pyrroles has been researched along with monocrotaline in 50 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (20.00) | 18.7374 |
| 1990's | 9 (18.00) | 18.2507 |
| 2000's | 8 (16.00) | 29.6817 |
| 2010's | 18 (36.00) | 24.3611 |
| 2020's | 5 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Johnson, WD; Lalich, JL; Raczniak, TJ; Shumaker, RC | 1 |
| Ciaramitaro, D; Eisenstein, D; Huxtable, R | 1 |
| Huxtable, RJ; Nigra, L | 1 |
| Glowaz, SL; Huxtable, RJ; Michnika, M | 1 |
| Hopkins, PB; Sigurdsson, ST; Weidner, MF | 1 |
| Braun, RC; Dickinson, JO | 1 |
| Huxtable, RJ; Lafranconi, WM; Ohkuma, S | 1 |
| Garcia, CM; Hilliker, KS; Roth, RA | 1 |
| Gupta, RL; Juneja, TR; Samanta, S | 1 |
| Gamble, W; Meyrick, B; Reid, L | 1 |
| Driver, HE; Mattocks, AR | 1 |
| Horwitz, LD; Kuriyama, T; Latham, LP; Sawada, A; Sugita, T; Wagner, WW; Watanabe, S | 1 |
| Legg, RF; Mattocks, AR | 1 |
| Huxtable, RJ; Yan, CC | 4 |
| Jones, AD; Lamé, MW; Morin, D; Segall, HJ; Wilson, DW | 1 |
| Cooper, RA; Huxtable, RJ; Yan, CC | 1 |
| Cowan, KN; Heilbut, A; Humpl, T; Ito, S; Lam, C; Rabinovitch, M | 1 |
| Copple, BL; Ganey, PE; Hanumegowda, UM; Roth, RA; Shibuya, M; Yee, SB | 1 |
| Fu, LJ; Li, F; Shen, J; Zhao, W; Zhou, AQ | 1 |
| Coulombe, RA; Rieben, WK | 1 |
| Bardou, M; Dumas, M; Goirand, F; Guerard, P; Lirussi, F; Rakotoniaina, Z; Rochette, L | 2 |
| Archer, SL; Bonnet, S; Haromy, A; McMurtry, MS; Michelakis, ED | 1 |
| Satoh, A; Satoh, M | 1 |
| Ozturk, EI; Uma, S | 1 |
| Fan, ZX; Gao, YF; Jing, ZC; Li, J; Li, L; Ma, D; Shi, DM; Wang, YW; Wu, BX; Zhu, XD | 1 |
| Lin, P; Xie, H; Xie, L; Xu, C | 1 |
| Ambalavanan, N; Järvinen, TA; Komatsu, M; Mann, D; McMurtry, I; Oka, M; Ruoslahti, E; Sawada, J; Toba, M; Urakami, T | 1 |
| Chen, D; Chen, F; Dong, L; Ge, J; Guan, L; Qian, J; Zhou, D | 1 |
| Best, J; Chwalek, K; Egemnazarov, B; Eickelberg, O; Fink, L; Kwapiszewska, G; Marsh, LM; Olschewski, A; Osswald, SL; Schermuly, RT; Seeger, W; Weisel, FC; Weissmann, N; Wilhelm, J; Wygrecka, M | 1 |
| Barrier, M; Biardel, S; Bisserier, M; Bonnet, P; Bonnet, S; Breuils-Bonnet, S; Carter, S; Courchesne, A; Courture, C; Deshaies, Y; Lauzon-Joset, JF; Majka, SM; Meloche, J; Paulin, R; Picard, F; Provencher, S; Racine, C; Tremblay, É | 1 |
| Aboagye, EO; Ashek, A; Barnes, G; Cotroneo, E; Cupitt, J; Dabral, S; Dubois, O; El-Bahrawy, MA; Fang, W; Gibbs, JS; Gsell, W; He, JG; Howard, LS; Jones, H; Nguyen, QD; Pullamsetti, SS; Tomasi, G; Wang, L; Wilkins, MR; Zhao, L | 1 |
| Bálint, Z; Crnkovic, S; Egemnazarov, B; Gattinger, N; Ghanim, B; Jain, P; Klepetko, W; Kovacs, G; Kwapiszewska, G; Marsh, LM; Olschewski, A; Schermuly, RT; Seay, U; Weissmann, N | 1 |
| Asmis, R; Barabutis, N; Barman, SA; Black, SM; Catravas, JD; Chen, F; Dimitropoulou, C; Fulton, DJ; Giannis, A; Han, W; Jonigk, D; Keri, G; Orfi, L; Rafikov, R; Rafikova, O; Ramesh, G; Stepp, DW; Su, Y; Szabadkai, I; Szantai-Kis, C; Wang, Y | 1 |
| Chun, HJ; Comhair, SA; Erzurum, SC; Hu, X; Hwangbo, C; Ju, H; Kang, Y; Kim, J; McLean, DL; Mehrotra, D; Papangeli, I; Park, H | 1 |
| Chen, G; He, Y; Jia, D; Liu, H; Lu, A; Zhu, Q; Zuo, C | 1 |
| Higuchi, M; Hikasa, Y; Leong, ZP; Okida, A; Yamano, Y | 1 |
| Hikasa, Y; Leong, ZP | 1 |
| Bai, P; Fu, J; He, Y; Jia, D; Lyu, A; Lyu, L; Wan, N; Wan, Q; Yu, T; Zuo, C | 1 |
| Bisserier, M; Bridges, CR; Fargnoli, AS; Gubara, SM; Hadri, L; Hajjar, RJ; Katz, MG; Sassi, Y | 1 |
| Baal, N; Dorfmuller, P; Ghofrani, HA; Grimminger, F; Jonigk, D; Kojonazarov, B; Neubauer, MC; Neubert, L; Pullamsetti, SS; Ruppert, C; Schermuly, RT; Schlueter, BC; Seeger, W; Weiss, A; Weissmann, N; Yerabolu, D | 1 |
| Al-Mamun, ME; Aoki, J; Doi, T; Kano, K; Kikuchi, H; Kikuchi, N; Kurosawa, R; Matsumoto, Y; Miyata, S; Nogi, M; Numano, K; Omura, J; Oshima, Y; Saigusa, D; Satoh, K; Satoh, T; Shimokawa, H; Siddique, MAH; Sunamura, S; Uruno, A; Yamamoto, M | 1 |
| Fu, PP; He, Y; Lin, G; Ma, J; Song, Z | 1 |
| Higuchi, T; Inagaki, T; Masaki, T; Nakaoka, Y; Pearson, JT; Saito, S; Schwenke, DO; Shirai, M; Tsuchimochi, H; Umetani, K | 1 |
| Banerjee, S; Clark, VR; Fishbein, G; Hong, J; Park, JF; Razee, A; Saddic, L; Umar, S; Williams, T | 1 |
| Awada, C; Bonnet, S; Boucherat, O; Bourgeois, A; Breuils-Bonnet, S; Grobs, Y; Lemay, SE; Nadeau, V; Orcholski, M; Paulin, R; Provencher, S; Romanet, C; Shimauchi, K; Toro, V; Tremblay, E | 1 |
| Ben-Batalla, I; Caruso, P; Gall, H; Ghofrani, HA; Götz, E; Grimminger, F; Herpel, S; Kojonazarov, B; Lepper, C; Loges, S; Manaud, G; Morrell, NW; Novoyatleva, T; Perros, F; Presser, N; Rai, N; Schermuly, RT; Seeger, W; Shihan, M; Upton, PD; Veeroju, S; Weissmann, N; Wharton, J; Wilkins, M | 1 |
1 trial(s) available for pyrroles and monocrotaline
| Article | Year |
|---|---|
Heterogeneity in lung (18)FDG uptake in pulmonary arterial hypertension: potential of dynamic (18)FDG positron emission tomography with kinetic analysis as a bridging biomarker for pulmonary vascular remodeling targeted treatments.
Topics: Adult; Aged; Animals; Benzamides; Cell Division; Dichloroacetic Acid; Disease Models, Animal; Drug Monitoring; Familial Primary Pulmonary Hypertension; Female; Fibroblasts; Fluorine Radioisotopes; Fluorodeoxyglucose F18; Gene Expression Profiling; Glycolysis; Humans; Hypertension, Pulmonary; Imatinib Mesylate; Indoles; Lung; Male; Middle Aged; Monocrotaline; Piperazines; Positron-Emission Tomography; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Sunitinib; Young Adult | 2013 |
49 other study(ies) available for pyrroles and monocrotaline
| Article | Year |
|---|---|
Fibrin thrombosis in monocrotaline pyrrole-induced cor pulmonale in rats.
Topics: Animals; Cardiomegaly; Endothelium; Fibrin; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Pulmonary Embolism; Pulmonary Heart Disease; Pyrroles; Pyrrolizidine Alkaloids; Rats | 1977 |
The effect of a pyrrolizidine alkaloid, monocrotaline, and a pyrrole, dehydroretronecine, on the biochemical functions of the pulmonary endothelium.
Topics: Adenosine Monophosphate; Animals; Blood Pressure; Endothelium; Heart; In Vitro Techniques; Leucine; Lung; Male; Monocrotaline; Norepinephrine; Organ Size; Plants, Toxic; Pyrroles; Pyrrolizidine Alkaloids; Rats; Senecio; Serotonin; Time Factors; Tissue Distribution | 1978 |
Hepatic glutathione concentrations and the release of pyrrolic metabolites of the pyrrolizidine alkaloid, monocrotaline, from the isolated perfused liver.
Topics: Animals; Benzaldehydes; Bile; Glutathione; In Vitro Techniques; Liver; Male; Monocrotaline; Perfusion; Pyrroles; Rats; Rats, Sprague-Dawley | 1992 |
Detection of a reactive pyrrole in the hepatic metabolism of the pyrrolizidine alkaloid, monocrotaline.
Topics: Animals; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; In Vitro Techniques; Male; Mass Spectrometry; Microsomes, Liver; Monocrotaline; Pyrroles; Rats | 1992 |
Sequence preferences of DNA interstrand cross-linking agents: dG-to-dG cross-linking at 5'-CG by structurally simplified analogues of mitomycin C.
Topics: Base Sequence; Cross-Linking Reagents; DNA; Mitomycin; Mitomycins; Molecular Sequence Data; Monocrotaline; Nucleic Acid Conformation; Pyrroles; Pyrrolizidine Alkaloids | 1990 |
Effect of 2(3)-tert-butyl-4-hydroxyanisole (BHA) and 2-chloroethanol against pyrrole production and chronic toxicity of monocrotaline in chickens.
Topics: Animals; Body Weight; Butylated Hydroxyanisole; Chickens; Chlorohydrins; Ethylene Chlorohydrin; Female; Liver; Male; Monocrotaline; Organ Size; Pyrroles; Pyrrolizidine Alkaloids | 1987 |
Biliary excretion of novel pneumotoxic metabolites of the pyrrolizidine alkaloid, monocrotaline.
Topics: Animals; Bile; Chromatography, Thin Layer; Colorimetry; In Vitro Techniques; Liver; Lung; Male; Mass Spectrometry; Monocrotaline; Pyrroles; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Serotonin | 1985 |
Effects of monocrotaline and monocrotaline pyrrole on 5-hydroxytryptamine and paraquat uptake by lung slices.
Topics: Animals; Benzaldehydes; In Vitro Techniques; Lung; Male; Monocrotaline; Paraquat; Pentobarbital; Pyrroles; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Serotonin | 1983 |
Activation of monocrotaline, fulvine and their derivatives to toxic pyrroles by some thiols.
Topics: Biotransformation; Chemical Phenomena; Chemistry; Monocrotaline; Pyrroles; Pyrrolizidine Alkaloids; Sulfhydryl Compounds | 1984 |
Development of Crotalaria pulmonary hypertension: hemodynamic and structural study.
Topics: Animals; Blood Gas Analysis; Body Temperature; Cardiomegaly; Hemodynamics; Hypertension, Pulmonary; Male; Monocrotaline; Pulmonary Circulation; Pyrroles; Pyrrolizidine Alkaloids; Rats | 1980 |
A comparison of the pneumotoxicity of some pyrrolic esters and similar compounds analogous to pyrrolizidine alkaloid metabolites, given intravenously to rats.
Topics: Animals; Female; Injections, Intravenous; Liver; Lung; Male; Monocrotaline; Pyrroles; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1983 |
[Experimental pulmonary hypertension (author's transl)].
Topics: Animals; Cattle; Dogs; Hypertension, Pulmonary; Hypoxia; Monocrotaline; Pyrroles; Pyrrolizidine Alkaloids; Rabbits; Rats; Sheep; Species Specificity; Swine | 1981 |
Antimitotic activity of dehydroretronecine, a pyrrolizidine alkaloid metabolite, and some analogous compounds, in a rat liver parenchymal cell line.
Topics: Animals; Cell Line; Cell Survival; Liver; Mitosis; Monocrotaline; Pyrroles; Pyrrolizidine Alkaloids; Rats; Structure-Activity Relationship | 1980 |
Effect of the pyrrolizidine alkaloid, monocrotaline, on bile composition of the isolated, perfused rat liver.
Topics: Amino Acids; Animals; Bile; Cysteine; Dipeptides; Glutathione; In Vitro Techniques; Monocrotaline; Pyrroles; Rats; Rats, Sprague-Dawley | 1995 |
Biliary excretion of pyrrolic metabolites of [14C]monocrotaline in the rat.
Topics: Animals; Bile; Carbon Radioisotopes; Electrophoresis, Polyacrylamide Gel; In Vitro Techniques; Isoelectric Focusing; Liver; Male; Monocrotaline; Pyrroles; Rats; Rats, Sprague-Dawley | 1995 |
The comparative metabolism of the four pyrrolizidine alkaloids, seneciphylline, retrorsine, monocrotaline, and trichodesmine in the isolated, perfused rat liver.
Topics: Alkaloids; Analysis of Variance; Animals; Antineoplastic Agents, Phytogenic; Bile; Glutathione; Lethal Dose 50; Liver; Male; Monocrotaline; Perfusion; Pyrroles; Pyrrolizidine Alkaloids; Rats; Rats, Sprague-Dawley; Spectrophotometry, Ultraviolet; Structure-Activity Relationship | 1995 |
The effect of the pyrrolizidine alkaloids, monocrotaline and trichodesmine, on tissue pyrrole binding and glutathione metabolism in the rat.
Topics: Alkaloids; Animals; Brain; Glutathione; Liver; Lung; Male; Monocrotaline; Organ Specificity; Pyrroles; Rats; Rats, Sprague-Dawley | 1995 |
The relationship between the concentration of the pyrrolizidine alkaloid monocrotaline and the pattern of metabolites released from the isolated liver.
Topics: Analysis of Variance; Animals; Bile; Carcinogens; Dose-Response Relationship, Drug; Glutathione; In Vitro Techniques; Liver; Mass Spectrometry; Monocrotaline; Perfusion; Pyrroles; Rats | 1995 |
Relationship between glutathione concentration and metabolism of the pyrrolizidine alkaloid, monocrotaline, in the isolated, perfused liver.
Topics: Analysis of Variance; Animals; Antimetabolites, Antineoplastic; Bile; Buthionine Sulfoximine; Ethylene Chlorohydrin; Glutathione; Liver; Male; Maleates; Methionine Sulfoximine; Monocrotaline; Perfusion; Pyrroles; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidines | 1995 |
Complete reversal of fatal pulmonary hypertension in rats by a serine elastase inhibitor.
Topics: Animals; Disease Models, Animal; Hypertension, Pulmonary; Male; Monocrotaline; Pancreatic Elastase; Protease Inhibitors; Pyrroles; Rats; Rats, Sprague-Dawley; Sulfonamides | 2000 |
Endothelial cell injury and coagulation system activation during synergistic hepatotoxicity from monocrotaline and bacterial lipopolysaccharide coexposure.
Topics: Animals; Blood Coagulation; Chemical and Drug Induced Liver Injury; Drug Synergism; Endothelial Cells; Fibrin; Fibrinogen; Hemoglobins; Immunoblotting; Immunohistochemistry; Lipopolysaccharides; Male; Microscopy, Electron, Scanning; Microsomes, Liver; Monocrotaline; Poisons; Pyrroles; Rats; Rats, Sprague-Dawley | 2003 |
[Effect of elastase inhibitor on pulmonary hypertension induced by monocrotaline].
Topics: Animals; Hypertension, Pulmonary; Male; Monocrotaline; Pancreatic Elastase; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; Sulfonamides | 2004 |
DNA cross-linking by dehydromonocrotaline lacks apparent base sequence preference.
Topics: Amino Acids; Aspartic Acid; Base Sequence; Chromatography, High Pressure Liquid; Cross-Linking Reagents; Cysteine; DNA; Electrophoretic Mobility Shift Assay; Glutathione; Indicators and Reagents; Monocrotaline; Nucleic Acid Denaturation; Oligonucleotides; Pyrroles; Tyrosine | 2004 |
The protective effect of HMG-CoA reductase inhibitors against monocrotaline-induced pulmonary hypertension in the rat might not be a class effect: comparison of pravastatin and atorvastatin.
Topics: Acetylcholine; Animals; Apoptosis; Atorvastatin; Caspase 3; Endothelial Cells; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Nitric Oxide Synthase Type III; Nitroprusside; Pravastatin; Pulmonary Artery; Pyrroles; Rats; Rats, Wistar; Ventricular Pressure | 2006 |
Statin therapy, alone or with rapamycin, does not reverse monocrotaline pulmonary arterial hypertension: the rapamcyin-atorvastatin-simvastatin study.
Topics: Animals; Atorvastatin; Blood Pressure; Disease Progression; Dose-Response Relationship, Drug; Drug Synergism; Echocardiography; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Male; Monocrotaline; Phosphorylation; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases, 70-kDa; Simvastatin; Sirolimus | 2007 |
Celecoxib but not the combination of celecoxib+atorvastatin prevents the development of monocrotaline-induced pulmonary hypertension in the rat.
Topics: Acetylcholine; Animals; Atorvastatin; Blotting, Western; Body Weight; Caspase 3; Celecoxib; Cyclooxygenase Inhibitors; Disease Progression; Drug Combinations; Hemodynamics; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocardium; Nitric Oxide Synthase Type III; Pulmonary Artery; Pyrazoles; Pyrroles; Rats; Rats, Wistar; Sulfonamides; Survival Analysis; Vasodilator Agents | 2008 |
3-Hydroxy-3-methylglutaryl (HMG)-COA reductase inhibitors and phosphodiesterase type V inhibitors attenuate right ventricular pressure and remodeling in a rat model of pulmonary hypertension.
Topics: Animals; Atorvastatin; Disease Models, Animal; Hemodynamics; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Male; Monocrotaline; Phosphodiesterase Inhibitors; Pravastatin; Pulmonary Artery; Pyrroles; Rats; Rats, Wistar; Simvastatin | 2009 |
Effects of atorvastatin and L-arginine treatments on electrical field stimulation-mediated relaxations in pulmonary arterial rings of monocrotaline-induced pulmonary hypertensive rats.
Topics: Animals; Arginine; Atorvastatin; Electric Stimulation; Endothelium, Vascular; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; In Vitro Techniques; Male; Monocrotaline; Nitric Oxide; Nitric Oxide Synthase Type III; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; Vasodilation | 2010 |
The effects of atorvastatin on pulmonary arterial hypertension and expression of p38, p27, and Jab1 in rats.
Topics: Animals; Atorvastatin; COP9 Signalosome Complex; Gene Expression Regulation; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Intracellular Signaling Peptides and Proteins; Male; Monocrotaline; p38 Mitogen-Activated Protein Kinases; Pneumonectomy; Proliferating Cell Nuclear Antigen; Proteins; Pulmonary Artery; Pyrroles; Rats; Rats, Wistar | 2010 |
Effects of atorvastatin and losartan on monocrotaline-induced pulmonary artery remodeling in rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Arterioles; Atorvastatin; Base Sequence; Calcium Channels, L-Type; Disease Models, Animal; DNA Primers; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Inositol 1,4,5-Trisphosphate Receptors; Losartan; Male; Monocrotaline; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; RNA, Messenger; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum Calcium-Transporting ATPases | 2010 |
Peptide-directed highly selective targeting of pulmonary arterial hypertension.
Topics: Amino Acid Sequence; Animals; Drug Delivery Systems; Humans; Hypertension, Pulmonary; Hypoxia; Indoles; Lung; Male; Molecular Sequence Data; Monocrotaline; Peptides; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Vascular Endothelial Growth Factor; Time Factors | 2011 |
Atorvastatin prevents dehydromonocrotaline-induced pulmonary hypertension in beagles.
Topics: Alkylating Agents; Animals; Atorvastatin; Cell Proliferation; Cytokines; Dogs; Endothelium, Vascular; Female; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Muscle, Smooth, Vascular; Nitric Oxide Synthase Type III; Pyrroles | 2012 |
BDNF/TrkB signaling augments smooth muscle cell proliferation in pulmonary hypertension.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cell Hypoxia; Cell Proliferation; Disease Models, Animal; DNA; Early Growth Response Protein 1; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Humans; Hypertension, Pulmonary; Indoles; Ligands; Lung; Male; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Monocrotaline; Myocytes, Smooth Muscle; Protein Binding; Pyrroles; Rats; Receptor, trkB; Signal Transduction | 2012 |
Critical role for the advanced glycation end-products receptor in pulmonary arterial hypertension etiology.
Topics: Adult; Aged; Animals; Apoptosis; Arterial Pressure; Bone Morphogenetic Protein Receptors, Type II; Case-Control Studies; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Female; Glycation End Products, Advanced; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Indoles; Male; Middle Aged; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; PPAR gamma; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; Receptor for Advanced Glycation End Products; Receptors, Immunologic; RNA Interference; S100 Proteins; Signal Transduction; STAT3 Transcription Factor; Transfection; Up-Regulation | 2013 |
NPY/Y₁ receptor-mediated vasoconstrictory and proliferative effects in pulmonary hypertension.
Topics: Adult; Animals; Arginine; Cell Proliferation; Epinephrine; Female; Humans; Hypertension, Pulmonary; Hypoxia; In Vitro Techniques; Indoles; Lung; Male; Mice, Inbred C57BL; Monocrotaline; Myocytes, Smooth Muscle; Neuropeptide Y; Pulmonary Artery; Pyrroles; Rats, Sprague-Dawley; Receptors, Neuropeptide Y; Vasoconstriction; Vasoconstrictor Agents; Young Adult | 2014 |
NADPH oxidase 4 is expressed in pulmonary artery adventitia and contributes to hypertensive vascular remodeling.
Topics: Adventitia; Animals; Antihypertensive Agents; Cell Movement; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Matrix; Familial Primary Pulmonary Hypertension; Fibroblasts; HEK293 Cells; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Indoles; Male; Mice; Mice, Inbred C57BL; Monocrotaline; NADPH Oxidase 4; NADPH Oxidases; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction; Time Factors; Transfection; Up-Regulation | 2014 |
Restoration of impaired endothelial myocyte enhancer factor 2 function rescues pulmonary arterial hypertension.
Topics: Animals; Apelin; Arterioles; Cells, Cultured; Disease Models, Animal; Drug Evaluation, Preclinical; Endothelial Cells; Fibroblast Growth Factor 2; Hemodynamics; Histone Deacetylase Inhibitors; Hydroxamic Acids; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Intercellular Signaling Peptides and Proteins; Male; MEF2 Transcription Factors; MicroRNAs; Monocrotaline; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; RNA Interference; RNA, Small Interfering; Transcription, Genetic | 2015 |
Osteoprotegerin Disruption Attenuates HySu-Induced Pulmonary Hypertension Through Integrin αvβ3/FAK/AKT Pathway Suppression.
Topics: Animals; Arterial Pressure; Case-Control Studies; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Female; Focal Adhesion Kinase 1; Humans; Hypertension, Pulmonary; Hypoxia; Indoles; Integrin alphaVbeta3; Male; Mice, Knockout; Middle Aged; Monocrotaline; Muscle, Smooth, Vascular; Osteoprotegerin; Proto-Oncogene Proteins c-akt; Pulmonary Artery; Pyrroles; Rats, Sprague-Dawley; RNA Interference; Severity of Illness Index; Signal Transduction; Transfection; Vascular Remodeling; Walk Test | 2017 |
Reversal effects of low-dose imatinib compared with sunitinib on monocrotaline-induced pulmonary and right ventricular remodeling in rats.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Imatinib Mesylate; Indoles; Male; Monocrotaline; Nestin; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-raf; Pulmonary Artery; Pyrroles; Rats, Wistar; Receptor, Fibroblast Growth Factor, Type 1; Receptor, Platelet-Derived Growth Factor beta; Signal Transduction; Sunitinib; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2; Vascular Remodeling; Ventricular Function, Right; Ventricular Remodeling | 2018 |
Effects of toceranib compared with sorafenib on monocrotaline-induced pulmonary arterial hypertension and cardiopulmonary remodeling in rats.
Topics: Animals; Antihypertensive Agents; Arterial Pressure; Autophagy; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Indoles; Male; Monocrotaline; Niacinamide; Phenylurea Compounds; Protein Kinase Inhibitors; Pulmonary Artery; Pyrroles; Rats, Wistar; Signal Transduction; Sorafenib; Vascular Remodeling; Ventricular Function, Right; Ventricular Remodeling | 2018 |
Macrophage-Derived Legumain Promotes Pulmonary Hypertension by Activating the MMP (Matrix Metalloproteinase)-2/TGF (Transforming Growth Factor)-β1 Signaling.
Topics: Animals; Caspase Inhibitors; Cysteine Endopeptidases; Extracellular Matrix Proteins; Female; Follow-Up Studies; Humans; Hypertension, Pulmonary; Hypoxia; Indoles; Inflammation; Lung; Macrophages; Male; Matrix Metalloproteinase 2; Mice; Middle Aged; Monocrotaline; Pyrroles; Rats; Severity of Illness Index; Signal Transduction; Transforming Growth Factor beta1; Vascular Remodeling | 2019 |
The Left Pneumonectomy Combined with Monocrotaline or Sugen as a Model of Pulmonary Hypertension in Rats.
Topics: Animals; Disease Models, Animal; Hypertension, Pulmonary; Indoles; Lung; Male; Monocrotaline; Pneumonectomy; Pulmonary Artery; Pyrroles; Rats, Sprague-Dawley | 2019 |
Targeting cyclin-dependent kinases for the treatment of pulmonary arterial hypertension.
Topics: Animals; Cell Line; Cyclin-Dependent Kinases; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Humans; Indoles; Lung; Male; Mice; Mice, Inbred C57BL; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Piperazines; Protein Kinase Inhibitors; Pulmonary Artery; Pyridines; Pyrroles; Rats; Rats, Inbred WKY; Rats, Sprague-Dawley; Treatment Outcome | 2019 |
Identification of Celastramycin as a Novel Therapeutic Agent for Pulmonary Arterial Hypertension.
Topics: Animals; Cells, Cultured; Cytokines; Disease Models, Animal; Drug Evaluation, Preclinical; Energy Metabolism; High-Throughput Screening Assays; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Indoles; Male; Metabolome; Mice; Mitochondria; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Naphthoquinones; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Pulmonary Arterial Hypertension; Pulmonary Artery; Pyrroles; Rats; Reactive Oxygen Species; Resorcinols; Transcription Factors | 2019 |
Pulmonary toxicity is a common phenomenon of toxic pyrrolizidine alkaloids.
Topics: Activation, Metabolic; Animals; Drug-Related Side Effects and Adverse Reactions; Drugs, Chinese Herbal; Liver; Lung; Monocrotaline; Proteins; Pyrroles; Pyrrolizidine Alkaloids; Rats | 2020 |
Evaluation of right coronary vascular dysfunction in severe pulmonary hypertensive rats using synchrotron radiation microangiography.
Topics: Animals; Antihypertensive Agents; Coronary Angiography; Coronary Vessels; Disease Models, Animal; Endothelin Receptor Antagonists; Endothelin-1; Hypertrophy, Right Ventricular; Hypoxia; Indoles; Monocrotaline; Predictive Value of Tests; Pulmonary Arterial Hypertension; Pyrimidines; Pyrroles; Rats, Sprague-Dawley; Severity of Illness Index; Sulfonamides; Synchrotrons; Vasodilation; Ventricular Dysfunction, Right; Ventricular Function, Right; Ventricular Remodeling | 2021 |
Transcriptomic Analysis of Right Ventricular Remodeling in Two Rat Models of Pulmonary Hypertension: Identification and Validation of Epithelial-to-Mesenchymal Transition in Human Right Ventricular Failure.
Topics: Aged; Aged, 80 and over; Angiogenesis Inhibitors; Animals; Disease Models, Animal; Epithelial-Mesenchymal Transition; Female; Gene Expression Profiling; Heart Failure; Heart Ventricles; Humans; Hypoxia; Indoles; Male; Middle Aged; Monocrotaline; Pulmonary Arterial Hypertension; Pyrroles; Rats; Real-Time Polymerase Chain Reaction; RNA-Seq; Transcriptome; Ventricular Dysfunction, Right; Ventricular Remodeling | 2021 |
Preclinical Investigation of Trifluoperazine as a Novel Therapeutic Agent for the Treatment of Pulmonary Arterial Hypertension.
Topics: Animals; Antipsychotic Agents; Cardiovascular Agents; Cell Proliferation; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Repositioning; Female; Forkhead Box Protein O3; Gene Expression Regulation; Hemodynamics; Humans; Hypertension, Pulmonary; Hypoxia; Indoles; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Primary Cell Culture; Proto-Oncogene Proteins c-akt; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; Survivin; Trifluoperazine | 2021 |
Deficiency of Axl aggravates pulmonary arterial hypertension via BMPR2.
Topics: Angiogenesis Inhibitors; Animals; Bone Morphogenetic Protein Receptors, Type II; Gene Expression Regulation; Indoles; Male; Monocrotaline; Pulmonary Arterial Hypertension; Pyrroles; Rats, Inbred WKY; Rats, Sprague-Dawley; Receptor Protein-Tyrosine Kinases | 2021 |