pyrroles has been researched along with marinopyrrole a in 22 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (9.09) | 29.6817 |
| 2010's | 17 (77.27) | 24.3611 |
| 2020's | 3 (13.64) | 2.80 |
| Authors | Studies |
|---|---|
| Fenical, W; Hughes, CC; Jensen, PR; Prieto-Davo, A | 1 |
| Dorrestein, PC; Fenical, W; Hughes, CC; La Clair, JJ; Liu, WT; Yang, YL | 1 |
| Fenical, W; Hughes, CC; Jensen, PR; Kauffman, CA | 1 |
| Chen, Y; Cheng, C; Li, R; Pan, L; Qin, Y; Song, H | 1 |
| Kanakis, AA; Sarli, V | 1 |
| Fenical, W; Haste, NM; Hensler, ME; Hughes, CC; Jensen, PR; Nizet, V; Tran, DN | 1 |
| Amin, S; Awwad, A; Cheng, C; Daughdrill, G; Dewey, A; Doi, K; Krishnegowda, G; Li, R; Liu, X; Liu, Y; Loughran, TP; Manieri, W; Qin, Y; Schonbrunn, E; Sebti, S; Sung, SS; Wang, HG; Wu, H | 1 |
| Haste, NM; Hensler, M; Li, R; Liu, Y; Nizet, V; Thienphrapa, W | 1 |
| Cheng, C; Li, J; Li, R; Liu, Y; Pan, L; Qin, Y; Song, H | 1 |
| Amin, S; Doi, K; Gowda, K; Pandey, MK; Sharma, AK; Wang, HG | 1 |
| Haste, NM; Hensler, M; Li, J; Li, R; Liu, Y; Nizet, V; Thienphrapa, W | 1 |
| Amin, S; Barth, BM; Claxton, D; Doi, K; Gowda, K; Liu, Q; Loughran, TP; Wang, HG | 1 |
| Balasis, ME; Cheng, C; Daniel, KG; Garner, TP; Gavathiotis, E; Li, J; Li, R; Liu, Y; Qin, Y; Sebti, SM | 1 |
| Amin, S; Claxton, D; Doi, K; Dower, C; Gowda, K; Lin, JM; Liu, Q; Loughran, TP; Sung, SS; Wang, HG | 1 |
| Amin, S; Cohen, GM; Gowda, K; Milani, M; Poornima, P; Varadarajan, S; Wang, HG | 1 |
| Amiot, M; Audiger, L; Descamps, G; Dousset, C; Dubreuil, D; Gomez-Bougie, P; Lebreton, J; Pellat-Deceunynck, C; Schnitzler, A; Tessier, A | 1 |
| Choi, YH; Jeon, MY; Kim, DE; Kim, S; Kim, SH; Kwon, TK; Lee, TJ; Min, KJ; Park, JW; Seo, SU; Woo, SM | 1 |
| Belani, CP; Liu, X; Rice, SJ; Wang, HG | 1 |
| Anantram, A; Degani, M | 1 |
| Abe, A; Hayakawa, F; Ichihara, M; Inoue, C; Kawamoto, Y; Murate, T; Nishizawa, Y; Nozawa, Y; Sobue, S; Suzuki, M | 1 |
| Bobinger, V; Cingolani, G; Friedrich, L; Hofstetter, RK; Iaselli, M; Ko, YH; Koeberle, A; Merk, D; Miciaccia, M; Neukirch, K; Perrone, MG; Schneider, G; Scilimati, A; Werz, O | 1 |
| Li, S; Li, W; Li, Y; Qin, Y; Song, H; Wu, P; Xiao, Y; Yan, Y; Yang, J; Zhong, W; Zou, L | 1 |
1 review(s) available for pyrroles and marinopyrrole a
| Article | Year |
|---|---|
Targeting cancer's Achilles' heel: role of BCL-2 inhibitors in cellular senescence and apoptosis.
Topics: Aniline Compounds; Antineoplastic Agents; Apoptosis; Arylsulfonates; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Carboxylic Acids; Cell Line, Tumor; Cellular Senescence; Drug Screening Assays, Antitumor; Gene Expression Regulation; Humans; Hydrophobic and Hydrophilic Interactions; Hydroxyquinolines; Indoles; Molecular Structure; Molecular Targeted Therapy; Myeloid Cell Leukemia Sequence 1 Protein; Protein Binding; Protein Conformation; Proto-Oncogene Proteins c-bcl-2; Pyrimidines; Pyrogallol; Pyrroles; Salicylates; Structure-Activity Relationship; Sulfonamides | 2019 |
21 other study(ies) available for pyrroles and marinopyrrole a
| Article | Year |
|---|---|
The marinopyrroles, antibiotics of an unprecedented structure class from a marine Streptomyces sp.
Topics: Anti-Bacterial Agents; Drug Resistance, Bacterial; Marine Biology; Methicillin Resistance; Microbial Sensitivity Tests; Molecular Structure; Pyrroles; Staphylococcus aureus; Stereoisomerism; Streptomyces | 2008 |
Marinopyrrole A target elucidation by acyl dye transfer.
Topics: Actins; Amino Acid Sequence; Biological Products; Biological Transport; Fluorescent Dyes; HCT116 Cells; Humans; Intracellular Space; Models, Molecular; Molecular Sequence Data; Protein Conformation; Pyrroles | 2009 |
Structures, reactivities, and antibiotic properties of the marinopyrroles A-F.
Topics: Anti-Bacterial Agents; Crystallography, X-Ray; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Pyrroles; Staphylococcus aureus; Stereoisomerism | 2010 |
Total synthesis of (+/-)-marinopyrrole A and its library as potential antibiotic and anticancer agents.
Topics: Combinatorial Chemistry Techniques; Molecular Structure; Pyrroles; Small Molecule Libraries; Stereoisomerism | 2010 |
Total synthesis of (±)-marinopyrrole A via copper-mediated N-arylation.
Topics: Copper; Molecular Structure; Pyrroles | 2010 |
Pharmacological properties of the marine natural product marinopyrrole A against methicillin-resistant Staphylococcus aureus.
Topics: HeLa Cells; Humans; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Molecular Structure; Pyrroles; Serum | 2011 |
Discovery of marinopyrrole A (maritoclax) as a selective Mcl-1 antagonist that overcomes ABT-737 resistance by binding to and targeting Mcl-1 for proteasomal degradation.
Topics: Animals; bcl-X Protein; Biphenyl Compounds; Drug Resistance, Neoplasm; HL-60 Cells; Humans; Jurkat Cells; K562 Cells; Leukemia; Mice; Myeloid Cell Leukemia Sequence 1 Protein; Nitrophenols; Piperazines; Proteasome Endopeptidase Complex; Proteolysis; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Sulfonamides | 2012 |
Marinopyrrole derivatives as potential antibiotic agents against methicillin-resistant Staphylococcus aureus (I).
Topics: Anti-Bacterial Agents; Humans; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Pyrroles; Structure-Activity Relationship | 2012 |
Marinopyrrole derivatives as potential antibiotic agents against methicillin-resistant Staphylococcus aureus (II).
Topics: Anti-Bacterial Agents; Drug Design; Drug Resistance, Bacterial; Gram-Positive Bacteria; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Pyrroles; Staphylococcus aureus; Staphylococcus epidermidis; Structure-Activity Relationship; Vancomycin | 2013 |
Proteasomal degradation of Mcl-1 by maritoclax induces apoptosis and enhances the efficacy of ABT-737 in melanoma cells.
Topics: Adaptor Proteins, Signal Transducing; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Biphenyl Compounds; Caspases; Cell Line, Tumor; Cell Survival; Drug Synergism; Drug Therapy, Combination; Epithelial Cells; Gene Expression Regulation, Neoplastic; Growth Inhibitors; Humans; Inhibitory Concentration 50; Membrane Proteins; Mitochondria; Myeloid Cell Leukemia Sequence 1 Protein; Nitrophenols; Piperazines; Proteasome Endopeptidase Complex; Proteolysis; Proto-Oncogene Proteins; Pyrroles; Signal Transduction; Skin; Sulfonamides | 2013 |
Marinopyrrole derivatives as potential antibiotic agents against methicillin-resistant Staphylococcus aureus (III).
Topics: Anti-Bacterial Agents; Humans; In Vitro Techniques; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Molecular Conformation; Pyrroles; Structure-Activity Relationship | 2014 |
Maritoclax induces apoptosis in acute myeloid leukemia cells with elevated Mcl-1 expression.
Topics: Animals; Antineoplastic Agents; Apoptosis; Biphenyl Compounds; Bone Marrow Cells; Cell Line, Tumor; Coculture Techniques; Daunorubicin; Drug Resistance, Neoplasm; Drug Synergism; Hematopoietic Stem Cells; Heterografts; Humans; Leukemia, Myeloid, Acute; Male; Mice, Inbred C57BL; Mice, Nude; Myeloid Cell Leukemia Sequence 1 Protein; Nitrophenols; Piperazines; Pyrroles; RNA Interference; Stromal Cells; Sulfonamides | 2014 |
Design, synthesis and evaluation of marinopyrrole derivatives as selective inhibitors of Mcl-1 binding to pro-apoptotic Bim and dual Mcl-1/Bcl-xL inhibitors.
Topics: Apoptosis Regulatory Proteins; bcl-X Protein; Binding Sites; Dose-Response Relationship, Drug; Drug Design; Humans; Molecular Structure; Myeloid Cell Leukemia Sequence 1 Protein; Pyrroles; Structure-Activity Relationship | 2015 |
Pyoluteorin derivatives induce Mcl-1 degradation and apoptosis in hematological cancer cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Drug Resistance, Neoplasm; Drug Synergism; Female; Hematologic Neoplasms; Humans; Models, Molecular; Molecular Conformation; Myeloid Cell Leukemia Sequence 1 Protein; Phenols; Protein Binding; Protein Interaction Domains and Motifs; Proteolysis; Pyrroles; Stromal Cells; Time Factors; Tumor Burden; Xenograft Model Antitumor Assays | 2014 |
Maritoclax and dinaciclib inhibit MCL-1 activity and induce apoptosis in both a MCL-1-dependent and -independent manner.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Tumor; Cyclic N-Oxides; Flow Cytometry; Gene Knockdown Techniques; Humans; Indolizines; Myeloid Cell Leukemia Sequence 1 Protein; Pyridinium Compounds; Pyrroles | 2015 |
The selectivity of Marinopyrrole A to induce apoptosis in MCL1
Topics: Apoptosis; Cell Line, Tumor; Cell Survival; Gene Expression; Humans; Multiple Myeloma; Myeloid Cell Leukemia Sequence 1 Protein; Protein Biosynthesis; Proto-Oncogene Proteins c-bcl-2; Pyrroles | 2018 |
Maritoclax Enhances TRAIL-Induced Apoptosis via CHOP-Mediated Upregulation of DR5 and miR-708-Mediated Downregulation of cFLIP.
Topics: A549 Cells; Apoptosis; CASP8 and FADD-Like Apoptosis Regulating Protein; Cell Line, Tumor; Cell Survival; Down-Regulation; Drug Synergism; Gene Expression Regulation, Neoplastic; Humans; MicroRNAs; Neoplasms; Pyrroles; Receptors, TNF-Related Apoptosis-Inducing Ligand; TNF-Related Apoptosis-Inducing Ligand; Transcription Factor CHOP; Up-Regulation | 2018 |
EGFR mutations and AKT phosphorylation are markers for sensitivity to combined MCL-1 and BCL-2/xL inhibition in non-small cell lung cancer.
Topics: Antineoplastic Agents; Apoptosis; bcl-X Protein; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm; ErbB Receptors; Flow Cytometry; Humans; Mutation; Myeloid Cell Leukemia Sequence 1 Protein; Oncogene Protein v-akt; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Pyrroles | 2019 |
Involvement of MCL1, c-myc, and cyclin D2 protein degradation in ponatinib-induced cytotoxicity against T315I(+) Ph+leukemia cells.
Topics: Antineoplastic Agents; Cell Death; Cell Line, Tumor; Cyclin D2; Drug Resistance, Neoplasm; Drug Synergism; Glycogen Synthase Kinase 3; Humans; Imatinib Mesylate; Imidazoles; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leupeptins; Macrocyclic Compounds; Myeloid Cell Leukemia Sequence 1 Protein; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Protein Phosphatase 2; Proteolysis; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-myc; Pyridazines; Pyrroles; Signal Transduction; Wortmannin | 2020 |
Learning from Nature: From a Marine Natural Product to Synthetic Cyclooxygenase-1 Inhibitors by Automated De Novo Design.
Topics: Artificial Intelligence; Biological Products; Cyclooxygenase Inhibitors; Drug Design; Drug Discovery; Pyrroles | 2021 |
Synthesis of 10,10'-bis(trifluoromethyl) marinopyrrole A derivatives and evaluation of their antiviral activities in vitro.
Topics: Antiviral Agents; Enterovirus; Enterovirus Infections; Flavivirus; Humans; Pyrroles; Zika Virus; Zika Virus Infection | 2022 |