pyrroles has been researched along with leukotriene b4 in 20 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (20.00) | 18.2507 |
| 2000's | 12 (60.00) | 29.6817 |
| 2010's | 4 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chertock, H; Hamdan, A; Kimble, E; Kowalski, T; Lee, W; Neale, R; Pastor, G; Raychauduri, A; Wasley, J; White, D | 1 |
| Obata, Y; Oda, M; Yamamoto, N; Yokota, K | 2 |
| Berto, L; Bonnet, PA; Cortijo, J; Michel, A; Morcillo, EJ; Navarrete, C; Sanz, C; Villagrasa, V | 1 |
| Drutkowski, G; Fabian, J; Frohberg, P; Görlitzer, K | 1 |
| Laufer, S; Neupert, W; Tries, S | 1 |
| Lajeunesse, D; Laufer, S; Martel-Pelletier, J; Massicotte, F; Paredes, Y; Pelletier, JP | 1 |
| Barbanti, M; de Lima, OM; Distrutti, E; Fiorucci, S; Mencarelli, A; Morelli, A; Palazzini, E; Romano, M; Wallace, JL | 1 |
| Cirino, G; Distrutti, E; Fiorucci, S; Laufor, SA; Mencarelli, A; Morelli, A; Wallace, JL | 1 |
| Fernandes, JC; Lajeunesse, D; Laufer, S; Martel-Pelletier, J; Pelletier, JP | 1 |
| Guévremont, M; Laufer, S; Marcouiller, P; Martel-Pelletier, J; Pelletier, JP; Ranger, P; Reboul, P | 1 |
| Kulkarni, SK; Patil, CS; Singh, VP | 1 |
| Cerletti, C; Dell'Elba, G; Evangelista, V; Manarini, S; Rotondo, S | 1 |
| Egido, J; Gómez-Gerique, JA; Gómez-Hernández, A; González, A; Ortega, L; Sánchez-Galán, E; Tuñón, J; Vidal, C | 1 |
| Blanco-Colio, LM; Egido, J; Gómez-Hernández, A; Jiménez-Nacher, JJ; López-Bescos, L; Martín-Ventura, JL; Ortego, M; Sánchez-Galán, E; Tarín-Vicente, N; Tuñón, J | 1 |
| Birnbaum, Y; Lin, Y; Perez-Polo, JR; Tieu, BC; Uretsky, BF; Ye, Y; Ye, Z | 1 |
| Gao, Y; He, C; He, S; Lai, L; Liu, Y; Wu, Y | 1 |
| Guan, F; Ju, J; Li, G; Liu, AB; Sun, Y; Yang, CS; Yang, Z | 1 |
| Christensen, JH; Lundbye-Christensen, S; Lysgaard, C; Nielsen, MS; Riahi, S; Schmidt, EB | 1 |
| Dulin, JN; Grill, RJ; Karoly, ED; Strobel, HW; Wang, Y | 1 |
2 trial(s) available for pyrroles and leukotriene b4
| Article | Year |
|---|---|
Effect of intensive atorvastatin therapy on prostaglandin E2 levels and metalloproteinase-9 activity in the plasma of patients with non-ST-elevation acute coronary syndrome.
Topics: Acute Coronary Syndrome; Adult; Aged; Aged, 80 and over; Atorvastatin; Dinoprostone; Electrocardiography; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leukotriene B4; Male; Matrix Metalloproteinase 9; Middle Aged; NF-kappa B; Pyrroles; Treatment Outcome | 2008 |
No effect of high-dose atorvastatin on leukotriene B₄ formation from neutrophils in patients treated with coronary bypass surgery: a randomized placebo-controlled double-blinded trial with a crossover design.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Atorvastatin; Calcimycin; Calcium Ionophores; Cholesterol, LDL; Combined Modality Therapy; Coronary Artery Bypass; Coronary Disease; Cross-Over Studies; Double-Blind Method; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Leukotriene B4; Male; Middle Aged; Neutrophil Activation; Neutrophils; Pyrroles | 2012 |
18 other study(ies) available for pyrroles and leukotriene b4
| Article | Year |
|---|---|
CGS 22745: a selective orally active inhibitor of 5-lipoxygenase.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Biological Availability; Blood Platelets; Calcimycin; Dogs; Guinea Pigs; Half-Life; Humans; Hydroxamic Acids; In Vitro Techniques; Leukocytes; Leukotriene B4; Lipoxygenase Inhibitors; Neutrophils; Pleurisy; Pyrroles; Rats; Sheep | 1991 |
Inhibitory effect of KBT-3022, a new anti-platelet agent, on infiltration of polymorphonuclear leukocytes induced by leukotriene B4 or formyl-methionyl-leucyl-phenylalanine in mice.
Topics: Animals; Dexamethasone; Dose-Response Relationship, Drug; Indomethacin; Leukocytes; Leukotriene B4; Mice; Mice, Inbred Strains; N-Formylmethionine Leucyl-Phenylalanine; Platelet Aggregation Inhibitors; Pyrroles; Thiazoles | 1995 |
Inhibitory effects of the new anti-platelet agent KBT-3022 and its metabolite on rabbit neutrophil function in vitro.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Binding Sites; Calcium; Cell Adhesion; Cilostazol; Complement C3-C5 Convertases; Complement C5a; Cyclooxygenase Inhibitors; Indomethacin; Leukotriene B4; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Platelet Aggregation Inhibitors; Pyrroles; Rabbits; Structure-Activity Relationship; Superoxides; Tetradecanoylphorbol Acetate; Tetrazoles; Thiazoles; Ticlopidine | 1996 |
Effects of SCA40 on human isolated bronchus and human polymorphonuclear leukocytes: comparison with rolipram, SKF94120 and levcromakalim.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Anti-Inflammatory Agents, Non-Steroidal; Benzopyrans; Bronchi; Bronchodilator Agents; Calcium; Cardiotonic Agents; Cromakalim; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclic Nucleotide Phosphodiesterases, Type 5; Humans; Imidazoles; In Vitro Techniques; Leukocyte Elastase; Leukotriene B4; Muscle Relaxation; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphoric Diester Hydrolases; Pyrazines; Pyrroles; Pyrrolidinones; Rolipram; Superoxides | 1996 |
[Pyrrolo(2,3-c)quinolines and pyrrolo(3,4-d)quinolines--synthesis and investigation of lipoxygenase inhibition].
Topics: Arachidonate 5-Lipoxygenase; Humans; Hydroxamic Acids; In Vitro Techniques; Leukotriene B4; Lipoxygenase Inhibitors; Neutrophils; Pyrroles; Quinolines | 2002 |
The mechanism of action of the new antiinflammatory compound ML3000: inhibition of 5-LOX and COX-1/2.
Topics: Acetates; Adult; Animals; Anti-Inflammatory Agents, Non-Steroidal; Colon; Cyclooxygenase Inhibitors; Edema; Gastric Mucosa; Humans; Leukotriene B4; Leukotriene C4; Lipoxygenase Inhibitors; Male; Pyrroles; Rats; Rats, Sprague-Dawley; Rats, Wistar; Stomach; Thromboxane B2 | 2002 |
Study of the role of leukotriene B()4 in abnormal function of human subchondral osteoarthritis osteoblasts: effects of cyclooxygenase and/or 5-lipoxygenase inhibition.
Topics: Acetates; Alkaline Phosphatase; Blotting, Western; Cyclooxygenase Inhibitors; Dinoprostone; Female; Humans; In Vitro Techniques; Leukotriene B4; Lipoxygenase Inhibitors; Male; Middle Aged; Nitrobenzenes; Osteoarthritis; Osteoblasts; Osteocalcin; Pyrroles; Quinolines; Sulfonamides | 2002 |
Relative contribution of acetylated cyclo-oxygenase (COX)-2 and 5-lipooxygenase (LOX) in regulating gastric mucosal integrity and adaptation to aspirin.
Topics: Acetates; Acetylation; Adaptation, Physiological; Animals; Arachidonate 5-Lipoxygenase; Aspirin; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Gastric Mucosa; Hydroxyeicosatetraenoic Acids; Isoenzymes; Leukotriene B4; Lipoxins; Lipoxygenase Inhibitors; Models, Biological; Prostaglandin-Endoperoxide Synthases; Pyrroles; Rats | 2003 |
Evidence that 5-lipoxygenase and acetylated cyclooxygenase 2-derived eicosanoids regulate leukocyte-endothelial adherence in response to aspirin.
Topics: Acetates; Acetylation; Adhesiveness; Arachidonate 5-Lipoxygenase; Aspirin; CD11a Antigen; Cells, Cultured; Cyclooxygenase 2; Dose-Response Relationship, Drug; E-Selectin; Eicosanoids; Endothelial Cells; Endothelium, Vascular; Fatty Alcohols; Glycols; Humans; Isoenzymes; Leukocytes; Leukotriene B4; Lipopolysaccharides; Lipoxins; Lipoxygenase; Membrane Proteins; Neutrophils; Prostaglandin-Endoperoxide Synthases; Prostaglandins E; Pyrans; Pyrroles; Quinolines; Quinolones; Umbilical Cord; Up-Regulation | 2003 |
Treatment with licofelone prevents abnormal subchondral bone cell metabolism in experimental dog osteoarthritis.
Topics: Acetates; Animals; Antirheumatic Agents; Arthritis, Experimental; Cells, Cultured; Cyclooxygenase Inhibitors; Dinoprostone; Dogs; Enzyme Inhibitors; Insulin-Like Growth Factor I; Leukotriene B4; Lipoxygenase Inhibitors; Osteoarthritis; Osteoblasts; Pyrroles; Urokinase-Type Plasminogen Activator | 2004 |
Leukotriene and prostaglandin synthesis pathways in osteoarthritic synovial membranes: regulating factors for interleukin 1beta synthesis.
Topics: Acetates; Aged; Arachidonic Acid; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Drug Combinations; Female; Humans; In Vitro Techniques; Leukotriene B4; Lipopolysaccharides; Male; Masoprocol; Naproxen; Osteoarthritis, Knee; Pyrroles; Signal Transduction; Synovial Membrane | 2005 |
Effect of licofelone against NSAIDs-induced gastrointestinal ulceration and inflammation.
Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Female; Humans; Indomethacin; Inflammation; Leukotriene B4; Lipid Peroxidation; Male; Mesentery; Mice; Neutrophils; Pyrroles; Rats; Stomach Ulcer; Time Factors | 2005 |
The lipoxygenase-cyclooxygenase inhibitor licofelone prevents thromboxane A2-mediated cardiovascular derangement triggered by the inflammatory peptide fMLP in the rabbit.
Topics: Acetates; Animals; Aspirin; Blood Pressure; Cyclooxygenase Inhibitors; Disease Models, Animal; Electrocardiography; Heart Rate; Inflammation; Lactones; Leukotriene B4; Lipoxygenase Inhibitors; Male; Myocardial Ischemia; N-Formylmethionine Leucyl-Phenylalanine; Pyrroles; Rabbits; Sulfones; Thromboxane A2; Time Factors | 2006 |
Licofelone, a balanced inhibitor of cyclooxygenase and 5-lipoxygenase, reduces inflammation in a rabbit model of atherosclerosis.
Topics: Acetates; Animals; Atherosclerosis; Chemokine CCL2; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Leukotriene B4; Lipids; Lipoxygenase Inhibitors; Macrophages; Male; NF-kappa B; Pyrroles; Rabbits; RNA, Messenger; Thromboxane B2; Tunica Intima | 2007 |
Phosphorylation of 5-lipoxygenase at ser523 by protein kinase A determines whether pioglitazone and atorvastatin induce proinflammatory leukotriene B4 or anti-inflammatory 15-epi-lipoxin a4 production.
Topics: Animals; Arachidonate 5-Lipoxygenase; Atorvastatin; Cyclic AMP-Dependent Protein Kinases; Gene Expression Regulation; Heptanoic Acids; Immunologic Factors; Isoquinolines; Leukotriene B4; Lipoxins; Male; Myocardium; Phosphorylation; Pioglitazone; Pyrroles; Rats; Rats, Sprague-Dawley; Serine; Sulfonamides; Thiazolidinediones | 2008 |
Dynamic modeling of human 5-lipoxygenase-inhibitor interactions helps to discover novel inhibitors.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Cell-Free System; Databases, Factual; Dinoprostone; Humans; Intramolecular Oxidoreductases; Leukotriene B4; Lipoxygenase Inhibitors; Microsomes; Molecular Dynamics Simulation; Prostaglandin-E Synthases; Protein Binding; Protein Conformation; Pyrroles; Recombinant Proteins; Structure-Activity Relationship | 2012 |
Deleterious effects of high concentrations of (-)-epigallocatechin-3-gallate and atorvastatin in mice with colon inflammation.
Topics: Animals; Atorvastatin; Azoxymethane; Catechin; Colitis; Colon; Colonic Neoplasms; Dextran Sulfate; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Gastrointestinal Hemorrhage; Heptanoic Acids; Leukotriene B4; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Pyrroles; Rectum; Weight Loss | 2012 |
Licofelone modulates neuroinflammation and attenuates mechanical hypersensitivity in the chronic phase of spinal cord injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressure Liquid; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme-Linked Immunosorbent Assay; Female; Gas Chromatography-Mass Spectrometry; Hindlimb; Hot Temperature; Hyperalgesia; Inflammation; Leukotriene B4; Locomotion; Metabolomics; Oxidative Stress; Physical Stimulation; Pyrroles; Rats; Rats, Sprague-Dawley; Spinal Cord Injuries | 2013 |