pyrroles has been researched along with pha 767491 in 16 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (12.50) | 29.6817 |
| 2010's | 13 (81.25) | 24.3611 |
| 2020's | 1 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Albanese, C; Alzani, R; Avanzi, N; Ballinari, D; Bensimon, A; Brotherton, D; Cattoni, M; Ciavolella, A; Croci, V; Fiorentini, F; Healy, S; Isacchi, A; Marchesi, V; Menichincheri, M; Molinari, A; Moll, J; Montagnoli, A; Patton, V; Pesenti, E; Rainoldi, S; Santocanale, C; Sola, F; Tenca, P; Tibolla, M; Valsasina, B; Vanotti, E; Volpi, D | 1 |
| Jackson, PK | 1 |
| Catherwood, MA; Kliszczak, AE; Montagnoli, A; Murillo, LS; Natoni, A; O'Dwyer, M; Samali, A; Santocanale, C | 1 |
| Bird, TD; Guthrie, CR; Kraemer, BC; Leverenz, JB; Liachko, NF; McMillan, PJ | 1 |
| Harhen, B; Murphy, PV; Rainey, MD; Santocanale, C; Wang, GN | 1 |
| Blow, JJ; Chadha, GS; Gillespie, PJ; Kaldis, P; Poh, WT | 1 |
| Bonte, D; Melcher, K; Sasi, NK; Soon, FF; Tiwari, K; Wang, T; Weinreich, M; Xu, HE | 1 |
| Chen, X; Li, W; Shang, SQ; Shen, HQ; Zhao, XL | 1 |
| Huggett, MT; Keane, MG; Loddo, M; Pereira, SP; Proctor, I; Stoeber, K; Tudzarova, S; Williams, GH | 1 |
| He, S; Hou, J; Huang, Q; Tan, G; Xu, F; Yan, J; Yu, X; Zhang, X; Zhang, Z; Zheng, C | 1 |
| Gaboriau, D; Quachthithu, H; Rainey, MD; Santocanale, C | 1 |
| Fennell, M; Garippa, R; Liu, HY; Tuckett, AZ; Zakrzewski, JL | 1 |
| Coquel, F; Lin, YL; MacKeigan, JP; Pasero, P; Sasi, NK; Weinreich, M | 1 |
| Acharya, P; Hiebert, SW; Liu, Q; Sampathi, S; Savona, MR; Stengel, KR; Wang, J; Zhao, Y | 1 |
| Buonavoglia, C; Camero, M; Lanave, G; Lucente, MS; Martella, V; Siciliano, P; Tempesta, M; Trerotoli, P; Zizzadoro, C | 1 |
| Chang, YC; Chen, SL; Chung, YH; Hsieh-Li, HM; Huang, HJ; Huang, HY; Lee, GC; Lee-Chen, GJ; Lin, CW; Sun, YC | 1 |
16 other study(ies) available for pyrroles and pha 767491
| Article | Year |
|---|---|
A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity.
Topics: Animals; Antineoplastic Agents; Cell Cycle; Cell Cycle Proteins; Cell Death; Cell Line, Tumor; Cell Proliferation; DNA; DNA Replication; Dose-Response Relationship, Drug; Fibroblasts; HeLa Cells; Humans; Mice; Mice, Nude; Mice, SCID; Minichromosome Maintenance Complex Component 2; Molecular Structure; Nuclear Proteins; Phosphorylation; Piperidones; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrroles; Rats; Small Molecule Libraries; Structure-Activity Relationship; Xenograft Model Antitumor Assays | 2008 |
Stopping replication, at the beginning.
Topics: Animals; Antineoplastic Agents; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; DNA; DNA Replication; Humans; Minichromosome Maintenance Complex Component 2; Nuclear Proteins; Phosphorylation; Piperidones; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrroles; Xenograft Model Antitumor Assays | 2008 |
Mechanisms of action of a dual Cdc7/Cdk9 kinase inhibitor against quiescent and proliferating CLL cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Caspases; CD40 Ligand; Cell Cycle; Cell Cycle Proteins; Cells, Cultured; Cyclin-Dependent Kinase 9; DNA Replication; Gene Expression Regulation, Leukemic; Humans; Interleukin-4; Leukemia, Lymphocytic, Chronic, B-Cell; Mice; Myeloid Cell Leukemia Sequence 1 Protein; NIH 3T3 Cells; Phosphorylation; Piperidones; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-bcl-2; Pyrroles; RNA Polymerase II; Signal Transduction | 2011 |
CDC7 inhibition blocks pathological TDP-43 phosphorylation and neurodegeneration.
Topics: Animals; Animals, Genetically Modified; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Cell Cycle Proteins; Cell Line, Transformed; Disease Models, Animal; DNA-Binding Proteins; Enzyme Inhibitors; Frontal Lobe; Gene Expression Regulation; Humans; Movement; Mutation; Neurodegenerative Diseases; Phosphorylation; Piperidones; Protein Serine-Threonine Kinases; Pyrroles; RNA, Small Interfering; Serine; TDP-43 Proteinopathies; Transfection | 2013 |
Cdc7-dependent and -independent phosphorylation of Claspin in the induction of the DNA replication checkpoint.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Cell Cycle Proteins; Checkpoint Kinase 1; Chromatography, High Pressure Liquid; DNA Replication; HEK293 Cells; HeLa Cells; Humans; Hydroxyurea; Mass Spectrometry; Minichromosome Maintenance Complex Component 2; Molecular Sequence Data; Phosphopeptides; Phosphorylation; Piperidones; Protein Interaction Maps; Protein Kinases; Protein Serine-Threonine Kinases; Pyrroles; RNA Interference; RNA, Small Interfering; Substrate Specificity | 2013 |
Xenopus Cdc7 executes its essential function early in S phase and is counteracted by checkpoint-regulated protein phosphatase 1.
Topics: Animals; Cell Cycle Proteins; CHO Cells; Chromatin; Cricetinae; Cricetulus; DNA Replication; Enzyme Inhibitors; Etoposide; Ovum; Phosphorylation; Piperidones; Protein Phosphatase 1; Protein Serine-Threonine Kinases; Pyrroles; S Phase Cell Cycle Checkpoints; Xenopus; Xenopus Proteins | 2014 |
The potent Cdc7-Dbf4 (DDK) kinase inhibitor XL413 has limited activity in many cancer cell lines and discovery of potential new DDK inhibitor scaffolds.
Topics: Apoptosis; Biological Availability; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Drug Repositioning; Gene Expression Regulation, Neoplastic; HCT116 Cells; HeLa Cells; Humans; Piperidones; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrimidinones; Pyrroles | 2014 |
Dual Inhibition of Cdc7 and Cdk9 by PHA-767491 Suppresses Hepatocarcinoma Synergistically with 5-Fluorouracil.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Cell Cycle Proteins; Cell Line, Tumor; Checkpoint Kinase 1; Cyclin-Dependent Kinase 9; Female; Fluorouracil; Humans; Liver Neoplasms; Mice, Inbred BALB C; Mice, Nude; Molecular Targeted Therapy; Myeloid Cell Leukemia Sequence 1 Protein; Phosphorylation; Piperidones; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Pyrroles; Xenograft Model Antitumor Assays | 2015 |
Cdc7 is a potent anti-cancer target in pancreatic cancer due to abrogation of the DNA origin activation checkpoint.
Topics: Adenocarcinoma; Cell Cycle Proteins; Cell Line, Tumor; Cohort Studies; DNA Replication; G1 Phase Cell Cycle Checkpoints; Humans; Molecular Targeted Therapy; Pancreatic Neoplasms; Piperidones; Protein Serine-Threonine Kinases; Pyrroles; Transfection | 2016 |
Antiviral activity of PHA767491 against human herpes simplex virus in vitro and in vivo.
Topics: Animals; Antiviral Agents; Cell Line; Disease Models, Animal; Drug Resistance, Viral; Gene Expression Regulation, Viral; Herpes Simplex; Herpesvirus 1, Human; Herpesvirus 2, Human; Humans; Mice; Microbial Sensitivity Tests; Piperidones; Pyrroles; Viral Proteins; Virus Replication | 2017 |
DNA Replication Dynamics and Cellular Responses to ATP Competitive CDC7 Kinase Inhibitors.
Topics: Adenosine Triphosphate; Binding, Competitive; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; DNA Replication; Female; Humans; Phosphorylation; Piperidones; Protein Serine-Threonine Kinases; Pyrimidinones; Pyrroles | 2017 |
Repurposing of the CDK inhibitor PHA-767491 as a NRF2 inhibitor drug candidate for cancer therapy via redox modulation.
Topics: Antioxidants; Apoptosis; Cell Cycle Checkpoints; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinases; Drug Repositioning; Hep G2 Cells; Humans; NF-E2-Related Factor 2; Oxidation-Reduction; Oxidative Stress; Piperidones; Protein Serine-Threonine Kinases; Pyrroles; Reactive Oxygen Species; Signal Transduction | 2018 |
DDK Has a Primary Role in Processing Stalled Replication Forks to Initiate Downstream Checkpoint Signaling.
Topics: Cell Cycle Proteins; Cell Line; Dimethyl Sulfoxide; DNA Repair Enzymes; DNA Replication; DNA, Single-Stranded; Etoposide; Exodeoxyribonucleases; Humans; Mitosis; Piperidones; Protein Serine-Threonine Kinases; Pyrimidinones; Pyrroles; Signal Transduction | 2018 |
The CDK7 inhibitor THZ1 alters RNA polymerase dynamics at the 5' and 3' ends of genes.
Topics: 3' Flanking Region; 5' Flanking Region; Antineoplastic Agents; Apoptosis; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Tumor; Cell Proliferation; Cyclic N-Oxides; Cyclin-Dependent Kinase 9; Cyclin-Dependent Kinase-Activating Kinase; Cyclin-Dependent Kinases; Flavonoids; Gene Expression Regulation, Leukemic; Humans; Indolizines; Myeloid Cells; Phenylenediamines; Piperazines; Piperidines; Piperidones; Protein Kinase Inhibitors; Pyridines; Pyridinium Compounds; Pyrimidines; Pyrroles; RNA Polymerase II; Translocation, Genetic | 2019 |
Antiviral activity of PHA767491 on Caprine alphaherpesvirus 1 in vitro.
Topics: Animals; Antiviral Agents; Cell Line; DNA, Viral; Dogs; Piperidones; Pyrroles; Varicellovirus; Virus Replication | 2019 |
Targeting Inflammation, PHA-767491 Shows a Broad Spectrum in Protein Aggregation Diseases.
Topics: Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents; Cell Cycle Proteins; Cells, Cultured; Cerebellum; Cyclin-Dependent Kinase 9; DNA-Binding Proteins; Hippocampus; Humans; Mice; Mice, Inbred C57BL; Neurons; Neuroprotective Agents; Piperidones; Protein Aggregation, Pathological; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrroles | 2020 |