Page last updated: 2024-08-18

pyrroles and luotonin a

pyrroles has been researched along with luotonin a in 36 studies

Research

Studies (36)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	15 (41.67)	29.6817
2010's	17 (47.22)	24.3611
2020's	4 (11.11)	2.80

Authors

Authors	Studies
Cagir, A; Eisenhauer, BM; Gao, R; Hecht, SM; Jones, SH	2
Argade, NP; Mhaske, SB	1
Beretta, GL; Dallavalle, S; Merlini, L; Tinelli, S; Zunino, F	1
Cagir, A; Eisenhauer, BM; Gao, R; Hecht, SM; Thomas, SJ	1
Cheng, K; Eisenhauer, BM; Gao, R; Hecht, SM; Rahier, NJ; Thomas, SJ	1
Bowman, WR; Cloonan, MO; Fletcher, AJ; Stein, T	1
Azzouz, M; Courillon, C; Lopes, D; Malacria, M; Servais, A	1
Bowman, WR; Elsegood, MR; Stein, T; Weaver, GW	1
Friedrich, TD; Guzzo, PR; Jason Herr, R; Nacro, K; Peace, D; Zha, CC	1
Liu, GS; Yao, ZJ; Zhou, HB	1
Bergman, J; Mason, JJ	1
Jahng, KC; Jahng, Y; Kim, DH; Kim, SI; Lee, ES; Lee, SH; Seo, CS; Son, JK	1
Menéndez, JC; Ramos, MT; Ribelles, P; Sridharan, V	1
Ju, Y; Li, C; Liu, F	1
Corda, E; Girotti, S; González-Ruiz, V; Martín, MA; Mussardo, P; Olives, AI	1
Corda, E; Girotti, S; González-Ruiz, V; Martín, MA; Mussardo, P; Olives, AI; Rajesh, J	1
Chu, YH; Chu, YW; Hwang, J; Lin, CM; Tsai, HP; Tseng, MC	1
Haider, N; Nuß, S	1
Jahng, Y; Jeong, TC; Kim, DH; Lee, J; Lee, S	1
Jahng, Y; Kwon, OK; Lee, S	1
Biczók, L; Miskolczy, Z	1
Bianchini, G; Fernández-Marcelo, T; González-Ruiz, V; Iniesta, P; Martín, MA; Menéndez, JC; Olives, AI; Pascua, I; Ramos, MT; Ribelles, P; Sridharan, V	1
Bantu, R; Bhadra, M; Gaikwad, HK; Ganesh, AR; Janardhan, S; Nagarapu, L; Ramaiah, MJ; Sastry, GN; Venkatesh, R	1
Walton, JC	1
Anitha, K; Kesavan, MP; Kumar, GGV; Raja, JD; Rajagopal, G; Rajesh, J; Ravi, L	1
Almansour, AI; Altaf, M; Arumugam, N; Bianchini, G; Ghabbour, HA; Mahalingam, SM; Menéndez, JC; Sau, S; Suresh Kumar, R	1
Dutter, K; Haider, N; Ibric, A; Marian, B	1
Ayyanaar, S; Dhaveethu Raja, J; Kesavan, MP; Lenin, N; Rajesh, J; Sankarganesh, M	1
Ayyanaar, S; Kesavan, MP; Kotla, NG; Kumar, GGV; Rajagopal, G; Rajesh, J; Sivaraman, G; Webster, TJ	1
Eckerstorfer, S; Eder, M; Haider, N; Heffeter, P; Ibric, A; Louko, I; Marian, B; Schueffl, HH; Tunjic, L	1
Almansour, AI; Altaf, M; Arumugam, N; Bianchini, G; Dupadahalli, K; Kumar, RS; Menéndez, JC; Mohammad, F	1
Battisti, V; Deckardt, S; Haider, N; Haller, AV; Heffeter, P; Ibric, A; Langer, T; Lee, C; Marian, B; Prötsch, C; Schueffl, HH	1
Li, JC; Liu, YQ; Ma, KY; Peng, JW; Shang, XF; Wang, RX; Yang, GZ; Zhang, J; Zhang, ZJ; Zhao, WB; Zhao, ZM	1
Agama, K; Golen, JA; Murphy, ZF; Pommier, Y; Rasapalli, S; Sammeta, VR; Savinov, SN	1
Chen, A; Dong, W; Fan, S; Liang, C; Wu, F; Yin, Z; Yuan, Y; Zhang, Z	1

Reviews

1 review(s) available for pyrroles and luotonin a

Article	Year
Synthetic Strategies for 5- and 6-Membered Ring Azaheterocycles Facilitated by Iminyl Radicals. Molecules (Basel, Switzerland), 2016, May-18, Volume: 21, Issue:5 Topics: Catalysis; Cyclization; Dioxoles; Free Radicals; Indole Alkaloids; Oximes; Phenanthridines; Pyridines; Pyrroles; Quinazolines; Quinones	2016

Other Studies

35 other study(ies) available for pyrroles and luotonin a

Article	Year
Luotonin A. A naturally occurring human DNA topoisomerase I poison. Journal of the American Chemical Society, 2003, Nov-12, Volume: 125, Issue:45 Topics: Alkaloids; Antineoplastic Agents, Phytogenic; Camptothecin; DNA; DNA Topoisomerases, Type I; Enzyme Inhibitors; Humans; Pyrroles; Quinones; Topoisomerase I Inhibitors	2003
Synthesis and biochemical properties of E-ring modified luotonin A derivatives. Bioorganic & medicinal chemistry letters, 2004, May-03, Volume: 14, Issue:9 Topics: Enzyme Inhibitors; Humans; Pyrroles; Quinones; Topoisomerase I Inhibitors	2004
Regioselective quinazolinone-directed ortho lithiation of quinazolinoylquinoline: practical synthesis of naturally occurring human DNA topoisomerase I poison luotonin a and luotonins B and E. The Journal of organic chemistry, 2004, Jun-25, Volume: 69, Issue:13 Topics: Enzyme Inhibitors; Humans; Lithium; Molecular Structure; Pyrroles; Quinazolines; Quinones; Stereoisomerism; Topoisomerase I Inhibitors	2004
Synthesis and cytotoxic activity of substituted luotonin A derivatives. Bioorganic & medicinal chemistry letters, 2004, Dec-06, Volume: 14, Issue:23 Topics: Cell Line, Tumor; DNA Topoisomerases, Type I; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Pyrroles; Quinones; Topoisomerase I Inhibitors	2004
Synthesis and topoisomerase I inhibitory properties of luotonin A analogues. Bioorganic & medicinal chemistry, 2004, Dec-01, Volume: 12, Issue:23 Topics: DNA; DNA Topoisomerases, Type I; Humans; Organisms, Genetically Modified; Pyrroles; Quinones; Saccharomyces cerevisiae; Solvents; Structure-Activity Relationship; Topoisomerase I Inhibitors	2004
14-azacamptothecin: a potent water-soluble topoisomerase I poison. Journal of the American Chemical Society, 2005, Jan-26, Volume: 127, Issue:3 Topics: Camptothecin; Enzyme Inhibitors; Humans; Kinetics; Pyrroles; Quinones; Solubility; Topoisomerase I Inhibitors; Water	2005
Synthesis of heteroarenes using cascade radical cyclisation via iminyl radicals. Organic & biomolecular chemistry, 2005, Apr-21, Volume: 3, Issue:8 Topics: Alkaloids; Cyclization; Free Radicals; Imides; Indolizines; Molecular Structure; Pyrroles; Quinolines; Quinones	2005
Radical cyclization of N-acylcyanamides: total synthesis of luotonin A. Angewandte Chemie (International ed. in English), 2007, Volume: 46, Issue:4 Topics: Cyanamide; Cyclization; Pyrroles; Quinones	2007
Radical reactions with 3H-quinazolin-4-ones: synthesis of deoxyvasicinone, mackinazolinone, luotonin A, rutaecarpine and tryptanthrin. Organic & biomolecular chemistry, 2007, Jan-07, Volume: 5, Issue:1 Topics: Alkaloids; Cyclization; Free Radicals; Indole Alkaloids; Molecular Structure; Pyrroles; Quinazolines; Quinazolinones; Quinones	2007
Synthesis and topoisomerase poisoning activity of A-ring and E-ring substituted luotonin A derivatives. Bioorganic & medicinal chemistry, 2007, Jun-15, Volume: 15, Issue:12 Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Enzyme Inhibitors; Humans; Magnetic Resonance Spectroscopy; Pyrroles; Quinones; Spectrometry, Mass, Electrospray Ionization; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors	2007
Short and efficient total synthesis of luotonin A and 22-hydroxyacuminatine using a common cascade strategy. The Journal of organic chemistry, 2007, Aug-03, Volume: 72, Issue:16 Topics: Camptothecin; Chemistry, Organic; Fluorenes; Indolizines; Models, Chemical; Molecular Conformation; Pyrroles; Quinolines; Quinones	2007
Total synthesis of luotonin A and 14-substituted analogues. Organic & biomolecular chemistry, 2007, Aug-07, Volume: 5, Issue:15 Topics: Chlorine; Molecular Structure; Pyrroles; Quinones	2007
One-pot synthesis of simple alkaloids: 2,3-polymethylene-4(3H)-quinazolinones, luotonin A, tryptanthrin, and rutaecarpine. Chemical & pharmaceutical bulletin, 2008, Volume: 56, Issue:4 Topics: Chemical Phenomena; Chemistry, Physical; Indicators and Reagents; Indole Alkaloids; Lactams; Magnetic Resonance Spectroscopy; ortho-Aminobenzoates; Pyrroles; Quinazolines; Quinazolinones; Quinones; Spectrophotometry, Infrared	2008
Cerium(IV) ammonium nitrate is an excellent, general catalyst for the Friedländer and Friedländer-Borsche quinoline syntheses: very efficient access to the antitumor alkaloid luotonin A. The Journal of organic chemistry, 2009, Aug-07, Volume: 74, Issue:15 Topics: Alkaloids; Antineoplastic Agents; Catalysis; Cerium; Molecular Structure; Nitrates; Pyrroles; Quinones; Stereoisomerism	2009
Palladium-catalyzed sequential cyanation/n-addition/N-arylation in one-pot: efficient synthesis of luotonin A and its derivatives. Organic letters, 2009, Aug-20, Volume: 11, Issue:16 Topics: Catalysis; Combinatorial Chemistry Techniques; Molecular Structure; Palladium; Pyrroles; Quinones	2009
Liquid chromatographic analysis of the anticancer alkaloid luotonin A and some new derivatives in human serum samples. Journal of separation science, 2010, Volume: 33, Issue:14 Topics: Alkaloids; Animals; Antineoplastic Agents; Camptothecin; Chromatography, Liquid; Humans; Molecular Structure; Pyrroles; Quinones; Reproducibility of Results	2010
Study of non-covalent interactions of luotonin A derivatives and the DNA minor groove as a first step in the study of their analytical potential as DNA probes. Analytical and bioanalytical chemistry, 2011, Volume: 400, Issue:2 Topics: DNA Probes; DNA, Single-Stranded; Intercalating Agents; Kinetics; Nucleic Acid Conformation; Pyrroles; Quinones	2011
One-pot synthesis of luotonin A and its analogues. Organic letters, 2011, Mar-04, Volume: 13, Issue:5 Topics: DNA Topoisomerases, Type I; Humans; Molecular Structure; Peganum; Pyrroles; Quinazolines; Quinolines; Quinones; Topoisomerase I Inhibitors	2011
Weinreb amidation as the cornerstone of an improved synthetic route to A-ring-modified derivatives of luotonin A. Molecules (Basel, Switzerland), 2012, Sep-25, Volume: 17, Issue:10 Topics: Decarboxylation; Hydrolysis; Pyrroles; Quinones	2012
Characterization of in vitro metabolites of luotonin A in human liver microsomes using electrospray/tandem mass spectrometry. Xenobiotica; the fate of foreign compounds in biological systems, 2013, Volume: 43, Issue:6 Topics: Biotransformation; Camptothecin; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; DNA, Complementary; Enzyme Inhibitors; Humans; Hydroxylation; Isoenzymes; Metabolic Networks and Pathways; Microsomes, Liver; Molecular Weight; Protons; Pyrroles; Quinones; Recombinant Proteins; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry	2013
In vitro inhibitory effect of luotonin A on human CYP1A. Archives of pharmacal research, 2012, Volume: 35, Issue:12 Topics: Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Enzyme Inhibitors; Humans; Microsomes, Liver; Pyrroles; Quinones	2012
Effect of hydrogen bonding and complexation with metal ions on the fluorescence of luotonin A. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2013, Volume: 12, Issue:5 Topics: Cadmium; Coordination Complexes; Hydrogen Bonding; Ions; Metals; Propanols; Pyrroles; Quinones; Silver; Solvents; Spectrometry, Fluorescence; Zinc	2013
B-ring-aryl substituted luotonin A analogues with a new binding mode to the topoisomerase 1-DNA complex show enhanced cytotoxic activity. PloS one, 2014, Volume: 9, Issue:5 Topics: Amino Acids; Antineoplastic Agents; Camptothecin; Cerium; Chemistry, Pharmaceutical; Crystallization; DNA; DNA Topoisomerases, Type I; HeLa Cells; Humans; Hydrogen Bonding; Ligands; Magnetic Resonance Spectroscopy; Molecular Conformation; Nitrates; Protein Binding; Pyrroles; Quinones; Topoisomerase I Inhibitors	2014
Luotonin-A based quinazolinones cause apoptosis and senescence via HDAC inhibition and activation of tumor suppressor proteins in HeLa cells. European journal of medicinal chemistry, 2015, Apr-13, Volume: 94 Topics: Apoptosis; Cell Cycle; Cellular Senescence; Click Chemistry; Enhancer of Zeste Homolog 2 Protein; HeLa Cells; Histone Deacetylase 1; Histone Deacetylase 2; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Inhibitory Concentration 50; K562 Cells; MCF-7 Cells; Molecular Docking Simulation; Polycomb Repressive Complex 2; Pyrroles; Quinazolinones; Quinones; Tumor Suppressor Protein p53; Tumor Suppressor Proteins	2015
Natural alkaloid Luotonin A and its affixed acceptor molecules: Serum albumin binding studies. Journal of photochemistry and photobiology. B, Biology, 2017, Volume: 173 Topics: Alkaloids; Animals; Binding Sites; Cattle; Fluorescence Resonance Energy Transfer; Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Kinetics; Molecular Docking Simulation; Protein Binding; Protein Structure, Tertiary; Pyrroles; Quinones; Serum Albumin; Serum Albumin, Bovine; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Thermodynamics	2017
Design, synthesis and antiproliferative activity of decarbonyl luotonin analogues. European journal of medicinal chemistry, 2017, Sep-29, Volume: 138 Topics: Antineoplastic Agents; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Pyrroles; Quinones; Structure-Activity Relationship; Tumor Cells, Cultured	2017
A Facile Oxidative Opening of the C-Ring in Luotonin A and Derivatives. Molecules (Basel, Switzerland), 2017, Sep-12, Volume: 22, Issue:9 Topics: Antineoplastic Agents; Cell Line, Tumor; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Structure; Oxidation-Reduction; Pyrroles; Quinones	2017
One pot synthesis of new poly(vinyl alcohol) blended natural polymer based magnetic hydrogel beads: Controlled natural anticancer alkaloid delivery system. Journal of biomedical materials research. Part A, 2018, Volume: 106, Issue:2 Topics: Alkaloids; Antineoplastic Agents; Chitosan; Delayed-Action Preparations; Diffusion; Drug Delivery Systems; Drug Liberation; HeLa Cells; Humans; Hydrogels; Kinetics; Magnetics; Magnetite Nanoparticles; MCF-7 Cells; Microspheres; Polyvinyl Alcohol; Pyrroles; Quinones; Spectrometry, X-Ray Emission; Spectroscopy, Fourier Transform Infrared; Thermogravimetry; Water; X-Ray Diffraction	2018
A theranostic nanocomposite system based on iron oxide-drug nanocages for targeted magnetic field responsive chemotherapy. Nanomedicine : nanotechnology, biology, and medicine, 2018, Volume: 14, Issue:5 Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Cell Proliferation; Drug Delivery Systems; Ferric Compounds; HeLa Cells; Humans; Magnetic Fields; MCF-7 Cells; Nanocomposites; Neoplasms; Pyrroles; Quinones; Theranostic Nanomedicine	2018
Position-Selective Synthesis and Biological Evaluation of Four Isomeric A-Ring Amino Derivatives of the Alkaloid Luotonin A. Molecules (Basel, Switzerland), 2019, Feb-16, Volume: 24, Issue:4 Topics: Alkaloids; Antineoplastic Agents; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Survival; Chemistry Techniques, Synthetic; Humans; Magnetic Resonance Spectroscopy; Molecular Structure; Pyrroles; Quinones; Spectrometry, Mass, Electrospray Ionization; Structure-Activity Relationship; Topoisomerase I Inhibitors	2019
D-Ring-Modified Analogues of Luotonin A with Reduced Planarity: Design, Synthesis, and Evaluation of Their Topoisomerase Inhibition-Associated Cytotoxicity. BioMed research international, 2019, Volume: 2019 Topics: Alkaloids; Antineoplastic Agents; Camptothecin; Cell Line, Tumor; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Enzyme Inhibitors; Humans; Molecular Docking Simulation; Poly-ADP-Ribose Binding Proteins; Pyrroles; Quinones; Solubility; Structure-Activity Relationship; Topoisomerase Inhibitors	2019
A-ring and E-ring modifications of the cytotoxic alkaloid Luotonin A: Synthesis, computational and biological studies. Bioorganic & medicinal chemistry, 2020, 05-01, Volume: 28, Issue:9 Topics: Antineoplastic Agents; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Molecular Docking Simulation; Molecular Structure; Pyrroles; Quinones; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured	2020
Discovery of luotonin A analogues as potent fungicides and insecticides: Design, synthesis and biological evaluation inspired by natural alkaloid. European journal of medicinal chemistry, 2020, May-15, Volume: 194 Topics: Alkaloids; Animals; Aphids; Biological Products; Botrytis; Dose-Response Relationship, Drug; Drug Discovery; Fungicides, Industrial; Insecticides; Magnaporthe; Molecular Structure; Pyrroles; Quinones; Structure-Activity Relationship	2020
Design and synthesis of C-aryl angular luotonins via a one-pot aza-Nazarov-Friedlander sequence and their Topo-I inhibition studies along with C-aryl vasicinones and luotonins. Bioorganic & medicinal chemistry letters, 2021, 06-01, Volume: 41 Topics: Alkaloids; DNA Topoisomerases, Type I; Dose-Response Relationship, Drug; Drug Design; Humans; Molecular Structure; Pyrroles; Quinones; Structure-Activity Relationship; Topoisomerase I Inhibitors	2021
Rapid Synthesis of Luotonin A Derivatives via Synergistic Visible-Light Photoredox and Acid Catalysis. The Journal of organic chemistry, 2022, 01-21, Volume: 87, Issue:2 Topics: Catalysis; Cyclization; Molecular Structure; Oxidation-Reduction; Pyrroles; Quinones	2022