Page last updated: 2024-08-18

pyrroles and marizomib

pyrroles has been researched along with marizomib in 114 studies

Research

Studies (114)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	54 (47.37)	29.6817
2010's	55 (48.25)	24.3611
2020's	5 (4.39)	2.80

Authors

Authors	Studies
Buchanan, GO; Feling, RH; Fenical, W; Jensen, PR; Kauffman, CA; Mincer, TJ	1
Corey, EJ; Reddy, LR; Saravanan, P	1
Fenical, W; Jensen, PR; Mincer, TJ; Williams, PG	1
Chao, TH; Deyanat-Yazdi, G; Fenical, WF; Jensen, PR; Lam, KS; Macherla, VR; Mai, B; Manam, RR; Mitchell, SS; Neuteboom, ST; Nicholson, B; Palladino, MA; Potts, BC; Reed, KA	1
Danishefsky, SJ; Endo, A	1
Corey, EJ; Fournier, JF; Reddy, BV; Reddy, LR	1
Corey, EJ; Fournier, JF; Reddy, LR; Subba Reddy, BV	1
Corey, EJ; Hogan, PC	1
Anderson, KC; Berkers, C; Catley, L; Chao, TH; Chauhan, D; Hideshima, T; Letai, A; Li, G; Mitsiades, C; Mitsiades, N; Neuteboom, ST; Nicholson, B; Ovaa, H; Palladino, MA; Podar, K; Richardson, P; Velankar, M; Yasui, H	1
Mulholland, NP; Pattenden, G; Walters, IA	2
Chandra, J; Keating, M; Krupnik, Y; McConkey, D; Palladino, M; Ruiz, S	1
Anderson, KC; Chauhan, D; Hideshima, T	1
Bernasconi, P; Calatroni, S; Crosetto, N; Dikic, I	1
Chao, TH; Cusack, JC; Liu, R; Neuteboom, ST; Niu, W; Palladino, MA; Palombella, VJ; Pien, C; Xia, L	1
Blank, JL; Bruzzese, FJ; Cao, Y; Daniels, JS; Dick, LR; Labutti, J; Mazzola, AM; Patil, AD; Reimer, CL; Rolfe, M; Solomon, MS; Stirling, M; Tian, Y; Tsu, CA; Weatherhead, GS; Williamson, MJ; Zhang, JX	1
Chao, TH; Deyanat-Yazdi, G; Lam, KS; Manam, RR; Mitchell, SS; Neuteboom, ST; Potts, BC; Reed, KA; Teisan, S; Xu, J	1
Bacon, KB; Benet-Buchholz, J; Bitzer, J; Gantner, F; Mayer-Bartschmid, A; Müller, H; Reinemer, P; Stadler, M; Tichy, HV	1
Beer, LL; Moore, BS	1
Lam, KS; McArthur, KA; Potts, BC; Tsueng, G	1
Ban, K; Chandra, J; Dujka, ME; McConkey, DJ; Miller, CP; Munsell, M; Palladino, M	1
Lam, KS; McArthur, KA; Mitchell, SS; Potts, BC; Tsueng, G; Xu, J	1
Fukuda, N; Kanai, M; Shibasaki, M	1
Ma, G; Nguyen, H; Romo, D	2
Ling, T; Macherla, VR; Manam, RR; McArthur, KA; Potts, BC	1
Denora, N; Potts, BC; Stella, VJ	1
Aggarwal, BB; Ahn, KS; Chao, TH; Chaturvedi, MM; Neuteboom, ST; Palladino, MA; Sethi, G; Younes, A	1
Lam, KS; Tsueng, G	3
Anderson, KC; Brahmandam, M; Chauhan, D; Hideshima, T; Munshi, N; Palladino, MA; Podar, K; Richardson, P; Singh, A	1
Eustáquio, AS; Moore, BS; Noel, JP; Pojer, F	1
Lam, KS; Teisan, S; Tsueng, G	1
Anderson, KC; Azab, A; Azab, F; Burwick, N; Chauhan, D; Farag, M; Ghobrial, IM; Hideshima, T; Jia, X; Leleu, X; Melhem, M; Moreau, AS; Ngo, HT; Palladino, MA; Roccaro, AM; Runnels, J; Sacco, A; Treon, SP	1
Eustáquio, AS; Moore, BS	1
Baritaki, S; Berenson, J; Bonavida, B; Daniels, TR; Jazirehi, AR; Palladino, M; Penichet, ML; Spandidos, DA; Suzuki, E; Umezawa, K	1
Asolkar, RN; Eustáquio, AS; Fenical, W; McGlinchey, RP; Moore, BS; Nett, M	1
Bertani, S; Fenical, W; Jensen, P; Le Roch, K; McDaniel, E; Ponts, N; Prudhomme, J	1
Hatakeyama, S; Ishihara, J; Kawano, K; Midori, M; Takahashi, K	1
Cusack, JC; Houston, M; Liu, R; Ljungman, D; Palladino, MA; Sloss, CM; Wang, F; Xia, L	1
Arima, S; Fukuda, T; Harigaya, Y; Nagamitsu, T; Omura, S; Sugiyama, K	1
Fenical, W; Jensen, PR; Lam, KS; Lloyd, GK; Palladino, MA; Potts, BC	1
Dring, CW; Lam, KS; Macherla, VR; Manam, RR; Neuteboom, ST; Potts, BC; Tsueng, G; Weiss, J	1
Chandra, J; Keating, MJ; Miller, CP; Palladino, M; Rudra, S; Wierda, WG	1
Sing Lam, K; Tsueng, G	1
Chan, W; Heymach, J; McConkey, DJ; Wilkinson, M; Zhu, K	1
Fuchs, O; Kuzelova, K; Marinov, I; Provaznikova, D; Spicka, I	1
Tsukamoto, S; Yokosawa, H	1
Alhamadsheh, MM; Beer, LL; Eustáquio, AS; Florova, G; Hazzard, C; Kale, AJ; Kobayashi, Y; Lechner, A; Liu, Y; McGlinchey, RP; Moore, BS; Reynolds, KA	1
Baritaki, S; Bonavida, B; Chapman, A; Palladino, M; Spandidos, DA; Yeung, K	1
Baerga-Ortiz, A	1
Orlowski, RZ; Shah, JJ	1
Gulder, TA; Hughes, CC; Kale, AJ; Moore, BS; Nett, M	1
Baritaki, S; Berenson, J; Bonavida, B; Palladino, M; Yeung, K	1
Dunner, K; McConkey, DJ; Zhu, K	1
Anderson, KC; Chauhan, D; Ciccarelli, B; Palladino, MA; Richardson, PG; Singh, AV	1
Anderson, KC; Chauhan, D; Lloyd, GK; Palladino, MA; Potts, BC; Singh, AV	1
Ling, T; Macherla, VR; Potts, BC	1
Lam, KS; Potts, BC	1
Vollmar, AM; von Schwarzenberg, K	1
Gulder, TA; Moore, BS	1
Fremgen, T; Gladysheva, T; Ma, G; Nguyen, H; Romo, D	1
Chida, N; Hasegawa, J; Kaiya, Y; Momose, T; Sato, T	1
Albitar, MX; Anderson, KC; Baritaki, S; Berkers, C; Bonavida, B; Chandra, J; Chauhan, D; Cusack, JC; Fenical, W; Ghobrial, IM; Groll, M; Jensen, PR; Lam, KS; Lloyd, GK; McBride, W; McConkey, DJ; Miller, CP; Neuteboom, ST; Oki, Y; Ovaa, H; Pajonk, F; Palladino, MA; Potts, BC; Richardson, PG; Roccaro, AM; Sloss, CM; Spear, MA; Valashi, E; Younes, A	1
Chao, TH; Enna, SJ; Hagenbuch, B; Lloyd, GK; Macherla, VR; Manam, RR; McArthur, K; Neuteboom, ST; Obaidat, A; Palladino, MA; Potts, BC; Wahlgren, B; Weiss, J	1
Bitzer, J; Herrmann, J; Huo, L; Köpcke, B; Müller, R; Rachid, S; Stadler, M	1
Goldschmidt, H; Moehler, T	1
Fukuyama, T; Satoh, N; Yokoshima, S	1
Kay, LE; Ruschak, AM; Schimmer, AD; Slassi, M	1
Deska, J; Hähn, S; Kazmaier, U	1
Liu, Z; Ma, Y; Qu, L; Yang, Z; Zhang, L	1
Chandra, J; Debose, L; Hale, R; Macherla, VR; Manton, CA; Miller, CP; Palladino, MA; Potts, BC	1
Kale, AJ; Lechner, A; McGlinchey, RP; Moore, BS	1
Palladino, MA; Potts, BC; Steverding, D; Wang, X	1
Drabkin, HA; Gemmill, RM; Lay, A; Lee, L; Lloyd, GK; Longenecker, A; McConkey, DJ; Millward, M; Neuteboom, ST; Palladino, MA; Price, T; Sharma, G; Spear, MA; Spencer, A; Sukumaran, S; Sweeney, C; Townsend, A	1
Eustáquio, AS; Gulder, TA; Hafner, M; Lechner, A; Moore, BS	1
Gallastegui, N; Groll, M	1
Abe, M; Fujii, S	1
Hu, Y; Wu, P; Zhang, J	1
Mateos, MV; Ocio, EM; San Miguel, JF	1
Blasdel, LK; Lee, D; Myers, AG; Sun, B	1
Anderl, JL; Assaraf, YG; Cloos, J; Jansen, G; Kale, AJ; Kaspers, GJ; Moore, BS; Niewerth, D; Riethoff, LF; van Meerloo, J; Zweegman, S	1
Burton, JW; Foster, RW; Garzya, V; Hallside, MS; Logan, AW; Marx, LB; Sprague, SJ; Thompson, AL	1
Kuroda, J	1
Diao, A; Ma, L	1
Chandra, J; Corrales-Medina, FF; Manton, CA; Orlowski, RZ	1
Anderson, KC; Chauhan, D; Das, DS; Ray, A; Richardson, P; Song, Y; Trikha, M	1
Abraham, V; Bota, DA; Burrows, FJ; Desjardins, A; Di, K; Lloyd, GK; MacLaren, A; Trikha, M	1
Bailey, CP; Bouchier-Hayes, L; Chandra, J; Johnson, B; Manton, CA; Singh, M	1
Guo, L; Qu, G; Wu, C; Xie, Z; Yang, X; Zhang, S; Zhou, L	1
Anderson, KC; Chanan-Khan, AA; Chauhan, D; Hofmeister, CC; Jakubowiak, AJ; Kaufman, JL; Laubach, JP; Reich, S; Richardson, PG; Talpaz, M; Trikha, M; Zimmerman, TM	1
Cannell, PK; Harrison, SJ; Mainwaring, P; Millward, MJ; Padrik, P; Price, T; Reich, SD; Spencer, A; Trikha, M; Underhill, CR	1
Anderson, KC; Burrows, FJ; Chauhan, D; Harrison, SJ; Levin, N; Reich, SD; Richardson, PG; Spencer, A; Trikha, M	1
Kłoczko, J; Ołdziej, AE; Romaniuk, W; Zińczuk, J	1
Moreau, P; Rajkumar, SV	1
Fielding, E; Groenhagen, U; Leandrini De Oliveira, AL; Moore, BS; Schulz, S	1
Bocchia, M; Brambilla, CZ; Candi, V; Gozzetti, A; Papini, G; Sirianni, S	1
Dineshkumar, K; Hopper, W; Vasudevan, A	1
Badros, A; Dhakal, B; Hari, P; Kwok, Y; MacLaren, A; Richardson, P; Singh, Z; Trikha, M	1
Ma, H; Su, Z; Sun, F; Zhao, N	1
Bullova, P; Cougnoux, A; Kopacek, J; Marzouca, G; Pacak, K	1
Burton, JW; Marx, LB	1
Grammatico, S; Petrucci, MT; Scalzulli, E; Vozella, F	1
Groll, M; Nguyen, H; Romo, D; Vellalath, S	1
Borhan, B; Favor, OK; Gholami, H; Kulshrestha, A; Staples, RJ	1
Badodi, S; Benjamin-Ombo, VA; Frisira, E; Michod, D; Niklison-Chirou, MV; Rashid, F; Varma, SN	1
Andreasson, KI; Ceribelli, M; Chen, L; Duveau, DY; Ferrer, M; Geraghty, AC; Ghanem, R; Gillespie, SM; Guha, R; Itkin, Z; Klumpp-Thomas, C; Kreimer, S; Lennon, J; Lin, GL; McKnight, C; Michael, S; Michalowski, AM; Minhas, P; Monje, M; Morris, PJ; Nagaraja, S; Ni, L; Qin, EY; Quezada, M; Raabe, EH; Shinn, P; Stanton, BZ; Thomas, CJ; Vitanza, NA; Warren, KE; Wilson, KM; Woo, PJ; Zhang, X	1
Agarwal, P; Krishna, M; Lang, M; Liao, PJ; Linehan, WM; Matsumoto, S; Mitchell, JB; Neckers, L; Railkar, R; Ricketts, CJ; Sourbier, C; Trepel, JB; Wei, D; Wei, MH; Yang, Y	1
Li, J; Sherman, DJ	1
Datta, KK; Dong, LF; Dutt, M; Gowda, H; Hill, M; Kalimutho, M; Kalita-de Croft, P; Khanna, KK; Lee, A; Lu, X; Neuzil, J; Pouliot, N; Raninga, PV; Sinha, D	1
Mason, WP; Richardson, PG; Roth, P; Weller, M	1
Jeong, GS; Lee, HS	1
Boccellato, C; Fullstone, G; Idbaih, A; Juric, V; Kolbe, E; Lamfers, MLM; Murphy, BM; Peters, N; Rehm, M; Verreault, M	1

Reviews

24 review(s) available for pyrroles and marizomib

Article	Year
Marine actinomycete diversity and natural product discovery. Antonie van Leeuwenhoek, 2005, Volume: 87, Issue:1 Topics: Actinobacteria; Antibiotics, Antineoplastic; Biodiversity; Biological Factors; Geologic Sediments; Lactones; Pyrroles; Seawater	2005
A novel proteasome inhibitor NPI-0052 as an anticancer therapy. British journal of cancer, 2006, Oct-23, Volume: 95, Issue:8 Topics: Animals; Antineoplastic Agents; Apoptosis; Humans; Lactones; Models, Biological; Molecular Structure; Multiple Myeloma; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrroles; Xenograft Model Antitumor Assays	2006
Targeting ubiquitin in cancers. European journal of cancer (Oxford, England : 1990), 2006, Volume: 42, Issue:18 Topics: Antineoplastic Agents; Boronic Acids; Bortezomib; Cell Communication; Cell Cycle; Genetic Therapy; Heat-Shock Proteins; Humans; Lactones; Neoplasms; Pyrazines; Pyrroles; Ubiquitin	2006
Total synthesis of lactacystin and salinosporamide A. Chemistry, an Asian journal, 2007, Jan-08, Volume: 2, Issue:1 Topics: Acetylcysteine; Enzyme Inhibitors; Lactones; Molecular Structure; Proteasome Inhibitors; Pyrroles; Stereoisomerism	2007
Antiproliferative and proapoptotic effects of proteasome inhibitors and their combination with histone deacetylase inhibitors on leukemia cells. Cardiovascular & hematological disorders drug targets, 2009, Volume: 9, Issue:1 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Boronic Acids; Bortezomib; Cell Line, Tumor; Cell Proliferation; Drug Synergism; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Humans; Lactones; Leukemia; Oligopeptides; Protease Inhibitors; Pyrazines; Pyrroles	2009
Targeting the proteasome pathway. Expert opinion on therapeutic targets, 2009, Volume: 13, Issue:5 Topics: Acetylcysteine; Animals; Antineoplastic Agents; Biological Products; Boronic Acids; Bortezomib; Drug Delivery Systems; Drug Discovery; Humans; Lactones; Neoplasms; Peptides; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Pyrroles; Structure-Activity Relationship; Ubiquitin; Ubiquitin-Activating Enzymes; Ubiquitins	2009
Biotechnology and biochemistry of marine natural products. Puerto Rico health sciences journal, 2009, Volume: 28, Issue:3 Topics: Actinobacteria; Biochemistry; Biological Products; Biotechnology; Bryostatins; Fatty Acids, Omega-3; Lactones; Marine Biology; Pyrroles	2009
Proteasome inhibitors in the treatment of multiple myeloma. Leukemia, 2009, Volume: 23, Issue:11 Topics: Antineoplastic Agents; Boronic Acids; Bortezomib; Humans; Lactones; Multiple Myeloma; Oligopeptides; Protease Inhibitors; Pyrazines; Pyrroles	2009
Generating a generation of proteasome inhibitors: from microbial fermentation to total synthesis of salinosporamide a (marizomib) and other salinosporamides. Marine drugs, 2010, Mar-25, Volume: 8, Issue:4 Topics: Animals; Drug Design; Enzyme Inhibitors; Fermentation; Humans; Lactones; Neoplasms; Proteasome Inhibitors; Pyrroles; Technology, Pharmaceutical	2010
Targeting apoptosis pathways by natural compounds in cancer: marine compounds as lead structures and chemical tools for cancer therapy. Cancer letters, 2013, May-28, Volume: 332, Issue:2 Topics: Alkaloids; Alkanes; Animals; Anti-Bacterial Agents; Antineoplastic Agents; Apoptosis; Aquatic Organisms; Biological Products; Bryostatins; Carbamates; Cell Proliferation; Depsipeptides; Dioxoles; Drug Screening Assays, Antitumor; Humans; Lactones; Macrolides; Microtubules; Models, Chemical; Neoplasms; Phenanthrolines; Phenazines; Proteasome Endopeptidase Complex; Pyrones; Pyrroles; Quinolines; Spiro Compounds; Steroids; Tetrahydroisoquinolines; Thiazoles; Trabectedin	2013
Salinosporamide natural products: Potent 20 S proteasome inhibitors as promising cancer chemotherapeutics. Angewandte Chemie (International ed. in English), 2010, Dec-03, Volume: 49, Issue:49 Topics: Antineoplastic Combined Chemotherapy Protocols; Biological Factors; Cysteine Proteinase Inhibitors; Humans; Lactones; Molecular Conformation; Neoplasms; Proteasome Inhibitors; Pyrroles	2010
Marizomib, a proteasome inhibitor for all seasons: preclinical profile and a framework for clinical trials. Current cancer drug targets, 2011, Volume: 11, Issue:3 Topics: Animals; Antineoplastic Agents; Drug Evaluation, Preclinical; Humans; Lactones; Neoplasms; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrroles	2011
Therapy of relapsed and refractory multiple myeloma. Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 2011, Volume: 183 Topics: Adrenal Cortex Hormones; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Dexamethasone; Hematopoietic Stem Cell Transplantation; Humans; Lactones; Lenalidomide; Middle Aged; Multiple Myeloma; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Pyrroles; Secondary Prevention; Thalidomide	2011
Novel proteasome inhibitors to overcome bortezomib resistance. Journal of the National Cancer Institute, 2011, Jul-06, Volume: 103, Issue:13 Topics: Allosteric Site; Animals; Antineoplastic Agents; Apoptosis; Boronic Acids; Bortezomib; Cell Line, Tumor; Chloroquine; Clioquinol; Drug Resistance, Neoplasm; Humans; Hydroxyquinolines; Lactones; Neoplasms; Oligopeptides; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Pyrroles; Threonine; Ubiquitinated Proteins; Ubiquitination	2011
Synthesis of salinosporamide A and its analogs as 20S proteasome inhibitors and SAR summarization. Current topics in medicinal chemistry, 2011, Volume: 11, Issue:23 Topics: Lactones; Protease Inhibitors; Proteasome Inhibitors; Pyrroles; Structure-Activity Relationship	2011
Clinical and marketed proteasome inhibitors for cancer treatment. Current medicinal chemistry, 2013, Volume: 20, Issue:20 Topics: Boron Compounds; Boronic Acids; Bortezomib; Glycine; Humans; Lactones; Neoplasms; Oligopeptides; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Pyrroles; Structure-Activity Relationship; Threonine	2013
Novel generation of agents with proven clinical activity in multiple myeloma. Seminars in oncology, 2013, Volume: 40, Issue:5 Topics: Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Humans; Immunologic Factors; Lactones; Multiple Myeloma; Oligopeptides; Proteasome Inhibitors; Pyrroles; Recurrence; Thalidomide; Treatment Outcome	2013
[Current status of clinical trials of novel agents for multiple myeloma]. [Rinsho ketsueki] The Japanese journal of clinical hematology, 2014, Volume: 55, Issue:10 Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Drug Approval; Drug Discovery; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Lactones; Molecular Targeted Therapy; Multiple Myeloma; Oligopeptides; Pyrroles; Thalidomide; Vorinostat	2014
Marizomib, a potent second generation proteasome inhibitor from natural origin. Anti-cancer agents in medicinal chemistry, 2015, Volume: 15, Issue:3 Topics: Actinobacteria; Antineoplastic Agents; Biological Products; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Lactones; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrroles; Structure-Activity Relationship	2015
[Proteasome inhibitors in cancer therapy]. Postepy higieny i medycyny doswiadczalnej (Online), 2015, Dec-31, Volume: 69 Topics: Antineoplastic Agents; Apoptosis; Boronic Acids; Bortezomib; Caspases; Dipeptides; Humans; Lactones; Multiple Myeloma; Neoplasms; Oligopeptides; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Proteolysis; Pyrroles; Thiazoles; Threonine	2015
Second Generation Proteasome Inhibitors in Multiple Myeloma. Anti-cancer agents in medicinal chemistry, 2017, Volume: 17, Issue:7 Topics: Animals; Boronic Acids; Bortezomib; Central Nervous System Neoplasms; Drug Discovery; Humans; Lactones; Multiple Myeloma; Neoplasm Recurrence, Local; Oligopeptides; Proteasome Inhibitors; Pyrroles; Threonine	2017
Proteasome inhibitors for the treatment of multiple myeloma. Expert opinion on pharmacotherapy, 2018, Volume: 19, Issue:4 Topics: Antibodies, Monoclonal; Antineoplastic Agents; Boron Compounds; Bortezomib; Glycine; Hematologic Diseases; Humans; Lactones; Multiple Myeloma; Neoplasm Recurrence, Local; Oligopeptides; Proteasome Inhibitors; Pyrroles	2018
Proteasome Inhibitors: Harnessing Proteostasis to Combat Disease. Molecules (Basel, Switzerland), 2020, Feb-05, Volume: 25, Issue:3 Topics: Antineoplastic Agents; Boron Compounds; Bortezomib; Glycine; Humans; Lactones; Molecular Targeted Therapy; Multiple Myeloma; Oligopeptides; Proteasome Inhibitors; Proteostasis; Pyrroles	2020
Proteasome inhibition for the treatment of glioblastoma. Expert opinion on investigational drugs, 2020, Volume: 29, Issue:10 Topics: Animals; Antineoplastic Agents; Bortezomib; Brain Neoplasms; Drug Development; Glioblastoma; Humans; Lactones; Proteasome Inhibitors; Pyrroles	2020

Trials

4 trial(s) available for pyrroles and marizomib

Article	Year
Phase 1 clinical trial of the novel proteasome inhibitor marizomib with the histone deacetylase inhibitor vorinostat in patients with melanoma, pancreatic and lung cancer based on in vitro assessments of the combination. Investigational new drugs, 2012, Volume: 30, Issue:6 Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Drug Combinations; Female; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Lactones; Lung Neoplasms; Male; Melanoma; Middle Aged; Pancreatic Neoplasms; Proteasome Inhibitors; Pyrroles; Vorinostat	2012
Phase 1 study of marizomib in relapsed or relapsed and refractory multiple myeloma: NPI-0052-101 Part 1. Blood, 2016, 06-02, Volume: 127, Issue:22 Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Dexamethasone; Female; Humans; Lactones; Male; Maximum Tolerated Dose; Middle Aged; Multiple Myeloma; Pyrroles; Recurrence; Thalidomide	2016
Phase I Clinical Trial of Marizomib (NPI-0052) in Patients with Advanced Malignancies Including Multiple Myeloma: Study NPI-0052-102 Final Results. Clinical cancer research : an official journal of the American Association for Cancer Research, 2016, Sep-15, Volume: 22, Issue:18 Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Drug Administration Schedule; Female; Humans; Lactones; Male; Middle Aged; Multiple Myeloma; Neoplasm Staging; Neoplasms; Proteasome Inhibitors; Pyrroles; Recurrence; Retreatment; Treatment Outcome; Young Adult	2016
Marizomib irreversibly inhibits proteasome to overcome compensatory hyperactivation in multiple myeloma and solid tumour patients. British journal of haematology, 2016, Volume: 174, Issue:5 Topics: Caspases; Chymotrypsin; Enzyme Activation; Glioma; Humans; Lactones; Multiple Myeloma; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrroles; Trypsin	2016

Other Studies

86 other study(ies) available for pyrroles and marizomib

Article	Year
Salinosporamide A: a highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus salinospora. Angewandte Chemie (International ed. in English), 2003, Jan-20, Volume: 42, Issue:3 Topics: Actinomycetales; Adenocarcinoma; Colonic Neoplasms; Crystallography, X-Ray; Cysteine Endopeptidases; Humans; Inhibitory Concentration 50; Lactones; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Structure; Multienzyme Complexes; Protease Inhibitors; Proteasome Endopeptidase Complex; Pyrroles; Tumor Cells, Cultured	2003
A simple stereocontrolled synthesis of salinosporamide A. Journal of the American Chemical Society, 2004, May-26, Volume: 126, Issue:20 Topics: Antineoplastic Agents; Indicators and Reagents; Lactones; Magnetic Resonance Spectroscopy; Optical Rotation; Pyrroles; Spectrophotometry, Infrared; Stereoisomerism	2004
Structure-activity relationship studies of salinosporamide A (NPI-0052), a novel marine derived proteasome inhibitor. Journal of medicinal chemistry, 2005, Jun-02, Volume: 48, Issue:11 Topics: Actinobacteria; Animals; Antineoplastic Agents; Cell Line; Cell Line, Tumor; Humans; Lactones; Marine Biology; NF-kappa B; Proteasome Inhibitors; Pyrroles; Rabbits; Stereoisomerism; Structure-Activity Relationship	2005
Total synthesis of salinosporamide A. Journal of the American Chemical Society, 2005, Jun-15, Volume: 127, Issue:23 Topics: Actinomycetales; Lactones; Protease Inhibitors; Pyrroles; Selenium; Stereoisomerism	2005
New synthetic route for the enantioselective total synthesis of salinosporamide A and biologically active analogues. Organic letters, 2005, Jun-23, Volume: 7, Issue:13 Topics: Catalysis; Cyclization; Lactones; Molecular Structure; Pyrroles; Stereoisomerism	2005
An efficient, stereocontrolled synthesis of a potent omuralide-salinosporin hybrid for selective proteasome inhibition. Journal of the American Chemical Society, 2005, Jun-29, Volume: 127, Issue:25 Topics: Enzyme Inhibitors; Lactones; Molecular Conformation; Proteasome Inhibitors; Pyrroles; Stereoisomerism	2005
Proteasome inhibition by a totally synthetic beta-lactam related to salinosporamide A and omuralide. Journal of the American Chemical Society, 2005, Nov-09, Volume: 127, Issue:44 Topics: beta-Lactams; Drug Stability; Half-Life; Kinetics; Lactones; Proteasome Inhibitors; Pyrroles	2005
A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib. Cancer cell, 2005, Volume: 8, Issue:5 Topics: Administration, Oral; Animals; Antineoplastic Agents; Apoptosis; Boronic Acids; Bortezomib; Caspases; Cell Movement; Cell Proliferation; Drug Synergism; Genes, bcl-2; Humans; Lactones; Lymphocytes; Mice; Mitochondria; Multiple Myeloma; NF-kappa B; Plasmacytoma; Protease Inhibitors; Proteasome Endopeptidase Complex; Pyrazines; Pyrroles; Tumor Cells, Cultured	2005
A concise total synthesis of salinosporamide A. Organic & biomolecular chemistry, 2006, Aug-07, Volume: 4, Issue:15 Topics: Cyclization; Lactones; Protease Inhibitors; Proteasome Inhibitors; Pyrroles	2006
The proteasome inhibitor NPI-0052 is a more effective inducer of apoptosis than bortezomib in lymphocytes from patients with chronic lymphocytic leukemia. Molecular cancer therapeutics, 2006, Volume: 5, Issue:7 Topics: Antineoplastic Agents; Apoptosis; Boronic Acids; Bortezomib; Humans; Lactones; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphocytes; Protease Inhibitors; Proteasome Inhibitors; Pyrazines; Pyrroles	2006
NPI-0052 enhances tumoricidal response to conventional cancer therapy in a colon cancer model. Clinical cancer research : an official journal of the American Association for Cancer Research, 2006, Nov-15, Volume: 12, Issue:22 Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Boronic Acids; Bortezomib; Cell Cycle; Colonic Neoplasms; Drug Administration Routes; Drug Synergism; Female; Humans; Lactones; Mice; Mice, Nude; NF-kappa B; Proteasome Endopeptidase Complex; Pyrazines; Pyrroles; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Xenograft Model Antitumor Assays	2006
Comparison of biochemical and biological effects of ML858 (salinosporamide A) and bortezomib. Molecular cancer therapeutics, 2006, Volume: 5, Issue:12 Topics: Animals; Antineoplastic Agents; Binding, Competitive; Boronic Acids; Bortezomib; Drug Stability; Female; HeLa Cells; HT29 Cells; Humans; Lactones; Mice; Mice, Nude; Mice, SCID; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Pyrroles; Xenograft Model Antitumor Assays	2006
Salinosporamides D-J from the marine actinomycete Salinispora tropica, bromosalinosporamide, and thioester derivatives are potent inhibitors of the 20S proteasome. Journal of natural products, 2007, Volume: 70, Issue:2 Topics: Actinobacteria; Bahamas; Crystallography, X-Ray; Inhibitory Concentration 50; Lactones; Marine Biology; Molecular Conformation; Molecular Structure; Proteasome Inhibitors; Pyrroles	2007
Cinnabaramides A-G: analogues of lactacystin and salinosporamide from a terrestrial streptomycete. Journal of natural products, 2007, Volume: 70, Issue:2 Topics: Acetylcysteine; Crystallography, X-Ray; Humans; Lactones; Molecular Conformation; Molecular Structure; Proteasome Inhibitors; Pyrroles; Streptomyces	2007
Biosynthetic convergence of salinosporamides A and B in the marine actinomycete Salinispora tropica. Organic letters, 2007, Mar-01, Volume: 9, Issue:5 Topics: Amino Acids; Lactams; Lactones; Magnetic Resonance Spectroscopy; Micromonosporaceae; Molecular Structure; Oceans and Seas; Peptides; Pyrroles	2007
Unique butyric acid incorporation patterns for salinosporamides A and B reveal distinct biosynthetic origins. Applied microbiology and biotechnology, 2007, Volume: 75, Issue:5 Topics: Butyric Acid; Lactams; Lactones; Magnetic Resonance Spectroscopy; Micromonosporaceae; Pyrroles	2007
NPI-0052, a novel proteasome inhibitor, induces caspase-8 and ROS-dependent apoptosis alone and in combination with HDAC inhibitors in leukemia cells. Blood, 2007, Jul-01, Volume: 110, Issue:1 Topics: Animals; Apoptosis; Caspase 8; Cell Line, Tumor; Histone Deacetylase Inhibitors; Humans; Lactones; Leukemia; Mice; Oxidative Stress; Protease Inhibitors; Proteasome Inhibitors; Pyrroles; Reactive Oxygen Species; Tumor Burden; Tumor Cells, Cultured	2007
Effects of halogens on the production of salinosporamides by the obligate marine actinomycete Salinispora tropica. The Journal of antibiotics, 2007, Volume: 60, Issue:1 Topics: Actinomycetales; Bromides; Chromatography, High Pressure Liquid; Culture Media; Lactones; Molecular Structure; Pyrroles; Sodium Compounds; Sodium Fluoride; Sodium Iodide	2007
Concise total synthesis of (+/-)-salinosporamide A, (+/-)-cinnabaramide A, and derivatives via a bis-cyclization process: implications for a biosynthetic pathway? Organic letters, 2007, May-24, Volume: 9, Issue:11 Topics: Color; Lactones; Molecular Structure; Pyrroles	2007
Enantioselective total synthesis of (-)-Salinosporamide A (NPI-0052). Organic letters, 2007, Jun-07, Volume: 9, Issue:12 Topics: Crystallography, X-Ray; Lactones; Models, Molecular; Molecular Conformation; Pyrroles; Stereoisomerism	2007
A mechanistic and kinetic study of the beta-lactone hydrolysis of Salinosporamide A (NPI-0052), a novel proteasome inhibitor. Journal of pharmaceutical sciences, 2007, Volume: 96, Issue:8 Topics: beta-Cyclodextrins; Buffers; Chromatography, High Pressure Liquid; Deuterium Oxide; Drug Stability; Enzyme Inhibitors; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Lactones; Mass Spectrometry; Molecular Structure; Osmolar Concentration; Proteasome Inhibitors; Pyrroles; Solubility; Solutions; Temperature; Water	2007
Salinosporamide A (NPI-0052) potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through down-modulation of NF-kappaB regulated gene products. Blood, 2007, Oct-01, Volume: 110, Issue:7 Topics: Active Transport, Cell Nucleus; Animals; Apoptosis; Cell Differentiation; Cell Line; Down-Regulation; Enzyme Activation; Gene Expression Regulation; Genes, Reporter; Humans; I-kappa B Proteins; Lactones; Mice; Mice, Knockout; Neoplasm Invasiveness; NF-kappa B; Osteoclasts; Phosphorylation; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrroles; RANK Ligand; Time Factors; Tumor Necrosis Factors	2007
Stabilization effect of resin on the production of potent proteasome inhibitor NPI-0052 during submerged fermentation of Salinispora tropica. The Journal of antibiotics, 2007, Volume: 60, Issue:7 Topics: Acrylic Resins; Anion Exchange Resins; Apoptosis; Fermentation; Humans; Lactones; Micromonosporaceae; Polystyrenes; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrroles	2007
Combination of proteasome inhibitors bortezomib and NPI-0052 trigger in vivo synergistic cytotoxicity in multiple myeloma. Blood, 2008, Feb-01, Volume: 111, Issue:3 Topics: Animals; Boronic Acids; Bortezomib; Cell Line, Tumor; Cell Movement; Cell Survival; Endoplasmic Reticulum; Heat-Shock Proteins; Humans; Lactones; Mice; Multiple Myeloma; Neovascularization, Pathologic; NF-kappa B; Protease Inhibitors; Proteasome Endopeptidase Complex; Pyrazines; Pyrroles; Xenograft Model Antitumor Assays	2008
Discovery and characterization of a marine bacterial SAM-dependent chlorinase. Nature chemical biology, 2008, Volume: 4, Issue:1 Topics: Bacterial Proteins; Crystallography, X-Ray; Genes, Bacterial; Hydrocarbons, Chlorinated; Lactones; Micromonosporaceae; Protein Conformation; Pyrroles; S-Adenosylmethionine; Substrate Specificity	2008
Defined salt formulations for the growth of Salinispora tropica strain NPS21184 and the production of salinosporamide A (NPI-0052) and related analogs. Applied microbiology and biotechnology, 2008, Volume: 78, Issue:5 Topics: Culture Media; Geologic Sediments; Industrial Microbiology; Lactones; Mass Spectrometry; Micromonosporaceae; Pyrroles; Sodium Chloride	2008
A low-sodium-salt formulation for the fermentation of salinosporamides by Salinispora tropica strain NPS21184. Applied microbiology and biotechnology, 2008, Volume: 78, Issue:5 Topics: Culture Media; Fermentation; Industrial Microbiology; Lactams; Lactones; Micromonosporaceae; Pyrroles; Seawater; Sodium Compounds	2008
Dual targeting of the proteasome regulates survival and homing in Waldenstrom macroglobulinemia. Blood, 2008, May-01, Volume: 111, Issue:9 Topics: Boronic Acids; Bortezomib; Cell Adhesion; Cell Death; Cell Movement; Cells, Cultured; Drug Delivery Systems; Drug Synergism; Humans; Lactones; Proteasome Inhibitors; Pyrazines; Pyrroles; Waldenstrom Macroglobulinemia	2008
Mutasynthesis of fluorosalinosporamide, a potent and reversible inhibitor of the proteasome. Angewandte Chemie (International ed. in English), 2008, Volume: 47, Issue:21 Topics: Binding Sites; Biological Factors; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Genetic Engineering; Humans; Hydrocarbons, Fluorinated; Lactams; Lactones; Proteasome Inhibitors; Pyrroles; Saccharomyces cerevisiae; Structure-Activity Relationship	2008
Inhibition of Yin Yang 1-dependent repressor activity of DR5 transcription and expression by the novel proteasome inhibitor NPI-0052 contributes to its TRAIL-enhanced apoptosis in cancer cells. Journal of immunology (Baltimore, Md. : 1950), 2008, May-01, Volume: 180, Issue:9 Topics: Apoptosis; Boronic Acids; Bortezomib; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Hematopoietic Stem Cells; Humans; Lactones; Neoplasms; NF-kappa B; Protease Inhibitors; Pyrazines; Pyrroles; Receptors, TNF-Related Apoptosis-Inducing Ligand; RNA, Messenger; RNA, Small Interfering; TNF-Related Apoptosis-Inducing Ligand; Transcription, Genetic; Up-Regulation; YY1 Transcription Factor	2008
Engineered biosynthesis of antiprotealide and other unnatural salinosporamide proteasome inhibitors. Journal of the American Chemical Society, 2008, Jun-25, Volume: 130, Issue:25 Topics: Lactams; Lactones; Micromonosporaceae; Molecular Structure; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein Engineering; Pyrroles	2008
Marine actinomycetes: a new source of compounds against the human malaria parasite. PloS one, 2008, Jun-04, Volume: 3, Issue:6 Topics: Actinobacteria; Animals; Antimalarials; Lactones; Marine Biology; Plasmodium falciparum; Pyrroles	2008
Entry to heterocycles based on indium-catalyzed conia-ene reactions: asymmetric synthesis of (-)-salinosporamide A. Angewandte Chemie (International ed. in English), 2008, Volume: 47, Issue:33 Topics: Catalysis; Cysteine Proteinase Inhibitors; Indium; Lactones; Proteasome Inhibitors; Pyrroles	2008
A concise and straightforward total synthesis of (+/-)-salinosporamide A, based on a biosynthesis model. Organic & biomolecular chemistry, 2008, Aug-07, Volume: 6, Issue:15 Topics: Aldehydes; Lactones; Malonates; Models, Biological; Molecular Structure; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrroles; Pyrrolidinones; Stereoisomerism	2008
Growth of Salinispora tropica strains CNB440, CNB476, and NPS21184 in nonsaline, low-sodium media. Applied microbiology and biotechnology, 2008, Volume: 80, Issue:5 Topics: Culture Media; Lactones; Micromonosporaceae; Pyrroles; Seawater; Sodium Chloride	2008
Proteasome inhibition activates epidermal growth factor receptor (EGFR) and EGFR-independent mitogenic kinase signaling pathways in pancreatic cancer cells. Clinical cancer research : an official journal of the American Association for Cancer Research, 2008, Aug-15, Volume: 14, Issue:16 Topics: Adenocarcinoma; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Bevacizumab; Blotting, Western; Boronic Acids; Bortezomib; Cell Line, Tumor; Cetuximab; Deoxycytidine; ErbB Receptors; Erlotinib Hydrochloride; Female; Gemcitabine; Humans; Lactones; Mice; Mice, Nude; Pancreatic Neoplasms; Phosphatidylinositol 3-Kinases; Protease Inhibitors; Proteasome Inhibitors; Pyrazines; Pyrroles; Quinazolines; Signal Transduction; Xenograft Model Antitumor Assays	2008
Total synthesis of salinosporamide A. Organic letters, 2008, Oct-02, Volume: 10, Issue:19 Topics: Cyclohexenes; Lactones; Pyrroles; Stereoisomerism; Substrate Specificity	2008
Discovery and development of the anticancer agent salinosporamide A (NPI-0052). Bioorganic & medicinal chemistry, 2009, Mar-15, Volume: 17, Issue:6 Topics: Antineoplastic Agents; Drug Discovery; Drugs, Investigational; Lactones; Molecular Structure; Pyrroles	2009
Antiprotealide is a natural product. Journal of natural products, 2009, Feb-27, Volume: 72, Issue:2 Topics: Actinobacteria; Animals; Biological Products; Drug Screening Assays, Antitumor; Humans; Inhibitory Concentration 50; Lactams; Lactones; Marine Biology; Molecular Structure; Proteasome Endopeptidase Complex; Pyrroles; Rabbits	2009
Caspase-8 dependent histone acetylation by a novel proteasome inhibitor, NPI-0052: a mechanism for synergy in leukemia cells. Blood, 2009, Apr-30, Volume: 113, Issue:18 Topics: Acetylation; Antioxidants; Apoptosis; Boronic Acids; Bortezomib; Caspase 8; Drug Synergism; Drug Therapy, Combination; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Immunoblotting; Immunoprecipitation; Lactones; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid, Acute; Oxidative Stress; Protease Inhibitors; Proteasome Inhibitors; Protein Processing, Post-Translational; Pyrazines; Pyrroles; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Superoxides; Tumor Cells, Cultured; Vorinostat	2009
Effect of cobalt and vitamin B12 on the production of salinosporamides by Salinispora tropica. The Journal of antibiotics, 2009, Volume: 62, Issue:4 Topics: Actinomycetales; Chromatography, High Pressure Liquid; Cobalt; Culture Media; Fermentation; Lactams; Lactones; Molecular Conformation; Pyrroles; Vitamin B 12	2009
Control of HIF-1alpha expression by eIF2 alpha phosphorylation-mediated translational repression. Cancer research, 2009, Mar-01, Volume: 69, Issue:5 Topics: Basic Helix-Loop-Helix Transcription Factors; Boronic Acids; Bortezomib; Cell Line, Tumor; Down-Regulation; Eukaryotic Initiation Factor-2; Gene Expression Regulation; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lactones; Phosphorylation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Biosynthesis; Pyrazines; Pyrroles; RNA, Messenger; Vascular Endothelial Growth Factor A	2009
Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine. Proceedings of the National Academy of Sciences of the United States of America, 2009, Jul-28, Volume: 106, Issue:30 Topics: Bacterial Proteins; Chromatography, High Pressure Liquid; Cladribine; Cloning, Molecular; Gene Order; Genome, Bacterial; Kinetics; Lactones; Malonyl Coenzyme A; Micromonosporaceae; Models, Chemical; Molecular Sequence Data; Molecular Structure; Multigene Family; Mutation; Phylogeny; Polyketide Synthases; Pyrroles; S-Adenosylmethionine; Sequence Analysis, DNA; Substrate Specificity	2009
Inhibition of epithelial to mesenchymal transition in metastatic prostate cancer cells by the novel proteasome inhibitor, NPI-0052: pivotal roles of Snail repression and RKIP induction. Oncogene, 2009, Oct-08, Volume: 28, Issue:40 Topics: Cell Differentiation; Cell Line, Tumor; Cell Movement; Epithelial Cells; Gene Expression Regulation, Neoplastic; Humans; Lactones; Male; Mesoderm; Neoplasm Invasiveness; Neoplasm Metastasis; NF-kappa B; Phosphatidylethanolamine Binding Protein; Prostatic Neoplasms; Protease Inhibitors; Proteasome Inhibitors; Pyrroles; Snail Family Transcription Factors; Transcription Factors	2009
Function-oriented biosynthesis of beta-lactone proteasome inhibitors in Salinispora tropica. Journal of medicinal chemistry, 2009, Oct-08, Volume: 52, Issue:19 Topics: Actinobacteria; Inhibitory Concentration 50; Lactones; Protease Inhibitors; Proteasome Inhibitors; Protein Engineering; Pyrroles; Structure-Activity Relationship	2009
Pivotal roles of snail inhibition and RKIP induction by the proteasome inhibitor NPI-0052 in tumor cell chemoimmunosensitization. Cancer research, 2009, Nov-01, Volume: 69, Issue:21 Topics: Adenocarcinoma; Antineoplastic Agents; Apoptosis; Blotting, Western; Boronic Acids; Bortezomib; Cisplatin; Humans; Lactones; Leupeptins; Male; Melanoma; Membrane Potential, Mitochondrial; NF-kappa B; Phosphatidylethanolamine Binding Protein; Prostatic Neoplasms; Proteasome Inhibitors; Proto-Oncogene Proteins c-raf; Pyrazines; Pyrroles; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Snail Family Transcription Factors; TNF-Related Apoptosis-Inducing Ligand; Transcription Factors; Transfection; Tumor Cells, Cultured	2009
Proteasome inhibitors activate autophagy as a cytoprotective response in human prostate cancer cells. Oncogene, 2010, Jan-21, Volume: 29, Issue:3 Topics: Animals; Autophagy; Autophagy-Related Protein 5; Autophagy-Related Protein 7; Boronic Acids; Bortezomib; Cell Line; Cell Line, Tumor; Cell Survival; Humans; Immunoblotting; Lactones; Lysosomes; Male; Microscopy, Electron, Transmission; Microtubule-Associated Proteins; Phagosomes; Prostatic Neoplasms; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Pyrroles; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Ubiquitin-Activating Enzymes	2010
Combination of novel proteasome inhibitor NPI-0052 and lenalidomide trigger in vitro and in vivo synergistic cytotoxicity in multiple myeloma. Blood, 2010, Jan-28, Volume: 115, Issue:4 Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Division; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Drug Resistance, Neoplasm; Drug Synergism; Humans; In Vitro Techniques; Lactones; Lenalidomide; Mice; Mice, SCID; Multiple Myeloma; Proteasome Inhibitors; Pyrroles; Thalidomide; Xenograft Model Antitumor Assays	2010
Pharmacodynamic and efficacy studies of the novel proteasome inhibitor NPI-0052 (marizomib) in a human plasmacytoma xenograft murine model. British journal of haematology, 2010, Volume: 149, Issue:4 Topics: Animals; Antineoplastic Agents; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Humans; Kidney; Lactones; Male; Mice; Plasmacytoma; Proteasome Inhibitors; Pyrroles; Rats; Rats, Sprague-Dawley; Tumor Cells, Cultured; Xenograft Model Antitumor Assays	2010
Concise formal synthesis of (-)-salinosporamide A (marizomib) using a regio- and stereoselective epoxidation and reductive oxirane ring-opening strategy. The Journal of organic chemistry, 2010, Jun-04, Volume: 75, Issue:11 Topics: Epoxy Compounds; Ethylene Oxide; Lactones; Proteasome Inhibitors; Pyrroles; Pyrrolidinones; Stereoisomerism	2010
A(1,3)-strain enabled retention of chirality during bis-cyclization of beta-ketoamides: total synthesis of (-)-salinosporamide A and (-)-homosalinosporamide A. Chemical communications (Cambridge, England), 2010, Jul-14, Volume: 46, Issue:26 Topics: Amides; Antineoplastic Agents; Crystallography, X-Ray; Cyclization; Lactones; Molecular Conformation; Pyrroles; Stereoisomerism	2010
Bioinspired total synthesis and human proteasome inhibitory activity of (-)-salinosporamide A, (-)-homosalinosporamide A, and derivatives obtained via organonucleophile promoted bis-cyclizations. The Journal of organic chemistry, 2011, Jan-07, Volume: 76, Issue:1 Topics: Antineoplastic Agents; Catalysis; Crystallography, X-Ray; Cyclization; Humans; Lactones; Magnetic Resonance Spectroscopy; Molecular Conformation; Molecular Structure; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrroles; Stereoisomerism	2011
Total synthesis of (-)-salinosporamide A. Chemistry, an Asian journal, 2011, Jan-03, Volume: 6, Issue:1 Topics: Lactones; Molecular Structure; Pyrroles	2011
Proteasome regulator marizomib (NPI-0052) exhibits prolonged inhibition, attenuated efflux, and greater cytotoxicity than its reversible analogs. The Journal of pharmacology and experimental therapeutics, 2011, Volume: 337, Issue:2 Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Transporters; Cell Adhesion; Cell Line, Tumor; Cell Survival; Humans; Lactams; Lactones; Proteasome Endopeptidase Complex; Pyrroles	2011
Mining the cinnabaramide biosynthetic pathway to generate novel proteasome inhibitors. Chembiochem : a European journal of chemical biology, 2011, Apr-11, Volume: 12, Issue:6 Topics: Biosynthetic Pathways; Cell Line, Tumor; Humans; Lactones; Multigene Family; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrroles; Streptomyces	2011
Total synthesis of (-)-salinosporamide A. Organic letters, 2011, Jun-17, Volume: 13, Issue:12 Topics: Antineoplastic Agents; Lactones; Molecular Structure; Proteasome Inhibitors; Pyrroles; Stereoisomerism	2011
Stereoselective synthesis of deuterated β-cyclohexenylserine, a biosynthetic intermediate of the salinosporamides. Organic letters, 2011, Jun-17, Volume: 13, Issue:12 Topics: Cyclohexenes; Deuterium; Lactones; Molecular Structure; Pyrroles; Serine; Stereoisomerism	2011
Specific and prolonged proteasome inhibition dictates apoptosis induction by marizomib and its analogs. Chemico-biological interactions, 2011, Oct-15, Volume: 194, Issue:1 Topics: Apoptosis; Caspase 8; Humans; Lactones; Leukemia; Oxidative Stress; Protease Inhibitors; Pyrroles; Reactive Oxygen Species; Tumor Cells, Cultured	2011
Bacterial self-resistance to the natural proteasome inhibitor salinosporamide A. ACS chemical biology, 2011, Nov-18, Volume: 6, Issue:11 Topics: Actinobacteria; Biological Products; Boronic Acids; Bortezomib; Drug Resistance, Bacterial; Humans; Lactones; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Subunits; Pyrazines; Pyrroles; Substrate Specificity	2011
Trypanocidal activity of β-lactone-γ-lactam proteasome inhibitors. Planta medica, 2012, Volume: 78, Issue:2 Topics: Biological Products; Enzyme Inhibitors; Lactams; Lactones; Proteasome Inhibitors; Pyrroles; Trypanocidal Agents; Trypanosoma brucei brucei	2012
Selective overproduction of the proteasome inhibitor salinosporamide A via precursor pathway regulation. Chemistry & biology, 2011, Dec-23, Volume: 18, Issue:12 Topics: Amino Acid Sequence; Bacterial Proteins; Enzyme Inhibitors; Lactones; Micromonosporaceae; Molecular Sequence Data; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Binding; Pyrroles; Recombinant Proteins	2011
Analysing properties of proteasome inhibitors using kinetic and X-ray crystallographic studies. Methods in molecular biology (Clifton, N.J.), 2012, Volume: 832 Topics: Antineoplastic Agents; Boronic Acids; Bortezomib; Crystallography, X-Ray; Drug Design; Enzyme Inhibitors; Lactones; Multiple Myeloma; Oligopeptides; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Pyrroles; Saccharomyces cerevisiae; Threonine	2012
[Molecular targeting agents for multiple myeloma]. Nihon rinsho. Japanese journal of clinical medicine, 2012, Volume: 70 Suppl 8 Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Boron Compounds; Boronic Acids; Bortezomib; Glycine; Histone Deacetylases; Humans; Immunologic Factors; Lactones; Lenalidomide; Molecular Targeted Therapy; Multiple Myeloma; Oligopeptides; Proteasome Inhibitors; Pyrazines; Pyrroles; Thalidomide	2012
(S)-4-Trimethylsilyl-3-butyn-2-ol as an auxiliary for stereocontrolled synthesis of salinosporamide analogs with modifications at positions C2 and C5. Bioorganic & medicinal chemistry letters, 2013, Dec-15, Volume: 23, Issue:24 Topics: Aldehydes; Alkylation; Butanols; Crystallography, X-Ray; Esters; Humans; Lactones; Molecular Conformation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrroles; Stereoisomerism; Trimethylsilyl Compounds	2013
Antileukemic activity and mechanism of drug resistance to the marine Salinispora tropica proteasome inhibitor salinosporamide A (Marizomib). Molecular pharmacology, 2014, Volume: 86, Issue:1 Topics: Actinobacteria; Boronic Acids; Bortezomib; Catalysis; Cell Line, Tumor; Drug Resistance, Neoplasm; Humans; Lactones; Leukemia; Mutation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Pyrroles; Up-Regulation	2014
Diastereoselective synthesis of fused lactone-pyrrolidinones; application to a formal synthesis of (-)-salinosporamide A. Organic letters, 2014, Aug-15, Volume: 16, Issue:16 Topics: Cyclization; Lactones; Molecular Structure; Oxidation-Reduction; Pyrroles; Pyrrolidinones; Stereoisomerism	2014
Efficacy of panobinostat and marizomib in acute myeloid leukemia and bortezomib-resistant models. Leukemia research, 2015, Volume: 39, Issue:3 Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Boronic Acids; Bortezomib; Caspases; Cell Proliferation; Drug Combinations; Drug Resistance, Neoplasm; Flow Cytometry; Humans; Hydroxamic Acids; Indoles; Lactones; Leukemia, Myeloid, Acute; Panobinostat; Proteasome Inhibitors; Pyrazines; Pyrroles; Tumor Cells, Cultured	2015
Synergistic anti-myeloma activity of the proteasome inhibitor marizomib and the IMiD immunomodulatory drug pomalidomide. British journal of haematology, 2015, Volume: 171, Issue:5 Topics: Adaptor Proteins, Signal Transducing; Angiogenesis Inhibitors; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Caspases; Cell Line, Tumor; Down-Regulation; Drug Resistance, Neoplasm; Drug Synergism; Humans; Lactones; Mice, SCID; Multiple Myeloma; Peptide Hydrolases; Poly(ADP-ribose) Polymerases; Proteasome Inhibitors; Pyrroles; RNA, Small Interfering; Thalidomide; Transplantation, Heterologous; Ubiquitin-Protein Ligases	2015
Marizomib activity as a single agent in malignant gliomas: ability to cross the blood-brain barrier. Neuro-oncology, 2016, Volume: 18, Issue:6 Topics: Animals; Apoptosis; Blood-Brain Barrier; Cell Line, Tumor; Disease Models, Animal; Glioma; Lactones; Mice, Inbred BALB C; Mice, Nude; Proteasome Inhibitors; Pyrroles	2016
Induction of cell death by the novel proteasome inhibitor marizomib in glioblastoma in vitro and in vivo. Scientific reports, 2016, Jan-25, Volume: 6 Topics: Animals; Apoptosis; Biomarkers, Tumor; Bortezomib; Caspases; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Lactones; Mice; Proliferating Cell Nuclear Antigen; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrroles	2016
Grisemycin, a Bridged Angucyclinone with a Methylsulfinyl Moiety from a Marine-Derived Streptomyces sp. Organic letters, 2016, Mar-18, Volume: 18, Issue:6 Topics: Anthraquinones; Crystallography, X-Ray; Hep G2 Cells; HL-60 Cells; Humans; Lactones; Marine Biology; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Pyrroles; Streptomyces; Streptomyces griseus	2016
Multiple myeloma--translation of trial results into reality. Lancet (London, England), 2016, Jul-09, Volume: 388, Issue:10040 Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Boron Compounds; Bortezomib; Bridged Bicyclo Compounds, Heterocyclic; Clinical Trials as Topic; Cyclic N-Oxides; Drug Approval; Drug Discovery; Glycine; Humans; Indolizines; Lactones; Lenalidomide; Multiple Myeloma; Oligopeptides; Practice Guidelines as Topic; Pyridinium Compounds; Pyrroles; Thalidomide	2016
Coupled Biosynthesis of Volatiles and Salinosporamide A in Salinispora tropica. Chembiochem : a European journal of chemical biology, 2016, 10-17, Volume: 17, Issue:20 Topics: Actinobacteria; Lactones; Molecular Structure; Pyrroles; Volatile Organic Compounds	2016
Ligand Based-Pharmacophore Modeling and Extended Bi oactivity Prediction for Salinosporamide A, B and C from Marine Actino mycetes Salinispora tropica. Combinatorial chemistry & high throughput screening, 2017, Volume: 20, Issue:1 Topics: Actinobacteria; Aminopeptidases; Drug Discovery; Humans; Lactams; Lactones; Ligands; Metalloendopeptidases; Molecular Docking Simulation; Protein Binding; Pyrroles; Receptors, Glucocorticoid	2017
Marizomib for central nervous system-multiple myeloma. British journal of haematology, 2017, Volume: 177, Issue:2 Topics: Adult; Central Nervous System Neoplasms; Humans; Lactones; Male; Middle Aged; Multiple Myeloma; Pyrroles	2017
The activity and safety of novel proteasome inhibitors strategies (single, doublet and triplet) for relapsed/refractory multiple myeloma. Acta oncologica (Stockholm, Sweden), 2018, Volume: 57, Issue:2 Topics: Antineoplastic Combined Chemotherapy Protocols; Boron Compounds; Glycine; Humans; Lactones; Multiple Myeloma; Neoplasm Recurrence, Local; Oligopeptides; Proteasome Inhibitors; Pyrroles; Retrospective Studies	2018
Bortezomib Alone and in Combination With Salinosporamid A Induces Apoptosis and Promotes Pheochromocytoma Cell Death In Vitro and in Female Nude Mice. Endocrinology, 2017, 10-01, Volume: 158, Issue:10 Topics: Adrenal Gland Neoplasms; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Bortezomib; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Female; Lactones; Mice; Mice, Nude; Neoplasm Invasiveness; Neovascularization, Pathologic; Pheochromocytoma; Proteasome Inhibitors; Pyrroles	2017
A Total Synthesis of Salinosporamide A. Chemistry (Weinheim an der Bergstrasse, Germany), 2018, May-07, Volume: 24, Issue:26 Topics: Biological Products; Cyclization; Free Radicals; Lactones; Oxidation-Reduction; Proteasome Inhibitors; Pyrroles	2018
(-)-Homosalinosporamide A and Its Mode of Proteasome Inhibition: An X-ray Crystallographic Study. Marine drugs, 2018, Jul-19, Volume: 16, Issue:7 Topics: Catalytic Domain; Crystallography, X-Ray; Lactones; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrroles; X-Rays; Yeasts	2018
Total Synthesis of (-)-Salinosporamide A via a Late Stage C-H Insertion. Angewandte Chemie (International ed. in English), 2019, 07-22, Volume: 58, Issue:30 Topics: Lactones; Molecular Structure; Proteasome Inhibitors; Pyrroles	2019
NPI-0052 and γ-radiation induce a synergistic apoptotic effect in medulloblastoma. Cell death & disease, 2019, 10-16, Volume: 10, Issue:11 Topics: Apoptosis; Cell Line, Tumor; Cerebellar Neoplasms; Chemoradiotherapy; Gamma Rays; Humans; Lactones; Medulloblastoma; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrroles	2019
Therapeutic strategies for diffuse midline glioma from high-throughput combination drug screening. Science translational medicine, 2019, 11-20, Volume: 11, Issue:519 Topics: Animals; Brain Neoplasms; Brain Stem Neoplasms; Cell Death; Cell Line, Tumor; Drug Evaluation, Preclinical; Drug Synergism; Female; Glioma; High-Throughput Screening Assays; Humans; Lactones; Male; Metabolomics; Mice; Panobinostat; Pyrroles; Reproducibility of Results; Sequence Analysis, RNA; Transcription, Genetic; Xenograft Model Antitumor Assays	2019
Proteasome inhibition disrupts the metabolism of fumarate hydratase- deficient tumors by downregulating p62 and c-Myc. Scientific reports, 2019, 12-05, Volume: 9, Issue:1 Topics: Animals; Carcinoma, Renal Cell; Cell Line, Tumor; Female; Fumarate Hydratase; Gene Expression Regulation, Neoplastic; Germ-Line Mutation; Glutaminase; Glycolysis; Humans; Kidney Neoplasms; Lactate Dehydrogenase 5; Lactones; Leiomyomatosis; Mice; Mice, Nude; Neoplastic Syndromes, Hereditary; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Proto-Oncogene Proteins c-myc; Pyrroles; Sequestosome-1 Protein; Signal Transduction; Skin Neoplasms; Uterine Neoplasms; Xenograft Model Antitumor Assays	2019
Marizomib suppresses triple-negative breast cancer via proteasome and oxidative phosphorylation inhibition. Theranostics, 2020, Volume: 10, Issue:12 Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Epithelial-Mesenchymal Transition; Female; Humans; Lactones; Mice; Oxidative Phosphorylation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrroles; Triple Negative Breast Neoplasms; Xenograft Model Antitumor Assays	2020
Salinosporamide A, a Marine-Derived Proteasome Inhibitor, Inhibits T Cell Activation through Regulating Proliferation and the Cell Cycle. Molecules (Basel, Switzerland), 2020, Oct-29, Volume: 25, Issue:21 Topics: Animals; Aquatic Organisms; CD4-Positive T-Lymphocytes; Cell Proliferation; Humans; Jurkat Cells; Lactones; Lymphocyte Activation; MAP Kinase Signaling System; Mice; Micromonosporaceae; Proteasome Inhibitors; Pyrroles	2020
Marizomib sensitizes primary glioma cells to apoptosis induced by a latest-generation TRAIL receptor agonist. Cell death & disease, 2021, 06-24, Volume: 12, Issue:7 Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Brain Neoplasms; CASP8 and FADD-Like Apoptosis Regulating Protein; Caspase 8; Cell Line, Tumor; Drug Resistance, Neoplasm; Glioma; Humans; Lactones; Myeloid Cell Leukemia Sequence 1 Protein; Proteasome Inhibitors; Pyrimidines; Pyrroles; Receptors, TNF-Related Apoptosis-Inducing Ligand; Signal Transduction; Spheroids, Cellular; Thiophenes; Time Factors	2021