pyrroles has been researched along with isoxazoles in 44 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (2.27) | 18.7374 |
| 1990's | 3 (6.82) | 18.2507 |
| 2000's | 10 (22.73) | 29.6817 |
| 2010's | 26 (59.09) | 24.3611 |
| 2020's | 4 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Fotsch, C; St Jean, DJ | 1 |
| Freeman, F; Kazan, BH; Wilson, PL | 1 |
| Cao, BJ; Rodgers, RJ | 1 |
| Bräuner-Osborne, H; Conti, P; De Amici, M; De Micheli, C; De Sarro, G; Madsen, U; Stensbøl, TB | 1 |
| Bräuner-Osborne, H; Conti, P; De Amici, M; De Micheli, C; De Sarro, G; Madsen, U; Rizzo, M; Stensbøl, TB; Toma, L | 1 |
| Baurin, N; Chavatte, P; Lesieur, D; Marot, C; Yous, S | 1 |
| Dalvie, DK; Kalgutkar, AS; Khojasteh-Bakht, SC; O'Donnell, JP; Obach, RS | 1 |
| Blaas, D; Kenndler, E; Nizet, S; Okun, VM | 1 |
| Barrett, JF; Bronson, JJ; D'Andrea, SV; DenBleyker, KL; Frosco, M; Fung-Tomc, JC; Gill, P; Marinier, A; Martel, A; Mate, R; Meng, Z; Quesnelle, CA; Snyder, LB | 1 |
| Birnbaum, Y; Hu, ZY; Rosanio, S; Schwarz, ER; Tavackoli, S; Uretsky, BF; Ye, Y | 1 |
| Bag, S; Degani, MS; Tawari, NR | 1 |
| Williams, M | 1 |
| Mahesh, K; Padmaja, A; Padmavathi, V; Radha Lakshmi, T | 1 |
| Hatanaka, M; Onitsuka, K; Sasai, H; Shinohara, T; Takenaka, K; Takizawa, S; Tsujihara, T | 1 |
| Gopalakrishnan, M; Hu, M; Li, J | 1 |
| Ahring, PK; Anderson, DJ; Briggs, CA; Bunnelle, WH; Dyhring, T; Gopalakrishnan, M; Gopalakrishnan, S; Grønlien, JH; Gubbins, E; Håkerud, M; Helfrich, R; Hu, M; Ji, J; Li, J; Malysz, J; Meyer, MD; Nielsen, EØ; Peters, D; Puttfarcken, PS; Thorin-Hagene, K; Timmermann, DB; Ween, H | 1 |
| Govardhan Reddy, K; Nagi Reddy, M; Rajanarendar, E; Raju, S; Siva Rami Reddy, A | 1 |
| Castellano, S; Conti, P; Pinto, A; Sbardella, G; Tamborini, L; Viviano, M | 1 |
| El-Sayed, M; Mikkelsen, JD; Thomsen, MS | 1 |
| Aritake, K; Hori, M; Matsuoka, T; Michishita, M; Murata, T; Narumiya, S; Ozaki, H; Tajima, T; Urade, Y | 1 |
| Anand, P; Singh, B | 2 |
| Anand, P; Badru, R; Singh, B | 1 |
| Abdurashid, A; Ali, T; Hudabergen, A; Imerhasan, M | 1 |
| Kawai, H; Okusu, S; Sato, H; Shibata, N; Shiro, M; Tokunaga, E | 1 |
| Jin, R; Sun, W; Tang, S | 1 |
| Bangalore, P; Gutte, SD; Mahajan, AA; Rane, RA; Sahu, NU; Shah, CP | 1 |
| Foley, P; Kelly, JB; Strober, BE | 1 |
| Li, T; Pan, F; Shu, C; Xiao, XY; Ye, LW; Zhou, AH | 1 |
| Azam, MA; Jubie, S; Thathan, J | 1 |
| Galenko, EE; Khlebnikov, AF; Novikov, MS; Tomashenko, OA | 1 |
| Adamo, MF; Disetti, P; Moccia, M; Salazar Illera, D; Suresh, S | 1 |
| Aminabhavi, TM; Dixit, SR; Joshi, SD; Kirankumar, MN; Lherbet, C; Narayan, R; Raju, KV; Yang, KS | 1 |
| Furukawa, S; Handa, H; Hashimoto, A; Hashimoto, S; Mikami, S; Oikawa, T; Okada, Y; Onodera, Y; Oya, M; Sabe, H; Sugino, H; Yoshikawa, A | 1 |
| Bao, N; Chen, L; Hu, J; Li, D; Shi, W; Sun, J | 1 |
| Xu, X; Zhang, D; Zhang, X | 1 |
| Bananis, E; Chen, C; Curtis, JR; Fan, H; Hirose, T; Lindsey, S; Mendelsohn, AM; Nduaka, CI; Tanaka, Y; Valdez, H; Wang, L; Winthrop, KL; Yamaoka, K | 1 |
| Alinari, L; Baiocchi, RA; Baskin, E; Beaver, L; Blachly, JS; Bollag, G; Brinton, L; Byrd, JC; Cannon, M; Carias, H; Dong, K; El-Gamal, D; Ewing, T; Goettl, VM; Grieselhuber, NR; Habets, G; Harrington, B; Hing, ZA; Ibrahim, P; Lai, TH; Lapalombella, R; Lehman, AM; Lucas, DM; Ma, Y; Marimuthu, A; Mathé, EA; Matusow, B; Mitchell, S; Nespi, M; Ozer, HG; Powell, B; Rezaei, H; Sampath, D; Sanftner, L; Severson, P; Shellooe, R; Shi, S; Spevak, W; Tantoy, C; Tsang, G; Walters, J; Williams, K; Woyach, JA; Yu, L; Zhang, C; Zhang, J; Zhang, Y | 1 |
| Chernysheva, NB; Demchuk, DV; Kiselyov, AS; Kislyi, VP; Konyushkin, LD; Maksimenko, AS; Raihstat, MM; Samet, AV; Semenov, VV; Semenova, MN; Silyanova, EA; Tsyganov, DV; Varakutin, AE | 1 |
| Chen, Y; Dou, G; Hu, F; Jiang, S; Li, J; Li, Y; Sheng, C; Wang, X; Wu, B; Zhang, Y; Zhao, G; Zhong, S | 1 |
| Aricioglu, F; Bekci, H; Cumaoglu, A; Unal, G; Yerer, MB | 1 |
| Aricioglu, F; Sirvanci, S; Unal, G | 1 |
| Galenko, EE; Khlebnikov, AF; Novikov, MS; Puzyk, AM | 1 |
| Fang, R; Kirillov, AM; Liu, K; Yang, L | 1 |
5 review(s) available for pyrroles and isoxazoles
| Article | Year |
|---|---|
Mitigating heterocycle metabolism in drug discovery.
Topics: Animals; Biotransformation; Databases, Factual; Drug Discovery; Drug Interactions; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds, 4 or More Rings; Humans; Mice; Pharmaceutical Preparations; Rats | 2012 |
Biotransformation reactions of five-membered aromatic heterocyclic rings.
Topics: Animals; Cytochrome P-450 Enzyme System; Furans; Heterocyclic Compounds, 4 or More Rings; Humans; Imidazoles; Indoles; Isoxazoles; Models, Chemical; Molecular Structure; Oxadiazoles; Oxazoles; Pyrazoles; Pyrroles; Tetrazoles; Thiadiazoles; Thiazoles; Thiophenes; Triazoles; Xenobiotics | 2002 |
Pyrrolo-isoxazole: a key molecule with diverse biological actions.
Topics: Acetylcholinesterase; Amnesia; Anti-Bacterial Agents; Bacteria; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Isoxazoles; Molecular Structure; Neuroprotective Agents; Pyrroles; Stress, Psychological; Structure-Activity Relationship | 2014 |
Current and future oral systemic therapies for psoriasis.
Topics: Acitretin; Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites; Cyclosporine; Fumarates; Humans; Hydroxyurea; Immunosuppressive Agents; Isoxazoles; Keratolytic Agents; Leflunomide; Methotrexate; Mycophenolic Acid; Piperidines; Protein Kinase Inhibitors; Psoriasis; Pyrimidines; Pyrroles; Sulfasalazine; Thalidomide; Thioguanine | 2015 |
Dual targeting DNA gyrase B (GyrB) and topoisomerse IV (ParE) inhibitors: A review.
Topics: Amino Acid Sequence; Aminopyridines; Anti-Bacterial Agents; Barbiturates; Benzimidazoles; DNA Gyrase; DNA Topoisomerase IV; Fluoroquinolones; Indazoles; Isoxazoles; Morpholines; Organophosphates; Oxazolidinones; Prodrugs; Pyrazoles; Pyrroles; Pyrrolidines; Pyrrolidinones; Quinazolinones; Quinolines; Spiro Compounds; Topoisomerase II Inhibitors; Topoisomerase Inhibitors; Urea | 2015 |
39 other study(ies) available for pyrroles and isoxazoles
| Article | Year |
|---|---|
Trypanosoma cruzi: antimicrobial activity and strain differentiating properties of some five- and six-membered heterocyclic compounds on trypomastigotes.
Topics: Furaldehyde; Furans; Isoxazoles; Ketones; Nitrofurans; Nitrofurantoin; Oximes; Pyrroles; Thiophenes; Trypanocidal Agents; Trypanosoma cruzi | 1975 |
Dopamine D4 receptor and anxiety: behavioural profiles of clozapine, L-745,870 and L-741,742 in the mouse plus-maze.
Topics: Animals; Anti-Anxiety Agents; Antipsychotic Agents; Anxiety; Chlordiazepoxide; Clozapine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Isoxazoles; Male; Maze Learning; Mice; Piperidines; Pyridines; Pyrroles; Receptors, Dopamine D4 | 1997 |
Synthesis and pharmacology of a new AMPA-kainate receptor agonist with potent convulsant activity.
Topics: Animals; Convulsants; Excitatory Amino Acid Agonists; Isoxazoles; Mice; Pyrroles; Receptors, AMPA; Receptors, Kainic Acid; Seizures; Stereoisomerism; Structure-Activity Relationship | 1998 |
Synthesis and enantiopharmacology of new AMPA-kainate receptor agonists.
Topics: Animals; Cerebral Cortex; Convulsants; Excitatory Amino Acid Agonists; In Vitro Techniques; Isoxazoles; Male; Mice; Mice, Inbred DBA; Models, Molecular; Molecular Conformation; Proline; Pyrroles; Radioligand Assay; Rats; Receptors, AMPA; Receptors, Kainic Acid; Stereoisomerism | 1999 |
Three-dimensional quantitative structure-activity relationships of cyclo-oxygenase-2 (COX-2) inhibitors: a comparative molecular field analysis.
Topics: Benzene Derivatives; Binding Sites; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cyclopentanes; Imidazoles; Isoenzymes; Isoxazoles; Models, Molecular; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Pyrroles; Quantitative Structure-Activity Relationship; Spiro Compounds; Thiophenes | 2001 |
Kinetics of thermal denaturation of human rhinoviruses in the presence of anti-viral capsid binders analyzed by capillary electrophoresis.
Topics: Antiviral Agents; Benzoates; Capsid; Electrophoresis, Capillary; Heating; HeLa Cells; Humans; Isoelectric Point; Isoxazoles; Kinetics; Pyrroles; Rhinovirus; Temperature; Time Factors | 2002 |
Discovery of isoxazolinone antibacterial agents. Nitrogen as a replacement for the stereogenic center found in oxazolidinone antibacterials.
Topics: Anti-Bacterial Agents; Gram-Negative Bacteria; Gram-Positive Bacteria; Isoxazoles; Microbial Sensitivity Tests; Models, Molecular; Nitrogen; Oxazolidinones; Oxazolone; Pyrroles; Stereoisomerism; Structure-Activity Relationship | 2004 |
Prostaglandins mediate the cardioprotective effects of atorvastatin against ischemia-reperfusion injury.
Topics: Animals; Atorvastatin; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme System; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; Intramolecular Oxidoreductases; Isoxazoles; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Phospholipases A; Phospholipases A2; Phosphorylation; Prostaglandin-E Synthases; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Pyrroles; Random Allocation; Rats; Rats, Sprague-Dawley; Sulfonamides | 2005 |
Pharmacophore mapping of a series of pyrrolopyrimidines, indolopyrimidines and their congeners as multidrug-resistance-associated protein (MRP1) modulators.
Topics: Computer Simulation; Humans; Hydrogen Bonding; Indoles; Inhibitory Concentration 50; Isoxazoles; Models, Molecular; Multidrug Resistance-Associated Proteins; Pyrimidines; Pyrroles; Quantitative Structure-Activity Relationship; Quinolones; Quinoxalines; Silymarin; Sulfonamides; Thiophenes | 2008 |
Commentary: genome-based CNS drug discovery: D-amino acid oxidase (DAAO) as a novel target for antipsychotic medications: progress and challenges.
Topics: Animals; Antipsychotic Agents; D-Amino-Acid Oxidase; Enzyme Activators; Genome, Human; Humans; Isoxazoles; Pyrazoles; Pyrroles; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Thiophenes | 2009 |
Synthesis and biological activity of a new class of sulfone-linked pyrrolylpyrazoles and pyrrolylisoxazoles from methyl-3-aryl-2-(E-arylethenesulfonyl)acrylate.
Topics: Acrylates; Anti-Bacterial Agents; Antifungal Agents; Cyanides; Isoxazoles; Microbial Sensitivity Tests; Pyrazoles; Pyrroles; Stereoisomerism; Structure-Activity Relationship; Sulfones | 2009 |
Enantioselective intramolecular oxidative aminocarbonylation of alkenylureas catalyzed by palladium-spiro bis(isoxazoline) complexes.
Topics: Alkenes; Amination; Catalysis; Isoxazoles; Ligands; Models, Chemical; Organometallic Compounds; Oxidation-Reduction; Palladium; Pyrimidines; Pyrroles; Spiro Compounds; Stereoisomerism; Urea | 2009 |
Positive allosteric modulation of alpha7 neuronal nicotinic acetylcholine receptors: lack of cytotoxicity in PC12 cells and rat primary cortical neurons.
Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Calcium; Cell Survival; Electrophysiology; Isoxazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neurites; Neurons; Nicotinic Agonists; PC12 Cells; Phenylurea Compounds; Phosphorylation; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Sulfonamides | 2009 |
In vitro pharmacological characterization of a novel selective alpha7 neuronal nicotinic acetylcholine receptor agonist ABT-107.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Calcium; Cell Line; Cells, Cultured; Cerebral Cortex; Electrophysiology; Excitatory Amino Acid Antagonists; Extracellular Signal-Regulated MAP Kinases; Humans; Indoles; Isoxazoles; Male; Nicotinic Agonists; Oocytes; Patch-Clamp Techniques; PC12 Cells; Phenylurea Compounds; Phosphorylation; Pyrroles; Quinuclidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Substrate Specificity; Sulfonamides; Xenopus | 2010 |
A fast and highly efficient protocol for synthesis of pyrrolo[2,3-d]isoxazoles and a new series of novel benzyl bis-pyrrolo[2,3-d]isoxazoles using task-specific ionic liquids as catalyst and green solvent.
Topics: Catalysis; Green Chemistry Technology; Ionic Liquids; Isoxazoles; Oxidation-Reduction; Pyrroles | 2010 |
Synthesis of 3-aryl/benzyl-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole derivatives: a comparison between conventional, microwave-assisted and flow-based methodologies.
Topics: Bridged Bicyclo Compounds, Heterocyclic; Isoxazoles; Microwaves; Nitriles; Pyrroles | 2010 |
Differential immediate and sustained memory enhancing effects of alpha7 nicotinic receptor agonists and allosteric modulators in rats.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; GPI-Linked Proteins; In Situ Hybridization; Intracellular Signaling Peptides and Proteins; Isoxazoles; Male; Memory; Memory, Short-Term; Nicotinic Agonists; Nicotinic Antagonists; Phenylurea Compounds; Pyridazines; Pyrroles; Rats; Rats, Wistar; Receptors, Nicotinic; RNA, Messenger | 2011 |
EP2 and EP4 receptors on muscularis resident macrophages mediate LPS-induced intestinal dysmotility via iNOS upregulation through cAMP/ERK signals.
Topics: Animals; Carbazoles; Cell Line; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Flavonoids; Gastrointestinal Motility; Ileum; Isoxazoles; Lipopolysaccharides; Macrophages; Male; Mice; Nitric Oxide Synthase Type II; Pyrroles; Receptors, Prostaglandin E, EP2 Subtype; Receptors, Prostaglandin E, EP4 Subtype; Sulfones; Up-Regulation | 2012 |
Synthesis and evaluation of novel 4-[(3H,3aH,6aH)-3-phenyl)-4,6-dioxo-2-phenyldihydro-2H-pyrrolo[3,4-d]isoxazol-5(3H,6H,6aH)-yl]benzoic acid derivatives as potent acetylcholinesterase inhibitors and anti-amnestic agents.
Topics: Acetylcholinesterase; Animals; Benzoates; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Computer Simulation; Cyclization; Enzyme Activation; Female; Humans; Isoxazoles; Male; Maze Learning; Memory; Mice; Neuroprotective Agents; Pyrroles; Rats; Stereoisomerism | 2012 |
Synthesis and evaluation of hexahydropyrrolo[3,4-d]isoxazole-4,6-diones as anti-stress agents.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Immobilization; Isoxazoles; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; Molecular Structure; Pyrroles; Spectroscopy, Fourier Transform Infrared; Stress, Physiological | 2012 |
[Inhibitory activity of dioxy-pyrrolino [3', 4'-d]isoxazoline derivatives containing (1', 2'-O-cyclohexylidendioxyethyl) against Cdc25A and CD45].
Topics: Antineoplastic Agents; cdc25 Phosphatases; Isoxazoles; Leukocyte Common Antigens; Pyrroles; Structure-Activity Relationship | 2011 |
Organocatalytic asymmetric synthesis of trifluoromethyl-substituted diarylpyrrolines: enantioselective conjugate cyanation of β-aryl-β-trifluoromethyl-disubstituted enones.
Topics: Catalysis; Crystallography, X-Ray; Cyanates; Hydrocarbons, Fluorinated; Isoxazoles; Molecular Structure; Pyrroles; Stereoisomerism | 2012 |
A DFT study of pyrrole-isoxazole derivatives as chemosensors for fluoride anion.
Topics: Fluorescent Dyes; Fluorides; Isoxazoles; Models, Molecular; Pyrroles; Quantum Theory; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Thiophenes | 2012 |
Synthesis and evaluation of novel marine bromopyrrole alkaloid-based hybrids as anticancer agents.
Topics: Alkaloids; Animals; Antineoplastic Agents; Caco-2 Cells; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chalcone; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Flavones; Humans; Inhibitory Concentration 50; Isoxazoles; Marine Biology; MCF-7 Cells; Models, Chemical; Molecular Structure; Pyrroles | 2013 |
Atom-Economic Synthesis of Fully Substituted 2-Aminopyrroles via Gold-Catalyzed Formal [3+2] Cycloaddition between Ynamides and Isoxazoles.
Topics: Alkynes; Catalysis; Cycloaddition Reaction; Gold; Isoxazoles; Models, Molecular; Pyrroles | 2015 |
Metal/organo relay catalysis in a one-pot synthesis of methyl 4-aminopyrrole-2-carboxylates from 5-methoxyisoxazoles and pyridinium ylides.
Topics: Carboxylic Acids; Catalysis; Cycloaddition Reaction; Isoxazoles; Metals; Models, Molecular; Molecular Structure; Pyridinium Compounds; Pyrroles | 2015 |
Catalytic enantioselective addition of isocyanoacetate to 3-methyl-4-nitro-5-styrylisoxazoles under phase transfer catalysis conditions.
Topics: Acetates; Catalysis; Cyclization; Isoxazoles; Methylation; Nitriles; Nitro Compounds; Pyrroles; Pyrrolidines; Stereoisomerism | 2015 |
Synthesis, antimycobacterial screening and ligand-based molecular docking studies on novel pyrrole derivatives bearing pyrazoline, isoxazole and phenyl thiourea moieties.
Topics: Anti-Bacterial Agents; Antitubercular Agents; Bacterial Proteins; Chemistry Techniques, Synthetic; Drug Evaluation, Preclinical; Enzyme Inhibitors; Escherichia coli; Humans; Isoxazoles; Ligands; Microbial Sensitivity Tests; Molecular Docking Simulation; Mycobacterium tuberculosis; Oxidoreductases; Pyrroles; Staphylococcus aureus; Thiourea | 2016 |
Lysophosphatidic acid activates Arf6 to promote the mesenchymal malignancy of renal cancer.
Topics: ADP-Ribosylation Factor 6; ADP-Ribosylation Factors; Adult; Aged; Aged, 80 and over; Amides; Animals; Antineoplastic Agents; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm; Enzyme Inhibitors; Epithelial-Mesenchymal Transition; Female; GTP-Binding Protein alpha Subunits, G12-G13; Guanine Nucleotide Exchange Factors; HEK293 Cells; Humans; Immunohistochemistry; Indoles; Isoxazoles; Kidney Neoplasms; Lysophospholipids; Male; Mice, Nude; Middle Aged; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Transplantation; Nerve Tissue Proteins; Propionates; Pyridines; Pyrroles; Receptors, Lysophosphatidic Acid; Signal Transduction; Sirolimus; Sunitinib; Triazoles | 2016 |
Design, synthesis and cytotoxic activities of scopoletin-isoxazole and scopoletin-pyrazole hybrids.
Topics: Antineoplastic Agents; Cell Line, Tumor; Humans; Indoles; Isoxazoles; Pyrazoles; Pyrroles; Scopoletin; Sunitinib | 2017 |
[3+2] Cycloaddition of Tosylmethyl Isocyanide with Styrylisoxazoles: Facile Access to Polysubstituted 3-(Isoxazol-5-yl)pyrroles.
Topics: Cyanides; Cycloaddition Reaction; Isoxazoles; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Structure; Pyrroles; Structure-Activity Relationship | 2017 |
Herpes Zoster and Tofacitinib: Clinical Outcomes and the Risk of Concomitant Therapy.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Chloroquine; Clinical Trials as Topic; Databases, Factual; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Glucocorticoids; Herpes Zoster; Humans; Incidence; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Multivariate Analysis; Piperidines; Proportional Hazards Models; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Risk Factors | 2017 |
BRD4 Profiling Identifies Critical Chronic Lymphocytic Leukemia Oncogenic Circuits and Reveals Sensitivity to PLX51107, a Novel Structurally Distinct BET Inhibitor.
Topics: Animals; Antineoplastic Agents; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Gene Expression Profiling; Gene Expression Regulation, Leukemic; Humans; Isoxazoles; Leukemia, Lymphocytic, Chronic, B-Cell; Mice; Mice, SCID; Nuclear Proteins; Pyridines; Pyrroles; Signal Transduction; Transcription Factors; Xenograft Model Antitumor Assays | 2018 |
Sea Urchin Embryo Model As a Reliable in Vivo Phenotypic Screen to Characterize Selective Antimitotic Molecules. Comparative evaluation of Combretapyrazoles, -isoxazoles, -1,2,3-triazoles, and -pyrroles as Tubulin-Binding Agents.
Topics: Animals; Antimitotic Agents; Cell Line, Tumor; Drug Screening Assays, Antitumor; Embryo, Nonmammalian; Humans; Isoxazoles; Pyrazoles; Pyrroles; Sea Urchins; Structure-Activity Relationship; Triazoles; Tubulin; Tubulin Modulators | 2018 |
T5224, RSPO2 and AZD5363 are novel drugs against functional pituitary adenoma.
Topics: Antineoplastic Agents; Benzophenones; Cell Line; Gene Expression Regulation; Gene Regulatory Networks; Humans; Isoxazoles; Oligonucleotide Array Sequence Analysis; Pituitary Gland; Pituitary Neoplasms; Pyrimidines; Pyrroles | 2019 |
Alpha 7 nicotinic receptor agonist and positive allosteric modulators improved social and molecular deficits of MK-801 model of schizophrenia in rats.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Avoidance Learning; Clozapine; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Disease Models, Animal; Dizocilpine Maleate; Glycogen Synthase Kinase 3 beta; Isoxazoles; Male; Phenylurea Compounds; Prefrontal Cortex; Proto-Oncogene Proteins c-akt; Pyridazines; Pyrroles; Rats; Rats, Wistar; Schizophrenia; Signal Transduction; Social Interaction; Treatment Outcome | 2020 |
α7 nicotinic receptor agonist and positive allosteric modulators differently improved schizophrenia-like cognitive deficits in male rats.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Antipsychotic Agents; Behavior, Animal; Cognitive Dysfunction; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hippocampus; Isoxazoles; Male; Nicotinic Agonists; Phenylurea Compounds; Pyridazines; Pyrroles; Rats; Rats, Wistar; Recognition, Psychology; Schizophrenia | 2021 |
An Isoxazole Strategy for Molybdenum-Mediated Synthesis of 5-Mono- and 4,5-Disubstituted 1
Topics: Isoxazoles; Molybdenum; Pyrroles; Quinoxalines | 2022 |
DFT Rationalization of Gold(I)-Catalyzed Couplings between Alkynyl Thioether and Nitrenoid Derivatives: Mechanism, Selectivity Patterns, and Effects of Substituents.
Topics: Catalysis; Gold; Isoxazoles; Pyrroles; Rationalization; Sulfides | 2022 |