pyrroles and oxadiazoles

Topics: Administration, Oral; Animals; Antimony; Chemosterilants; Child; Cricetinae; Cysteine; Drug Evaluation; Drug Evaluation, Preclinical; Ethylenediamines; Haplorhini; Humans; Injections, Intramuscular; Mice; Nitro Compounds; Nitrofurans; Oxadiazoles; Propylamines; Pyrimidines; Pyrroles; Quinolines; Ribonucleosides; Schistosoma mansoni; Schistosomiasis; Schistosomicides; Thiazoles; Thioxanthenes; Trypsin Inhibitors; Vinyl Compounds

Topics: Acridines; Animals; Brain; Cytoplasm; Hydrazines; Iproniazid; Isoquinolines; Liver; Membranes; Mitochondria; Monoamine Oxidase Inhibitors; Oxadiazoles; Pargyline; Parkinson Disease; Pyridines; Pyrroles; Radiation Injuries; Rats; Tranylcypromine; Vitamin D

Topics: Animals; Cytochrome P-450 Enzyme System; Furans; Heterocyclic Compounds, 4 or More Rings; Humans; Imidazoles; Indoles; Isoxazoles; Models, Chemical; Molecular Structure; Oxadiazoles; Oxazoles; Pyrazoles; Pyrroles; Tetrazoles; Thiadiazoles; Thiazoles; Thiophenes; Triazoles; Xenobiotics

Topics: Antibodies, Monoclonal, Humanized; Biological Products; Cell Adhesion Molecules; Gastrointestinal Agents; Humans; Immunoglobulins; Indans; Inflammatory Bowel Diseases; Mucoproteins; Oligonucleotides; Oxadiazoles; Piperidines; Pyrimidines; Pyrroles; Tumor Necrosis Factor-alpha; Ustekinumab

Topics: B-Lymphocytes; Colitis, Ulcerative; Crohn Disease; Humans; Indans; Janus Kinase 1; Janus Kinase Inhibitors; Oligonucleotides; Oxadiazoles; Piperidines; Pyridines; Pyrimidines; Pyrroles; Receptors, Lysosphingolipid; Smad7 Protein; T-Lymphocytes; Triazoles

Topics: Anti-Inflammatory Agents, Non-Steroidal; Drug Discovery; Heterocyclic Compounds, 3-Ring; Humans; Indans; Inflammatory Bowel Diseases; Janus Kinase Inhibitors; Mesalamine; Oxadiazoles; Phosphodiesterase Inhibitors; Piperidines; Pyridines; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Receptors, Lysosphingolipid; Triazoles

Topics: Adolescent; Adult; Aged; Animals; Atorvastatin; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Demography; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Female; Fluorobenzenes; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Madin Darby Canine Kidney Cells; Male; Mesylates; Middle Aged; Oxadiazoles; Piperidines; Pyrimidines; Pyrroles; Reference Standards; Rosuvastatin Calcium; Simvastatin; Sulfonamides; Troleandomycin; Young Adult

Topics: Animals; Benzopyrans; Cromakalim; Cyclic GMP; Drug Interactions; Epithelium; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Nitroprusside; Oxadiazoles; Piperidines; Potassium Channels; Pyrroles; SRS-A; Trachea; Vasodilator Agents

Topics: Animals; Benzopyrans; Cromakalim; Guinea Pigs; In Vitro Techniques; Muscle, Smooth; Oxadiazoles; Piperidines; Potassium Channels; Pyrroles; Trachea; Vasodilator Agents

Topics: Acetylcholine; Aminophylline; Animals; Benzopyrans; Cromakalim; Electric Stimulation; Guinea Pigs; Hydrocortisone; Isoproterenol; Male; Muscle Contraction; Muscle, Smooth; Oxadiazoles; Piperidines; Potassium Channels; Pyrroles; Trachea

Topics: Administration, Oral; Animals; Antihypertensive Agents; Benzopyrans; Blood Pressure; Cromakalim; Dose-Response Relationship, Drug; Heart Rate; Injections, Intravenous; Male; Oxadiazoles; Piperidines; Potassium Channels; Pyrroles; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Rats, Inbred WKY; Species Specificity

Topics: Action Potentials; Animals; Antihypertensive Agents; Benzopyrans; Cromakalim; Depression, Chemical; Guinea Pigs; Heart Rate; Heart Ventricles; Male; Myocardial Contraction; Oxadiazoles; Piperidines; Potassium Channels; Pyrroles

Topics: Animals; Arachidonic Acid; Benzopyrans; Cromakalim; Dinoprost; Glyburide; Guinea Pigs; Indomethacin; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Oxadiazoles; Piperidines; Potassium Channels; Prostaglandin D2; Prostaglandin Endoperoxides, Synthetic; Prostaglandins; Pyrroles; Sulfonamides; Trachea

Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Benzopyrans; Cromakalim; Glyburide; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Oxadiazoles; Phentolamine; Piperidines; Portal Vein; Potassium Channels; Potassium Chloride; Pyrroles; Rats; Rats, Inbred Strains; Rubidium Radioisotopes

Topics: Animals; Benzopyrans; Calcium; Cromakalim; Dose-Response Relationship, Drug; In Vitro Techniques; Ion Channels; Isradipine; Oxadiazoles; Portal Vein; Potassium; Pyrroles; Rats; Rubidium Radioisotopes; Scorpion Venoms; Vasodilator Agents

Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arginine; Benzopyrans; Cromakalim; Epithelium; Guinea Pigs; Male; Methylene Blue; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Oxadiazoles; Piperidines; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Thromboxane A2; Trachea; Vasoactive Intestinal Peptide

Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Anesthesia; Animals; Benzopyrans; Coronary Circulation; Cromakalim; Dogs; Female; Hemodynamics; Male; Oxadiazoles; Piperidines; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Rats; Rats, Wistar; Thromboxane A2; Vasoconstrictor Agents; Vasodilator Agents

Topics: Adenosine Triphosphate; Animals; Benzopyrans; Blood Flow Velocity; Blood Pressure; Cardiac Output; Cardiovascular System; Carotid Arteries; Coronary Circulation; Cromakalim; Cyclic N-Oxides; Dipyridamole; Dogs; Dose-Response Relationship, Drug; Female; Femoral Artery; Glyburide; Heart Rate; Injections, Intravenous; Male; Mesenteric Arteries; Nitroglycerin; Oxadiazoles; Potassium Channels; Pyrroles; Renal Artery; Vascular Resistance; Vasodilator Agents

Topics: Animals; Aorta; Benzopyrans; Calcimycin; Cromakalim; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nifedipine; Oxadiazoles; Piperidines; Pyrroles; Rats; Rats, Wistar; Vasoconstriction; Vasodilator Agents

Topics: Action Potentials; Adenosine Triphosphate; Analysis of Variance; Animals; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Guinea Pigs; Hypoglycemic Agents; Muscle Relaxation; Muscle, Smooth, Vascular; Myocardial Contraction; Myocardium; Oxadiazoles; Papillary Muscles; Patch-Clamp Techniques; Piperidines; Potassium Channels; Pyrroles; Vasodilator Agents

Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Benzopyrans; Cromakalim; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Activation; Epithelium; Guinea Pigs; Histamine; Indomethacin; Leukotriene D4; Male; Melitten; Muscle Relaxation; Muscle, Smooth; Oxadiazoles; Phospholipases A; Phospholipases A2; Piperidines; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Thromboxane A2; Trachea

Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclase Inhibitors; Alkaloids; Animals; Carbazoles; Cattle; Cell Line; Cell Survival; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic N-Oxides; Dideoxyadenosine; Endothelium, Vascular; Enzyme Inhibitors; Free Radical Scavengers; Imidazoles; Indoles; Kinetics; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Penicillamine; Pulmonary Artery; Pyrroles; Quinoxalines; S-Nitroso-N-Acetylpenicillamine; Tumor Necrosis Factor-alpha

Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aminopyridines; Animals; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Indoles; Injections, Intraventricular; Male; Oxadiazoles; Piperazines; Pyridines; Pyrroles; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Self Administration; Serotonin Antagonists; Serotonin Receptor Agonists

Topics: Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Calcium; Cell Line; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Kidney; Methiothepin; Opossums; Oxadiazoles; Pertussis Toxin; Pindolol; Piperazines; Pyridines; Pyrroles; Radioligand Assay; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Virulence Factors, Bordetella

Topics: 5-Methoxytryptamine; Animals; Blood Pressure; Central Nervous System; Oxadiazoles; Pindolol; Piperazines; Pyridines; Pyrroles; Rats; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Sumatriptan; Sympathetic Nervous System

Topics: Animals; Corpus Striatum; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Male; Membranes; Oxadiazoles; Pyridines; Pyrroles; Radioligand Assay; Rats; Serotonin; Serotonin Receptor Agonists; Stimulation, Chemical; Sulfur Radioisotopes; Tryptamines

Topics: Adenine; Adenylyl Cyclase Inhibitors; Amidines; Animals; Arginine; Benzylamines; Carbazoles; Colforsin; Cyclic AMP; Dexamethasone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gastric Fundus; In Vitro Techniques; Indoles; Isoquinolines; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitroarginine; Oxadiazoles; Protein Kinase Inhibitors; Pyrroles; Quinoxalines; Sulfonamides; Swine; Thionucleotides; Vasoactive Intestinal Peptide

Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Autoreceptors; Benzamides; Biphenyl Compounds; Drug Synergism; Electric Stimulation; In Vitro Techniques; Male; Oxadiazoles; Piperazines; Protein Isoforms; Pyridines; Pyrroles; Raphe Nuclei; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Sumatriptan; Time Factors

Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Benzamides; Electrophysiology; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Indoles; Male; Oxadiazoles; Pindolol; Piperazines; Potassium; Pyridines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Ventral Tegmental Area

Topics: Animals; Benzamides; Brachial Plexus; Dose-Response Relationship, Drug; Eating; Fenfluramine; Infusions, Intravenous; Male; Oxadiazoles; Pyridines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists

Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamine; Amphetamines; Animals; Central Nervous System Stimulants; Conditioning, Operant; Dose-Response Relationship, Drug; Food; Male; Nucleus Accumbens; Oxadiazoles; Piperazines; Pyridines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Reinforcement Schedule; Self Administration; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists

Topics: Animals; Carbazoles; Electric Stimulation; Enzyme Inhibitors; Gastric Fundus; Gastrointestinal Agents; Hydrazines; In Vitro Techniques; Indoles; Male; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Nitric Oxide Donors; Nitroarginine; Nitrogen Oxides; Okadaic Acid; Oxadiazoles; Phosphodiesterase Inhibitors; Phosphoprotein Phosphatases; Purinones; Pyrroles; Quinoxalines; Rats; Rats, Wistar; Synaptic Transmission; Vasoactive Intestinal Peptide

Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acetaminophen; Analgesics, Non-Narcotic; Animals; Autoreceptors; Benzamides; Male; Mice; Oxadiazoles; Pyridines; Pyrroles; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Receptors, Serotonin, 5-HT1

Topics: Alkaloids; Amylases; Animals; Azepines; Benzoates; Benzylamines; Calcium; Calcium Channel Blockers; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Carbazoles; Chelating Agents; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Estrenes; Gallic Acid; Genotype; Guanylate Cyclase; Imidazoles; In Vitro Techniques; Indoles; Male; Mice; Mice, Knockout; Molsidomine; Muscarinic Agonists; Myosin-Light-Chain Kinase; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxadiazoles; Parotid Gland; Penicillamine; Phosphodiesterase Inhibitors; Pilocarpine; Protein Kinase Inhibitors; Pyrroles; Pyrrolidinones; Quinoxalines; Quinuclidines; Rats; Rats, Wistar; Sulfonamides; Thiophenes; Type C Phospholipases

Topics: Animals; Biphenyl Compounds; Decerebrate State; Male; Norepinephrine; Oxadiazoles; Piperazines; Piperidones; Pyridines; Pyrroles; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists; Spiro Compounds; Sumatriptan; Sympathomimetics; Tachycardia

Topics: Adenine; Adenylyl Cyclases; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Blotting, Western; Carbazoles; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; GTP-Binding Proteins; Guanylate Cyclase; Indoles; Male; Muscle Relaxation; Muscle, Smooth; Oxadiazoles; Procaterol; Pyrroles; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Receptors, Adrenergic, beta-1; Receptors, Adrenergic, beta-2; Receptors, Adrenergic, beta-3; Suramin; Xamoterol

Topics: Analysis of Variance; Animals; Benzamides; Biphenyl Compounds; Calcium Channel Blockers; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Membrane Potentials; Muscimol; Neural Inhibition; Neurons; omega-Agatoxin IVA; omega-Conotoxin GVIA; Oxadiazoles; Patch-Clamp Techniques; Pertussis Toxin; Phosphinic Acids; Piperazines; Presynaptic Terminals; Propanolamines; Pyridines; Pyrroles; Quinoxalines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1B; Septal Nuclei; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Synaptic Transmission

Topics: Animals; Baclofen; Benzamides; Biphenyl Compounds; Dopamine; GABA Agonists; gamma-Aminobutyric Acid; Male; Microdialysis; Neural Pathways; Neurons; Nucleus Accumbens; Oxadiazoles; Piperazines; Pyridines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1B; Serotonin Antagonists; Serotonin Receptor Agonists; Ventral Tegmental Area

Topics: Aged; Autoradiography; Binding, Competitive; Biphenyl Compounds; Brain; Dipeptides; Drug Interactions; Female; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Male; Middle Aged; Oxadiazoles; Piperazines; Piperidones; Postmortem Changes; Protein Binding; Pyridines; Pyrroles; Receptor, Serotonin, 5-HT1B; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spiro Compounds; Sulfur Isotopes

Topics: Analgesics, Opioid; Animals; Benzamides; Dose-Response Relationship, Drug; Male; Mice; Oxadiazoles; Pain Threshold; Piperazines; Pyridines; Pyrroles; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT1B; Serotonin Antagonists; Serotonin Receptor Agonists; Tramadol

Topics: Administration, Oral; Animals; Antineoplastic Agents; Biological Availability; Blood Proteins; Cell Proliferation; Drug Design; Endothelium, Vascular; Humans; Hydroxamic Acids; In Vitro Techniques; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Microsomes, Liver; Models, Molecular; Oxadiazoles; Protein Binding; Pyrroles; Receptor Protein-Tyrosine Kinases; Receptor, Fibroblast Growth Factor, Type 1; Receptors, Fibroblast Growth Factor; Structure-Activity Relationship; Triazines; Vascular Endothelial Growth Factor Receptor-2; Xenograft Model Antitumor Assays

Topics: Acetylcholine; Animals; Aorta; Biliverdine; Blotting, Western; Carbon Monoxide; Chromium; Densitometry; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Endothelium, Vascular; Femoral Artery; Guanylate Cyclase; Heme; Immunohistochemistry; Male; Mesoporphyrins; Muscle Contraction; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Organometallic Compounds; Oxadiazoles; Oxidative Stress; Protoporphyrins; Pyrazines; Pyrroles; Quinoxalines; Rats; Rats, Sprague-Dawley; Stress, Mechanical; Time Factors

Topics: Aggression; Animals; Behavior, Animal; Conditioning, Operant; Dose-Response Relationship, Drug; Male; Mice; Oxadiazoles; Piperazines; Pyridines; Pyrroles; Raphe Nuclei; Serotonin 5-HT1 Receptor Agonists; Serotonin Antagonists; Serotonin Receptor Agonists

Topics: Anti-Bacterial Agents; Antitubercular Agents; Benzoic Acid; Drug Design; Mycobacterium tuberculosis; Oxadiazoles; Pyrroles; Triazoles

Topics: Animals; Cell Line, Tumor; Cyclopropanes; Cytochrome P-450 Enzyme Inhibitors; Endothelial Cells; Humans; Lung Neoplasms; Mice; Mice, Nude; Oxadiazoles; Protein Kinase Inhibitors; Pyrroles; Structure-Activity Relationship; Triazines; Vascular Endothelial Growth Factor Receptor-2; Xenograft Model Antitumor Assays

Topics: Antimitotic Agents; Apoptosis; Binding Sites; Biomarkers; Cell Cycle; Cell Line, Tumor; Computer Simulation; Drug Screening Assays, Antitumor; Humans; Indenes; Indoles; Models, Chemical; Oxadiazoles; Pyrroles; Tubulin

Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Avoidance Learning; Azabicyclo Compounds; Behavior, Animal; Cell Line; Cognition Disorders; Dose-Response Relationship, Drug; Furans; Humans; Male; Mice; Nicotinic Agonists; Oocytes; Oxadiazoles; Pyridazines; Pyrroles; Rats; Receptors, Nicotinic; Xenopus laevis

Topics: Animals; Atorvastatin; Enzyme Inhibitors; Guanylate Cyclase; Heptanoic Acids; Mice; Nitric Oxide; Norepinephrine; Oxadiazoles; Polymerase Chain Reaction; Pyrroles; Quinoxalines; Receptors, Adrenergic, alpha-1; RNA, Messenger; Sepsis; Vasoconstrictor Agents

Topics: Animals; Antiprotozoal Agents; Cell Line; Eukaryota; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Molecular Structure; Oxadiazoles; Protozoan Infections; Pyrroles; Rats; Spectrometry, Mass, Electrospray Ionization; Spectroscopy, Fourier Transform Infrared; Structure-Activity Relationship; Triazoles

Topics: Alkaloids; Anti-Infective Agents; Antitubercular Agents; Bacteria; Bacterial Infections; Fungi; Halogenation; Humans; Microbial Sensitivity Tests; Mycoses; Oxadiazoles; Pyrroles

Topics: Animals; Antibiotics, Antitubercular; Antifungal Agents; Bacillus subtilis; Candida albicans; Chlorocebus aethiops; Dose-Response Relationship, Drug; Escherichia coli; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Oxadiazoles; Pyrroles; Staphylococcus aureus; Structure-Activity Relationship; Vero Cells

Topics: Administration, Oral; Anti-Inflammatory Agents; Colitis, Ulcerative; Crohn Disease; Humans; Immunologic Factors; Indans; Inflammatory Bowel Diseases; Oxadiazoles; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Quinolones; Randomized Controlled Trials as Topic; Treatment Outcome; Tumor Necrosis Factor-alpha

Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Animals; Antineoplastic Agents; Apoptosis; Drug Combinations; Drug Screening Assays, Antitumor; Drug Synergism; Gene Expression Regulation, Neoplastic; Humans; Lymphoma, Large B-Cell, Diffuse; Mice; NF-kappa B; Organ Specificity; Oxadiazoles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Piperidines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-myc; PTEN Phosphohydrolase; Pyrazoles; Pyrimidines; Pyrroles; Signal Transduction; Xenograft Model Antitumor Assays

Topics: Antineoplastic Agents; Apoptosis; Benzylamines; Caspase 3; Caspase 7; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; Forkhead Box Protein O1; G1 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Glycogen Synthase Kinase 3 beta; Heterocyclic Compounds, 3-Ring; Heterocyclic Compounds, 4 or More Rings; Humans; Imidazoles; Inhibitory Concentration 50; Mesothelioma; Oxadiazoles; Phosphorylation; Phosphorylcholine; Pleural Neoplasms; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrazoles; Pyridines; Pyrimidines; Pyrroles; Quinoxalines; Sulfonamides; Thiadiazoles; Thiophenes

Topics: Action Potentials; Adenine; Carbazoles; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Humans; Myofibroblasts; Nitric Oxide; Oxadiazoles; Potassium Channels, Voltage-Gated; Pyrroles; Quinoxalines; S-Nitroso-N-Acetylpenicillamine

Topics: Animals; Apamin; Barium Compounds; Calcium Chloride; Chlorides; Dose-Response Relationship, Drug; Endothelium, Vascular; Estradiol; Fulvestrant; Glyburide; In Vitro Techniques; Indomethacin; Isoquinolines; Kaempferols; Male; Morpholines; NG-Nitroarginine Methyl Ester; Oxadiazoles; Peptides; Potassium; Pulmonary Artery; Pyrroles; Quinoxalines; Rats; Sulfonamides; Tetraethylammonium; Vasodilation; Vasodilator Agents

Topics: Acetylation; Animals; Breast Neoplasms; Cell Cycle Proteins; Cell Line, Tumor; Cell Nucleus; Cyclin-Dependent Kinase 6; Female; Forkhead Box Protein O3; Gene Expression Regulation; Heterocyclic Compounds, 3-Ring; Humans; Mice; Mice, Nude; Nuclear Proteins; Oxadiazoles; Promoter Regions, Genetic; Protein Binding; Protein Domains; Protein Kinase Inhibitors; Protein Transport; Proto-Oncogene Proteins c-akt; Pyrimidines; Pyrroles; Sirtuins; Transcription Factors

Topics: Active Transport, Cell Nucleus; Adenine; Animals; Antineoplastic Agents; beta Catenin; Cell Differentiation; Cell Transdifferentiation; Dictyostelium; Dose-Response Relationship, Drug; Glycogen Synthase Kinase 3 beta; Hepatic Stellate Cells; Hexanones; Liver Cirrhosis; Mice; Oxadiazoles; Phosphorylation; Pyrimidines; Pyrroles; Quinoxalines; Signal Transduction

Topics: Antioxidants; Catalytic Domain; Cell Line; Cell Survival; Circular Dichroism; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Drug Design; Female; Fibroblasts; Humans; Inhibitory Concentration 50; Mannich Bases; Middle Aged; Molecular Docking Simulation; Molecular Structure; Oxadiazoles; Pyridazines; Pyrroles; Serum Albumin, Bovine; Structure-Activity Relationship

Topics: Analgesics; Animals; Dinoprostone; Gastric Mucosa; Male; Nociception; Nociceptive Pain; Oxadiazoles; Pain Measurement; Peroxidase; Pyridazines; Pyrroles; Rats; Rats, Wistar

Topics: Binding Sites; Cell Survival; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Humans; Molecular Docking Simulation; Oxadiazoles; Protein Binding; Pyridazines; Pyrroles; THP-1 Cells

Topics: Anti-Bacterial Agents; Bacteria; Biofilms; Chloramines; Escherichia coli; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxadiazoles; Pseudomonas aeruginosa; Pyrroles; Staphylococcus aureus

Topics: Aldehydes; Antineoplastic Agents; Caco-2 Cells; Cell Proliferation; Chloramines; Dimethyl Sulfoxide; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Ethanol; Humans; Molecular Docking Simulation; Molecular Structure; Oxadiazoles; Pemetrexed; Pyrroles; Structure-Activity Relationship; Thymidylate Synthase

Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents; Bacteria; Microbial Sensitivity Tests; Oxadiazoles; Pyrroles; Structure-Activity Relationship