pyrroles and mevalonic acid

Topics: Animals; Anticholesteremic Agents; Atorvastatin; Cell Division; Cytochrome P-450 Enzyme System; Drug Interactions; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Mevalonic Acid; Pyridines; Pyrroles; Simvastatin

Topics: Alendronate; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Bone Density Conservation Agents; Denosumab; Diphosphonates; Etidronic Acid; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ibandronic Acid; Imidazoles; Indoles; Jaw Diseases; Macrophages; Magnetic Resonance Imaging; Mevalonic Acid; Monocytes; Mouth Mucosa; Osteoclasts; Osteomyelitis; Osteonecrosis; Positron-Emission Tomography; Pyrroles; Radiography, Panoramic; RANK Ligand; Risedronic Acid; Risk Factors; Signal Transduction; Sunitinib; Tomography, X-Ray Computed; Vitamin D; Zoledronic Acid

Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosphate; Adsorption; Adult; Africa, Eastern; Aged; Air Pollutants; Air Pollution; Air Pollution, Indoor; Alcohol Drinking; Allergens; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Animals; Anti-Bacterial Agents; Antibodies; Antibodies, Immobilized; Antigen Presentation; Antigens, CD; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Apoptosis; Aptamers, Nucleotide; Asthma; Asthma, Exercise-Induced; Atrophy; Autophagy; Azoospermia; Bacillus cereus; Bacterial Infections; Beclin-1; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Biofouling; Biological Monitoring; Biomarkers; Biomarkers, Tumor; Biosensing Techniques; Blastocyst; Bone Neoplasms; Bone Regeneration; Bronchoconstriction; Burkitt Lymphoma; C9orf72 Protein; Campylobacter; Campylobacter Infections; Campylobacter jejuni; Carcinogenesis; Carcinoma, Hepatocellular; Carcinoma, Pancreatic Ductal; Carcinoma, Squamous Cell; Cardiomyopathies; Caregivers; Carmine; Case-Control Studies; Catalysis; Cattle; Cause of Death; CCAAT-Enhancer-Binding Protein-alpha; CD8-Positive T-Lymphocytes; Cefepime; Cell Differentiation; Cell Line, Tumor; Cell Nucleus; Cell Transdifferentiation; Chelating Agents; Chemical and Drug Induced Liver Injury, Chronic; Chemoradiotherapy, Adjuvant; Child; Child, Preschool; China; Chlorquinaldol; Cholangiocarcinoma; Cholera; Chromatin; Clinical Trials as Topic; Cognitive Dysfunction; Cohort Studies; Colonic Neoplasms; Colorectal Neoplasms; Colorimetry; Cooking; Coordination Complexes; COVID-19; Creatinine; CRISPR-Cas Systems; Critical Care; Critical Illness; Cross-Sectional Studies; Cryopreservation; Cryoprotective Agents; Cysteine; Cytokines; Device Removal; Diet; Diet, High-Fat; Diet, Mediterranean; Dietary Supplements; Dimethyl Sulfoxide; Dipeptides; Disease Models, Animal; Dithiothreitol; DNA; DNA Repeat Expansion; DNA, Bacterial; DNA, Complementary; Dopamine; Electrochemical Techniques; Electrodes; Endocannabinoids; Environmental Exposure; Environmental Monitoring; Environmental Pollutants; Enzyme-Linked Immunosorbent Assay; Erlotinib Hydrochloride; Escherichia coli; Escherichia coli O157; Esophageal Neoplasms; Esophagitis, Peptic; Ethylene Glycol; Europium; Exanthema; Fallopian Tubes; Feces; Female; Fertilization in Vitro; Fluoresceins; Fluorescent Dyes; Follicle Stimulating Hormone; Follow-Up Studies; Food Microbiology; Forced Expiratory Volume; Forkhead Transcription Factors; Frontotemporal Dementia; G-Quadruplexes; Galactose; Gastroenteritis; Gastrointestinal Diseases; Gastrointestinal Microbiome; Gastrointestinal Neoplasms; Gastrointestinal Tract; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Genital Neoplasms, Female; Genome-Wide Association Study; Genome, Viral; Genomics; Genotype; Glucose; Glutathione; Glycerol; Gold; Graphite; GTPase-Activating Proteins; Heat-Shock Proteins; Heme Oxygenase-1; Hepacivirus; Hepatitis C; Hepatocytes; Histamine; Histocompatibility Antigens Class II; Hoarseness; Hospice and Palliative Care Nursing; Humans; Hydrogen; Hydrogen Peroxide; Hydrogen Sulfide; Hydroxybenzoates; Hydroxyl Radical; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperthermia, Induced; Hysteroscopy; Immunoassay; Indigo Carmine; Inflammation; Inflammatory Bowel Diseases; Insulin Resistance; Intensive Care Units; Interleukin-11; Interleukin-6; Interleukins; Iodine Radioisotopes; Iran; Iridium; Islets of Langerhans; Kinetics; Lactation; Lactobacillus; Lactobacillus plantarum; Lamins; Latin America; Lead; Lectins; Leukopenia; Ligands; Limit of Detection; Lipopolysaccharides; Lipoprotein Lipase; Liver; Liver Cirrhosis; Liver Neoplasms; Lolium; Luminescent Measurements; Luminol; Lung; Luteinizing Hormone; Macrophages; Magnetic Phenomena; Magnetic Resonance Imaging; Male; Malnutrition; Maltose; Manganese Compounds; Maternal Nutritional Physiological Phenomena; Melatonin; Metabolic Engineering; Metal Nanoparticles; Metallocenes; Metaplasia; Methicillin-Resistant Staphylococcus aureus; Methylation; Mevalonic Acid; Mexico; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microbial Sensitivity Tests; Microbiota; MicroRNAs; Milk; Mitomycin; Molecular Diagnostic Techniques; Molecular Docking Simulation; Monte Carlo Method; Moringa oleifera; Multiple Sclerosis; Muscle Strength; Muscle, Skeletal; Nanocomposites; Nanotubes, Carbon; Neoadjuvant Therapy; Neoplasms; Neurodegenerative Diseases; Neurotransmitter Agents; NF-E2-Related Factor 2; Nickel; Nitrogen Dioxide; Non-alcoholic Fatty Liver Disease; Nucleic Acid Amplification Techniques; Nucleic Acid Hybridization; Nucleocapsid Proteins; Nutritional Status; Obesity; Osteogenesis; Osteosarcoma; Oxidation-Reduction; Oxides; Oxygen; Oxyquinoline; Pain; Palliative Care; Pancreatic Neoplasms; Pandemics; Particulate Matter; Peroxidase; Peroxidases; Phagocytosis; Phaseolus; Photothermal Therapy; Point-of-Care Systems; Polyethyleneimine; Polymers; Polymorphism, Single Nucleotide; Polysomnography; Postoperative Complications; Pregnancy; Pregnant Women; Prenatal Exposure Delayed Effects; Prevalence; Printing, Three-Dimensional; Probability; Probiotics; Prognosis; Prophages; Prospective Studies; Proteomics; Proto-Oncogene Proteins; Pseudomonas aeruginosa; Pseudomonas putida; Pulmonary Disease, Chronic Obstructive; Pulmonary Embolism; Pyridines; Pyrroles; Quality of Life; Quinolones; Rabbits; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Receptors, Histamine; Receptors, Histamine H2; Recombinases; Rectal Neoplasms; Reperfusion Injury; Respiration; Respiratory Function Tests; Respiratory Rate; Respiratory Sounds; Retrospective Studies; rho GTP-Binding Proteins; Risk Assessment; Risk Factors; RNA; RNA, Messenger; RNA, Ribosomal, 16S; Robotic Surgical Procedures; Running; Rural Population; Saccharomyces cerevisiae; Salpingectomy; Sarcopenia; SARS-CoV-2; Seeds; Semen; Sensitivity and Specificity; Sepsis; Shock, Septic; Signal Transduction; Silicon Dioxide; Silver; Sirtuin 1; Skin Neoplasms; Sleep Apnea, Obstructive; Soil; Spain; Spectrum Analysis, Raman; Sperm Retrieval; Spermatozoa; Spirometry; Staphylococcus aureus; STAT3 Transcription Factor; Stereoisomerism; Sterilization, Tubal; Stroke Volume; Sulfadiazine; Sulfites; Superoxide Dismutase; Surface Plasmon Resonance; tau Proteins; Testis; Testosterone; Thioredoxin-Disulfide Reductase; Thyroid Neoplasms; Thyroidectomy; Trans-Activators; Transcription Factor AP-1; Treatment Outcome; Triazoles; Triclosan; Trifluridine; Tumor Microenvironment; Tumor Necrosis Factor-alpha; United States; Uracil; Vagina; Vegetables; Ventricular Function, Left; Ventricular Pressure; Vibrio cholerae; Vietnam; Virulence; Vital Capacity; Vitrification; Walking; Water; Water Pollutants, Radioactive; Whole Genome Sequencing; Wind; YAP-Signaling Proteins; Zeolites; Zinc Oxide

Topics: Anticholesteremic Agents; Atorvastatin; Cholesterol; Cholesterol, LDL; Creatinine; Enzyme Inhibitors; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipoproteinemia Type II; Male; Mevalonic Acid; Middle Aged; Pyrroles

Topics: Adolescent; Adult; Anticholesteremic Agents; Apolipoproteins B; Atorvastatin; Blood Component Removal; Cholesterol, LDL; Combined Modality Therapy; Enzyme Inhibitors; Female; Heptanoic Acids; Homozygote; Humans; Hyperlipoproteinemia Type II; Kinetics; Lipids; Lipoproteins, LDL; Male; Mevalonic Acid; Pyrroles

Topics: Anticholesteremic Agents; Atorvastatin; Bile Acids and Salts; Biomarkers; Cholestenones; Female; Heptanoic Acids; Heterozygote; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipoproteinemia Type II; Jejunoileal Bypass; Lipids; Lipoproteins; Male; Mevalonic Acid; Middle Aged; Pyrroles; Up-Regulation

Topics: Adolescent; Adult; Anticholesteremic Agents; Atorvastatin; Biomarkers; Child; Child, Preschool; Cholesterol; Cholesterol, LDL; DNA; DNA Mutational Analysis; Female; Heptanoic Acids; Homozygote; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipoproteinemia Type II; Male; Mevalonic Acid; Mutation; Polymorphism, Single-Stranded Conformational; Prognosis; Pyrroles; Receptors, LDL

Topics: Anticholesteremic Agents; Atorvastatin; Cholestenones; Cholesterol, LDL; Cholestyramine Resin; Colestipol; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl CoA Reductases; Hyperlipoproteinemia Type II; Male; Mevalonic Acid; Middle Aged; Mutation; Pyrroles; Receptors, LDL; RNA, Messenger

Topics: Adult; Anticholesteremic Agents; Atorvastatin; Dose-Response Relationship, Drug; Female; Gene Expression Regulation; Heptanoic Acids; Humans; Hyperlipoproteinemia Type II; Interleukin-10; Interleukin-12; Interleukin-12 Subunit p35; Leukocytes, Mononuclear; Lipids; Male; Mevalonic Acid; Middle Aged; Protein Subunits; Pyrroles; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Single-Blind Method

Topics: Adult; Antineoplastic Agents; Atorvastatin; Bezafibrate; Biomarkers; Carotid Artery Diseases; Carotid Artery, Common; Cholesterol, HDL; Cholesterol, LDL; Double-Blind Method; Endothelial Cells; Fas Ligand Protein; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemia, Familial Combined; Hypolipidemic Agents; Male; Membrane Glycoproteins; Mevalonic Acid; Middle Aged; Pyrroles; Terpenes; Time Factors; Treatment Outcome; Triglycerides; Tumor Necrosis Factor-alpha

Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosphate; Adsorption; Adult; Africa, Eastern; Aged; Air Pollutants; Air Pollution; Air Pollution, Indoor; Alcohol Drinking; Allergens; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Animals; Anti-Bacterial Agents; Antibodies; Antibodies, Immobilized; Antigen Presentation; Antigens, CD; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Apoptosis; Aptamers, Nucleotide; Asthma; Asthma, Exercise-Induced; Atrophy; Autophagy; Azoospermia; Bacillus cereus; Bacterial Infections; Beclin-1; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Biofouling; Biological Monitoring; Biomarkers; Biomarkers, Tumor; Biosensing Techniques; Blastocyst; Bone Neoplasms; Bone Regeneration; Bronchoconstriction; Burkitt Lymphoma; C9orf72 Protein; Campylobacter; Campylobacter Infections; Campylobacter jejuni; Carcinogenesis; Carcinoma, Hepatocellular; Carcinoma, Pancreatic Ductal; Carcinoma, Squamous Cell; Cardiomyopathies; Caregivers; Carmine; Case-Control Studies; Catalysis; Cattle; Cause of Death; CCAAT-Enhancer-Binding Protein-alpha; CD8-Positive T-Lymphocytes; Cefepime; Cell Differentiation; Cell Line, Tumor; Cell Nucleus; Cell Transdifferentiation; Chelating Agents; Chemical and Drug Induced Liver Injury, Chronic; Chemoradiotherapy, Adjuvant; Child; Child, Preschool; China; Chlorquinaldol; Cholangiocarcinoma; Cholera; Chromatin; Clinical Trials as Topic; Cognitive Dysfunction; Cohort Studies; Colonic Neoplasms; Colorectal Neoplasms; Colorimetry; Cooking; Coordination Complexes; COVID-19; Creatinine; CRISPR-Cas Systems; Critical Care; Critical Illness; Cross-Sectional Studies; Cryopreservation; Cryoprotective Agents; Cysteine; Cytokines; Device Removal; Diet; Diet, High-Fat; Diet, Mediterranean; Dietary Supplements; Dimethyl Sulfoxide; Dipeptides; Disease Models, Animal; Dithiothreitol; DNA; DNA Repeat Expansion; DNA, Bacterial; DNA, Complementary; Dopamine; Electrochemical Techniques; Electrodes; Endocannabinoids; Environmental Exposure; Environmental Monitoring; Environmental Pollutants; Enzyme-Linked Immunosorbent Assay; Erlotinib Hydrochloride; Escherichia coli; Escherichia coli O157; Esophageal Neoplasms; Esophagitis, Peptic; Ethylene Glycol; Europium; Exanthema; Fallopian Tubes; Feces; Female; Fertilization in Vitro; Fluoresceins; Fluorescent Dyes; Follicle Stimulating Hormone; Follow-Up Studies; Food Microbiology; Forced Expiratory Volume; Forkhead Transcription Factors; Frontotemporal Dementia; G-Quadruplexes; Galactose; Gastroenteritis; Gastrointestinal Diseases; Gastrointestinal Microbiome; Gastrointestinal Neoplasms; Gastrointestinal Tract; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Genital Neoplasms, Female; Genome-Wide Association Study; Genome, Viral; Genomics; Genotype; Glucose; Glutathione; Glycerol; Gold; Graphite; GTPase-Activating Proteins; Heat-Shock Proteins; Heme Oxygenase-1; Hepacivirus; Hepatitis C; Hepatocytes; Histamine; Histocompatibility Antigens Class II; Hoarseness; Hospice and Palliative Care Nursing; Humans; Hydrogen; Hydrogen Peroxide; Hydrogen Sulfide; Hydroxybenzoates; Hydroxyl Radical; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperthermia, Induced; Hysteroscopy; Immunoassay; Indigo Carmine; Inflammation; Inflammatory Bowel Diseases; Insulin Resistance; Intensive Care Units; Interleukin-11; Interleukin-6; Interleukins; Iodine Radioisotopes; Iran; Iridium; Islets of Langerhans; Kinetics; Lactation; Lactobacillus; Lactobacillus plantarum; Lamins; Latin America; Lead; Lectins; Leukopenia; Ligands; Limit of Detection; Lipopolysaccharides; Lipoprotein Lipase; Liver; Liver Cirrhosis; Liver Neoplasms; Lolium; Luminescent Measurements; Luminol; Lung; Luteinizing Hormone; Macrophages; Magnetic Phenomena; Magnetic Resonance Imaging; Male; Malnutrition; Maltose; Manganese Compounds; Maternal Nutritional Physiological Phenomena; Melatonin; Metabolic Engineering; Metal Nanoparticles; Metallocenes; Metaplasia; Methicillin-Resistant Staphylococcus aureus; Methylation; Mevalonic Acid; Mexico; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microbial Sensitivity Tests; Microbiota; MicroRNAs; Milk; Mitomycin; Molecular Diagnostic Techniques; Molecular Docking Simulation; Monte Carlo Method; Moringa oleifera; Multiple Sclerosis; Muscle Strength; Muscle, Skeletal; Nanocomposites; Nanotubes, Carbon; Neoadjuvant Therapy; Neoplasms; Neurodegenerative Diseases; Neurotransmitter Agents; NF-E2-Related Factor 2; Nickel; Nitrogen Dioxide; Non-alcoholic Fatty Liver Disease; Nucleic Acid Amplification Techniques; Nucleic Acid Hybridization; Nucleocapsid Proteins; Nutritional Status; Obesity; Osteogenesis; Osteosarcoma; Oxidation-Reduction; Oxides; Oxygen; Oxyquinoline; Pain; Palliative Care; Pancreatic Neoplasms; Pandemics; Particulate Matter; Peroxidase; Peroxidases; Phagocytosis; Phaseolus; Photothermal Therapy; Point-of-Care Systems; Polyethyleneimine; Polymers; Polymorphism, Single Nucleotide; Polysomnography; Postoperative Complications; Pregnancy; Pregnant Women; Prenatal Exposure Delayed Effects; Prevalence; Printing, Three-Dimensional; Probability; Probiotics; Prognosis; Prophages; Prospective Studies; Proteomics; Proto-Oncogene Proteins; Pseudomonas aeruginosa; Pseudomonas putida; Pulmonary Disease, Chronic Obstructive; Pulmonary Embolism; Pyridines; Pyrroles; Quality of Life; Quinolones; Rabbits; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Receptors, Histamine; Receptors, Histamine H2; Recombinases; Rectal Neoplasms; Reperfusion Injury; Respiration; Respiratory Function Tests; Respiratory Rate; Respiratory Sounds; Retrospective Studies; rho GTP-Binding Proteins; Risk Assessment; Risk Factors; RNA; RNA, Messenger; RNA, Ribosomal, 16S; Robotic Surgical Procedures; Running; Rural Population; Saccharomyces cerevisiae; Salpingectomy; Sarcopenia; SARS-CoV-2; Seeds; Semen; Sensitivity and Specificity; Sepsis; Shock, Septic; Signal Transduction; Silicon Dioxide; Silver; Sirtuin 1; Skin Neoplasms; Sleep Apnea, Obstructive; Soil; Spain; Spectrum Analysis, Raman; Sperm Retrieval; Spermatozoa; Spirometry; Staphylococcus aureus; STAT3 Transcription Factor; Stereoisomerism; Sterilization, Tubal; Stroke Volume; Sulfadiazine; Sulfites; Superoxide Dismutase; Surface Plasmon Resonance; tau Proteins; Testis; Testosterone; Thioredoxin-Disulfide Reductase; Thyroid Neoplasms; Thyroidectomy; Trans-Activators; Transcription Factor AP-1; Treatment Outcome; Triazoles; Triclosan; Trifluridine; Tumor Microenvironment; Tumor Necrosis Factor-alpha; United States; Uracil; Vagina; Vegetables; Ventricular Function, Left; Ventricular Pressure; Vibrio cholerae; Vietnam; Virulence; Vital Capacity; Vitrification; Walking; Water; Water Pollutants, Radioactive; Whole Genome Sequencing; Wind; YAP-Signaling Proteins; Zeolites; Zinc Oxide

Topics: Animals; Body Weight; Dose-Response Relationship, Drug; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Keratosis; Liver; Male; Mevalonic Acid; Necrosis; Neoplasms, Experimental; Organ Size; Pyrroles; Rats; Rats, Wistar; Stomach; Stomach Diseases

Topics: Acetates; Alkaloids; Animals; Anura; Carbon Isotopes; Cholesterol; Chromatography, Thin Layer; Mevalonic Acid; Pregnanes; Pyrroles; Quinolines; Skin; Toxins, Biological

Topics: Adult; Aged; Anticholesteremic Agents; Atorvastatin; Cholesterol; Coronary Disease; Enzyme Inhibitors; Female; Heptanoic Acids; Heterozygote; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipoproteinemia Type II; Lipids; Lipoproteins, LDL; Lovastatin; Male; Mevalonic Acid; Middle Aged; Pravastatin; Pyrroles; Simvastatin

Topics: Animals; Apoptosis; Atorvastatin; Cell Survival; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipids; Male; Mevalonic Acid; Muscle, Smooth, Vascular; Polyisoprenyl Phosphates; Protein Prenylation; Pyrroles; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Solubility

Topics: Animals; Anticholesteremic Agents; Aorta; Atorvastatin; Calcium; Cells, Cultured; Chelating Agents; Dose-Response Relationship, Drug; Drug Interactions; Fura-2; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Male; Mevalonic Acid; Muscle Contraction; Muscle, Smooth, Vascular; Phenylephrine; Pravastatin; Pyrroles; Rats; Rats, Sprague-Dawley; Simvastatin; Vasoconstrictor Agents

Topics: Animals; Atorvastatin; Chickens; Enzyme Inhibitors; Female; Fertility; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Insemination, Artificial; Lovastatin; Mevalonic Acid; Oviposition; Pyrroles; Simvastatin

Topics: Animals; Aorta, Thoracic; Atorvastatin; Base Sequence; Botulinum Toxins; DNA Primers; Endothelium, Vascular; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Male; Mevalonic Acid; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Phorbol 12,13-Dibutyrate; Pravastatin; Protein Kinase C; Pyridines; Pyrroles; Rats; Rats, Wistar; Superoxide Dismutase; Superoxides; Vasodilation

Topics: 3T3 Cells; Animals; Atorvastatin; Bacterial Proteins; Bacterial Toxins; Cytokines; Drug Interactions; Enzyme Induction; Gene Expression Regulation, Enzymologic; GTP-Binding Proteins; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Mice; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Polyisoprenyl Phosphates; Promoter Regions, Genetic; Pyrroles; rho GTP-Binding Proteins; Tumor Cells, Cultured

Topics: Adolescent; Adult; Anticholesteremic Agents; Apolipoproteins; Atorvastatin; Blood Component Removal; Female; Heptanoic Acids; Homozygote; Humans; Hyperlipoproteinemia Type II; Lipids; Lipoprotein(a); Lipoproteins; Lipoproteins, LDL; Lymphocytes; Male; Mevalonic Acid; Middle Aged; Pyrroles; Receptors, LDL

Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Atorvastatin; Caspase Inhibitors; Caspases; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activation; Flow Cytometry; Fluorescent Antibody Technique, Indirect; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid; Muscle, Smooth, Vascular; Polyisoprenyl Phosphates; Protein Prenylation; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Rabbits; Rats; rhoA GTP-Binding Protein; Sesquiterpenes; Simvastatin; Time Factors

Topics: Animals; Atorvastatin; Coronary Vessels; Endothelium, Vascular; Enzyme Activation; Glucose; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Mevalonic Acid; NADH, NADPH Oxidoreductases; NADPH Oxidases; Pyrroles; Superoxides; Swine

Topics: Atorvastatin; CD55 Antigens; Cell Line; Cells, Cultured; Complement Activation; Complement C3; Cytoprotection; Diterpenes; Endothelium, Vascular; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid; Nitric Oxide; Phosphatidylinositol 3-Kinases; Polyisoprenyl Phosphates; Protein Kinase C; Pyrroles; rho GTP-Binding Proteins; RNA, Messenger; Simvastatin; Up-Regulation

Topics: Atorvastatin; CD40 Antigens; CD40 Ligand; Cell Communication; Cell Line; Cells, Cultured; Cytokines; Endothelium, Vascular; Heptanoic Acids; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-12; Interleukin-12 Subunit p40; Jurkat Cells; Leukocytes; Mevalonic Acid; Monocytes; Protein Subunits; Pyrroles; Transcriptional Activation; Tumor Cells, Cultured; Umbilical Veins; Vascular Cell Adhesion Molecule-1

Topics: Animals; Apoptosis; Atorvastatin; CD4-Positive T-Lymphocytes; Cell Cycle; Cell Division; Cell Line; Encephalomyelitis, Autoimmune, Experimental; Female; Genes, MHC Class II; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid; Mice; Mice, Inbred Strains; Myelin Proteolipid Protein; Paralysis; Peptide Fragments; Pyrroles; Recurrence; Spinal Cord; Th1 Cells

Topics: ADP Ribose Transferases; Animals; Atorvastatin; Botulinum Toxins; Cells, Cultured; Cytotoxicity Tests, Immunologic; Enzyme Inhibitors; Fas Ligand Protein; Genes, Dominant; Heptanoic Acids; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ionophores; Jurkat Cells; Leukocytes, Mononuclear; Lymphocyte Activation; Membrane Glycoproteins; Mevalonic Acid; Mice; Phorbol Esters; Protein Prenylation; Pyrroles; rhoA GTP-Binding Protein; Simvastatin; T-Lymphocytes; Transfection

Topics: Animals; Arteriosclerosis; Atorvastatin; Blotting, Western; CD40 Antigens; Cells, Cultured; Depression, Chemical; Dose-Response Relationship, Drug; Endothelial Cells; Fibroblasts; Flow Cytometry; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; Interferon-gamma; Lovastatin; Macrophages; Mevalonic Acid; Mice; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Pravastatin; Pyrroles; Receptors, Cytoplasmic and Nuclear; Recombinant Proteins; Simvastatin; Transcription Factors

Topics: Amides; Atorvastatin; Cell Division; Cells, Cultured; Drug Interactions; Endothelium, Vascular; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intracellular Signaling Peptides and Proteins; Mevalonic Acid; Peptidyl-Dipeptidase A; Phosphorylation; Polyisoprenyl Phosphates; Protein Serine-Threonine Kinases; Pyridines; Pyrroles; rho-Associated Kinases; RNA, Messenger; Sesquiterpenes; Umbilical Veins; Up-Regulation; Vascular Endothelial Growth Factor A

Topics: Animals; Anticholesteremic Agents; Atorvastatin; Cell Movement; Chemokine CXCL12; Chemokines, CXC; Diterpenes; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Nonmammalian; Enzyme Inhibitors; Farnesol; gamma-Glutamyltransferase; Germ Cells; Heptanoic Acids; Hydroxymethylglutaryl CoA Reductases; Mevalonic Acid; Microinjections; Morpholines; Protein Prenylation; Pyrroles; RNA-Binding Proteins; RNA, Messenger; Somites; Time Factors; Zebrafish; Zebrafish Proteins

Topics: Animals; Atorvastatin; Cell Death; Cell Survival; Cholesterol; Dose-Response Relationship, Drug; Heptanoic Acids; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid; Neurites; Neurons; Polyisoprenyl Phosphates; Pyrroles; Rats; Sesquiterpenes; Squalene

Topics: Atorvastatin; Biological Assay; Calibration; Cell Line; Chromatography, Liquid; Enzyme Induction; Gene Expression Regulation, Enzymologic; Heptanoic Acids; Humans; Hydroxycholesterols; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mass Spectrometry; Mevalonic Acid; Pyrroles; Simvastatin

Topics: Alitretinoin; Animals; Atorvastatin; Base Sequence; Cell Line; Cholesterol; Consensus Sequence; DNA-Binding Proteins; Gene Expression Regulation; Hepatocytes; Heptanoic Acids; Homeostasis; Humans; Hydroxycholesterols; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver X Receptors; Lovastatin; Mevalonic Acid; Mice; Orphan Nuclear Receptors; Promoter Regions, Genetic; Proprotein Convertase 9; Proprotein Convertases; Pyridines; Pyrroles; Quinolines; Rats; Receptors, Cytoplasmic and Nuclear; Regulatory Sequences, Nucleic Acid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Alignment; Sequence Homology, Nucleic Acid; Serine Endopeptidases; Simvastatin; Sp1 Transcription Factor; Species Specificity; Sterol Regulatory Element Binding Protein 2; Transcription Factors; Tretinoin

Topics: Alkaline Phosphatase; Atorvastatin; Calcinosis; Dose-Response Relationship, Drug; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Mevalonic Acid; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Polyisoprenyl Phosphates; Pyridines; Pyrroles; Sesquiterpenes

Topics: 4-Chloro-7-nitrobenzofurazan; Alkyl and Aryl Transferases; Animals; Annexin A2; Atorvastatin; Azetidines; Boron Compounds; Caveolin 1; Caveolins; Cell Movement; Cholesterol; Diterpenes; DNA; Embryo, Nonmammalian; Ethylnitrosourea; Ezetimibe; Farnesol; Farnesyltranstransferase; Geranyltranstransferase; Germ Cells; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipid Metabolism; Lipids; Lovastatin; Mevalonic Acid; Microscopy, Fluorescence; Mutagenesis, Site-Directed; Mutation; Phosphatidylethanolamines; Protein Binding; Protein Prenylation; Pyrroles; Simvastatin; Zebrafish

Topics: Alkyl and Aryl Transferases; Aryldialkylphosphatase; Atorvastatin; Cell Line; Cell Nucleus; DNA; Dose-Response Relationship, Drug; Electrophoretic Mobility Shift Assay; Farnesyltranstransferase; Gene Expression Regulation, Enzymologic; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Luciferases; Mevalonic Acid; Plasmids; Polyisoprenyl Phosphates; Pyrroles; Quinolines; Sesquiterpenes; Sp1 Transcription Factor; Time Factors; Transcriptional Activation; Transfection

Topics: Animals; Apolipoprotein A-I; Atorvastatin; ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters; Cell Line; Cholesterol; Diterpenes; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression; Gene Expression Regulation; Genes, Dominant; Heptanoic Acids; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipid Metabolism; Lipoproteins; Macrophages; Mevalonic Acid; Mice; Models, Biological; Phosphorylation; Polyisoprenyl Phosphates; PPAR gamma; Pyrroles; rhoA GTP-Binding Protein; RNA, Messenger; Sesquiterpenes; Transfection; Up-Regulation

Topics: 3T3-L1 Cells; Animals; Atorvastatin; Cell Culture Techniques; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipoprotein Lipase; Mevalonic Acid; Mice; Pioglitazone; PPAR gamma; Pravastatin; Pyrroles; Quinolines; RNA, Messenger; Simvastatin; Thiazolidinediones

Topics: Adult; Atorvastatin; Cell Differentiation; Cells, Cultured; Dose-Response Relationship, Drug; Female; Glucocorticoids; Glycoproteins; Heptanoic Acids; Humans; Male; Mevalonic Acid; Models, Biological; Osteoblasts; Osteoprotegerin; Pyrroles; Receptors, Cytoplasmic and Nuclear; Receptors, Tumor Necrosis Factor; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors

Topics: Aged; Atherosclerosis; Atorvastatin; Carotid Artery Diseases; Cells, Cultured; Cyclooxygenase 2; Dinoprostone; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intracellular Signaling Peptides and Proteins; Intramolecular Oxidoreductases; Male; Matrix Metalloproteinase 1; Mevalonic Acid; Middle Aged; Monocytes; Prostaglandin-E Synthases; Protein Serine-Threonine Kinases; Pyrroles; Receptors, Prostaglandin E; rho GTP-Binding Proteins; rho-Associated Kinases

Topics: Atorvastatin; Cells, Cultured; Chemokine CCL2; Chemokine CXCL5; Chemokines, CXC; Endothelial Cells; Fibroblast Growth Factors; Granulocyte Colony-Stimulating Factor; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunologic Factors; Interleukin-6; Interleukin-8; Mevalonic Acid; Pyrroles

Topics: Adipose Tissue; Animal Feed; Animals; Atherosclerosis; Atorvastatin; Cholesterol; Gene Expression Regulation; Heptanoic Acids; Male; Mevalonic Acid; Plasminogen Activator Inhibitor 1; Pyrroles; Rabbits; RNA, Messenger; Triglycerides

Topics: Apoptosis; Atorvastatin; Cell Cycle; Cell Line, Transformed; Cells, Cultured; Endothelial Cells; Gene Expression Profiling; Gene Expression Regulation; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid; Oligonucleotide Array Sequence Analysis; Pyrroles; Simvastatin

Topics: Amino Acid Chloromethyl Ketones; Antibodies; Atorvastatin; Caspase 1; CD28 Antigens; CD3 Complex; Cells, Cultured; Enzyme Activation; Heptanoic Acids; Humans; Inflammation; Interferon-gamma; Interleukin-1; Interleukin-12; Interleukin-18; Mevalonic Acid; Mitosis; Monocytes; Pyrroles; Simvastatin; Solubility; T-Lymphocytes

Topics: Aged; Aorta; Atorvastatin; Carotid Artery Diseases; Cells, Cultured; Chemokine CCL2; Cytokine TWEAK; Cytokines; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation Mediators; Intracranial Arteriosclerosis; Male; Mevalonic Acid; Middle Aged; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Polyisoprenyl Phosphates; Pyrroles; Receptors, Tumor Necrosis Factor; Recombinant Proteins; rho GTP-Binding Proteins; Tumor Necrosis Factors; TWEAK Receptor; Up-Regulation

Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Atorvastatin; CD55 Antigens; CD59 Antigens; Cells, Cultured; Cobalt; Cytoprotection; Deferoxamine; Diterpenes; Endothelial Cells; Endothelium, Vascular; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoxia; Iron Chelating Agents; Mevalonic Acid; Pyrroles; RNA, Messenger; Up-Regulation

Topics: Antifungal Agents; Aspergillus fumigatus; Atorvastatin; Candida; Cholesterol; Ergosterol; Growth Inhibitors; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid; Pyrroles; Simvastatin

Topics: Atorvastatin; Chromatography, High Pressure Liquid; Heptanoic Acids; Herbicides; Hydroxymethylglutaryl CoA Reductases; Lovastatin; Mevalonic Acid; Models, Chemical; Pharmaceutical Preparations; Plants; Plastoquinone; Pyrroles; Risk Assessment; Sitosterols; Sterols; Ubiquinone; Ultraviolet Rays

Topics: Animals; Animals, Newborn; Apoptosis; Astrocytes; Atorvastatin; Cell Communication; Cell Differentiation; Cell Shape; Cell Survival; Cells, Cultured; Central Nervous System; Cholesterol; Coculture Techniques; Diterpenes; Dose-Response Relationship, Drug; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid; Neurons; Polyisoprenyl Phosphates; Pyrroles; Rats; Rats, Wistar; Receptors, LDL; Simvastatin; Up-Regulation

Topics: Angiotensin II; Animals; Atorvastatin; Cells, Cultured; Endothelin-1; Gene Expression Regulation; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mevalonic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oncogene Protein v-akt; Pyrroles; Rats; Rats, Sprague-Dawley; Up-Regulation

Topics: Adolescent; Adult; Aged; Atorvastatin; Cell Differentiation; Enzyme Induction; Gene Expression Regulation, Enzymologic; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Macrophages; Mevalonic Acid; Middle Aged; Peptidyl-Dipeptidase A; Phosphorylation; Polyisoprenyl Phosphates; Protein Kinase C; Pyrroles; RNA, Messenger; Sesquiterpenes; Terpenes; Up-Regulation

Topics: Alkyl and Aryl Transferases; Animals; Atorvastatin; Blotting, Western; Cattle; Dose-Response Relationship, Drug; Endothelium, Vascular; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipoproteins, HDL; Lysophospholipids; Mevalonic Acid; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphorylation; Pyrroles; Quinolines; Receptors, Lysosphingolipid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Sphingosine; Stimulation, Chemical

Topics: Animals; Atorvastatin; Cattle; Cell Division; Cell Movement; Cell Nucleus; Cells, Cultured; DNA; Drug Interactions; Extracellular Signal-Regulated MAP Kinases; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intracellular Signaling Peptides and Proteins; Kidney; Mevalonic Acid; Muscle, Smooth, Vascular; Polyisoprenyl Phosphates; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Pulmonary Artery; Pyrroles; rho-Associated Kinases; rhoA GTP-Binding Protein; Serotonin; Serotonin Agents; Serum Response Factor

Topics: Atorvastatin; C-Reactive Protein; CCAAT-Enhancer-Binding Proteins; Cells, Cultured; Fluorobenzenes; Hepatocytes; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunoassay; Interleukin-6; Mevalonic Acid; Pyrimidines; Pyrroles; RNA, Messenger; Rosuvastatin Calcium; STAT3 Transcription Factor; Sulfonamides; Transcription Factors

Topics: Adoptive Transfer; Animals; Antigen Presentation; Atorvastatin; Chemoprevention; Cytokines; Graft vs Host Disease; Graft vs Leukemia Effect; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid; Mice; Mice, Knockout; Premedication; Pyrroles; Signal Transduction; STAT6 Transcription Factor; T-Lymphocytes; Th2 Cells

Topics: Antioxidants; Atorvastatin; Bilirubin; Biliverdine; Cell Survival; Cells, Cultured; Cytoprotection; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Induction; Enzyme Inhibitors; Ferritins; Heme Oxygenase-1; Heptanoic Acids; Humans; Hydrogen Peroxide; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Iron Chelating Agents; Kruppel-Like Transcription Factors; Mevalonic Acid; Oxidants; Oxidative Stress; Prenylation; Promoter Regions, Genetic; Protoporphyrins; Pyrroles; Reactive Oxygen Species; RNA Interference; RNA, Messenger; RNA, Small Interfering; Terpenes

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; ADP Ribose Transferases; Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Atorvastatin; Benzamides; Botulinum Toxins; Cell Line, Tumor; Fas Ligand Protein; fas Receptor; Gene Expression Regulation, Neoplastic; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lymphocytes; Lymphoma; Melanoma, Experimental; Membrane Proteins; Methionine; Mevalonic Acid; Mice; Pyrroles; Recombinant Fusion Proteins; rho GTP-Binding Proteins; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA, Small Interfering

Topics: 5'-Nucleotidase; Adenosine Monophosphate; Adenosine Triphosphate; Atorvastatin; Cell Extracts; Cells, Cultured; Endothelial Cells; Extracellular Space; Heptanoic Acids; Humans; L-Lactate Dehydrogenase; Mevalonic Acid; Polyisoprenyl Phosphates; Pyrroles; Umbilical Veins

Topics: Animals; Anti-Inflammatory Agents; Anticholesteremic Agents; Atorvastatin; Carrageenan; Edema; Heptanoic Acids; Hindlimb; Inflammation; Male; Mevalonic Acid; Mice; Pyrroles; Rats; Rats, Wistar

Topics: Animals; Atorvastatin; Cell Proliferation; Diabetes Mellitus, Experimental; Down-Regulation; Endothelial Cells; Glucose; Heptanoic Acids; Humans; Kidney; Male; Mevalonic Acid; Oncogene Protein p21(ras); Oncogene Protein v-akt; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Prenylation; Pyrroles; Rats; Signal Transduction; Transforming Growth Factor beta1; Umbilical Veins

Topics: Animals; Atorvastatin; Calcitriol; Cholesterol Esters; Cholesterol, Dietary; Collagen; Gene Expression; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver; Liver Cirrhosis; Male; Mevalonic Acid; Mice; Mice, Inbred C57BL; Pyrroles; Transforming Growth Factor beta1; Triglycerides; Zymosan

Topics: Antigens, CD34; Atorvastatin; Blood Platelets; Blotting, Western; Calcium; Chromatography, High Pressure Liquid; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver; Mass Spectrometry; Megakaryocytes; Mevalonic Acid; Microscopy, Fluorescence; Organic Anion Transporters; Pyrroles; Reverse Transcriptase Polymerase Chain Reaction; RNA; Subcellular Fractions

Topics: Animals; Apoptosis; Atorvastatin; Cell Line, Tumor; Disulfides; Drug Screening Assays, Antitumor; Drug Synergism; Flow Cytometry; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Melanocytes; Melanoma, Experimental; Mevalonic Acid; Mice; Polyisoprenyl Phosphates; Pravastatin; Pyrroles; Sulfoxides; Terpenes

Topics: Antigens, CD; Arachidonic Acid; Atorvastatin; Cycloheximide; Cyclooxygenase 1; Cyclooxygenase 2; Dendritic Cells; Dinoprostone; Gene Expression; Half-Life; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kinetics; Mevalonic Acid; Peptidoglycan; Phospholipases A2, Cytosolic; Pyrroles; Zymosan

Topics: Atorvastatin; Celecoxib; Cell Cycle; Cell Division; Cell Line, Tumor; Chromans; Colonic Neoplasms; Cyclooxygenase 2 Inhibitors; Drug Synergism; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid; Polyisoprenyl Phosphates; Pyrazoles; Pyrroles; Sulfonamides; Vitamin E

Topics: ADP Ribose Transferases; Angiogenesis Inhibitors; Atorvastatin; Botulinum Toxins; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Down-Regulation; Endothelial Cells; Enzyme Inhibitors; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Matrix Metalloproteinase 9; Mevalonic Acid; Neovascularization, Physiologic; Nitrobenzenes; Polyisoprenyl Phosphates; Pyrroles; rho GTP-Binding Proteins; RNA, Messenger; Simvastatin; Sulfonamides; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha

Topics: Apoptosis; Atorvastatin; Cells, Cultured; Endothelial Cells; Enzyme Activation; Heptanoic Acids; Homocysteine; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid; NADPH Oxidase 4; NADPH Oxidases; Onium Compounds; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Pyrroles; Reactive Oxygen Species; Stem Cells

Topics: Animals; Anti-Inflammatory Agents; Antibodies, Blocking; Atorvastatin; Cell Line; Heptanoic Acids; Humans; Hypercholesterolemia; Lipopolysaccharides; Membrane Microdomains; Mevalonic Acid; Mice; Precursor Cells, B-Lymphoid; Protein Transport; Pyrroles; Receptor Aggregation; Toll-Like Receptor 4

Topics: Atorvastatin; Blood Platelets; Dose-Response Relationship, Drug; Fibrin; Fibrinolytic Agents; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid; P-Selectin; Perfusion; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Pravastatin; Pyrroles; Regional Blood Flow; Stress, Mechanical; Thrombin; Thromboplastin; Thrombosis; Time Factors; von Willebrand Factor

Topics: Animals; Anticholesteremic Agents; Atorvastatin; Cholesterol, Dietary; Choline; Choline Deficiency; Disease Models, Animal; Disease Susceptibility; Enzyme Inhibitors; Farnesyl-Diphosphate Farnesyltransferase; Fatty Liver; Glutathione; Heptanoic Acids; Lipotropic Agents; Liver; Male; Mevalonic Acid; Mice; Mice, Inbred C57BL; Mitochondria; Obesity; Pyrroles; Quinuclidines; Reperfusion Injury

Topics: Animals; Antigens, Bacterial; Arteritis; Atorvastatin; Cell Wall; Coronary Aneurysm; Coronary Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Induction; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunologic Factors; Lacticaseibacillus casei; Lymphocyte Activation; MAP Kinase Signaling System; Matrix Metalloproteinase 9; Mevalonic Acid; Mice; Mice, Inbred C57BL; Mucocutaneous Lymph Node Syndrome; Pyrroles; Specific Pathogen-Free Organisms; Superantigens; Tumor Necrosis Factor-alpha

Topics: Animals; Anticholesteremic Agents; Cholesterol, Dietary; Fatty Liver; Heptanoic Acids; Male; Mevalonic Acid; Pyrroles; Reperfusion Injury

Topics: Atorvastatin; Carcinoma, Hepatocellular; Computational Biology; Fatty Acids, Monounsaturated; Fluvastatin; Gene Expression Profiling; Gene Expression Regulation; Genome, Human; Hep G2 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Metabolic Networks and Pathways; Mevalonic Acid; Oligonucleotide Array Sequence Analysis; Pilot Projects; Principal Component Analysis; Pyrroles; Simvastatin

Topics: Active Transport, Cell Nucleus; Adipose Tissue; Animals; Atorvastatin; Cell Line; Cholesterol; Dexamethasone; Dose-Response Relationship, Drug; Drug Synergism; Fatty Acid-Binding Proteins; Glucocorticoids; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Macrophages; Male; Mevalonic Acid; Mice; Mice, Inbred C57BL; Promoter Regions, Genetic; Protein Prenylation; Pyrroles; Quinolines; Receptors, Glucocorticoid; Time Factors; Transfection; Up-Regulation

Topics: AMP-Activated Protein Kinases; Animals; Atorvastatin; Cells, Cultured; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipoprotein Lipase; Mevalonic Acid; Muscle, Skeletal; Pyrroles; Quinolines; Rats; Real-Time Polymerase Chain Reaction; RNA, Messenger

Topics: Actins; Amides; Animals; Aorta; Atorvastatin; Blotting, Western; Cell Line; Enzyme Inhibitors; Gene Expression Regulation; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Male; Mevalonic Acid; Mice; Mice, Inbred C57BL; Microfilament Proteins; Muscle Proteins; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nuclear Proteins; Polyisoprenyl Phosphates; Potassium Chloride; Pyridines; Pyrroles; Reverse Transcriptase Polymerase Chain Reaction; rho-Associated Kinases; rhoA GTP-Binding Protein; Trans-Activators; Vasoconstriction

Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Atorvastatin; Cell Proliferation; Croton Oil; Epidermal Cells; Epidermis; Female; Heptanoic Acids; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mevalonic Acid; Mice; Neovascularization, Pathologic; Pyrroles; Rats; Rats, Wistar; Skin Neoplasms

Topics: Animals; Atorvastatin; Base Sequence; Binding Sites; Blood Glucose; Cells, Cultured; Chromatin Immunoprecipitation; Cytoprotection; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Forkhead Box Protein O1; Forkhead Transcription Factors; Gene Expression Regulation; Heptanoic Acids; Human Umbilical Vein Endothelial Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kruppel-Like Transcription Factors; Male; Mevalonic Acid; Molecular Sequence Data; Nerve Tissue Proteins; Nitric Oxide Synthase Type III; Phosphorylation; Promoter Regions, Genetic; Pyrroles; Rats; Rats, Inbred OLETF; RNA Interference; Time Factors; Transfection; Vasodilation; Vasodilator Agents

Topics: Animals; Atorvastatin; Cell Line; Cell Survival; Gene Expression Regulation; Heptanoic Acids; Hydrogen Peroxide; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid; Mice; Myoblasts; Oxidative Stress; Pyridines; Pyrroles; Rats; Selenium; Selenoproteins

Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Atorvastatin; Cholesterol; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid; Neurons; Peptide Fragments; Phosphorylation; Pyrroles; Quinolines; Rats

Topics: Acetylcysteine; Acyl Coenzyme A; Animals; Antioxidants; Apoptosis; Atorvastatin; bcl-2-Associated X Protein; Caspase 3; Cell Line, Tumor; DNA Fragmentation; Extracellular Signal-Regulated MAP Kinases; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lymphoma; Membrane Potential, Mitochondrial; Mevalonic Acid; Mice; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Reactive Oxygen Species; Signal Transduction; Simvastatin

Topics: Antigens, CD; Atorvastatin; Cadherins; cdc42 GTP-Binding Protein; Guanosine Triphosphate; Heptanoic Acids; Human Umbilical Vein Endothelial Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intercellular Junctions; Interleukin-6; Interleukin-8; Lipopolysaccharides; Mevalonic Acid; Polyisoprenyl Phosphates; Prenylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Pyrroles; rho-Associated Kinases; Sesquiterpenes; Thrombin

Topics: Apoptosis; Atorvastatin; Caspase 3; Cell Line, Tumor; Cell Proliferation; Chromans; Drug Synergism; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Enzyme Activation; Heptanoic Acids; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mesothelioma; Metabolic Networks and Pathways; Mevalonic Acid; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Simvastatin; Vitamin E

Topics: Atorvastatin; Fatty Acids, Monounsaturated; Fluorobenzenes; Fluvastatin; Fungal Proteins; Heptanoic Acids; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Isoenzymes; Mevalonic Acid; Organisms, Genetically Modified; Pyrimidines; Pyrroles; Rosuvastatin Calcium; Saccharomyces cerevisiae; Simvastatin; Sterols; Sulfonamides; Terpenes

Topics: Animals; Anticholesteremic Agents; Atorvastatin; Bone Density Conservation Agents; Bone Neoplasms; cdc42 GTP-Binding Protein; Cell Line, Tumor; Diphosphonates; Female; Gene Expression Regulation, Neoplastic; Heptanoic Acids; Humans; Imidazoles; Intercellular Signaling Peptides and Proteins; L Cells; Lymphocyte Activation; MCF-7 Cells; Mevalonic Acid; Mice; Osteoblasts; Osteogenesis; Osteoprotegerin; Prenylation; Pyrroles; Rho Factor; RNA Interference; RNA, Small Interfering; Triple Negative Breast Neoplasms; Wnt3A Protein; Zoledronic Acid

Topics: Antigen Presentation; Atorvastatin; B-Lymphocytes; CD40 Antigens; Dendritic Cells; Gene Expression Regulation; Heptanoic Acids; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunity, Cellular; Lymphocyte Activation; Mevalonic Acid; Primary Cell Culture; Protein Prenylation; Pyrroles; Signal Transduction; Simvastatin; T-Lymphocytes; Transcriptome