pyrroles has been researched along with pf 3758309 in 21 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 18 (85.71) | 24.3611 |
| 2020's | 3 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Bergqvist, S; Christensen, JG; Dagostino, E; Guo, C; Karlicek, S; Kephart, SE; Knighton, D; Kraynov, E; Lamerdin, J; Loi, CM; Marakovits, J; Martinez, R; Murray, BW; Piraino, J; Popoff, I; Smeal, T; Westwick, JK; Zager, M; Zhang, C | 1 |
| Arias-Romero, LE; Chernoff, J; Hoeflich, KP; Huang, M; Villamar-Cruz, O | 1 |
| Boggon, TJ; Calderwood, DA; Gao, J; Ha, BH; Lou, HJ; Morse, EM; Turk, BE; Zhang, R | 1 |
| Cho, JY; Choi, SW; Heo, JN; Kim, SH; Lee, H; Lee, J; Lee, SY; Ryu, BJ; Yeon, JT | 1 |
| Flores-Morales, A; Hekmat, O; Hjorth-Jensen, K; Iglesias-Gato, D; Jiang, N; Ke, B; Kruse, T; Niu, Y; Olsen, JV; Wang, C; Wei, W; Yan, B | 1 |
| Chung, JH; Han, SB; Kim, EG; Kim, JH; Shin, EY; You, ST; Yun, CY | 1 |
| Choi, SW; Heo, JC; Kim, KJ; Kim, SH; Lee, H; Lee, MS; Lee, SY; Moon, SH; Park, SJ; Ryu, BJ; Yeon, JT | 1 |
| Baskaran, Y; Manser, E; Selamat, W; Tay, PL | 1 |
| Bao, Y; Chen, Q; Feng, W; Guo, H; Lu, Y; Sun, X; Wang, X | 1 |
| Babu, N; Balaji, SA; Chang, X; Chatterjee, A; Datta, KK; Gowda, H; Izumchenko, E; Nanjappa, V; Pandey, A; Patil, AH; Prasad, TS; Puttamallesh, VN; Radhakrishnan, A; Raja, R; Rangarajan, A; Renuse, S; Sahasrabuddhe, NA; Sidransky, D; Solanki, HS; Syed, N | 1 |
| Ding, Y; Feng, J; Fu, X; Yang, B; Yu, C; Zeng, D | 1 |
| Babagana, M; Bshara, W; Johnson, S; Kandel, ES; Morrison, C; Slabodkin, H | 1 |
| Baldwin, GS; Dumesny, CJ; He, H; Huynh, N; Nikfarjam, M; Sandrin, MS; Wang, K; Yim, M | 1 |
| Chen, X; Ding, X; Du, W; Fang, F; Hu, S; Li, M; Li, X; Li, Z; Lu, J; Pan, J; Qian, G; Ren, J; Tao, Y; Wang, J; Wu, Y; Xu, L; Xu, Y; Yang, C; Zhao, H | 1 |
| Baldwin, G; He, H; Huynh, N; Nikfarjam, M; Wang, K; Wang, X | 1 |
| Giacobbi, NS; Gupta, P; Han, F; Sanyal, A; Sluis-Cremer, N; Vargas, B; Venkatachari, NJ | 1 |
| Bartholdy, B; Chung, EY; Ishida, E; Janakiram, M; Kataoka, K; Mai, Y; Ogawa, S; Pradhan, K; Ren, X; Shah, UA; Steidl, U; Verma, A; Wei, X; Wei, Y; Ye, BH; Zang, X; Zhang, J; Zou, Y | 1 |
| He, YT; Luo, SM; Shen, W; Sun, QY; Yang, LL; Yin, S | 1 |
| Du, YY; Gu, KS; Jiao, Y; Lei, Y; Liu, WT; Wei, W; Zhan, MN; Zhang, CJ; Zhang, TT; Zhang, YY; Zhao, CC | 1 |
| Coarfa, C; Dasgupta, A; Kurenbekova, L; Landesman, Y; Patel, T; Rainusso, N; Rajapakse, K; Shuck, RL; Sierra, L; Tsang, SV; Unger, T; Yustein, JT | 1 |
| Coarfa, C; Kim, HR; Kurenbekova, L; Landesman, Y; Nakahata, K; Patel, TD; Qasim, SL; Rajapakshe, K; Shuck, R; Sierra, L; Unger, TJ; Wulff, J; Yustein, JT | 1 |
21 other study(ies) available for pyrroles and pf 3758309
| Article | Year |
|---|---|
Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth.
Topics: Cell Line, Tumor; Cell Proliferation; Cell Survival; Crystallography; Guanine Nucleotide Exchange Factors; Humans; Models, Molecular; Neoplasms; p21-Activated Kinases; Phosphorylation; Pyrazoles; Pyrroles; Rho Guanine Nucleotide Exchange Factors; Signal Transduction | 2010 |
Pak1 kinase links ErbB2 to β-catenin in transformation of breast epithelial cells.
Topics: Animals; Apoptosis; beta Catenin; Blotting, Western; Breast Neoplasms; Cell Line; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Dose-Response Relationship, Drug; Epithelial Cells; Humans; Mice; Mice, Inbred ICR; Mice, Knockout; Mice, SCID; Mice, Transgenic; p21-Activated Kinases; Pyrazoles; Pyrroles; Receptor, ErbB-2; RNA Interference; Xenograft Model Antitumor Assays | 2013 |
Substrate and inhibitor specificity of the type II p21-activated kinase, PAK6.
Topics: Amino Acid Sequence; Catalytic Domain; Crystallization; Crystallography, X-Ray; HEK293 Cells; Humans; Indoles; Models, Molecular; Molecular Sequence Data; p21-Activated Kinases; Peptide Fragments; Phosphorylation; Protein Conformation; Pyrazoles; Pyrroles; Sequence Homology, Amino Acid; Signal Transduction; Substrate Specificity; Sunitinib | 2013 |
PF-3758309, p21-activated kinase 4 inhibitor, suppresses migration and invasion of A549 human lung cancer cells via regulation of CREB, NF-κB, and β-catenin signalings.
Topics: beta Catenin; Cell Line, Tumor; Cell Movement; Cyclic AMP Response Element-Binding Protein; Down-Regulation; Extracellular Matrix; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neoplasm Invasiveness; NF-kappa B; p21-Activated Kinases; Pyrazoles; Pyrroles; Signal Transduction | 2014 |
In vivo quantitative phosphoproteomic profiling identifies novel regulators of castration-resistant prostate cancer growth.
Topics: Androgens; Animals; Cell Line, Tumor; Cell Proliferation; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Phosphorylation; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Proteome; Proteomics; Pyrazoles; Pyrroles; Receptors, Androgen; Signal Transduction | 2015 |
p21-activated kinase 4 critically regulates melanogenesis via activation of the CREB/MITF and β-catenin/MITF pathways.
Topics: alpha-MSH; Animals; beta Catenin; Cell Line, Tumor; CREB-Binding Protein; Dose-Response Relationship, Radiation; Humans; In Vitro Techniques; Melanins; Melanocytes; Mice; Mice, Hairless; Microphthalmia-Associated Transcription Factor; p21-Activated Kinases; Pyrazoles; Pyrroles; RNA Interference; Signal Transduction; Ultraviolet Rays | 2015 |
Repositioning Potential of PAK4 to Osteoclastic Bone Resorption.
Topics: Animals; Bone Marrow Cells; Bone Resorption; Cell Differentiation; Disease Models, Animal; Humans; Lipopolysaccharides; Male; Mice; Mice, Inbred ICR; Osteoclasts; p21-Activated Kinases; Pyrazoles; Pyrroles | 2015 |
The Cdc42 Effector Kinase PAK4 Localizes to Cell-Cell Junctions and Contributes to Establishing Cell Polarity.
Topics: beta Catenin; cdc42 GTP-Binding Protein; Cell Line, Tumor; Cell Polarity; Gene Knockdown Techniques; Humans; Intercellular Junctions; MCF-7 Cells; p21-Activated Kinases; Phosphorylation; Protein Kinase Inhibitors; Pyrazoles; Pyrroles; Serine | 2015 |
A two kinase-gene signature model using CDK2 and PAK4 expression predicts poor outcome in non-small cell lung cancers.
Topics: Aged; Carcinoma, Non-Small-Cell Lung; Cyclin-Dependent Kinase 2; Disease-Free Survival; Female; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Lung Neoplasms; Male; Middle Aged; p21-Activated Kinases; Pyrazoles; Pyrroles; Tissue Array Analysis; Treatment Outcome | 2016 |
Chronic exposure to cigarette smoke leads to activation of p21 (RAC1)-activated kinase 6 (PAK6) in non-small cell lung cancer cells.
Topics: Animals; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cell Survival; ErbB Receptors; Gene Silencing; Humans; Lung Neoplasms; Male; Mice; Mice, Inbred NOD; Mice, SCID; Neoplasm Transplantation; p21-Activated Kinases; Phosphorylation; Proteome; Pyrazoles; Pyrroles; rac1 GTP-Binding Protein; RNA, Small Interfering; Signal Transduction; Smoke; Tobacco Products | 2016 |
PAK4 confers cisplatin resistance in gastric cancer cells via PI3K/Akt- and MEK/ERK-dependent pathways.
Topics: Animals; Cell Line, Tumor; Chromones; Cisplatin; Drug Resistance, Neoplasm; Humans; MAP Kinase Signaling System; Mice; Mice, Nude; Morpholines; p21-Activated Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrazoles; Pyrroles; Stomach Neoplasms; Xenograft Model Antitumor Assays | 2014 |
P21-activated kinase 1 regulates resistance to BRAF inhibition in human cancer cells.
Topics: Cell Line, Tumor; Drug Resistance, Neoplasm; Enzyme Inhibitors; Humans; Indoles; Melanoma; Molecular Targeted Therapy; p21-Activated Kinases; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-akt; Pyrazoles; Pyrroles; rac1 GTP-Binding Protein; Sulfonamides; Vemurafenib | 2017 |
Depletion of p21-activated kinase 1 up-regulates the immune system of APC
Topics: Animals; Biomarkers; Cell Line, Tumor; Cell Transformation, Neoplastic; Colorectal Neoplasms; Disease Models, Animal; Genes, APC; Genotype; Immune System; Immunohistochemistry; Immunomodulation; Leukocyte Count; Lymphocytes; Mice; Mice, Knockout; Neutrophils; p21-Activated Kinases; Polycomb Repressive Complex 1; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Pyrazoles; Pyrroles | 2017 |
Inhibition of neuroblastoma proliferation by PF-3758309, a small-molecule inhibitor that targets p21-activated kinase 4.
Topics: Adult; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Female; Gene Expression Regulation, Neoplastic; Humans; Male; MAP Kinase Signaling System; Neoplasm Staging; Neuroblastoma; p21-Activated Kinases; Protein Kinase Inhibitors; Pyrazoles; Pyrroles; Up-Regulation | 2017 |
Inhibition of p21 activated kinase enhances tumour immune response and sensitizes pancreatic cancer to gemcitabine.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Pancreatic Ductal; Cell Movement; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Deoxycytidine; Drug Synergism; Gemcitabine; Humans; Male; Mice; Mice, Inbred C57BL; Pancreatic Neoplasms; Protein Kinase Inhibitors; Pyrazoles; Pyrroles; Random Allocation | 2018 |
Inhibitors of Signaling Pathways That Block Reversal of HIV-1 Latency.
Topics: Anti-HIV Agents; Benzamides; CD4-Positive T-Lymphocytes; Cell Line; HIV Infections; HIV-1; Humans; Pyrazoles; Pyrroles; Signal Transduction; Virus Activation | 2019 |
PAK Kinase Inhibition Has Therapeutic Activity in Novel Preclinical Models of Adult T-Cell Leukemia/Lymphoma.
Topics: Adult; Animals; Cell Adhesion; Cell Adhesion Molecule-1; Cell Line, Tumor; Cell Proliferation; Female; Gene Amplification; Humans; Leukemia-Lymphoma, Adult T-Cell; Mice; Mice, Inbred NOD; Mice, SCID; p21-Activated Kinases; Primary Cell Culture; Protein Kinase Inhibitors; Pyrazoles; Pyrroles; RNA, Small Interfering; Survival Rate; Xenograft Model Antitumor Assays | 2019 |
PAK4 Regulates Actin and Microtubule Dynamics during Meiotic Maturation in Mouse Oocyte.
Topics: Actins; Animals; Centrosome; Chromosome Segregation; Female; Kinetochores; Meiosis; Mice; Microtubules; Oocytes; p21-Activated Kinases; Pyrazoles; Pyrroles | 2019 |
Combined LIM kinase 1 and p21-Activated kinase 4 inhibitor treatment exhibits potent preclinical antitumor efficacy in breast cancer.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Drug Synergism; Female; Gene Expression Regulation, Neoplastic; Humans; Lim Kinases; MAP Kinase Signaling System; Mice; p21-Activated Kinases; Phosphorylation; Pyrazoles; Pyrroles; Thiazoles; Xenograft Model Antitumor Assays | 2020 |
Targeting PAK4 Inhibits Ras-Mediated Signaling and Multiple Oncogenic Pathways in High-Risk Rhabdomyosarcoma.
Topics: Acrylamides; Aminopyridines; Animals; Apoptosis; Biomarkers, Tumor; Cell Movement; Cell Proliferation; Child; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; p21-Activated Kinases; Pyrazoles; Pyrroles; ras Proteins; Rhabdomyosarcoma; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2021 |
p21-activated kinases as viable therapeutic targets for the treatment of high-risk Ewing sarcoma.
Topics: Acrylamides; Aminopyridines; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Gene Expression Regulation, Neoplastic; Humans; Interferon-alpha; Interferon-gamma; p21-Activated Kinases; Pyrazoles; Pyrroles; Sarcoma, Ewing; Signal Transduction; Xenograft Model Antitumor Assays | 2021 |