Page last updated: 2024-08-18

pyrroles and indomethacin

pyrroles has been researched along with indomethacin in 99 studies

Research

Studies (99)

Timeframe	Studies, this research(%)	All Research%
pre-1990	45 (45.45)	18.7374
1990's	28 (28.28)	18.2507
2000's	17 (17.17)	29.6817
2010's	7 (7.07)	24.3611
2020's	2 (2.02)	2.80

Authors

Authors	Studies
Boyle, E; Freeman, PC; Goudie, AC; Mangan, FR; Thomson, M	1
Bertelli, A; Schinetti, ML	1
Perrotta, P; Silvestri, N	1
Panzone, G; Schiatti, P; Selva, D; Tarzia, G	1
Gussin, RZ; Hook, JB; Noordewier, B; Stygles, VG	1
Bailie, MD; Hook, JB; Noordewier, B	1
Aylward, M; Holly, F; Maddock, J; Parker, RJ; Thomas, SR	1
Remans, J	2
Vetter, G	1
Viara, M	1
Anciaux, H; Appelboom, T; Biltris, R; Chantraine, A; Coutellier, P; Danaux, R; Dessers, E; Dumont, M; Faure, J; François, P; Gilles, V; Moens, C; Postelmans, J; Robyns, R; Siquet, L; Van Heuken, Y; Van Rossum, P; Vandeputte, L; Verheugen, P	1
Commandre, F; Viani, JL	1
Arramon, JY; Laborie, G	1
Ku, EC; Wasvary, JM	1
Maibach, E	1
Salata, JJ; Taylor, RJ	1
Gross, D; Lobsiger, M; Rau, R	1
Bhattacherjee, P; Eakins, KE	2
Bhattacherjee, P; Hammond, BR	1
Franchimont, P; Frippiat, C	1
Biltris, R; Delmeiren, H; Desproges-Gotteron, R; Diverse, P; Gerard, R; Golstein, M; Le Guen, A; Vetter, G; Viara, M	1
Furukawa, K; Higo, N; Noda, K; Otagiri, M; Tsuji, M; Yano, T	1
Calixto, JB; Guimarães, CL; Rae, GA	1
Shikada, K; Tanaka, S; Yamamoto, A	1
Albus, U; Linz, W; Schölkens, BA	1
Chen, X; Pi, XJ	1
Abrahamsson, T; Carlsson, L	1
Carson, J; Fisher, MC; Persico, FJ; Pritchard, JF; Wong, S; Yorgey, K	1
Auzzi, G; Bruni, F; Costanzo, A; Longo, G; Matucci, M; Messori, A; Pecori Vettori, L; Perretti, F; Pirisino, R	1
Reilly, MA; Schayer, RW	1
Iizuka, Y; Tanaka, K	3
Beirne, JA; Bianchine, JR; Johnson, PC; Wortham, GF	1
Gardocki, JF; Pruss, TP; Wong, S	1
Campos, V; Evans, EF; Pollack, D; Proctor, JD; Velandia, J; Wasserman, AJ; Wingfield, WL	1
Iizuka, Y; Matsuda, K; Tanaka, K	1
Iizuka, Y; Kobayashi, K; Tanaka, K	1
Carson, JR; McKinstry, DN; Wong, S	1
Calin, A	1
Nakamura, H; Shimizu, M; Yokoyama, Y	1
Davies, J; Dixon, AS; Steele, CE	1
Shephard, NW; Steele, CE	1
Handrich, L	1
Hook, JB; Moore, GK; Noordewier, B; O'Neill, PJ; Yorgey, KA	1
Hashimoto, Y; Hoshina, K; Ishimoto, S; Jimba, M; Komoriya, K; Kurozumi, S; Naruchi, T; Ohtsu, A; Wakabayashi, T	1
Obata, Y; Oda, M; Yamamoto, N; Yokota, K	2
Iitaka, M; Ishii, J; Kitahama, S	1
Morita, I; Murota, S; Nakahama, K	1
Oda, M; Yamashita, A; Yokota, K	1
Högestätt, ED; Waldeck, K; Zygmunt, PM	1
Mellemkjaer, S; Nielsen-Kudsk, JE	1
Grundemar, L; Högestätt, ED; Zygmunt, PM	1
Algate, DR; Atterson, PR; Augustin, J; Elsässer, R; Laufer, S; Munt, PL; Tries, S	1
Albrecht, W; Algate, DR; Atterson, PR; Augustin, J; Elsässer, R; Guserle, R; Laufer, S; Munt, PL; Tries, S	1
Fukuda, K; Higo, N; Noda, K; Otagiri, M; Tsuji, M; Yano, T	1
Aloamaka, CP; Ebeigbe, AB; Ighoroje, AD; Oguogho, A	1
Liu, SY; Lu, X; Man, RY	1
Mombouli, JV; Nakashima, M; Taylor, AA; Vanhoutte, PM	1
McGrath, JC; Smith, GC	1
Abe, I; Fujii, K; Fujishima, M; Kobayashi, K; Ohmori, S; Ohya, Y; Takata, Y; Tominaga, M	1
DiMartino, M; Nambi, P; Patil, A; Wolff, C	1
Oda, M; Yamamoto, N; Yamashita, A; Yokota, K	1
Shikada, K; Tanaka, S	1
Davis, SC; Edwards, G; Högestätt, ED; Weston, AH; Zygmunt, PM	1
Fulton, D; Kaminski, P; McGiff, JC; Quilley, J; Wolin, MS	1
Flavahan, NA; Liu, Q	1
Akar, F; Aşlamaci, S; Kanzik, I; Köksoy, C; Tufan, H; Uydeş-Dogan, BS	1
Horibe, M; Murray, PA; Seki, S	1
Claus, R; Deigner, HP; Fyrnys, B; Wolf, G	1
Miyata, K; Yamano, M; Yasuda, S; Yuki, H	1
Belogi, L; Mezzadri, CM; Tubaro, E	2
Dannhardt, G; Fiebich, B; Kiefer, W; Krämer, G; Maehrlein, S; Nowe, U	1
Cheon, HG; Lee, DH; Lee, SS; Lim, H	1
Belogi, L; Bettelli, E; Mezzadri, CM; Tubaro, E	1
Okada, S; Shimizu, T; Yokotani, K	1
Ay, I; Tuncer, M	1
Bijev, A; Bocheva, A; Lessigiarska, I; Nankov, A; Pajeva, I	1
Kulkarni, SK; Patil, CS; Singh, VP	2
Harada, N; Isobe, H; Okajima, K; Uchiba, M	1
Alexandrova, A; Kesiova, M; Kirkova, M; Konstantinova, S; Petrov, L; Todorov, S; Tsvetanova, E	1
Asano, M; Harada, N; Mishima, A; Nakayama, T; Nomura, N; Okajima, K; Saito, T	1
Gardiner, P; Paine, SW; Parker, AJ; Riley, RJ; Webborn, PJ	1
Hershman, JM; Moatamed, F; Naeim, F; Sugawara, M; Tomoda, C	1
Kathirvel, K; Kuntamallappanavar, G; Leo, MD; Mishra, SK; Subramani, J; Uttam Singh, T	1
Buerke, M; Chen, L; Frister, A; Hofmann, B; Lautenschläger, M; Loppnow, H; Luther, T; Müller-Werdan, U; Rose-John, S; Schlitt, A; Silber, RE; Song, N; Werdan, K; Zhang, L	1
Cummons, T; Harrison, JE; Hummel, M; Kennedy, JD; Lu, P; Mark, L; Whiteside, GT	1
Agas, D; Di Magno, M; Loreto, MA; Migliorini, A; Sabbieti, MG; Serra Moreno, J	1
Hsieh, PC; Hung, SC; Lin, SP; Wang, YL	1
Chandrasekaran, G; Kumar, D; Kumar, T; Mahobiya, A; Parida, S; Rungsung, S; Singh, TU	1
Mori-Kawabe, M; Tsushima, H	1
Fujiwara, Y; Hattori, M; Higashimori, A; Hosomi, S; Kamata, N; Kosaka, S; Matsumoto, Y; Nadatani, Y; Nagami, Y; Nakata, A; Otani, K; Suda, W; Taira, K; Tanaka, F; Tanigawa, T; Watanabe, T; Yamagami, H	1
Aman, W; Dehpour, AR; Khan, MI; Mehrzadi, S; Nikoui, V; Ostadhadi, S	1
Cheng, X; Han, T; Jin, R; Li, J; Li, K	1

Reviews

1 review(s) available for pyrroles and indomethacin

Article	Year
Clinical use of tolmetin sodium in patients with ankylosing spondylitis: a review. Journal of clinical pharmacology, 1983, Volume: 23, Issue:7 Topics: Clinical Trials as Topic; Double-Blind Method; Humans; Ibuprofen; Indomethacin; Pyrroles; Spondylitis, Ankylosing; Tolmetin	1983

Trials

18 trial(s) available for pyrroles and indomethacin

Article	Year
[Evaluation of the therapeutic activity of a new nonsteroid antiphlogistic drug, Tolectin in rheumatoid arthritis]. Il Farmaco; edizione pratica, 1977, Volume: 31, Issue:7 Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Evaluation; Humans; Indomethacin; Pyrroles; Tolmetin	1977
Evaluation of tolmetin in the treatment of arthritis: open and controlled double-blind studies. Current medical research and opinion, 1976, Volume: 4, Issue:2 Topics: Adult; Arthritis, Rheumatoid; Chronic Disease; Clinical Trials as Topic; Drug Evaluation; Female; Humans; Indomethacin; Male; Middle Aged; Pyrroles; Tolmetin	1976
[Clinical study with 1-parachlorophenyl-2,5-dimethyl-3-pyrrolacetic acid "clopirac" (author's transl)]. Journal belge de rhumatologie et de medecine physique = Belgisch tijdschrift voor reumatologie en fysische geneeskunde, 1975, Volume: 30 Spec no Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Humans; Indomethacin; Pyrroles	1975
A double-blind comparison of clopirac and indomethacin in the treatment of rheumatoid arthritis. Journal belge de rhumatologie et de medecine physique = Belgisch tijdschrift voor reumatologie en fysische geneeskunde, 1975, Volume: 30 Spec no Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Humans; Indomethacin; Pyrroles	1975
[Double-blind study of clopirac and indomethacin in rheumatoid arthritis (author's transl)]. Journal belge de rhumatologie et de medecine physique = Belgisch tijdschrift voor reumatologie en fysische geneeskunde, 1975, Volume: 30 Spec no Topics: Adult; Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Female; Humans; Indomethacin; Male; Middle Aged; Pyrroles	1975
[Double-blind study comparing effectiveness of clopirac and indomethacine in osteoarthritis of the hip and the knee (author's transl)]. Journal belge de rhumatologie et de medecine physique = Belgisch tijdschrift voor reumatologie en fysische geneeskunde, 1975, Volume: 30 Spec no Topics: Clinical Trials as Topic; Hip Joint; Humans; Indomethacin; Joint Diseases; Knee Joint; Osteoarthritis; Pyrroles	1975
[Study of a new anti-inflammatory agent in rheumatoid arthritis (author's transl)]. Journal belge de rhumatologie et de medecine physique = Belgisch tijdschrift voor reumatologie en fysische geneeskunde, 1975, Volume: 30 Spec no Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Humans; Indomethacin; Pyrroles	1975
[Double-blind cross-over clinical study comparing clopirac with indomethacin in rheumatoid arthritis (author's transl)]. Journal belge de rhumatologie et de medecine physique = Belgisch tijdschrift voor reumatologie en fysische geneeskunde, 1975, Volume: 30 Spec no Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Humans; Indomethacin; Pyrroles	1975
European experiences with tolmetin in the treatment of rheumatic diseases. Current therapeutic research, clinical and experimental, 1976, Volume: 19, Issue:3 Topics: Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Female; Humans; Indomethacin; Male; Middle Aged; Osteoarthritis; Oxyphenbutazone; Placebos; Pyrroles; Rheumatic Diseases; Tolmetin; Wounds and Injuries	1976
[Treatment of severe osteoarthrosis of the knee and the hip with tolmentin. (A double-blind comparison with Indomethacin) (author's transl)]. Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1977, Feb-01, Volume: 66, Issue:5 Topics: Bone Diseases; Drug Evaluation; Hip; Humans; Indomethacin; Joint Diseases; Knee; Pyrroles; Tolmetin	1977
[Double-blind study of indomethacin and CP 172 AP (clopirac) in lombarthrosis (author's transl)]. Journal belge de rhumatologie et de medecine physique = Belgisch tijdschrift voor reumatologie en fysische geneeskunde, 1975, Volume: 30 Spec no Topics: Arthritis; Humans; Indomethacin; Lumbosacral Region; Pyrroles	1975
[Study in double-blind comparing clopirac to indomethacine in rheumatoid arthritis (author's transl)]. Journal belge de rhumatologie et de medecine physique = Belgisch tijdschrift voor reumatologie en fysische geneeskunde, 1975, Volume: 30 Spec no Topics: Arthritis, Rheumatoid; Humans; Indomethacin; Pyrroles	1975
Tolerance to pirprofen and preliminary efficacy trial in rheumatoid arthritis. Clinical pharmacology and therapeutics, 1974, Volume: 16, Issue:1 Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Evaluation; Female; Humans; Indomethacin; Joints; Male; Middle Aged; Phenylpropionates; Placebos; Prisoners; Pyrroles; Time Factors	1974
Clinical use of tolmetin sodium in patients with ankylosing spondylitis: a review. Journal of clinical pharmacology, 1983, Volume: 23, Issue:7 Topics: Clinical Trials as Topic; Double-Blind Method; Humans; Ibuprofen; Indomethacin; Pyrroles; Spondylitis, Ankylosing; Tolmetin	1983
Tolmetin sodium and indomethacin in the treatment of osteoarthrosis of the hip: a double-blind crossover study. Current medical research and opinion, 1980, Volume: 7, Issue:2 Topics: Activities of Daily Living; Aged; Clinical Trials as Topic; Double-Blind Method; Hip; Humans; Indomethacin; Middle Aged; Osteoarthritis; Pain; Pyrroles; Tolmetin	1980
Comparison of tolmetin sodium with indomethacin in osteoarthritis. The Practitioner, 1981, Volume: 225, Issue:1361 Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Hip Joint; Humans; Indomethacin; Knee Joint; Osteoarthritis; Pyrroles; Tolmetin	1981
[Comparison of the therapeutic efficacy and tolerability of acemetacin and tolmetin (author's transl)]. Arzneimittel-Forschung, 1980, Volume: 30, Issue:8A Topics: Adult; Aged; Anti-Inflammatory Agents; Double-Blind Method; Female; Humans; In Vitro Techniques; Indoleacetic Acids; Indomethacin; Inflammation; Male; Middle Aged; Pain; Pyrroles; Tolmetin	1980
Statins potently reduce the cytokine-mediated IL-6 release in SMC/MNC cocultures. Journal of cellular and molecular medicine, 2011, Volume: 15, Issue:4 Topics: Aspirin; Atorvastatin; Cell Separation; Coculture Techniques; Dose-Response Relationship, Drug; Drug Synergism; Heptanoic Acids; HMGB1 Protein; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indomethacin; Interleukin-1; Interleukin-6; Leukocytes, Mononuclear; Lipopolysaccharides; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphorylation; Pyrroles; Recombinant Proteins; Simvastatin; STAT3 Transcription Factor; Time Factors; Tumor Necrosis Factor-alpha	2011

Other Studies

81 other study(ies) available for pyrroles and indomethacin

Article	Year
The role of copper in preventing gastrointestinal damage by acidic anti-inflammatory drugs. The Journal of pharmacy and pharmacology, 1976, Volume: 28, Issue:12 Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chelating Agents; Copper; Edema; Female; In Vitro Techniques; Indomethacin; Ketoprofen; Male; Naproxen; Niflumic Acid; Peptic Ulcer; Prostaglandins E; Pyrroles; Rats	1976
Activity of tolmetin on levels of cyclic nucleotides in experimental pleurisy. Arzneimittel-Forschung, 1979, Volume: 29, Issue:5 Topics: Acetates; Animals; Cyclic AMP; Cyclic GMP; Indomethacin; Male; Pleurisy; Pyrroles; Rats; Tolmetin	1979
Synthesis and anti-inflammatory properties of some pyrrolo(1H,3H)[3,4-d]pyrimidin-2-ones and pyrrolo(1H,6H)[3,4-d]pyrimidin-2-ones. Il Farmaco; edizione scientifica, 1979, Volume: 34, Issue:4 Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Aspirin; Edema; Female; Indomethacin; Male; Mice; Pyrimidinones; Pyrroles; Rats	1979
Effect of tolmetin on renal function and prostaglandin metabolism. The Journal of pharmacology and experimental therapeutics, 1978, Volume: 204, Issue:2 Topics: Animals; Dogs; In Vitro Techniques; Indomethacin; Kidney; Male; Oxygen Consumption; Prostaglandins E; Pyrroles; Rats; Regional Blood Flow; Tolmetin	1978
Effects of indomethacin and tolmetin on furosemide-induced changes in renin release. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1978, Volume: 159, Issue:2 Topics: Animals; Calcium; Dogs; Furosemide; Indomethacin; Kidney; Male; Potassium; Pyrroles; Renin; Sodium; Tolmetin	1978
Inhibition of prostaglandin synthase by pirprofen. Studies with sheep seminal vesicle enzyme. Biochimica et biophysica acta, 1975, Apr-19, Volume: 384, Issue:2 Topics: Animals; Antimetabolites; Arachidonic Acids; Cyclooxygenase Inhibitors; Indomethacin; Kinetics; Male; Microsomes; Mixed Function Oxygenases; Phenylpropionates; Pyrroles; Seminal Vesicles; Sheep; Stereoisomerism; Structure-Activity Relationship; Time Factors	1975
Inhibition of prostaglandin synthetase by tolmetin (Tolectin, McN-2559), a new non-steroidal anti-inflammatory agent. Biochemical pharmacology, 1976, Nov-15, Volume: 25, Issue:22 Topics: Animals; Aspirin; Cattle; Cyclooxygenase Inhibitors; Indomethacin; Kinetics; Male; Microsomes; Mixed Function Oxygenases; Prostaglandins E; Pyrroles; Seminal Vesicles; Structure-Activity Relationship; Tolmetin	1976
Inhibition of the ocular effects of sodium arachidonate by anti-inflammatory compounds. Prostaglandins, 1975, Volume: 9, Issue:2 Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Aqueous Humor; Arachidonic Acids; Conjunctiva; Dexamethasone; Eye; Eye Proteins; Indoles; Indomethacin; Intraocular Pressure; Phenylpropionates; Prostaglandins; Pupil; Pyrroles; Rabbits; Stimulation, Chemical	1975
Inhibition of increased permeability of the blood-aqueous barrier by non-steroidal anti-inflammatory compounds as demonstrated by fluorescein angiography. Experimental eye research, 1975, Volume: 21, Issue:6 Topics: Animals; Anisoles; Anti-Inflammatory Agents; Aqueous Humor; Capillary Permeability; Eicosanoic Acids; Eye; Fluorescein Angiography; Indoles; Indomethacin; Phenylpropionates; Pyrroles; Rabbits	1975
[Review of the clinical studies in rheumatoid arthritis with several non steroid anti-inflammatory agents (author's transl)]. Journal belge de rhumatologie et de medecine physique = Belgisch tijdschrift voor reumatologie en fysische geneeskunde, 1975, Volume: 30 Spec no Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Drug Evaluation; Humans; Indomethacin; Ketoprofen; Phenylbutazone; Pyrroles	1975
Evaluation of a new penetration enhancer 1-[2-(decylthio)ethyl]azacyclopentan-2-one (HPE-101). Journal of pharmacobio-dynamics, 1992, Volume: 15, Issue:9 Topics: Animals; Azepines; Drug Carriers; Female; Indomethacin; Mice; Mice, Hairless; Pyrroles; Skin Absorption; Solvents	1992
Potent constrictor actions of endothelin-1, endothelin-2, and endothelin-3 in rat isolated portal vein. Hypertension (Dallas, Tex. : 1979), 1992, Volume: 19, Issue:2 Suppl Topics: Alkaloids; Animals; Benzopyrans; Calcium; Cromakalim; Endothelins; Glyburide; Indomethacin; Male; Mesenteric Veins; Nicardipine; Phorbols; Portal Vein; Protein Kinase C; Pyrroles; Rats; Rats, Inbred Strains; Staurosporine; Vasoconstriction; Vasodilator Agents	1992
NIP-121 and cromakalim, potassium channel openers, preferentially suppress prostanoid-induced contraction of the guinea-pig isolated trachea. European journal of pharmacology, 1991, Dec-10, Volume: 209, Issue:1-2 Topics: Animals; Arachidonic Acid; Benzopyrans; Cromakalim; Dinoprost; Glyburide; Guinea Pigs; Indomethacin; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Oxadiazoles; Piperidines; Potassium Channels; Prostaglandin D2; Prostaglandin Endoperoxides, Synthetic; Prostaglandins; Pyrroles; Sulfonamides; Trachea	1991
Effects of endothelin on isolated ischaemic rat hearts during ramiprilat, bradykinin and indomethacin perfusion. Journal of hypertension. Supplement : official journal of the International Society of Hypertension, 1989, Volume: 7, Issue:6 Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin; Drug Evaluation, Preclinical; Drug Interactions; Drug Therapy, Combination; Endothelins; Endothelium, Vascular; Female; In Vitro Techniques; Indomethacin; Male; Myocardial Reperfusion; Myocardial Reperfusion Injury; Peptides; Pyrroles; Ramipril; Rats; Rats, Inbred Strains; Vasoconstrictor Agents	1989
Captopril and ramiprilat protect against free radical injury in isolated working rat hearts. Journal of molecular and cellular cardiology, 1989, Volume: 21, Issue:12 Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Dimethyl Sulfoxide; Disulfides; Dose-Response Relationship, Drug; Electrocardiography; Female; Free Radicals; Heart; Indomethacin; Myocardium; Pyrroles; Ramipril; Rats; Rats, Inbred Strains; Sulfhydryl Compounds; Time Factors	1989
Ramiprilat attenuates the local release of noradrenaline in the ischemic myocardium. European journal of pharmacology, 1989, Jul-18, Volume: 166, Issue:2 Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin; Coronary Disease; Creatine Kinase; Heart; In Vitro Techniques; Indomethacin; Male; Myocardium; Norepinephrine; Pyrroles; Ramipril; Rats; Rats, Inbred Strains; Saralasin	1989
Effect of tolmetin glycine amide (McN-4366), a prodrug of tolmetin sodium, on adjuvant arthritis in the rat. The Journal of pharmacology and experimental therapeutics, 1988, Volume: 247, Issue:3 Topics: Animals; Arthritis; Arthritis, Experimental; Bone and Bones; Digestive System; Female; Indomethacin; Prodrugs; Pyrroles; Rats; Tolmetin	1988
Pharmacological activity of some pyrrolo and pyrazolo pyrimidine derivatives. Il Farmaco; edizione scientifica, 1987, Volume: 42, Issue:11 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Edema; Humans; In Vitro Techniques; Indomethacin; Lethal Dose 50; Male; Platelet Aggregation Inhibitors; Pyrazoles; Pyrimidines; Pyrroles; Rats; Restraint, Physical; Stomach Ulcer	1987
Suppression of inflammation and histidine decarboxylase by protein synthesis inhibitors. The American journal of physiology, 1968, Volume: 215, Issue:2 Topics: Animals; Carbon Isotopes; Carboxy-Lyases; Carrageenan; Cycloheximide; Dactinomycin; Endotoxins; Female; Hydrocortisone; Indomethacin; Inflammation; Mice; Polymyxins; Protein Biosynthesis; Proteins; Puromycin; Pyrroles; Rats; Turpentine	1968
A comparison of the inhibitory activity of compounds on ocular prostaglandin biosynthesis. Investigative ophthalmology, 1974, Volume: 13, Issue:12 Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Arachidonic Acids; Aspirin; Cell Fractionation; Ciliary Body; Conjunctiva; Dexamethasone; Eye; Female; In Vitro Techniques; Indoles; Indomethacin; Iris; Male; Microsomes; Mixed Function Oxygenases; Multienzyme Complexes; Oxyphenbutazone; Phenylbutazone; Phenylpropionates; Propionates; Prostaglandins; Pyrroles; Rabbits; Tissue Extracts	1974
][A new method for screening of analgesics applied to heat induced inflammatory pain]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1974, Volume: 70, Issue:5 Topics: Aminopyrine; Analgesics; Animals; Aspirin; Burns; Drug Evaluation, Preclinical; Flufenamic Acid; Habituation, Psychophysiologic; Hot Temperature; Ibuprofen; Indomethacin; Inflammation; Mefenamic Acid; Phenylbutazone; Pyrroles; Rats	1974
Gastrointestinal blood loss caused by tolmetin, aspirin, and indomethacin. Clinical pharmacology and therapeutics, 1974, Volume: 16, Issue:5 Part 1 Topics: Adult; Anti-Inflammatory Agents; Aspirin; Benzoates; Chromium Radioisotopes; Diet; Female; Gastrointestinal Hemorrhage; Humans; Indomethacin; Male; Melena; Pyrroles; Time Factors	1974
Pharmacologic evaluation of tolectin (tolmetin, mcn-2559) and mcn-2891, two anti-inflammatory agents. The Journal of pharmacology and experimental therapeutics, 1973, Volume: 185, Issue:1 Topics: Acetylcholine; Analysis of Variance; Animals; Anti-Inflammatory Agents; Arthritis; Arthritis, Rheumatoid; Behavior, Animal; Benzoates; Blood Pressure; Carrageenan; Dose-Response Relationship, Drug; Edema; Female; Freund's Adjuvant; Heart; Indomethacin; Male; Osteoarthritis; Phenylbutazone; Pyrroles; Quinones; Rats; Saccharomyces cerevisiae; Toluene	1973
[Anti-inflammatory effect of bimetopyrol. II. Suppressive effect on adjuvant arthritis in rats]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1972, Volume: 92, Issue:1 Topics: Animals; Anti-Inflammatory Agents; Arthritis; Body Weight; Female; Flufenamic Acid; Glucocorticoids; Indomethacin; Organ Size; Phenylbutazone; Pyrroles; Rats; Rats, Inbred Strains	1972
[Anti-inflammatory effect of bimetopyrol. I. Suppressive effect on acute inflammation]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1972, Volume: 92, Issue:1 Topics: Animals; Anti-Inflammatory Agents; Aspirin; Cyproheptadine; Edema; Erythema; Fever; Flufenamic Acid; Glucocorticoids; Granuloma; Indomethacin; Lethal Dose 50; Male; Mice; Phenylbutazone; Pyrroles; Rats; Rats, Inbred Strains; Triamcinolone Acetonide	1972
[Anti-inflammatory effect of bimetopyrol. 3. Possible active substance and site of action]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1972, Volume: 92, Issue:3 Topics: Administration, Oral; Adrenalectomy; Animals; Anisoles; Anti-Inflammatory Agents; Binding Sites; Edema; Indomethacin; Injections, Subcutaneous; Male; Phenylbutazone; Pyrroles; Rats; Rats, Inbred Strains	1972
[Anti-inflammatory effect of bimetopyrol. IV. Stabilizing effect on rat liver lysosomes]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1972, Volume: 92, Issue:3 Topics: Acid Phosphatase; Analgesics; Animals; Anisoles; Anti-Inflammatory Agents; Ethanol; Flufenamic Acid; Hydrocortisone; Hydrogen-Ion Concentration; Indoles; Indomethacin; Liver; Lysosomes; Male; Phenylbutazone; Pyrroles; Rats; Rats, Inbred Strains	1972
5-Benzoyl-1-methylpyrrole-2-acetic acids as antiinflammatory agents. Journal of medicinal chemistry, 1971, Volume: 14, Issue:17 Topics: Acetates; Animals; Anti-Inflammatory Agents; Benzoates; Carrageenan; Edema; Granuloma; Indomethacin; Kaolin; Male; Phenylbutazone; Pyrroles; Structure-Activity Relationship	1971
Gastrointestinal ulcerogenic activity of tolmetin sodium in rats in comparison with those of indomethacin and aspirin. Chemical & pharmaceutical bulletin, 1984, Volume: 32, Issue:11 Topics: Animals; Aspirin; Indomethacin; Male; Peptic Ulcer; Pyrroles; Rats; Rats, Inbred Strains; Tolmetin	1984
Effects of zomepirac and indomethacin on renal blood flow and electrolyte excretion in anesthetized monkeys. Life sciences, 1981, Sep-28, Volume: 29, Issue:13 Topics: Anesthesia; Animals; Electrolytes; Glomerular Filtration Rate; Indomethacin; Macaca mulatta; Male; Pyrroles; Renal Circulation; Tolmetin	1981
Inhibition of platelet aggregation by novel benzoylpyrrole derivatives. Advances in prostaglandin and thromboxane research, 1980, Volume: 6 Topics: Adenosine Diphosphate; Animals; Arachidonic Acids; Biological Assay; Blood Platelets; Cattle; Collagen; Epinephrine; Humans; Indomethacin; Male; Platelet Aggregation; Prostaglandin Endoperoxides; Pyrroles; Rabbits; Rats	1980
Inhibitory effect of KBT-3022, a new anti-platelet agent, on infiltration of polymorphonuclear leukocytes induced by leukotriene B4 or formyl-methionyl-leucyl-phenylalanine in mice. Japanese journal of pharmacology, 1995, Volume: 68, Issue:3 Topics: Animals; Dexamethasone; Dose-Response Relationship, Drug; Indomethacin; Leukocytes; Leukotriene B4; Mice; Mice, Inbred Strains; N-Formylmethionine Leucyl-Phenylalanine; Platelet Aggregation Inhibitors; Pyrroles; Thiazoles	1995
Involvement of protein kinase A and C in the production of interleukin-1 alpha-induced prostaglandin E2 from mouse osteoblast-like cell line, MC3T3-E1. Biochimica et biophysica acta, 1994, Mar-10, Volume: 1221, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; 3T3 Cells; 8-Bromo Cyclic Adenosine Monophosphate; Alkaloids; Animals; Carbazoles; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Dinoprostone; Humans; Indoles; Indomethacin; Interleukin-1; Isoquinolines; Kinetics; Mice; Osteoblasts; Piperazines; Protein Kinase C; Pyrroles; Recombinant Proteins; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate	1994
Effects of endogenously produced arachidonic acid metabolites on rat mesangial cell proliferation. Prostaglandins, leukotrienes, and essential fatty acids, 1994, Volume: 51, Issue:3 Topics: 1-Methyl-3-isobutylxanthine; 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Animals; Arachidonic Acid; Benzeneacetamides; Bucladesine; Carbazoles; Cell Division; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dinoprost; Dinoprostone; DNA Replication; Flavanones; Flavonoids; Glomerular Mesangium; Hydroxamic Acids; Hydroxyeicosatetraenoic Acids; Indoles; Indomethacin; Lipoxygenase Inhibitors; Male; Platelet-Derived Growth Factor; Pyrroles; Rats; Rats, Sprague-Dawley; Umbelliferones	1994
Anti-thrombotic activity of KBT-3022 in experimental models of thrombosis. Japanese journal of pharmacology, 1995, Volume: 68, Issue:2 Topics: Animals; Arachidonic Acid; Aspirin; Cyclooxygenase Inhibitors; Extracorporeal Circulation; Guinea Pigs; In Vitro Techniques; Indomethacin; Male; Mice; Mice, Inbred Strains; Platelet Aggregation Inhibitors; Pyrroles; Rabbits; Silver Nitrate; Thiazoles; Thrombosis; Ticlopidine	1995
The endothelium mediates a nitric oxide-independent hyperpolarization and relaxation in the rat hepatic artery. Acta physiologica Scandinavica, 1994, Volume: 152, Issue:4 Topics: Acetylcholine; Animals; Arginine; Benzopyrans; Cell Polarity; Cromakalim; Endothelium, Vascular; Female; Hepatic Artery; Indomethacin; Membrane Potentials; Muscle Relaxation; Muscle, Smooth, Vascular; Nimodipine; Nitric Oxide; Nitroarginine; Phenylephrine; Prazosin; Pyrroles; Rats; Rats, Sprague-Dawley	1994
Glibenclamide inhibits hypoxic relaxation of isolated porcine coronary arteries under conditions of impaired glycolysis. European journal of pharmacology, 1994, Aug-03, Volume: 270, Issue:4 Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Triphosphate; Animals; Benzopyrans; Coronary Vessels; Cromakalim; Deoxyglucose; Endothelium, Vascular; Glyburide; Glycolysis; Hypoxia; In Vitro Techniques; Indomethacin; Isometric Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Swine; Theophylline; Thromboxane A2; Vasoconstrictor Agents; Vasodilator Agents	1994
Light-dependent effects of zinc protoporphyrin IX on endothelium-dependent relaxation resistant to N omega-nitro-L-arginine. Acta physiologica Scandinavica, 1994, Volume: 152, Issue:2 Topics: Acetylcholine; Animals; Arginine; Benzopyrans; Biliverdine; Carbon Monoxide; Cromakalim; Darkness; Endothelium, Vascular; Female; Heme Oxygenase (Decyclizing); Hepatic Artery; In Vitro Techniques; Indomethacin; Light; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitroarginine; Oxyhemoglobins; Phenylephrine; Potassium; Potassium Channels; Protoporphyrins; Pyrroles; Rats; Rats, Sprague-Dawley; Vasodilator Agents	1994
Gastrointestinal tolerance of [2,2-dimethyl-6-(4-chlorophenyl-7-phenyl- 2,3-dihydro-1H-pyrrolizine-5-yl]-acetic acid in the rat. Arzneimittel-Forschung, 1994, Volume: 44, Issue:12 Topics: Acetates; Animals; Gastric Mucosa; Indomethacin; Intestinal Mucosa; Lipoxygenase Inhibitors; Male; Peptic Ulcer; Peptic Ulcer Hemorrhage; Pyrroles; Rats; Rats, Wistar	1994
Acute and chronic anti-inflammatory properties of [2,2-dimethyl-6-(4- chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl]-acetic acid. Arzneimittel-Forschung, 1995, Volume: 45, Issue:1 Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Body Weight; Carrageenan; Cyclooxygenase Inhibitors; Edema; Female; Foot; Indomethacin; Male; Pyrroles; Rats; Rats, Wistar	1995
Further evaluation of a new penetration enhancer, HPE-101. The Journal of pharmacy and pharmacology, 1993, Volume: 45, Issue:9 Topics: Administration, Cutaneous; Animals; Drug Carriers; Estradiol; Female; Fluorouracil; Glycols; Indomethacin; Male; Mice; Mice, Hairless; Niacin; Pyrroles; Rats; Rats, Wistar; Skin Absorption; Triamcinolone Acetonide	1993
Differential effects of prostanoid synthesis inhibitors on cicletanine-induced relaxation of isolated human epigastric arteries. Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 1994, Volume: 4, Issue:3 Topics: Abdominal Muscles; Antihypertensive Agents; Arteries; Benzopyrans; Cromakalim; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Humans; In Vitro Techniques; Indomethacin; Meclofenamic Acid; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Pyridines; Pyrroles; Tranylcypromine	1994
Enhancement of endothelium dependent relaxation in the rat aortic ring by selenium supplement. Cardiovascular research, 1994, Volume: 28, Issue:3 Topics: Acetylcholine; Animals; Aorta; Arginine; Benzopyrans; Cromakalim; Culture Techniques; Endothelium, Vascular; Glutathione Peroxidase; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Nitroprusside; Pyrroles; Rats; Rats, Sprague-Dawley; Selenium; Vasoconstriction; Vasodilator Agents	1994
Endothelium-dependent hyperpolarization caused by bradykinin in human coronary arteries. The Journal of clinical investigation, 1993, Volume: 92, Issue:6 Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Arginine; Benzopyrans; Bradykinin; Calcimycin; Child; Coronary Vessels; Cromakalim; Dinoprost; Endothelium, Vascular; Glyburide; Humans; In Vitro Techniques; Indoles; Indomethacin; Infant; Male; Membrane Potentials; Middle Aged; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroarginine; Pyrroles; Vasodilator Agents	1993
Characterisation of the effect of oxygen tension on response of fetal rabbit ductus arteriosus to vasodilators. Cardiovascular research, 1993, Volume: 27, Issue:12 Topics: Adenosine; Animals; Atrial Natriuretic Factor; Benzopyrans; Colforsin; Cromakalim; Culture Techniques; Cyclooxygenase Inhibitors; Dinoprostone; Ductus Arteriosus; Epoprostenol; Flurbiprofen; Indomethacin; Nifedipine; Nitroprusside; Norepinephrine; Oxygen; Pyrroles; Rabbits; Vasodilator Agents	1993
Age-related changes in endothelium-dependent hyperpolarization in the rat mesenteric artery. The American journal of physiology, 1993, Volume: 265, Issue:2 Pt 2 Topics: Acetylcholine; Aging; Animals; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Electrophysiology; Endothelium, Vascular; Indomethacin; Male; Mesenteric Arteries; Norepinephrine; Pyrroles; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vasodilation	1993
Effects of a protein kinase C inhibitor (PKCI) on the development of adjuvant-induced arthritis (AA) in rats. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1995, Volume: 44 Suppl 2 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Experimental; Azepines; Enzyme Inhibitors; Indomethacin; Lymphocyte Activation; Male; Methotrexate; Protein Kinase C; Pyrroles; Rats; Rats, Inbred Lew	1995
Effect of KBT-3022, a new cyclooxygenase inhibitor, on experimental brain edema in vitro and in vivo. European journal of pharmacology, 1996, Feb-22, Volume: 297, Issue:3 Topics: Animals; Arachidonic Acid; Aspirin; Brain; Brain Edema; Brain Ischemia; Cyclooxygenase Inhibitors; Gerbillinae; Guinea Pigs; In Vitro Techniques; Indomethacin; Lipid Peroxidation; Male; Pyrroles; Thiazoles	1996
Effect of the K+ channel openers NIP-121 and cromakalim on melittin-induced relaxation of guinea-pig isolated trachea. Prostaglandins, 1996, Volume: 51, Issue:5 Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Benzopyrans; Cromakalim; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Activation; Epithelium; Guinea Pigs; Histamine; Indomethacin; Leukotriene D4; Male; Melitten; Muscle Relaxation; Muscle, Smooth; Oxadiazoles; Phospholipases A; Phospholipases A2; Piperidines; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Thromboxane A2; Trachea	1996
Effects of cytochrome P450 inhibitors on EDHF-mediated relaxation in the rat hepatic artery. British journal of pharmacology, 1996, Volume: 118, Issue:5 Topics: Acetylcholine; Animals; Benzopyrans; Biological Factors; Clotrimazole; Cromakalim; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fatty Acids, Unsaturated; Female; Hepatic Artery; Indomethacin; Membrane Potentials; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitroarginine; Potassium Channels; Proadifen; Pyrroles; Rats; Rats, Sprague-Dawley; Vasodilator Agents	1996
Inhibitory effects of the new anti-platelet agent KBT-3022 and its metabolite on rabbit neutrophil function in vitro. Japanese journal of pharmacology, 1996, Volume: 70, Issue:4 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Binding Sites; Calcium; Cell Adhesion; Cilostazol; Complement C3-C5 Convertases; Complement C5a; Cyclooxygenase Inhibitors; Indomethacin; Leukotriene B4; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Platelet Aggregation Inhibitors; Pyrroles; Rabbits; Structure-Activity Relationship; Superoxides; Tetradecanoylphorbol Acetate; Tetrazoles; Thiazoles; Ticlopidine	1996
Evidence against a cytochrome P450-derived reactive oxygen species as the mediator of the nitric oxide-independent vasodilator effect of bradykinin in the perfused heart of the rat. The Journal of pharmacology and experimental therapeutics, 1997, Volume: 280, Issue:2 Topics: Animals; Arachidonic Acid; Benzimidazoles; Benzopyrans; Bradykinin; Cromakalim; Cyclic N-Oxides; Cytochrome P-450 Enzyme System; Free Radical Scavengers; Heart; Hydrogen Peroxide; Imidazoles; In Vitro Techniques; Indomethacin; Kidney Cortex; Luminescent Measurements; Male; Microsomes; Nitric Oxide; Nitroarginine; Parasympatholytics; Perfusion; Pyrazines; Pyrroles; Rats; Rats, Wistar; Reactive Oxygen Species; Superoxides; Vasodilator Agents	1997
Hypoxic dilatation of porcine small coronary arteries: role of endothelium and KATP-channels. British journal of pharmacology, 1997, Volume: 120, Issue:4 Topics: Animals; Benzopyrans; Cell Hypoxia; Coronary Vessels; Cromakalim; Endothelium, Vascular; Glyburide; In Vitro Techniques; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Potassium Channels; Pyrroles; Swine; Vasodilation	1997
The comparison of the responsiveness of human isolated internal mammary and gastroepiploic arteries to levcromakalim: an alternative approach to the management of graft spasm. British journal of clinical pharmacology, 1997, Volume: 44, Issue:1 Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Arteries; Benzopyrans; Coronary Artery Bypass; Cromakalim; Endothelin-1; Female; Glyburide; Humans; In Vitro Techniques; Indomethacin; Male; Mammary Arteries; Middle Aged; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroarginine; Norepinephrine; Omentum; Potassium; Potassium Channel Blockers; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Stomach; Thromboxane A2; Vasoconstrictor Agents; Vasodilator Agents	1997
Halothane attenuates endothelium-dependent pulmonary vasorelaxant response to lemakalim, an adenosine triphosphate (ATP)-sensitive potassium channel agonist. Anesthesiology, 1997, Volume: 87, Issue:3 Topics: Adenosine Triphosphate; Anesthetics, Inhalation; Animals; Benzopyrans; Cromakalim; Dogs; Endothelium, Vascular; Glyburide; Halothane; Humans; Indomethacin; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Potassium Channels; Pulmonary Artery; Pyrroles; Vasodilation; Vasodilator Agents	1997
Oxidized low density lipoprotein stimulates protein kinase C (PKC) activity and expression of PKC-isotypes via prostaglandin-H-synthase in P388D1 cells. Advances in experimental medicine and biology, 1997, Volume: 407 Topics: Acetates; Animals; Cyclooxygenase Inhibitors; Cytosol; Enzyme Activation; Enzyme Induction; Indomethacin; Isoenzymes; Leukemia P388; Lipoproteins, LDL; Lipoxygenase Inhibitors; Macrophages; Masoprocol; Mice; Neoplasm Proteins; Nitrobenzenes; Oxidation-Reduction; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Protein Processing, Post-Translational; Pyrroles; Serum Albumin, Bovine; Sulfonamides	1997
Corticotropin-releasing hormone receptors mediate consensus interferon-alpha YM643-induced depression-like behavior in mice. The Journal of pharmacology and experimental therapeutics, 2000, Volume: 292, Issue:1 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; Behavior, Animal; Depression, Chemical; Dose-Response Relationship, Drug; Drug Interactions; Imipramine; Indomethacin; Interferon-alpha; Male; Mice; Motor Activity; Naloxone; Narcotic Antagonists; Pyrimidines; Pyrroles; Receptors, Corticotropin-Releasing Hormone; Time Factors	2000
The mechanism of action of amtolmetin guacyl, a new gastroprotective nonsteroidal anti-inflammatory drug. European journal of pharmacology, 2000, Jan-10, Volume: 387, Issue:2 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dinoprostone; Drug Stability; Gastric Acid; Gastric Mucosa; Glycine; Indomethacin; Male; Pyrroles; Rats; Rats, Wistar; Receptors, Calcitonin Gene-Related Peptide; Receptors, Drug	2000
The pyrrole moiety as a template for COX-1/COX-2 inhibitors. European journal of medicinal chemistry, 2000, Volume: 35, Issue:5 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Cattle; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Humans; Indomethacin; Isoenzymes; Leukocytes, Mononuclear; Membrane Proteins; Molecular Structure; Monocytes; Neutrophils; Prostaglandin-Endoperoxide Synthases; Pyrroles; Sulfones; Thiophenes	2000
Pharmacological properties of a newly synthesized H(+)/K(+) ATPase inhibitor, 1-(2-methyl-4-methoxyphenyl)-4-. European journal of pharmacology, 2001, Jan-05, Volume: 411, Issue:1-2 Topics: Animals; Anti-Ulcer Agents; Aspirin; Cysteamine; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethanol; Gastric Acid; Gastric Mucosa; H(+)-K(+)-Exchanging ATPase; Indomethacin; Omeprazole; Perfusion; Proton Pump Inhibitors; Pyrroles; Quinolines; Rats; Rats, Sprague-Dawley; Sodium Hydroxide; Stomach; Stomach Ulcer; Time Factors	2001
Anti-inflammatory and antiplatelet effects of amtolmetin guacyl, a new gastroprotective non-steroidal anti-inflammatory drug. Arzneimittel-Forschung, 2001, Volume: 51, Issue:9 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis; Body Weight; Bone Density; Carrageenan; Dose-Response Relationship, Drug; Exudates and Transudates; Glycine; In Vitro Techniques; Indomethacin; Male; Piroxicam; Platelet Aggregation; Platelet Aggregation Inhibitors; Pleurisy; Pyrroles; Rats; Thromboxane B2	2001
Impact on the bowel of amtolmetin guacyl, a new gastroprotective non-steroidal anti-inflammatory drug. European journal of pharmacology, 2003, Apr-25, Volume: 467, Issue:1-3 Topics: Acetic Acid; Aminosalicylic Acids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Colon; Dose-Response Relationship, Drug; Glycine; Guinea Pigs; Ileitis; Ileum; In Vitro Techniques; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Peroxidase; Pyrroles; Rats; Rats, Wistar; Sulfasalazine; Ulcer	2003
Extrahypothalamic corticotropin-releasing hormone mediates (-)-nicotine-induced elevation of plasma corticosterone in rats. European journal of pharmacology, 2003, Jul-25, Volume: 473, Issue:2-3 Topics: Animals; Corticosterone; Corticotropin-Releasing Hormone; Cyclooxygenase Inhibitors; Indomethacin; Male; Microdialysis; Nicotine; Norepinephrine; Paraventricular Hypothalamic Nucleus; Pyrimidines; Pyrroles; Rats; Rats, Wistar; Receptors, Corticotropin-Releasing Hormone; Time Factors	2003
Mechanism of CGRP-induced vasodilation in the rat isolated perfused kidney. Pharmacology, 2004, Volume: 71, Issue:4 Topics: Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Carbazoles; Cyclic AMP-Dependent Protein Kinases; Cyclooxygenase Inhibitors; Endothelium, Vascular; Guanylate Cyclase; In Vitro Techniques; Indoles; Indomethacin; Kidney; Nitroarginine; Octoxynol; Peptide Fragments; Potassium Channels; Pyrroles; Rats; Rats, Wistar; Vasodilation	2004
3D-QSAR and preliminary evaluation of anti-inflammatory activity of series of N-pyrrolylcarboxylic acids. Farmaco (Societa chimica italiana : 1989), 2005, Volume: 60, Issue:3 Topics: Animals; Anti-Inflammatory Agents; Binding Sites; Carrageenan; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Edema; Indomethacin; Prostaglandin-Endoperoxide Synthases; Pyrroles; Quantitative Structure-Activity Relationship; Rats; Structure-Activity Relationship	2005
Effect of licofelone against NSAIDs-induced gastrointestinal ulceration and inflammation. Indian journal of experimental biology, 2005, Volume: 43, Issue:3 Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Female; Humans; Indomethacin; Inflammation; Leukotriene B4; Lipid Peroxidation; Male; Mesentery; Mice; Neutrophils; Pyrroles; Rats; Stomach Ulcer; Time Factors	2005
Anti-inflammatory effect of licofelone against various inflammatory challenges. Fundamental & clinical pharmacology, 2006, Volume: 20, Issue:1 Topics: Acetates; Animals; Anti-Inflammatory Agents; Carrageenan; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Edema; Female; Freund's Adjuvant; Granuloma; Hyperalgesia; Indomethacin; Lipoxygenase Inhibitors; Mice; Pain Measurement; Pain Threshold; Pyrroles; Rats; Rats, Wistar; Time Factors; Touch	2006
Antithrombin reduces endotoxin-induced hypotension by enhancing pulmonary sensory neuron activation in rats. Thrombosis and haemostasis, 2006, Volume: 95, Issue:6 Topics: Animals; Antithrombins; Arachidonic Acids; Blood Pressure; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Capsaicin; Carbazoles; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinase Type II; Cyclic AMP-Dependent Protein Kinases; Cyclooxygenase Inhibitors; Disease Models, Animal; Endocannabinoids; Endotoxins; Ganglia, Spinal; Gene Expression Regulation; Hypotension; Indoles; Indomethacin; Lung; Male; Neurons, Afferent; Nitrates; Nitric Oxide Synthase Type II; Nitrites; Peptide Fragments; Polyunsaturated Alkamides; Protein Kinase Inhibitors; Pyrroles; Rats; Rats, Wistar; Receptors, Calcitonin Gene-Related Peptide; RNA, Messenger; TRPV Cation Channels; Tumor Necrosis Factor-alpha	2006
In vivo effects of amtolmetin guacyl on lipid peroxidation and antioxidant defence systems in different models of gastrointestinal injury. Autonomic & autacoid pharmacology, 2007, Volume: 27, Issue:1 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Disease Models, Animal; Ethanol; Gastric Mucosa; Gastrointestinal Diseases; Glycine; Indomethacin; Intestinal Mucosa; Lipid Peroxidation; Liver; Male; Pyrroles; Rats; Rats, Wistar	2007
Atrial natriuretic peptide reduces ischemia/reperfusion-induced spinal cord injury in rats by enhancing sensory neuron activation. The Journal of pharmacology and experimental therapeutics, 2007, Volume: 322, Issue:2 Topics: 6-Ketoprostaglandin F1 alpha; Anilides; Animals; Atrial Natriuretic Factor; Calcitonin Gene-Related Peptide; Capsaicin; Carbazoles; Cells, Cultured; Cinnamates; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Indoles; Indomethacin; Male; Neurons, Afferent; Peroxidase; Psychomotor Performance; Pyrroles; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Spinal Cord; Spinal Cord Diseases; TRPV Cation Channels; Tumor Necrosis Factor-alpha	2007
Prediction of the pharmacokinetics of atorvastatin, cerivastatin, and indomethacin using kinetic models applied to isolated rat hepatocytes. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Animals; Atorvastatin; Hepatocytes; Heptanoic Acids; Indomethacin; Male; Models, Biological; Pyridines; Pyrroles; Rats; Rats, Sprague-Dawley	2008
Indomethacin inhibits cell growth of medullary thyroid carcinoma by reducing cell cycle progression into S phase. Experimental biology and medicine (Maywood, N.J.), 2008, Volume: 233, Issue:11 Topics: Antineoplastic Agents; Apoptosis; Calcitonin; Carcinoembryonic Antigen; Carcinoma, Medullary; Cell Cycle; Cell Line; Cell Proliferation; Cyclooxygenase Inhibitors; Dinoprostone; Gene Expression; Humans; Indoles; Indomethacin; Phosphorylation; Pyrroles; Retinoblastoma Protein; S Phase; Sunitinib; Thyroid Neoplasms	2008
Atorvastatin restores the impaired vascular endothelium-dependent relaxations mediated by nitric oxide and endothelium-derived hyperpolarizing factors but not hypotension in sepsis. Journal of cardiovascular pharmacology, 2009, Volume: 54, Issue:6 Topics: Acetylcholine; Animals; Aorta; Atorvastatin; Biological Factors; Blood Cell Count; Blood Pressure; Calcium Channel Blockers; Cytochrome P-450 Enzyme Inhibitors; Disease Models, Animal; Endothelium, Vascular; Gene Expression; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypotension; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Nitroprusside; Phenylephrine; Pulmonary Artery; Pyrroles; Rats; Rats, Wistar; Sepsis; Vasodilation	2009
Pain is a salient "stressor" that is mediated by corticotropin-releasing factor-1 receptors. Neuropharmacology, 2010, Volume: 59, Issue:3 Topics: Aniline Compounds; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Corticotropin-Releasing Hormone; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Hyperalgesia; Indomethacin; Inflammation; Male; Mice; Pain; Pain Threshold; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; Spinal Cord Injuries; Stomach Ulcer; Stress, Psychological	2010
Synthesis of novel pyrrolyl-indomethacin derivatives. European journal of medicinal chemistry, 2012, Volume: 57 Topics: Actins; Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Cell Proliferation; Cell Survival; Delayed-Action Preparations; Esters; Histocytochemistry; Indomethacin; Injections, Intra-Articular; Male; Mice; Osteoblasts; Oxidation-Reduction; Primary Cell Culture; Pyrroles; Rats; Rats, Sprague-Dawley; Skull	2012
Concomitant beige adipocyte differentiation upon induction of mesenchymal stem cells into brown adipocytes. Biochemical and biophysical research communications, 2016, 09-16, Volume: 478, Issue:2 Topics: 1-Methyl-3-isobutylxanthine; Adipocytes, Beige; Adipocytes, Brown; Carbazoles; Cell Differentiation; Colforsin; Culture Media; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Dexamethasone; Gene Expression Regulation; Humans; Indomethacin; Insulin; Mesenchymal Stem Cells; Mitochondria; Primary Cell Culture; Pyrroles; RNA, Small Interfering; Triiodothyronine	2016
Kaempferol-induces vasorelaxation via endothelium-independent pathways in rat isolated pulmonary artery. Pharmacological reports : PR, 2018, Volume: 70, Issue:5 Topics: Animals; Apamin; Barium Compounds; Calcium Chloride; Chlorides; Dose-Response Relationship, Drug; Endothelium, Vascular; Estradiol; Fulvestrant; Glyburide; In Vitro Techniques; Indomethacin; Isoquinolines; Kaempferols; Male; Morpholines; NG-Nitroarginine Methyl Ester; Oxadiazoles; Peptides; Potassium; Pulmonary Artery; Pyrroles; Quinoxalines; Rats; Sulfonamides; Tetraethylammonium; Vasodilation; Vasodilator Agents	2018
Central Transient Receptor Potential Vanilloid 4 Contributes to Systemic Water Homeostasis through Urinary Excretion. Biological & pharmaceutical bulletin, 2019, Volume: 42, Issue:11 Topics: Animals; Atrial Natriuretic Factor; Dinoprost; Diuresis; Drinking; Homeostasis; Indomethacin; Male; Morpholines; Phorbol Esters; Pyrroles; Rats; Rats, Wistar; Ruthenium Red; TRPV Cation Channels; Urination; Vasopressins	2019
Gastric acid inhibitor aggravates indomethacin-induced small intestinal injury via reducing Lactobacillus johnsonii. Scientific reports, 2019, 11-25, Volume: 9, Issue:1 Topics: Animals; Disease Models, Animal; Dysbiosis; Fecal Microbiota Transplantation; High-Throughput Nucleotide Sequencing; Humans; Indomethacin; Injections, Intraperitoneal; Intestine, Small; Lactobacillus johnsonii; Male; Mice; Mice, Inbred C57BL; Proton Pump Inhibitors; Pyrroles; Rabeprazole; RNA, Ribosomal, 16S; Sequence Analysis, DNA; Sulfonamides	2019
Licofelone, a dual cyclooxygenase/5-lipoxygenase inhibitor, reverses endotoxin-induced impaired atrial chronotropic responsiveness to cholinergic stimulation in rats. European journal of pharmacology, 2020, Nov-15, Volume: 887 Topics: Animals; Anti-Inflammatory Agents; Arachidonate 5-Lipoxygenase; Carbachol; Cholinergic Agents; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Endotoxins; Heart Atria; Heart Rate; Hydrocortisone; Indomethacin; Lipopolysaccharides; Lipoxygenase Inhibitors; Male; Parasympathetic Nervous System; Pyrroles; Rats; Rats, Wistar	2020
The influence of different proton pump inhibitors and potassium-competitive acid blockers on indomethacin-induced small intestinal injury. Journal of gastroenterology and hepatology, 2022, Volume: 37, Issue:10 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Inflammatory Agents, Non-Steroidal; DNA, Ribosomal; Indomethacin; Intestinal Diseases; Intestinal Mucosa; Intestine, Small; Lipopolysaccharides; Mice; Omeprazole; Potassium; Proton Pump Inhibitors; Pyrroles; Rabeprazole; Sulfonamides	2022