Compounds > pyrroles
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pyrroles and ly2109761

pyrroles has been researched along with ly2109761 in 53 studies

Research

Studies (53)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's6 (11.32)29.6817
2010's40 (75.47)24.3611
2020's7 (13.21)2.80

Authors

AuthorsStudies
Anderson, BD; Britt, KS; Campbell, RM; Clawson, DK; Dierks, EA; Heap, CR; Huss, KL; King, CH; Li, HY; McCann, DJ; McMillen, WT; Mundla, SR; Sawyer, JS; Voss, MD; Wang, Y; Yan, L; Yingling, JM1
Abbruzzese, JL; Chiao, PJ; Fleming, JB; Ishiyama, S; Melisi, D; Sclabas, GM; Tortora, G; Xia, Q1
Andreeff, M; Jin, L; Konopleva, M; McQueen, T; Ohsaka, A; Tabe, Y; Watt, J; Xu, Y1
Antonaci, S; Fransvea, E; Giannelli, G; Mazzocca, A1
Datta, PK; Halder, SK; Zhang, B; Zhang, S1
Antonaci, S; Fransvea, E; Giannelli, G; Lavezzari, G; Mazzocca, A1
Antonaci, S; Dituri, F; Fransvea, E; Giannelli, G; Lupo, L; Mazzocca, A1
Cho, YJ; Datta, A; Datta, PK; Gorden, DL; Halder, SK; Kashikar, ND; Zhang, B1
Beyer, M; Classen, S; Debey-Pascher, S; Eggle, D; Kuhn, W; Lahn, M; Mallmann, MR; Muth, C; Pölcher, M; Rudlowski, C; Schultze, JL; Staratschek-Jox, A; Zander, T1
Banach-Petrosky, W; Biswas, S; Ganapathy, V; Ge, R; Grazioli, A; Kang, Y; Lonning, S; McPherson, J; Mundy, GR; Reiss, M; Xie, W; Yingling, JM1
Antonaci, S; Azzariti, A; Fransvea, E; Giannelli, G; Mazzocca, A; Santamato, A1
Akhurst, RJ; Connolly, EC; De Sapio, A; Hann, B; Luu, MT; Quigley, D; Saunier, EF; Yingling, JM1
Han, N; Hauser, K; Herion, TW; Huber, PE; Lahn, M; Peschke, P; Timke, C; Weber, KJ; Wirkner, U; Zhang, M1
Debus, J; Han, N; Huber, PE; Kleber, S; Lahn, M; Martin-Villalba, A; Peschke, P; Röhrich, M; Timke, C; Tuettenberg, J; Wirkner, U; Zhang, M1
Akhurst, RJ; Babb, JS; Barcellos-Hoff, MH; Bouquet, F; Demaria, S; DeWyngaert, JK; Formenti, SC; Hann, B; Lonning, SM; Pal, A; Pilones, KA1
Kundra, V; Li, ZG; Navone, NM; Ravoori, MK; Starbuck, MW; Vazquez, E; Wan, X; Yang, J; Yingling, JM1
Baldassarre, F; Ciccarella, G; De Santis, F; Giannelli, G; Leporatti, S; Lucarelli, G; Rinaldi, R; Scarlino, F; Torre, AD; Vergaro, V1
Bickelhaupt, S; Dadrich, M; Flechsig, P; Gröne, HJ; Hahn, EW; Hauser, K; Huber, PE; Jenne, J; Lahn, M; Peschke, P; Timke, C; Wirkner, U; Yingling, J1
De Santis, F; Dituri, F; Fabregat, I; Fernando, J; Giannelli, G; Mazzocca, A; Papappicco, P; Paradiso, A; Peidrò, FJ; Sabbà, C1
Almendro, V; Bessarabova, M; Caldas, C; Carver, K; Ekram, MB; Feng, J; Kim, JH; Liu, XS; Maruyama, R; Moen Vollan, HK; Nikolsky, Y; Peluffo, G; Polyak, K; Rueda, OM; Russnes, HG; Sun, H; Takagi, S; Vaske, C; Wu, Z; Yamamoto, S; Zhao, X; Zucca, M1
Bardot, E; Castillo-Martin, M; Castro, V; Cordon-Cardo, C; de la Iglesia-Vicente, J; Ezhkova, E; Iavarone, A; Llobet-Navas, D; Marshall, N; Olivan, M; Putcha, P; Rodriguez-Barrueco, R; Saucedo-Cuevas, L; Silva, JM1
Chen, X; Ding, H; Lan, L; Li, X; Lin, B; Luo, H; Wang, Y; Wu, J; Zhang, H1
Jiang, YS; Ma, JF; Mu, LP; Ren, XF; Wang, L1
Jeon, M; Kim, S; Lee, J; Lee, JE; Nam, SJ1
Gao, Z; Liu, W; Wang, X; Wu, X; Zhang, W; Zhou, G1
Gao, L; Gao, Y; Li, J; Shan, N; Wang, Y; Xu, F; Yi, Z; Yu, X; Zhao, C1
Angelucci, E; Annese, T; Catacchio, I; Dammacco, F; De Veirman, K; Derudas, D; Desantis, V; Di Marzo, L; Frassanito, MA; Fumarulo, R; Maffia, M; Menu, E; Nico, B; Racanelli, V; Ria, R; Ribatti, D; Ruggieri, S; Vacca, A; Vanderkerken, K; Vergara, D1
Alsina-Sanchis, E; Casanovas, O; Figueras, A; Graupera, M; Lahiguera, Á; Vidal, A; Villanueva, A; Viñals, F1
Jiang, X; Qi, B; Wang, Z; Xia, H; Zhou, T1
Brounts, S; Galante, J; Gao, S; Gorski, D; Li, J; Luo, W; Plaas, A; Sandy, J; Trella, K1
Cui, Z; Jin, X; Jin, Y; Li, X; Peng, J1
Fang, J; Hua, J; Lv, C; Peng, S; Wei, Y; Zhao, S1
Asano, Y; Fukushima, S; Hashizume, Y; Ide, M; Ihn, H; Jinnin, M; Kajihara, I; Tomizawa, Y; Wang, Z1
Li, Y; Liang, Y; Liu, H; Ma, X; Peng, P; Zhang, X1
Chen, Q; Gao, MQ; Li, X; Qi, S; Wang, X; Yang, W; Zhang, Y1
Bai, J; Fang, R; Lai, W; Li, Q; Mo, Y; Si, Y; Wu, J1
Dai, X; Gao, W; Li, H; Li, X; Liu, Q; Xi, Z; Yan, Y; Yang, Y; Zhou, X; Zhou, Y1
Adhyatmika, A; Adlia, A; de Jong, KP; Luangmonkong, T; Mutsaers, HAM; Olinga, P; Oosterhuis, D; Suriguga, S; Suthisisang, C1
Guo, Y; Han, C; Han, G; Liu, L; Tan, X; Wei, G; Xu, Q; Zhang, C; Zhang, H1
Bai, Y; Liu, M; Shen, D; Tao, S; Wang, T; Zhang, W1
Ke, BL; Liu, K; Miao, YY; Xu, X; Zhang, ZH1
Liang, DY; Liu, QH; Peng, YB; Shen, J; Wang, Q; Xu, WH1
He, MF; He, ZH; Sun, DY; Sun, HB; Wu, JQ1
Gao, L; Li, R; Li, Y; Lu, W; Peng, M; Qiu, C; Shan, Y; Wang, X; Zheng, X1
Ding, L; Huang, T; Jiang, H; Liang, Y; Liu, Y; Sattar, S; Shang, Y; Wang, M; Wei, Y; Wu, B; Yang, T; Zhang, D; Zhou, F1
Cheng, K; Fetse, JP; Jain, A; Li, Y; Lin, CY; Liu, H; Zhao, Z1
Guo, D; Guo, X; Huang, T; Liu, Z; Song, J; Wang, B; Wu, X; Yang, Z; Zhao, J1
Han, Y; Li, Y; Sun, P; Xu, N1
Jian, X; Kan, B; Kong, L; Ning, Q; Ren, Y; Zhang, Z1
Chen, X; Chen, XP; Datta, PK; Dong, SL; Dong, W; Leng, C; Luo, X; Wang, C; Yin, P; Zhang, BH; Zhang, BX1
Bin, Y; Chen, X; Chen, Y; Li, G; Yan, H; Zhou, X1
Fang, Q; Liu, P; Ma, D; Ni, M; Pan, C; Wang, J; Zhang, S1
Chang, Y; Dai, X; Ji, S; Jiang, Z; Li, B; Li, C; Li, D; Liang, R; Ruan, S; Sun, J; Wang, Z; Yang, M; Zhao, H1

Other Studies

53 other study(ies) available for pyrroles and ly2109761

ArticleYear
Optimization of a dihydropyrrolopyrazole series of transforming growth factor-beta type I receptor kinase domain inhibitors: discovery of an orally bioavailable transforming growth factor-beta receptor type I inhibitor as antitumor agent.
    Journal of medicinal chemistry, 2008, Apr-10, Volume: 51, Issue:7

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Biological Availability; Cell Proliferation; Crystallography, X-Ray; Drug Design; Humans; Mice; Mice, Nude; Models, Molecular; Molecular Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrazoles; Pyrroles; Rats; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Stereoisomerism; Structure-Activity Relationship; Xenograft Model Antitumor Assays

2008
LY2109761, a novel transforming growth factor beta receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis.
    Molecular cancer therapeutics, 2008, Volume: 7, Issue:4

    Topics: Animals; Anoikis; Antimetabolites, Antineoplastic; Apoptosis; Cell Movement; Deoxycytidine; Drug Therapy, Combination; Gemcitabine; Humans; Lung Neoplasms; Mice; Mice, Inbred C57BL; Mice, Nude; Neoplasm Invasiveness; Neovascularization, Pathologic; Pancreatic Neoplasms; Phosphorylation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrazoles; Pyrroles; Receptor, Transforming Growth Factor-beta Type I; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Ribonucleotide Reductases; Signal Transduction; Smad2 Protein; Survival Rate; Transforming Growth Factor beta; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2008
TGF-beta receptor kinase inhibitor LY2109761 reverses the anti-apoptotic effects of TGF-beta1 in myelo-monocytic leukaemic cells co-cultured with stromal cells.
    British journal of haematology, 2008, Volume: 142, Issue:2

    Topics: Apoptosis; Blotting, Western; Cell Cycle; Cell Line, Tumor; Cells, Cultured; Coculture Techniques; Enzyme Inhibitors; Humans; Leukemia; Lipopolysaccharide Receptors; Mesenchymal Stem Cells; Pyrazoles; Pyrroles; Receptors, Transforming Growth Factor beta; Stromal Cells; Transforming Growth Factor beta1; U937 Cells

2008
Targeting transforming growth factor (TGF)-betaRI inhibits activation of beta1 integrin and blocks vascular invasion in hepatocellular carcinoma.
    Hepatology (Baltimore, Md.), 2009, Volume: 49, Issue:3

    Topics: Aged; Cadherins; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cells, Cultured; Endothelium, Vascular; Enzyme Inhibitors; Extracellular Matrix Proteins; Female; Humans; Integrin alpha5beta1; Integrin beta1; Liver Neoplasms; Male; Neovascularization, Pathologic; Protein Serine-Threonine Kinases; Pyrazoles; Pyrroles; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Smad2 Protein; Smad3 Protein; Transforming Growth Factor beta1

2009
Targeting transforming growth factor-beta signaling in liver metastasis of colon cancer.
    Cancer letters, 2009, May-08, Volume: 277, Issue:1

    Topics: Animals; Cell Line, Tumor; Cell Movement; Colonic Neoplasms; Genes, ras; Humans; Liver Neoplasms; Mice; Mice, Inbred BALB C; Mutation; Neoplasm Invasiveness; Pyrazoles; Pyrroles; Signal Transduction; Smad Proteins; Transforming Growth Factor beta

2009
Inhibition of transforming growth factor beta receptor I kinase blocks hepatocellular carcinoma growth through neo-angiogenesis regulation.
    Hepatology (Baltimore, Md.), 2009, Volume: 50, Issue:4

    Topics: Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Bevacizumab; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Chick Embryo; Embryonic Development; Humans; Liver Neoplasms; Neovascularization, Pathologic; Protein Serine-Threonine Kinases; Pyrazoles; Pyrroles; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Signal Transduction; Smad Proteins; Transforming Growth Factor beta1; Vascular Endothelial Growth Factor A

2009
Down-regulation of connective tissue growth factor by inhibition of transforming growth factor beta blocks the tumor-stroma cross-talk and tumor progression in hepatocellular carcinoma.
    Hepatology (Baltimore, Md.), 2010, Volume: 51, Issue:2

    Topics: Carcinoma, Hepatocellular; Connective Tissue Growth Factor; Disease Progression; Down-Regulation; Humans; Liver Neoplasms; Pyrazoles; Pyrroles; Transforming Growth Factor beta; Tumor Cells, Cultured

2010
Antimetastatic role of Smad4 signaling in colorectal cancer.
    Gastroenterology, 2010, Volume: 138, Issue:3

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cadherins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Colorectal Neoplasms; Female; Humans; Liver Neoplasms; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Mice, Nude; Neoplasm Invasiveness; NM23 Nucleoside Diphosphate Kinases; Protein Kinase Inhibitors; Pyrazoles; Pyrroles; Receptors, Transforming Growth Factor beta; Signal Transduction; Smad4 Protein; Time Factors; Transfection; Transforming Growth Factor beta1; Urokinase-Type Plasminogen Activator

2010
Application of T cell-based transcriptomics to identify three candidate biomarkers for monitoring anti-TGFbetaR therapy.
    Pharmacogenetics and genomics, 2010, Volume: 20, Issue:3

    Topics: Biomarkers; Breast Neoplasms; Cells, Cultured; Dose-Response Relationship, Drug; Female; Gene Expression Profiling; Gene Expression Regulation; Humans; Male; Monitoring, Physiologic; Oligonucleotide Array Sequence Analysis; Ovarian Neoplasms; Prostatic Neoplasms; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrazoles; Pyrroles; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; T-Lymphocytes; Transcription, Genetic

2010
Targeting the Transforming Growth Factor-beta pathway inhibits human basal-like breast cancer metastasis.
    Molecular cancer, 2010, May-26, Volume: 9

    Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Female; Humans; Mice; Mice, Nude; Neoplasm Metastasis; Neovascularization, Pathologic; Pyrazoles; Pyrroles; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Transforming Growth Factor beta; Xenograft Model Antitumor Assays

2010
Kinase activation profile associated with TGF-β-dependent migration of HCC cells: a preclinical study.
    Cancer chemotherapy and pharmacology, 2011, Volume: 68, Issue:1

    Topics: Cadherins; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Enzyme Activation; Humans; Liver; Liver Neoplasms; Protein Kinases; Protein Serine-Threonine Kinases; Pyrazoles; Pyrroles; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Xenograft Model Antitumor Assays

2011
Outgrowth of drug-resistant carcinomas expressing markers of tumor aggression after long-term TβRI/II kinase inhibition with LY2109761.
    Cancer research, 2011, Mar-15, Volume: 71, Issue:6

    Topics: Animals; Blotting, Western; Cadherins; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Immunohistochemistry; Male; Mice; Myofibroblasts; Oligonucleotide Array Sequence Analysis; Papilloma; Phosphorylation; Protein Serine-Threonine Kinases; Pyrazoles; Pyrroles; Receptor, Transforming Growth Factor-beta Type I; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Smad2 Protein; Time Factors

2011
Trimodal glioblastoma treatment consisting of concurrent radiotherapy, temozolomide, and the novel TGF-β receptor I kinase inhibitor LY2109761.
    Neoplasia (New York, N.Y.), 2011, Volume: 13, Issue:6

    Topics: Angiopoietin-1; Angiopoietin-2; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Survival; Cells, Cultured; Combined Modality Therapy; Dacarbazine; Gene Expression Regulation, Neoplastic; Glioblastoma; Immunohistochemistry; Ki-67 Antigen; Mice; Mice, Inbred BALB C; Mice, Nude; Platelet Endothelial Cell Adhesion Molecule-1; Protein Serine-Threonine Kinases; Pyrazoles; Pyrroles; Radiotherapy; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Reverse Transcriptase Polymerase Chain Reaction; Temozolomide; Tumor Burden; Xenograft Model Antitumor Assays

2011
Blockade of TGF-β signaling by the TGFβR-I kinase inhibitor LY2109761 enhances radiation response and prolongs survival in glioblastoma.
    Cancer research, 2011, Dec-01, Volume: 71, Issue:23

    Topics: Animals; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; DNA Damage; DNA Repair; Glioblastoma; Humans; Mesenchymal Stem Cells; Mice; Mice, Inbred BALB C; Mice, SCID; Microarray Analysis; Neoplasm Invasiveness; Neoplastic Stem Cells; Neovascularization, Pathologic; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrazoles; Pyrroles; Radiation Tolerance; Radiation-Sensitizing Agents; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Signal Transduction; Smad2 Protein; Transforming Growth Factor beta; Xenograft Model Antitumor Assays

2011
TGFβ1 inhibition increases the radiosensitivity of breast cancer cells in vitro and promotes tumor control by radiation in vivo.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2011, Nov-01, Volume: 17, Issue:21

    Topics: Amino Acids; Animals; Breast Neoplasms; Cell Growth Processes; Cell Line, Tumor; Combined Modality Therapy; Female; Humans; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, SCID; Protein Serine-Threonine Kinases; Pyrazoles; Pyrroles; Radiation-Sensitizing Agents; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Transforming Growth Factor beta; Transforming Growth Factor beta1; Xanthenes; Xenograft Model Antitumor Assays

2011
Effect of transforming growth factor beta (TGF-β) receptor I kinase inhibitor on prostate cancer bone growth.
    Bone, 2012, Volume: 50, Issue:3

    Topics: Animals; Antineoplastic Agents; Bone and Bones; Bone Neoplasms; Cell Line, Tumor; Cell Proliferation; Femur; Humans; Male; Mice; Osteoblasts; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Pyrazoles; Pyrroles; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Transforming Growth Factor beta1; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2012
Polyelectrolyte capsules as carriers for growth factor inhibitor delivery to hepatocellular carcinoma.
    Macromolecular bioscience, 2012, Volume: 12, Issue:5

    Topics: Biocompatible Materials; Capsules; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Survival; Cross-Linking Reagents; Drug Carriers; Drug Compounding; Endocytosis; Glutaral; Humans; Liver Neoplasms; Microscopy, Confocal; Microscopy, Electron, Scanning; Polyamines; Polyelectrolytes; Protein Serine-Threonine Kinases; Pyrazoles; Pyrroles; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta

2012
LY2109761 attenuates radiation-induced pulmonary murine fibrosis via reversal of TGF-β and BMP-associated proinflammatory and proangiogenic signals.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2012, Jul-01, Volume: 18, Issue:13

    Topics: Angiogenic Proteins; Animals; Bone Morphogenetic Proteins; Cells, Cultured; Cone-Beam Computed Tomography; Female; Fibroblasts; Gene Expression Profiling; Humans; Inflammation Mediators; Lung; Mice; Mice, Inbred C57BL; Oligonucleotide Array Sequence Analysis; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Pyrazoles; Pyrroles; Radiation Injuries, Experimental; Radiation Pneumonitis; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Smad2 Protein; Transcription, Genetic; Transforming Growth Factor beta

2012
Differential Inhibition of the TGF-β Signaling Pathway in HCC Cells Using the Small Molecule Inhibitor LY2157299 and the D10 Monoclonal Antibody against TGF-β Receptor Type II.
    PloS one, 2013, Volume: 8, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Carcinoma, Hepatocellular; Connective Tissue Growth Factor; Female; Hep G2 Cells; Homeodomain Proteins; Humans; Liver Neoplasms; Male; Middle Aged; Protein Serine-Threonine Kinases; Pyrazoles; Pyrroles; Quinolines; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Signal Transduction; Smad2 Protein; Transcription Factors; Transforming Growth Factor beta; Vascular Endothelial Growth Factor A

2013
JARID1B is a luminal lineage-driving oncogene in breast cancer.
    Cancer cell, 2014, Jun-16, Volume: 25, Issue:6

    Topics: Breast Neoplasms; CCCTC-Binding Factor; Cell Growth Processes; Cell Line, Tumor; Cell Lineage; Female; Gene Amplification; Gene Expression Regulation, Neoplastic; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; MCF-7 Cells; Mutation; Nuclear Proteins; Oncogenes; Promoter Regions, Genetic; Pyrazoles; Pyrroles; Repressor Proteins; RNA, Small Interfering; Transfection; Transforming Growth Factor beta

2014
The microRNA 424/503 cluster reduces CDC25A expression during cell cycle arrest imposed by transforming growth factor β in mammary epithelial cells.
    Molecular and cellular biology, 2014, Dec-01, Volume: 34, Issue:23

    Topics: Animals; Apoptosis; cdc25 Phosphatases; Cell Line; Cell Proliferation; Down-Regulation; Epithelial Cells; Female; G1 Phase Cell Cycle Checkpoints; Humans; Insulin-Like Growth Factor I; Mammary Glands, Animal; Mammary Glands, Human; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; MicroRNAs; Promoter Regions, Genetic; Pyrazoles; Pyrroles; Receptors, Estrogen; Receptors, Progesterone; Transcription, Genetic; Transforming Growth Factor beta

2014
Galangin suppresses HepG2 cell proliferation by activating the TGF-β receptor/Smad pathway.
    Toxicology, 2014, Dec-04, Volume: 326

    Topics: Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Carcinoma, Hepatocellular; Cell Proliferation; Dose-Response Relationship, Drug; Flavonoids; Hep G2 Cells; Humans; Liver Neoplasms; Protein Serine-Threonine Kinases; Pyrazoles; Pyrroles; Receptor, Transforming Growth Factor-beta Type I; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; RNA Interference; Signal Transduction; Smad Proteins; Transfection; Transforming Growth Factor beta

2014
LY2109761 inhibits metastasis and enhances chemosensitivity in osteosarcoma MG-63 cells.
    European review for medical and pharmacological sciences, 2015, Volume: 19, Issue:7

    Topics: Apoptosis; Bone Neoplasms; Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm; Humans; Osteosarcoma; Pyrazoles; Pyrroles

2015
Elevated TGF-β1 and -β2 expression accelerates the epithelial to mesenchymal transition in triple-negative breast cancer cells.
    Cytokine, 2015, Volume: 75, Issue:1

    Topics: Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Movement; Enzyme-Linked Immunosorbent Assay; Epithelial-Mesenchymal Transition; Female; Fibronectins; Gene Expression Regulation, Neoplastic; Humans; Neoplasm Invasiveness; Pyrazoles; Pyrroles; RNA, Messenger; Signal Transduction; Snail Family Transcription Factors; Transcription Factors; Transforming Growth Factor beta1; Transforming Growth Factor beta2; Triple Negative Breast Neoplasms; Vimentin; Wound Healing

2015
Inhibitory effect of TGF-β peptide antagonist on the fibrotic phenotype of human hypertrophic scar fibroblasts.
    Pharmaceutical biology, 2016, Volume: 54, Issue:7

    Topics: Adult; Cell Movement; Cell Proliferation; Cells, Cultured; Cicatrix, Hypertrophic; Female; Fibrillar Collagens; Fibroblasts; Fibronectins; Fibrosis; Gene Expression Regulation; Humans; Male; Middle Aged; Peptides; Phenotype; Pyrazoles; Pyrroles; Receptors, Transforming Growth Factor beta; Signal Transduction; Skin; Time Factors; Transforming Growth Factor beta1; Young Adult

2016
LY2109761 enhances cisplatin antitumor activity in ovarian cancer cells.
    International journal of clinical and experimental pathology, 2015, Volume: 8, Issue:5

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Ovarian Epithelial; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cisplatin; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Female; Humans; Mice, Inbred ICR; Mice, SCID; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Phosphorylation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrazoles; Pyrroles; Receptor, Transforming Growth Factor-beta Type I; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Signal Transduction; Smad2 Protein; Time Factors; Transforming Growth Factor beta; Tumor Burden; Xenograft Model Antitumor Assays

2015
Halting pro-survival autophagy by TGFβ inhibition in bone marrow fibroblasts overcomes bortezomib resistance in multiple myeloma patients.
    Leukemia, 2016, Volume: 30, Issue:3

    Topics: Aged; Aged, 80 and over; Animals; Antineoplastic Agents; Autophagy; Bone Marrow Cells; Bortezomib; Drug Combinations; Drug Resistance, Neoplasm; Female; Fibroblasts; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; Microtubule-Associated Proteins; Middle Aged; Multiple Myeloma; Plasma Cells; Primary Cell Culture; Pyrazoles; Pyrroles; RNA-Binding Proteins; Signal Transduction; Survival Analysis; TOR Serine-Threonine Kinases; Transforming Growth Factor beta; Xenograft Model Antitumor Assays

2016
The TGFβ pathway stimulates ovarian cancer cell proliferation by increasing IGF1R levels.
    International journal of cancer, 2016, 10-15, Volume: 139, Issue:8

    Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Carcinoma, Ovarian Epithelial; Cell Proliferation; Female; Heterografts; Humans; Mice; Mice, Nude; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Pyrazoles; Pyrroles; Random Allocation; Receptor, IGF Type 1; Receptors, Somatomedin; Signal Transduction; Transforming Growth Factor beta

2016
HSP47 Promotes Glioblastoma Stemlike Cell Survival by Modulating Tumor Microenvironment Extracellular Matrix through TGF-β Pathway.
    ACS chemical neuroscience, 2017, 01-18, Volume: 8, Issue:1

    Topics: Analysis of Variance; Animals; Brain Neoplasms; Cell Survival; Computational Biology; Disease Models, Animal; Extracellular Matrix; Flow Cytometry; Gene Expression Regulation, Neoplastic; Glioblastoma; HSP47 Heat-Shock Proteins; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplastic Stem Cells; Platelet Endothelial Cell Adhesion Molecule-1; Pyrazoles; Pyrroles; RNA, Messenger; Transforming Growth Factor beta; Tumor Cells, Cultured; Tumor Microenvironment; Xenograft Model Antitumor Assays

2017
Degenerative Suspensory Ligament Desmitis (DSLD) in Peruvian Paso Horses Is Characterized by Altered Expression of TGFβ Signaling Components in Adipose-Derived Stromal Fibroblasts.
    PloS one, 2016, Volume: 11, Issue:11

    Topics: Adipose Tissue; Animals; Chromatin; Fibroblasts; Gene Expression Regulation; Horse Diseases; Horses; Ligaments; Male; Protein Serine-Threonine Kinases; Pyrazoles; Pyrroles; Receptor, Transforming Growth Factor-beta Type I; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Signal Transduction; Stromal Cells; Transforming Growth Factor beta; Transforming Growth Factor beta1

2016
Upregulation of long non-coding RNA PlncRNA-1 promotes proliferation and induces epithelial-mesenchymal transition in prostate cancer.
    Oncotarget, 2017, Apr-18, Volume: 8, Issue:16

    Topics: Animals; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Models, Animal; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Gene Silencing; Humans; Male; Mice; Prostatic Neoplasms; Pyrazoles; Pyrroles; RNA, Long Noncoding; Signal Transduction; Transforming Growth Factor beta1; Xenograft Model Antitumor Assays

2017
CD61 promotes the differentiation of canine ADMSCs into PGC-like cells through modulation of TGF-β signaling.
    Scientific reports, 2017, 03-03, Volume: 7

    Topics: Adipose Tissue; Animals; Cell Differentiation; Cells, Cultured; Dogs; Gene Expression; Germ Cells; Integrin beta3; Male; Mesenchymal Stem Cells; Phosphorylation; Pyrazoles; Pyrroles; Signal Transduction; Smad2 Protein; Transforming Growth Factor beta

2017
Transforming growth factor β-inhibitor Repsox downregulates collagen expression of scleroderma dermal fibroblasts and prevents bleomycin-induced mice skin fibrosis.
    Experimental dermatology, 2017, Volume: 26, Issue:11

    Topics: Actins; Amino Acids; Aminopyridines; Animals; Bleomycin; Collagen Type I; Collagen Type I, alpha 1 Chain; Connective Tissue Growth Factor; Fibroblasts; Fibrosis; Humans; Inhibitory Concentration 50; Mice; Phenols; Pyrazoles; Pyridines; Pyrroles; Scleroderma, Systemic; Signal Transduction; Skin; Transforming Growth Factor beta; Up-Regulation; Xanthenes

2017
DKK3 regulates cell proliferation, apoptosis and collagen synthesis in keloid fibroblasts via TGF-β1/Smad signaling pathway.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017, Volume: 91

    Topics: Adaptor Proteins, Signal Transducing; Adolescent; Adult; Apoptosis; Cell Proliferation; Chemokines; Collagen; Down-Regulation; Fibroblasts; Humans; Intercellular Signaling Peptides and Proteins; Keloid; Pyrazoles; Pyrroles; Signal Transduction; Smad Proteins; Transforming Growth Factor beta1; Young Adult

2017
TGF-β1 Induces EMT in Bovine Mammary Epithelial Cells Through the TGFβ1/Smad Signaling Pathway.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2017, Volume: 43, Issue:1

    Topics: Actins; Animals; Cadherins; Cattle; Cells, Cultured; Epithelial Cells; Epithelial-Mesenchymal Transition; Female; Mammary Glands, Animal; Matrix Metalloproteinase 2; Matrix Metalloproteinase 7; Mice; Phosphorylation; Pyrazoles; Pyrroles; Real-Time Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Smad Proteins; Transforming Growth Factor beta1; Up-Regulation

2017
LncRNA PlncRNA‑1 regulates proliferation and differentiation of hair follicle stem cells through TGF‑β1‑mediated Wnt/β‑catenin signal pathway.
    Molecular medicine reports, 2018, Volume: 17, Issue:1

    Topics: beta Catenin; Cell Cycle; Cell Differentiation; Cell Proliferation; Gene Expression; Hair Follicle; Pyrazoles; Pyrroles; RNA, Long Noncoding; Stem Cells; Transforming Growth Factor beta1; Wnt Signaling Pathway

2018
Transdifferentiation of type II alveolar epithelial cells induces reactivation of dormant tumor cells by enhancing TGF-β1/SNAI2 signaling.
    Oncology reports, 2018, Volume: 39, Issue:4

    Topics: Alveolar Epithelial Cells; Apoptosis; Autocrine Communication; Cell Line, Tumor; Cell Proliferation; Cell Transdifferentiation; Gene Expression Regulation, Neoplastic; Humans; Lipopolysaccharides; Lung; Monensin; Pyrazoles; Pyrroles; Signal Transduction; Snail Family Transcription Factors; Transforming Growth Factor beta1

2018
In vitro and ex vivo anti-fibrotic effects of LY2109761, a small molecule inhibitor against TGF-β.
    Toxicology and applied pharmacology, 2018, 09-15, Volume: 355

    Topics: Adenosine Triphosphate; Animals; Cell Line; Collagen Type I; Down-Regulation; Fibrosis; Gene Expression; Humans; In Vitro Techniques; Liver; Male; Phosphorylation; Pyrazoles; Pyrroles; Rats; Rats, Wistar; Smad1 Protein; Smad2 Protein; Tissue Inhibitor of Metalloproteinase-2; Transforming Growth Factor beta

2018
LY2109761 reduces TGF-β1-induced collagen production and contraction in hypertrophic scar fibroblasts.
    Archives of dermatological research, 2018, Volume: 310, Issue:8

    Topics: Actins; Cells, Cultured; Cicatrix, Hypertrophic; Collagen; Fibroblasts; Fibrosis; Humans; Protein Kinase Inhibitors; Pyrazoles; Pyrroles; Receptor, Transforming Growth Factor-beta Type I; Receptor, Transforming Growth Factor-beta Type II; Signal Transduction; Skin; Smad3 Protein; Transforming Growth Factor beta1

2018
TGF-β/Smads Signaling Affects Radiation Response and Prolongs Survival by Regulating DNA Repair Genes in Malignant Glioma.
    DNA and cell biology, 2018, Volume: 37, Issue:11

    Topics: Acid Anhydride Hydrolases; Animals; ATP-Binding Cassette Transporters; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; DNA Damage; DNA Glycosylases; DNA Modification Methylases; DNA Repair; DNA Repair Enzymes; DNA-Binding Proteins; Gamma Rays; Gene Expression Regulation, Neoplastic; Glioma; Humans; Mice; MutL Protein Homolog 1; MutS Homolog 2 Protein; Neuroglia; Pyrazoles; Pyrroles; RNA, Small Interfering; Signal Transduction; Smad Proteins; Survival Analysis; Transforming Growth Factor beta; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays

2018
LY2109761, Transforming Growth Factor β Receptor Type I and Type II Dual Inhibitor, is a Novel Approach to Suppress Endothelial Mesenchymal Transformation in Human Corneal Endothelial Cells.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2018, Volume: 50, Issue:3

    Topics: 5'-Nucleotidase; Cell Proliferation; Cells, Cultured; Cornea; Endothelial Cells; Epithelial-Mesenchymal Transition; Humans; Pyrazoles; Pyrroles; Receptors, Transforming Growth Factor beta; Signal Transduction; Sodium-Potassium-Exchanging ATPase; Up-Regulation; Vimentin

2018
Knockdown of KDM2A inhibits proliferation associated with TGF-β expression in HEK293T cell.
    Molecular and cellular biochemistry, 2019, Volume: 456, Issue:1-2

    Topics: Cell Proliferation; CRISPR-Cas Systems; F-Box Proteins; Gene Knockdown Techniques; HEK293 Cells; Humans; Jumonji Domain-Containing Histone Demethylases; Pyrazoles; Pyrroles; Transforming Growth Factor beta

2019
Cancer-associated fibroblast regulate proliferation and migration of prostate cancer cells through TGF-β signaling pathway.
    Life sciences, 2019, Oct-15, Volume: 235

    Topics: Animals; Cancer-Associated Fibroblasts; Cell Movement; Cell Proliferation; Embryo, Nonmammalian; Gene Expression Regulation, Neoplastic; Humans; Male; Prostatic Neoplasms; Pyrazoles; Pyrroles; Receptors, Transforming Growth Factor beta; Signal Transduction; Transforming Growth Factor beta1; Tumor Cells, Cultured; Xenograft Model Antitumor Assays; Zebrafish

2019
Cathelicidin-related antimicrobial peptide protects against cardiac fibrosis in diabetic mice heart by regulating endothelial-mesenchymal transition.
    International journal of biological sciences, 2019, Volume: 15, Issue:11

    Topics: AMP-Activated Protein Kinases; Animals; Antimicrobial Cationic Peptides; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Echocardiography; Endothelial Cells; Endothelium; Epithelial-Mesenchymal Transition; Fibrosis; Glucose; Hemodynamics; Hyperglycemia; Male; Mice; Mice, Inbred C57BL; Pyrazoles; Pyrroles; Signal Transduction; Transforming Growth Factor beta

2019
TGF-β receptor inhibitor LY2109761 enhances the radiosensitivity of gastric cancer by inactivating the TGF-β/SMAD4 signaling pathway.
    Aging, 2019, 10-19, Volume: 11, Issue:20

    Topics: Animals; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Humans; Male; Mice, Nude; Neoplasms, Experimental; Pyrazoles; Pyrroles; Radiation Tolerance; Signal Transduction; Smad4 Protein; Stomach Neoplasms; Transforming Growth Factor beta

2019
Development of a Tumor-Responsive Nanopolyplex Targeting Pancreatic Cancer Cells and Stroma.
    ACS applied materials & interfaces, 2019, Dec-11, Volume: 11, Issue:49

    Topics: Animals; Caprylates; Cell Line, Tumor; Cell Proliferation; Humans; Hydrophobic and Hydrophilic Interactions; Mice; Nanoparticles; Pancreatic Neoplasms; Pancreatic Stellate Cells; Pyrazoles; Pyrroles; Stromal Cells; Sulfides; Tumor Microenvironment; Xenograft Model Antitumor Assays

2019
TGFβ1 alleviates axonal injury by regulating microglia/macrophages alternative activation in traumatic brain injury.
    Brain research bulletin, 2020, Volume: 161

    Topics: Animals; Axons; Brain Injuries, Traumatic; Macrophages; Male; Microglia; Pyrazoles; Pyrroles; Rats; Rats, Sprague-Dawley; Transforming Growth Factor beta1

2020
Destruction of the blood-retina barrier in diabetic retinopathy depends on angiotensin-converting enzyme-mediated TGF-β1/Smad signaling pathway activation.
    International immunopharmacology, 2020, Volume: 85

    Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Cells, Cultured; Coculture Techniques; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Endothelial Cells; Ependymoglial Cells; Fosinopril; Male; Peptidyl-Dipeptidase A; Pyrazoles; Pyrroles; Rats; Rats, Sprague-Dawley; Retina; Signal Transduction; Smad Proteins; Transforming Growth Factor beta1

2020
Effects of tacrolimus on the TGF‑β1/SMAD signaling pathway in paraquat‑exposed rat alveolar type II epithelial cells.
    Molecular medicine reports, 2020, Volume: 22, Issue:5

    Topics: Alveolar Epithelial Cells; Animals; Cell Line; Cell Proliferation; Cell Survival; Herbicides; Immunosuppressive Agents; Paraquat; Pulmonary Fibrosis; Pyrazoles; Pyrroles; Rats; Receptor, Transforming Growth Factor-beta Type I; Receptor, Transforming Growth Factor-beta Type II; Signal Transduction; Smad3 Protein; Smad7 Protein; Tacrolimus; Transforming Growth Factor beta1

2020
A novel approach for monitoring TGF-β signaling in vivo in colon cancer.
    Carcinogenesis, 2021, 04-30, Volume: 42, Issue:4

    Topics: Animals; Benzamides; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Dioxoles; Disease Models, Animal; Humans; Mice; Protein Kinase Inhibitors; Pyrazoles; Pyrroles; Receptors, Transforming Growth Factor beta; Signal Transduction; Transforming Growth Factor beta

2021
Moderate oxidative stress promotes epithelial-mesenchymal transition in the lens epithelial cells via the TGF-β/Smad and Wnt/β-catenin pathways.
    Molecular and cellular biochemistry, 2021, Volume: 476, Issue:3

    Topics: Animals; Antioxidants; beta Catenin; Capsule Opacification; Cataract; Cell Proliferation; Cell Survival; Disease Models, Animal; Epithelial Cells; Epithelial-Mesenchymal Transition; Fibrosis; Humans; Lens, Crystalline; Mice; Oxidative Stress; Oxygen; Pyrazoles; Pyrroles; Swine; Transforming Growth Factor beta; Transforming Growth Factor beta1; Tropicamide; Wnt Signaling Pathway

2021
Bone marrow mesenchymal stem cells in microenvironment transform into cancer-associated fibroblasts to promote the progression of B-cell acute lymphoblastic leukemia.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020, Volume: 130

    Topics: Benzylamines; Cancer-Associated Fibroblasts; Cell Line, Tumor; Chemokine CXCL12; Cyclams; Disease Progression; Humans; Mesenchymal Stem Cells; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Pyrazoles; Pyrroles; Receptors, CXCR4; Signal Transduction; Transforming Growth Factor beta; Tumor Microenvironment

2020
TGF-β-Induced FLRT3 Attenuation Is Essential for Cancer-Associated Fibroblast-Mediated Epithelial-Mesenchymal Transition in Colorectal Cancer.
    Molecular cancer research : MCR, 2022, 08-05, Volume: 20, Issue:8

    Topics: Antigens, CD; Cadherins; Cancer-Associated Fibroblasts; Cell Line, Tumor; Cell Movement; Colorectal Neoplasms; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Humans; Membrane Glycoproteins; Pyrazoles; Pyrroles; Signal Transduction; Transforming Growth Factor beta; Tumor Microenvironment

2022