pyrroles has been researched along with phenyl acetate in 158 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 30 (18.99) | 18.7374 |
| 1990's | 15 (9.49) | 18.2507 |
| 2000's | 77 (48.73) | 29.6817 |
| 2010's | 31 (19.62) | 24.3611 |
| 2020's | 5 (3.16) | 2.80 |
| Authors | Studies |
|---|---|
| Boyle, E; Freeman, PC; Goudie, AC; Mangan, FR; Thomson, M | 1 |
| Bertelli, A; Schinetti, ML | 1 |
| Demopoulos, VJ; Rekka, E; Retsas, S | 1 |
| Ackerman, N; Ballaron, SA; Galeazzi, E; Greenhouse, R; Guzmán, A; Muchowski, JM; Peréz, V; Rovito, JR; Tomolonis, AJ; Young, JM | 1 |
| Campbell, RL; Giglio, JA | 1 |
| Ellis, E; Scott, R; Upton, LG | 1 |
| Dannhardt, G; Lehr, M | 1 |
| Dannhardt, G; Steindl, L | 1 |
| Albuquerque, EX; Sansone, FM; Warnick, JE | 1 |
| Friedrich, W; Moskophidis, M | 1 |
| Ogata, M; Tomokuni, K | 1 |
| Carson, JR; Wong, S | 1 |
| Frydman, B; Frydman, RB; Valasinas, A | 1 |
| Komatsu, Y | 1 |
| Achtari, H; Goldenberg, B; Revaz, C | 1 |
| Arndt, DJ; Konigsberg, W | 1 |
| Daly, JW; Johnson, DF | 1 |
| Gössinger, FE; Graf, W; Imhof, R; Schnüriger, W; Wehrli, H | 1 |
| Carson, JR; McKinstry, DN; Wong, S | 1 |
| Baba, A; Sawamura, R | 1 |
| Cederbaum, S; Kung, HF; Stadtman, TC; Tsai, L | 1 |
| Huisgen, R; Knorr, R | 1 |
| Mannervik, B; Sörbo, B | 1 |
| Bernlohr, RW; Laishley, EJ | 1 |
| Davies, JL | 1 |
| Berhauer, K; Vogelmann, H; Wagner, F | 1 |
| Jensen, B | 1 |
| Cole, WJ; Krueger, WR; Moscowitz, A; O hEocha, C | 1 |
| Khor, E; Li, HC; Wee, A | 1 |
| Diop, L; Junien, JL; Langlois, A; Pascaud, X; Rivière, PJ | 1 |
| Carter, L; Laufer, S; McKnight, W; Tries, S; Wallace, JL | 1 |
| Algate, DR; Atterson, PR; Augustin, J; Beard, DJ; Jobling, CM; Laufer, S; Munt, PL; Tries, S | 1 |
| Deigner, HP; Freyberg, CE; Laufer, S | 1 |
| Augustin, J; Heidemann, A; Laufer, S; Tries, S | 1 |
| Algate, DR; Atterson, PR; Augustin, J; Elsässer, R; Laufer, S; Munt, PL; Tries, S | 1 |
| Albrecht, W; Algate, DR; Atterson, PR; Augustin, J; Elsässer, R; Guserle, R; Laufer, S; Munt, PL; Tries, S | 1 |
| Augustin, J; Dannhardt, G; Kiefer, W; Laufer, SA | 1 |
| Augustin, J; Dannhardt, G; Laufer, S; Tries, S | 1 |
| Cann, IK; Hoshino, S; Kobayashi, Y; Onoda, A; Wakita, M | 1 |
| Kawamura, N; Naganawa, H; Sawa, R; Sawa, T; Takahashi, Y; Takeuchi, T | 1 |
| Claus, R; Deigner, HP; Fyrnys, B; Wolf, G | 1 |
| Abraham, WM; Laufer, S; Tries, S | 1 |
| Gilbertson, SR; Lan, P | 1 |
| Gay, RE; Gay, S; Laufer, S; Neidhart, M; Pataky, F; Tries, S | 1 |
| Fernandes, JC; Jolicoeur, FC; Jovanovic, DV; Laufer, S; Martel-Pelletier, J; Pelletier, JP; Reboul, P; Tries, S | 1 |
| Doyle, MP; Hu, W; Timmons, DJ | 1 |
| Breddin, HK; Laufer, S; Radziwon, P; Tries, S | 1 |
| Laufer, S; Neupert, W; Tries, S | 1 |
| Lajeunesse, D; Laufer, S; Martel-Pelletier, J; Massicotte, F; Paredes, Y; Pelletier, JP | 1 |
| Boileau, C; Jouzeau, JY; Laufer, S; Martel-Pelletier, J; Moldovan, F; Netter, P; Pelletier, JP; Tries, S | 1 |
| Anagnostou, C; Demopoulos, VJ; Nicolaou, I | 1 |
| Alegret, M; Díaz, C; Hernández, G; Jové, M; Laguna, JC; Llaverías, G; Sánchez, RM; Vázquez-Carrera, M | 1 |
| Cerletti, C; Dell'Elba, G; Evangelista, V; Krauze-Brzósko, K; Manarini, S; Martelli, N; Pecce, R; Rotondo, S | 1 |
| Demopoulos, VJ; Nicolaou, I | 1 |
| Doyle, MP; Gronenberg, LS; Hu, W; Yan, M | 1 |
| Barbanti, M; de Lima, OM; Distrutti, E; Fiorucci, S; Mencarelli, A; Morelli, A; Palazzini, E; Romano, M; Wallace, JL | 1 |
| Hawkey, CJ; Skelly, MM | 1 |
| Laufer, S | 1 |
| Evans, R | 1 |
| Cirino, G; Distrutti, E; Fiorucci, S; Laufor, SA; Mencarelli, A; Morelli, A; Wallace, JL | 1 |
| Cicuttini, F; Ding, C | 1 |
| BOSSENMAIER, I; TADDEINI, L; WATSON, CJ | 1 |
| BESSMAN, SP; GOOD, TA | 1 |
| BIANCHI, MR; BOCCACCI, M; MISITI-DORELLO, P; QUINTILIANI, M | 1 |
| Celotti, F; Durand, T | 1 |
| Akçamur, Y; Akkurt, M; Fun, HK; Oztürk, S; Saçmaci, M; Ungören, H | 1 |
| Heinonen, T; Klepack, E; Lovalvo, J; Marais, AD; McLain, R; Raal, FJ | 1 |
| Fernandes, JC; Lajeunesse, D; Laufer, S; Martel-Pelletier, J; Pelletier, JP | 1 |
| Bannwarth, B | 1 |
| Brune, K | 1 |
| Alvaro-Gracia, JM | 1 |
| Boileau, C; Boily, M; Brunet, J; Lajeunesse, D; Laufer, S; Martel-Pelletier, J; Pelletier, JP; Reboul, P | 1 |
| Goldenring, JR; Gupta, S; Hammond, CE; Smolka, AJ | 1 |
| Cerletti, C; Evangelista, V; Krauze-Brzósko, K; Manarini, S; Rotondo, S | 1 |
| Arefrad, H; Azizian, J; Karimi, AR; Mohammadi, AA; Mohammadizadeh, MR | 1 |
| Bias, P; Buchner, A; Klesser, B; Laufer, S | 1 |
| Al-awar, RS; Clayton, MT; Coffey, DS; Engler, TA; Faul, MM; Furness, K; Grutsch, JL; Kolis, SP; LeTourneau, M; Malhotra, S; Martinelli, MJ; Pawlak, JM; Pedersen, SW; Ray, JE; Sullivan, KA | 1 |
| Demopoulos, VJ; Nicolaou, I; Zika, C | 1 |
| Boileau, C; Fahmi, H; Laufer, S; Lavigne, M; Martel-Pelletier, J; Pelletier, JP; Tardif, G | 1 |
| Daminet, S; Fernandes, J; Martel-Pelletier, J; Moreau, M; Pelletier, JP | 1 |
| Guévremont, M; Laufer, S; Marcouiller, P; Martel-Pelletier, J; Pelletier, JP; Ranger, P; Reboul, P | 1 |
| Kulkarni, SK; Patil, CS; Singh, VP | 2 |
| Naveau, B | 1 |
| Anzini, M; Biava, M; Botta, M; Cappelli, A; Makovec, F; Manetti, F; Porretta, GC; Rossi, A; Sautebin, L; Vomero, S | 1 |
| Albrecht, W; Dannhardt, G; Eriksson, EE; Laufer, S; Lindbom, L; Soehnlein, O; Ulbrich, H; Xie, X | 1 |
| Cicero, AF; Derosa, G; Gaddi, A | 1 |
| Boileau, C; Boily, M; Brunet, J; Geng, C; Lajeunesse, D; Laufer, S; Martel-Pelletier, J; Mineau, F; Pelletier, JP; Reboul, P | 1 |
| Hashimoto, T; Kano, T; Maruoka, K | 1 |
| Boileau, C; Brunet, J; Laufer, S; Martel-Pelletier, J; Moreau, M; Pelletier, JP | 1 |
| Cerletti, C; Dell'Elba, G; Evangelista, V; Manarini, S; Rotondo, S | 1 |
| Ito, Y; Maeda, H | 1 |
| Egido, J; Gómez-Gerique, JA; Gómez-Hernández, A; González, A; Ortega, L; Sánchez-Galán, E; Tuñón, J; Vidal, C | 1 |
| Arderiu, G; Escolar, G; Hernandez, MR; Pedreño, J; Pino, M; Salas, E; Serradell, M; Tonda, R | 1 |
| Hampton, T | 1 |
| Jang, J; Ko, S | 1 |
| Håberg, A; Hjelstuen, MH; Qu, H; Sonnewald, U | 1 |
| Kulkarni, SK; Singh, VP | 1 |
| Bonne, D; Dekhane, M; Zhu, J | 1 |
| Sibi, MP; Soeta, T; Stanley, LM | 1 |
| Doucet, M; Lussier, B; Martel-Pelletier, J; Moreau, M; Pelletier, JP; Vincent, G | 1 |
| Benedetto, AD; Calvano, CD; Colaianni, G; Colucci, S; Cometa, S; De Giglio, E; Sabbatini, L; Zambonin, PG | 1 |
| Gay, RE; Gay, S; Kurowska-Stolarska, M; Laufer, S; Michel, BA; Neidhart, M; Ospelt, C | 1 |
| Dodt, G; Fischer, L; Franke, L; Hornig, M; Meindl, N; Pergola, C; Schneider, G; Steinhilber, D; Tanrikulu, Y; Werz, O | 1 |
| El-Desouky, SK; Eweas, AF; Gamal-Eldeen, AM; Kim, KH; Kim, YK; Ryu, SY | 1 |
| Anzellotti, P; Anzini, M; Biava, M; Botta, M; Cappelli, A; Forli, S; Ghelardini, C; Makovec, F; Manetti, F; Patrignani, P; Pergola, C; Poce, G; Porretta, GC; Rossi, A; Rovini, M; Sautebin, L; Supino, S; Vivoli, E | 1 |
| Martel-Pelletier, J; Pelletier, JP | 1 |
| Coruzzi, G; Spaggiari, S; Venturi, N | 1 |
| Bartolini, G; Bonafè, M; Brighenti, E; Ferreri, C; Guarnieri, T; Laufer, S; Manara, S; Marini, M; Tavolari, S; Tomasi, V | 1 |
| Cicero, AF; Laghi, L | 1 |
| Budoff, MJ; Gao, YL; Kessler, P; Mao, SS; Moustafa, M; Qunibi, W | 1 |
| Albrecht, W; Laufer, S; Nussler, AK; Unger, A | 1 |
| Badimon, JJ; Chew, DP; Corti, R; Fallon, JT; Fayad, ZA; Fuster, V; Helft, G; Worthley, MI; Worthley, SG; Zaman, AG | 1 |
| Budoff, M; Diaz-Buxo, JA; He, DY; Kessler, PD; Moustafa, M; Muenz, LR; Qunibi, W | 1 |
| Fawcett, JP; Gu, J; Jiang, Y; Kong, J; Tang, Y; Teng, G; Wang, J; Wang, Y | 1 |
| Baumgardt, I; Butenschön, H; Cao, W; Erden, I; Gärtner, C; Hoarau, C; Ozer, G; Song, J | 1 |
| Cheng, S; Ge, S; Liu, D; Liu, X; Xu, G; Xu, J; Zhou, G | 1 |
| Hawkins, JM; Hettenbach, KW; Larrivée-Aboussafy, C; Lillie, BM; McLaughlin, RW; Mustakis, J; Price, KE; Vaidyanathan, R | 1 |
| Armstrong, DW; Breitbach, ZS; Colyer, CL; Gerardi, AR; Lin, X | 1 |
| Chrysanthakopoulos, M; Demopoulos, VJ; Nicolaou, I; Tsantili-Kakoulidou, A | 1 |
| Cheng, S; Ge, S; Liu, D; Liu, X; Liu, Z; Xu, G; Zhang, R; Zhou, G; Zhu, W | 1 |
| Chen, L; Hao, L; Lin, M; Liu, XT; Zhan, ZP | 1 |
| Dömling, A; Wang, K | 1 |
| Cui, Y; Fan, A; Jia, Y; Li, Q; Lin, W; Lu, Z | 1 |
| Elliott, M; Goulder, M; Hislop, C; Rosenson, RS; Stasiv, Y; Waters, D | 1 |
| Aginagalde, M; Arrieta, A; Bello, T; Cossío, FP; Masdeu, C; Vara, Y | 1 |
| Iwai, K; Kitoh, M; Maruta, K; Nagamine, J; Nagata, R; Taiji, M; Tsuchida, A; Ushiroda, K | 1 |
| Rosenson, RS | 1 |
| Abibi, A; Bettencourt, B; Bonafoux, D; Burchat, A; Ericsson, A; Harris, CM; Kebede, T; McPherson, M; Morytko, M; Wallace, G; Wu, X | 1 |
| Bando, T; Hashiya, K; Morinaga, H; Sugiyama, H; Takagaki, T; Yamamoto, M | 1 |
| Fraser, H; Goulder, MA; Hislop, C; Rosenson, RS | 1 |
| Alfonso, S; Anzellotti, P; Anzini, M; Battilocchio, C; Biava, M; Bruno, A; Calderone, V; Di Cesare Mannelli, L; Ghelardini, C; Giordani, A; Giorgi, G; Martelli, A; Papa, G; Patrignani, P; Poce, G; Porretta, GC; Rossi, A; Rovini, M; Sautebin, L; Testai, L; Valenti, S | 1 |
| Li, S; Luo, Y; Wu, J; Zheng, D | 1 |
| Bash, D; Cavender, MA; Hislop, C; Kastelein, JJ; Nicholls, SJ; Rosenson, RS; Schwartz, G; Waters, DD | 1 |
| Choi, YJ; Geaney, JC; Karpf, DB; Krauss, RM; Naim, S; Roberts, BK; Wang, X; Wojnoonski, K | 1 |
| Pettipher, R; Whittaker, M | 1 |
| Reddy, CR; Reddy, MD; Srikanth, B | 1 |
| Bergander, K; Dolovanyuk, VG; Fröhlich, R; Gerus, II; Haufe, G; Kondratov, IS; Tolmachova, NA | 1 |
| Basmadjian, C; Buzard, D; Gharbaoui, T; Johnson, BR; Jones, RM; Kasem, M; Lopez, L; Schrader, TO; Sengupta, D | 1 |
| Chen, T; Shao, N; Zhu, H; Zou, H | 1 |
| Huang, L; Jiang, H; Qi, C; Tang, X; Wu, W | 1 |
| Bash, D; Brennan, DM; Cavender, MA; Jukema, JW; Kastelein, JJ; Koenig, W; Lincoff, AM; Menon, V; Nambi, V; Nicholls, SJ; Nissen, SE; Rosenson, RS; Schwartz, GG; Wright, RS | 1 |
| He, T; Loh, TP; Xu, YH; Zhang, QC | 1 |
| Kinoshita, K; Namba, K; Yoshida, M | 1 |
| Dong, D; Han, F; Liang, Y; Liu, X; Xin, X; Zhang, D; Zhang, R | 1 |
| Bruchim, I; Flescher, E; Reiss, A; Sarfstein, R; Werner, H | 1 |
| Basireddy, VS; Dharmarajan, S; Guttala, RS; Jagarlamudi, PS; Mukkara, LD; Pagadala, LR; Perumal, Y; Ravirala, N; Singh, A; Singireddi, S; Thummaluru, VR; Ummanni, R; Upadhyayula, SM | 1 |
| Adamo, MF; Disetti, P; Moccia, M; Salazar Illera, D; Suresh, S | 1 |
| Fu, J; Liu, L; Wang, LP; Xiu, ZM; Xu, J | 1 |
| Almeida, RG; Baiju, TV; Brito, LM; Cavalcanti, BC; da Silva Júnior, EN; de Simone, CA; Namboothiri, INN; Pessoa, C; Sivanandan, ST | 1 |
| Adlin Jenifer, JSC; Citarasu, T; Eswaramoorthy Thirumalaikumar, CL; Jeraldin Nisha, SR; Michaelbabu, M; Uma, G | 1 |
| Aoyagi, H; Hirasawa, N; Kajiwara, D; Miyoshi, K; Tanaka, K; Tsunekuni, K | 1 |
| Konishi, T; Matsugo, S; Nakamura, Y; Nishida, A; Sakamoto, T; Sato, S; Wada, N | 1 |
| Adhoum, N; Catak, D; Moncer, F; Monser, L | 1 |
| Sun, Z; Zhou, L | 1 |
| Chen, XH; Cui, HL; Li, WZ; Wang, ZD; Zhang, W | 1 |
13 review(s) available for pyrroles and phenyl acetate
| Article | Year |
|---|---|
ML 3000.
Topics: Acetates; Animals; Clinical Trials as Topic; Drug Industry; Humans; Lung Diseases, Obstructive; Pyrroles; Rheumatic Diseases | 2002 |
COX-LOX inhibition: current evidence for an emerging new therapy.
Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arthritis; Clinical Trials, Phase III as Topic; Cyclooxygenase Inhibitors; Dogs; Humans; Intestinal Mucosa; Leukotrienes; Lipoxygenase Inhibitors; Models, Animal; Peptic Ulcer; Prostaglandins; Pyrroles; Rats; Sheep | 2003 |
Licofelone (Merckle).
Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Cyclooxygenase Inhibitors; Humans; Inflammation; Lipoxygenase Inhibitors; Osteoarthritis; Pyrroles; Structure-Activity Relationship | 2003 |
The metabolic effects of inhibitors of 5-lipoxygenase and of cyclooxygenase 1 and 2 are an advancement in the efficacy and safety of anti-inflammatory therapy.
Topics: Acetates; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Cardiovascular System; Clinical Trials, Phase III as Topic; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Humans; Intestinal Mucosa; Isoenzymes; Leukotrienes; Lipoxygenase Inhibitors; Membrane Proteins; Naproxen; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Pyrroles | 2003 |
Is licofelone, a dual inhibitor of cyclo-oxygenase and 5-lipoxygenase, a promising alternative in anti-inflammatory therapy?
Topics: Acetates; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents; Arachidonate 5-Lipoxygenase; Clinical Trials as Topic; Cyclooxygenase Inhibitors; Digestive System; Eicosanoids; Humans; Kidney Function Tests; Lipoxygenase Inhibitors; Osteoarthritis; Prostaglandin-Endoperoxide Synthases; Pyrroles; Randomized Controlled Trials as Topic | 2004 |
Safety of anti-inflammatory treatment--new ways of thinking.
Topics: Acetates; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Progression; Gastrointestinal Diseases; Humans; Isoenzymes; Membrane Proteins; Osteoarthritis; Prostaglandin-Endoperoxide Synthases; Pyrroles | 2004 |
Licofelone--clinical update on a novel LOX/COX inhibitor for the treatment of osteoarthritis.
Topics: Acetates; Aspirin; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Combinations; Gastrointestinal Diseases; Humans; Isoenzymes; Lipoxygenase Inhibitors; Long-Term Care; Membrane Proteins; Osteoarthritis; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Pyrroles; Sulfonamides | 2004 |
Combined lipoxygenase/cyclo-oxygenase inhibition in the elderly: the example of licofelone.
Topics: Acetates; Aged; Animals; Clinical Trials as Topic; Comorbidity; Cyclooxygenase Inhibitors; Humans; Lipoxygenase Inhibitors; Pyrroles | 2005 |
Licofelone--a novel analgesic and anti-inflammatory agent.
Topics: Acetates; Analgesics; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Cyclooxygenase Inhibitors; Humans; Lipoxygenase Inhibitors; Pyrroles | 2007 |
DMOAD developments: present and future.
Topics: Acetates; Anthraquinones; Antirheumatic Agents; Chondroitin; Clinical Trials as Topic; Diphosphonates; Disease Progression; Doxycycline; Glucosamine; Humans; Hyaluronic Acid; Matrix Metalloproteinase Inhibitors; Osteoarthritis; Pyrroles; Risk Factors | 2007 |
Gastrointestinal safety of novel nonsteroidal antiinflammatory drugs: selective COX-2 inhibitors and beyond.
Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Colon; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Gastric Mucosa; Gastrointestinal Tract; Humans; Hydrogen Sulfide; Lipoxins; Lipoxygenase Inhibitors; Nitric Oxide; Nitric Oxide Donors; Protein Isoforms; Pyrroles; Safety | 2007 |
Activity and potential role of licofelone in the management of osteoarthritis.
Topics: Acetates; Humans; Lipoxygenase Inhibitors; Osteoarthritis; Pyrroles; Treatment Outcome | 2007 |
Update on the development of antagonists of chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2). From lead optimization to clinical proof-of-concept in asthma and allergic rhinitis.
Topics: Acetates; Animals; Asthma; Aza Compounds; Carbazoles; Clinical Trials as Topic; Humans; Indoleacetic Acids; Pyrazoles; Pyrimidines; Pyrroles; Receptors, Immunologic; Receptors, Prostaglandin; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Sulfonamides; Th2 Cells; Thiazoles | 2012 |
14 trial(s) available for pyrroles and phenyl acetate
| Article | Year |
|---|---|
Comparison of etodolac, zomepirac, and placebo for relief of pain after oral surgery.
Topics: Acetates; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Double-Blind Method; Etodolac; Female; Humans; Male; Middle Aged; Molar, Third; Pain, Postoperative; Placebos; Pyrroles; Random Allocation; Time Factors; Tolmetin; Tooth Extraction | 1986 |
Double-blind evaluation of etodolac (200 mg, 400 mg) compared with zomepirac (100 mg) and placebo on third molar extraction pain.
Topics: Acetates; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Double-Blind Method; Etodolac; Humans; Middle Aged; Molar, Third; Pain Measurement; Pain, Postoperative; Pyrroles; Random Allocation; Tolmetin; Tooth Extraction | 1986 |
Avasimibe, an ACAT inhibitor, enhances the lipid lowering effect of atorvastatin in subjects with homozygous familial hypercholesterolemia.
Topics: Acetamides; Acetates; Administration, Oral; Adolescent; Adult; Age Factors; Atorvastatin; Child; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Synergism; Drug Therapy, Combination; Enzyme Inhibitors; Female; Follow-Up Studies; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipoproteinemia Type II; Lipoproteins, HDL; Lipoproteins, LDL; Male; Middle Aged; Multivariate Analysis; Probability; Pyrroles; Reference Values; Risk Assessment; Severity of Illness Index; Sex Factors; Sterol O-Acyltransferase; Sterol O-Acyltransferase 2; Sulfonamides; Sulfonic Acids; Treatment Outcome | 2003 |
The gastrointestinal tolerability of the LOX/COX inhibitor, licofelone, is similar to placebo and superior to naproxen therapy in healthy volunteers: results from a randomized, controlled trial.
Topics: Acetates; Adult; Cyclooxygenase Inhibitors; Duodenoscopy; Duodenum; Female; Gastric Mucosa; Gastroscopy; Humans; Incidence; Intestinal Mucosa; Lipoxygenase Inhibitors; Male; Naproxen; Peptic Ulcer; Pyrroles | 2004 |
Superiority of the gastroduodenal safety profile of licofelone over rofecoxib, a COX-2 selective inhibitor, in dogs.
Topics: Acetates; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Dogs; Double-Blind Method; Duodenoscopy; Duodenum; Gastroscopy; Lactones; Lipoxygenase Inhibitors; Pyrroles; Stomach; Sulfones; Treatment Outcome | 2005 |
Efficacy of licofelone in dogs with clinical osteoarthritis.
Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dog Diseases; Dogs; Double-Blind Method; Female; Gait; Lameness, Animal; Male; Osteoarthritis; Pyrroles | 2007 |
The interscan variation of CT coronary artery calcification score: analysis of the Calcium Acetate Renagel Comparison (CARE)-2 study.
Topics: Acetates; Atorvastatin; Calcinosis; Calcium Compounds; Chelating Agents; Coronary Artery Disease; Disease Progression; Drug Therapy, Combination; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney Failure, Chronic; Male; Middle Aged; Polyamines; Prospective Studies; Pyrroles; Reproducibility of Results; Sevelamer; Tomography, X-Ray Computed; Treatment Outcome | 2008 |
A 1-year randomized trial of calcium acetate versus sevelamer on progression of coronary artery calcification in hemodialysis patients with comparable lipid control: the Calcium Acetate Renagel Evaluation-2 (CARE-2) study.
Topics: Acetates; Anticholesteremic Agents; Atorvastatin; Calcinosis; Calcium Compounds; Chelating Agents; Coronary Artery Disease; Disease Progression; Female; Heptanoic Acids; Humans; Male; Middle Aged; Polyamines; Prospective Studies; Pyrroles; Renal Dialysis; Sevelamer; Time Factors | 2008 |
Effects of varespladib methyl on biomarkers and major cardiovascular events in acute coronary syndrome patients.
Topics: Acetates; Acute Coronary Syndrome; Aged; Atorvastatin; Biomarkers; C-Reactive Protein; Cholesterol, LDL; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Follow-Up Studies; Heptanoic Acids; Humans; Indoles; Keto Acids; Logistic Models; Male; Middle Aged; Phospholipases A2, Secretory; Prospective Studies; Pyrroles; Reference Values; Treatment Outcome | 2010 |
After FRANCIS: next steps in the clinical evaluation of varespladib methyl.
Topics: Acetates; Acute Coronary Syndrome; Analysis of Variance; Anticholesteremic Agents; Atorvastatin; Biomarkers; C-Reactive Protein; Cholesterol, LDL; Endothelium, Vascular; Female; Heptanoic Acids; Humans; Hyperlipidemias; Indoles; Keto Acids; Logistic Models; Male; Middle Aged; Phospholipases A2, Secretory; Pyrroles | 2011 |
Anti-inflammatory effects of varespladib methyl in diabetic patients with acute coronary syndrome.
Topics: Acetates; Acute Coronary Syndrome; Anti-Inflammatory Agents; Atorvastatin; Biomarkers; C-Reactive Protein; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Group II Phospholipases A2; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Interleukin-6; Keto Acids; Male; Middle Aged; Pyrroles; Treatment Outcome | 2011 |
Inhibition of secretory phospholipase A(2) in patients with acute coronary syndromes: rationale and design of the vascular inflammation suppression to treat acute coronary syndrome for 16 weeks (VISTA-16) trial.
Topics: Acetates; Acute Coronary Syndrome; Atorvastatin; Double-Blind Method; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Inflammation; Keto Acids; Phospholipases A2, Secretory; Pyrroles | 2012 |
Effects of the PPAR-δ agonist MBX-8025 on atherogenic dyslipidemia.
Topics: Acetates; Analysis of Variance; Atherosclerosis; Atorvastatin; Biomarkers; Chi-Square Distribution; Double-Blind Method; Drug Therapy, Combination; Dyslipidemias; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Lipoproteins; Male; Middle Aged; Obesity; Overweight; Particle Size; PPAR gamma; Pyrroles; Time Factors; Treatment Outcome; Triazoles | 2012 |
Varespladib and cardiovascular events in patients with an acute coronary syndrome: the VISTA-16 randomized clinical trial.
Topics: Acetates; Acute Coronary Syndrome; Aged; Angina, Unstable; Atherosclerosis; Atorvastatin; Double-Blind Method; Early Termination of Clinical Trials; Female; Heptanoic Acids; Humans; Indoles; Keto Acids; Male; Middle Aged; Myocardial Infarction; Phospholipases A; Phospholipases A2, Secretory; Pyrroles; Risk; Stroke; Survival Analysis; Treatment Outcome | 2014 |
131 other study(ies) available for pyrroles and phenyl acetate
| Article | Year |
|---|---|
The role of copper in preventing gastrointestinal damage by acidic anti-inflammatory drugs.
Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chelating Agents; Copper; Edema; Female; In Vitro Techniques; Indomethacin; Ketoprofen; Male; Naproxen; Niflumic Acid; Peptic Ulcer; Prostaglandins E; Pyrroles; Rats | 1976 |
Activity of tolmetin on levels of cyclic nucleotides in experimental pleurisy.
Topics: Acetates; Animals; Cyclic AMP; Cyclic GMP; Indomethacin; Male; Pleurisy; Pyrroles; Rats; Tolmetin | 1979 |
Synthesis of 2-, 4- and 5-benzoylpyrrole-3-acetic acids and study of their in vitro effects on active oxygen species.
Topics: Acetates; Chemical Phenomena; Chemistry, Physical; Dimethyl Sulfoxide; Electron Spin Resonance Spectroscopy; Formaldehyde; Free Radicals; Lipid Peroxidation; Oxygen; Pyrroles | 1990 |
Synthesis and antiinflammatory and analgesic activity of 5-aroyl-6-(methylthio)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-ca rboxyl ic acids and 1-methyl-4-(methylthio)-5-aroylpyrrole-2-acetic acids.
Topics: Acetates; Analgesia; Animals; Aspirin; Benzoquinones; Carboxylic Acids; Carrageenan; Chemical Phenomena; Chemistry; Edema; Inflammation; Mice; Molecular Structure; Pain Measurement; Phenylbutazone; Pyrroles; Quinones; Rats | 1989 |
[Anti-inflammatory 2,3-dihydro-1H-pyrrolizine. 13. Isomeric (diaryl-dihydropyrrolizinyl)acetic acids and 2-(diaryldihydropyrrolizinyl)-ethanols].
Topics: Acetates; Anti-Inflammatory Agents; Chemical Phenomena; Chemistry; Ethanol; Prostaglandins; Pyrroles; SRS-A | 1988 |
[Anti-inflammatory 2,3-dihydro-1H-pyrrolizines. 8. Synthesis and decarboxylation of 6,7-diaryl-2,3-dihydro-1H-pyrrolizin-5-yl-acetic acid (DADHP-2-acetic acid)].
Topics: Acetates; Animals; Anti-Inflammatory Agents; Chemical Phenomena; Chemistry; Decarboxylation; Hydrolysis; Oxidation-Reduction; Pyrroles; Rats | 1986 |
The pharmacology of batrachotoxin. I. Effects on the contractile mechanism and on neuromuscular transmission of mammalian skeletal muscle.
Topics: Acetates; Alkaloids; Animals; Antitoxins; Anura; Caffeine; Calcium Chloride; Cell Membrane Permeability; Diaphragm; Drug Antagonism; Drug Synergism; Electric Stimulation; In Vitro Techniques; Membrane Potentials; Microscopy, Electron; Muscle Contraction; Muscles; Neuromuscular Depolarizing Agents; Nitriles; Phrenic Nerve; Potassium Chloride; Pyrroles; Rats; Sarcoplasmic Reticulum; Sodium; Steroids; Synaptic Transmission; Temperature; Tetrodotoxin; Time Factors; Toxins, Biological; Tubocurarine | 1971 |
[A-b Isomerism of cyano-aquo-corrinoids. On the equilibrium condition of the isomerization reaction].
Topics: Acetates; Aminobutyrates; Aminocaproates; Carbon Dioxide; Carbon Monoxide; Chromatography; Chromatography, Paper; Hot Temperature; Light; Porphyrins; Pyrroles; Stereoisomerism; Vitamin B 12 | 1968 |
Simple method for determination of urinary -aminolevulinic acid as an index of lead exposure.
Topics: Acetates; Acetoacetates; Clinical Enzyme Tests; Evaluation Studies as Topic; Humans; Indicators and Reagents; Lead Poisoning; Levulinic Acids; Male; Mass Screening; Methods; Porphobilinogen; Propionates; Pyrroles; Spectrophotometry; Time Factors | 1972 |
5-Benzoyl-1-methylpyrrole-2-acetic acids as antiinflammatory agents. 2. The 4-methyl compounds.
Topics: Acetates; Animals; Anti-Inflammatory Agents; Benzoates; Carrageenan; Edema; Kaolin; Methylation; Pyrroles; Structure-Activity Relationship | 1973 |
Chemical and enzymatic polymerization of 2-aminomethyl-3,3'-carboxymethyl-4,4'-( -carboxyethyl)dipyrrylmethane.
Topics: Acetates; Aminohydrolases; Carbon Isotopes; Chemical Phenomena; Chemistry; Hot Temperature; Isomerases; Methane; Methylamines; Plants; Porphobilinogen; Propionates; Pyrroles; Stereoisomerism | 1973 |
Preparation of 14 C-labeled showdomycin.
Topics: Acetates; Anti-Bacterial Agents; Carbon Isotopes; Chemical Phenomena; Chemistry; Chromatography; Chromatography, Paper; Fermentation; Pyrroles; Ribose; Streptomyces | 1971 |
[Critical study of new contraceptive methods].
Topics: Acetates; Adult; Antibodies; Antineoplastic Agents; Busulfan; Contraceptives, Oral; Depression, Chemical; Estrogens; Female; Fertilization; Humans; Intrauterine Devices; Male; Medroxyprogesterone; Mestranol; Methods; Nitrofurans; Norethindrone; Norethynodrel; Pyrroles; Spermatozoa; Thiazoles; Triethylenemelamine | 1971 |
The reaction of N-alpha-(bromoacetoxymethyl)maleimide with hemoglobin.
Topics: Acetates; Alkylation; Amino Acid Sequence; Animals; Bromine; Carbon Monoxide; Carboxypeptidases; Chemical Phenomena; Chemistry; Chromatography, Ion Exchange; Cyanides; Cysteine; Electrophoresis; Esters; Hemoglobins; Horses; Humans; Hydrogen-Ion Concentration; Hydrolysis; Methemoglobin; Osmotic Pressure; Protein Denaturation; Pyrroles; Sulfhydryl Compounds; Valine | 1971 |
Biosynthesis of cholesterol and cholesterol acetate in dendrobatid arrow poison frogs.
Topics: Acetates; Alkaloids; Animals; Anura; Carbon Isotopes; Cholesterol; Chromatography, Thin Layer; Mevalonic Acid; Pregnanes; Pyrroles; Quinolines; Skin; Toxins, Biological | 1971 |
[Steroids and sex hormones. 241. The partial synthesis of 3-methoxy--3-, 9- -oxido-7- hydroxy-11- -acetoxy-5- steroids].
Topics: Acetates; Alkaloids; Hydroxylation; Methods; Methylation; Oxides; Pregnanes; Pyrroles; Toxins, Biological | 1971 |
5-Benzoyl-1-methylpyrrole-2-acetic acids as antiinflammatory agents.
Topics: Acetates; Animals; Anti-Inflammatory Agents; Benzoates; Carrageenan; Edema; Granuloma; Indomethacin; Kaolin; Male; Phenylbutazone; Pyrroles; Structure-Activity Relationship | 1971 |
Enzymic interconversion of -pyrroline-5-carboxylic acid and related amino acids. I. A modified method of determination of -pyrroline-5-carboxylic acid.
Topics: Acetates; Animals; Carboxylic Acids; Enzymes; Indicators and Reagents; Liver; Methods; Ornithine; Pyrroles; Rats; Spectrophotometry; Transaminases | 1971 |
Nicotinic acid metabolism. V. A cobamide coenzyme-dependent conversion of alpha-methyleneglutaric acid to dimethylmaleic acid.
Topics: Acetates; Ammonia; Aniline Compounds; Carbon Dioxide; Carbon Isotopes; Clostridium; Glutarates; Intrinsic Factor; Isomerases; Magnetic Resonance Spectroscopy; Maleates; Propionates; Pyrroles; Vitamin B 12 | 1970 |
[The reaction of N-acyl-sec-amino acids with acetic anhydride].
Topics: Acetates; Amino Acids; Anhydrides; Carbon Dioxide; Oxazoles; Pyrroles | 1970 |
Inhibition of choline acetyltransferase from bovine caudate nucleus by sulfhydryl reagents and reactivation of the inhibited enzyme.
Topics: Acetamides; Acetates; Acetylcholine; Acyltransferases; Anhydrides; Animals; Arsenic; Benzoates; Cadmium; Carbon Isotopes; Cattle; Caudate Nucleus; Chlorides; Choline; Chromatography, Ion Exchange; Coenzyme A; Cyanides; Cystamine; Enzyme Activation; Ethylmaleimide; Glutathione; Hydrogen-Ion Concentration; Iodine; Iodoacetates; Mercuribenzoates; Mercury; Nitro Compounds; Oxides; Pyridines; Pyrroles; Sulfhydryl Reagents; Sulfides; Thioglycolates; Thiosulfates | 1970 |
Regulation of arginine and proline catabolism in Bacillus licheniformis.
Topics: Acetates; Arginase; Arginine; Bacillus; Enzyme Induction; Enzyme Repression; Glucose; Glutamates; Glycerol; Oxidoreductases; Proline; Pyrroles; Pyruvates; Transaminases | 1968 |
A synthesis of 2,6-diacetyldeuterioporphyrin II dimethyl ester.
Topics: Acetates; Anhydrides; Bromides; Chemical Phenomena; Chemistry; Porphyrins; Pyrroles; Stereoisomerism | 1968 |
[On the chemistry and biochemistry of corrinoids, 28. Isolation and characterization of carboxylic acid isomers].
Topics: Acetates; Acids; Amino Alcohols; Benzimidazoles; Cerium; Chromatography, Ion Exchange; Crystallization; Pyrroles; Stereoisomerism; Vitamin B 12 | 1968 |
On the crystal structure of 5-oxo-6-N-methylformylamino-4,5-dihydro-1,2-dithiolo(4,3-b)pyrrole.
Topics: Acetates; Anti-Bacterial Agents; Chemical Phenomena; Chemistry; Crystallization; Pyrroles; X-Ray Diffraction | 1969 |
The optical activity of urobilins derived from phycoerythrobiln.
Topics: Acetates; Catalysis; Chemical Phenomena; Chemistry, Physical; Crystallization; Eukaryota; Infrared Rays; Methanol; Models, Structural; Optical Rotatory Dispersion; Oxidation-Reduction; Protein Denaturation; Pyrroles; Spectrum Analysis; Urobilin | 1967 |
In situ polymerization of pyrrole in animal tissue in the formation of hybrid biomaterials.
Topics: Acetates; Acetic Acid; Alkanesulfonic Acids; Animals; Biocompatible Materials; Chlorides; Ferric Compounds; Paraffin Embedding; Pericardium; Polymers; Pyrroles; Swine; Tissue Fixation | 1995 |
Effect of fedotozine on the cardiovascular pain reflex induced by distension of the irritated colon in the anesthetized rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetates; Acetic Acid; Amino Acid Sequence; Anesthesia; Animals; Benzyl Compounds; Blood Pressure; Colon; Dose-Response Relationship, Drug; Male; Molecular Sequence Data; Pain; Propylamines; Pyrroles; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reflex; Thiophenes | 1994 |
ML 3000 reduces gastric prostaglandin synthesis without causing mucosal injury.
Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Adhesion; Cyclooxygenase Inhibitors; Gastric Mucosa; Leukocytes; Lipoxygenase Inhibitors; Male; Prostaglandins; Pyrroles; Rabbits; Rats; Rats, Wistar; Stomach Ulcer | 1994 |
General pharmacology of [2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3- dihydro-1H-pyrrolizine-5-yl]-acetic acid in experimental animals.
Topics: Acetates; Animals; Behavior, Animal; Cats; Central Nervous System; Digestive System; Dogs; Female; Guinea Pigs; Hemodynamics; Kidney; Lipoxygenase Inhibitors; Male; Mice; Mice, Inbred ICR; Muscle Contraction; Muscle, Skeletal; Muscle, Smooth; Pyrroles; Rats; Rats, Wistar; Respiratory System | 1995 |
Distribution and excretion of [14C]-labelled [2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine-5- yl]- [2'-14C]-acetic acid in rats.
Topics: Acetates; Animals; Autoradiography; Chromatography, High Pressure Liquid; Feces; Female; Isotope Labeling; Lipoxygenase Inhibitors; Magnetic Resonance Spectroscopy; Pyrroles; Rats; Rats, Inbred Strains; Tissue Distribution | 1995 |
Studies on the in vitro and in vivo genotoxicity of [2,2-dimethyl-6- (4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl]-acetic acid.
Topics: Acetates; Animals; Bone Marrow; Bone Marrow Cells; Cells, Cultured; Chromosome Aberrations; Cricetinae; Cricetulus; DNA Repair; Female; Lipoxygenase Inhibitors; Male; Mutagenicity Tests; Mutagens; Pyrroles; Rats; Rats, Wistar; Salmonella typhimurium | 1995 |
Gastrointestinal tolerance of [2,2-dimethyl-6-(4-chlorophenyl-7-phenyl- 2,3-dihydro-1H-pyrrolizine-5-yl]-acetic acid in the rat.
Topics: Acetates; Animals; Gastric Mucosa; Indomethacin; Intestinal Mucosa; Lipoxygenase Inhibitors; Male; Peptic Ulcer; Peptic Ulcer Hemorrhage; Pyrroles; Rats; Rats, Wistar | 1994 |
Acute and chronic anti-inflammatory properties of [2,2-dimethyl-6-(4- chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl]-acetic acid.
Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Body Weight; Carrageenan; Cyclooxygenase Inhibitors; Edema; Female; Foot; Indomethacin; Male; Pyrroles; Rats; Rats, Wistar | 1995 |
(6,7-Diaryldihydropyrrolizin-5-yl)acetic acids, a novel class of potent dual inhibitors of both cyclooxygenase and 5-lipoxygenase.
Topics: Acetates; Animals; Cattle; Cyclooxygenase Inhibitors; Humans; In Vitro Techniques; Lipoxygenase Inhibitors; Pyrroles; Structure-Activity Relationship | 1994 |
Pharmacological profile of a new pyrrolizine derivative inhibiting the enzymes cyclo-oxygenase and 5-lipoxygenase.
Topics: Acetates; Animals; Arachidonic Acid; Arthritis, Experimental; Benzoquinones; Blood Coagulation; Bronchoconstriction; Carrageenan; Cyclooxygenase Inhibitors; Edema; Female; Guinea Pigs; In Vitro Techniques; Lipoxygenase Inhibitors; Male; Mice; Mice, Inbred ICR; Pain Measurement; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyrroles; Rabbits; Rats; Rats, Sprague-Dawley; Yeast, Dried | 1994 |
Effects of some ionophore antibiotics and polyoxins on the growth of anaerobic rumen fungi.
Topics: Acetates; Acetic Acid; Animals; Antifungal Agents; Bacteria; Butyrates; Butyric Acid; Chytridiomycota; Dose-Response Relationship, Drug; Eukaryota; Fatty Acids, Volatile; Ionophores; Monensin; Peptides; Propionates; Pyrans; Pyrimidine Nucleosides; Pyrroles; Rumen; Sheep | 1993 |
Pyralomicins, novel antibiotics from Microtetraspora spiralis. III. Biosynthesis of pyralomicin 1a.
Topics: Acetates; Actinomycetales; Anti-Bacterial Agents; Benzopyrans; Carbon; Chromones; Glucose; Magnetic Resonance Spectroscopy; Proline; Pyrroles | 1996 |
Oxidized low density lipoprotein stimulates protein kinase C (PKC) activity and expression of PKC-isotypes via prostaglandin-H-synthase in P388D1 cells.
Topics: Acetates; Animals; Cyclooxygenase Inhibitors; Cytosol; Enzyme Activation; Enzyme Induction; Indomethacin; Isoenzymes; Leukemia P388; Lipoproteins, LDL; Lipoxygenase Inhibitors; Macrophages; Masoprocol; Mice; Neoplasm Proteins; Nitrobenzenes; Oxidation-Reduction; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Protein Processing, Post-Translational; Pyrroles; Serum Albumin, Bovine; Sulfonamides | 1997 |
The effects of ML 3000 on antigen-induced responses in sheep.
Topics: Acetates; Aerosols; Animals; Antigens; Bronchi; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Cyclooxygenase Inhibitors; Female; Hypersensitivity, Delayed; Lipoxygenase Inhibitors; Pyrroles; Sheep | 1997 |
Kinetic resolution in palladium-catalyzed asymmetric allylic alkylations by a P,O ligand system.
Topics: Acetates; Catalysis; Chromatography, High Pressure Liquid; Cyclization; Magnetic Resonance Spectroscopy; Molecular Structure; Organometallic Compounds; Oxazoles; Palladium; Peptides; Phosphines; Proline; Pyrroles; Stereoisomerism; Structure-Activity Relationship | 2001 |
Dual inhibition of 5-lipoxygenase and cyclooxygenases 1 and 2 by ML3000 reduces joint destruction in adjuvant arthritis.
Topics: Acetates; Animals; Arachidonate 5-Lipoxygenase; Arthritis, Experimental; Arthritis, Rheumatoid; Cyclooxygenase Inhibitors; Disease Models, Animal; Female; Lipoxygenase Inhibitors; Probability; Prostaglandin-Endoperoxide Synthases; Pyrroles; Range of Motion, Articular; Rats; Rats, Inbred Lew; Reference Values; Sensitivity and Specificity; Severity of Illness Index; Statistics, Nonparametric; Treatment Outcome | 2001 |
[Double blockade should protect the stomach. New approach to rheumatism].
Topics: Acetates; Clinical Trials as Topic; Cyclooxygenase Inhibitors; Humans; Lipoxygenase Inhibitors; Osteoarthritis; Pyrroles; Stomach Ulcer | 2001 |
In vivo dual inhibition of cyclooxygenase and lipoxygenase by ML-3000 reduces the progression of experimental osteoarthritis: suppression of collagenase 1 and interleukin-1beta synthesis.
Topics: Acetates; Animals; Collagenases; Cyclooxygenase Inhibitors; Dogs; Interleukin-1; Lipoxygenase; Lipoxygenase Inhibitors; Matrix Metalloproteinase Inhibitors; Osteoarthritis; Prostaglandin-Endoperoxide Synthases; Pyrroles | 2001 |
Highly stereoselective syntheses of five- and seven-membered ring heterocycles from ylides generated by catalytic reactions of styryldiazoacetates with aldehydes and imines.
Topics: Acetates; Aldehydes; Azepines; Catalysis; Crystallography, X-Ray; Diazonium Compounds; Imines; Models, Molecular; Pyrroles; Stereoisomerism; Styrenes | 2001 |
Antithrombotic and platelet function inhibiting effects of ML3000, a new antiinflammatory drug with Cox/5-LOX inhibitory activity.
Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Fibrinolytic Agents; Lipoxygenase Inhibitors; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyrroles; Rats; Rats, Wistar | 2002 |
The mechanism of action of the new antiinflammatory compound ML3000: inhibition of 5-LOX and COX-1/2.
Topics: Acetates; Adult; Animals; Anti-Inflammatory Agents, Non-Steroidal; Colon; Cyclooxygenase Inhibitors; Edema; Gastric Mucosa; Humans; Leukotriene B4; Leukotriene C4; Lipoxygenase Inhibitors; Male; Pyrroles; Rats; Rats, Sprague-Dawley; Rats, Wistar; Stomach; Thromboxane B2 | 2002 |
Study of the role of leukotriene B()4 in abnormal function of human subchondral osteoarthritis osteoblasts: effects of cyclooxygenase and/or 5-lipoxygenase inhibition.
Topics: Acetates; Alkaline Phosphatase; Blotting, Western; Cyclooxygenase Inhibitors; Dinoprostone; Female; Humans; In Vitro Techniques; Leukotriene B4; Lipoxygenase Inhibitors; Male; Middle Aged; Nitrobenzenes; Osteoarthritis; Osteoblasts; Osteocalcin; Pyrroles; Quinolines; Sulfonamides | 2002 |
Licofelone (ML-3000), a dual inhibitor of 5-lipoxygenase and cyclooxygenase, reduces the level of cartilage chondrocyte death in vivo in experimental dog osteoarthritis: inhibition of pro-apoptotic factors.
Topics: Acetates; Administration, Oral; Animals; Apoptosis; Cartilage, Articular; Chondrocytes; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Drug Administration Schedule; Immunohistochemistry; Interleukin-1; Matrix Metalloproteinase 1; Nitric Oxide Synthase; Osteoarthritis; Probability; Pyrroles; Reference Values; Sensitivity and Specificity; Statistics, Nonparametric | 2002 |
Synthesis of [5-(4-pyrrol-1-yl-benzoyl)-1 H-pyrrol-2-yl)]-acetic acid and in vitro study of its inhibitory activity on aldose reductase enzyme and on protein glycation.
Topics: Acetates; Aldehyde Reductase; Animals; Enzyme Inhibitors; Glycation End Products, Advanced; Indicators and Reagents; Lens, Crystalline; Magnetic Resonance Spectroscopy; Proteins; Pyrroles; Rats; Rats, Inbred F344; Serum Albumin, Bovine; Spectrometry, Fluorescence; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet | 2002 |
Avasimibe and atorvastatin synergistically reduce cholesteryl ester content in THP-1 macrophages.
Topics: Acetamides; Acetates; Atorvastatin; Cells, Cultured; Cholesterol Esters; Drug Synergism; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Macrophages; Pyrroles; Sulfonamides; Sulfonic Acids | 2002 |
Licofelone, a dual lipoxygenase-cyclooxygenase inhibitor, downregulates polymorphonuclear leukocyte and platelet function.
Topics: Acetates; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Down-Regulation; Humans; Lipoxygenase; Lipoxygenase Inhibitors; Neutrophils; Platelet Aggregation Inhibitors; Platelet Function Tests; Prostaglandin-Endoperoxide Synthases; Pyrroles | 2002 |
Substituted pyrrol-1-ylacetic acids that combine aldose reductase enzyme inhibitory activity and ability to prevent the nonenzymatic irreversible modification of proteins from monosaccharides.
Topics: Acetates; Aldehyde Reductase; Animals; Diabetes Mellitus; Enzyme Inhibitors; Female; Fructose; Male; Monosaccharides; Oxidation-Reduction; Proteins; Pyrroles; Rats; Rats, Inbred F344; Serum Albumin; Structure-Activity Relationship | 2003 |
Highly selective catalyst-directed pathways to dihydropyrroles from vinyldiazoacetates and imines.
Topics: Acetates; Catalysis; Copper; Imines; Magnetic Resonance Spectroscopy; Pyrroles; Rhodium; Vinyl Compounds | 2003 |
Relative contribution of acetylated cyclo-oxygenase (COX)-2 and 5-lipooxygenase (LOX) in regulating gastric mucosal integrity and adaptation to aspirin.
Topics: Acetates; Acetylation; Adaptation, Physiological; Animals; Arachidonate 5-Lipoxygenase; Aspirin; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Gastric Mucosa; Hydroxyeicosatetraenoic Acids; Isoenzymes; Leukotriene B4; Lipoxins; Lipoxygenase Inhibitors; Models, Biological; Prostaglandin-Endoperoxide Synthases; Pyrroles; Rats | 2003 |
International Conference on Inflammopharmacology -- VIII Side-Effects of Anti-inflammatory Drugs Symposium.
Topics: Acetates; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Humans; Nitric Oxide Donors; Osteoarthritis; Pyrroles | 2003 |
Anti arthritic drugs--SMi conference: dual inhibitors. 28-29 April 2003, London, UK.
Topics: Acetates; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Arthritis; Clinical Trials as Topic; Complement Activation; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Humans; Isoenzymes; Lipoxygenase Inhibitors; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Pyrroles; Thalidomide; Tumor Necrosis Factor-alpha | 2003 |
Evidence that 5-lipoxygenase and acetylated cyclooxygenase 2-derived eicosanoids regulate leukocyte-endothelial adherence in response to aspirin.
Topics: Acetates; Acetylation; Adhesiveness; Arachidonate 5-Lipoxygenase; Aspirin; CD11a Antigen; Cells, Cultured; Cyclooxygenase 2; Dose-Response Relationship, Drug; E-Selectin; Eicosanoids; Endothelial Cells; Endothelium, Vascular; Fatty Alcohols; Glycols; Humans; Isoenzymes; Leukocytes; Leukotriene B4; Lipopolysaccharides; Lipoxins; Lipoxygenase; Membrane Proteins; Neutrophils; Prostaglandin-Endoperoxide Synthases; Prostaglandins E; Pyrans; Pyrroles; Quinolines; Quinolones; Umbilical Cord; Up-Regulation | 2003 |
PRESENT STATUS OF THE EHRLICH ALDEHYDE REACTION FOR URINARY PORPHOBILINOGEN.
Topics: Acetates; Alcohols; Aldehydes; Chloroform; Chromatography; Humans; Hydrochloric Acid; Indicators and Reagents; Porphobilinogen; Porphyrias; Porphyrins; Pyrroles; Urine | 1964 |
DETERMINATION OF GLUCOSAMINE AND GALACTOSAMINE USING BORATE BUFFERS FOR MODIFICATION OF THE ELSON-MORGAN AND MORGAN-ELSON REACTIONS.
Topics: Acetates; Borates; Buffers; Colorimetry; Galactosamine; Glucosamine; Glycosaminoglycans; Hexosamines; Indicators and Reagents; Pyrroles; Research | 1964 |
FURTHER OBSERVATIONS ON IN VITRO RADIOSENSITIZATION OF RABBIT ERYTHROCYTES BY IODOACETIC ACID AND RELATED SUBSTANCES.
Topics: Acetates; Adenosine Triphosphate; Amides; Anesthetics, Local; Animals; Erythrocytes; Ethylmaleimide; Fluorides; Hemolysis; In Vitro Techniques; Iodides; Iodine; Iodoacetates; Iodoacetic Acid; Lactates; Nitrogen; Oxygen; Pharmacology; Potassium; Propionates; Pyrroles; Rabbits; Radiation Effects; Radiation-Sensitizing Agents; Research | 1964 |
Methyl (+/-)-1-ethyl-2-hydroxy-4-(4-methoxybenzoyl)-5-(4-methoxyphenyl)-3-oxo-2,3-dihydro-1H-pyrrole-2-acetate.
Topics: Acetates; Anti-Infective Agents; Crystallography, X-Ray; Hydrogen Bonding; Molecular Structure; Pyrroles | 2003 |
Treatment with licofelone prevents abnormal subchondral bone cell metabolism in experimental dog osteoarthritis.
Topics: Acetates; Animals; Antirheumatic Agents; Arthritis, Experimental; Cells, Cultured; Cyclooxygenase Inhibitors; Dinoprostone; Dogs; Enzyme Inhibitors; Insulin-Like Growth Factor I; Leukotriene B4; Lipoxygenase Inhibitors; Osteoarthritis; Osteoblasts; Pyrroles; Urokinase-Type Plasminogen Activator | 2004 |
The inhibition of subchondral bone resorption in the early phase of experimental dog osteoarthritis by licofelone is associated with a reduction in the synthesis of MMP-13 and cathepsin K.
Topics: Acetates; Animals; Bone Resorption; Cathepsin K; Cathepsins; Collagenases; Dogs; Matrix Metalloproteinase 13; Matrix Metalloproteinase Inhibitors; Osteoarthritis; Pyrroles | 2004 |
Inhibition of gastric H,K-ATPase activity and gastric epithelial cell IL-8 secretion by the pyrrolizine derivative ML 3000.
Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line, Tumor; Enzyme Inhibitors; Gastric Mucosa; Humans; Hydrochloric Acid; Interleukin-1; Interleukin-8; Omeprazole; Parietal Cells, Gastric; Proton Pump Inhibitors; Pyrroles; Rabbits | 2004 |
Licofelone, an inhibitor of cyclooxygenase and 5-lipoxygenase, specifically inhibits cyclooxygenase-1-dependent platelet activation.
Topics: Acetates; Arachidonic Acid; Aspirin; Blood Platelets; Collagen; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Epinephrine; Humans; In Vitro Techniques; Isoenzymes; Lipoxygenase Inhibitors; Membrane Proteins; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Pyrroles; Quinolines; Thrombin; Thromboxane B2 | 2004 |
A novel one-pot, four component synthesis of some densely functionalized pyrroles.
Topics: Acetates; Acetylene; Carboxylic Acids; Molecular Structure; Ninhydrin; Organophosphorus Compounds; Phosphoranes; Pyrroles; Thiocyanates | 2003 |
Synthetic approaches to indolo[6,7-a]pyrrolo[3,4-c]carbazoles: potent cyclin D1/CDK4 inhibitors.
Topics: Acetamides; Acetates; Antineoplastic Agents; Carbazoles; Cyclin D1; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinases; Enzyme Inhibitors; Humans; Indoles; Maleimides; Oxidants; Photochemistry; Proto-Oncogene Proteins; Pyrroles; Structure-Activity Relationship | 2004 |
[1-(3,5-difluoro-4-hydroxyphenyl)-1H-pyrrol-3-yl]phenylmethanone as a bioisostere of a carboxylic acid aldose reductase inhibitor.
Topics: Acetates; Aldehyde Reductase; Animals; Fructose; Phenols; Pyrroles; Rats; Serum Albumin, Bovine | 2004 |
The regulation of human MMP-13 by licofelone, an inhibitor of cyclo-oxygenases and 5-lipoxygenase, in human osteoarthritic chondrocytes is mediated by the inhibition of the p38 MAP kinase signalling pathway.
Topics: Acetates; Aged; Cells, Cultured; Chondrocytes; Collagenases; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Humans; Interleukin-1; Lipoxygenase Inhibitors; MAP Kinase Signaling System; Matrix Metalloproteinase 13; Middle Aged; Osteoarthritis, Knee; Promoter Regions, Genetic; Pyrroles; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription, Genetic | 2005 |
Leukotriene and prostaglandin synthesis pathways in osteoarthritic synovial membranes: regulating factors for interleukin 1beta synthesis.
Topics: Acetates; Aged; Arachidonic Acid; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Drug Combinations; Female; Humans; In Vitro Techniques; Leukotriene B4; Lipopolysaccharides; Male; Masoprocol; Naproxen; Osteoarthritis, Knee; Pyrroles; Signal Transduction; Synovial Membrane | 2005 |
Effect of licofelone against NSAIDs-induced gastrointestinal ulceration and inflammation.
Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Female; Humans; Indomethacin; Inflammation; Leukotriene B4; Lipid Peroxidation; Male; Mesentery; Mice; Neutrophils; Pyrroles; Rats; Stomach Ulcer; Time Factors | 2005 |
Dual inhibition of cyclo-oxygenases and 5-lipoxygenase: a novel therapeutic approach to inflammation?
Topics: Acetates; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Humans; Inflammation; Lipoxygenase Inhibitors; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Pyrroles | 2005 |
1,5-Diarylpyrrole-3-acetic acids and esters as novel classes of potent and highly selective cyclooxygenase-2 inhibitors.
Topics: Acetates; Animals; Binding Sites; Cell Line; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Esters; Membrane Proteins; Mice; Models, Molecular; Prostaglandin-Endoperoxide Synthases; Pyrroles | 2005 |
Licofelone, a novel 5-LOX/COX-inhibitor, attenuates leukocyte rolling and adhesion on endothelium under flow.
Topics: Acetates; Cell Adhesion; Cell Adhesion Molecules; Cell Movement; Cells, Cultured; Cyclooxygenase Inhibitors; Endothelial Cells; Humans; Leukocytes; Lipoxygenase Inhibitors; Pyrroles; RNA, Messenger | 2005 |
The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanases.
Topics: Acetates; ADAM Proteins; ADAMTS4 Protein; Animals; Anterior Cruciate Ligament; Arachidonate 5-Lipoxygenase; Cathepsin K; Cathepsins; Collagenases; Cyclooxygenase Inhibitors; Dogs; Down-Regulation; Drug Evaluation; Enzyme Induction; Gene Expression Profiling; Gene Expression Regulation; Lipoxygenase Inhibitors; Matrix Metalloproteinase 13; Osteoarthritis; Procollagen N-Endopeptidase; Pyrroles; RNA, Messenger | 2005 |
Anti-inflammatory effect of licofelone against various inflammatory challenges.
Topics: Acetates; Animals; Anti-Inflammatory Agents; Carrageenan; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Edema; Female; Freund's Adjuvant; Granuloma; Hyperalgesia; Indomethacin; Lipoxygenase Inhibitors; Mice; Pain Measurement; Pain Threshold; Pyrroles; Rats; Rats, Wistar; Time Factors; Touch | 2006 |
Enantioselective 1,3-dipolar cycloaddition reaction between diazoacetates and alpha-substituted acroleins: total synthesis of manzacidin A.
Topics: Acetates; Acrolein; Alkaloids; Animals; Cyclization; Diazonium Compounds; Naphthols; Porifera; Pyrimidines; Pyrroles; Stereoisomerism; Titanium | 2006 |
Licofelone reduces progression of structural changes in a canine model of osteoarthritis under curative conditions: effect on protease expression and activity.
Topics: Acetates; Animals; Anterior Cruciate Ligament; Cartilage, Articular; Collagenases; Disease Models, Animal; Disease Progression; Dogs; Enzyme Inhibitors; Metalloproteases; Osteoarthritis, Knee; Pyrroles; Stifle | 2006 |
The lipoxygenase-cyclooxygenase inhibitor licofelone prevents thromboxane A2-mediated cardiovascular derangement triggered by the inflammatory peptide fMLP in the rabbit.
Topics: Acetates; Animals; Aspirin; Blood Pressure; Cyclooxygenase Inhibitors; Disease Models, Animal; Electrocardiography; Heart Rate; Inflammation; Lactones; Leukotriene B4; Lipoxygenase Inhibitors; Male; Myocardial Ischemia; N-Formylmethionine Leucyl-Phenylalanine; Pyrroles; Rabbits; Sulfones; Thromboxane A2; Time Factors | 2006 |
BF2 complex of fluorinated dipyrrolyldiketone: a new class of efficient receptor for acetate anions.
Topics: Acetates; Boron Compounds; Circular Dichroism; Fluorides; Ketones; Kinetics; Models, Molecular; Pyrroles; Quantum Theory; Spectrometry, Fluorescence; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet | 2006 |
Licofelone, a balanced inhibitor of cyclooxygenase and 5-lipoxygenase, reduces inflammation in a rabbit model of atherosclerosis.
Topics: Acetates; Animals; Atherosclerosis; Chemokine CCL2; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Leukotriene B4; Lipids; Lipoxygenase Inhibitors; Macrophages; Male; NF-kappa B; Pyrroles; Rabbits; RNA, Messenger; Thromboxane B2; Tunica Intima | 2007 |
Effects on primary haemostasis of an anti-inflammatory agent with 5-lipoxygenase and cyclooxygenase inhibitory activity.
Topics: Acetates; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Aspirin; Blood Platelets; Collagen; Cyclooxygenase Inhibitors; Endothelium, Vascular; Enzyme Inhibitors; Hemostasis; Humans; Lipoxygenase Inhibitors; Platelet Aggregation; Pyrroles; Rabbits | 2006 |
Arthritis clinical trial results revealed.
Topics: Acetates; Antirheumatic Agents; Arthritis, Rheumatoid; Chondroitin Sulfates; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Osteoarthritis; Piperidines; Pyrimidines; Pyrroles | 2007 |
Controlled amine functionalization on conducting polypyrrole nanotubes as effective transducers for volatile acetic acid.
Topics: Acetates; Acetic Acid; Amines; Electrodes; Equipment Design; Fatty Acids; Glass; Macromolecular Substances; Microscopy, Electron, Transmission; Nanotubes; Polyamines; Polymers; Pyrroles; Sensitivity and Specificity; Spectrum Analysis, Raman | 2007 |
Effect of the pyrrolopyrimidine lipid peroxidation inhibitor U-101033E on neuronal and astrocytic metabolism and infarct volume in rats with transient middle cerebral artery occlusion.
Topics: Acetates; Animals; Astrocytes; Cerebral Infarction; Disease Models, Animal; Glucose; Glycolysis; Lipid Peroxidation; Magnetic Resonance Imaging; Male; Middle Cerebral Artery; Nerve Tissue Proteins; Neurons; Pyrimidines; Pyrroles; Pyrrolidines; Rats; Rats, Wistar | 2007 |
Modulating the reactivity of alpha-isocyanoacetates: multicomponent synthesis of 5-methoxyoxazoles and furopyrrolones.
Topics: Acetates; Oxazoles; Pyrroles | 2007 |
Enantioselective 1,3-dipolar cycloadditions of diazoacetates with electron-deficient olefins.
Topics: Acetates; Alkenes; Azo Compounds; Cyclization; Electrons; Imides; Molecular Structure; Pyrimidines; Pyrroles; Stereoisomerism | 2007 |
A new titanium biofunctionalized interface based on poly(pyrrole-3-acetic acid) coating: proliferation of osteoblast-like cells and future perspectives.
Topics: Acetates; Alkaline Phosphatase; Animals; Base Sequence; Cell Adhesion; Cell Proliferation; Cells, Cultured; Coated Materials, Biocompatible; Collagen Type I; DNA Primers; Materials Testing; Mice; Osteoblasts; Osteocalcin; Polymers; Pyrroles; RNA, Messenger; Spectrum Analysis; Titanium; X-Rays | 2007 |
The dual inhibitor of lipoxygenase and cyclooxygenase ML3000 decreases the expression of CXCR3 ligands.
Topics: Acetates; Arthritis, Rheumatoid; Cells, Cultured; Chemokines, CXC; Cyclooxygenase Inhibitors; Down-Regulation; Fibroblasts; Humans; Ligands; Lipoxygenase Inhibitors; Polymerase Chain Reaction; Pyrroles; Receptors, CXCR3; RNA, Messenger; Synovial Membrane | 2008 |
The molecular mechanism of the inhibition by licofelone of the biosynthesis of 5-lipoxygenase products.
Topics: 5-Lipoxygenase-Activating Proteins; Acetates; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Arsenites; Bridged Bicyclo Compounds; Calcimycin; Calcium; Carrier Proteins; Cell-Free System; Cells, Cultured; Dithiothreitol; Dose-Response Relationship, Drug; HeLa Cells; Humans; Indoles; Leukotriene Antagonists; Leukotrienes; Lipoxygenase Inhibitors; Membrane Proteins; Molecular Structure; Neutrophils; Nuclear Envelope; Pyrroles; Quinolines; Sodium Compounds; Transfection | 2007 |
A new pyrrole alkaloid isolated from Arum palaestinum Boiss. and its biological activities.
Topics: Acetates; Alkaloids; Antineoplastic Agents, Phytogenic; Arum; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Free Radical Scavengers; Humans; Magnetic Resonance Spectroscopy; Molecular Structure; Plant Extracts; Pyrroles | 2007 |
Cyclooxygenase-2 inhibitors. 1,5-diarylpyrrol-3-acetic esters with enhanced inhibitory activity toward cyclooxygenase-2 and improved cyclooxygenase-2/cyclooxygenase-1 selectivity.
Topics: Acetates; Adult; Animals; Carrageenan; Cell Line; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Edema; Female; Humans; Male; Mice; Models, Molecular; Pain Measurement; Pyrroles; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Rats, Wistar; Structure-Activity Relationship; T-Box Domain Proteins | 2007 |
Licofelone, a dual COX/5-LOX inhibitor, induces apoptosis in HCA-7 colon cancer cells through the mitochondrial pathway independently from its ability to affect the arachidonic acid cascade.
Topics: Acetates; Apoptosis; Arachidonic Acid; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Cyclooxygenase Inhibitors; Cytosol; Gene Expression Regulation, Neoplastic; Humans; Lipoxygenase Inhibitors; Membrane Potential, Mitochondrial; Mitochondria; Prostaglandin-Endoperoxide Synthases; Pyrroles | 2008 |
In vitro metabolism of 2-[6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl] acetic acid (licofelone, ML3000), an inhibitor of cyclooxygenase-1 and -2 and 5-lipoxygenase.
Topics: Acetates; Animals; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Cyclopropanes; Cytochrome P-450 Enzyme System; Glucuronosyltransferase; Hepatocytes; Humans; Lipoxygenase Inhibitors; Macaca fascicularis; Mice; Mice, Inbred Strains; Microsomes; Paclitaxel; Pyrroles; Quinolines; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Sulfides | 2008 |
Statin therapy alone and in combination with an acyl-CoA:cholesterol O-acyltransferase inhibitor on experimental atherosclerosis.
Topics: Acetamides; Acetates; Animals; Aorta, Abdominal; Aortic Diseases; Atherosclerosis; Atorvastatin; Catheterization; Cholesterol; Disease Progression; Drug Evaluation, Preclinical; Drug Synergism; Drug Therapy, Combination; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Magnetic Resonance Imaging; Matrix Metalloproteinase 1; Matrix Metalloproteinase 3; Pyrroles; Rabbits; Random Allocation; Sterol O-Acyltransferase; Sulfonamides; Sulfonic Acids | 2007 |
A rapid and sensitive LC-MS/MS assay to quantify yonkenafil in rat plasma with application to preclinical pharmacokinetics studies.
Topics: Acetates; Administration, Oral; Administration, Sublingual; Animals; Biological Availability; Buffers; Chromatography, Liquid; Cyclic Nucleotide Phosphodiesterases, Type 5; Drug Evaluation, Preclinical; Drug Stability; Fasting; Hydrogen-Ion Concentration; Injections, Intravenous; Male; Methanol; Molecular Structure; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Pyrimidinones; Pyrroles; Quality Control; Random Allocation; Rats; Rats, Wistar; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Time Factors | 2008 |
Photooxygenation of 5-dialkylamino-4-pyrrolin-3-ones. Synthesis of highly functionalized ureas, 2-oxazolidinones, and 2-oxazolinones.
Topics: Acetates; Alkanes; Alkynes; Amidines; Amines; Catalysis; Cyclization; Heterocyclic Compounds; Heterocyclic Compounds, 1-Ring; Hydrogenation; Methanol; Models, Chemical; Oxazoles; Oxazolidinones; Oxygen; Photochemistry; Pyrroles; Solvents; Urea | 2008 |
Anti-atherogenic effects of montelukast associated with reduced MCP-1 expression in a rabbit carotid balloon injury model.
Topics: Acetates; Animals; Atherosclerosis; Atorvastatin; Carotid Arteries; Catheterization; Chemokine CCL2; Cyclopropanes; Diet, Atherogenic; Disease Progression; Heptanoic Acids; Immunohistochemistry; Leukotriene Antagonists; Lipids; Male; Pyrroles; Quinolines; Rabbits; Random Allocation; Sulfides | 2009 |
Mild and efficient DBU-catalyzed amidation of cyanoacetates.
Topics: Acetates; Amides; Bridged Bicyclo Compounds, Heterocyclic; Catalysis; Combinatorial Chemistry Techniques; Immunosuppressive Agents; Molecular Structure; Piperazines; Pyrimidines; Pyrroles | 2009 |
CE-ESI-MS analysis of singly charged inorganic and organic anions using a dicationic reagent as a complexing agent.
Topics: Acetates; Anions; Benzenesulfonates; Caprylates; Electrophoresis, Capillary; Fluorocarbons; Imides; Indicators and Reagents; Mesylates; Pyrroles; Quaternary Ammonium Compounds; Spectrometry, Mass, Electrospray Ionization; Water Pollutants, Chemical; Water Supply | 2009 |
HPLC-based lipophilicity of pyrrolyl-acetic acid ARIs: Relationships with biological activity.
Topics: 1-Octanol; Acetates; Aldehyde Reductase; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kinetics; Logistic Models; Methanol; Pyrroles; Water | 2010 |
Montelukast inhibits matrix metalloproteinases expression in atherosclerotic rabbits.
Topics: Acetates; Animals; Atherosclerosis; Atorvastatin; Cyclopropanes; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leukotriene Antagonists; Lipids; Macrophages; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Myocytes, Smooth Muscle; Pyrroles; Quinolines; Rabbits; Random Allocation; Reverse Transcriptase Polymerase Chain Reaction; Sulfides | 2009 |
One-pot highly efficient synthesis of substituted pyrroles and N-bridgehead pyrroles by zinc-catalyzed multicomponent reaction.
Topics: Acetates; Amination; Amines; Catalysis; Chlorides; Nitrogen; Pyrroles; Silanes; Stereoisomerism; Substrate Specificity; Zinc Compounds | 2010 |
Design of a versatile multicomponent reaction leading to 2-amino-5-ketoaryl pyrroles.
Topics: Acetates; Aldehydes; Drug Design; Nitriles; Pyrroles; Sulfonamides | 2010 |
One-pot AgOAc-mediated synthesis of polysubstituted pyrroles from primary amines and aldehydes: application to the total synthesis of purpurone.
Topics: Acetates; Aldehydes; Amines; Dimerization; Heterocyclic Compounds, 4 or More Rings; Molecular Structure; Pyrroles; Silver Compounds | 2010 |
Formation of γ-oxoacids and 1H-pyrrol-2(5H)-ones from α,β-unsaturated ketones and ethyl nitroacetate.
Topics: Acetates; Acids; Ketones; Models, Molecular; Molecular Conformation; Nitro Compounds; Oxygen; Pyrroles | 2010 |
Development of a new class of benzoylpyrrole-based PPARα/γ activators.
Topics: Acetates; Animals; Carboxylic Acids; Hyperglycemia; Hypoglycemic Agents; Male; Mice; Mice, Obese; Obesity; PPAR alpha; PPAR gamma; Pyrroles; Rats; Structure-Activity Relationship | 2011 |
Thienopyrrole acetic acids as antagonists of the CRTH2 receptor.
Topics: Acetates; Animals; Biological Availability; Mice; Microsomes, Liver; Pyrroles; Rats; Receptors, Immunologic; Receptors, Prostaglandin | 2011 |
Cysteine cyclic pyrrole-imidazole polyamide for sequence-specific recognition in the DNA minor groove.
Topics: Acetates; Base Sequence; Cyclization; Cysteine; DNA; Imidazoles; Models, Molecular; Molecular Sequence Data; Molecular Structure; Nylons; Pyrroles | 2011 |
Novel analgesic/anti-inflammatory agents: diarylpyrrole acetic esters endowed with nitric oxide releasing properties.
Topics: Acetates; Animals; Cell Line; Constriction, Pathologic; Cyclooxygenase 2 Inhibitors; Edema; Esters; Humans; Hyperalgesia; In Vitro Techniques; Isoenzymes; Macrophages; Male; Mice; Models, Molecular; Nitric Oxide Donors; Pyrroles; Rats; Rats, Sprague-Dawley; Rats, Wistar; Structure-Activity Relationship; Vasodilator Agents | 2011 |
An efficient route to tetrahydroindeno[2,1-b]pyrroles via a base-promoted reaction of (E)-2-alkynylphenylchalcone with 2-isocyanoacetate.
Topics: Acetates; Air; Alkynes; Catalysis; Chalcones; Combinatorial Chemistry Techniques; Heterocyclic Compounds, 3-Ring; Indenes; Molecular Structure; Nitriles; Pyrroles | 2011 |
Phosphine-mediated cascade reaction of azides with MBH-acetates of acetylenic aldehydes to substituted pyrroles: a facile access to N-fused pyrrolo-heterocycles.
Topics: Acetates; Aldehydes; Alkynes; Azides; Catalysis; Cyclization; Indoles; Indolizines; Isoquinolines; Molecular Structure; Oxidation-Reduction; Phosphines; Pyrroles; Stereoisomerism; Temperature | 2012 |
Reactions of β-alkoxyvinyl polyfluoroalkyl ketones with ethyl isocyanoacetate and its use for the synthesis of new polyfluoroalkyl pyrroles and pyrrolidines.
Topics: Acetates; Catalysis; Hydrogenation; Ketones; Models, Molecular; Pyrroles; Pyrrolidines; Stereoisomerism | 2012 |
Complementary asymmetric routes to (R)-2-(7-hydroxy-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate.
Topics: Acetates; Catalysis; Fingolimod Hydrochloride; Indoles; Molecular Structure; Propylene Glycols; Pyrroles; Receptors, Lysosphingolipid; Sphingosine; Stereoisomerism | 2012 |
Functionalized heterocyclic scaffolds derived from Morita-Baylis-Hillman Acetates.
Topics: Acetates; Heterocyclic Compounds; Indolizines; Oxazocines; Pyrazoles; Pyridines; Pyrroles | 2013 |
An efficient synthesis of polysubstituted pyrroles via copper-catalyzed coupling of oxime acetates with dialkyl acetylenedicarboxylates under aerobic conditions.
Topics: Acetates; Acetylene; Carboxylic Acids; Catalysis; Copper; Isoquinolines; Oximes; Pyrroles | 2013 |
Synthesis of multi-substituted pyrroles using enamides and alkynes catalyzed by Pd(OAc)2 with molecular oxygen as an oxidant.
Topics: Acetates; Alkynes; Amides; Catalysis; Cyclization; Oxidants; Oxygen; Palladium; Pyrroles | 2014 |
Synthesis of functionalized 2-vinyl-2,3-dihydropyrroles and 3-methylene-1,2,3,4-tetrahydropyridines by palladium-catalyzed cyclization of β-enaminocarbonyl compounds with allylic bisacetates.
Topics: Acetates; Alkenes; Catalysis; Chemistry Techniques, Synthetic; Cyclization; Palladium; Pyridines; Pyrroles | 2014 |
Divergent synthesis of 2,3-dihydro-1H-pyrroles, 3-alkyl-1H-pyrroles and 3-alkenyl-1H-pyrroles from 2,4-pentadienenitriles and isocyanides.
Topics: Acetates; Alkenes; Cyanides; Electrons; Molecular Conformation; Nitriles; Pyrroles | 2014 |
IGF1R tyrosine kinase inhibitor enhances the cytotoxic effect of methyl jasmonate in endometrial cancer.
Topics: Acetates; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cyclopentanes; Dose-Response Relationship, Drug; Endometrial Neoplasms; Extracellular Signal-Regulated MAP Kinases; Female; Humans; Oxylipins; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrimidines; Pyrroles; Receptor, IGF Type 1; Time Factors | 2014 |
Design, synthesis and anti-mycobacterial activity of 1,2,3,5-tetrasubstituted pyrrolyl-N-acetic acid derivatives.
Topics: Acetates; Anti-Bacterial Agents; Dose-Response Relationship, Drug; Drug Design; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Pyrroles; Structure-Activity Relationship | 2014 |
Catalytic enantioselective addition of isocyanoacetate to 3-methyl-4-nitro-5-styrylisoxazoles under phase transfer catalysis conditions.
Topics: Acetates; Catalysis; Cyclization; Isoxazoles; Methylation; Nitriles; Nitro Compounds; Pyrroles; Pyrrolidines; Stereoisomerism | 2015 |
1-Acetyl-5-phenyl-1H-pyrrol-3-ylacetate: An aldose reductase inhibitor for the treatment of diabetic nephropathy.
Topics: Acetates; Aldehyde Reductase; Animals; Apoptosis; Cell Proliferation; Cell Survival; Cells, Cultured; Diabetic Nephropathies; Dose-Response Relationship, Drug; Enzyme Inhibitors; Molecular Structure; Pyrroles; Rats; Streptozocin; Structure-Activity Relationship | 2017 |
Quinonoid compounds via reactions of lawsone and 2-aminonaphthoquinone with α-bromonitroalkenes and nitroallylic acetates: Structural diversity by C-ring modification and cytotoxic evaluation against cancer cells.
Topics: Acetates; Alkenes; Amination; Antineoplastic Agents; Cell Line, Tumor; Chemistry Techniques, Synthetic; Furans; Halogenation; Humans; Models, Molecular; Naphthoquinones; Neoplasms; Pyrroles; Quinones; Structure-Activity Relationship | 2018 |
Antimicrobial potential of haloalkaliphilic Nocardiopsis sp. AJ1 isolated from solar salterns in India.
Topics: Acetates; Anti-Infective Agents; Bacteria; Bacterial Proteins; Dactinomycin; Fungi; Microbial Sensitivity Tests; Models, Molecular; Nocardia; Peptide Synthases; Phylogeny; Pyrazines; Pyrroles; RNA, Ribosomal, 16S; Salinity; Soil Microbiology; Viruses | 2019 |
Potential synergistic effects of novel hematopoietic prostaglandin D synthase inhibitor TAS-205 and different types of anti-allergic medicine on nasal obstruction in a Guinea pig model of experimental allergic rhinitis.
Topics: Acetates; Animals; Anti-Allergic Agents; Cell Line; Cyclopropanes; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Enzyme Inhibitors; Guinea Pigs; Humans; Intramolecular Oxidoreductases; Lipocalins; Male; Morpholines; Nasal Mucosa; Nasal Obstruction; Ovalbumin; Piperidines; Prostaglandin D2; Pyrroles; Quality of Life; Quinolines; Rats; Rhinitis, Allergic; Sulfides; Terfenadine | 2020 |
Identification of a Novel Pyrrole Alkaloid from the Edible Mushroom
Topics: Acetates; Aldehydes; Alkaloids; Basidiomycota; Complex Mixtures; Copper; Dietary Supplements; Free Radical Scavengers; Iron; Magnetic Resonance Spectroscopy; Mass Spectrometry; Pyrroles; Solvents | 2020 |
Electrochemical sensor based on MIP for highly sensitive detection of 5-hydroxyindole-3-acetic acid carcinoid cancer biomarker in human biological fluids.
Topics: Acetates; Biomarkers, Tumor; Carcinoid Tumor; Electrochemical Techniques; Electrodes; Humans; Hydroxyindoleacetic Acid; Indoles; Limit of Detection; Molecular Imprinting; Polymers; Pyrroles | 2021 |
Synthesis of 5-Fluoro-dihydroindolizines from Pyrrole-2-acetic Acids and Trifluoromethyl Alkenes via Dual C-F Bond Cleavage in a CF
Topics: Acetates; Alkenes; Hydrocarbons, Fluorinated; Indoles; Pyrroles | 2022 |
Modification of Pyrrolo[2,1-
Topics: Acetates; Chlorides; Dimethyl Sulfoxide; Isoquinolines; Pyrroles | 2022 |