Compounds > pyrroles

Page last updated: 2024-08-18

pyrroles and immucillin g

pyrroles has been researched along with immucillin g in 17 studies

Research

Studies (17)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	3 (17.65)	18.2507
2000's	11 (64.71)	29.6817
2010's	3 (17.65)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Bagdassarian, CK; Furneaux, RH; Miles, RW; Schramm, VL; Tyler, PC	1
Furneaux, RH; Girvin, ME; Grubmeyer, C; Kicska, G; Li, CM; Schramm, VL; Tyler, PC; Xu, Y	1
Almo, SC; Furneaux, RH; Grubmeyer, C; Li, CM; Schramm, VL; Shi, W; Tyler, PC	1
Almo, SC; Furneaux, RH; Grubmeyer, C; Li, CM; Munagala, NR; Schramm, VL; Shi, W; Tyler, PC; Wang, CC	1
Munagala, N; Sarver, AE; Wang, CC	1
Angeletti, RH; Grubmeyer, C; Nieves, E; Schramm, VL; Shi, W; Wang, F	1
Evans, GB; Furneaux, RH; Kicska, GA; Kim, K; Schramm, VL; Tyler, PC	1
Almo, SC; Cahill, SM; Evans, GB; Fedorov, A; Furneaux, RH; Kicska, GA; Lewandowicz, A; Schramm, VL; Shi, W; Tyler, PC	1
Almo, SC; Basso, LA; Evans, GB; Furneaux, RH; Lewandowicz, A; Santos, DS; Schramm, VL; Shi, W; Tyler, PC	1
Evans, GB; Furneaux, RH; Lewandowicz, A; Schramm, VL; Tyler, PC	1
Evans, GB; Furneaux, RH; Schramm, VL; Tyler, PC	1
Lewandowicz, A	1
Alvarez, R; Botta, M; Corelli, F; Focher, F; Ghiron, C; Lossani, A; Manetti, F; Mugnaini, C; Semeraro, T; Valensin, S	1
Delso, I; Merino, P; Tejero, T	1
Cassera, MB; Hazleton, KZ; Schramm, VL; Zhang, Y	1
Clinch, K; Evans, GB; Freitas, EO; Guan, R; Meyer-Fernandes, JR; Nico, D; Palatnik-de-Sousa, CB; Schramm, VL; Tyler, PC	1
Baldini, E; Bernardini, G; Jacomelli, G; Micheli, V; Mugnaini, C; Santucci, A	1

Reviews

3 review(s) available for pyrroles and immucillin g

Article	Year
[Tight binding transition state analogues of purine nucleoside phosphorylase--meaning, design and properties]. Postepy biochemii, 2004, Volume: 50, Issue:3 Topics: Animals; Enzyme Inhibitors; Humans; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; Structure-Activity Relationship	2004
Current developments in the synthesis and biological activity of aza-C-nucleosides: immucillins and related compounds. Current medicinal chemistry, 2008, Volume: 15, Issue:10 Topics: Adenine; Adenosine; Aza Compounds; Glycoside Hydrolases; N-Glycosyl Hydrolases; Nucleosides; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; Pyrrolidines	2008
Purine and pyrimidine pathways as targets in Plasmodium falciparum. Current topics in medicinal chemistry, 2011, Volume: 11, Issue:16 Topics: Antimalarials; Binding Sites; Drug Design; Enzyme Inhibitors; Humans; Malaria, Falciparum; Models, Molecular; Plasmodium falciparum; Protein Binding; Protozoan Proteins; Purine Nucleosides; Purines; Pyrimidines; Pyrimidinones; Pyrroles; Substrate Specificity	2011

Other Studies

14 other study(ies) available for pyrroles and immucillin g

Article	Year
One-third-the-sites transition-state inhibitors for purine nucleoside phosphorylase. Biochemistry, 1998, Jun-16, Volume: 37, Issue:24 Topics: Animals; Cattle; Enzyme Inhibitors; Humans; Kinetics; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; Structure-Activity Relationship; Substrate Specificity; T-Lymphocytes	1998
Transition-state analogs as inhibitors of human and malarial hypoxanthine-guanine phosphoribosyltransferases. Nature structural biology, 1999, Volume: 6, Issue:6 Topics: Animals; Binding Sites; Catalysis; Diphosphates; Drug Design; Enzyme Inhibitors; Guanosine Monophosphate; Humans; Hydrogen Bonding; Hypoxanthine; Hypoxanthine Phosphoribosyltransferase; Inosine Monophosphate; Kinetics; Magnesium Compounds; Nuclear Magnetic Resonance, Biomolecular; Phosphoribosyl Pyrophosphate; Phosphorylation; Plasmodium falciparum; Protein Binding; Protons; Purine Nucleosides; Pyrimidinones; Pyrroles	1999
The 2.0 A structure of human hypoxanthine-guanine phosphoribosyltransferase in complex with a transition-state analog inhibitor. Nature structural biology, 1999, Volume: 6, Issue:6 Topics: Binding Sites; Catalytic Domain; Crystallization; Crystallography, X-Ray; Diphosphates; Electrons; Enzyme Inhibitors; Humans; Hydrogen Bonding; Hypoxanthine Phosphoribosyltransferase; Ions; Magnesium; Magnesium Compounds; Models, Molecular; Molecular Sequence Data; Nitrogen; Oxygen; Phosphates; Protein Binding; Protein Structure, Secondary; Pyrimidinones; Pyrroles; Solvents	1999
Crystal structures of Giardia lamblia guanine phosphoribosyltransferase at 1.75 A(,). Biochemistry, 2000, Jun-13, Volume: 39, Issue:23 Topics: Animals; Binding Sites; Crystallography, X-Ray; Dimerization; Enzyme Inhibitors; Giardia lamblia; Hypoxanthine Phosphoribosyltransferase; Models, Molecular; Molecular Conformation; Pyrimidinones; Pyrroles; Recombinant Proteins	2000
Converting the guanine phosphoribosyltransferase from Giardia lamblia to a hypoxanthine-guanine phosphoribosyltransferase. The Journal of biological chemistry, 2000, Nov-24, Volume: 275, Issue:47 Topics: Amino Acid Sequence; Animals; Binding Sites; Crystallography, X-Ray; Giardia lamblia; Giardiasis; Humans; Hypoxanthine Phosphoribosyltransferase; Kinetics; Magnesium; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphates; Protein Conformation; Pyrimidinones; Pyrroles; Structure-Activity Relationship	2000
A transition-state analogue reduces protein dynamics in hypoxanthine-guanine phosphoribosyltransferase. Biochemistry, 2001, Jul-10, Volume: 40, Issue:27 Topics: Amino Acid Sequence; Binding Sites; Catalytic Domain; Chromatography, High Pressure Liquid; Deuterium; Diphosphates; Enzyme Inhibitors; Humans; Hypoxanthine Phosphoribosyltransferase; Isoleucine; Leucine; Macromolecular Substances; Magnesium; Magnesium Compounds; Mass Spectrometry; Molecular Sequence Data; Pepsin A; Peptide Fragments; Phenylalanine; Protons; Pyrimidinones; Pyrroles	2001
Purine-less death in Plasmodium falciparum induced by immucillin-H, a transition state analogue of purine nucleoside phosphorylase. The Journal of biological chemistry, 2002, Feb-01, Volume: 277, Issue:5 Topics: Animals; Biological Transport; Cell Death; Enzyme Inhibitors; Erythrocytes; Humans; Hypoxanthine; Kinetics; Models, Biological; Plasmodium falciparum; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Purines; Pyrimidinones; Pyrroles; Time Factors	2002
Atomic dissection of the hydrogen bond network for transition-state analogue binding to purine nucleoside phosphorylase. Biochemistry, 2002, Dec-10, Volume: 41, Issue:49 Topics: Animals; Asparagine; Binding Sites; Catalysis; Cattle; Crystallography, X-Ray; Enzyme Inhibitors; Glutamic Acid; Hydrogen Bonding; Hydrogen-Ion Concentration; Hypoxanthine; Imines; Nuclear Magnetic Resonance, Biomolecular; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; Ribonucleosides; Static Electricity; Substrate Specificity; Thermodynamics	2002
Over-the-barrier transition state analogues and crystal structure with Mycobacterium tuberculosis purine nucleoside phosphorylase. Biochemistry, 2003, May-27, Volume: 42, Issue:20 Topics: Catalytic Domain; Crystallography, X-Ray; Inosine; Kinetics; Models, Molecular; Molecular Mimicry; Mycobacterium tuberculosis; Protein Conformation; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; Static Electricity; Substrate Specificity	2003
Exploring structure-activity relationships of transition state analogues of human purine nucleoside phosphorylase. Journal of medicinal chemistry, 2003, Jul-17, Volume: 46, Issue:15 Topics: Animals; Cattle; Enzyme Inhibitors; Humans; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; Structure-Activity Relationship	2003
Synthesis of a transition state analogue inhibitor of purine nucleoside phosphorylase via the Mannich reaction. Organic letters, 2003, Oct-02, Volume: 5, Issue:20 Topics: Amines; Enzyme Inhibitors; Humans; Purine-Nucleoside Phosphorylase; Purines; Pyrimidinones; Pyrroles	2003
Simplified analogues of immucillin-G retain potent human purine nucleoside phosphorylase inhibitory activity. Journal of medicinal chemistry, 2006, Oct-05, Volume: 49, Issue:20 Topics: Antineoplastic Agents; Cell Line; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Piperidines; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; Pyrrolidines; Structure-Activity Relationship	2006
Immucillins Impair Leishmania (L.) infantum chagasi and Leishmania (L.) amazonensis Multiplication In Vitro. PloS one, 2015, Volume: 10, Issue:4 Topics: Adenine; Adenosine; Animals; Antiprotozoal Agents; Cell Proliferation; Enzyme Inhibitors; Female; Humans; In Vitro Techniques; Kinetics; Leishmania infantum; Leishmania mexicana; Leishmaniasis, Cutaneous; Leishmaniasis, Visceral; Mice; Mice, Inbred BALB C; Microscopy, Electron, Transmission; N-Glycosyl Hydrolases; Purine Nucleosides; Pyrimidinones; Pyrroles; Pyrrolidines	2015
Inhibiting PNP for the therapy of hyperuricemia in Lesch-Nyhan disease: Preliminary in vitro studies with analogues of immucillin-G. Journal of inherited metabolic disease, 2019, Volume: 42, Issue:1 Topics: Allopurinol; Cells, Cultured; Enzyme Inhibitors; Humans; Hyperuricemia; Hypoxanthine; Hypoxanthine Phosphoribosyltransferase; Lesch-Nyhan Syndrome; Purine-Nucleoside Phosphorylase; Purines; Pyrimidinones; Pyrroles; Reproducibility of Results; Uric Acid; Xanthine	2019