life; Risk Assessment; Sampling Studies; Treatment Outcome | 2019 |
Ruxolitinib for the treatment of severe alopecia areata.
Topics: Adolescent; Adult; Alopecia Areata; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Hair; Humans; Male; Middle Aged; Nitriles; Patient Satisfaction; Piperidines; Pyrazoles; Pyrimidines; Pyrroles; Retrospective Studies; Sampling Studies; Severity of Illness Index; Treatment Outcome; Young Adult | 2019 |
Replacement of mycophenolate mofetil with a JAK inhibitor, AS2553627, in combination with low-dose tacrolimus, for renal allograft rejection in non-human primates.
Topics: Animals; Graft Rejection; Immunosuppressive Agents; Kidney Transplantation; Lymphocyte Activation; Macaca fascicularis; Male; Mycophenolic Acid; Piperidines; Pyrroles; Tacrolimus; Transplantation, Homologous | 2018 |
Therapeutic synergy between contact dermatitis from a wig-fixing device and tofacitinib on alopecia areata.
Topics: Adult; Alopecia Areata; Dermatitis, Contact; Hair; Humans; Male; Piperidines; Pyrimidines; Pyrroles; Silicone Gels; Treatment Outcome | 2019 |
Tofacitinib as the potent treatment for refractory pemphigus: A possible alternative treatment for pemphigus.
Topics: Cytokines; Humans; Janus Kinase 1; Janus Kinase 2; Janus Kinase 3; Janus Kinases; Pemphigus; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Signal Transduction; Th2 Cells | 2018 |
CB1 receptors in the paraventricular nucleus of the hypothalamus modulate the release of 5-HT and GABA to stimulate food intake in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Arachidonic Acids; Cyproheptadine; Drug Interactions; Eating; gamma-Aminobutyric Acid; Male; Microinjections; Paraventricular Hypothalamic Nucleus; Piperazines; Piperidines; Piperidones; Pyrazoles; Pyridines; Pyrroles; Rats; Receptor, Cannabinoid, CB1; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spiro Compounds; Tritium | 2018 |
Tofacitinib for the treatment of lichen planopilaris: A case series.
Topics: Administration, Oral; Adult; Aged; Alopecia; Dermatologic Agents; Drug Administration Schedule; Female; Humans; Janus Kinase Inhibitors; Lichen Planus; Male; Middle Aged; Piperidines; Pyrimidines; Pyrroles; Remission Induction; Retrospective Studies; Scalp; Scalp Dermatoses; Skin; Time Factors; Treatment Outcome | 2018 |
Comparison of the Treatment Outcome of Oral Tofacitinib with Other Conventional Therapies in Refractory Alopecia Totalis and Universalis: A Retrospective Study.
Topics: Administration, Oral; Adolescent; Adult; Alopecia; Cyclopropanes; Cyclosporine; Female; Humans; Immunosuppressive Agents; Janus Kinase Inhibitors; Male; Middle Aged; Piperidines; Pyrimidines; Pyrroles; Retrospective Studies; Steroids; Time Factors; Treatment Outcome; Young Adult | 2019 |
High-throughput T cell receptor sequencing identifies clonally expanded CD8+ T cell populations in alopecia areata.
Topics: Adolescent; Adult; Alopecia Areata; Animals; Autoimmune Diseases; CD8-Positive T-Lymphocytes; Disease Models, Animal; Female; Follow-Up Studies; Hair Follicle; High-Throughput Nucleotide Sequencing; Humans; Lymph Nodes; Male; Mice; Mice, Inbred C3H; Middle Aged; NK Cell Lectin-Like Receptor Subfamily K; Pilot Projects; Piperidines; Pyrimidines; Pyrroles; Receptors, Antigen, T-Cell; Scalp; Treatment Outcome; Young Adult | 2018 |
Effect of Janus kinase inhibition by tofacitinib on body composition and glucose metabolism.
Topics: Adiposity; Adult; Aged; Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Body Composition; Diet, High-Fat; Female; Glucose; Humans; Janus Kinase Inhibitors; Lipolysis; Mice; Mice, Inbred C57BL; Middle Aged; Piperidines; Pyrimidines; Pyrroles; Weight Gain | 2018 |
Effect of tofacitinib on the expression of noggin/BMP-4 and hair growth stimulation in mice.
Topics: Animals; Bone Morphogenetic Protein 4; Carrier Proteins; Hair; Hair Follicle; Male; Mice; Mice, Inbred C57BL; Minoxidil; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Skin Physiological Phenomena; Vasodilator Agents | 2018 |
Risk for Herpes Zoster in Tofacitinib-Treated Rheumatoid Arthritis Patients With and Without Concomitant Methotrexate and Glucocorticoids.
Topics: Aged; Arthritis, Rheumatoid; Databases, Factual; Drug Therapy, Combination; Female; Follow-Up Studies; Glucocorticoids; Herpes Zoster; Humans; Incidence; Janus Kinase Inhibitors; Male; Medicare; Methotrexate; Middle Aged; Multivariate Analysis; Piperidines; Pyrimidines; Pyrroles; Risk Assessment; Time Factors; United States | 2019 |
Long-term safety data for tofacitinib, an oral Janus kinase inhibitor, for the treatment for psoriasis.
Topics: Humans; Janus Kinase Inhibitors; Piperidines; Psoriasis; Pyrimidines; Pyrroles | 2018 |
An Immune Suppression-associated EBV-positive Anaplastic Large Cell Lymphoma With a BRAF V600E Mutation.
Topics: Aged; Arthritis, Rheumatoid; Epstein-Barr Virus Infections; Humans; Immunocompromised Host; Lymphoma, Large-Cell, Anaplastic; Male; Mutation; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Pyrimidines; Pyrroles | 2019 |
Targeting Upstream Kinases of STAT3 in Human Medulloblastoma Cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Movement; Cell Proliferation; Cerebellar Neoplasms; Cisplatin; Dasatinib; Drug Synergism; Humans; Medulloblastoma; Nitriles; Piperidines; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; Pyrroles; src-Family Kinases; STAT3 Transcription Factor; Tumor Cells, Cultured | 2019 |
JAK1/3 inhibition preserves epidermal morphology in full-thickness 3D skin models of atopic dermatitis and psoriasis.
Topics: Cell Proliferation; Computer Simulation; Dermatitis, Atopic; Filaggrin Proteins; Humans; Imaging, Three-Dimensional; Intermediate Filament Proteins; Janus Kinase 1; Keratinocytes; Piperidines; Psoriasis; Pyrimidines; Pyrroles; Sensitivity and Specificity; STAT6 Transcription Factor | 2019 |
First Reported Case of Pulmonary Arterial Hypertension Secondary to Tofacitinib Treatment for Undifferentiated Arthritis.
Topics: Antirheumatic Agents; Arthritis; Humans; Piperidines; Pulmonary Arterial Hypertension; Pyrimidines; Pyrroles; Treatment Outcome | 2021 |
Dr. Charles-Schoeman and E. Bananis Reply.
Topics: Arthritis, Rheumatoid; Glucocorticoids; Humans; Piperidines; Pyrimidines; Pyrroles | 2018 |
Effects of Co-medication with Glucocorticoids in Biologics Trials.
Topics: Arthritis, Rheumatoid; Biological Products; Glucocorticoids; Humans; Piperidines; Pyrimidines; Pyrroles | 2018 |
Tofacitinib for the Treatment of Pyoderma Gangrenosum.
Topics: Adult; Female; Histocytochemistry; Humans; Immunohistochemistry; Immunologic Factors; Male; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyoderma Gangrenosum; Pyrimidines; Pyrroles; Skin; Treatment Outcome; Young Adult | 2019 |
Decrease in 14-3-3η protein levels is correlated with improvement in disease activity in patients with rheumatoid arthritis treated with Tofacitinib.
Topics: 14-3-3 Proteins; Adult; Arthritis, Rheumatoid; Biomarkers; Cohort Studies; Female; Humans; Male; Middle Aged; Piperidines; Prognosis; Protein Kinase Inhibitors; Pyrimidines; Pyrroles | 2019 |
Evaluation of the Short-, Mid-, and Long-Term Effects of Tofacitinib on Lymphocytes in Patients With Rheumatoid Arthritis.
Topics: Arthritis, Rheumatoid; B-Lymphocytes; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Humans; Incidence; Infections; Janus Kinase Inhibitors; Killer Cells, Natural; Lymphocyte Count; Piperidines; Pyrimidines; Pyrroles; T-Lymphocyte Subsets; T-Lymphocytes; Time Factors | 2019 |
Efficacy of Induction Therapy With High-Intensity Tofacitinib in 4 Patients With Acute Severe Ulcerative Colitis.
Topics: Adult; Animals; Colitis, Ulcerative; Female; Hospitals; Humans; Immunologic Factors; Induction Chemotherapy; Male; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Treatment Outcome; Young Adult | 2019 |
Antipruritic Effects of Janus Kinase Inhibitor Tofacitinib in a Mouse Model of Psoriasis.
Topics: Animals; Antipruritics; Behavior, Animal; Disease Models, Animal; Imiquimod; Interleukin-22; Interleukin-23; Interleukins; Janus Kinase Inhibitors; Male; Mice, Inbred C57BL; Nerve Fibers; Piperidines; Pruritus; Psoriasis; Pyrimidines; Pyrroles; Skin | 2019 |
Special Article: 2018 American College of Rheumatology/National Psoriasis Foundation Guideline for the Treatment of Psoriatic Arthritis.
Topics: Abatacept; Adalimumab; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Psoriatic; Comorbidity; Diabetes Mellitus; Enthesopathy; Etanercept; Evidence-Based Medicine; Exercise; Glucocorticoids; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Infliximab; Interleukin-12; Interleukin-17; Interleukin-23; Occupational Therapy; Physical Therapy Modalities; Piperidines; Pyrimidines; Pyrroles; Rheumatology; Smoking Cessation; Societies, Medical; Spondylitis; Tumor Necrosis Factor-alpha; Ustekinumab; Weight Loss | 2019 |
Response to tofacitinib therapy of eyebrows and eyelashes in alopecia areata.
Topics: Administration, Topical; Adult; Alopecia Areata; Cohort Studies; Eyebrows; Eyelashes; Female; Follow-Up Studies; Humans; Male; Middle Aged; Piperidines; Pyrimidines; Pyrroles; Retrospective Studies; Risk Assessment; Treatment Outcome; Young Adult | 2019 |
Rebound effect associated with JAK inhibitor use in the treatment of alopecia areata.
Topics: Adult; Alopecia Areata; Female; Humans; Janus Kinases; Middle Aged; Nitriles; Piperidines; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; Pyrroles; Recurrence; Withholding Treatment | 2019 |
Tofacitinib for familial Mediterranean fever: a new alternative therapy?
Topics: Adolescent; Familial Mediterranean Fever; Humans; Male; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Remission Induction; Treatment Outcome | 2019 |
Comparative Risk of Venous Thromboembolism in Rheumatoid Arthritis Patients Receiving Tofacitinib Versus Those Receiving Tumor Necrosis Factor Inhibitors: An Observational Cohort Study.
Topics: Adult; Aged; Arthritis, Rheumatoid; Cohort Studies; Databases, Factual; Female; Humans; Incidence; Janus Kinase Inhibitors; Male; Middle Aged; Piperidines; Proportional Hazards Models; Pulmonary Embolism; Pyrimidines; Pyrroles; Tumor Necrosis Factor Inhibitors; Venous Thromboembolism; Venous Thrombosis | 2019 |
Tofacitinib Treatment and Molecular Analysis of Cutaneous Sarcoidosis.
Topics: Female; Humans; Immunohistochemistry; Janus Kinases; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Remission Induction; Sarcoidosis; Sarcoidosis, Pulmonary; Sequence Analysis, RNA; Signal Transduction; Skin; Skin Diseases; STAT Transcription Factors | 2018 |
Tofacitinib: a new oral Janus kinase inhibitor for psoriasis.
Topics: Humans; Janus Kinase Inhibitors; Piperidines; Psoriasis; Pyrimidines; Pyrroles | 2019 |
Using Number Needed to Harm to Put the Risk of Herpes Zoster From Tofacitinib in Perspective.
Topics: Herpes Zoster; Herpesvirus 3, Human; Humans; Incidence; Inflammatory Bowel Diseases; Piperidines; Prognosis; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; United States | 2019 |
Comparisons of hepatitis C viral replication in patients with rheumatoid arthritis receiving tocilizumab, abatacept and tofacitinib therapy.
Topics: Abatacept; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Male; Middle Aged; Piperidines; Prospective Studies; Pyrimidines; Pyrroles; Virus Replication | 2019 |
Management of refractory cutaneous dermatomyositis: potential role of Janus kinase inhibition with tofacitinib.
Topics: Adult; Aged; Dermatomyositis; Female; Humans; Immunosuppressive Agents; Janus Kinase Inhibitors; Male; Middle Aged; Piperidines; Pyrimidines; Pyrroles; Retreatment; Treatment Outcome | 2019 |
Tofacitinib: A Jak of All Trades.
Topics: Humans; Piperidines; Pyoderma Gangrenosum; Pyrimidines; Pyrroles | 2019 |
Tofacitinib therapy for children with severe alopecia areata.
Topics: Alopecia; Alopecia Areata; Child, Preschool; Female; Humans; Male; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Severity of Illness Index | 2019 |
2017 recommendations of the Brazilian Society of Rheumatology for the pharmacological treatment of rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Brazil; Decision Making; Drug Substitution; Drug Therapy, Combination; Glucocorticoids; Humans; Hydroxychloroquine; Leflunomide; Methotrexate; Piperidines; Pyrimidines; Pyrroles; Rheumatology; Societies, Medical; Sulfasalazine | 2018 |
A JAK1 Selective Kinase Inhibitor and Tofacitinib Affect Macrophage Activation and Function.
Topics: Animals; Cells, Cultured; Colitis; Dextran Sulfate; Female; Humans; Janus Kinase 1; Macrophages; Mice; Mice, Inbred C57BL; Phosphorylation; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Signal Transduction | 2019 |
Clinical experiences on alopecia areata treatment with tofacitinib: A study of 63 patients.
Topics: Adolescent; Adult; Alopecia Areata; Female; Humans; Male; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Treatment Outcome; Young Adult | 2019 |
Alopecia universalis. Partial response to tofacitinib.
Topics: Adult; Alopecia; Humans; Male; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles | 2019 |
Tofacitinib enhances delivery of antibody-based therapeutics to tumor cells through modulation of inflammatory cells.
Topics: Animals; Antibodies; Arginase; Breast Neoplasms; Cell Line, Tumor; Cytokines; Disease Models, Animal; Female; Immunoconjugates; Immunotherapy; Immunotoxins; Macrophages; Mice; Mice, Nude; Monocytes; Neoplasms; Neutrophils; Piperidines; Pyrimidines; Pyrroles; RNA, Messenger; Tumor Microenvironment; Xenograft Model Antitumor Assays | 2019 |
Real-World Experience with Tofacitinib in IBD at a Tertiary Center.
Topics: Administration, Oral; Adult; Colitis; Colitis, Ulcerative; Drug Administration Schedule; Female; Humans; Janus Kinase Inhibitors; Male; Middle Aged; Piperidines; Pouchitis; Pyrimidines; Pyrroles; Remission Induction; Retrospective Studies; Tertiary Care Centers; Time Factors; Treatment Outcome | 2019 |
Successful Treatment of Pyoderma Gangrenosum with Concomitant Tofacitinib and Infliximab.
Topics: Adolescent; Drug Therapy, Combination; Female; Gastrointestinal Agents; Humans; Infliximab; Piperidines; Protein Kinase Inhibitors; Pyoderma Gangrenosum; Pyrimidines; Pyrroles; Treatment Outcome | 2019 |
Reversible eruption of neurofibromatosis associated with tofacitinib therapy for rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Fibroma; Humans; Middle Aged; Neurofibromatosis 1; Piperidines; Pyrimidines; Pyrroles; Skin Neoplasms | 2019 |
Comment on: Tofacitinib for familial Mediterranean fever: a new alternative therapy?: reply.
Topics: Familial Mediterranean Fever; Humans; Piperidines; Pyrimidines; Pyrroles | 2019 |
Comment on: Tofacitinib for familial Mediterranean fever: a new alternative therapy?
Topics: Familial Mediterranean Fever; Humans; Piperidines; Pyrimidines; Pyrroles | 2019 |
The CDK7 inhibitor THZ1 alters RNA polymerase dynamics at the 5' and 3' ends of genes.
Topics: 3' Flanking Region; 5' Flanking Region; Antineoplastic Agents; Apoptosis; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Tumor; Cell Proliferation; Cyclic N-Oxides; Cyclin-Dependent Kinase 9; Cyclin-Dependent Kinase-Activating Kinase; Cyclin-Dependent Kinases; Flavonoids; Gene Expression Regulation, Leukemic; Humans; Indolizines; Myeloid Cells; Phenylenediamines; Piperazines; Piperidines; Piperidones; Protein Kinase Inhibitors; Pyridines; Pyridinium Compounds; Pyrimidines; Pyrroles; RNA Polymerase II; Translocation, Genetic | 2019 |
A Macromolecular Janus Kinase (JAK) Inhibitor Prodrug Effectively Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice.
Topics: Animals; Colitis, Ulcerative; Colon; Dextran Sulfate; Disease Models, Animal; Inflammation; Janus Kinases; Male; Methacrylates; Mice; Piperidines; Polymers; Prodrugs; Pyrimidines; Pyrroles | 2019 |
Successful treatment of extensive calcifications and acute pulmonary involvement in dermatomyositis with the Janus-Kinase inhibitor tofacitinib - A report of two cases.
Topics: Calcinosis; Dermatomyositis; Female; Humans; Lung Diseases, Interstitial; MAP Kinase Kinase 4; Middle Aged; Piperidines; Pyrimidines; Pyrroles | 2019 |
Occurrence of Extensive Cutaneous Human Papillomavirus Infection After Initiation of Tofacitinib Therapy.
Topics: Female; Humans; Middle Aged; Papillomavirus Infections; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Skin Diseases, Viral | 2019 |
Renal expression of JAK2 is high in polycystic kidney disease and its inhibition reduces cystogenesis.
Topics: Animals; Cell Line; Cell Proliferation; Curcumin; Disease Models, Animal; Epithelial Cells; Humans; Janus Kinase 2; Kidney; Mice; Phosphorylation; Piperidines; Polycystic Kidney, Autosomal Dominant; Pyrimidines; Pyrroles; TRPP Cation Channels; Up-Regulation | 2019 |
Efficacy and safety of tofacitinib for the treatment of rheumatoid arthritis in patients from the Asia-Pacific region: Post-hoc analyses of pooled clinical study data.
Topics: Adult; Arthritis, Rheumatoid; Asia; Clinical Trials as Topic; Evidence-Based Medicine; Female; Humans; Janus Kinase Inhibitors; Male; Middle Aged; Neoplasms; Opportunistic Infections; Piperidines; Pyrimidines; Pyrroles; Recovery of Function; Remission Induction; Risk Factors; Time Factors; Treatment Outcome | 2019 |
Disorders of Hypopigmentation
Topics: Administration, Cutaneous; Administration, Oral; Autoimmune Diseases; CD8-Positive T-Lymphocytes; Counseling; Dermatologic Agents; Diagnosis, Differential; Epidermis; Humans; Janus Kinases; Melanocytes; Mycosis Fungoides; Nitriles; Phototherapy; Piperidines; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; Pyrroles; Quality of Life; Skin Pigmentation; Tinea Versicolor; Vitiligo | 2019 |
Market Access Analysis of Biologics and Small-Molecule Inhibitors for Inflammatory Bowel Disease Among US Health Insurance Policies.
Topics: Adalimumab; Antibodies, Monoclonal, Humanized; Biological Products; Colitis, Ulcerative; Crohn Disease; Databases, Factual; Gastrointestinal Agents; Health Services Accessibility; Humans; Infliximab; Insurance Coverage; Insurance, Health; Piperidines; Pyrimidines; Pyrroles; United States; Ustekinumab | 2019 |
Tofacitinib Treatment of Refractory Systemic Juvenile Idiopathic Arthritis.
Topics: Adolescent; Arthritis, Juvenile; Female; Humans; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Treatment Outcome | 2019 |
Oral Tofacitinib Treatment of Erosive Pustular Dermatosis of the Scalp.
Topics: Administration, Oral; Aged; Female; Humans; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Scalp Dermatoses; Skin Diseases, Vesiculobullous; Treatment Outcome | 2019 |
Janus kinase inhibitor tofacitinib does not facilitate the repigmentation in mouse model of rhododendrol-induced vitiligo.
Topics: Administration, Oral; Animals; Butanols; Disease Models, Animal; Humans; Janus Kinase Inhibitors; Mice; Mice, Hairless; Mice, Transgenic; Piperidines; Pyrimidines; Pyrroles; Skin Lightening Preparations; Skin Pigmentation; Treatment Failure; Vitiligo | 2019 |
An urticarial drug eruption caused by tofacitinib for alopecia universalis.
Topics: Alopecia; Drug Eruptions; Humans; Male; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Urticaria; Young Adult | 2019 |
Targeting Activated Synovial Fibroblasts in Rheumatoid Arthritis by Peficitinib.
Topics: Adamantane; Arthritis, Rheumatoid; Azetidines; Cell Proliferation; Chemokine CCL2; Fibroblasts; Humans; Interleukin-6; Janus Kinase Inhibitors; Niacinamide; Piperidines; Purines; Pyrazoles; Pyrimidines; Pyrroles; Sulfonamides; Synovial Membrane | 2019 |
Preformulation and Evaluation of Tofacitinib as a Therapeutic Treatment for Asthma.
Topics: Administration, Inhalation; Allergens; Animals; Anti-Asthmatic Agents; Asthma; Drug Compounding; Drug Stability; Female; Mice; Mice, Inbred BALB C; Piperidines; Pyrimidines; Pyroglyphidae; Pyrroles | 2019 |
Combined use of tofacitinib (pan-JAK inhibitor) and ruxolitinib (a JAK1/2 inhibitor) for refractory T-cell prolymphocytic leukemia (T-PLL) with a JAK3 mutation.
Topics: Drug Resistance, Neoplasm; Drug Therapy, Combination; Humans; Janus Kinase 1; Janus Kinase 2; Janus Kinase 3; Leukemia, Prolymphocytic, T-Cell; Male; Middle Aged; Mutation; Nitriles; Piperidines; Prognosis; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; Pyrroles | 2019 |
JAK3/STAT3 oncogenic pathway and PRDM1 expression stratify clinicopathologic features of extranodal NK/T‑cell lymphoma, nasal type.
Topics: Apoptosis; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Female; Gene Expression Regulation, Neoplastic; Humans; Janus Kinase 3; Lymphoma, T-Cell; Male; Middle Aged; Mutation; Phosphorylation; Piperidines; Positive Regulatory Domain I-Binding Factor 1; Pyrimidines; Pyrroles; STAT3 Transcription Factor | 2019 |
Rapid Onset of Tofacitinib Induction Therapy for the Treatment of Ulcerative Colitis.
Topics: Colitis, Ulcerative; Humans; Piperidines; Pyrimidines; Pyrroles | 2019 |
Economic Evaluation of Sarilumab in the Treatment of Adult Patients with Moderately-to-Severely Active Rheumatoid Arthritis Who Have an Inadequate Response to Conventional Synthetic Disease-Modifying Antirheumatic Drugs.
Topics: Adalimumab; Adolescent; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Certolizumab Pegol; Cost-Benefit Analysis; Etanercept; Female; Humans; Male; Methotrexate; Middle Aged; Piperidines; Pyrimidines; Pyrroles; Young Adult | 2019 |
Successful treatment of arthritis and rash with tofacitinib in systemic lupus erythematosus: the experience from a single centre.
Topics: Adolescent; Adult; Arthritis; Exanthema; Female; Humans; Lupus Erythematosus, Systemic; Male; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Treatment Outcome; Young Adult | 2019 |
A pilot study of 2% tofacitinib cream with narrowband ultraviolet B for the treatment of facial vitiligo.
Topics: Administration, Cutaneous; Adult; Combined Modality Therapy; Facial Dermatoses; Female; Humans; Male; Pilot Projects; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Severity of Illness Index; Skin Cream; Ultraviolet Therapy; Vitiligo | 2019 |
Dynamics of body mass index and visceral adiposity index in patients with rheumatoid arthritis treated with tofacitinib.
Topics: Adiposity; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Body Mass Index; Female; Humans; Intra-Abdominal Fat; Male; Middle Aged; Obesity, Abdominal; Piperidines; Prospective Studies; Pyrimidines; Pyrroles; Waist Circumference | 2019 |
Tofacitinib modulates the VZV-specific CD4+ T cell immune response in vitro in lymphocytes of patients with rheumatoid arthritis.
Topics: Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Arthritis, Rheumatoid; CD4-Positive T-Lymphocytes; Cell Differentiation; Cell Proliferation; Herpesvirus 3, Human; Humans; Immunity, Cellular; Interferon-gamma; Lectins, C-Type; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Receptors, CCR5; Receptors, CXCR3; Th1 Cells | 2019 |
Chronic Inguinal Lymphadenitis in a Patient With Rheumatoid Arthritis Being Treated With Tofacitinib: Remission With Antituberculous Therapy and Discontinuation of JAK Inhibition.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Lymphadenitis; Piperidines; Pyrimidines; Pyrroles | 2020 |
Effect of platinum‑based chemotherapy on the expression of natural killer group 2 member D ligands, programmed cell death‑1 ligand 1 and HLA class I in non‑small cell lung cancer.
Topics: Aged; Antineoplastic Agents; Apoptosis; B7-H1 Antigen; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Cell Proliferation; Cisplatin; Cytotoxicity, Immunologic; Drug Resistance, Neoplasm; Drug Therapy, Combination; Female; Follow-Up Studies; Gene Expression Regulation, Neoplastic; GPI-Linked Proteins; Histocompatibility Antigens Class I; Humans; Intercellular Signaling Peptides and Proteins; Janus Kinases; Killer Cells, Natural; Ligands; Lung Neoplasms; Male; Middle Aged; NK Cell Lectin-Like Receptor Subfamily K; Piperidines; Prognosis; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; STAT Transcription Factors; Tumor Cells, Cultured | 2019 |
A multi-item Physician Global Assessment scale to assess psoriasis disease severity: validation based on four phase III tofacitinib studies.
Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Clinical Trials, Phase III as Topic; Female; Humans; Janus Kinase Inhibitors; Male; Middle Aged; Piperidines; Psoriasis; Pyrimidines; Pyrroles; Quality of Life; Reproducibility of Results; Severity of Illness Index; Skin; Treatment Outcome; Young Adult | 2019 |
Budget impact of introducing tofacitinib to the public hospital formulary in Hong Kong, 2017-2021.
Topics: Arthritis, Rheumatoid; Biological Products; Health Care Costs; Hong Kong; Hospitals, Public; Humans; Linear Models; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles | 2019 |
Azomethine ylide cycloaddition: a versatile tool for preparing novel pyrrolizidino-spiro-oxindolo hybrids of the doubly conjugated alkamide piperine.
Topics: Alkaloids; Azo Compounds; Benzodioxoles; Cycloaddition Reaction; Models, Molecular; Molecular Conformation; Oxindoles; Piperidines; Polyunsaturated Alkamides; Pyrroles; Spiro Compounds; Stereoisomerism; Thiosemicarbazones | 2020 |
Janus kinase inhibition induces disease remission in cutaneous sarcoidosis and granuloma annulare.
Topics: Adult; Aged; Biopsy; Female; Granuloma Annulare; Humans; Janus Kinase Inhibitors; Male; Middle Aged; Piperidines; Prospective Studies; Pyrimidines; Pyrroles; Remission Induction; Sarcoidosis; Severity of Illness Index; Skin; Treatment Outcome | 2020 |
Tofacitinib: raising awareness of mycoses.
Topics: Aged; Arthritis, Rheumatoid; Fingers; Humans; Male; Mycoses; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles | 2019 |
Inhibitors of AKT kinase increase LDL receptor mRNA expression by two different mechanisms.
Topics: Aminopyridines; Animals; Benzimidazoles; CHO Cells; Cricetinae; Cricetulus; Hep G2 Cells; Heterocyclic Compounds, 3-Ring; Humans; Imidazoles; Phosphorylcholine; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrazoles; Pyrimidines; Pyrroles; Quinoxalines; Receptors, LDL; Ribonucleosides; RNA Stability; RNA, Messenger; Transcriptional Activation | 2019 |
Apremilast and tofacitinib exert differential effects in the humanized mouse model of alopecia areata.
Topics: Alopecia Areata; Animals; Mice; Piperidines; Pyrimidines; Pyrroles; Thalidomide | 2020 |
Effect of Janus Kinase Inhibitor Treatment on Anterior Uveitis and Associated Macular Edema in an Adult Patient with Juvenile Idiopathic Arthritis.
Topics: Administration, Oral; Arthritis, Juvenile; Female; Humans; Janus Kinase Inhibitors; Macula Lutea; Macular Edema; Piperidines; Pyrimidines; Pyrroles; Tomography, Optical Coherence; Uveitis, Anterior; Visual Acuity; Young Adult | 2019 |
Tofacitinib inhibits ox-LDL-induced adhesion of THP-1 monocytes to endothelial cells.
Topics: Cell Adhesion; Cell Line; Cytoprotection; Endothelial Cells; Humans; L-Lactate Dehydrogenase; Lipoproteins, LDL; Monocytes; NF-kappa B; Piperidines; Pyrimidines; Pyrroles; Reactive Oxygen Species | 2019 |
IRF1 is critical for the TNF-driven interferon response in rheumatoid fibroblast-like synoviocytes : JAKinibs suppress the interferon response in RA-FLSs.
Topics: Animals; Arthritis, Rheumatoid; Azetidines; Biomarkers; Female; Gene Expression; Humans; Inflammation; Interferon Regulatory Factor-1; Interferons; Janus Kinase Inhibitors; Mice; Mice, Inbred C57BL; Mice, Transgenic; Piperidines; Purines; Pyrazoles; Pyrimidines; Pyrroles; Signal Transduction; Sulfonamides; Synovial Membrane; Synoviocytes; Tumor Necrosis Factor-alpha | 2019 |
Tofacitinib as a treatment of alopecia areata in adolescents.
Topics: Administration, Oral; Adolescent; Alopecia Areata; Female; Humans; Male; Mexico; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Retrospective Studies; Severity of Illness Index; Treatment Outcome; Young Adult | 2019 |
Comparison of effects of midostaurin, crenolanib, quizartinib, gilteritinib, sorafenib and BLU-285 on oncogenic mutants of KIT, CBL and FLT3 in haematological malignancies.
Topics: Aniline Compounds; Antineoplastic Agents; Benzimidazoles; Benzothiazoles; Cell Line, Tumor; Drug Screening Assays, Antitumor; fms-Like Tyrosine Kinase 3; Hematologic Neoplasms; Humans; Mutant Proteins; Phenylurea Compounds; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-cbl; Proto-Oncogene Proteins c-kit; Pyrazines; Pyrazoles; Pyrroles; Sorafenib; Staurosporine; Triazines | 2019 |
Tofacitinib for the treatment of recalcitrant palmoplantar pustulosis: A case report.
Topics: Female; Humans; Middle Aged; Piperidines; Protein Kinase Inhibitors; Psoriasis; Pyrimidines; Pyrroles | 2020 |
Modeling Combined Anti-Inflammatory Effects of Dexamethasone and Tofacitinib in Arthritic Rats.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Dexamethasone; Disease Progression; Dose-Response Relationship, Drug; Drug Therapy, Combination; Edema; Male; Pilot Projects; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Rats; Rats, Inbred Lew | 2019 |
Comparison of baricitinib, upadacitinib, and tofacitinib mediated regulation of cytokine signaling in human leukocyte subpopulations.
Topics: Arthritis, Rheumatoid; Azetidines; Biomarkers; Cytokines; Flow Cytometry; Heterocyclic Compounds, 3-Ring; Humans; Janus Kinase Inhibitors; Leukocytes, Mononuclear; Piperidines; Protein Kinase Inhibitors; Purines; Pyrazoles; Pyrimidines; Pyrroles; Signal Transduction; Sulfonamides | 2019 |
Retrospective Claims Analysis Indirectly Comparing Medication Adherence and Persistence Between Intravenous Biologics and Oral Small-Molecule Therapies in Inflammatory Bowel Diseases.
Topics: Administration, Intravenous; Administration, Oral; Adult; Aged; Antibodies, Monoclonal, Humanized; Arthritis, Rheumatoid; Biological Products; Female; Humans; Inflammatory Bowel Diseases; Infliximab; Insurance Claim Review; Male; Medication Adherence; Medication Therapy Management; Middle Aged; Piperidines; Proportional Hazards Models; Pyrimidines; Pyrroles; Retrospective Studies; United States | 2019 |
Risk Factors for Major Adverse Cardiovascular Events in Phase III and Long-Term Extension Studies of Tofacitinib in Patients With Rheumatoid Arthritis.
Topics: Aged; Arthritis, Rheumatoid; Blood Sedimentation; Cardiovascular Diseases; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Clinical Trials, Phase III as Topic; Female; Humans; Incidence; Male; Middle Aged; Myocardial Infarction; Piperidines; Proportional Hazards Models; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Risk Factors; Stroke; Treatment Outcome | 2019 |
Tofacitinib facilitates the expansion of myeloid-derived suppressor cells and ameliorates interstitial lung disease in SKG mice.
Topics: Animals; Cell Differentiation; Cell Proliferation; Dendritic Cells; Disease Models, Animal; Immunity, Innate; Lung Diseases, Interstitial; Male; Mice; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Th17 Cells | 2019 |
Outcomes of dose reduction, withdrawal, and restart of tofacitinib in patients with rheumatoid arthritis: a prospective observational study.
Topics: Aged; Arthritis, Rheumatoid; Female; Humans; Male; Middle Aged; Piperidines; Prospective Studies; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Symptom Flare Up | 2019 |
Experience with tofacitinib in Canada: patient characteristics and treatment patterns in rheumatoid arthritis over 3 years.
Topics: Adult; Age Factors; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Canada; Databases, Factual; Female; Humans; Male; Middle Aged; Piperidines; Practice Patterns, Physicians'; Pyrimidines; Pyrroles; Treatment Outcome | 2020 |
Tofacitinib Is a Mechanism-Based Inactivator of Cytochrome P450 3A4.
Topics: Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Enzyme Assays; Humans; Ketoconazole; Male; Microsomes, Liver; NADP; Piperidines; Pyrimidines; Pyrroles | 2019 |
Breastfeeding with Inflammatory Bowel Disease.
Topics: Aminosalicylic Acid; Biological Products; Breast Feeding; Female; Humans; Inflammatory Bowel Diseases; Methotrexate; Piperidines; Pyrimidines; Pyrroles | 2019 |
2019 Update of the American College of Rheumatology/Spondylitis Association of America/Spondyloarthritis Research and Treatment Network Recommendations for the Treatment of Ankylosing Spondylitis and Nonradiographic Axial Spondyloarthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Biological Products; Biosimilar Pharmaceuticals; Deprescriptions; Humans; Magnetic Resonance Imaging; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Radiography; Societies, Medical; Spondylarthropathies; Spondylitis, Ankylosing; Tumor Necrosis Factor Inhibitors | 2019 |
Improvement of lymphangioleiomyomatosis following successful tofacitinib treatment for refractory synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome.
Topics: Acquired Hyperostosis Syndrome; Adult; Female; Humans; Janus Kinase 3; Lymphangioleiomyomatosis; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles | 2019 |
Docking structurally similar analogues: Dealing with the false-positive.
Topics: Algorithms; Janus Kinase 3; Molecular Dynamics Simulation; Piperidines; Protein Binding; Pyrimidines; Pyrroles; Quantitative Structure-Activity Relationship | 2019 |
Letter: tofacitinib use for biologic-refractory paediatric inflammatory bowel disease.
Topics: Biological Products; Child; Humans; Inflammatory Bowel Diseases; Janus Kinase Inhibitors; Piperidines; Pyrimidines; Pyrroles | 2019 |
Venous thromboembolic events in the tofacitinib ulcerative colitis clinical development programme.
Topics: Adult; Aged; Cohort Studies; Colitis, Ulcerative; Female; Humans; Incidence; Male; Middle Aged; Piperidines; Pulmonary Embolism; Pyrimidines; Pyrroles; Retrospective Studies; Risk Factors; Venous Thromboembolism; Venous Thrombosis; Young Adult | 2019 |
Reply: Treatment of anti-MDA5 autoantibody-positive juvenile dermatomyositis using tofacitinib.
Topics: Autoantibodies; Dermatomyositis; Humans; Piperidines; Pyrimidines; Pyrroles | 2019 |
Treatment of anti-MDA5 autoantibody-positive juvenile dermatomyositis using tofacitinib.
Topics: Autoantibodies; Dermatomyositis; Humans; Interferon Type I; Piperidines; Pyrimidines; Pyrroles | 2019 |
Open-label pilot study of tofacitinib 2% for the treatment of refractory vitiligo.
Topics: Humans; Pilot Projects; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Treatment Outcome; Vitiligo | 2020 |
Experience with oral tofacitinib in two adolescents and seven adults with alopecia areata.
Topics: Administration, Oral; Adolescent; Adult; Alopecia; Alopecia Areata; Female; Humans; Male; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Retrospective Studies; Treatment Outcome; Young Adult | 2019 |
The JAK inhibitor tofacitinib ameliorates immune‑mediated liver injury in mice.
Topics: Animals; Hepatitis, Autoimmune; Interferon-gamma; Interleukin-10; Janus Kinase Inhibitors; Liver; Male; Mice; Mice, Inbred C57BL; Piperidines; Pyrimidines; Pyrroles; T-Lymphocytes, Regulatory; Th17 Cells | 2019 |
Tofacitinib Receives New Boxed Safety Warning.
Topics: Drug Dosage Calculations; Drug Labeling; Humans; Patient Safety; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Thrombosis | 2019 |
Intestinal breast cancer resistance protein (BCRP) requires Janus kinase 3 activity for drug efflux and barrier functions in obesity.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; beta Catenin; Biological Transport; Colon; Epithelial Cells; HT29 Cells; Humans; Insulin; Intestinal Mucosa; Janus Kinase 3; Mice; Mice, Knockout; Neoplasm Proteins; Obesity; Phosphorylation; Piperidines; Pyrimidines; Pyrroles; Tissue Inhibitor of Metalloproteinase-1 | 2019 |
Quantitative tracking of inflammatory activity at the peak and trough plasma levels of tofacitinib, a Janus kinase inhibitor, via in vivo
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Drug Administration Schedule; Fluorodeoxyglucose F18; Janus Kinase Inhibitors; Joints; Male; Mice, Inbred DBA; Piperidines; Positron-Emission Tomography; Predictive Value of Tests; Pyrimidines; Pyrroles; Radiopharmaceuticals; Whole Body Imaging | 2019 |
Tofacitinib in Pediatric Psoriasis: An Open-Label Trial to Study Its Safety and Efficacy in Children.
Topics: Adolescent; Child; Female; Humans; Male; Piperidines; Protein Kinase Inhibitors; Psoriasis; Pyrimidines; Pyrroles; Treatment Outcome | 2020 |
Response of alopecia areata of the beard to oral tofacitinib.
Topics: Administration, Oral; Adult; Aged; Alopecia Areata; Cheek; Chin; Humans; Janus Kinases; Male; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Retrospective Studies; Scalp; Treatment Outcome; Young Adult | 2020 |
Dexamethasone and Tofacitinib suppress NADPH oxidase expression and alleviate very-early-onset ileocolitis in mice deficient in GSH peroxidase 1 and 2.
Topics: Animals; Apoptosis; Crohn Disease; Dexamethasone; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Ileum; Inflammation; Inflammatory Bowel Diseases; Mice; Mice, Inbred C57BL; NADPH Oxidase 1; NADPH Oxidases; Oxidation-Reduction; Peroxidases; Piperidines; Pyrimidines; Pyrroles | 2019 |
Metabolic Activation of Tofacitinib Mediated by Myeloperoxidase
Topics: Acetylcysteine; Activation, Metabolic; Animals; Antirheumatic Agents; Hypochlorous Acid; Leukocytes; Leukopenia; Peroxidase; Piperidines; Pyrimidines; Pyrroles; Rats, Sprague-Dawley | 2019 |
Inhibition of JAK-STAT and NF-κB signalling systems could be a novel therapeutic target against insulin resistance and type 2 diabetes.
Topics: Animals; Aspirin; Blood Glucose; Cytokines; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Female; Hyperglycemia; Hypoglycemic Agents; Insulin; Insulin Resistance; Interleukin-6; Janus Kinases; Male; NF-kappa B; Piperidines; Pyrimidines; Pyrroles; Rats; Rats, Wistar; Serum Amyloid A Protein; Signal Transduction; STAT Transcription Factors; Tumor Necrosis Factor-alpha | 2019 |
Prevalence of endoscopic improvement and remission according to patient-reported outcomes in ulcerative colitis.
Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Clinical Trials as Topic; Cohort Studies; Colitis, Ulcerative; Endoscopy, Gastrointestinal; Female; Gastrointestinal Agents; Gastrointestinal Hemorrhage; Humans; Induction Chemotherapy; Infliximab; Maintenance Chemotherapy; Male; Middle Aged; Patient Reported Outcome Measures; Piperidines; Prevalence; Pyrimidines; Pyrroles; Remission Induction; Young Adult | 2020 |
Tofacitinib for the Treatment of Refractory Polymyositis.
Topics: Antirheumatic Agents; Biopsy; Disease Progression; Drug Resistance, Multiple; Electromyography; Female; Humans; Janus Kinase Inhibitors; Medication Therapy Management; Middle Aged; Monitoring, Immunologic; Muscle Strength; Muscle Weakness; Piperidines; Polymyositis; Pyrimidines; Pyrroles; Treatment Outcome | 2019 |
A case of Takayasu arteritis complicated by refractory ulcerative colitis successfully treated with tofacitinib.
Topics: Adolescent; Colitis, Ulcerative; Female; Humans; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Takayasu Arteritis; Treatment Outcome | 2020 |
Changes in Serum Cytokines May Predict Therapeutic Efficacy of Tofacitinib in Rheumatoid Arthritis.
Topics: Adult; Arthritis, Rheumatoid; Cytokines; Female; Humans; Interleukin-17; Interleukin-6; Interleukins; Male; Middle Aged; Piperidines; Pyrimidines; Pyrroles; Tumor Necrosis Factor-alpha | 2019 |
IgA Vasculitis Developed as an Adverse Effect of Tofacitinib Taken for Rheumatoid Arthritis.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Immunoglobulin A; Piperidines; Pyrimidines; Pyrroles; Tumor Necrosis Factor-alpha; Vasculitis | 2020 |
Alterations of voluntary behavior in the course of disease progress and pharmacotherapy in mice with collagen-induced arthritis.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Disease Models, Animal; Disease Progression; Humans; Joints; Male; Mice, Inbred DBA; Motor Activity; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Synovitis; Temperature | 2019 |
Treatment-resistant eosinophilic oesophagitis successfully managed with tofacitinib.
Topics: Adult; Arthralgia; Diagnosis, Differential; Eosinophilic Esophagitis; Humans; Male; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Treatment Outcome | 2019 |
Janus kinase inhibitors for the treatment of rheumatoid arthritis demonstrate similar profiles of in vitro cytokine receptor inhibition.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Azetidines; Cell Line; Cytokines; Enzyme Assays; Female; Healthy Volunteers; Heterocyclic Compounds, 3-Ring; Humans; Inhibitory Concentration 50; Janus Kinase 1; Janus Kinase Inhibitors; Male; Piperidines; Purines; Pyrazoles; Pyridines; Pyrimidines; Pyrroles; Receptors, Cytokine; Sulfonamides; Triazoles | 2019 |
"Tofacitinib Is a Mechanism-Based Inactivator of Cytochrome P450 3A4": Revisiting the Significance of the Epoxide Intermediate and Glutathione Trapping.
Topics: Cytochrome P-450 CYP3A; Epoxy Compounds; Glutathione; Piperidines; Pyrimidines; Pyrroles | 2020 |
Inferring disease severity in rheumatoid arthritis using predictive modeling in administrative claims databases.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Databases, Factual; Female; Humans; Insurance Claim Review; Male; Middle Aged; Models, Biological; Piperidines; Pyrimidines; Pyrroles; Severity of Illness Index | 2019 |
Low-dose tofacitinib for treating patients with severe alopecia areata: an efficient and cost-saving regimen.
Topics: Adult; Alopecia Areata; Cost Savings; Female; Humans; Male; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Severity of Illness Index; Treatment Outcome; Young Adult | 2019 |
Impact of Janus Kinase Inhibition with Tofacitinib on Fundamental Processes of Bone Healing.
Topics: Cell Differentiation; Cell Hypoxia; Cell Movement; Cell Survival; Cells, Cultured; Chondrogenesis; Collagen Type I; Collagen Type I, alpha 1 Chain; Core Binding Factor Alpha 1 Subunit; Humans; Janus Kinase Inhibitors; Janus Kinases; Mesenchymal Stem Cells; Osteogenesis; Piperidines; Pyrimidines; Pyrroles | 2020 |
Letter: new insights on tofacitinib dose de-escalation.
Topics: Colitis, Ulcerative; Humans; Piperidines; Pyrimidines; Pyrroles | 2020 |
Methotrexate-Induced Pneumonitis in Rheumatoid Arthritis: Long-term Treatment With Tofacitinib Therapy.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Piperidines; Pneumonia; Pyrimidines; Pyrroles; Treatment Outcome | 2021 |
Relative efficacy and safety of tofacitinib, baricitinib, upadacitinib, and filgotinib in comparison to adalimumab in patients with active rheumatoid arthritis.
Topics: Adalimumab; Antirheumatic Agents; Arthritis, Rheumatoid; Azetidines; Bayes Theorem; Drug Therapy, Combination; Heterocyclic Compounds, 3-Ring; Humans; Methotrexate; Piperidines; Purines; Pyrazoles; Pyridines; Pyrimidines; Pyrroles; Sulfonamides; Treatment Outcome; Triazoles | 2020 |
Tofacitinib in refractory adult-onset Still's disease: 14 cases from a single centre in China.
Topics: Adolescent; Adult; Aged; Female; Humans; Janus Kinase Inhibitors; Male; Middle Aged; Piperidines; Pyrimidines; Pyrroles; Retreatment; Still's Disease, Adult-Onset | 2020 |
Potential synergistic effects of novel hematopoietic prostaglandin D synthase inhibitor TAS-205 and different types of anti-allergic medicine on nasal obstruction in a Guinea pig model of experimental allergic rhinitis.
Topics: Acetates; Animals; Anti-Allergic Agents; Cell Line; Cyclopropanes; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Enzyme Inhibitors; Guinea Pigs; Humans; Intramolecular Oxidoreductases; Lipocalins; Male; Morpholines; Nasal Mucosa; Nasal Obstruction; Ovalbumin; Piperidines; Prostaglandin D2; Pyrroles; Quality of Life; Quinolines; Rats; Rhinitis, Allergic; Sulfides; Terfenadine | 2020 |
A case of refractory chronic pouchitis successfully treated with tofacitinib.
Topics: Adolescent; Adult; Colitis, Ulcerative; Female; Humans; Piperidines; Pouchitis; Proctocolectomy, Restorative; Pyrimidines; Pyrroles; Young Adult | 2020 |
Long-term effectiveness of live herpes zoster vaccine in patients with rheumatoid arthritis subsequently treated with tofacitinib.
Topics: Aged; Arthritis, Rheumatoid; Combined Modality Therapy; Female; Follow-Up Studies; Herpes Zoster Vaccine; Humans; Male; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Severity of Illness Index; Time Factors; Treatment Outcome; Vaccines, Live, Unattenuated | 2020 |
Multicentric reticulohistiocytosis: A case report treated with tofacitinib.
Topics: Histiocytosis, Non-Langerhans-Cell; Humans; Piperidines; Pyrimidines; Pyrroles | 2021 |
Successful remission with tofacitinib in a patient with refractory Takayasu arteritis complicated by ulcerative colitis.
Topics: Adult; Colitis, Ulcerative; Female; Humans; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Remission Induction; Takayasu Arteritis | 2020 |
Pharmacological Management of Adult Outpatients With Moderate to Severely Active Ulcerative Colitis: Clinical Decision Support Tool.
Topics: Adult; Ambulatory Care; Biological Products; Clinical Decision-Making; Colitis, Ulcerative; Decision Support Techniques; Drug Therapy, Combination; Humans; Immunologic Factors; Methotrexate; Piperidines; Practice Guidelines as Topic; Pyrimidines; Pyrroles; Severity of Illness Index | 2020 |
Tofacitinib for ulcerative colitis: results of the prospective Dutch Initiative on Crohn and Colitis (ICC) registry.
Topics: Adult; Antibodies, Monoclonal, Humanized; Colitis, Ulcerative; Crohn Disease; Female; Humans; Male; Middle Aged; Netherlands; Piperidines; Prospective Studies; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Registries; Treatment Outcome; Tumor Necrosis Factor-alpha; Ustekinumab | 2020 |
Tofacitinib cream plus narrowband ultraviolet B phototherapy for segmental vitiligo in a child.
Topics: Child; Humans; Phototherapy; Piperidines; Pyrimidines; Pyrroles; Treatment Outcome; Ultraviolet Therapy; Vitiligo | 2020 |
Tofacitinib in psoriatic arthritis patients: skin signs and symptoms and health-related quality of life from two randomized phase 3 studies.
Topics: Adult; Arthritis, Psoriatic; Double-Blind Method; Humans; Piperidines; Psoriasis; Pyrimidines; Pyrroles; Quality of Life; Treatment Outcome | 2020 |
The use of Janus kinase inhibitors in the time of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Topics: Arthritis, Rheumatoid; Azetidines; Betacoronavirus; Colitis, Ulcerative; Coronavirus Infections; COVID-19; Cytokines; Dermatitis, Atopic; Heterocyclic Compounds, 3-Ring; Humans; Immunomodulation; Janus Kinases; Nitriles; Pandemics; Piperidines; Pneumonia, Viral; Primary Myelofibrosis; Purines; Pyrazoles; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; SARS-CoV-2; STAT Transcription Factors; Sulfonamides | 2020 |
Comparison of the effects of tofacitinib and adalimumab on transcolonoscopic ph and calprotectin levels in patients with ulcerative colitis.
Topics: Adalimumab; Adolescent; Adult; Aged; Colitis, Ulcerative; Female; Humans; Hydrogen-Ion Concentration; Leukocyte L1 Antigen Complex; Male; Middle Aged; Piperidines; Pyrimidines; Pyrroles; Young Adult | 2020 |
Cost-effectiveness analysis of treatment sequences containing tofacitinib for the treatment of rheumatoid arthritis in Spain.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cost-Benefit Analysis; Drug Therapy, Combination; Humans; Methotrexate; Piperidines; Pyrimidines; Pyrroles; Spain; Treatment Outcome | 2020 |
Tofacitinib-induced remission in refractory adult-onset Still's disease complicated by macrophage activation syndrome.
Topics: Aged; Fatal Outcome; Female; Humans; Janus Kinases; Lymphohistiocytosis, Hemophagocytic; Macrophage Activation; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Remission Induction; Still's Disease, Adult-Onset | 2020 |
Efficacy of tofacitinib in synovitis, acne, pustulosis, hyperostosis and osteitis syndrome: a pilot study with clinical and MRI evaluation.
Topics: Acquired Hyperostosis Syndrome; Adult; Female; Humans; Pilot Projects; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Treatment Outcome | 2020 |
Gepants.
Topics: Calcitonin Gene-Related Peptide Receptor Antagonists; Humans; Migraine Disorders; Piperidines; Pyridines; Pyrroles; Spiro Compounds | 2020 |
Letter: corticosteroid use alongside tofacitinib in OCTAVE Open.
Topics: Adrenal Cortex Hormones; Colitis, Ulcerative; Humans; Piperidines; Pyrimidines; Pyrroles | 2020 |
Letter: corticosteroid use alongside tofacitinib in OCTAVE Open. Authors' reply.
Topics: Adrenal Cortex Hormones; Colitis, Ulcerative; Humans; Piperidines; Pyrimidines; Pyrroles | 2020 |
Case Report of a SARS-CoV-2 Infection in a Patient With Ulcerative Colitis on Tofacitinib.
Topics: Adult; Betacoronavirus; Colitis, Ulcerative; Colonoscopy; Comorbidity; Coronavirus Infections; COVID-19; Female; Humans; Medication Therapy Management; Pandemics; Patient Acuity; Piperidines; Pneumonia, Viral; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; SARS-CoV-2; Symptom Assessment; Treatment Outcome | 2020 |
Novel pyrrolobenzodiazepine benzofused hybrid molecules inhibit NF-κB activity and synergise with bortezomib and ibrutinib in hematological cancers.
Topics: Adenine; Animals; Apoptosis; Benzodiazepines; Bortezomib; Hematologic Neoplasms; Leukemia, Lymphocytic, Chronic, B-Cell; Mice; Mice, Inbred NOD; Mice, SCID; NF-kappa B; Piperidines; Pyrroles; Tumor Microenvironment | 2021 |
Incorporating Fecal Calprotectin Into Clinical Practice for Patients With Moderate-to-Severely Active Ulcerative Colitis Treated With Biologics or Small-Molecule Inhibitors.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Biological Products; Colitis, Ulcerative; Colonoscopy; Feces; Gastrointestinal Agents; Humans; Infliximab; Leukocyte L1 Antigen Complex; Outcome Assessment, Health Care; Patient Reported Outcome Measures; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Severity of Illness Index; Treatment Outcome | 2020 |
Full histological and clinical regression of morphea with tofacitinib.
Topics: Humans; Piperidines; Pyrimidines; Pyrroles; Scleroderma, Localized | 2020 |
Letter: thromboembolic and cardiovascular events with tofacitinib in ulcerative colitis-two cases in real world clinical practice.
Topics: Colitis, Ulcerative; Humans; Piperidines; Pyrimidines; Pyrroles | 2020 |
Letter: thromboembolic and cardiovascular events with tofacitinib in ulcerative colitis-two cases in real world clinical practice. Authors' reply.
Topics: Colitis, Ulcerative; Humans; Piperidines; Pyrimidines; Pyrroles | 2020 |
Tailoring Tofacitinib Oral Therapy in Rheumatoid Arthritis: The TuTORApp-A Usability Study.
Topics: Adolescent; Adult; Arthritis, Rheumatoid; Computer Security; Female; Humans; Medication Adherence; Mobile Applications; Piperidines; Pregnancy; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Young Adult | 2020 |
Syntheses and Reactions of Pyrroline, Piperidine Nitroxide Phosphonates.
Topics: Alkenes; Carbon; Molecular Structure; Nitrogen Oxides; Organophosphonates; Piperidines; Pyrroles; Stereoisomerism | 2020 |
Susceptibility and severity of COVID-19 in patients treated with bDMARDS and tsDMARDs: a population-based study.
Topics: Abatacept; Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Azetidines; Betacoronavirus; Coronavirus Infections; COVID-19; Disease Susceptibility; Female; Hospitalization; Humans; Interleukin 1 Receptor Antagonist Protein; Italy; Janus Kinase Inhibitors; Logistic Models; Male; Middle Aged; Pandemics; Piperidines; Pneumonia, Viral; Proportional Hazards Models; Purines; Pyrazoles; Pyrimidines; Pyrroles; Rheumatic Diseases; Risk Factors; SARS-CoV-2; Severity of Illness Index; Sulfonamides; Tumor Necrosis Factor Inhibitors; Ustekinumab | 2020 |
Reply to Letter to Editor from Veeravalli and Dash on "Tofacitinib Is a Mechanism-Based Inactivator of Cytochrome P450 3A4: Revisiting the Significance of the Epoxide Intermediate and Glutathione Trapping".
Topics: Cytochrome P-450 CYP3A; Epoxy Compounds; Glutathione; Piperidines; Pyrimidines; Pyrroles | 2020 |
Successful therapy of palmoplantar pustulosis with tofacitinib-Report on three cases.
Topics: Humans; Piperidines; Psoriasis; Pyrimidines; Pyrroles | 2020 |
Tofacitinib for Refractory Immune-Related Colitis from PD-1 Therapy.
Topics: Colitis; Colitis, Ulcerative; Humans; Piperidines; Programmed Cell Death 1 Receptor; Pyrimidines; Pyrroles | 2020 |
Lasmiditan (Reyvow) and ubrogepant (Ubrelvy) for acute treatment of migraine.
Topics: Animals; Benzamides; Humans; Migraine Disorders; Piperidines; Pyridines; Pyrroles | 2020 |
Combined anti-fibrotic and anti-inflammatory properties of JAK-inhibitors on macrophages in vitro and in vivo: Perspectives for scleroderma-associated interstitial lung disease.
Topics: Animals; Anti-Inflammatory Agents; Cell Differentiation; Chemokine CXCL13; Female; Gene Expression Regulation; Hypochlorous Acid; Janus Kinase 1; Janus Kinase 2; Janus Kinase 3; Lung; Lung Diseases, Interstitial; Macrophage Activation; Macrophages; Mice; Mice, Inbred C57BL; Nitriles; Piperidines; Primary Cell Culture; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; Pyrroles; Receptors, Immunologic; Scleroderma, Systemic; Suppressor of Cytokine Signaling 3 Protein | 2020 |
Topics: Aminopyridines; Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Synergism; Genes, ras; Heterografts; Humans; Indoles; Male; MAP Kinase Signaling System; Mice, Inbred NOD; Mice, SCID; Mitogen-Activated Protein Kinase Kinases; Mutation; Neoplasm Recurrence, Local; Neuroblastoma; Piperidines; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Pyridones; Pyrimidines; Pyrimidinones; Pyrroles; Triazoles; Vemurafenib | 2020 |
Two cases in which tofacitinib effectively treated both ulcerative colitis and alopecia areata.
Topics: Adult; Alopecia Areata; Colitis, Ulcerative; Female; Humans; Infliximab; Male; Piperidines; Pyrimidines; Pyrroles; Young Adult | 2020 |
Tofacitinib in Hypertrophic Lichen Planus.
Topics: Humans; Lichen Planus; Piperidines; Pyrimidines; Pyrroles | 2020 |
Folliculitis decalvans responsive to tofacitinib: A case series.
Topics: Alopecia; Folliculitis; Humans; Piperidines; Pyrimidines; Pyrroles | 2020 |
Safety of Tofacitinib in a Real-World Cohort of Patients With Ulcerative Colitis.
Topics: Colitis, Ulcerative; Humans; Piperidines; Pyrimidines; Pyrroles | 2021 |
Comment on 'Successful treatment of recalcitrant nodular prurigo with tofacitinib'.
Topics: Humans; Piperidines; Prurigo; Pyrimidines; Pyrroles | 2020 |
Pain Freedom at 2 to 8 Hours With Lasmiditan: A Comparison With Rimegepant and Ubrogepant.
Topics: Benzamides; Freedom; Humans; Pain; Piperidines; Pyridines; Pyrroles | 2020 |
Incidence of venous and arterial thromboembolic events reported in the tofacitinib rheumatoid arthritis, psoriasis and psoriatic arthritis development programmes and from real-world data.
Topics: Adult; Aged; Antirheumatic Agents; Clinical Trials as Topic; Female; Humans; Incidence; Male; Middle Aged; Observational Studies as Topic; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Rheumatic Diseases; Thromboembolism | 2020 |
Tofacitinib, an Oral Janus Kinase Inhibitor: Analysis of Malignancy (Excluding Nonmelanoma Skin Cancer) Events Across the Ulcerative Colitis Clinical Program.
Topics: Clinical Trials, Phase III as Topic; Colitis, Ulcerative; Humans; Janus Kinase Inhibitors; Neoplasms; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Skin Neoplasms; Treatment Outcome | 2021 |
Sitagliptin and tofacitinib ameliorate adjuvant induced arthritis via modulating the cross talk between JAK/STAT and TLR-4/NF-κB signaling pathways.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Blood Glucose; Drug Synergism; Drug Therapy, Combination; Hypoglycemic Agents; Interleukin-6; Janus Kinases; Lipids; Male; NF-kappa B; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptor Cross-Talk; Signal Transduction; Sitagliptin Phosphate; STAT Transcription Factors; STAT3 Transcription Factor; Toll-Like Receptor 4 | 2020 |
Correlation between serum granulysin level and clinical activity in patients with alopecia areata before and after tofacitinib therapy.
Topics: Alopecia Areata; Humans; Piperidines; Pyrimidines; Pyrroles | 2021 |
[Successful treatment of adult Still's disease with tofacitinib in a HIV-2 positive female patient].
Topics: Adult; Female; HIV Infections; HIV-2; Humans; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Still's Disease, Adult-Onset; Treatment Outcome | 2020 |
Immune therapies in ulcerative colitis: are we beyond anti-TNF yet?
Topics: Antibodies, Monoclonal, Humanized; Colitis, Ulcerative; Comparative Effectiveness Research; Cost-Benefit Analysis; Dermatologic Agents; Humans; Piperidines; Placebos; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Safety; Treatment Outcome; Tumor Necrosis Factor-alpha; Ustekinumab | 2020 |
Tofacitinib-induced Ramsay- Hunt Syndrome in a Patient with Rheumatoid Arthritis.
Topics: Arthritis, Rheumatoid; Female; Herpes Zoster Oticus; Humans; Middle Aged; Piperidines; Pyrimidines; Pyrroles | 2021 |
Tofacitinib in Vogt-Koyanagi-Harada disease.
Topics: Humans; Piperidines; Pyrimidines; Pyrroles; Uveomeningoencephalitic Syndrome | 2020 |
Commentary: Janus kinase inhibitors and their use in autoimmune ocular inflammatory disorders.
Topics: Autoimmune Diseases; Humans; Janus Kinase Inhibitors; Piperidines; Pyrimidines; Pyrroles; Uveomeningoencephalitic Syndrome | 2020 |
Tofacitinib in recalcitrant scleritis: First case report from India.
Topics: Aged; Humans; Immunosuppressive Agents; India; Male; Piperidines; Pyrimidines; Pyrroles; Scleritis | 2020 |
Incidence Rates of Interstitial Lung Disease Events in Tofacitinib-Treated Rheumatoid Arthritis Patients: Post Hoc Analysis From 21 Clinical Trials.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Incidence; Lung Diseases, Interstitial; Piperidines; Pyrimidines; Pyrroles; Treatment Outcome | 2021 |
[Successful treatment of alopecia totalis with tofacitinib in a Danish patient].
Topics: Adult; Alopecia; Denmark; Humans; Male; Piperidines; Pyrimidines; Pyrroles | 2020 |
Lipid Profiles in Patients With Ulcerative Colitis Receiving Tofacitinib-Implications for Cardiovascular Risk and Patient Management.
Topics: Arthritis, Rheumatoid; Cardiovascular Diseases; Cholesterol; Clinical Trials, Phase III as Topic; Colitis, Ulcerative; Heart Disease Risk Factors; Humans; Inflammation; Lipids; Lipoproteins, HDL; Lipoproteins, LDL; Piperidines; Protein Kinase Inhibitors; Psoriasis; Pyrimidines; Pyrroles; Risk Factors; Treatment Outcome | 2021 |
Tofacitinib, the First Oral Janus Kinase Inhibitor Approved for Adult Ulcerative Colitis.
Topics: Adult; Colitis, Ulcerative; Humans; Janus Kinase Inhibitors; Piperidines; Pyrimidines; Pyrroles | 2021 |
Treatment of refractory anti-NXP2 and anti-TIF1γ dermatomyositis with tofacitinib.
Topics: Autoantibodies; Dermatomyositis; Humans; Piperidines; Pyrimidines; Pyrroles | 2021 |
Tofacitinib for recurrence of antimelanoma differentiation-associated gene 5 antibody-positive clinically amyopathic dermatomyositis after remission: A case report.
Topics: Autoantibodies; Dermatomyositis; Female; Humans; Interferon-Induced Helicase, IFIH1; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Recurrence | 2020 |
Lessons from tofacitinib in patients with cardiovascular risk factors: increased pulmonary embolism or isolated (thrombotic) pulmonary occlusion rates?
Topics: Arthritis, Psoriatic; Arthritis, Rheumatoid; Humans; Incidence; Piperidines; Psoriasis; Pulmonary Embolism; Pyrimidines; Pyrroles | 2020 |
Herpes Zoster in rheumatoid arthritis patients receiving tofacitinib, a single center experience from Taiwan.
Topics: Aged; Arthritis, Rheumatoid; Case-Control Studies; Female; Herpes Zoster; Humans; Incidence; Interferon-gamma; Lymphocyte Count; Male; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; T-Lymphocytes; Taiwan | 2020 |
Real-World Evidence to Contextualize Clinical Trial Results and Inform Regulatory Decisions: Tofacitinib Modified-Release Once-Daily vs Immediate-Release Twice-Daily for Rheumatoid Arthritis.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Medicare; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Treatment Outcome; United States | 2021 |
[Alopecia areata with good response to tofacitinib].
Topics: Alopecia; Alopecia Areata; Female; Humans; Middle Aged; Piperidines; Pyrimidines; Pyrroles | 2021 |
Real-World Effectiveness and Safety of Tofacitinib in Crohn's Disease and IBD-U: A Multicenter Study From the TROPIC Consortium.
Topics: Crohn Disease; Humans; Inflammatory Bowel Diseases; Piperidines; Pyrimidines; Pyrroles | 2021 |
Development of severe thrombocytopenia with TAFRO syndrome-like features in a patient with rheumatoid arthritis treated with a Janus kinase inhibitor: A case report.
Topics: Aged; Arthritis, Rheumatoid; Castleman Disease; Fatal Outcome; Female; Humans; Janus Kinase Inhibitors; Multiple Organ Failure; Piperidines; Pyrimidines; Pyrroles; Thrombocytopenia | 2020 |
TRPV4 channel blockade does not modulate skin vasodilation and sweating during hyperthermia or cutaneous postocclusive reactive and thermal hyperemia.
Topics: Adult; Female; Humans; Hyperemia; Hyperthermia; Leucine; Male; Membrane Transport Modulators; Microdialysis; Morpholines; Piperidines; Pyrroles; Quinolines; Regional Blood Flow; Skin; Sulfonamides; Sweating; Time Factors; TRPV Cation Channels; Vasodilation; Young Adult | 2021 |
Efficacy of systemic minoxidil and tofacitinib combination in treatment-resistant alopecia universalis.
Topics: Alopecia; Alopecia Areata; Humans; Minoxidil; Piperidines; Pyrimidines; Pyrroles | 2021 |
Refractory ulcerations associated with livedoid vasculopathy successfully treated with tofacitinib.
Topics: Humans; Livedo Reticularis; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Skin Diseases, Vascular; Skin Ulcer; Vascular Diseases | 2020 |
ICER's assessment of lasmiditan, rimegepant, and ubrogepant for acute migraine.
Topics: Benzamides; Humans; Migraine Disorders; Piperidines; Pyridines; Pyrroles | 2020 |
The effectiveness and value of novel acute treatments for migraine.
Topics: Analgesics; Benzamides; Calcitonin Gene-Related Peptide; Cost-Benefit Analysis; Drug Costs; Humans; Migraine Disorders; Piperidines; Pyridines; Pyrroles; Quality-Adjusted Life Years; Receptor, Serotonin, 5-HT1F; Receptors, Serotonin; Serotonin 5-HT1 Receptor Agonists; Signal Transduction; Systematic Reviews as Topic; Time Factors; Treatment Outcome | 2020 |
Good Response to Tofacitinib in Refractory Amyopathic Dermatomyositis.
Topics: Dermatomyositis; Humans; Piperidines; Pyrimidines; Pyrroles | 2021 |
Combined onabotulinumtoxinA/atogepant treatment blocks activation/sensitization of high-threshold and wide-dynamic range neurons.
Topics: Analgesics; Animals; Botulinum Toxins, Type A; Calcitonin; Humans; Migraine Disorders; Nerve Fibers, Unmyelinated; Piperidines; Pyridines; Pyrroles; Rats; Rats, Sprague-Dawley; Spiro Compounds | 2021 |
Pain Freedom at 2-8 Hours With Lasmiditan: A Comparison With Rimegepant and Ubrogepant: A Response.
Topics: Benzamides; Freedom; Humans; Pain; Piperidines; Pyridines; Pyrroles | 2020 |
CNS demyelination during tofacitinib therapy: First report.
Topics: Animals; Demyelinating Diseases; Humans; Piperidines; Pyrimidines; Pyrroles | 2020 |
Challenges of securing insurance approval for oral tofacitinib for the treatment of alopecia areata: a multi-institution retrospective review.
Topics: Aged; Alopecia Areata; Humans; Insurance; Medicare; Piperidines; Pyrimidines; Pyrroles; Quality of Life; Retrospective Studies; United States | 2022 |
Novel Piperidine and 3,4-dihydro-2H-pyrrole Alkaloids from Tilia platyphyllos and Tilia cordata Flowers.
Topics: Alkaloids; Flowers; Piperidines; Pyrroles; Tilia | 2021 |
Drug retention of sarilumab, baricitinib, and tofacitinib in patients with rheumatoid arthritis: the ANSWER cohort study.
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Azetidines; Cohort Studies; Female; Humans; Methotrexate; Middle Aged; Pharmaceutical Preparations; Piperidines; Purines; Pyrazoles; Pyrimidines; Pyrroles; Retrospective Studies; Sulfonamides; Treatment Outcome | 2021 |
Effects of one-year tofacitinib therapy on bone metabolism in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Bone Density; Humans; Piperidines; Pyrimidines; Pyrroles | 2021 |
Tofacitinib De-escalation Strategy in Ulcerative Colitis: Is It the End of the Story?
Topics: Colitis, Ulcerative; Humans; Piperidines; Pyrimidines; Pyrroles | 2021 |
Pediatric Game Changers∗: Oral tofacitinib for the treatment of alopecia areata in children.
Topics: Alopecia; Alopecia Areata; Child; Humans; Piperidines; Pyrimidines; Pyrroles | 2021 |
Alopecia areata flare patterns in children and young adults while on systemic tofacitinib.
Topics: Alopecia; Alopecia Areata; Child; Humans; Piperidines; Pyrimidines; Pyrroles; Young Adult | 2022 |
[Granulomatous rosacea-like dermatitis under therapy with tofacitinib].
Topics: Adult; Dermatitis; Female; Humans; Piperidines; Pyrimidines; Pyrroles; Rosacea | 2021 |
Clinical Efficacy of Tofacitinib in Moderate to Severe Ulcerative Colitis.
Topics: Colitis, Ulcerative; Humans; Piperidines; Pyrimidines; Pyrroles; Treatment Outcome | 2021 |
Selective inhibition of JAK3 signaling is sufficient to reverse alopecia areata.
Topics: Administration, Topical; Alopecia Areata; Animals; Azetidines; CD8-Positive T-Lymphocytes; Cytokines; Isonicotinic Acids; Janus Kinase 1; Janus Kinase 2; Janus Kinase 3; Macrophages; Mice, Inbred C3H; Nitriles; NK Cell Lectin-Like Receptor Subfamily K; Piperidines; Protein Kinase Inhibitors; Pyrazoles; Pyridines; Pyrimidines; Pyrroles; Triazoles | 2021 |
Development and evaluation of tofacitinib transdermal system for the treatment of rheumatoid arthritis in rats.
Topics: Administration, Cutaneous; Animals; Arthritis, Rheumatoid; Drug Delivery Systems; Piperidines; Pyrimidines; Pyrroles; Rats; Transdermal Patch | 2021 |
Topical tofacitinib for the treatment of alopecia areata affecting facial hair.
Topics: Administration, Topical; Alopecia; Alopecia Areata; Humans; Piperidines; Pyrimidines; Pyrroles | 2021 |
New Drugs 2021, Part 1.
Topics: Antibodies, Monoclonal, Humanized; Benzamides; Dicarboxylic Acids; Drug Approval; Fatty Acids; Heterocyclic Compounds, 4 or More Rings; Humans; Piperidines; Pyridines; Pyrimidines; Pyrroles; United States; United States Food and Drug Administration | 2021 |
Tofacitinib in Acute Severe Ulcerative Colitis: Case Series and a Systematic Review.
Topics: Colitis, Ulcerative; Humans; Piperidines; Pyrimidines; Pyrroles | 2021 |
Tofacitinib in Acute Severe Ulcerative Colitis: Case Series and a Systematic Review-Authors' Reply.
Topics: Colitis, Ulcerative; Humans; Piperidines; Pyrimidines; Pyrroles | 2021 |
Tofacitinib downregulates antiviral immune defence in keratinocytes and reduces T cell activation.
Topics: Antiviral Agents; Humans; Keratinocytes; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; T-Lymphocytes | 2021 |
The impact of body mass index on efficacy and safety in the tofacitinib OCTAVE ulcerative colitis clinical programme.
Topics: Body Mass Index; Colitis, Ulcerative; Humans; Piperidines; Pyrimidines; Pyrroles | 2021 |
Editorial: impact of body mass index on clinical outcomes in patients with ulcerative colitis treated with tofacitinib.
Topics: Body Mass Index; Colitis, Ulcerative; Humans; Piperidines; Pyrimidines; Pyrroles | 2021 |
To Probe the Binding Interactions between Two FDA Approved Migraine Drugs (Ubrogepant and Rimegepant) and Calcitonin-Gene Related Peptide Receptor (CGRPR) Using Molecular Dynamics Simulations.
Topics: Calcitonin Gene-Related Peptide; Humans; Migraine Disorders; Molecular Docking Simulation; Molecular Dynamics Simulation; Pharmaceutical Preparations; Piperidines; Pyridines; Pyrroles; Receptors, Calcitonin Gene-Related Peptide | 2021 |
A Case of Disseminated Cutaneous
Topics: Humans; Mycobacterium chelonae; Piperidines; Pyrimidines; Pyrroles | 2021 |
Editorial: is tofacitinib another rescue option for acute severe ulcerative colitis?
Topics: Colitis, Ulcerative; Humans; Piperidines; Pyrimidines; Pyrroles | 2021 |
Real-world comparative effectiveness and safety of tofacitinib and baricitinib in patients with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Azetidines; Humans; Piperidines; Purines; Pyrazoles; Pyrimidines; Pyrroles; Sulfonamides; Treatment Outcome | 2021 |
Adherence to treatment with tofacitinib in patients with rheumatoid arthritis in daily clinical practice.
Topics: Adolescent; Antirheumatic Agents; Arthritis, Rheumatoid; Cross-Sectional Studies; Female; Humans; Male; Middle Aged; Piperidines; Pyrimidines; Pyrroles | 2022 |
Letter: tofacitinib in biologic-experienced ulcerative colitis-a single-centre real-world experience in Australia.
Topics: Biological Products; Colitis, Ulcerative; Humans; Piperidines; Pyrimidines; Pyrroles | 2021 |
Letter: tofacitinib in treatment-refractory ulcerative colitis-a single centre real-world experience in Australia. Authors' reply.
Topics: Colitis, Ulcerative; Humans; Piperidines; Pyrimidines; Pyrroles | 2021 |
Blocking Jak/STAT signalling using tofacitinib inhibits angiogenesis in experimental arthritis.
Topics: Animals; Arthritis, Experimental; Endothelial Cells; Humans; Mice; Piperidines; Pyrimidines; Pyrroles; Synovial Membrane | 2021 |
Doubtful use of placebo following placebo in recent controlled trials of lasmiditan and ubrogepant for the treatment of migraine attacks.
Topics: Benzamides; Controlled Clinical Trials as Topic; Humans; Migraine Disorders; Piperidines; Pyridines; Pyrroles | 2022 |
5-ASAs Combined With a Biologic or Tofacitinib: Predetermined Cost-Effectiveness?
Topics: Biological Products; Cost-Benefit Analysis; Humans; Piperidines; Pyrimidines; Pyrroles | 2021 |
Granulomatous disease and the two faces of Janus: divergent effects of tofacitinib therapy for inflammatory arthritis.
Topics: Antirheumatic Agents; Arthritis; Humans; Janus Kinases; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Treatment Outcome | 2022 |
Tofacitinib inhibits CD4 T cell polarisation to Th1 during priming thereby leading to clinical impact in a model of experimental arthritis.
Topics: Animals; Arthritis, Experimental; CD4-Positive T-Lymphocytes; Janus Kinases; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles | 2022 |
Tofacitinib as an Adjunct Immunomodulator for Treatment of a Patient with Severe COVID-19: A Case Report.
Topics: COVID-19; Humans; Immunologic Factors; Piperidines; Pyrimidines; Pyrroles; SARS-CoV-2 | 2021 |
Systemic inflammatory responses after orthopedic surgery in patients with rheumatoid arthritis treated with tofacitinib.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Infant, Newborn; Orthopedic Procedures; Piperidines; Pyrimidines; Pyrroles; Retrospective Studies; Treatment Outcome | 2021 |
Tofacitinib for the treatment of rheumatoid arthritis: a real-world study in China.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; China; Humans; Piperidines; Pyrimidines; Pyrroles; Retrospective Studies; Treatment Outcome | 2022 |
Worldwide post-marketing safety surveillance experience with tofacitinib in ulcerative colitis.
Topics: Colitis, Ulcerative; Humans; Marketing; Piperidines; Pyrimidines; Pyrroles | 2022 |
Economic Benefit from Improvements in Quality of Life with Upadacitinib: Comparisons with Tofacitinib and Methotrexate in Patients with Rheumatoid Arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials, Phase III as Topic; Drug Therapy, Combination; Heterocyclic Compounds, 3-Ring; Humans; Methotrexate; Piperidines; Pyrimidines; Pyrroles; Quality of Life; Randomized Controlled Trials as Topic; Treatment Outcome | 2021 |
Alopecia areata and tofacitinib: a prospective multicenter study from a Saudi population.
Topics: Alopecia; Alopecia Areata; Humans; Piperidines; Prospective Studies; Pyrimidines; Pyrroles; Saudi Arabia; Treatment Outcome | 2022 |
Disseminated Tuberculosis in a Patient Treated with Tofacitinib for Ulcerative Colitis.
Topics: Colitis, Ulcerative; Humans; Piperidines; Pyrimidines; Pyrroles; Tuberculosis | 2022 |
Oral tofacitinib for the treatment of alopecia areata in pediatric patients.
Topics: Adolescent; Alopecia; Alopecia Areata; Child; Female; Humans; Male; Piperidines; Pyrimidines; Pyrroles; Retrospective Studies; Treatment Outcome | 2022 |
Safety and efficacy of tofacitinib for treatment of ulcerative colitis: final analysis of OCTAVE Open, an open-label, long-term extension study with up to 7.0 years of treatment.
Topics: Colitis, Ulcerative; Humans; Piperidines; Pyrimidines; Pyrroles; Treatment Outcome | 2022 |
Atogepant.
Topics: Analgesics; Humans; Migraine Disorders; Piperidines; Pyridines; Pyrroles; Spiro Compounds | 2022 |
Alkaloids from Lime Flower (Tiliae flos) Exert Spasmodic Activity on Murine Airway Smooth Muscle Involving Acetylcholinesterase.
Topics: Acetylcholinesterase; Alkaloids; Animals; Caco-2 Cells; Cholinesterase Inhibitors; Flowers; Galantamine; Humans; Mice; Muscle, Smooth; Piperidines; Pyrroles | 2022 |
Tofacitinib as a pragmatic treatment choice for alopecia areata: A retrospective review.
Topics: Alopecia; Alopecia Areata; Humans; Piperidines; Pyrimidines; Pyrroles; Retrospective Studies | 2022 |
Atogepant (Qulipta) for migraine prevention.
Topics: Administration, Oral; Calcitonin Gene-Related Peptide Receptor Antagonists; Drug Interactions; Humans; Migraine Disorders; Piperidines; Pyridines; Pyrroles; Receptors, Calcitonin Gene-Related Peptide; Signal Transduction; Spiro Compounds; Treatment Outcome | 2021 |
Effectiveness of baricitinib and tofacitinib compared with bDMARDs in RA: results from a cohort study using nationwide Swedish register data.
Topics: Abatacept; Antirheumatic Agents; Arthritis, Rheumatoid; Azetidines; Biological Products; Cohort Studies; Humans; Interleukin-6; Piperidines; Purines; Pyrazoles; Pyrimidines; Pyrroles; Rituximab; Sulfonamides; Sweden; Treatment Outcome; Tumor Necrosis Factor Inhibitors | 2022 |
Time to response for clinical and patient-reported outcomes in patients with psoriatic arthritis treated with tofacitinib, adalimumab, or placebo.
Topics: Adalimumab; Antirheumatic Agents; Arthritis, Psoriatic; Humans; Patient Reported Outcome Measures; Piperidines; Pyrimidines; Pyrroles; Treatment Outcome | 2022 |
Persistence of treatment in patients with ulcerative colitis who responded to tofacitinib therapy: data from the open-label, long-term extension study, OCTAVE open.
Topics: Colitis, Ulcerative; Humans; Longitudinal Studies; Piperidines; Pyrimidines; Pyrroles | 2022 |
Work productivity in rheumatoid arthritis patients from two Latin American countries treated with tofacitinib or biological DMARDs.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Efficiency; Humans; Latin America; Piperidines; Pyrimidines; Pyrroles; Treatment Outcome; Work Performance | 2022 |
Refractory alopecia universalis associated with dermatomyositis successfully treated with tofacitinib.
Topics: Adult; Alopecia; Alopecia Areata; Dermatomyositis; Female; Humans; Interferons; Piperidines; Pyrimidines; Pyrroles | 2022 |
Topical Janus kinase-signal transducers and activators of transcription inhibitor tofacitinib is effective in reducing nonatopic dermatitis chronic itch: A case series.
Topics: Dermatitis; Humans; Janus Kinases; Piperidines; Pruritus; Pyrimidines; Pyrroles | 2022 |
Atogepant: an emerging treatment for migraine.
Topics: Adult; Antibodies, Monoclonal; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Humans; Migraine Disorders; Piperidines; Pyridines; Pyrroles; Spiro Compounds | 2022 |
Atogepant - an orally-administered CGRP antagonist - attenuates activation of meningeal nociceptors by CSD.
Topics: Animals; Bayes Theorem; Calcitonin Gene-Related Peptide; Male; Migraine Disorders; Nerve Fibers, Unmyelinated; Nociceptors; Piperidines; Pyridines; Pyrroles; Rats; Rats, Sprague-Dawley; Spiro Compounds | 2022 |
Elucidating the structure and cytochrome P450-mediated mechanism for novel metabolites of GDC-0575 in rats.
Topics: Animals; Cytochrome P-450 Enzyme System; Glutathione; Microsomes, Liver; Piperidines; Pyridines; Pyrroles; Rats | 2022 |
Comparison of cardiovascular, cancer and herpes zoster risk of tofacitinib versus etanercept: single-centre observational study.
Topics: Etanercept; Herpes Zoster; Herpesvirus 3, Human; Humans; Neoplasms; Piperidines; Pyrimidines; Pyrroles | 2022 |
Atogepant (Qulipta®) for migraine prevention.
Topics: Analgesics; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Humans; Migraine Disorders; Piperidines; Pyridines; Pyrroles; Spiro Compounds | 2022 |
Tofacitinib therapy for alopecia areata is not associated with adverse events during COVID-19 infection.
Topics: Alopecia; Alopecia Areata; COVID-19; Humans; Piperidines; Pyrroles | 2023 |
Comparing the Liver Safety Profiles of 4 Next-Generation CGRP Receptor Antagonists to the Hepatotoxic CGRP Inhibitor Telcagepant Using Quantitative Systems Toxicology Modeling.
Topics: Azepines; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Chemical and Drug Induced Liver Injury; Computer Simulation; Drug-Related Side Effects and Adverse Reactions; Humans; Imidazoles; Piperidines; Pyridines; Pyrroles; Spiro Compounds | 2022 |
Tailoring Tofacitinib Oral Therapy in Rheumatoid Arthritis: The TuTOR App.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Mobile Applications; Piperidines; Pyrimidines; Pyrroles; Treatment Outcome | 2022 |
Tofacitinib for Treatment of Alopecia Areata: Real-world Evidence and Factors Associated with Therapeutic Response.
Topics: Alopecia; Alopecia Areata; Humans; Piperidines; Pyrimidines; Pyrroles | 2022 |
Real-world evidence of the effectiveness and safety of generic tofacitinib in rheumatoid arthritis patients: a retrospective, single-centre analysis from Western India.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; COVID-19; Female; Humans; India; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Retrospective Studies; Treatment Outcome | 2022 |
Safety and efficacy of long-term tofacitinib treatment in East Asian patients with ulcerative colitis in OCTAVE Open.
Topics: Colitis, Ulcerative; Humans; Janus Kinase Inhibitors; Piperidines; Pyrimidines; Pyrroles; Treatment Outcome | 2022 |
Characterization of transit rates in the large intestine of mice following treatment with a CGRP antibody, CGRP receptor antibody, and small molecule CGRP receptor antagonists.
Topics: Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Charcoal; Constipation; Female; Humans; Intestine, Large; Ligands; Male; Mice; Mice, Transgenic; Piperidines; Pyridines; Pyrroles; Receptor Activity-Modifying Protein 1; Receptors, Calcitonin Gene-Related Peptide; Spiro Compounds | 2022 |
Oral tofacitinib for successful treatment of refractory alopecia areata in preschool children.
Topics: Alopecia; Alopecia Areata; Child, Preschool; Humans; Piperidines; Pyrimidines; Pyrroles | 2022 |
[What do the results of the ORAL surveillance study mean for the treatment of rheumatoid arthritis with tofacitinib?]
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Reproducibility of Results; Treatment Outcome | 2022 |
Tofacitinib as a possible treatment for arthritis in an APDS2 patient.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Treatment Outcome | 2023 |
Atogepant for migraine.
Topics: Analgesics; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Humans; Migraine Disorders; Piperidines; Pyridines; Pyrroles; Spiro Compounds | 2022 |
A Retrospective Review of Tofacitinib in the Treatment of Refractory Dermatomyositis.
Topics: Dermatomyositis; Humans; Immunologic Factors; Piperidines; Pyrimidines; Pyrroles; Retrospective Studies; Treatment Outcome | 2022 |
Tofacitinib for sarcoidosis, a new potential treatment.
Topics: Humans; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Sarcoidosis | 2022 |
Tofacitinib in Ulcerative Colitis-evolving Efficacy and Safety.
Topics: Colitis, Ulcerative; Humans; Piperidines; Pyrimidines; Pyrroles | 2023 |
Letter: tofacitinib in the real world - do clinical trial data stand up?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Piperidines; Pyrimidines; Pyrroles | 2023 |