Page last updated: 2024-08-18

pyrroles and pexidartinib

pyrroles has been researched along with pexidartinib in 104 studies

Research

Studies (104)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	48 (46.15)	24.3611
2020's	56 (53.85)	2.80

Authors

Authors	Studies
Antonescu, CR; Besmer, P; Cavnar, MJ; Cohen, NA; Crawley, MH; Dematteo, RP; Green, BL; Greer, JB; Kim, TS; Ku, AT; Pillarsetty, N; Popow, R; Rossi, F; Seifert, AM; Sorenson, EC; Veach, DR; Zeng, S	1
Beckman, MJ; de Stanchina, E; Dematteo, RP; Patwardhan, PP; Schwartz, GK; Surriga, O; Tap, WD	1
Galanis, A; Levis, M	1
Bashir, A; Bollag, G; Burton, EA; Carias, H; Damon, LE; Habets, G; Hsu, HH; Ibrahim, PN; Kasarskis, A; Lasater, EA; Le, MH; Lin, KC; Massi, E; Matusow, B; Pendleton, M; Perl, A; Powell, B; Sebra, R; Shah, NP; Shellooe, R; Smith, CC; Spevak, W; Tsang, G; West, BL; Zhang, C; Zhang, J; Zhang, Y	1
Arens, R; Melief, CJ; Sluijter, M; van der Burg, SH; van der Sluis, TC; van Duikeren, S; van Hall, T; West, BL	1
Bollag, G; Graeber, TG; Hu-Lieskovan, S; Koya, RC; Mok, S; Ribas, A; Tsoi, J; West, BL	1
Burton, EA; Chartier, S; Habets, G; Jimenez-Andrade, JM; Lin, PS; Mantyh, PW; Thompson, ML; Tsai, J; West, BL	1
Arora, RP; Green, KN; Hernandez, MX; Lee, RJ; Rice, RA; Spangenberg, EE; Tenner, AJ; West, BL; Yamate-Morgan, H	1
Anthony, SP; Bollag, G; Burton, EA; Chmielowski, B; Cohn, AL; Gee, C; Habets, G; Healey, JH; Hirth, P; Hsu, HH; Ibrahim, PN; Keedy, VL; Kim, MJ; Kwak, EL; Lin, PS; Marimuthu, A; Nguyen, H; Nolop, K; Peterfy, C; Puzanov, I; Ramanathan, RK; Sanftner, L; Severson, P; Shapiro, GI; Shellooe, R; Singh, AS; Staddon, AP; Tap, WD; Tong-Starksen, S; Tsang, G; van de Rijn, M; Visor, G; Von Hoff, DD; Wagner, AJ; Wainberg, ZA; Weiss, GJ; West, BL; Zhang, C; Zhang, J; Zhang, Y	1
Butowski, N; Cloughesy, TF; Colman, H; De Groot, JF; Haidar, S; Hsu, HH; Huse, J; Ligon, KL; Marimuthu, A; Molinaro, AM; Nayak, L; Nolop, KB; Omuro, AM; Perry, A; Phillips, J; Prados, M; Wen, PY; West, BL	1
Cunyat, F; McCune, JM; Rainho, JN; Stevenson, M; Swainson, L; West, B	1
Baier, F; Bise, T; de Preux Charles, AS; Jaźwińska, A; Marro, J	1
Feng, X; Gupta, N; Jopson, TD; Liu, S; Paladini, MS; Rosi, S; West, BL	1
Jin, WN; Li, M; Li, Z; Liu, Q; Ren, H; Sheth, KN; Shi, FD; Wood, K	1
Cuccarese, MF; Dubach, JM; Engblom, C; Garris, C; Miller, MA; Pfirschke, C; Pittet, MJ; Weissleder, R	1
Gonzales, RJ; Jin, WN; Li, M; Li, Z; Liu, Q; Shi, SX; Wood, K	1
Aerts, JG; Bezemer, K; Dammeijer, F; Hegmans, JP; Hendriks, RW; Kaijen-Lambers, ME; Lievense, LA; van Hall, T; van Nimwegen, M	1
Cvetanovic, M; Johnson, A; Kim, JH; Lukowicz, A; Qu, W; Svedberg, D	1
Ao, JY; Cai, H; Chai, ZT; Kong, LQ; Ma, DN; Sun, HC; Ye, BG; Zhang, KZ; Zhang, N; Zhang, YY; Zhu, XD	1
Akkari, L; Huse, JT; Joyce, JA; Kowal, J; Schuhmacher, AJ; West, BL; Yan, D	1
Li, M; Liu, Q; Ma, C; Qiu, S; Ren, H; Shi, FD; Wood, K; Yang, X	1
Canter, RG; Dominique, MA; Fang, TC; Khan, T; Lee, VM; Miller, KR; Ransohoff, RM; Restrepo, CR; Roberts, CJ; Spiller, KJ; Trojanowski, JQ	1
Albay, R; Baglietto-Vargas, D; Glabe, CG; LaFerla, FM; Philipp, S; Reyes-Ruiz, JM; Sosna, J	1
Alifano, M; Barrin, S; Bercovici, N; Biton, J; Damotte, D; Donnadieu, E; Feuillet, V; Guérin, M; Kantari-Mimoun, C; Lemoine, J; Lupo, A; Ouakrim, H; Peranzoni, E; Régnier, F; Vimeux, L	1
Alberti, L; Blay, JY; Brahmi, M; Cassier, P; Eberst, L; Karanian, M; Pissaloux, D; Tirode, F	1
Grant, FM; Gyori, D; Hawkins, PT; Lim, EL; Okkenhaug, K; Roychoudhuri, R; Shuttleworth, SJ; Spensberger, D; Stephens, LR	1
Hara, H; Kuse, Y; Nakamura, S; Ohuchi, K; Shimazawa, M	1
Crapser, J; Green, KN; Jiang, S; Mortazavi, A; Najafi, AR; Ng, W; West, BL	1
Eto, K; Kashiwagi, K; Koizumi, S; Nabekura, J; Ohno, N; Shinozaki, Y; Takeda, A; Wake, H	1
Bollag, G; Guan, W; Hu, J; Tan, P; Tang, Z; West, BL; Wu, L; Xu, H; Yang, L	1
Bennett, RE; Bryant, A; Hopp, SC; Hu, M; Hyman, BT; Robbins, AB	1
Cheng, L; Dai, L; Deng, H; Jiang, Q; Li, J; Li, Y; Li, Z; Lin, Y; Liu, L; Liu, Y; Shi, G; Su, X; Wang, H; Wang, Q; Wei, Y; Yang, Q; Yang, S; Yang, Y; Yu, D; Zhang, H; Zhang, S; Zhang, X; Zhang, Y	1
Berve, K; Groh, J; Klein, D; Martini, R; West, BL	1
Luo, Q; Qian, Y; Qiao, S; Xu, G; Zhang, Z	1
Barati, S; Kashani, IR; Madadi, S; Mortezaee, K; Pasbakhsh, P; Tahmasebi, F	1
Amato, LB; Baldassarre, M; Bridgeman, VL; Columbaro, M; Cossarizza, A; De Luise, M; Feichtinger, RG; Foriel, S; Gasparre, G; Gibellini, L; Girolimetti, G; Grifoni, D; Iommarini, L; Kofler, B; Kurelac, I; Leone, G; Malanchi, I; Ombrato, L; Porcelli, AM; Ragazzi, M; Sollazzo, M; Umesh Ganesh, N; Vatrinet, R; Vidali, S; Vidone, M	1
Chen, TW; Cheng, AL; Chiu, LL; Hsu, CH; Ishizuka, T; Lee, JH; Lin, CC; Oguma, T; Sasaki, SI; Sugihara, M; Tajima, N; Yang, JC; Yen, YH	1
Hyun, H; Lyle, LT; Pang, L; Pei, Y; Uzunalli, G; Yeo, Y	1
Dong, QZ; Gao, XM; Hsu, JL; Hung, MC; Jia, HL; Li, CW; Li, JH; Lim, SO; Lu, L; Luo, Q; Qin, LX; Sheng, YY; Xu, D; Yang, J; Zhang, Y; Zhang, Z; Zhao, Y; Zheng, Y; Zhu, Y	1
Adams, SE; Brooks, AES; Jaiswal, JK; Jamieson, SMF; Masson, SW; Merry, TL; Shepherd, PR	1
Bennett, JL; Dickson, EL; Given, KS; Liu, Y; Macklin, WB; Owens, GP	1
Ge, XT; Guo, JX; Li, CL; Li, TY; Lv, F; Wang, XF; Wang, YJ	1
Ducruet, AF; Lawton, MT; Qiu, S; Sheth, KN; Shi, E; Shi, K	1
Jue, L; Li, X; Pang, X; Wang, S	1
Adamson, T; Antonescu, CR; Chi, P; Condy, M; D'Angelo, SP; Dickson, MA; Gounder, M; Hwang, S; Kelly, C; Keohan, ML; Mcfadyen, CR; Movva, S; Qin, LX; Rosenbaum, E; Singer, S; Tap, WD	1
Boussioutas, A; Brunnberg, J; Buchert, M; Dijkstra, C; Eissmann, MF; Ernst, M; Etemadi, N; Grimbaldeston, MA; Hibbs, ML; Huntington, ND; Jarnicki, A; Masson, F; O'Donoghue, RJJ; Phesse, T; Poh, AR; Thiem, S; Tsantikos, E	1
Holtzman, DM; Hoyle, R; Long, J; Manis, M; Remolina Serrano, J; Shi, Y; Sullivan, PM; Wang, K	1
Lamb, YN	1
Bailey, NG; Brown, NA; Chowdhury, P; Dewar, H; Dewar, R; Elenitoba-Johnson, KSJ; Inamdar, K; Lim, MS; Murga-Zamalloa, C; Onder, O; Polk, A; Rolland, DCM; Wilcox, RA; Wolfe, A	1
Cong, L; Dong, J; Ke, M; Li, Y; Lv, Y; Wang, X; Zhang, Z; Zhao, S; Zhu, Y	1
Aplin, AE; Chervoneva, I; Erkes, DA; Field, CO; Rosenbaum, SR; Villanueva, J	1
Abdel-Wahab, O; Abramson, D; Arcila, ME; Berger, MF; Ceyhan-Birsoy, O; De Munck, S; Decaux, O; Diamond, EL; Drilon, A; Dunkel, IJ; Durham, BH; Emile, JF; Erickson, C; Geissmann, F; Haroche, J; Hyman, DM; Ki, M; Lacouture, ME; Ladanyi, M; Lopez Rodrigo, E; Lu, SX; Mandelker, D; Mora, J; Pannecoucke, E; Pastore, A; Petrova-Drus, K; Picarsic, J; Rotemberg, V; Saganty, R; Santa-María López, V; Savvides, SN; Solit, DB; Ulaner, GA; Walsh, M; Yabe, M; Yoshimi, A	1
Crapser, JD; Green, KN; Ochaba, J; Reidling, JC; Soni, N; Thompson, LM	1
Bjelic, S; Friedman, R; Georgoulia, PS	1
Cano, M; Gad, M; Green, KN; Leslie, FM; Linker, KE; Tawadrous, P; Wood, MA	1
Coleman, LG; Crews, FT; Zou, J	1
Brazina, S; Clark, D; Hsieh, CL; Hu, D; Marcucio, R; Miclau, T; Nakamura, MC; Niemi, EC; Yang, F	1
Crosby, MR; Hudson, WA; Laoharawee, K; Largaespada, DA; Larsson, AT; Mills, LJ; Moriarity, BS; Osum, SH; Peterson, JJ; Pomeroy, EJ; Rahrmann, EP; Rathe, SK; Slipek, NJ; Smeester, BA; Stratton, N; Wang, M; Williams, KB; Yamamoto, K	1
Donati, DM; Longhi, A; Palmerini, E; Staals, EL	1
Bollag, G; Frankfurt, O; Hsu, HH; Kayser, S; Lam, B; Le, MH; Levis, MJ; Pagel, JM; Perl, AE; Roboz, GJ; Severson, PL; Smith, CC; Stone, RM; Wang, ES; West, BL; Zhang, C	1
Cai, Z; Chen, Z; Huang, C; Lu, J; Lu, X; Tong, L; Wang, D; Ye, T; Yuan, X	1
Benner, B; Carson, WE; Cherian, MA; Good, L; Kassem, M; Quiroga, D; Sardesai, S; Schultz, TE; Wesolowski, R	1
Baldi, GG; Gronchi, A; Stacchiotti, S	1
Jiang, Z; Shi, L; Tang, C; Xu, RA; Zhang, B	1
Lazaridis, D; Monestime, S	1
de Sande, MV; Gelderblom, H	1
Tap, W	1
Choi, HD; Choi, JY; Jeong, YJ; Lee, HJ; Nam, KR; Oh, SJ; Shin, NR; Son, Y	1
Babiker, HM; Gajee, R; Gordon, MS; Greenberg, J; Kobayashi, F; Wagner, AJ; Wang, Q; Zahir, H; Zamora, C	1
Barati, S; Kashani, IR; Madadi, S; Pasbakhsh, P; Tahmasebi, F	1
Bartolucci, M; Cancedda, L; Catelani, T; Contestabile, A; Fumagalli, A; Morelli, G; Perlini, LE; Petretto, A; Pinto, B; Rastogi, M; Savardi, A; Varea, E	1
Gelderblom, H; Healey, JH; Kang, J; Knebel, W; Shuster, D; Stacchiotti, S; Tap, WD; van de Sande, M; Wagner, AJ; Yin, O; Zahir, H	1
Berve, K; Groh, J; Martini, R; West, BL	1
Alsayadi, YMMA; Chawla, PA	1
Alhudaithi, SS; Almuqbil, RM; Bielski, ER; Bos, PD; da Rocha, SRP; Du, W; Sunbul, FS; Zhang, H	1
Bernthal, NM; Desai, J; Frezza, AM; Gelderblom, H; Healey, JH; Hsu, HH; Palmerini, E; Peterfy, CG; Shuster, DE; Staals, EL; Stacchiotti, S; Tap, WD; van de Sande, MAJ; Wagner, AJ; Wainberg, ZA; Wang, Q	1
Baba, HA; Bauer, S; Choi, Y; Druta, M; Gelderblom, H; Healey, JH; Lewis, JH; Lin, CC; Pousa, AL; Shuster, DE; Stacchiotti, S; Tap, WD; van de Sande, M; Wagner, AJ; Wang, Q	1
Green, KN; Holmes, TC; Liu, YJ; Spangenberg, EE; Tang, B; Xu, X	1
Hong, JS; Hou, L; Jing, L; Li, S; Peng, B; Ruan, Z; Wang, Q; Zhang, D; Zhang, X; Zhao, J	1
Drogaris, L; Henderson, M; Islam, Z; Julian, M; O'Donnell, N; Salas, M; Stemhagen, A; Tu, N	1
Boehm-Sturm, P; Brandenburg, S; Heinz, R; Kremenetskaia, I; Nieminen-Kelhä, M; Schneider, UC; Vajkoczy, P	1
Boyd, MM; Collier, LS; Hagemann, TL; Litscher, SJ; Messing, A; Seitz, LL	1
Miyata, M; Ueta, Y	1
Arenas, F; Balagué, O; Campo, E; Capdevila, C; Carreras, J; Cid, MC; Colomer, D; Guerrero-Hernández, M; Hernández, L; López-Guillermo, A; Magnano, L; Martin, S; Matas-Céspedes, A; Pérez-Galán, P; Rivas-Delgado, A; Rodriguez, V; Serrat, N; Tannheimer, S; Valero, JG; Yahiaoui, A	1
Alcindor, T; Desai, J; Ganjoo, K; Gelderblom, H; Gelhorn, HL; Healey, JH; Martín-Broto, J; Palmerini, E; Shuster, D; Speck, RM; Stacchiotti, S; Tap, WD; Van De Sande, M; Wagner, AJ; Wang, Q; Ye, X	1
Barati, S; Kashani, IR; Tahmasebi, F	1
Ci, L; Dong, H; Fei, J; Huang, F; Li, Q; Liu, Z; Ma, Y; Shen, C; Shen, R; Sun, R; Wang, J; Wang, Z; Yu, M; Zhang, X	1
Chen, A; Hirbe, AC; Lee, SM; Manji, GA; Pellicciotta, I; Pradhan, J; Rabadan, R; Raufi, AG; Schwartz, GK; Van Tine, BA	1
Shen, Q; Zhang, G	1
da Silva, AM; da Silva, MCM; de Barros Fernandes, H; de Miranda, AS; de Oliveira, ACP; Gomes, GF; Moreira, FA; Teixeira, AL	1
Baczynska, E; Baidoe-Ansah, D; Cangalaya, C; Dityatev, A; Kaushik, R; Strackeljan, L; Wlodarczyk, J	1
Almonte, VM; Egaña-Gorroño, L; Jayakumar, S; Oliveira-Paula, GH; Parikh, D; Riascos-Bernal, DF; Sibinga, NES; Uriyanghai, U; Zhang, J	1
French, J; Gelderblom, H; Greenberg, J; Healey, JH; Polhamus, D; Shuster, D; Stacchiotti, S; Tap, WD; van de Sande, M; Wagner, AJ; Wang, X; Yin, O; Zahir, H	1
Beckett, B; Hansford, B; Helming, A	1
Chen, Y; Gao, M; Guo, Y; Jiang, M; Li, T; Liu, H; Qu, Y; Sun, X; Wan, X; Wang, F; Wang, Y; Zhao, X	1
Anthony, SP; Braiteh, F; Chmielowski, B; Cohn, AL; Cote, GM; Gelhorn, HL; Healey, JH; Hsu, HH; Keedy, VL; Lin, PS; Peterfy, C; Puzanov, I; Severson, P; Shapiro, GI; Sherman, E; Singh, AS; Sterba, M; Tap, WD; Tong-Starksen, S; Wagner, AJ; Wainberg, ZA; West, BL; Ye, X; Zhang, C	1
Bode-Böger, SM; Feist, E; Martens-Lobenhoffer, J; Tomaras, S	1
Abeykoon, JP; Bennani, NN; Dasari, S; Davidge-Pitts, CJ; Flanagan, EP; Go, RS; Goyal, G; Koster, MJ; Lasho, TL; Manske, MK; Nowakowski, KE; Patnaik, MM; Ranatunga, WK; Ravindran, A; Rech, KL; Ruan, GJ; Ryu, JH; Shah, MV; Tischer, A; Tobin, WO; Vassallo, R; Witzig, TE; Wu, X; Young, JR	1
Asiri, YA; Ezzeldin, E; Iqbal, M; Mostafa, GAE; Sayed, AYA	1
Gao, X; Han, Z; Lei, P; Li, M; Li, X; Liu, M; Liu, Q; Zhang, W	1
Choi, Y; Dharmani, C; Diggs, A; Jiang, J; Keedy, VL; McCabe, C; Salas, M; Wang, E	1
Greenberg, J; Healey, JH; Hsu, C; LaCreta, F; Lasseter, KC; Marbury, TC; Stacchiotti, S; Tap, WD; Xu, LA; Zahir, H	1
Appel, D; Hummel, R; Klein, M; Li, S; Ritter, K; Schäfer, MKE; Strehle, J; Tegeder, I; Wang, Y; Wernersbach, I	1
Damron, TA	1

Reviews

8 review(s) available for pyrroles and pexidartinib

Article	Year
Pexidartinib: First Approval. Drugs, 2019, Volume: 79, Issue:16 Topics: Aminopyridines; Antineoplastic Agents; Drug Approval; fms-Like Tyrosine Kinase 3; Giant Cell Tumor of Tendon Sheath; Humans; Macrophage Colony-Stimulating Factor; Protein Kinase Inhibitors; Proto-Oncogene Mas; Proto-Oncogene Proteins c-kit; Pyrroles; United States; United States Food and Drug Administration	2019
Pexidartinib for the treatment of adult patients with symptomatic tenosynovial giant cell tumor: safety and efficacy. Expert review of anticancer therapy, 2020, Volume: 20, Issue:6 Topics: Adult; Aminopyridines; Antineoplastic Agents; Chemical and Drug Induced Liver Injury; Giant Cell Tumor of Tendon Sheath; Humans; Macrophage Colony-Stimulating Factor; Neoplasm Recurrence, Local; Pyrroles; Quality of Life	2020
Pexidartinib, a Novel Small Molecule CSF-1R Inhibitor in Use for Tenosynovial Giant Cell Tumor: A Systematic Review of Pre-Clinical and Clinical Development. Drug design, development and therapy, 2020, Volume: 14 Topics: Aminopyridines; Antineoplastic Agents; Clinical Trials as Topic; Dose-Response Relationship, Drug; Giant Cell Tumor of Tendon Sheath; Humans; Molecular Structure; Pyrroles; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Structure-Activity Relationship	2020
Pexidartinib for the treatment of adult symptomatic patients with tenosynovial giant cell tumors. Expert review of clinical pharmacology, 2020, Volume: 13, Issue:6 Topics: Adult; Aminopyridines; Antineoplastic Agents; Giant Cell Tumor of Tendon Sheath; Humans; Macrophage Colony-Stimulating Factor; Neoplasm Recurrence, Local; Pyrroles; Quality of Life; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor	2020
Pexidartinib (TURALIO™): The First FDA-Indicated Systemic Treatment for Tenosynovial Giant Cell Tumor. Drugs in R&D, 2020, Volume: 20, Issue:3 Topics: Administration, Oral; Adult; Aminopyridines; Antineoplastic Agents; Clinical Trials as Topic; Contraindications, Drug; Drug Approval; Drug Interactions; Female; Giant Cell Tumor of Tendon Sheath; Humans; Macrophage Colony-Stimulating Factor; Male; Middle Aged; Protein Kinase Inhibitors; Pyrroles; United States; United States Food and Drug Administration	2020
Pexidartinib: first approved systemic therapy for patients with tenosynovial giant cell tumor. Future oncology (London, England), 2020, Volume: 16, Issue:29 Topics: Aminopyridines; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Diagnostic Imaging; Disease Management; Giant Cell Tumor of Tendon Sheath; Humans; Molecular Targeted Therapy; Neoplasm Staging; Protein Kinase Inhibitors; Pyrroles; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Structure-Activity Relationship; Treatment Outcome	2020
Prospects of Treating Tenosynovial Giant Cell Tumor through Pexidartinib: A Review. Anti-cancer agents in medicinal chemistry, 2021, Volume: 21, Issue:12 Topics: Aminopyridines; Antineoplastic Agents; Giant Cell Tumor of Tendon Sheath; Humans; Macrophage Colony-Stimulating Factor; Pyrroles; Receptor, Macrophage Colony-Stimulating Factor; United States; United States Food and Drug Administration	2021
Turalio risk evaluation and mitigation strategy for treatment of tenosynovial giant cell tumor: framework and experience. Future oncology (London, England), 2022, Volume: 18, Issue:13 Topics: Adult; Aminopyridines; Giant Cell Tumor of Tendon Sheath; Humans; Pyrroles; Risk Evaluation and Mitigation; United States; United States Food and Drug Administration	2022

Trials

8 trial(s) available for pyrroles and pexidartinib

Article	Year
Structure-Guided Blockade of CSF1R Kinase in Tenosynovial Giant-Cell Tumor. The New England journal of medicine, 2015, Jul-30, Volume: 373, Issue:5 Topics: Adult; Aged; Aminopyridines; Crystallography, X-Ray; Dose-Response Relationship, Drug; Drug Discovery; Female; Giant Cell Tumors; Humans; Male; Middle Aged; Pyrroles; Receptor, Macrophage Colony-Stimulating Factor; Soft Tissue Neoplasms; Tendons; Tumor Burden	2015
Orally administered colony stimulating factor 1 receptor inhibitor PLX3397 in recurrent glioblastoma: an Ivy Foundation Early Phase Clinical Trials Consortium phase II study. Neuro-oncology, 2016, Volume: 18, Issue:4 Topics: Administration, Oral; Aminopyridines; Biomarkers, Tumor; Blood-Brain Barrier; Brain Neoplasms; Cohort Studies; Female; Follow-Up Studies; Glioblastoma; Humans; Immunoenzyme Techniques; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Prognosis; Pyrroles; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Tissue Distribution; Tumor Burden	2016
A phase I study of pexidartinib, a colony-stimulating factor 1 receptor inhibitor, in Asian patients with advanced solid tumors. Investigational new drugs, 2020, Volume: 38, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Aminopyridines; Biomarkers, Tumor; Female; Follow-Up Studies; Humans; Male; Maximum Tolerated Dose; Middle Aged; Neoplasms; Non-Randomized Controlled Trials as Topic; Prognosis; Pyrroles; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Tissue Distribution; Young Adult	2020
A Phase I Study of Binimetinib (MEK162) Combined with Pexidartinib (PLX3397) in Patients with Advanced Gastrointestinal Stromal Tumor. The oncologist, 2019, Volume: 24, Issue:10 Topics: Aged; Aminopyridines; Antineoplastic Combined Chemotherapy Protocols; Benzimidazoles; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Synergism; Female; Gastrointestinal Neoplasms; Gastrointestinal Stromal Tumors; Humans; Male; Maximum Tolerated Dose; Middle Aged; Pyrroles; Tissue Distribution	2019
A phase 1/2 study of the oral FLT3 inhibitor pexidartinib in relapsed/refractory FLT3-ITD-mutant acute myeloid leukemia. Blood advances, 2020, 04-28, Volume: 4, Issue:8 Topics: Aminopyridines; fms-Like Tyrosine Kinase 3; Humans; Leukemia, Myeloid, Acute; Phenylurea Compounds; Protein Kinase Inhibitors; Pyrroles	2020
Evaluation of Potential Drug-Drug Interaction Risk of Pexidartinib With Substrates of Cytochrome P450 and P-Glycoprotein. Journal of clinical pharmacology, 2021, Volume: 61, Issue:3 Topics: Adult; Aged; Aminopyridines; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cross-Over Studies; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Drug Interactions; Female; Humans; Male; Middle Aged; Pyrroles	2021
Population Pharmacokinetic Analysis of Pexidartinib in Healthy Subjects and Patients With Tenosynovial Giant Cell Tumor or Other Solid Tumors. Journal of clinical pharmacology, 2021, Volume: 61, Issue:4 Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Aminopyridines; Antineoplastic Agents; Area Under Curve; Asian People; Bacterial Proteins; Body Weight; Creatinine; Female; Giant Cell Tumor of Tendon Sheath; Humans; Kidney Function Tests; Liver Function Tests; Male; Metabolic Clearance Rate; Middle Aged; Models, Biological; Pyrroles; Racial Groups; Sex Factors; Sociodemographic Factors; Tumor Burden; Young Adult	2021
Pexidartinib improves physical functioning and stiffness in patients with tenosynovial giant cell tumor: results from the ENLIVEN randomized clinical trial. Acta orthopaedica, 2021, Volume: 92, Issue:4 Topics: Adult; Aminopyridines; Double-Blind Method; Female; Giant Cell Tumor of Tendon Sheath; Humans; Lower Extremity; Male; Middle Aged; Patient Reported Outcome Measures; Pyrroles	2021

Other Studies

88 other study(ies) available for pyrroles and pexidartinib

Article	Year
Increased KIT inhibition enhances therapeutic efficacy in gastrointestinal stromal tumor. Clinical cancer research : an official journal of the American Association for Cancer Research, 2014, May-01, Volume: 20, Issue:9 Topics: Aminopyridines; Animals; Antineoplastic Agents; Benzamides; Biopsy; Cell Survival; Disease Models, Animal; Drug Evaluation, Preclinical; Gastrointestinal Stromal Tumors; Humans; Imatinib Mesylate; Inhibitory Concentration 50; Mice, Knockout; Molecular Targeted Therapy; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Pyrimidines; Pyrroles; Receptor, Macrophage Colony-Stimulating Factor; Tumor Burden	2014
Sustained inhibition of receptor tyrosine kinases and macrophage depletion by PLX3397 and rapamycin as a potential new approach for the treatment of MPNSTs. Clinical cancer research : an official journal of the American Association for Cancer Research, 2014, Jun-15, Volume: 20, Issue:12 Topics: Aminopyridines; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzamides; Blotting, Western; Cell Proliferation; Humans; Imatinib Mesylate; Macrophages; Mice; Mice, Inbred ICR; Mice, SCID; Neurilemmoma; Piperazines; Proto-Oncogene Proteins c-kit; Pyrimidines; Pyrroles; Receptor, Platelet-Derived Growth Factor beta; Sirolimus; Tumor Cells, Cultured; Xenograft Model Antitumor Assays	2014
Inhibition of c-Kit by tyrosine kinase inhibitors. Haematologica, 2015, Volume: 100, Issue:3 Topics: Aminopyridines; Antineoplastic Agents; Benzothiazoles; Biomarkers; Bone Marrow; Cell Line, Tumor; Clinical Trials as Topic; Dasatinib; fms-Like Tyrosine Kinase 3; Gene Expression; Hair; Hematopoietic Stem Cells; Humans; Indazoles; Leukemia, Myeloid, Acute; Niacinamide; Phenylurea Compounds; Pigmentation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Pyrimidines; Pyrroles; Sorafenib; Sulfonamides; Thiazoles	2015
Characterizing and Overriding the Structural Mechanism of the Quizartinib-Resistant FLT3 "Gatekeeper" F691L Mutation with PLX3397. Cancer discovery, 2015, Volume: 5, Issue:6 Topics: Aminopyridines; Animals; Antineoplastic Agents; Benzothiazoles; Cell Line, Tumor; Drug Resistance, Neoplasm; Enzyme Activation; fms-Like Tyrosine Kinase 3; Heterografts; Humans; Leukemia, Myeloid, Acute; Mice; Models, Molecular; Molecular Conformation; Mutation; Phenylurea Compounds; Protein Binding; Protein Interaction Domains and Motifs; Protein Kinase Inhibitors; Pyrroles; Recurrence; Structure-Activity Relationship	2015
Therapeutic Peptide Vaccine-Induced CD8 T Cells Strongly Modulate Intratumoral Macrophages Required for Tumor Regression. Cancer immunology research, 2015, Volume: 3, Issue:9 Topics: Aminopyridines; Animals; Cancer Vaccines; CD8-Positive T-Lymphocytes; Cell Movement; Chemokines; Disease Models, Animal; Female; Lymphocytes, Tumor-Infiltrating; Macrophages; Mice, Inbred C57BL; Myeloid Cells; Ovarian Neoplasms; Protein-Tyrosine Kinases; Pyrroles; Vaccines, Subunit	2015
Inhibition of colony stimulating factor-1 receptor improves antitumor efficacy of BRAF inhibition. BMC cancer, 2015, May-05, Volume: 15 Topics: Aminopyridines; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Drug Screening Assays, Antitumor; Drug Synergism; Indoles; Lymphocyte Activation; Macrophages; Melanoma, Experimental; Mice, Inbred C57BL; Mice, Inbred NOD; Mice, SCID; Neoplasm Transplantation; Proto-Oncogene Proteins B-raf; Pyrroles; Receptor, Macrophage Colony-Stimulating Factor; Sulfonamides; T-Lymphocytes; Vemurafenib	2015
Targeting cells of the myeloid lineage attenuates pain and disease progression in a prostate model of bone cancer. Pain, 2015, Volume: 156, Issue:9 Topics: Aminopyridines; Analgesics; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Bone and Bones; Bone Neoplasms; Cell Line, Tumor; Disease Models, Animal; Disease Progression; Dogs; Formaldehyde; Male; Mice; Mice, Nude; Neoplasm Transplantation; Pain; Pain Measurement; Prostatic Neoplasms; Protein Kinases; Pyrroles; Rats; Rats, Sprague-Dawley	2015
Elimination of Microglia Improves Functional Outcomes Following Extensive Neuronal Loss in the Hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015, Jul-08, Volume: 35, Issue:27 Topics: Aminopyridines; Animals; Behavioral Symptoms; Blood-Brain Barrier; Brain Injuries; Cognition Disorders; Dendritic Spines; Disease Models, Animal; Doxycycline; Female; Hippocampus; Male; Maze Learning; Mice; Mice, Transgenic; Microglia; Neurons; Phosphopyruvate Hydratase; Pyrroles; Recovery of Function; Synaptophysin	2015
Colony-Stimulating Factor 1 Receptor Antagonists Sensitize Human Immunodeficiency Virus Type 1-Infected Macrophages to TRAIL-Mediated Killing. Journal of virology, 2016, 07-15, Volume: 90, Issue:14 Topics: Aminopyridines; CD4-Positive T-Lymphocytes; Cells, Cultured; HIV Infections; HIV-1; Humans; Macrophage Colony-Stimulating Factor; Macrophages; Pyrroles; Receptor, Macrophage Colony-Stimulating Factor; TNF-Related Apoptosis-Inducing Ligand; Virus Latency; Virus Replication	2016
Distinct effects of inflammation on preconditioning and regeneration of the adult zebrafish heart. Open biology, 2016, Volume: 6, Issue:7 Topics: Aminopyridines; Animals; Anti-Inflammatory Agents; Cell Cycle; Cell Proliferation; Cryopreservation; Disease Models, Animal; Heart; Inflammation; Ischemic Preconditioning, Myocardial; Leukocytes; Myocardial Infarction; Myocytes, Cardiac; Pyrroles; Regeneration; Thoracotomy; Zebrafish	2016
Colony-stimulating factor 1 receptor blockade prevents fractionated whole-brain irradiation-induced memory deficits. Journal of neuroinflammation, 2016, 08-30, Volume: 13, Issue:1 Topics: Aminopyridines; Animals; Brain; Male; Memory Disorders; Mice; Mice, Inbred C57BL; Mice, Transgenic; Pyrroles; Radiation Effects; Receptor, Macrophage Colony-Stimulating Factor	2016
Colony stimulating factor 1 receptor inhibition eliminates microglia and attenuates brain injury after intracerebral hemorrhage. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2017, Volume: 37, Issue:7 Topics: Aminopyridines; Animals; Brain; Brain Edema; Cerebral Hemorrhage; Cytokines; Disease Models, Animal; Humans; Mice; Mice, Inbred C57BL; Microglia; Neuroimaging; Pyrroles; Receptor, Macrophage Colony-Stimulating Factor; Species Specificity	2017
Heterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3D organ imaging. Nature communications, 2017, 02-08, Volume: 8 Topics: Aminopyridines; Animals; Antineoplastic Agents; Carcinoma, Lewis Lung; Cell Line, Tumor; Female; Humans; Imaging, Three-Dimensional; Lung; Lung Neoplasms; Macrophage Colony-Stimulating Factor; Macrophages; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Microscopy, Fluorescence; Nanoparticles; Perfusion; Pyrroles; RAW 264.7 Cells; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Signal Transduction; Tomography, X-Ray Computed; Treatment Outcome; Tumor Burden; Tumor Microenvironment; Xenograft Model Antitumor Assays	2017
Depletion of microglia exacerbates postischemic inflammation and brain injury. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2017, Volume: 37, Issue:6 Topics: Aminopyridines; Animals; Brain Ischemia; Cells, Cultured; Disease Models, Animal; Inflammation Mediators; Magnetic Resonance Imaging; Male; Mice, Inbred C57BL; Microglia; Neurons; Primary Cell Culture; Proto-Oncogene Proteins c-kit; Pyrroles; Reactive Oxygen Species; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor	2017
Depletion of Tumor-Associated Macrophages with a CSF-1R Kinase Inhibitor Enhances Antitumor Immunity and Survival Induced by DC Immunotherapy. Cancer immunology research, 2017, Volume: 5, Issue:7 Topics: Aminopyridines; Animals; Antigens, Neoplasm; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Dendritic Cells; Disease Models, Animal; Humans; Immunotherapy, Adoptive; Lung Neoplasms; Macrophages; Mesothelioma; Mesothelioma, Malignant; Neoplasm Invasiveness; Programmed Cell Death 1 Receptor; Protein Kinase Inhibitors; Pyrroles; Receptor, Macrophage Colony-Stimulating Factor	2017
Inhibition of colony-stimulating factor 1 receptor early in disease ameliorates motor deficits in SCA1 mice. Journal of neuroinflammation, 2017, 05-25, Volume: 14, Issue:1 Topics: Aminopyridines; Animals; Ataxin-1; Calcium-Binding Proteins; Cerebellum; Disks Large Homolog 4 Protein; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Macrophage Colony-Stimulating Factor; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microfilament Proteins; Motor Activity; Motor Disorders; Mutation; Neuroglia; Postural Balance; Pyrroles; Spinocerebellar Ataxias; Tumor Necrosis Factor-alpha; Vesicular Glutamate Transport Protein 2	2017
Colony-Stimulating Factor 1 Receptor Blockade Inhibits Tumor Growth by Altering the Polarization of Tumor-Associated Macrophages in Hepatocellular Carcinoma. Molecular cancer therapeutics, 2017, Volume: 16, Issue:8 Topics: Aminopyridines; Animals; Biomarkers, Tumor; Bone Marrow Cells; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Polarity; Cell Proliferation; Humans; Liver Neoplasms; Macrophage Colony-Stimulating Factor; Macrophages; Male; Mice, Inbred BALB C; Mice, Inbred C57BL; Models, Biological; Monocytes; Phenotype; Pyrroles; Receptor, Macrophage Colony-Stimulating Factor; Tumor Microenvironment	2017
Inhibition of colony stimulating factor-1 receptor abrogates microenvironment-mediated therapeutic resistance in gliomas. Oncogene, 2017, 10-26, Volume: 36, Issue:43 Topics: Aminopyridines; Animals; Becaplermin; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Drug Resistance, Neoplasm; Glioma; Humans; Mice; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-sis; Pyrroles; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Tumor Microenvironment	2017
Depletion of microglia augments the dopaminergic neurotoxicity of MPTP. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2018, Volume: 32, Issue:6 Topics: Aminopyridines; Animals; Dopaminergic Neurons; Inflammation Mediators; Leukocytes; Male; Mice; Mice, Knockout; Microglia; MPTP Poisoning; Pyrroles; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor	2018
Microglia-mediated recovery from ALS-relevant motor neuron degeneration in a mouse model of TDP-43 proteinopathy. Nature neuroscience, 2018, Volume: 21, Issue:3 Topics: Aminopyridines; Amyotrophic Lateral Sclerosis; Animals; Gene Expression Profiling; Gliosis; Humans; Inflammation; Mice; Mice, Transgenic; Motor Neurons; Muscle, Skeletal; Mutation; Myeloid Cells; Pyrroles; Recovery of Function; Spinal Cord; Superoxide Dismutase-1; TDP-43 Proteinopathies	2018
Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer's disease. Molecular neurodegeneration, 2018, 03-01, Volume: 13, Issue:1 Topics: Alzheimer Disease; Aminopyridines; Amyloidogenic Proteins; Animals; Brain; Disease Models, Animal; Mice; Mice, Transgenic; Microglia; Neurons; Plaque, Amyloid; Pyrroles; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor	2018
Macrophages impede CD8 T cells from reaching tumor cells and limit the efficacy of anti-PD-1 treatment. Proceedings of the National Academy of Sciences of the United States of America, 2018, 04-24, Volume: 115, Issue:17 Topics: Aminopyridines; Animals; Carcinoma, Squamous Cell; CD8-Positive T-Lymphocytes; Follow-Up Studies; Macrophages; Mice; Programmed Cell Death 1 Receptor; Pyrroles; Receptor, Macrophage Colony-Stimulating Factor; Retrospective Studies; Xenograft Model Antitumor Assays	2018
Complete response to CSF1R inhibitor in a translocation variant of teno-synovial giant cell tumor without genomic alteration of the CSF1 gene. Annals of oncology : official journal of the European Society for Medical Oncology, 2018, 06-01, Volume: 29, Issue:6 Topics: Aminopyridines; Female; Giant Cell Tumors; Humans; Macrophage Colony-Stimulating Factor; Middle Aged; Prognosis; Pyrroles; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Remission Induction; Synovial Membrane; Translocation, Genetic	2018
Compensation between CSF1R+ macrophages and Foxp3+ Treg cells drives resistance to tumor immunotherapy. JCI insight, 2018, 06-07, Volume: 3, Issue:11 Topics: Aminopyridines; Animals; Cell Line, Tumor; Class I Phosphatidylinositol 3-Kinases; Diphtheria Toxin; Disease Models, Animal; Drug Resistance, Neoplasm; Female; Forkhead Transcription Factors; Gene Knockout Techniques; Humans; Lymphocyte Depletion; Macrophages; Male; Mice; Mice, Transgenic; Neoplasms; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Primary Cell Culture; Purines; Pyrroles; Quinazolinones; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; T-Lymphocytes, Regulatory; Tumor Microenvironment	2018
Microglia increases the proliferation of retinal precursor cells during postnatal development. Molecular vision, 2018, Volume: 24 Topics: Aminopyridines; Animals; Animals, Newborn; Bromodeoxyuridine; Calbindins; Calcium-Binding Proteins; Cell Communication; Cell Proliferation; Gene Expression Regulation, Developmental; Granulins; Injections, Intraperitoneal; Intercellular Signaling Peptides and Proteins; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Microfilament Proteins; Microglia; Nestin; Organogenesis; PAX6 Transcription Factor; Progranulins; Pyrroles; Retina; Rhodopsin; Stem Cells	2018
A limited capacity for microglial repopulation in the adult brain. Glia, 2018, Volume: 66, Issue:11 Topics: Aminopyridines; Animals; Brain; Calcium-Binding Proteins; CX3C Chemokine Receptor 1; Cytokines; Dose-Response Relationship, Drug; Gene Expression Profiling; Gene Ontology; Glial Fibrillary Acidic Protein; Luminescent Proteins; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microfilament Proteins; Microglia; Pyrroles; Receptor, Platelet-Derived Growth Factor alpha; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Signal Transduction	2018
Microglia mediate non-cell-autonomous cell death of retinal ganglion cells. Glia, 2018, Volume: 66, Issue:11 Topics: Aminopyridines; Animals; Animals, Newborn; Calcium-Binding Proteins; Cell Death; Cells, Cultured; Cytokines; Excitatory Amino Acid Agonists; Gene Expression Regulation; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microfilament Proteins; Microglia; N-Methylaspartate; Nerve Degeneration; Optic Nerve Injuries; Organic Chemicals; Pyrroles; Retinal Ganglion Cells; Signal Transduction; Transcription Factor Brn-3A; Tumor Necrosis Factor-alpha	2018
Inhibition of TAMs improves the response to docetaxel in castration-resistant prostate cancer. Endocrine-related cancer, 2019, 01-01, Volume: 26, Issue:1 Topics: Aminopyridines; Animals; Antineoplastic Agents; Cell Line; Cytokines; Docetaxel; Humans; Macrophages; Male; Mice; Prostatic Neoplasms, Castration-Resistant; Pyrroles; Receptor, Macrophage Colony-Stimulating Factor	2019
Partial reduction of microglia does not affect tau pathology in aged mice. Journal of neuroinflammation, 2018, Nov-09, Volume: 15, Issue:1 Topics: Aging; Aminopyridines; Animals; Blood Vessels; Calcium-Binding Proteins; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cytokines; Disease Models, Animal; Gene Expression Regulation; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microfilament Proteins; Microglia; Mutation; Pyrroles; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; RNA, Messenger; tau Proteins; Tauopathies	2018
Modulating the Tumor Microenvironment via Oncolytic Viruses and CSF-1R Inhibition Synergistically Enhances Anti-PD-1 Immunotherapy. Molecular therapy : the journal of the American Society of Gene Therapy, 2019, 01-02, Volume: 27, Issue:1 Topics: Aminopyridines; Animals; B7-H1 Antigen; CD8-Positive T-Lymphocytes; Colonic Neoplasms; Female; Flow Cytometry; Humans; Immunotherapy; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Oncolytic Viruses; Programmed Cell Death 1 Receptor; Pyrroles; Receptor, Macrophage Colony-Stimulating Factor; Tumor Microenvironment	2019
Targeting microglia attenuates neuroinflammation-related neural damage in mice carrying human PLP1 mutations. Glia, 2019, Volume: 67, Issue:2 Topics: Aminopyridines; Animals; Anti-Inflammatory Agents; Central Nervous System Diseases; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Flow Cytometry; Humans; Inflammation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Microscopy, Electron, Transmission; Mutation; Myelin Proteolipid Protein; Neurons; Pyrroles; T-Lymphocytes; Tomography, Optical Coherence	2019
Long-term characterization of activated microglia/macrophages facilitating the development of experimental brain metastasis through intravital microscopic imaging. Journal of neuroinflammation, 2019, Jan-07, Volume: 16, Issue:1 Topics: Aminopyridines; Animals; Brain; Brain Neoplasms; Cell Line, Tumor; CX3C Chemokine Receptor 1; Disease Models, Animal; Functional Laterality; Gene Expression Regulation, Neoplastic; Green Fluorescent Proteins; Intravital Microscopy; Macrophages; Matrix Metalloproteinase 3; Melanoma; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Pyrroles; Time Factors; Zonula Occludens-1 Protein	2019
Effect of the CSF1R inhibitor PLX3397 on remyelination of corpus callosum in a cuprizone-induced demyelination mouse model. Journal of cellular biochemistry, 2019, Volume: 120, Issue:6 Topics: Aminopyridines; Animals; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gene Expression Regulation; Indoles; Macrophage Colony-Stimulating Factor; Male; Mice, Inbred C57BL; Microglia; Microscopy, Electron, Transmission; Multiple Sclerosis; Myelin Sheath; Pyrroles; Real-Time Polymerase Chain Reaction; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Rotarod Performance Test	2019
Inducing cancer indolence by targeting mitochondrial Complex I is potentiated by blocking macrophage-mediated adaptive responses. Nature communications, 2019, 02-22, Volume: 10, Issue:1 Topics: Adenoma, Oxyphilic; Aminopyridines; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Drosophila; Electron Transport Complex I; Female; Gene Knockout Techniques; HCT116 Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Macrophages; Metformin; Mice; Mice, Knockout; Mice, Nude; NADH Dehydrogenase; Neovascularization, Pathologic; Pyrroles; Xenograft Model Antitumor Assays	2019
Surface Modification of Polymeric Nanoparticles with M2pep Peptide for Drug Delivery to Tumor-Associated Macrophages. Pharmaceutical research, 2019, Mar-11, Volume: 36, Issue:4 Topics: Aminopyridines; Animals; Cell Line; Cell Line, Tumor; Drug Carriers; Drug Delivery Systems; Humans; Macrophages; Male; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Nanoparticles; Peptides; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Pyrroles; RAW 264.7 Cells	2019
Disruption of tumour-associated macrophage trafficking by the osteopontin-induced colony-stimulating factor-1 signalling sensitises hepatocellular carcinoma to anti-PD-L1 blockade. Gut, 2019, Volume: 68, Issue:9 Topics: Aminopyridines; Animals; Antineoplastic Combined Chemotherapy Protocols; B7-H1 Antigen; Biomarkers, Tumor; Carcinoma, Hepatocellular; Chemotaxis; Cytokines; Gene Deletion; Humans; Liver Neoplasms; Lymphocytes, Tumor-Infiltrating; Macrophage Colony-Stimulating Factor; Macrophages; Male; Mice, Knockout; Molecular Targeted Therapy; Osteopontin; Prognosis; Pyrroles; Tumor Cells, Cultured; Tumor Escape; Tumor Microenvironment	2019
The CSF1 receptor inhibitor pexidartinib (PLX3397) reduces tissue macrophage levels without affecting glucose homeostasis in mice. International journal of obesity (2005), 2020, Volume: 44, Issue:1 Topics: Adipose Tissue; Aminopyridines; Animals; Diet, High-Fat; Glucose; Homeostasis; Insulin Resistance; Macrophages; Mice; Obesity; Pyrroles; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor	2020
Concentration-dependent effects of CSF1R inhibitors on oligodendrocyte progenitor cells ex vivo and in vivo. Experimental neurology, 2019, Volume: 318 Topics: Aminopyridines; Animals; Brain; Mice; Microglia; Oligodendrocyte Precursor Cells; Organic Chemicals; Pyrroles; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor	2019
Colony-stimulating factor 1 receptor inhibition prevents against lipopolysaccharide -induced osteoporosis by inhibiting osteoclast formation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019, Volume: 115 Topics: Aminopyridines; Animals; Biomechanical Phenomena; Bone Density; Bone Resorption; Cancellous Bone; Disease Models, Animal; Lipopolysaccharides; Male; Osteoclasts; Osteoporosis; Pyrroles; Rats, Sprague-Dawley; Receptor, Macrophage Colony-Stimulating Factor; Tibia	2019
Chronic inflammation, cognitive impairment, and distal brain region alteration following intracerebral hemorrhage. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019, Volume: 33, Issue:8 Topics: Aminopyridines; Animals; Brain; Cerebral Hemorrhage; Cognition; Cognitive Dysfunction; Disease Models, Animal; Fingolimod Hydrochloride; Flow Cytometry; Hippocampus; Inflammation; Male; Mice; Mice, Inbred C57BL; Microglia; Neuroimaging; Neuronal Plasticity; Pyrroles; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor	2019
[Pexidartinib inhibits the aggregation of monocytes into tumor microenvironment and reduces the number of M2 tumor-associated macrophages]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 2019, Volume: 35, Issue:4 Topics: Aminopyridines; Animals; Cell Line, Tumor; Colonic Neoplasms; Flow Cytometry; Leukocytes, Mononuclear; Macrophages; Mice; Monocytes; Pyrroles; Tumor Microenvironment	2019
IL-33-mediated mast cell activation promotes gastric cancer through macrophage mobilization. Nature communications, 2019, 06-21, Volume: 10, Issue:1 Topics: Aminopyridines; Animals; Cell Degranulation; Cromolyn Sodium; Disease Models, Animal; Epithelium; Female; Gastric Mucosa; Humans; Interleukin-1 Receptor-Like 1 Protein; Interleukin-33; Macrophages; Male; Mast Cells; Mice; Mice, Transgenic; Pyrroles; Signal Transduction; Stomach Neoplasms; Tissue Array Analysis; Tumor Microenvironment	2019
Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model. The Journal of experimental medicine, 2019, 11-04, Volume: 216, Issue:11 Topics: Alzheimer Disease; Aminopyridines; Animals; Apolipoproteins E; Brain; Dietary Supplements; Disease Models, Animal; Humans; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Microglia; Neurodegenerative Diseases; Pyrroles; tau Proteins; Tauopathies	2019
Colony-Stimulating Factor 1 Receptor (CSF1R) Activates AKT/mTOR Signaling and Promotes T-Cell Lymphoma Viability. Clinical cancer research : an official journal of the American Association for Cancer Research, 2020, 02-01, Volume: 26, Issue:3 Topics: Aminopyridines; Animals; Cell Line, Tumor; Gene Expression Profiling; Humans; Lymphoma, T-Cell, Peripheral; Macrophage Colony-Stimulating Factor; Macrophages; Mice; Mice, Inbred NOD; Mice, SCID; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrroles; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Signal Transduction; TOR Serine-Threonine Kinases; Tumor Microenvironment; Xenograft Model Antitumor Assays	2020
MicroRNA-148b-colony-stimulating factor-1 signaling-induced tumor-associated macrophage infiltration promotes hepatocellular carcinoma metastasis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019, Volume: 120 Topics: Aminopyridines; Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Proliferation; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Macrophage Colony-Stimulating Factor; Macrophages; Male; Mice; Mice, Nude; MicroRNAs; Neoplasm Metastasis; Neoplasms, Experimental; Pyrroles; Signal Transduction	2019
PLX3397 inhibits the accumulation of intra-tumoral macrophages and improves bromodomain and extra-terminal inhibitor efficacy in melanoma. Pigment cell & melanoma research, 2020, Volume: 33, Issue:2 Topics: Aminopyridines; Animals; Cell Line, Tumor; Cell Proliferation; Macrophages; Male; Melanoma; Mice, Inbred C57BL; Proteins; Proto-Oncogene Proteins B-raf; Pyrroles; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Skin Neoplasms; Treatment Outcome	2020
Activating mutations in CSF1R and additional receptor tyrosine kinases in histiocytic neoplasms. Nature medicine, 2019, Volume: 25, Issue:12 Topics: Adolescent; Adult; Aminopyridines; Anaplastic Lymphoma Kinase; Benzothiazoles; Child; Child, Preschool; Exome Sequencing; Female; Genome, Human; Hematologic Neoplasms; Histiocytosis; Humans; Infant; Male; Mutation; Picolinic Acids; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-ret; Pyrazoles; Pyridines; Pyrroles; Receptor Protein-Tyrosine Kinases; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Twins, Monozygotic; Young Adult	2019
Microglial depletion prevents extracellular matrix changes and striatal volume reduction in a model of Huntington's disease. Brain : a journal of neurology, 2020, 01-01, Volume: 143, Issue:1 Topics: Aminopyridines; Animals; Astrocytes; Chondroitin Sulfate Proteoglycans; Cytokines; Disease Models, Animal; Down-Regulation; Extracellular Matrix; Hand Strength; Humans; Huntingtin Protein; Huntington Disease; Inflammation; Mice; Mice, Transgenic; Microglia; Neostriatum; Neurites; Pyrroles; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Recognition, Psychology; RNA, Messenger; Synapses; Transcriptome	2020
Deciphering the molecular mechanism of FLT3 resistance mutations. The FEBS journal, 2020, Volume: 287, Issue:15 Topics: Aminopyridines; Benzothiazoles; Drug Resistance, Neoplasm; fms-Like Tyrosine Kinase 3; Humans; Mutation; Neoplasms; Phenylurea Compounds; Protein Conformation; Protein Kinase Inhibitors; Pyrroles	2020
Microglial activation increases cocaine self-administration following adolescent nicotine exposure. Nature communications, 2020, 01-16, Volume: 11, Issue:1 Topics: Aminopyridines; Animals; Chemokine CX3CL1; Cocaine; Disease Models, Animal; Drug-Seeking Behavior; Electronic Nicotine Delivery Systems; Female; Gene Expression Regulation; Male; Microglia; Minocycline; Nicotine; Phenotype; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Reinforcement, Psychology; Reward; Self Administration; Synaptophysin	2020
Microglial depletion and repopulation in brain slice culture normalizes sensitized proinflammatory signaling. Journal of neuroinflammation, 2020, Jan-18, Volume: 17, Issue:1 Topics: Aminopyridines; Animals; Ethanol; Hippocampus; Inflammation; Microglia; Neural Stem Cells; Organ Culture Techniques; Pyrroles; Rats; Signal Transduction; Toll-Like Receptors	2020
Age-related changes to macrophages are detrimental to fracture healing in mice. Aging cell, 2020, Volume: 19, Issue:3 Topics: Age Factors; Aminopyridines; Animals; Bony Callus; Cellular Senescence; Fracture Healing; Fractures, Bone; Inflammation; Macrophages; Mice; Mice, Inbred C57BL; Models, Animal; Pyrroles; RNA-Seq; Tibia; Transcriptome	2020
PLX3397 treatment inhibits constitutive CSF1R-induced oncogenic ERK signaling, reduces tumor growth, and metastatic burden in osteosarcoma. Bone, 2020, Volume: 136 Topics: Aminopyridines; Animals; Carcinogenesis; Macrophage Colony-Stimulating Factor; Mice; Osteosarcoma; Pyrroles; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor	2020
Antidepressive properties of macrophage-colony stimulating factor in a mouse model of depression induced by chronic unpredictable stress. Neuropharmacology, 2020, 08-01, Volume: 172 Topics: Aminopyridines; Animals; Antidepressive Agents; Depression; Dose-Response Relationship, Drug; Hippocampus; Macrophage Activation; Macrophage Colony-Stimulating Factor; Male; Mice; Mice, Inbred C57BL; Microglia; Minocycline; Pyrroles; Stress, Psychological	2020
Development of UPLC-MS/MS method for studying the pharmacokinetic interactions of pexidartinib with antifungal drugs in rats. Journal of pharmaceutical and biomedical analysis, 2020, Sep-05, Volume: 188 Topics: Adult; Aminopyridines; Animals; Antifungal Agents; Chromatography, High Pressure Liquid; Chromatography, Liquid; Humans; Pharmaceutical Preparations; Pyrroles; Rats; Reproducibility of Results; Tandem Mass Spectrometry	2020
ENLIVEN study: Pexidartinib for tenosynovial giant cell tumor (TGCT). Future oncology (London, England), 2020, Volume: 16, Issue:25 Topics: Aminopyridines; Giant Cell Tumor of Tendon Sheath; Humans; Protein Kinase Inhibitors; Pyrroles; Synovitis, Pigmented Villonodular	2020
Inhibition of Colony-Stimulating Factor 1 Receptor by PLX3397 Prevents Amyloid Beta Pathology and Rescues Dopaminergic Signaling in Aging 5xFAD Mice. International journal of molecular sciences, 2020, Aug-03, Volume: 21, Issue:15 Topics: Aging; Alzheimer Disease; Aminopyridines; Amyloid; Amyloid beta-Peptides; Animals; Brain; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Hippocampus; Humans; Macrophage Colony-Stimulating Factor; Mice; Mice, Transgenic; Pyrroles; Receptors, Colony-Stimulating Factor; Signal Transduction	2020
The effect of microglial ablation and mesenchymal stem cell transplantation on a cuprizone-induced demyelination model. Journal of cellular physiology, 2021, Volume: 236, Issue:5 Topics: Aminopyridines; Animals; Behavior, Animal; Biomarkers; Calcium-Binding Proteins; Chemokine CX3CL1; Corpus Callosum; Cuprizone; CX3C Chemokine Receptor 1; Demyelinating Diseases; Disease Models, Animal; Glial Fibrillary Acidic Protein; Injections, Intraventricular; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice, Inbred C57BL; Microfilament Proteins; Microglia; Myelin Sheath; Pyrroles	2021
Rescuing Over-activated Microglia Restores Cognitive Performance in Juvenile Animals of the Dp(16) Mouse Model of Down Syndrome. Neuron, 2020, 12-09, Volume: 108, Issue:5 Topics: Adult; Age Factors; Aminopyridines; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cognition; Disease Models, Animal; Down Syndrome; Female; Hippocampus; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Pyrroles	2020
Sex- and region-biased depletion of microglia/macrophages attenuates CLN1 disease in mice. Journal of neuroinflammation, 2020, Oct-28, Volume: 17, Issue:1 Topics: Aminopyridines; Animals; Brain; Disease Models, Animal; Female; Macrophages; Male; Mice; Microglia; Nerve Degeneration; Neuronal Ceroid-Lipofuscinoses; Neurons; Pyrroles; Retina; Sex Factors; T-Lymphocytes; Tomography, Optical Coherence	2020
Local Targeting of Lung-Tumor-Associated Macrophages with Pulmonary Delivery of a CSF-1R Inhibitor for the Treatment of Breast Cancer Lung Metastases. Molecular pharmaceutics, 2020, 12-07, Volume: 17, Issue:12 Topics: Administration, Inhalation; Administration, Intravenous; Aminopyridines; Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Line, Tumor; Disease Models, Animal; Drug Screening Assays, Antitumor; Drug Synergism; Female; Humans; Lung Neoplasms; Mice; Paclitaxel; Phosphorylation; Pyrroles; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Tumor Microenvironment; Tumor-Associated Macrophages	2020
Long-term outcomes of pexidartinib in tenosynovial giant cell tumors. Cancer, 2021, 03-15, Volume: 127, Issue:6 Topics: Adult; Aged; Aged, 80 and over; Aminopyridines; Female; Giant Cell Tumor of Tendon Sheath; Humans; Male; Middle Aged; Pyrroles; Young Adult	2021
Pexidartinib Long-Term Hepatic Safety Profile in Patients with Tenosynovial Giant Cell Tumors. The oncologist, 2021, Volume: 26, Issue:5 Topics: Aminopyridines; Chemical and Drug Induced Liver Injury; Giant Cell Tumor of Tendon Sheath; Humans; Liver; Pyrroles	2021
Microglia Elimination Increases Neural Circuit Connectivity and Activity in Adult Mouse Cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021, 02-10, Volume: 41, Issue:6 Topics: Aminopyridines; Animals; Female; Male; Mice; Microglia; Nerve Net; Photic Stimulation; Pyrroles; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Visual Cortex	2021
Microglial activation contributes to cognitive impairments in rotenone-induced mouse Parkinson's disease model. Journal of neuroinflammation, 2021, Jan-05, Volume: 18, Issue:1 Topics: Aminopyridines; Animals; Cognitive Dysfunction; Insecticides; Male; Mice; Mice, Inbred C57BL; Microglia; Minocycline; Parkinsonian Disorders; Pyrroles; Rotenone	2021
A qualitative evaluation of patient and healthcare provider knowledge, attitudes, and behavior for safety and use of pexidartinib. Journal of comparative effectiveness research, 2021, Volume: 10, Issue:3 Topics: Aminopyridines; Health Knowledge, Attitudes, Practice; Health Personnel; Humans; Pyrroles	2021
Microglia as target for anti-inflammatory approaches to prevent secondary brain injury after subarachnoid hemorrhage (SAH). Journal of neuroinflammation, 2021, Jan-30, Volume: 18, Issue:1 Topics: Aminopyridines; Animals; Anti-Inflammatory Agents; Brain Injuries; Ischemic Preconditioning; Mice; Mice, Inbred C57BL; Microglia; Pyrroles; Subarachnoid Hemorrhage	2021
Pexidartinib treatment in Alexander disease model mice reduces macrophage numbers and increases glial fibrillary acidic protein levels, yet has minimal impact on other disease phenotypes. Journal of neuroinflammation, 2021, Mar-08, Volume: 18, Issue:1 Topics: Alexander Disease; Aminopyridines; Animals; Disease Models, Animal; Glial Fibrillary Acidic Protein; Macrophages; Mice; Mice, Inbred C57BL; Phenotype; Pyrroles	2021
Brainstem local microglia induce whisker map plasticity in the thalamus after peripheral nerve injury. Cell reports, 2021, 03-09, Volume: 34, Issue:10 Topics: Aminopyridines; Animals; Brain Stem; Female; Hypersensitivity; Male; Mice; Mice, Inbred C57BL; Microglia; Neurons; Peripheral Nerve Injuries; Pyrroles; Thalamus; Ventral Thalamic Nuclei; Vibrissae	2021
The receptor of the colony-stimulating factor-1 (CSF-1R) is a novel prognostic factor and therapeutic target in follicular lymphoma. Leukemia, 2021, Volume: 35, Issue:9 Topics: Aminopyridines; Animals; Apoptosis; Biomarkers, Tumor; Cell Differentiation; Cell Proliferation; Gene Expression Regulation, Neoplastic; Humans; Lymphoma, Follicular; Macrophages; Mice; Monocytes; Phosphorylation; Pyrroles; Receptor, Macrophage Colony-Stimulating Factor; Tumor Cells, Cultured; Tumor Microenvironment; Xenograft Model Antitumor Assays	2021
Effect of CSF1R inhibitor on glial cells population and remyelination in the cuprizone model. Neuropeptides, 2021, Volume: 89 Topics: Aminopyridines; Animals; Cuprizone; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Neuroglia; Pyrroles; Receptor, Macrophage Colony-Stimulating Factor; Remyelination	2021
Partial depletion and repopulation of microglia have different effects in the acute MPTP mouse model of Parkinson's disease. Cell proliferation, 2021, Volume: 54, Issue:8 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Aminopyridines; Animals; Behavior, Animal; Cyclooxygenase 2; Cytokines; Disease Models, Animal; Dopaminergic Neurons; Inflammation Mediators; Male; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Microglia; MPTP Poisoning; Neuroprotective Agents; Pyrroles; Receptors, Immunologic	2021
A Phase I Study of the Combination of Pexidartinib and Sirolimus to Target Tumor-Associated Macrophages in Unresectable Sarcoma and Malignant Peripheral Nerve Sheath Tumors. Clinical cancer research : an official journal of the American Association for Cancer Research, 2021, 10-15, Volume: 27, Issue:20 Topics: Aminopyridines; Humans; Male; Middle Aged; Neurofibrosarcoma; Pyrroles; Sarcoma; Sirolimus; Tumor-Associated Macrophages	2021
Depletion of microglia mitigates cerebrovascular dysfunction in diet-induced obesity mice. American journal of physiology. Endocrinology and metabolism, 2021, 09-01, Volume: 321, Issue:3 Topics: Aminopyridines; Animals; Basilar Artery; Cerebrovascular Disorders; Encephalitis; Male; Mice, Inbred C57BL; Microglia; Obesity; Pyrroles	2021
Inhibition of CSF1R, a receptor involved in microglia viability, alters behavioral and molecular changes induced by cocaine. Scientific reports, 2021, 08-06, Volume: 11, Issue:1 Topics: Aminopyridines; Animals; Behavior, Animal; Brain; Chemokine CX3CL1; Cocaine; Cocaine-Related Disorders; Conditioning, Classical; Dopamine Uptake Inhibitors; Hippocampus; Inhibition, Psychological; Male; Mice; Microglia; Pyrroles; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor	2021
Microglia Depletion-Induced Remodeling of Extracellular Matrix and Excitatory Synapses in the Hippocampus of Adult Mice. Cells, 2021, 07-22, Volume: 10, Issue:8 Topics: Aminopyridines; Animals; Brevican; CA1 Region, Hippocampal; CX3C Chemokine Receptor 1; Electrical Synapses; Excitatory Postsynaptic Potentials; Extracellular Matrix; gamma-Aminobutyric Acid; Green Fluorescent Proteins; Luminescent Proteins; Male; Mice, Transgenic; Microglia; Nerve Net; Pyrroles; Red Fluorescent Protein; Vesicular Glutamate Transport Protein 1	2021
PLX3397, a CSF1 receptor inhibitor, limits allotransplantation-induced vascular remodelling. Cardiovascular research, 2022, 09-20, Volume: 118, Issue:12 Topics: Aminopyridines; Animals; Macrophage Colony-Stimulating Factor; Mice; Protein Kinase Inhibitors; Pyrroles; Receptor Protein-Tyrosine Kinases; Vascular Remodeling	2022
Exposure-response analysis of efficacy and safety for pexidartinib in patients with tenosynovial giant cell tumor. CPT: pharmacometrics & systems pharmacology, 2021, Volume: 10, Issue:11 Topics: Aminopyridines; Giant Cell Tumor of Tendon Sheath; Humans; Pyrroles; Response Evaluation Criteria in Solid Tumors	2021
Tenosynovial giant cell tumor-diffuse type, treated with a novel colony-stimulating factor inhibitor, pexidartinib: initial experience with MRI findings in three patients. Skeletal radiology, 2022, Volume: 51, Issue:5 Topics: Adult; Aminopyridines; Colony-Stimulating Factors; Giant Cell Tumor of Tendon Sheath; Humans; Magnetic Resonance Imaging; Pyrroles; Synovitis, Pigmented Villonodular	2022
Myosin 1f-mediated activation of microglia contributes to the photoreceptor degeneration in a mouse model of retinal detachment. Cell death & disease, 2021, 10-09, Volume: 12, Issue:10 Topics: Aminopyridines; Animals; Calcium-Binding Proteins; Cell Death; Cell Line; Disease Models, Animal; Gene Expression Profiling; Light; MAP Kinase Signaling System; Mice, Knockout; Microfilament Proteins; Microglia; Models, Biological; Myosin Type I; Myosins; Photoreceptor Cells, Vertebrate; Proto-Oncogene Proteins c-akt; Pyrroles; Retinal Degeneration; Retinal Detachment; Up-Regulation	2021
Results from Phase I Extension Study Assessing Pexidartinib Treatment in Six Cohorts with Solid Tumors including TGCT, and Abnormal CSF1 Transcripts in TGCT. Clinical cancer research : an official journal of the American Association for Cancer Research, 2022, 01-15, Volume: 28, Issue:2 Topics: Adult; Aminopyridines; Giant Cell Tumor of Tendon Sheath; Humans; Protein Kinase Inhibitors; Pyrroles	2022
Quantification of the janus kinase 1 inhibitor upadacitinib in human plasma by LC-MS/MS. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2022, Jan-01, Volume: 1188 Topics: Aminopyridines; Antirheumatic Agents; Arthritis, Rheumatoid; Chromatography, Liquid; Drug Monitoring; Heterocyclic Compounds, 3-Ring; Humans; Janus Kinase Inhibitors; Limit of Detection; Linear Models; Pyrroles; Reproducibility of Results; Tandem Mass Spectrometry	2022
Sustained, complete response to pexidartinib in a patient with CSF1R-mutated Erdheim-Chester disease. American journal of hematology, 2022, 03-01, Volume: 97, Issue:3 Topics: Aminopyridines; Cell Line; Erdheim-Chester Disease; Female; Humans; Mutation; Pyrroles; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor	2022
Eco-Friendly, Simple, Fast, and Sensitive UPLC-MS/MS Method for Determination of Pexidartinib in Plasma and Its Application to Metabolic Stability. Molecules (Basel, Switzerland), 2022, Jan-04, Volume: 27, Issue:1 Topics: Aminopyridines; Antineoplastic Agents, Immunological; Chromatography, High Pressure Liquid; Drug Monitoring; Drug Stability; Molecular Structure; Protein Kinase Inhibitors; Pyrroles; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry	2022
Microglial replacement in the aged brain restricts neuroinflammation following intracerebral hemorrhage. Cell death & disease, 2022, 01-10, Volume: 13, Issue:1 Topics: Aging; Aminopyridines; Animals; Blood-Brain Barrier; Brain; Brain Injuries; Cell Death; Cerebral Hemorrhage; Chemotaxis, Leukocyte; Disease Models, Animal; Mice; Microglia; Neuroinflammatory Diseases; Pyrroles; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor	2022
Effect of Mild and Moderate Hepatic Impairment (Defined by Child-Pugh Classification and National Cancer Institute Organ Dysfunction Working Group Criteria) on Pexidartinib Pharmacokinetics. Journal of clinical pharmacology, 2022, Volume: 62, Issue:8 Topics: Aminopyridines; Area Under Curve; Humans; Liver Diseases; Multiple Organ Failure; National Cancer Institute (U.S.); Neoplasms; Pyrroles; United States	2022
Early posttraumatic CSF1R inhibition via PLX3397 leads to time- and sex-dependent effects on inflammation and neuronal maintenance after traumatic brain injury in mice. Brain, behavior, and immunity, 2022, Volume: 106 Topics: Aminopyridines; Animals; Brain Injuries, Traumatic; Disease Models, Animal; Female; Inflammation; Macrophage Colony-Stimulating Factor; Male; Mice; Mice, Inbred C57BL; Microglia; Oxidoreductases; Pyrroles; Receptors, Colony-Stimulating Factor; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor	2022
CORR Insights®: Pexidartinib Provides Modest Pain Relief in Patients With Tenosynovial Giant Cell Tumor: Results From ENLIVEN. Clinical orthopaedics and related research, 2023, 01-01, Volume: 481, Issue:1 Topics: Aminopyridines; Giant Cell Tumor of Tendon Sheath; Humans; Pain; Pyrroles	2023