pyrroles has been researched along with hymenialdisine in 30 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (10.00) | 18.2507 |
| 2000's | 11 (36.67) | 29.6817 |
| 2010's | 12 (40.00) | 24.3611 |
| 2020's | 4 (13.33) | 2.80 |
| Authors | Studies |
|---|---|
| Breton, JJ; Chabot-Fletcher, MC | 1 |
| Chabot-Fletcher, M; Jackson, JR; Marshall, LA; Roshak, A | 1 |
| Badger, AM; Cook, MN; Gowen, M; Lark, M; Newman-Tarr, TM; Swift, BA | 1 |
| Biernat, J; Cleverley, KE; Garnier, M; Kim, SH; Mandelkow, EM; Meijer, L; Nikolic, M; Pettit, GR; Salinas, PC; Thunnissen, AM; Tsai, LH; Walter, J; White, AW; Wu, YZ | 1 |
| Collins, K; Concepción, GP; Feldberg, LR; Greenstein, M; Harper, MK; Ireland, CM; Kim, SC; Mallon, R; Mangalindan, GC; Tasdemir, D; Wojciechowicz, D | 1 |
| Elcock, AH; Rockey, WM | 1 |
| Biernat, J; Mandelkow, E; Mandelkow, EM; Meijer, L; Timm, T; Wu, YZ; Zheng-Fischhöfer, Q | 1 |
| Adrian, FJ; Bach, S; Cho, CY; Fabbro, D; Gray, NS; Hur, W; Liu, Y; Lozach, O; Mayer, T; Meijer, L; Wan, Y | 1 |
| Jin, G; Lansdell, TA; Sharma, V; Tepe, JJ | 1 |
| Sharma, V; Tepe, JJ | 1 |
| Borghi, D; Papeo, G; Posteri, H; Varasi, M | 1 |
| Brady, HJ; Caldicott, A; Crescenzi, E; Dransfield, I; Duffin, R; Gray, M; Haslett, C; Martin, MC; Martinez-Losa, M; Riley, NA; Rossi, AG; Savill, JS; Sawatzky, DA; Sheldrake, TA; Walker, A; Walker, TR; Ward, C | 1 |
| De Nanteuil, G; Gloanec, P; Golsteyn, RM; Hickman, J; Parmentier, JG; Pierré, A; Portevin, B | 1 |
| Nguyen, TN; Tepe, JJ | 1 |
| Jiang, Y; Yan, H; Zhang, N; Zhong, R | 1 |
| Cao, XP; Qu, Y; Song, YF; Zhang, W | 1 |
| Bayer, M; Dobretsov, S; Gunasekera, S; Paul, VJ; Proksch, P; Teplitski, M | 1 |
| Henry, RW; Hovde, S; Luderer, MJ; Nguyen, TN; Saleem, RS; Tepe, JJ | 1 |
| Carpenter, N; Lottin, JR; McClelland, RA; Nicholson, RI; White, AW | 1 |
| Long, M; Zhou, SW | 1 |
| Andersen, RJ; Beglov, D; Hall, DR; Kozakov, D; Pelletier, J; Shin, U; Vajda, S; Williams, DE | 1 |
| Alfonso, A; Alonso, E; Botana, LM; Ebel, R; Houssen, WE; Jaspars, M; Leirós, M; Rateb, ME | 1 |
| Bai, BM; Kumar, A; Nisha, CM; Pal, D; Vimal, A | 1 |
| Fu, P; Huang, YZ; Li, HL; Shen, JY; Xiong, NX; Zhao, HY; Zuo, YC | 1 |
| Agrawal, K; Annadurai, N; Das, V; Džubák, P; Hajdúch, M | 1 |
| Abbaszadeh, S; Asadi-Samani, M; Ashrafi-Dehkordi, K; Basati, G; Saffari-Chaleshtori, J | 1 |
| Chen, D; Chen, K; Chen, P; Davis, RA; Jin, H; Kuek, V; Liu, Q; Qiu, H; Song, D; Song, F; Wang, C; Wang, Q; Xu, J; Xu, K; Ye, Z; Zhao, J | 1 |
| Cao, X; Linhardt, RJ; Qu, Y; Song, Y; Yang, Q; Zhang, F; Zhang, W | 1 |
| Abdullah, N; Al Bahlani, S; Al Balushi, N; Burney, IA; Dobretsov, S; Hasan, SI; Tamimi, Y | 1 |
| Aoyama, Y; Hayashi, Y; Imafuji, H; Kato, T; Kimura, M; Matsuo, Y; Mitsui, A; Morimoto, M; Murase, H; Ogawa, R; Omi, K; Saito, K; Takahashi, H; Takiguchi, S; Tsuboi, K; Ueda, G | 1 |
3 review(s) available for pyrroles and hymenialdisine
| Article | Year |
|---|---|
Preparation of hymenialdisine, analogues and their evaluation as kinase inhibitors.
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Azepines; Molecular Conformation; Porifera; Protein Kinase Inhibitors; Pyrroles; Structure-Activity Relationship | 2009 |
[Advances in the studies of glycogen synthase kinase-3 and diabetes].
Topics: Animals; Azepines; Diabetes Mellitus; Glucose; Glycogen Synthase Kinase 3; Humans; Pyrroles | 2012 |
Microtubule affinity-regulating kinases are potential druggable targets for Alzheimer's disease.
Topics: Alzheimer Disease; Antigens, Bacterial; Azepines; Bacterial Proteins; Humans; Methylene Blue; Neurons; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrazoles; Pyridines; Pyrroles; Staurosporine; tau Proteins | 2017 |
27 other study(ies) available for pyrroles and hymenialdisine
| Article | Year |
|---|---|
The natural product hymenialdisine inhibits interleukin-8 production in U937 cells by inhibition of nuclear factor-kappaB.
Topics: Azepines; Humans; Interleukin-8; Luciferases; NF-kappa B; Proto-Oncogene Proteins; Pyrroles; RNA, Messenger; Transcription Factor RelB; Transcription Factors; Tumor Cells, Cultured | 1997 |
Inhibition of NFkappaB-mediated interleukin-1beta-stimulated prostaglandin E2 formation by the marine natural product hymenialdisine.
Topics: Adult; Arthritis, Rheumatoid; Azepines; Cells, Cultured; Dinoprostone; Endothelial Growth Factors; Humans; Interleukin-1; Interleukin-8; Lymphokines; NF-kappa B; Phospholipases A; Phospholipases A2; Prostaglandin-Endoperoxide Synthases; Pyrroles; Synovial Membrane; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1997 |
Inhibition of interleukin-1-induced proteoglycan degradation and nitric oxide production in bovine articular cartilage/chondrocyte cultures by the natural product, hymenialdisine.
Topics: Animals; Azepines; Benzoquinones; Blotting, Northern; Cartilage, Articular; Cattle; Cells, Cultured; Chondrocytes; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Indicators and Reagents; Interleukin-1; Lactams, Macrocyclic; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Protein Kinase C; Protein-Tyrosine Kinases; Proteoglycans; Pyrroles; Quinones; Rifabutin; RNA; Sulfates; Tretinoin | 1999 |
Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent.
Topics: Adenosine Triphosphate; Animals; Azepines; Calcium-Calmodulin-Dependent Protein Kinases; Casein Kinases; Cerebellum; Crystallization; Crystallography, X-Ray; Cyclin-Dependent Kinases; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Microtubule-Associated Proteins; Molecular Conformation; Neurons; Phosphorylation; Porifera; Protein Kinase Inhibitors; Protein Kinases; Pyrroles; tau Proteins | 2000 |
Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1).
Topics: Animals; Antineoplastic Agents; Azepines; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Humans; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Philippines; Phosphorylation; Porifera; Protein Serine-Threonine Kinases; Pyrroles; Structure-Activity Relationship; Tumor Cells, Cultured | 2002 |
Progress toward virtual screening for drug side effects.
Topics: Adenosine Diphosphate; Algorithms; Azepines; Benzamides; Binding Sites; Computational Biology; Computer Simulation; Drug Delivery Systems; Enzyme Inhibitors; Guanosine Diphosphate; Imatinib Mesylate; Models, Molecular; Piperazines; Protein Binding; Protein Kinases; Pyrimidines; Pyrroles; Receptors, Drug; Receptors, Purinergic P2; Sensitivity and Specificity; Static Electricity | 2002 |
Protein kinase MARK/PAR-1 is required for neurite outgrowth and establishment of neuronal polarity.
Topics: Amino Acid Motifs; Animals; Azepines; Cell Line; Cell Polarity; Enzyme Inhibitors; Flavonoids; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Mice; Neurites; Neurons; Piperidines; Protein Serine-Threonine Kinases; Pyrroles; Recombinant Fusion Proteins; Signal Transduction; tau Proteins | 2002 |
Synthesis and target identification of hymenialdisine analogs.
Topics: Amino Acid Sequence; Azepines; Chromatography, Affinity; Enzyme Inhibitors; Molecular Sequence Data; Phosphotransferases; Pyrroles; Structure-Activity Relationship | 2004 |
Inhibition of cytokine production by hymenialdisine derivatives.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Azepines; Cell Line, Tumor; Crystallography, X-Ray; Cytokines; Humans; Indoles; Interleukin-2; Molecular Structure; Pyrroles; Structure-Activity Relationship; Tumor Necrosis Factor-alpha | 2004 |
Potent inhibition of checkpoint kinase activity by a hymenialdisine-derived indoloazepine.
Topics: Azepines; Checkpoint Kinase 2; Enzyme Inhibitors; Protein Serine-Threonine Kinases; Pyrroles | 2004 |
A new glycociamidine ring precursor: syntheses of (Z)-hymenialdisine, (Z)-2-debromohymenialdisine, and (+/-)-endo-2-debromohymenialdisine.
Topics: Alkaloids; Animals; Azepines; Cyclization; Marine Biology; Molecular Structure; Porifera; Pyrroles; Stereoisomerism | 2005 |
Cyclin-dependent kinase inhibitors enhance the resolution of inflammation by promoting inflammatory cell apoptosis.
Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Azepines; Carrageenan; Caspase 3; Cyclin-Dependent Kinases; Enzyme Inhibitors; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Inflammation; Male; Mice; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Neutrophils; Pleurisy; Proto-Oncogene Proteins c-bcl-2; Purines; Pyrroles; Roscovitine | 2006 |
Synthesis and CHK1 inhibitory potency of Hymenialdisine analogues.
Topics: Antineoplastic Agents; Azepines; Checkpoint Kinase 1; Chemistry, Pharmaceutical; Drug Design; Drug Screening Assays, Antitumor; Electrons; Humans; Inhibitory Concentration 50; Models, Chemical; Molecular Structure; Neoplasms; Protein Kinases; Pyrroles; Structure-Activity Relationship; Thiophenes | 2009 |
Structural features underlying selective inhibition of GSK3β by dibromocantharelline: implications for rational drug design.
Topics: Amino Acid Sequence; Animals; Azepines; Binding Sites; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 5; Drug Design; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Indole Alkaloids; Molecular Dynamics Simulation; Molecular Sequence Data; Porifera; Protein Kinase Inhibitors; Pyrroles; Software | 2011 |
Cellular localization of debromohymenialdisine and hymenialdisine in the marine sponge Axinella sp. using a newly developed cell purification protocol.
Topics: Animals; Azepines; Bacteria; Cell Separation; Porifera; Protein Transport; Pyrroles | 2011 |
Inhibition of marine biofouling by bacterial quorum sensing inhibitors.
Topics: Animals; Antibiotics, Antineoplastic; Azepines; Biofouling; Biological Products; Chromobacterium; Oligopeptides; Pigments, Biological; Pyrones; Pyrroles; Pyrrolidines; Quorum Sensing; Tenuazonic Acid | 2011 |
Radioprotection by hymenialdisine-derived checkpoint kinase 2 inhibitors.
Topics: Apoptosis; Azepines; Cell Cycle; Cell Line; Cell Survival; Checkpoint Kinase 2; DNA Damage; DNA Repair; Dose-Response Relationship, Drug; Humans; Models, Molecular; Mutation; Phosphorylation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrroles; Radiation-Protective Agents; Radiation, Ionizing; Serine; Signal Transduction; Tumor Suppressor Protein p53 | 2012 |
Synthesis and evaluation of novel anti-proliferative pyrroloazepinone and indoloazepinone oximes derived from the marine natural product hymenialdisine.
Topics: Antineoplastic Agents; Azepines; Biological Products; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Indoles; MCF-7 Cells; Molecular Structure; Oximes; Pyrroles; Structure-Activity Relationship | 2012 |
Stimulators of translation identified during a small molecule screening campaign.
Topics: Adenosine Triphosphate; Azepines; Drug Evaluation, Preclinical; eIF-2 Kinase; High-Throughput Screening Assays; Models, Molecular; Protein Biosynthesis; Protein Conformation; Pyrroles; Small Molecule Libraries | 2014 |
Bromoalkaloids protect primary cortical neurons from induced oxidative stress.
Topics: Alkaloids; Animals; Antioxidant Response Elements; Azepines; Blotting, Western; Cell Membrane; Cell Survival; Cells, Cultured; Cerebral Cortex; Lipid Peroxidation; Mice; Microscopy, Confocal; Mitochondria; Neurons; Neuroprotective Agents; NF-E2-Related Factor 2; Oxidative Stress; Pyrroles; Sesquiterpenes; Signal Transduction | 2015 |
Docking and ADMET prediction of few GSK-3 inhibitors divulges 6-bromoindirubin-3-oxime as a potential inhibitor.
Topics: Azepines; Binding Sites; Glycogen Synthase Kinase 3 beta; Humans; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Hypoglycemic Agents; Indole Alkaloids; Indoles; Ligands; Molecular Docking Simulation; Molecular Dynamics Simulation; Oximes; Protein Binding; Protein Interaction Domains and Motifs; Protein Kinase Inhibitors; Protein Structure, Secondary; Pyrroles; Static Electricity; Thermodynamics; Thiadiazoles | 2016 |
Overexpression of Tau Rescues Nogo-66-Induced Neurite Outgrowth Inhibition In Vitro.
Topics: Analysis of Variance; Animals; Azepines; Cells, Cultured; Cerebral Cortex; Embryo, Mammalian; Enzyme Inhibitors; Female; Gene Expression Regulation; Green Fluorescent Proteins; Humans; Mice; Neurites; Neuroblastoma; Neurons; Nogo Proteins; Protein Serine-Threonine Kinases; Pyrroles; Rats; Rats, Sprague-Dawley; tau Proteins; Time Factors; Transfection | 2016 |
Molecular Dynamics Mechanisms of the Inhibitory Effects of Abemaciclib, Hymenialdisine, and Indirubin on CDK-6.
Topics: Aminopyridines; Antineoplastic Agents; Azepines; Benzimidazoles; Binding Sites; Cell Cycle Checkpoints; Computer Simulation; Cyclin-Dependent Kinase 6; Humans; Hydrogen Bonding; Indoles; Models, Molecular; Molecular Docking Simulation; Molecular Dynamics Simulation; Protein Kinase Inhibitors; Pyrroles | 2019 |
Hymenialdisine: A Marine Natural Product That Acts on Both Osteoblasts and Osteoclasts and Prevents Estrogen-Dependent Bone Loss in Mice.
Topics: Animals; Azepines; Biological Products; Bone Resorption; Cell Differentiation; Estrogens; Female; Glycogen Synthase Kinase 3; Mice; Mice, Inbred C57BL; NF-kappa B; NFATC Transcription Factors; Osteoblasts; Osteoclasts; Osteogenesis; Osteolysis; Pyrroles; RANK Ligand | 2020 |
Cultivation of fractionated cells from a bioactive-alkaloid-bearing marine sponge Axinella sp.
Topics: Animals; Axinella; Azepines; Cell Fractionation; Cells, Cultured; Pyrroles | 2021 |
Hymenialdisine is Cytotoxic Against Cisplatin-Sensitive but Not Against Cisplatin-Resistant Cell Lines.
Topics: Azepines; Cell Line, Tumor; Cisplatin; Drug Resistance, Neoplasm; Humans; Ovarian Neoplasms; Pyrroles | 2021 |
10Z‑Hymenialdisine inhibits angiogenesis by suppressing NF‑κB activation in pancreatic cancer cell lines.
Topics: Angiogenesis Inhibitors; Animals; Azepines; Cell Line, Tumor; Disease Models, Animal; Humans; Mice; Neovascularization, Pathologic; NF-kappa B; Pancreatic Neoplasms; Pyrroles | 2022 |