pyrroles has been researched along with gx 15-070 in 173 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 24 (13.87) | 29.6817 |
| 2010's | 138 (79.77) | 24.3611 |
| 2020's | 11 (6.36) | 2.80 |
| Authors | Studies |
|---|---|
| Shore, GC; Viallet, J | 1 |
| Barragán, M; Campàs, C; Coll-Mulet, L; Cosialls, AM; de Frias, M; Domingo, A; Gil, J; Iglesias-Serret, D; Pons, G; Santidrián, AF | 1 |
| Berger, M; Lipton, A; Planas-Silva, MD; Viallet, J; Witkoski, A; Witters, LM | 1 |
| Campo, E; Colomer, D; Pérez-Galán, P; Roué, G; Villamor, N | 1 |
| Li, ZH; Rauw, J; Stewart, AK; Tiedemann, RE; Trudel, S; Wen, XY | 1 |
| Haura, EB; Li, J; Viallet, J | 1 |
| Acoca, S; Beauparlant, P; Bélec, L; Billot, X; Cluse, L; Goulet, D; Johnstone, RW; Marcellus, RC; Murthy Madiraju, SR; Nguyen, M; Purisima, E; Roulston, A; Serfass, L; Shore, GC; Viallet, J; Watson, M; Wiegmans, A | 1 |
| Chen, J; Dong, S; Kang, S; Khoury, HJ; Lonial, S; Viallet, J | 1 |
| Andreeff, M; Bornmann, W; Contractor, R; Estrov, Z; Harris, D; Kantarjian, H; Konopleva, M; Samudio, I; Tsao, T; Viallet, J; Watt, J | 1 |
| Campo, E; Colomer, D; López-Guerra, M; Montserrat, E; Nguyen, M; Pérez-Galán, P; Roué, G; Shore, GC; Villamor, N | 1 |
| Marzo, I; Naval, J | 1 |
| Bronk, SF; Gores, GJ; Kaufmann, SH; Mesa, RA; Mott, JL | 1 |
| Azmi, AS; Mohammad, RM | 1 |
| Cheson, BD; Claxton, DF; Crump, M; Faderl, S; Keating, MJ; Kipps, T; O'Brien, SM; Viallet, J | 1 |
| Lin, TS | 1 |
| Andreeff, M; Berger, M; Borthakur, G; Brandwein, J; Chang, H; Cheson, BD; Giles, F; Gupta, V; Kamel-Reid, S; Kantarjian, H; Koller, C; Minden, MD; O'Brien, S; Ravandi, F; Schimmer, AD; Schuh, A; Viallet, J; Yee, K | 1 |
| Huang, S; Okumura, K; Sinicrope, FA | 1 |
| Kang, MH; Reynolds, CP | 1 |
| Letai, A; Ni Chonghaile, T | 1 |
| Hutcheson, J; Perlman, H | 1 |
| Hersey, P; Jiang, CC; Wroblewski, D; Yang, F; Zhang, XD | 1 |
| Dent, P; Grant, S; Martin, AP; Mitchell, C; Nephew, KP; Rahmani, M | 1 |
| Amaravadi, R | 1 |
| Cao, Q; Chen, Q; Cheng, C; Jin, Y; Pan, J; Verstovsek, S | 1 |
| Blechacz, BR; Bronk, SF; Gores, GJ; Sinicrope, FA; Sirica, AE; Smoot, RL; Werneburg, NW | 1 |
| Brown, A; Ginsberg, MS; James, L; Juergens, R; Kris, MG; Krug, LM; Markus, S; Paik, PK; Rizvi, NA; Rudin, CM; Subzwari, S; Takebe, N; Travis, W; Tyson, L | 1 |
| Bonapace, L; Bornhauser, BC; Bourquin, JP; Cario, G; Niggli, FK; Schäfer, BW; Schmitz, M; Schrappe, M; Stanulla, M; Ziegler, U | 1 |
| Pérez-Tomás, R; Viñas, M | 1 |
| Fulda, S; Galluzzi, L; Kroemer, G | 1 |
| Bhatia, M; Campbell, CJ; Leber, B; Lee, JB; Levadoux-Martin, M; Wynder, T; Xenocostas, A | 1 |
| Garcia-Manero, G; Hu, Y; Jia, Y; Kadia, T; O'Brien, S; Tambaro, FP; Tong, W; Viallet, J; Wei, Y; Yang, H; Zhang, M | 1 |
| Berger, MS; Deeken, JF; Hwang, JJ; Kuruvilla, J; Marshall, JL; Mendelson, D; Pishvaian, MJ; Siu, LL; Viallet, J | 1 |
| Asatiani, E; El-Shami, K; Kantarjian, H; Parikh, SA; Schimmer, A; Verstovsek, S; Walsh, W; Winton, E | 1 |
| Garcia-Manero, G; Hu, Y; Jia, Y; Kadia, T; O'Brien, S; Tong, W; Viallet, J; Wei, Y; Yang, H; Zhang, M | 1 |
| Andrews, DW; Geng, F; Kale, J; Leber, B | 1 |
| Bell, J; Hiscott, J; Nguyên, TL; Oliere, S; Samuel, S; Shamy, A; Tumilasci, VF | 1 |
| Bareford, MD; Dent, P; Eulitt, P; Hossein, H; Martin, AP; Mitchell, C; Nephew, KP; Yacoub, A; Yang, C | 1 |
| Bornhauser, B; Bourquin, JP | 1 |
| Chacko, AD; Crawford, N; Fennell, DA; Longley, DB; McCoy, F; Redmond, K; Savage, KI | 1 |
| Harada, H; Heidari, N; Hicks, MA | 1 |
| Barnes, C; Fennell, DA; Hurwitz, J; Longley, D; McCoy, F; McKerr, G; McTavish, N; Murray, J; O'Hagan, B; Odrzywol, K; Paul, I | 1 |
| Berger, M; Blackhall, F; Cummings, J; Dean, EJ; Dive, C; Ranson, M; Roulston, A | 1 |
| Bhat, S; Brem, EA; Campagna, R; Czuczman, MS; Deeb, G; Fetterly, G; Gibbs, JF; Gu, J; Hernandez-Ilizaliturri, FJ; Hoskin, P; Iqbal, A; Khubchandani, S; Knight, J; Mavis, C; Olejniczak, SH; Riaz, W; Thudium, K; Tsai, PC | 1 |
| Brown, A; Ginsberg, MS; James, L; Juergens, R; Kris, MG; Krug, LM; Markus, S; Paik, PK; Pietanza, MC; Rizvi, NA; Rudin, CM; Subzwari, S; Takebe, N; Travis, W; Tyson, L | 1 |
| Acoca, S; Cui, Q; Purisima, EO; Shore, GC | 1 |
| Bollard, CM; Buglio, D; Derenzini, E; Illés, A; Ji, Y; Jóna, A; Khaskhely, N; Medeiros, LJ; Shafer, JA; Younes, A | 1 |
| Baritaki, S; Bonavida, B; González-Bonilla, C; Huerta-Yepez, S; Martínez-Paniagua, MA; Ortiz-Navarrete, VF; Vega, MI | 1 |
| Huang, DC; Khaw, SL; Roberts, AW | 1 |
| Armeanu-Ebinger, S; Ellerkamp, V; Fuchs, J; Kirchner, B; Lieber, J; Warmann, SW; Wenz, J | 1 |
| Díaz de Greñu, B; Espona, M; Iglesias Hernández, P; Light, ME; Pérez-Tomás, R; Quesada, R; Quiñonero, D; Torroba, T | 1 |
| Espona-Fiedler, M; Gao, T; Guallar, V; Hosseini, A; Lizcano, JM; Pérez-Tomás, R; Quesada, R; Soto-Cerrato, V | 1 |
| Cruickshanks, N; Dent, P; Fisher, PB; Grant, S; Hamed, HA; Tang, Y | 1 |
| Addya, S; Audia, A; Calabretta, B; Cattelani, S; Ferrari-Amorotti, G; Fragliasso, V; Holyoake, TL; Lidonnici, MR; Manzotti, G; Mariani, SA; Perini, G; Peterson, L; Soliera, AR | 1 |
| Claxton, D; Joudeh, J | 1 |
| Berger, MS; Blakely, J; Chiappori, AA; Chu, QS; Moezi, MM; Ross, HJ; Salgia, R; Schnyder, J; Schreeder, MT; Stephenson, JJ; Subramaniam, DS | 1 |
| Bareford, MD; Cruickshanks, N; Dent, P; Fisher, PB; Grant, S; Hamed, HA; Poklepovic, A | 1 |
| Mullard, A | 1 |
| Copeland, A; Fanale, M; Fayad, LE; Hagemeister, F; Oki, Y; Romaguera, J; Younes, A | 1 |
| Attkisson, E; Dasmahapatra, G; Dent, P; Fisher, RI; Friedberg, JW; Grant, S; Lembersky, D; Patel, H; Peterson, D; Son, MP | 1 |
| Basaga, H; Bodur, C | 1 |
| Buet, D; Denis, N; Dusanter-Fourt, I; Gallais, I; Guillonneau, F; Guillouf, C; Kosmider, O; Lauret, E; Loew, D; Lombard, B; Mayeux, P; Moreau-Gachelin, F | 1 |
| Attkisson, E; Aust, MM; Ferreira-Gonzalez, A; Grant, S; Rahmani, M; Williams, DC | 1 |
| Chen, KC; Chen, KF; Chen, WL; Huang, JW; Liu, CY; Shiau, CW; Su, JC; Tai, WT | 1 |
| Billard, C | 2 |
| Al-Harbi, S; Almasan, A; Choudhary, GS; Mazumder, S | 1 |
| Davids, MS; Letai, A | 1 |
| Chen, S; Dai, Y; Dent, P; Garnett, M; Grant, S; Kramer, LB; Larsen, DG; Myers, J; Orlowski, RZ; Pei, XY; Richey, JD; Schwartz, DM; Simmons, GL; Su, F; Wang, L | 1 |
| Giaccone, G; Killian, KJ; Lee, C; Lee, HS; Luo, J; Meltzer, PS; Petrini, I; Roncalli, M; Santoro, A; Steinberg, SM; Tsokos, M; Wang, Y; Zucali, PA | 1 |
| Ahola, T; Aittokallio, T; De Brabander, JK; Denisova, OV; Elliott, RM; Feng, L; Hukkanen, V; Julkunen, I; Kainov, DE; Kakkola, L; Kallio-Kokko, H; Kantele, A; Kaukinen, P; Kuivanen, S; Lampe, J; Nagaraj, A; Paavilainen, H; Saelens, X; Stenman, J; Tynell, J; Vapalahti, O; Yadav, B | 1 |
| Chen, KF; Chen, PJ; Chen, WL; Huang, JW; Kim, I; Liu, CY; Shiau, CW; Su, JC; Tai, WT | 1 |
| Booth, L; Cruickshanks, N; Dent, P; Grant, S; Hamed, H; Tang, Y | 1 |
| Ashton, JM; Becker, MW; Brookes, PS; Callahan, K; Grose, V; Jordan, CT; Lagadinou, ED; Liesveld, JL; Minhajuddin, M; Neering, SJ; O'Dwyer, KM; Pei, S; Rossi, RM; Sach, A | 1 |
| Atlas, SR; Bantly, AD; Barrett, JS; Cao, K; Carroll, AJ; Chen, IM; Cory, L; Devidas, M; Dreyer, ZE; Edwards, AY; Felix, CA; Heerema, NA; Hilden, JM; Hudome, A; Hunger, SP; Kundu, M; Moore, JS; Reaman, GH; Robinson, BW; Urtishak, KA; Wang, LS; Willman, CL; Yu, QC | 1 |
| Abu-Asab, M; Clarke, R; Cook, KL; Schwartz-Roberts, JL; Shajahan, AN; Wärri, A | 1 |
| Armeanu-Ebinger, S; Dewerth, A; Fuchs, J; Hoh, A; Lieber, J; Vogt, F | 1 |
| Bora-Singhal, N; Chellappan, SP; Kroeger, J; Laklai, H; Singh, S | 1 |
| Andreu-Fernández, V; Genovés, A; Messeguer, A; Orzáez, M; Pérez-Payá, E; Sancho, M | 1 |
| Hahn, PJ; Halleran, DR; Hudson, SG; Hutchison, RE; Nevaldine, B; Shapiro, A | 1 |
| Chumduri, C; Daniel, PT; Dörken, B; Müller, A; Scholz, CW; Zang, C | 1 |
| Abesada, G; Belgnaoui, SM; Beljanski, V; Ben Yebdri, F; Brown, D; Goulet, ML; Haddad, EK; He, Z; Hiscott, J; Nichols, C; Richards, S; Samuel, S; Shamy, A; Steel, C; Van Grevenynghe, J | 1 |
| Basit, F; Cristofanon, S; Fulda, S | 1 |
| Gruidl, M; Timme, CR; Yeatman, TJ | 1 |
| Douglass, AN; Kain, HS; Kappe, SH; Kaushansky, A; Lakshmanan, V; Metzger, PG; Mikolajczak, SA | 1 |
| Oberst, A | 1 |
| Liu, S; Yu, L | 1 |
| Booth, L; Cruickshanks, N; Dent, P; Grant, S; Hamed, HA; Poklepovic, A; Sajithlal, GB; Syed, J; Tavallai, S | 1 |
| Baumgartner, S; Cerny-Reiterer, S; Eisenwort, G; Gleixner, KV; Hadzijusufovic, E; Hoermann, G; Kundi, M; Mayerhofer, M; Peter, B; Pickl, WF; Schuch, K; Sperr, WR; Stefanzl, G; Valent, P; Willmann, M | 1 |
| Grandis, JR; Johnson, DE; Li, C; Yazbeck, VY; Zang, Y | 1 |
| Adams, JW; Berger, MS; Chiappori, A; Edelman, MJ; Haura, EB; Malik, S; Northfelt, DW; Rosen, P; Van Echo, DA; Williams, C | 1 |
| Armeanu-Ebinger, S; Ellerkamp, V; Fuchs, J; Lieber, J; Vogt, F; Warmann, SW; Wenz, J | 1 |
| Croft, A; Farrelly, ML; Hersey, P; Jiang, CC; Wroblewski, D; Zhang, XD | 1 |
| Donahue, RN; Farsaci, B; Grenga, I; Gulley, JL; Jochems, C; Kim, PS; Schlom, J; Tsang, KY | 1 |
| Chen, S; Ge, Y; Niu, X; Tan, W; Wang, G; Wang, H; Zhao, J; Zhao, L | 1 |
| Bejot, C; Berger, M; Feldman, T; Ford, P; Fung, HC; Goy, A; Mato, A | 1 |
| Berger, M; Ford, P; Goy, A; Hernandez-Ilzaliturri, FJ; Kahl, B; Protomastro, E | 1 |
| Higashihara, M; Horie, R; Umezawa, K; Watanabe, M | 1 |
| Gu, C; Li, X; Liu, S; Shi, L; Xun, T; Yu, L; Zhong, D | 1 |
| Bradshaw, TD; Coyle, B; Grundy, RG; Kerr, ID; Kimishi, I; Korshunov, A; Othman, RT; Pfister, SM; Storer, LC | 1 |
| Mishra, A; Singh, A; Verma, S | 1 |
| Albert, I; Ao-Baslock, A; Berger, MS; Blakely, LJ; Kazarnowicz, A; Kovacs, P; Langer, CJ; Moezi, MM; Pajkos, G; Pathak, AK; Ross, HJ; Schnyder, J; Schreeder, MT; Somfay, A; Zatloukal, P | 1 |
| Chen, S; Dai, Y; Grant, S; Jones, R; Leng, Y; Lin, H; Orlowski, RZ; Pei, XY; Zhang, Y; Zhou, L | 1 |
| Champa, D; Di Cristofano, A; Ghossein, RA; Liao, XH; Refetoff, S; Russo, MA | 1 |
| Anderson, MA; Huang, D; Roberts, A | 1 |
| Arellano, ML; Berger, M; Borthakur, G; Luer, J; Raza, A | 1 |
| Bharti, A; Chipuk, JE; Elkholi, R; Renault, TT | 1 |
| Behnam-Motlagh, P; Brenner, C; Castedo, M; Garcia, P; Kohno, K; Kroemer, G; Lissa, D; Michels, J; Obrist, F; Vitale, I; Wu, GS | 1 |
| Elssner, C; Jaeger, D; Kautz, N; Koehler, BC; Lorenz, S; Scherr, AL; Schulze-Bergkamen, H; Urbanik, T; Welte, S | 1 |
| Adamson, PC; Fox, E; Moorthy, GS; Norris, RE | 1 |
| Borthakur, G; Carter, TH; Claxton, D; DeAngelo, DJ; Erba, H; Goard, C; Raza, A; Schimmer, AD; Tallman, MS | 1 |
| Caldwell, JT; Edwards, H; Ge, Y; Taub, JW; Wang, G; Xie, C | 1 |
| Chen, S; Cui, L; Cui, X; Edwards, H; Ge, Y; Wang, G | 1 |
| Ghaisas, G; Kannan, S; Mallick, S; Palve, V; Teni, T | 1 |
| Liang, LZ; Liang, YJ; Liao, GQ; Liu, HC; Ma, B; Su, YX; Zhang, TH; Zheng, GS | 1 |
| Chang, JH; Chen, KF; Chen, PP; Huang, JW; Shiau, CW; Su, JC; Tseng, PH | 1 |
| Abdullahi, M; Arang, N; Austin, LS; Billman, ZP; Douglass, AN; Hume, JCC; Kain, HS; Kappe, SHI; Kaushansky, A; Mikolajczak, SA; Murphy, SC | 1 |
| Lee, JY; Lee, NK; No, JH; Oh, JH; Park, JH | 1 |
| Armeanu-Ebinger, S; Fuchs, J; Lieber, J | 1 |
| Bu, H; Culig, Z; Eder, IE; Egger, M; Erb, HH; Feiersinger, GE; Handle, F; Klocker, H; Luef, B; Maitland, NJ; Oh, SJ; Ploner, C; Rane, JK; Santer, FR; Schäfer, G | 1 |
| Brown, JR; Fisher, DC; Freedman, AS; Mikler, E; Neuberg, D; Reynolds, HM; Takebe, N; Tesar, B; Thompson, C; Werner, L; Yu, L | 1 |
| Bonzi, MC; Craparotta, I; Gariboldi, MB; Giovannardi, S; Mancini, M; Monti, E; Taiana, E | 1 |
| Antoine, R; Aronssohn, N; Drink, E; Dugourd, P; Dumont, E; Loison, C | 1 |
| Abusneina, A; Clément, J; Gauthier, ER; Harnett, CC | 1 |
| Becher-Boveleth, N; Broecker-Preuss, M; Fuhrer, D; Jastrow, H; Mann, K; Viehof, J | 1 |
| Bernier, C; Cencic, R; Ertel, F; Nguyen, M; Pelletier, J; Roulston, A; Shore, GC; Silvius, JR | 1 |
| Allendorf, D; Jassowicz, A; Köhler, BC; Theile, D; Weiss, J | 1 |
| Elssner, C; Jaeger, D; Jassowicz, A; Kautz, N; Koehler, BC; Lorenz, S; Radhakrishnan, P; Scherr, AL; Schneider, M; Schulze-Bergkamen, H; Weiss, J | 1 |
| Cerchietti, L; Dupont, T; Hatzi, K; Leonard, J; Malik, A; Martin, P; Melnick, A; Patel, J; Tam, W; Yang, SN | 1 |
| Anastasina, M; Bamford, DH; De Brabander, JK; Islam, MM; Julkunen, I; Kainov, D; Matikainen, S; Nyman, TA; Poranen, MM; Saelens, X; Šaulienė, I; Söderholm, S; Stenman, J; Tynell, J | 1 |
| Becher-Boveleth, N; Broecker-Preuss, M; Mann, K | 1 |
| Mazur, L; Opydo-Chanek, M | 1 |
| Chan, MT; Gu, C; Kong, Y; Lin, Q; Liu, S; Wu, WK; Yu, L; Zhao, X; Zhong, D; Zhou, Z | 1 |
| Bamrah, H; Farrell, WE; Fisher, N; Price, JC; Redman, CW; Richardson, A; Stamelos, VA; Voisey, C | 1 |
| Gu, CP; Lin, QH; Liu, SW; Que, FC; Yu, L; Zhao, XY | 1 |
| Liu, K; Ma, J; Wu, K; Xu, Z; Zhao, Z | 1 |
| Champa, D; Cuervo, AM; Di Cristofano, A; Orlacchio, A; Patel, B; Ranieri, M; Shemetov, AA; Verkhusha, VV | 1 |
| Basu, S; Mallick, A; More, P; Syed, MM | 1 |
| He, G; Huang, Y; Li, X; Luo, Y; Shen, P; Wu, F; Yang, L; Zhang, N; Zhao, Y | 1 |
| Bi, L; Gomez, M; Haug, J; Kimlinger, T; Kumar, S; Mukhopadhyay, B; Painuly, U; Prasad, V; Rajkumar, SV; Ramakrishnan, V | 1 |
| Ghanem, G; Krayem, M; Ondrušová, L; Réda, J; Vachtenheim, J; Vlčková, K | 1 |
| Bamford, DH; Bugai, A; De Brabander, J; Fu, Y; Gaelings, L; Hukkanen, V; Julkunen, I; Kainov, DE; Kuisma, M; Le Goffic, R; Lorey, MB; Marjomäki, V; Matikainen, S; Miller, MS; Nandania, J; Nyman, TA; Paavilainen, H; Saelens, X; Schepens, B; Söderholm, S; Tynell, J; Vande Ginste, L; Velagapudi, V | 1 |
| Ahola, T; Hakanen, M; Kümmerer, BM; Merits, A; Rausalu, K; Saul, S; Susi, P; Varghese, FS | 1 |
| Chang, CC; Chang, Y; Cheung, MW; Ho, C; Huang, CP; Lee, WC; Lin, WC; Or, CR; Su, HL | 1 |
| Bespalov, MM; De Brabander, JK; Ianevski, A; Kainov, DE; Kuivanen, S; Nandania, J; Vapalahti, O; Velagapudi, V | 1 |
| Carroll, SL; Gibson, LM; Graham, CD; Kaza, N; Klocke, BJ; Pruitt, HC; Roth, KA; Shevde, LA | 1 |
| Davids, MS; Lampson, BL | 1 |
| Calvo-Vidal, MN; Cayrol, F; Cerchietti, L; Cremaschi, G; Crescenzo, R; Fernando, TM; Gaudiano, M; Gray, NS; Inghirami, G; Kwiatkowski, N; Marullo, R; Pera, B; Phillip, J; Praditsuktavorn, P; Roman, L; Ruan, J; Takpradit, K; Yang, SN; Zhang, T | 1 |
| Luo, QY; Qiu, ZL; Shen, CT; Song, HJ; Sun, ZK; Wei, WJ; Zhang, XY | 1 |
| Berger, W; Heffeter, P; Keppler, BK; Kubista, B; Mayr, L; Schoefl, T; van Schoonhoven, S; Windhager, R | 1 |
| Altieri, DC; Banu, M; Bianchetti, E; Bruce, JN; Canoll, P; Horst, B; Ishida, CT; Karpel-Massler, G; Perez-Lorenzo, R; Roth, KA; Shu, C; Siegelin, MD | 1 |
| Cook, SJ; Gilley, R; Sale, MJ; Stuart, K | 1 |
| Agah, M; Clarke, R; Kikkeri, K; Shajahan-Haq, AN; Soltanian-Zadeh, S; Strobl, J | 1 |
| Byun, S; Lee, E; Lee, KW | 1 |
| Abu Bakar, MH; Mohamad Rosdi, MN; Mohamed Zulkifli, R; Mohd Arif, S; Razali, SA; Ya'akob, H | 1 |
| Hou, XF; Li, K; Li, S; Wang, JF; Wu, C; Xu, SN | 1 |
| Azad, N; Iyer, AKV; Kaushik, V; Way, LF; Yakisich, JS | 1 |
| Barrett, JS; Borden, KLB; Carroll, AJ; Carroll, MP; Chen, IL; Culjkovic-Kraljacic, B; Davenport, JW; Devidas, M; Dreyer, ZE; Felix, CA; Harvey, RC; Heerema, NA; Hilden, JM; Hunger, SP; Jin, S; Moore, JS; Porazzi, P; Robinson, BW; Seif, AE; Tasian, SK; Teachey, DT; Urtishak, KA; Vincent, TL; Wang, LS; Willman, CL | 1 |
| Ghosh, PM; Sam, A; Steele, TM; Talbott, GC; Tepper, CG; Vinall, RL | 1 |
| Dai, L; Li, Y; Liu, S; Liu, X; Luo, X; Que, F; Xu, Y; Yu, L; Zhou, D; Zhu, Y | 1 |
| Andersen, PI; Anthonsen, MW; Bjoras, M; Evander, M; Hukkanen, V; Ianevski, A; Jo, E; Kainov, DE; Koit, S; Krpina, K; Shtaida, N; Tenson, T; Windisch, MP; Yang, J; Zusinaite, E | 1 |
| Addioui, A; Beaunoyer, M; Belounis, A; Cournoyer, S; Haddad, E; Le Gall, R; Nyalendo, C; Sartelet, H; Teira, P; Vassal, G | 1 |
| Chang, CC; Chen, YJ; Huang, CW; Lai, YC; Or, CR | 1 |
| Caffrey, CR; Company, AH; Debnath, A; DeRisi, J; Ehrenkaufer, G; Gisselberg, J; Huston, CD; Kangussu-Marcolino, MM; Li, P; Monti, L; Moser, MS; Singh, U; Stebbins, EE; Wang, B; Wang, SC; White, CV; Yeh, E | 1 |
| Ballav, N; Basu, S; Pandey, S; Patil, S | 1 |
| Cichoń, I; Kołaczkowska, E; Mazur, L; Opydo-Chanek, M; Rak, A | 1 |
| Aas, PA; Afset, JE; Biza, S; Bjørås, M; Erlandsen, SE; Fenstad, MH; Hagen, L; Ianevski, A; Kainov, DE; Landsem, VM; Lysvand, H; Løseth, K; Malmring, JF; Nordbø, SA; Oksenych, V; Pettersen, CH; Reisberg, T; Tenson, T; Yao, R; Zusinaite, E | 1 |
| Chen, S; Duan, P; Ren, Y | 1 |
| Deng, K; Ding, C; Hong, B; Li, H; Lin, WC; Liu, XL; Lui, VWY; Lv, XT; Shi, WH; Yin, YP | 1 |
| de Jonge, MI; den Hartog, G; Eleveld, MJ; Kurver, L; Miesen, P; Overheul, GJ; van Heerbeek, N; van Laarhoven, A; van Rij, RP; van Woudenbergh, E; Varghese, FS | 1 |
| Cai, X; Deng, Y; Hu, J; Hu, Y; Huang, A; Katschinski, B; Le-Trilling, VTK; Lin, Y; Lu, M; Mao, B; Mennerich, D; Tang, N; Trilling, M; Wang, J; Wang, K; Xu, S; Zhang, G; Zhao, Z; Zheng, J | 1 |
| Alt, J; Eberhart, CG; Figg, WD; Findlay, TR; Kaur, H; Malebranche, KJ; Maxwell, MJ; Odabas, A; Parkhurst, A; Peer, CJ; Raabe, EH; Rubens, JA; Slusher, BS; Wang, SZ; Warren, KE | 1 |
| Cui, X; Jia, F; Li, Y; Pan, Z; Wang, X; Wu, Y | 1 |
19 review(s) available for pyrroles and gx 15-070
| Article | Year |
|---|---|
Non-peptidic small molecule inhibitors against Bcl-2 for cancer therapy.
Topics: Aniline Compounds; Animals; Apoptosis; Benzamides; Binding Sites; Biphenyl Compounds; Gossypol; Humans; Indoles; Lymphoma; Models, Molecular; Neoplasms; Nitrophenols; Piperazines; Protein Structure, Tertiary; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Sulfonamides; Sulfones | 2009 |
Novel agents in chronic lymphocytic leukemia: efficacy and tolerability of new therapies.
Topics: Antineoplastic Agents; Bendamustine Hydrochloride; Flavonoids; Humans; Indoles; Lenalidomide; Leukemia, Lymphocytic, Chronic, B-Cell; Maximum Tolerated Dose; Nitrogen Mustard Compounds; Piperidines; Pyrroles; Thalidomide; Thionucleotides; Treatment Outcome | 2008 |
Bcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy.
Topics: Aniline Compounds; Animals; Antineoplastic Agents; Apoptosis; Biphenyl Compounds; Gossypol; Humans; Indoles; Mitochondria; Neoplasms; Nitrophenols; Piperazines; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Sulfonamides; Thionucleotides | 2009 |
Mimicking the BH3 domain to kill cancer cells.
Topics: Aniline Compounds; Animals; Antineoplastic Agents; Apoptosis; Benzamides; Binding, Competitive; Biphenyl Compounds; Clinical Trials as Topic; Dimerization; Drug Delivery Systems; Drug Design; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Indoles; Mice; Mitochondria; Multigene Family; Neoplasm Proteins; Neoplasms; Nitrophenols; Piperazines; Protein Structure, Tertiary; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Structure-Activity Relationship; Sulfonamides; Sulfones; Thionucleotides | 2008 |
BH3-only proteins in rheumatoid arthritis: potential targets for therapeutic intervention.
Topics: Animals; Antirheumatic Agents; Apoptosis; Apoptosis Regulatory Proteins; Arthritis, Rheumatoid; Autoimmunity; Bcl-2-Like Protein 11; BH3 Interacting Domain Death Agonist Protein; Drug Delivery Systems; Drug Design; Gene Expression Regulation; Humans; Indoles; Macrophages; Membrane Proteins; Mice; Mice, Inbred C57BL; Protein Structure, Tertiary; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Structure-Activity Relationship; T-Lymphocyte Subsets | 2008 |
New insights on the antitumoral properties of prodiginines.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; DNA Damage; Humans; Indoles; Neoplasms; Prodigiosin; Pyrroles; Serratia; Signal Transduction | 2010 |
Targeting mitochondria for cancer therapy.
Topics: Animals; Antineoplastic Agents; Cell Membrane Permeability; HSP90 Heat-Shock Proteins; Humans; Indoles; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Pyrroles; Reactive Oxygen Species; Resveratrol; Stilbenes | 2010 |
Drugs targeting Bcl-2 family members as an emerging strategy in cancer.
Topics: Aniline Compounds; Antineoplastic Agents; Drug Delivery Systems; Humans; Indoles; Neoplasms; Protein Binding; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Sulfonamides | 2010 |
Overcoming blocks in apoptosis with BH3-mimetic therapy in haematological malignancies.
Topics: Aniline Compounds; Antineoplastic Agents; Apoptosis; Biphenyl Compounds; Hematologic Neoplasms; Humans; Indoles; Molecular Mimicry; Nitrophenols; Piperazines; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Sulfonamides | 2011 |
Obatoclax mesylate : pharmacology and potential for therapy of hematological neoplasms.
Topics: Antineoplastic Agents; Apoptosis; Clinical Trials as Topic; Drug Delivery Systems; Drug Resistance, Neoplasm; Humans; Indoles; Leukemia; Lymphoma; Proto-Oncogene Proteins c-bcl-2; Pyrroles | 2012 |
Bcl-2 inhibitors: emerging drugs in cancer therapy.
Topics: Antineoplastic Agents; Apoptosis; Clinical Trials as Topic; Gossypol; Humans; Indoles; Models, Biological; Molecular Mimicry; Neoplasms; Proto-Oncogene Proteins c-bcl-2; Pyrroles | 2012 |
Targeting the B-cell lymphoma/leukemia 2 family in cancer.
Topics: Aniline Compounds; Animals; Antineoplastic Agents; Apoptosis; Biphenyl Compounds; Drug Resistance, Neoplasm; Humans; Indoles; Molecular Targeted Therapy; Neoplasms; Nitrophenols; Piperazines; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Sulfonamides; Thionucleotides; Treatment Outcome | 2012 |
BH3 mimetics: status of the field and new developments.
Topics: Amino Acid Motifs; Aniline Compounds; Antineoplastic Agents; Apoptosis; Bridged Bicyclo Compounds, Heterocyclic; Clinical Trials as Topic; Drug Design; Drug Screening Assays, Antitumor; Gossypol; Humans; Indoles; Molecular Mimicry; Neoplasms; Peptide Fragments; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Sulfonamides | 2013 |
Autophagy contributes to modulating the cytotoxicities of Bcl-2 homology domain-3 mimetics.
Topics: Aniline Compounds; Animals; Antineoplastic Agents; Apoptosis; Autophagy; Gastrointestinal Neoplasms; Humans; Indoles; Molecular Mimicry; Protein Interaction Domains and Motifs; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Sulfonamides | 2013 |
Targeting BCL2 for the treatment of lymphoid malignancies.
Topics: Aniline Compounds; Antineoplastic Agents; Bridged Bicyclo Compounds, Heterocyclic; Gossypol; Hematologic Neoplasms; Humans; Indoles; Leukemia, Lymphocytic, Chronic, B-Cell; Peptide Fragments; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Sulfonamides | 2014 |
The role of BH3-mimetic drugs in the treatment of pediatric hepatoblastoma.
Topics: Antibodies, Monoclonal; Apoptosis; Biphenyl Compounds; Child; Drug Resistance, Neoplasm; Hepatoblastoma; Humans; Indoles; Liver Neoplasms; Nitrophenols; Piperazines; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Sulfonamides; TNF-Related Apoptosis-Inducing Ligand | 2015 |
The Development and Current Use of BCL-2 Inhibitors for the Treatment of Chronic Lymphocytic Leukemia.
Topics: Aniline Compounds; Antineoplastic Agents; Bridged Bicyclo Compounds, Heterocyclic; Gossypol; Humans; Indoles; Leukemia, Lymphocytic, Chronic, B-Cell; Neutropenia; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Sulfonamides; Thionucleotides | 2017 |
Control of cell death and mitochondrial fission by ERK1/2 MAP kinase signalling.
Topics: Aniline Compounds; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Regulatory Proteins; Bridged Bicyclo Compounds, Heterocyclic; Drug Screening Assays, Antitumor; Humans; Indoles; MAP Kinase Signaling System; Mitochondrial Dynamics; Molecular Targeted Therapy; Neoplasm Proteins; Neoplasms; Oncogene Addiction; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Sulfonamides | 2017 |
Therapeutic Implications of Autophagy Inducers in Immunological Disorders, Infection, and Cancer.
Topics: Adaptive Immunity; Animals; Autoimmune Diseases; Autophagy; Benzylisoquinolines; Cholecalciferol; Humans; Immune System Diseases; Immunity, Innate; Indoles; Infections; Isoquinolines; Lysosomes; Maprotiline; Metformin; Neoplasms; Phenols; Pyrroles; Resveratrol; Sirolimus; Spermidine; Stilbenes; Tetrahydroisoquinolines; Trehalose | 2017 |
15 trial(s) available for pyrroles and gx 15-070
| Article | Year |
|---|---|
Phase I study of obatoclax mesylate (GX15-070), a small molecule pan-Bcl-2 family antagonist, in patients with advanced chronic lymphocytic leukemia.
Topics: Aged; Anemia; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Female; Humans; Indoles; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphocyte Count; Male; Maximum Tolerated Dose; Middle Aged; Platelet Count; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Thrombocytosis | 2009 |
A phase I study of the pan bcl-2 family inhibitor obatoclax mesylate in patients with advanced hematologic malignancies.
Topics: Adult; Aged; Aged, 80 and over; Electrocardiography; Female; Humans; Indoles; Leukemia; Male; Middle Aged; Proto-Oncogene Proteins c-bcl-2; Pyrroles | 2008 |
A phase I study of obatoclax mesylate, a Bcl-2 antagonist, plus topotecan in solid tumor malignancies.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Small Cell; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Indoles; Lung Neoplasms; Male; Maximum Tolerated Dose; Mesylates; Middle Aged; Patient Selection; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Recurrence; Topotecan | 2010 |
Phase I dose finding studies of obatoclax (GX15-070), a small molecule pan-BCL-2 family antagonist, in patients with advanced solid tumors or lymphoma.
Topics: Adult; Aged; Antineoplastic Agents; Area Under Curve; Dose-Response Relationship, Drug; Female; Humans; Indoles; Lymphoma; Male; Maximum Tolerated Dose; Middle Aged; Neoplasms; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Remission Induction | 2010 |
Phase II study of obatoclax mesylate (GX15-070), a small-molecule BCL-2 family antagonist, for patients with myelofibrosis.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Female; Humans; Indoles; Male; Middle Aged; Primary Myelofibrosis; Proto-Oncogene Proteins c-bcl-2; Pyrroles | 2010 |
A phase II study of obatoclax mesylate, a Bcl-2 antagonist, plus topotecan in relapsed small cell lung cancer.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cell; Disease Progression; Female; Humans; Indoles; Lung Neoplasms; Middle Aged; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Recurrence; Thrombocytopenia; Topotecan | 2011 |
A phase I trial of pan-Bcl-2 antagonist obatoclax administered as a 3-h or a 24-h infusion in combination with carboplatin and etoposide in patients with extensive-stage small cell lung cancer.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Central Nervous System; Drug Administration Schedule; Etoposide; Female; Humans; Indoles; Lung Neoplasms; Male; Maximum Tolerated Dose; Middle Aged; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Small Cell Lung Carcinoma | 2012 |
Experience with obatoclax mesylate (GX15-070), a small molecule pan-Bcl-2 family antagonist in patients with relapsed or refractory classical Hodgkin lymphoma.
Topics: Adult; Antineoplastic Agents; Female; Hematopoietic Stem Cell Transplantation; Hodgkin Disease; Humans; Indoles; Male; Middle Aged; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Recurrence; Treatment Outcome | 2012 |
Potent obatoclax cytotoxicity and activation of triple death mode killing across infant acute lymphoblastic leukemia.
Topics: Antineoplastic Agents; Apoptosis; Autophagy; Cell Line, Tumor; Drug Resistance, Neoplasm; Gene Expression Regulation, Leukemic; Histone-Lysine N-Methyltransferase; Humans; Indoles; Infant; Infant, Newborn; Myeloid-Lymphoid Leukemia Protein; Necrosis; Oncogene Proteins, Fusion; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proto-Oncogene Proteins c-bcl-2; Pyrroles | 2013 |
Obatoclax mesylate, a pan-bcl-2 inhibitor, in combination with docetaxel in a phase 1/2 trial in relapsed non-small-cell lung cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Docetaxel; Humans; Indoles; Lung Neoplasms; Maximum Tolerated Dose; Neoplasm Recurrence, Local; Pyrroles; Taxoids | 2014 |
A phase I/II study of the pan Bcl-2 inhibitor obatoclax mesylate plus bortezomib for relapsed or refractory mantle cell lymphoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Combined Modality Therapy; Disease Progression; Female; Humans; Indoles; Lymphoma, Mantle-Cell; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Pyrroles; Treatment Outcome | 2014 |
Randomized phase II study of carboplatin and etoposide with or without obatoclax mesylate in extensive-stage small cell lung cancer.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Comorbidity; Etoposide; Female; Humans; Indoles; Lung Neoplasms; Male; Middle Aged; Neoplasm Metastasis; Neoplasm Staging; Pyrroles; Small Cell Lung Carcinoma; Treatment Outcome | 2014 |
A phase II, multicenter, open-label study of obatoclax mesylate in patients with previously untreated myelodysplastic syndromes with anemia or thrombocytopenia.
Topics: Aged; Aged, 80 and over; Anemia; Antineoplastic Agents; Disease Progression; Female; Humans; Indoles; Male; Middle Aged; Myelodysplastic Syndromes; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Thrombocytopenia; Treatment Outcome | 2014 |
A multicenter phase I/II study of obatoclax mesylate administered as a 3- or 24-hour infusion in older patients with previously untreated acute myeloid leukemia.
Topics: Aged; Aged, 80 and over; Blast Crisis; Demography; Drug Administration Schedule; Female; Humans; Indoles; Leukemia, Myeloid, Acute; Male; Neutrophils; Platelet Count; Pyrroles; Treatment Outcome | 2014 |
Obatoclax in combination with fludarabine and rituximab is well-tolerated and shows promising clinical activity in relapsed chronic lymphocytic leukemia.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biomarkers; Chromosome Aberrations; Combined Modality Therapy; Disease Progression; Female; Humans; Indoles; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Mutation; Neoplasm Staging; Pyrroles; Recurrence; Retreatment; Rituximab; Treatment Outcome; Vidarabine | 2015 |
139 other study(ies) available for pyrroles and gx 15-070
| Article | Year |
|---|---|
Modulating the bcl-2 family of apoptosis suppressors for potential therapeutic benefit in cancer.
Topics: Animals; Apoptosis; Biphenyl Compounds; Cell Line, Tumor; Cell Survival; Genes, myc; Humans; Indoles; Models, Animal; Neoplasms; Nitrophenols; Oncogenes; Piperazines; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-myc; Pyrroles; Sulfonamides | 2005 |
Bcl-2 inhibitors induce apoptosis in chronic lymphocytic leukemia cells.
Topics: Antimycin A; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzopyrans; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Drug Synergism; Humans; Indoles; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Mantle-Cell; Nitriles; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Splenic Neoplasms | 2006 |
Synergistic inhibition of breast cancer cell lines with a dual inhibitor of EGFR-HER-2/neu and a Bcl-2 inhibitor.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Benzopyrans; Breast Neoplasms; Cell Line, Tumor; Drug Design; Drug Screening Assays, Antitumor; Drug Synergism; ErbB Receptors; Humans; Indoles; Lapatinib; Nitriles; Prognosis; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Quinazolines; Receptor, ErbB-2 | 2007 |
The BH3-mimetic GX15-070 synergizes with bortezomib in mantle cell lymphoma by enhancing Noxa-mediated activation of Bak.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-X Protein; Boronic Acids; Bortezomib; Drug Synergism; Gene Expression Regulation, Neoplastic; Humans; Indoles; Lymphoma, Mantle-Cell; Molecular Mimicry; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Peptide Fragments; Protein Binding; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Pyrroles; Tumor Cells, Cultured | 2007 |
Preclinical studies of the pan-Bcl inhibitor obatoclax (GX015-070) in multiple myeloma.
Topics: Apoptosis Regulatory Proteins; bcl-2 Homologous Antagonist-Killer Protein; Bcl-2-Like Protein 11; Caspase 3; Cell Line, Tumor; Cytochromes c; Drug Screening Assays, Antitumor; Humans; Indoles; Membrane Proteins; Multiple Myeloma; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Protein Binding; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Up-Regulation | 2007 |
A small molecule pan-Bcl-2 family inhibitor, GX15-070, induces apoptosis and enhances cisplatin-induced apoptosis in non-small cell lung cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Survival; Cisplatin; Dose-Response Relationship, Drug; Drug Synergism; ErbB Receptors; Humans; Immunoprecipitation; Indoles; Lung Neoplasms; Neoplasm Proteins; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Tetrazolium Salts; Thiazoles | 2008 |
Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis.
Topics: Animals; Antineoplastic Agents; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; Boronic Acids; Bortezomib; Cell Line, Tumor; Cysteine Proteinase Inhibitors; Drug Resistance, Neoplasm; Humans; Indoles; Melanoma; Mice; Mitochondria; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Proteasome Inhibitors; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Pyrroles | 2007 |
Targeting 14-3-3 sensitizes native and mutant BCR-ABL to inhibition with U0126, rapamycin and Bcl-2 inhibitor GX15-070.
Topics: 14-3-3 Proteins; Amino Acid Sequence; Antineoplastic Agents; Apoptosis; Benzamides; Butadienes; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Forkhead Box Protein O3; Forkhead Transcription Factors; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Indoles; Intracellular Signaling Peptides and Proteins; K562 Cells; Molecular Sequence Data; Mutation, Missense; Neoplasm Proteins; Nitriles; Peptides; Piperazines; Point Mutation; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Recombinant Fusion Proteins; Signal Transduction; Sirolimus | 2008 |
Molecule of the month. Elesclomol and obatoclax mesylate.
Topics: Antineoplastic Agents; Controlled Clinical Trials as Topic; Humans; Hydrazines; Indoles; Melanoma; Neoplasm Metastasis; Neoplasms; Pyrroles | 2008 |
Mechanisms of antileukemic activity of the novel Bcl-2 homology domain-3 mimetic GX15-070 (obatoclax).
Topics: Animals; Antineoplastic Agents; Apoptosis; AraC Transcription Factor; Biomimetics; Biphenyl Compounds; Cells, Cultured; Drug Synergism; HL-60 Cells; Humans; Indoles; Leukemia; Mice; Mice, Knockout; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Nitrophenols; Piperazines; Protein Structure, Tertiary; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Sulfonamides; Tumor Stem Cell Assay; U937 Cells | 2008 |
BCL-2 phosphorylation modulates sensitivity to the BH3 mimetic GX15-070 (Obatoclax) and reduces its synergistic interaction with bortezomib in chronic lymphocytic leukemia cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Boronic Acids; Bortezomib; Drug Synergism; Humans; Indoles; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Mantle-Cell; Mitochondria; Phosphorylation; Protease Inhibitors; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Pyrroles; Tumor Cells, Cultured | 2008 |
Bcl-2 family members as molecular targets in cancer therapy.
Topics: Antineoplastic Agents; Apoptosis; Benzopyrans; BH3 Interacting Domain Death Agonist Protein; Biological Products; Genes, bcl-2; Gossypol; Humans; Indoles; Neoplasms; Nitriles; Oligonucleotides, Antisense; Proto-Oncogene Proteins c-bcl-2; Pyrroles | 2008 |
BH3-only protein mimetic obatoclax sensitizes cholangiocarcinoma cells to Apo2L/TRAIL-induced apoptosis.
Topics: Apoptosis; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cell Line, Tumor; Cholangiocarcinoma; Fluorescent Antibody Technique; Humans; Indoles; Molecular Mimicry; Pyrroles; TNF-Related Apoptosis-Inducing Ligand | 2008 |
BH3 mimetic obatoclax enhances TRAIL-mediated apoptosis in human pancreatic cancer cells.
Topics: Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; BH3 Interacting Domain Death Agonist Protein; Caspases; Cell Line, Tumor; Cytochromes c; Humans; Indoles; Myeloid Cell Leukemia Sequence 1 Protein; Pancreatic Neoplasms; Proto-Oncogene Proteins c-bcl-2; Pyrroles; TNF-Related Apoptosis-Inducing Ligand | 2009 |
Human melanoma cells under endoplasmic reticulum stress are more susceptible to apoptosis induced by the BH3 mimetic obatoclax.
Topics: Antiviral Agents; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; Blotting, Western; Endoplasmic Reticulum; Enzyme Inhibitors; Humans; Immunoprecipitation; Indoles; Melanoma; Membrane Potential, Mitochondrial; Myeloid Cell Leukemia Sequence 1 Protein; Oxidative Stress; Peptide Fragments; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Pyrroles; RNA, Small Interfering; Thapsigargin; Tumor Cells, Cultured; Tunicamycin | 2009 |
Inhibition of MCL-1 enhances lapatinib toxicity and overcomes lapatinib resistance via BAK-dependent autophagy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Autophagy; bcl-2 Homologous Antagonist-Killer Protein; Cell Death; Drug Resistance, Neoplasm; Drug Synergism; Enzyme Activation; HCT116 Cells; Humans; Indoles; Lapatinib; Mutation; Myeloid Cell Leukemia Sequence 1 Protein; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Quinazolines | 2009 |
Autophagy can contribute to cell death when combining targeted therapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Autophagy; Cell Death; Colonic Neoplasms; HCT116 Cells; Humans; Indoles; Lapatinib; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Quinazolines | 2009 |
The BH3-mimetic GX15-070 induces autophagy, potentiates the cytotoxicity of carboplatin and 5-fluorouracil in esophageal carcinoma cells.
Topics: Autophagy; Carboplatin; Cell Line, Tumor; Cell Proliferation; Drug Synergism; Drug Therapy, Combination; Esophageal Neoplasms; Fluorouracil; Humans; Indoles; Osteosarcoma; Pyrroles; Signal Transduction | 2010 |
A Bax-mediated mechanism for obatoclax-induced apoptosis of cholangiocarcinoma cells.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Cell Line, Tumor; Cholangiocarcinoma; Humans; Indoles; Male; Mitochondria; Pyrroles; Rats; Rats, Inbred F344 | 2010 |
Induction of autophagy-dependent necroptosis is required for childhood acute lymphoblastic leukemia cells to overcome glucocorticoid resistance.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Dexamethasone; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Glucocorticoids; Humans; Indoles; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Myeloid Cell Leukemia Sequence 1 Protein; Nuclear Pore Complex Proteins; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-bcl-2; Pyrroles; RNA-Binding Proteins; TOR Serine-Threonine Kinases; Xenograft Model Antitumor Assays | 2010 |
The human stem cell hierarchy is defined by a functional dependence on Mcl-1 for self-renewal capacity.
Topics: Animals; beta 2-Microglobulin; Blotting, Western; Bone Marrow Cells; Cell Differentiation; Cell Proliferation; Cells, Cultured; Female; Fetal Blood; Flow Cytometry; Hematopoiesis; Hematopoietic Stem Cells; Humans; Indoles; Male; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Mice, SCID; Myeloid Cell Leukemia Sequence 1 Protein; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2010 |
The combination of a histone deacetylase inhibitor with the Bcl-2 homology domain-3 mimetic GX15-070 has synergistic antileukemia activity by activating both apoptosis and autophagy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Benzamides; Cell Line, Tumor; Cell Proliferation; Drug Synergism; Histone Deacetylase Inhibitors; HL-60 Cells; Humans; Hydroxamic Acids; Indoles; Leukemia; Microscopy, Electron, Transmission; Proto-Oncogene Proteins c-bcl-2; Pyrimidines; Pyrroles; Reverse Transcriptase Polymerase Chain Reaction; Vorinostat | 2010 |
The combination of a histone deacetylase inhibitor with the BH3-mimetic GX15-070 has synergistic antileukemia activity by activating both apoptosis and autophagy.
Topics: Apoptosis; Autophagy; Benzamides; BH3 Interacting Domain Death Agonist Protein; Cell Line, Tumor; Drug Synergism; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Indoles; Leukemia, Myeloid, Acute; Pyrimidines; Pyrroles; Vorinostat | 2010 |
VSV oncolysis in combination with the BCL-2 inhibitor obatoclax overcomes apoptosis resistance in chronic lymphocytic leukemia.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Combined Modality Therapy; Disease Models, Animal; Female; Genetic Therapy; Humans; Indoles; Leukemia, Lymphocytic, Chronic, B-Cell; Mice; Mice, SCID; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Reverse Transcriptase Polymerase Chain Reaction; Vesiculovirus | 2010 |
Inhibition of MCL-1 in breast cancer cells promotes cell death in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Blotting, Western; Breast Neoplasms; Cell Death; Cell Line, Tumor; Cyclin-Dependent Kinases; Drug Synergism; Electrophoresis, Polyacrylamide Gel; ErbB Receptors; Female; Flavonoids; Fluorescent Antibody Technique; Gene Knockout Techniques; Humans; Indoles; Lapatinib; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Molecular Targeted Therapy; Myeloid Cell Leukemia Sequence 1 Protein; Piperidines; Proto-Oncogene Proteins c-bcl-2; Purines; Pyrroles; Quinazolines; Roscovitine | 2010 |
Have chemosensitizing strategies for multidrug-resistant childhood acute lymphoblastic leukemia come of age?
Topics: Antineoplastic Agents; Clinical Trials, Phase I as Topic; Drug Evaluation, Preclinical; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Indoles; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrroles | 2010 |
Platinum resistant cancer cells conserve sensitivity to BH3 domains and obatoclax induced mitochondrial apoptosis.
Topics: Adenosine Triphosphate; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Blotting, Western; Cell Line, Tumor; Cell Survival; Cisplatin; DNA Damage; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Indoles; Mitochondria; Neoplasms; Peptides; Platinum; Protein Structure, Tertiary; Protein Transport; Pyrroles | 2011 |
GX15-070 (obatoclax) overcomes glucocorticoid resistance in acute lymphoblastic leukemia through induction of apoptosis and autophagy.
Topics: Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Protein 5; bcl-2 Homologous Antagonist-Killer Protein; Beclin-1; Cell Line, Tumor; Drug Resistance, Neoplasm; Glucocorticoids; Humans; Indoles; Membrane Proteins; Microtubule-Associated Proteins; Myeloid Cell Leukemia Sequence 1 Protein; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proto-Oncogene Proteins c-bcl-2; Pyrroles; RNA Interference; RNA, Small Interfering | 2010 |
Obatoclax induces Atg7-dependent autophagy independent of beclin-1 and BAX/BAK.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Protein 7; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Beclin-1; Cell Line, Tumor; Cell Membrane; Drug Resistance, Neoplasm; Humans; Indoles; Membrane Proteins; Mice; Myeloid Cell Leukemia Sequence 1 Protein; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Ubiquitin-Activating Enzymes | 2010 |
Optimization of circulating biomarkers of obatoclax-induced cell death in patients with small cell lung cancer.
Topics: Antineoplastic Agents; Biomarkers, Tumor; Blood Chemical Analysis; Calibration; Cell Death; Cell Line, Tumor; Cell Proliferation; Cisplatin; Clinical Trials, Phase I as Topic; Drug Synergism; Etoposide; Humans; Indoles; Lung Neoplasms; Prognosis; Pyrroles; Small Cell Lung Carcinoma | 2011 |
Distinct cellular and therapeutic effects of obatoclax in rituximab-sensitive and -resistant lymphomas.
Topics: Antibodies, Monoclonal, Murine-Derived; Antibody-Dependent Cell Cytotoxicity; Antineoplastic Combined Chemotherapy Protocols; Apoptosis Regulatory Proteins; Autophagy; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Caspases; Cell Death; Drug Evaluation, Preclinical; Drug Resistance, Neoplasm; Drug Synergism; Humans; Indoles; Lymphoma, B-Cell; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Neoplasm Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Rituximab; Tumor Cells, Cultured; Up-Regulation | 2011 |
Molecular dynamics study of small molecule inhibitors of the Bcl-2 family.
Topics: Alanine; Amino Acid Sequence; Biphenyl Compounds; Humans; Indoles; Molecular Conformation; Molecular Dynamics Simulation; Molecular Sequence Data; Nitrophenols; Piperazines; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Sequence Alignment; Sulfonamides; Thermodynamics | 2011 |
The histone deacetylase inhibitor entinostat (SNDX-275) induces apoptosis in Hodgkin lymphoma cells and synergizes with Bcl-2 family inhibitors.
Topics: Acetylation; Apoptosis; Apoptosis Regulatory Proteins; Benzamides; Biphenyl Compounds; Boronic Acids; Bortezomib; Cyclin-Dependent Kinase Inhibitor p21; Deoxycytidine; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Drug Synergism; Gemcitabine; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Histones; Hodgkin Disease; Humans; Indoles; Lymphoma, Non-Hodgkin; Neoplasm Proteins; Nitrophenols; Piperazines; Protein Processing, Post-Translational; Pyrazines; Pyridines; Pyrroles; Sulfonamides; Tumor Cells, Cultured; X-Linked Inhibitor of Apoptosis Protein | 2011 |
Mcl-1 and YY1 inhibition and induction of DR5 by the BH3-mimetic Obatoclax (GX15-070) contribute in the sensitization of B-NHL cells to TRAIL apoptosis.
Topics: Apoptosis; B-Lymphocytes; Cell Line; Drug Resistance, Neoplasm; Humans; Indoles; Myeloid Cell Leukemia Sequence 1 Protein; NF-kappa B; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Receptors, TNF-Related Apoptosis-Inducing Ligand; RNA Interference; RNA, Small Interfering; Signal Transduction; TNF-Related Apoptosis-Inducing Ligand; YY1 Transcription Factor | 2011 |
Apoptosis sensitizers enhance cytotoxicity in hepatoblastoma cells.
Topics: Apoptosis; Benzamides; Benzopyrans; Biphenyl Compounds; Blotting, Western; Cell Survival; Drug Resistance, Neoplasm; Enzyme Inhibitors; Hepatoblastoma; Humans; Indoles; Liver Neoplasms; Nitriles; Nitrophenols; Piperazines; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Sulfonamides; Sulfones; Tumor Cells, Cultured | 2012 |
Synthetic prodiginine obatoclax (GX15-070) and related analogues: anion binding, transmembrane transport, and cytotoxicity properties.
Topics: Animals; Anions; Antineoplastic Agents; Apoptosis; Biological Transport; Cattle; Cell Line, Tumor; Crystallography, X-Ray; Humans; Indoles; Ion Transport; Ionophores; Liposomes; Lung Neoplasms; Magnetic Resonance Spectroscopy; Prodigiosin; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Tumor Cells, Cultured | 2011 |
Identification of dual mTORC1 and mTORC2 inhibitors in melanoma cells: prodigiosin vs. obatoclax.
Topics: Anti-Bacterial Agents; Antineoplastic Agents; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Humans; Indoles; Insulin Receptor Substrate Proteins; Mechanistic Target of Rapamycin Complex 1; Melanoma; Multiprotein Complexes; Phosphatidylinositol 3-Kinases; Prodigiosin; Proteins; Proto-Oncogene Proteins c-akt; Pyrroles; Ribosomal Protein S6 Kinases, 70-kDa; TOR Serine-Threonine Kinases; Transcription Factors | 2012 |
Obatoclax and lapatinib interact to induce toxic autophagy through NOXA.
Topics: Antineoplastic Agents; Autophagy; Cell Death; Cell Line, Tumor; Genes, erbB-2; Humans; Indoles; Lapatinib; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Quinazolines | 2012 |
Gfi-1 inhibits proliferation and colony formation of p210BCR/ABL-expressing cells via transcriptional repression of STAT 5 and Mcl-1.
Topics: Biomarkers, Tumor; Blotting, Western; Cell Proliferation; Chromatin Immunoprecipitation; Colony-Forming Units Assay; DNA-Binding Proteins; Down-Regulation; Gene Expression Profiling; Humans; Immunoenzyme Techniques; Indoles; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Luciferases; Myeloid Cell Leukemia Sequence 1 Protein; Oligonucleotide Array Sequence Analysis; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; STAT5 Transcription Factor; Transcription Factors; Tumor Cells, Cultured | 2012 |
Lapatinib and obatoclax kill tumor cells through blockade of ERBB1/3/4 and through inhibition of BCL-XL and MCL-1.
Topics: Antineoplastic Agents; Autophagy; bcl-X Protein; Cell Line, Tumor; ErbB Receptors; Humans; Indoles; Lapatinib; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasms; Proto-Oncogene Proteins c-bcl-2; PTEN Phosphohydrolase; Pyrroles; Quinazolines; Receptor, ErbB-3; Receptor, ErbB-4 | 2012 |
Protein-protein interaction inhibitors get into the groove.
Topics: Animals; bcl-X Protein; Binding Sites; Drug Discovery; Humans; Indoles; Protein Binding; Protein Interaction Domains and Motifs; Pyrroles | 2012 |
Obatoclax interacts synergistically with the irreversible proteasome inhibitor carfilzomib in GC- and ABC-DLBCL cells in vitro and in vivo.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Regulatory Proteins; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Bcl-2-Like Protein 11; Cell Line, Tumor; Drug Synergism; Germinal Center; Histones; Humans; Indoles; Lymphoma, Large B-Cell, Diffuse; MAP Kinase Kinase 4; Membrane Proteins; Mice; Mice, Nude; Myeloid Cell Leukemia Sequence 1 Protein; Oligopeptides; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Binding; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Xenograft Model Antitumor Assays | 2012 |
Cotargeting signaling pathways driving survival and cell cycle circumvents resistance to Kit inhibitors in leukemia.
Topics: Adenylate Kinase; Animals; Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm; Female; Humans; Imidazoles; Indoles; Leukemia, Mast-Cell; Mice; Mice, Nude; Mice, Transgenic; Neoplasm Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Phosphotyrosine; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Proto-Oncogene Proteins c-kit; Pyrroles; Quinolines; RNA Interference; RNA, Small Interfering; Signal Transduction; STAT5 Transcription Factor; Tumor Stem Cell Assay | 2012 |
Inhibition of Bcl-2 antiapoptotic members by obatoclax potently enhances sorafenib-induced apoptosis in human myeloid leukemia cells through a Bim-dependent process.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Benzenesulfonates; Cells, Cultured; Drug Synergism; Female; HL-60 Cells; Humans; Indoles; Leukemia, Myeloid; Membrane Proteins; Mice; Mice, Nude; Niacinamide; Phenylurea Compounds; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Pyridines; Pyrroles; Sorafenib; U937 Cells; Up-Regulation; Xenograft Model Antitumor Assays | 2012 |
A novel obatoclax derivative, SC-2001, induces apoptosis in hepatocellular carcinoma cells through SHP-1-dependent STAT3 inactivation.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Humans; Indoles; Liver Neoplasms; Mice; Mice, Nude; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Pyrroles; STAT3 Transcription Factor | 2012 |
Development of Noxa-like BH3 mimetics for apoptosis-based therapeutic strategy in chronic lymphocytic leukemia.
Topics: Aniline Compounds; Apoptosis; Biomimetic Materials; Gossypol; Humans; Indoles; Leukemia, Lymphocytic, Chronic, B-Cell; Myeloid Cell Leukemia Sequence 1 Protein; Peptide Fragments; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Sulfonamides | 2012 |
Mcl-1 Phosphorylation defines ABT-737 resistance that can be overcome by increased NOXA expression in leukemic B cells.
Topics: Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Biphenyl Compounds; Cell Line, Tumor; Drug Resistance, Neoplasm; Gossypol; Humans; Indoles; Leukemia, B-Cell; Membrane Proteins; Myeloid Cell Leukemia Sequence 1 Protein; Nitrophenols; Phosphorylation; Piperazines; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Pyrroles; RNA Interference; RNA, Small Interfering; Sulfonamides | 2012 |
CDK inhibitors upregulate BH3-only proteins to sensitize human myeloma cells to BH3 mimetic therapies.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; bcl-X Protein; Biomimetic Materials; Cell Line, Tumor; Cyclin-Dependent Kinases; Drug Synergism; Flavonoids; Humans; Indoles; Membrane Proteins; Mice; Mice, Inbred NOD; Mice, Nude; Mice, SCID; Mitochondria; Multiple Myeloma; Myeloid Cell Leukemia Sequence 1 Protein; Peptide Fragments; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Up-Regulation; Xenograft Model Antitumor Assays | 2012 |
Copy number aberrations of BCL2 and CDKN2A/B identified by array-CGH in thymic epithelial tumors.
Topics: Adult; Aged; Aged, 80 and over; Algorithms; Aniline Compounds; Animals; Apoptosis Regulatory Proteins; Autophagy; bcl-X Protein; Benzenesulfonates; Cell Line, Tumor; Cell Proliferation; Comparative Genomic Hybridization; Cyclin-Dependent Kinase Inhibitor p15; Cyclin-Dependent Kinase Inhibitor p16; DNA Copy Number Variations; Female; Humans; Indoles; Male; Mice; Mice, Nude; Middle Aged; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasms, Glandular and Epithelial; Niacinamide; Phenylurea Compounds; Prognosis; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Pyridines; Pyrroles; RNA Interference; RNA, Small Interfering; Sorafenib; Sulfonamides; Thymus Neoplasms; TOR Serine-Threonine Kinases; Transplantation, Heterologous | 2012 |
Obatoclax, saliphenylhalamide, and gemcitabine inhibit influenza a virus infection.
Topics: Amides; Animals; Antiviral Agents; Chlorocebus aethiops; Deoxycytidine; Dogs; Gemcitabine; Humans; Indoles; Influenza A Virus, H3N2 Subtype; Influenza, Human; Myeloid Cell Leukemia Sequence 1 Protein; Proto-Oncogene Proteins c-bcl-2; Pyrroles; RNA, Viral; Salicylates; Vero Cells; Virus Replication | 2012 |
Synthesis and biological activity of obatoclax derivatives as novel and potent SHP-1 agonists.
Topics: Cells, Cultured; Humans; Indoles; Molecular Structure; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Pyrroles; Structure-Activity Relationship | 2012 |
Lapatinib and obatoclax kill breast cancer cells through reactive oxygen species-dependent endoplasmic reticulum stress.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Autophagy; Breast Neoplasms; Cell Line, Tumor; eIF-2 Kinase; Endoplasmic Reticulum Stress; Female; HSP70 Heat-Shock Proteins; Humans; Indoles; Lapatinib; Membrane Proteins; Mice; Mice, Nude; Mitochondria; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase 9; p38 Mitogen-Activated Protein Kinases; Pyrroles; Quinazolines; Reactive Oxygen Species | 2012 |
BCL-2 inhibition targets oxidative phosphorylation and selectively eradicates quiescent human leukemia stem cells.
Topics: Apoptosis; Humans; Indoles; Leukemia, Myeloid, Acute; Neoplastic Stem Cells; Oxidative Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Reactive Oxygen Species; Tumor Cells, Cultured | 2013 |
GX15-070 (obatoclax) induces apoptosis and inhibits cathepsin D- and L-mediated autophagosomal lysis in antiestrogen-resistant breast cancer cells.
Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Breast Neoplasms; Cathepsin D; Cathepsin L; Cell Line, Tumor; Drug Resistance, Neoplasm; Estrogen Antagonists; Female; Humans; Indoles; Lysosomes; Membrane Proteins; Mice; Microtubule-Associated Proteins; Phagosomes; Pyrroles; Sequestosome-1 Protein; Transplantation, Heterologous | 2013 |
BH3 mimetics reduce adhesion and migration of hepatoblastoma and hepatocellular carcinoma cells.
Topics: Actins; Antineoplastic Agents; Apoptosis; Biphenyl Compounds; Blotting, Western; Carcinoma, Hepatocellular; Caspase 3; Caspase 7; Caspase Inhibitors; cdc42 GTP-Binding Protein; Cell Adhesion; Cell Movement; Cytoskeleton; Enzyme Activation; Fluorescent Antibody Technique; Hepatoblastoma; Humans; Indoles; Neoplasm Metastasis; Nitrophenols; Oligopeptides; Piperazines; Proteolysis; Pseudopodia; Pyrroles; Sulfonamides | 2013 |
βArrestin-1 and Mcl-1 modulate self-renewal growth of cancer stem-like side-population cells in non-small cell lung cancer.
Topics: Animals; Arrestins; beta-Arrestins; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Humans; Indoles; Lung; Lung Neoplasms; Mice; Myeloid Cell Leukemia Sequence 1 Protein; Neoplastic Stem Cells; Proto-Oncogene Proteins c-bcl-2; Pyrroles | 2013 |
BH3-mimetics- and cisplatin-induced cell death proceeds through different pathways depending on the availability of death-related cellular components.
Topics: Animals; Apoptosis; Apoptotic Protease-Activating Factor 1; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Caspase 3; Cisplatin; Fibroblasts; HeLa Cells; Humans; Indoles; Mice; Mice, Knockout; Molecular Mimicry; Protein Interaction Domains and Motifs; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Signal Transduction | 2013 |
Microarray determination of Bcl-2 family protein inhibition sensitivity in breast cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Drug Screening Assays, Antitumor; Gamma Rays; Humans; Indoles; Microarray Analysis; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Reverse Transcriptase Polymerase Chain Reaction | 2013 |
Concurrent inhibition of PI3K and mTORC1/mTORC2 overcomes resistance to rapamycin induced apoptosis by down-regulation of Mcl-1 in mantle cell lymphoma.
Topics: Amino Acid Chloromethyl Ketones; Antibiotics, Antineoplastic; Apoptosis; bcl-X Protein; Caspase Inhibitors; Caspases; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclin D1; Down-Regulation; Drug Resistance, Neoplasm; Humans; Imidazoles; Indoles; Lymphoma, Mantle-Cell; Mechanistic Target of Rapamycin Complex 1; Mechanistic Target of Rapamycin Complex 2; Multiprotein Complexes; Myeloid Cell Leukemia Sequence 1 Protein; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Quinolines; RNA Interference; RNA, Small Interfering; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2013 |
BCL-2 inhibitors sensitize therapy-resistant chronic lymphocytic leukemia cells to VSV oncolysis.
Topics: Animals; Biphenyl Compounds; Blotting, Western; Cell Line, Tumor; Cell Survival; Cells, Cultured; Flow Cytometry; Fluorescent Antibody Technique; Humans; Immunoprecipitation; Indoles; Leukemia, Lymphocytic, Chronic, B-Cell; Mice; Nitrophenols; Oncolytic Viruses; Piperazines; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Sulfonamides; Vesicular stomatitis Indiana virus | 2013 |
Obatoclax (GX15-070) triggers necroptosis by promoting the assembly of the necrosome on autophagosomal membranes.
Topics: Autophagy; Autophagy-Related Protein 5; Autophagy-Related Protein 7; Cell Death; Cell Line; Fas-Associated Death Domain Protein; GTPase-Activating Proteins; HEK293 Cells; Humans; Imidazoles; Indoles; Microtubule-Associated Proteins; Necrosis; Phagosomes; Pyrroles; Receptor-Interacting Protein Serine-Threonine Kinases; RNA Interference; RNA, Small Interfering | 2013 |
Gamma-secretase inhibition attenuates oxaliplatin-induced apoptosis through increased Mcl-1 and/or Bcl-xL in human colon cancer cells.
Topics: Adenocarcinoma; Amyloid Precursor Protein Secretases; Antineoplastic Agents; Apoptosis; bcl-X Protein; Cell Line, Tumor; Colonic Neoplasms; Cyclic S-Oxides; Drug Synergism; Humans; Indoles; Myeloid Cell Leukemia Sequence 1 Protein; Organoplatinum Compounds; Oxaliplatin; Pyrroles; RNA, Small Interfering; Signal Transduction; Thiadiazoles | 2013 |
Malaria parasite liver stages render host hepatocytes susceptible to mitochondria-initiated apoptosis.
Topics: Animals; Apoptosis; Hepatocytes; Indoles; Malaria; Mice; Mice, Inbred BALB C; Mitochondria; Parasite Load; Pyrroles; Signal Transduction | 2013 |
Autophagic cell death RIPs into tumors.
Topics: Autophagy; Cell Death; Humans; Indoles; Phagosomes; Pyrroles | 2013 |
Histone deacetylase inhibitors restore toxic BH3 domain protein expression in anoikis-resistant mammary and brain cancer stem cells, thereby enhancing the response to anti-ERBB1/ERBB2 therapy.
Topics: Animals; Anoikis; Antineoplastic Agents, Hormonal; Apoptosis Regulatory Proteins; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; bcl-X Protein; Brain Neoplasms; Breast Neoplasms; Cell Survival; Drug Resistance, Neoplasm; Epigenesis, Genetic; ErbB Receptors; Female; Gene Expression; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Histone Deacetylase Inhibitors; Humans; Indoles; Lapatinib; Mice; Mice, Nude; Myeloid Cell Leukemia Sequence 1 Protein; Neoplastic Stem Cells; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Quinazolines; Receptor, ErbB-2; RNA, Small Interfering; Valproic Acid; Xenograft Model Antitumor Assays | 2013 |
The pan-Bcl-2 blocker obatoclax promotes the expression of Puma, Noxa, and Bim mRNA and induces apoptosis in neoplastic mast cells.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; bcl-X Protein; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Drug Synergism; Female; Gene Expression Regulation, Neoplastic; Humans; Indoles; Male; Mast-Cell Sarcoma; Membrane Proteins; Middle Aged; Myeloid Cell Leukemia Sequence 1 Protein; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Pyrroles; RNA, Messenger | 2014 |
Single-agent obatoclax (GX15-070) potently induces apoptosis and pro-survival autophagy in head and neck squamous cell carcinoma cells.
Topics: Apoptosis; Autophagy; Carcinoma, Squamous Cell; Cell Survival; Head and Neck Neoplasms; Humans; Indoles; Inhibitory Concentration 50; Proto-Oncogene Proteins c-bcl-2; Pyrroles | 2014 |
BH3-mimetic drugs prevent tumour onset in an orthotopic mouse model of hepatoblastoma.
Topics: Animals; Biomimetic Materials; Biphenyl Compounds; Cell Transformation, Neoplastic; Cells, Cultured; Disease Models, Animal; Drug Evaluation, Preclinical; Hepatoblastoma; Humans; Indoles; Liver Neoplasms; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Mice, Nude; Mice, Transgenic; Nitrophenols; Peptide Fragments; Piperazines; Proto-Oncogene Proteins; Pyrroles; Sulfonamides | 2014 |
OBATOCLAX and ABT-737 induce ER stress responses in human melanoma cells that limit induction of apoptosis.
Topics: Antineoplastic Agents; Apoptosis; Autophagy; Biphenyl Compounds; Calcium; Cell Line, Tumor; Cytosol; Drug Resistance, Neoplasm; Endoplasmic Reticulum Stress; Humans; Indoles; Melanoma; Myeloid Cell Leukemia Sequence 1 Protein; Nitrophenols; Piperazines; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Sulfonamides; Unfolded Protein Response; Up-Regulation | 2013 |
Pan-Bcl-2 inhibitor, GX15-070 (obatoclax), decreases human T regulatory lymphocytes while preserving effector T lymphocytes: a rationale for its use in combination immunotherapy.
Topics: Apoptosis; Cells, Cultured; Combined Modality Therapy; CTLA-4 Antigen; Dose-Response Relationship, Drug; Down-Regulation; Female; Flow Cytometry; Forkhead Transcription Factors; Humans; Immunotherapy; Indoles; Leukocytes, Mononuclear; Lymphocyte Activation; Ovarian Neoplasms; Proto-Oncogene Proteins c-bcl-2; Pyrroles; T-Lymphocyte Subsets; T-Lymphocytes, Regulatory; Time Factors | 2014 |
Combination of AZD2281 (Olaparib) and GX15-070 (Obatoclax) results in synergistic antitumor activities in preclinical models of pancreatic cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; BRCA1 Protein; BRCA2 Protein; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Female; Humans; Indoles; Mice, Inbred BALB C; Mice, Nude; Necrosis; Pancreatic Neoplasms; Phthalazines; Piperazines; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Time Factors; Xenograft Model Antitumor Assays | 2014 |
Sequential single-agent obatoclax mesylate (GX15-070MS) followed by combination with rituximab in patients with previously untreated follicular lymphoma.
Topics: Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Humans; Indoles; Lymphoma, Follicular; Pyrroles; Rituximab; Treatment Outcome | 2014 |
Combined inhibition of NF-κB and Bcl-2 triggers synergistic reduction of viability and induces apoptosis in melanoma cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzamides; Cell Line, Tumor; Cell Survival; Cyclohexanones; Drug Synergism; Humans; Indoles; Melanoma; NF-kappa B; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Signal Transduction; Tumor Cells, Cultured | 2013 |
Obatoclax induces G1/G0-phase arrest via p38/p21(waf1/Cip1) signaling pathway in human esophageal cancer cells.
Topics: Antineoplastic Agents; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Cell Cycle; Cell Line, Tumor; Cell Survival; Cyclin-Dependent Kinase Inhibitor p21; Esophageal Neoplasms; Humans; Indoles; MAP Kinase Signaling System; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyrroles | 2014 |
Overcoming multiple drug resistance mechanisms in medulloblastoma.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; ATP Binding Cassette Transporter, Subfamily B; Cells, Cultured; Cerebellar Neoplasms; Child; Child, Preschool; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Humans; Indoles; Male; Medulloblastoma; Minor Histocompatibility Antigens; Myeloid Cell Leukemia Sequence 1 Protein; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Temozolomide; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2014 |
Complex disruption effect of natural polyphenols on Bcl-2-Bax: molecular dynamics simulation and essential dynamics study.
Topics: Algorithms; bcl-2-Associated X Protein; Humans; Hydrophobic and Hydrophilic Interactions; Indoles; Kinetics; Molecular Conformation; Molecular Dynamics Simulation; Molecular Structure; Multiprotein Complexes; Polyphenols; Principal Component Analysis; Protein Binding; Protein Structure, Tertiary; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Quercetin | 2015 |
Targeting SQSTM1/p62 induces cargo loading failure and converts autophagy to apoptosis via NBK/Bik.
Topics: Adaptor Proteins, Signal Transducing; Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Boronic Acids; Bortezomib; Cell Line, Tumor; Cells, Cultured; Cyclin T; Cyclin-Dependent Kinase 9; Cycloheximide; Flavonoids; Gene Expression Regulation; Heat-Shock Proteins; Humans; Indoles; Leupeptins; Membrane Proteins; Mice; Mice, Knockout; Mitochondrial Proteins; Piperidines; Protein Transport; Pyrazines; Pyrroles; RNA, Small Interfering; Sequestosome-1 Protein | 2014 |
Obatoclax overcomes resistance to cell death in aggressive thyroid carcinomas by countering Bcl2a1 and Mcl1 overexpression.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Resistance, Neoplasm; Female; Humans; Indoles; MAP Kinase Kinase Kinase 1; MAP Kinase Kinase Kinase 2; Mice, Transgenic; Minor Histocompatibility Antigens; Myeloid Cell Leukemia Sequence 1 Protein; Proto-Oncogene Proteins c-bcl-2; Pyrroles; RNA, Messenger; Thyroid Neoplasms; Tumor Burden | 2014 |
B cell lymphoma-2 (BCL-2) homology domain 3 (BH3) mimetics demonstrate differential activities dependent upon the functional repertoire of pro- and anti-apoptotic BCL-2 family proteins.
Topics: Aniline Compounds; Animals; Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Bcl-2-Like Protein 11; bcl-X Protein; Benzamides; Benzopyrans; BH3 Interacting Domain Death Agonist Protein; Biphenyl Compounds; HeLa Cells; Humans; Indoles; Membrane Proteins; Mice; Mitochondria, Liver; Mitochondrial Membranes; Molecular Mimicry; Myeloid Cell Leukemia Sequence 1 Protein; Nitriles; Nitrophenols; Permeability; Piperazines; Protein Interaction Domains and Motifs; Proto-Oncogene Proteins; Pyrroles; Sulfonamides; Sulfones; Unilamellar Liposomes | 2014 |
MCL-1 dependency of cisplatin-resistant cancer cells.
Topics: Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cisplatin; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; Indoles; Mice; Myeloid Cell Leukemia Sequence 1 Protein; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Pyrroles; RNA Interference | 2014 |
Pan-Bcl-2 inhibitor obatoclax delays cell cycle progression and blocks migration of colorectal cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Biphenyl Compounds; Cadherins; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Proliferation; Colorectal Neoplasms; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; G1 Phase Cell Cycle Checkpoints; Gene Expression; Humans; Indoles; Nitrophenols; Piperazines; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Sulfonamides | 2014 |
A liquid chromatography/tandem mass spectrometry method for determination of obatoclax in human plasma.
Topics: Apoptosis; Chromatography, High Pressure Liquid; Drug Stability; Humans; Indoles; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Quality Control; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2014 |
Obatoclax potentiates the cytotoxic effect of cytarabine on acute myeloid leukemia cells by enhancing DNA damage.
Topics: Antimetabolites, Antineoplastic; Child; Child, Preschool; Cytarabine; DNA Damage; Female; Humans; Indoles; Leukemia, Myeloid, Acute; Male; Pyrroles; U937 Cells | 2015 |
Combination of chloroquine and GX15-070 (obatoclax) results in synergistic cytotoxicity against pancreatic cancer cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; bcl-X Protein; Cell Line, Tumor; Chloroquine; Drug Synergism; Gene Expression Regulation, Neoplastic; Humans; Indoles; Myeloid Cell Leukemia Sequence 1 Protein; Pancreatic Neoplasms; Proto-Oncogene Proteins c-bcl-2; Pyrroles | 2014 |
Overexpression of Mcl-1L splice variant is associated with poor prognosis and chemoresistance in oral cancers.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alternative Splicing; Antineoplastic Agents; Cell Line, Tumor; Cisplatin; Drug Resistance, Neoplasm; Drug Synergism; Female; Gene Expression Regulation, Neoplastic; Humans; Indoles; Male; Middle Aged; Mouth Neoplasms; Myeloid Cell Leukemia Sequence 1 Protein; Prognosis; Protein Isoforms; Pyrroles; Young Adult | 2014 |
Obatoclax induces Beclin 1- and ATG5-dependent apoptosis and autophagy in adenoid cystic carcinoma cells.
Topics: Autophagy; Autophagy-Related Protein 5; Beclin-1; Carcinoma, Adenoid Cystic; Cell Line, Tumor; Cell Survival; Humans; Indoles; Prognosis; Pyrroles; Salivary Gland Neoplasms | 2015 |
Copper-obatoclax derivative complexes mediate DNA cleavage and exhibit anti-cancer effects in hepatocellular carcinoma.
Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cell Survival; Copper; DNA Cleavage; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Indoles; Liver Neoplasms; Molecular Structure; Organometallic Compounds; Pyrroles; Structure-Activity Relationship | 2015 |
Host-based Prophylaxis Successfully Targets Liver Stage Malaria Parasites.
Topics: Animals; Antimalarials; Cell Line; Disease Models, Animal; Female; Imidazoles; Indoles; Life Cycle Stages; Liver; Malaria; Malaria, Falciparum; Mice; Mice, Transgenic; Parasite Load; Piperazines; Plasmodium; Plasmodium falciparum; Post-Exposure Prophylaxis; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Tumor Suppressor Protein p53 | 2015 |
Obatoclax regulates the proliferation and fusion of osteoclast precursors through the inhibition of ERK activation by RANKL.
Topics: Animals; Apoptosis; Cell Fusion; Cell Proliferation; Cells, Cultured; Down-Regulation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression; Gene Silencing; Indoles; MAP Kinase Signaling System; Membrane Proteins; Mice, Inbred C57BL; Nerve Tissue Proteins; Osteoclasts; Pyrroles; RANK Ligand; Vacuolar Proton-Translocating ATPases | 2015 |
Mechanistic rationale for MCL1 inhibition during androgen deprivation therapy.
Topics: Animals; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Humans; Indoles; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Myeloid Cell Leukemia Sequence 1 Protein; Prostatic Neoplasms; Pyrroles; Random Allocation; Receptors, Androgen; Risk Factors; Transfection; Xenograft Model Antitumor Assays | 2015 |
The BH3-mimetic obatoclax reduces HIF-1α levels and HIF-1 transcriptional activity and sensitizes hypoxic colon adenocarcinoma cells to 5-fluorouracil.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Hypoxia; Cell Proliferation; Colonic Neoplasms; Down-Regulation; Drug Synergism; Fluorouracil; HCT116 Cells; HT29 Cells; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Indoles; Pyrroles; Transcriptional Activation | 2015 |
Optical properties of prodigiosin and obatoclax: action spectroscopy and theoretical calculations.
Topics: Antineoplastic Agents; Indoles; Isomerism; Mass Spectrometry; Models, Molecular; Molecular Conformation; Prodigiosin; Protons; Pyrroles; Sodium; Spectrophotometry, Ultraviolet | 2015 |
Inhibition of MCL-1 by obatoclax sensitizes Sp2/0-Ag14 hybridoma cells to glutamine deprivation-induced apoptosis.
Topics: Apoptosis; Biphenyl Compounds; Cell Line, Tumor; Cell Survival; Glutamine; Humans; Hybridomas; Indoles; Myeloid Cell Leukemia Sequence 1 Protein; Nitrophenols; Piperazines; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Sensitivity and Specificity; Sulfonamides | 2015 |
Cell death induction by the BH3 mimetic GX15-070 in thyroid carcinoma cells.
Topics: Apoptosis; Cell Death; Cell Line, Tumor; Cell Survival; Humans; Indoles; Molecular Targeted Therapy; Pyrroles; Thyroid Neoplasms | 2015 |
Obatoclax is a direct and potent antagonist of membrane-restricted Mcl-1 and is synthetic lethal with treatment that induces Bim.
Topics: Animals; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Cell Line, Tumor; Disease Models, Animal; Doxorubicin; Drug Synergism; Humans; Indoles; Lymphoma; Membrane Proteins; Mice; Myeloid Cell Leukemia Sequence 1 Protein; Proto-Oncogene Proteins; Pyrroles; Xenograft Model Antitumor Assays | 2015 |
Obatoclax as a perpetrator in drug-drug interactions and its efficacy in multidrug resistance cell lines.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Cell Line; Cell Line, Tumor; Cytochrome P-450 Enzyme System; Drug Interactions; Drug Resistance, Multiple; Gene Expression Regulation; Humans; Indoles; LLC-PK1 Cells; Mice; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pyrroles; Real-Time Polymerase Chain Reaction; RNA, Messenger; Swine | 2015 |
Pan-Bcl-2 inhibitor Obatoclax is a potent late stage autophagy inhibitor in colorectal cancer cells independent of canonical autophagy signaling.
Topics: Antineoplastic Agents; Autophagy; Biphenyl Compounds; Cell Culture Techniques; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Gene Expression Regulation, Neoplastic; HT29 Cells; Humans; Indoles; Nitrophenols; Piperazines; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Signal Transduction; Sulfonamides | 2015 |
Selective targeting of BCL6 induces oncogene addiction switching to BCL2 in B-cell lymphoma.
Topics: Animals; Biphenyl Compounds; Blotting, Western; Cell Proliferation; Drug Resistance, Neoplasm; Humans; Indoles; Lymphoma, Large B-Cell, Diffuse; Male; Mice; Mice, Nude; Nitrophenols; Peptide Fragments; Piperazines; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-bcl-6; Pyrroles; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Sulfonamides; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2016 |
Immuno-modulating properties of saliphenylhalamide, SNS-032, obatoclax, and gemcitabine.
Topics: Amides; Antineoplastic Agents; Antiviral Agents; Cells, Cultured; Coinfection; Cytokines; Deoxycytidine; Gemcitabine; Humans; Immunity, Innate; Immunologic Factors; Indoles; Influenza A virus; Influenza, Human; Interferon-alpha; Lipopolysaccharides; Macrophages; Oxazoles; Phosphoproteins; Pyrroles; RNA, Viral; Salicylates; Thiazoles; Virus Replication | 2016 |
Cell Death Induction by the Indirubin Derivative 7BIO and the BH3 Mimetic Drugs ABT-737 and GX15-070 in Medullary Thyroid Carcinoma Cells.
Topics: BH3 Interacting Domain Death Agonist Protein; Biphenyl Compounds; Carcinoma, Neuroendocrine; Cell Death; Cell Line, Tumor; Humans; Indoles; Molecular Mimicry; Nitrophenols; Piperazines; Protein Kinase Inhibitors; Pyrroles; Sulfonamides; Thyroid Neoplasms | 2016 |
Comparison of in vitro antileukemic activity of obatoclax and ABT-737.
Topics: Antineoplastic Agents; Apoptosis; Biphenyl Compounds; Cell Line, Tumor; Cell Survival; Flow Cytometry; Humans; Indoles; Leukemia; Nitrophenols; Piperazines; Pyrroles; Sulfonamides | 2016 |
Obatoclax impairs lysosomal function to block autophagy in cisplatin-sensitive and -resistant esophageal cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Cathepsin B; Cell Proliferation; Cisplatin; Drug Resistance, Neoplasm; Enzyme Inhibitors; Esophageal Neoplasms; Humans; Indoles; Lysosomes; Pyrroles; Tumor Cells, Cultured | 2016 |
The BH3 Mimetic Obatoclax Accumulates in Lysosomes and Causes Their Alkalinization.
Topics: Biological Transport; Biomimetic Materials; Cathepsins; Cell Death; Cell Line, Tumor; Humans; Hydrogen-Ion Concentration; Indoles; Lysosomes; Proto-Oncogene Proteins c-bcl-2; Pyrroles | 2016 |
[Synergistic anti-tumor effect of obatoclax and MG-132 in esophageal cancer cell line CaES-17].
Topics: Apoptosis; Caspase 9; Cell Cycle Checkpoints; Cell Line, Tumor; Esophageal Neoplasms; Histones; Humans; Indoles; Leupeptins; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Pyrroles | 2016 |
MCL-1 is the key target of adjuvant chemotherapy to reverse the cisplatin-resistance in NSCLC.
Topics: Antineoplastic Agents; bcl-2 Homologous Antagonist-Killer Protein; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cisplatin; Drug Resistance, Neoplasm; Drug Therapy, Combination; Humans; Indoles; Inhibitory Concentration 50; Lung Neoplasms; Myeloid Cell Leukemia Sequence 1 Protein; Proto-Oncogene Proteins c-bcl-2; Pyrroles | 2016 |
Obatoclax kills anaplastic thyroid cancer cells by inducing lysosome neutralization and necrosis.
Topics: Animals; Antineoplastic Agents; Apoptosis; Autophagy-Related Protein 5; Autophagy-Related Protein 7; Cell Proliferation; Enzyme Inhibitors; Humans; Indoles; Lysosomes; Mefloquine; Mice; Mice, Knockout; Necrosis; Proto-Oncogene Proteins c-bcl-2; Pyrroles; RNA Interference; RNA, Small Interfering; Spheroids, Cellular; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms; Tumor Cells, Cultured | 2016 |
Nanoparticle-Mediated Mitochondrial Damage Induces Apoptosis in Cancer.
Topics: alpha-Tocopherol; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Drug Carriers; HeLa Cells; Humans; Indoles; Mitochondria; Nanoparticles; Organophosphorus Compounds; Pyrroles | 2016 |
Codelivery of a miR-124 Mimic and Obatoclax by Cholesterol-Penetratin Micelles Simultaneously Induces Apoptosis and Inhibits Autophagic Flux in Breast Cancer in Vitro and in Vivo.
Topics: Animals; Antineoplastic Agents; Apoptosis; Autophagy; Blotting, Western; Breast Neoplasms; Carrier Proteins; Cell Proliferation; Cell-Penetrating Peptides; Cholesterol; Female; Humans; Indoles; MCF-7 Cells; Mice; Mice, Nude; Micelles; MicroRNAs; Pyrroles; Real-Time Polymerase Chain Reaction; Wound Healing | 2016 |
Smac mimetic LCL161 overcomes protective ER stress induced by obatoclax, synergistically causing cell death in multiple myeloma.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Regulatory Proteins; Caspases; Cell Line, Tumor; Down-Regulation; Drug Resistance, Neoplasm; Drug Synergism; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Heat-Shock Proteins; Humans; Indoles; Intracellular Signaling Peptides and Proteins; Mitochondrial Proteins; Multiple Myeloma; Neoplasm Recurrence, Local; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Thiazoles; Unfolded Protein Response; Up-Regulation; X-Box Binding Protein 1 | 2016 |
GLI inhibitor GANT61 kills melanoma cells and acts in synergy with obatoclax.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Synergism; GTP Phosphohydrolases; Humans; Indoles; Kruppel-Like Transcription Factors; Melanoma; Membrane Proteins; Mutation; Nuclear Proteins; Proto-Oncogene Proteins B-raf; Pyridines; Pyrimidines; Pyrroles; Zinc Finger Protein Gli2 | 2016 |
Regulation of kynurenine biosynthesis during influenza virus infection.
Topics: Animals; Antiviral Agents; Female; Gene Expression Regulation; Host-Pathogen Interactions; Humans; Immunologic Factors; Indoleamine-Pyrrole 2,3,-Dioxygenase; Indoles; Influenza A Virus, H1N1 Subtype; Interferons; Kynurenine; Lung; Macrophages; Metabolic Networks and Pathways; Mice; Mice, Inbred BALB C; Orthomyxoviridae Infections; Oxazoles; Oximes; Primary Cell Culture; Pyrroles; Sulfonamides; Thiazoles; Transcriptome; Tryptophan; Viral Nonstructural Proteins; Virus Replication | 2017 |
Obatoclax Inhibits Alphavirus Membrane Fusion by Neutralizing the Acidic Environment of Endocytic Compartments.
Topics: Animals; Antiviral Agents; Cell Line; Cell Membrane; Chikungunya virus; Cricetinae; Drug Resistance, Viral; Endosomes; Epithelial Cells; Gene Expression; Hepatocytes; Humans; Hydrogen-Ion Concentration; Indoles; Lysosomes; Membrane Fusion; Membrane Glycoproteins; Mutation; Neutral Red; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Semliki forest virus; Viral Envelope Proteins; Virus Internalization; Virus Replication; West Nile virus; Yellow fever virus; Zika Virus | 2017 |
Obatoclax, a Pan-BCL-2 Inhibitor, Targets Cyclin D1 for Degradation to Induce Antiproliferation in Human Colorectal Carcinoma Cells.
Topics: Carcinoma; Cell Proliferation; Colorectal Neoplasms; Cyclin D1; Down-Regulation; G1 Phase Cell Cycle Checkpoints; HCT116 Cells; HT29 Cells; Humans; Indoles; Proteolysis; Proto-Oncogene Proteins c-bcl-2; Pyrroles | 2016 |
Obatoclax, saliphenylhalamide and gemcitabine inhibit Zika virus infection in vitro and differentially affect cellular signaling, transcription and metabolism.
Topics: Amides; Antiviral Agents; Brain; Caspases; Deoxycytidine; Drug Combinations; Enzyme Inhibitors; Fetus; Gemcitabine; Humans; Indoles; Metabolic Networks and Pathways; Pyrroles; Retinal Pigment Epithelium; RNA, Viral; Salicylates; Signal Transduction; Virus Replication; Zika Virus | 2017 |
BH3 mimetics suppress CXCL12 expression in human malignant peripheral nerve sheath tumor cells.
Topics: Antineoplastic Agents; Biphenyl Compounds; Cell Line, Tumor; Chemokine CXCL12; Down-Regulation; Gene Expression Regulation, Neoplastic; Gossypol; Humans; Indoles; Molecular Mimicry; Neurilemmoma; Nitrophenols; Piperazines; Poly (ADP-Ribose) Polymerase-1; Protein Binding; Protein Interaction Domains and Motifs; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Sulfonamides | 2017 |
THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Survival; Chromatin; Cyclin-Dependent Kinase-Activating Kinase; Cyclin-Dependent Kinases; Female; Gain of Function Mutation; Gene Expression Regulation, Neoplastic; Humans; Indoles; Lymphoma, T-Cell; Male; Mice; Mice, Inbred NOD; Mice, SCID; Phenylenediamines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Pyrimidines; Pyrroles; Signal Transduction; STAT3 Transcription Factor; Transcription, Genetic; Treatment Outcome; Xenograft Model Antitumor Assays | 2017 |
Obatoclax and LY3009120 Efficiently Overcome Vemurafenib Resistance in Differentiated Thyroid Cancer.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Disease Models, Animal; Drug Resistance; Enzyme Inhibitors; Heterografts; Humans; Indoles; Mice, Nude; Phenylurea Compounds; Protein Multimerization; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-raf; Pyrimidines; Pyrroles; Sulfonamides; Thyroid Neoplasms; Treatment Outcome; Vemurafenib | 2017 |
Distinct activity of the bone-targeted gallium compound KP46 against osteosarcoma cells - synergism with autophagy inhibition.
Topics: Antineoplastic Combined Chemotherapy Protocols; Autophagy; Bone Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Movement; Drug Screening Assays, Antitumor; Drug Synergism; Humans; Indoles; Molecular Targeted Therapy; Organometallic Compounds; Osteosarcoma; Oxyquinoline; Pyrroles | 2017 |
Inhibition of Mitochondrial Matrix Chaperones and Antiapoptotic Bcl-2 Family Proteins Empower Antitumor Therapeutic Responses.
Topics: Aniline Compounds; Animals; Antineoplastic Agents; Apoptosis; Biomimetic Materials; Cell Line, Tumor; Cell Proliferation; Female; HSP90 Heat-Shock Proteins; Humans; Indoles; Male; Mice; Mice, SCID; Mitochondria; Peptide Fragments; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Sulfonamides; Xenograft Model Antitumor Assays | 2017 |
Breast cancer cell obatoclax response characterization using passivated-electrode insulator-based dielectrophoresis.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Proliferation; Cell Size; Drug Resistance, Neoplasm; Electrodes; Electrophoresis; Estrogen Antagonists; Female; Humans; Indoles; MCF-7 Cells; Microfluidic Analytical Techniques; Pyrroles | 2017 |
Molecular docking studies of bioactive compounds from Annona muricata Linn as potential inhibitors for Bcl-2, Bcl-w and Mcl-1 antiapoptotic proteins.
Topics: Annona; Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Regulatory Proteins; Aporphines; Binding Sites; Dioxoles; Gene Expression; Humans; Hydrophobic and Hydrophilic Interactions; Indoles; Molecular Docking Simulation; Myeloid Cell Leukemia Sequence 1 Protein; Plant Extracts; Plant Leaves; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Structural Homology, Protein | 2018 |
Effects of obatoclax combined with gemcitabine on the biological activity of pancreatic cancer cells under hypoxic conditions.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cadherins; Cell Hypoxia; Cell Line, Tumor; Cell Movement; Deoxycytidine; Epithelial-Mesenchymal Transition; Gemcitabine; Humans; Indoles; Neoplasm Invasiveness; Pancreatic Neoplasms; Pyrroles; Tumor Suppressor Protein p53 | 2018 |
Chemoresistance of cancer floating cells is independent of their ability to form 3D structures: Implications for anticancer drug screening.
Topics: Antibodies; Antigens, CD; Antineoplastic Agents; Cadherins; Cell Adhesion; Cell Culture Techniques; Cell Survival; Colchicine; Culture Media, Serum-Free; Drug Resistance, Neoplasm; Female; Humans; Hydroxyurea; Indoles; Male; MCF-7 Cells; Neoplasms; PC-3 Cells; Phenotype; Pyrroles; Spheroids, Cellular | 2019 |
Targeting EIF4E signaling with ribavirin in infant acute lymphoblastic leukemia.
Topics: Cell Line, Tumor; Child, Preschool; Drug Resistance, Neoplasm; Eukaryotic Initiation Factor-4E; Gene Expression Profiling; Gene Expression Regulation, Leukemic; Humans; Indoles; Infant; Microarray Analysis; Molecular Targeted Therapy; Multigene Family; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Biosynthesis; Pyrroles; Ribavirin; Signal Transduction | 2019 |
Obatoclax, a BH3 Mimetic, Enhances Cisplatin-Induced Apoptosis and Decreases the Clonogenicity of Muscle Invasive Bladder Cancer Cells via Mechanisms That Involve the Inhibition of Pro-Survival Molecules as Well as Cell Cycle Regulators.
Topics: bcl-X Protein; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cisplatin; Cyclin D1; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Dose-Response Relationship, Drug; Drug Synergism; Gene Expression Regulation, Neoplastic; Humans; Indoles; Neoplasm Invasiveness; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Urinary Bladder; Urinary Bladder Neoplasms | 2019 |
[Bortezomib and obatoclax for dual blockade of protein degradation pathways show synergistic anti-tumor effect in human acute T lymphoblastic leukemia cells].
Topics: Antineoplastic Agents; Apoptosis; Bortezomib; Cell Line, Tumor; Drug Synergism; Endoplasmic Reticulum Chaperone BiP; Humans; Indoles; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proteolysis; Proto-Oncogene Proteins c-bcl-2; Pyrroles | 2019 |
Novel Antiviral Activities of Obatoclax, Emetine, Niclosamide, Brequinar, and Homoharringtonine.
Topics: Animals; Antiviral Agents; Biphenyl Compounds; Cell Culture Techniques; Chlorocebus aethiops; Dogs; Emetine; Enterovirus B, Human; Herpesvirus 2, Human; HIV-1; Homoharringtonine; Humans; Indoles; Madin Darby Canine Kidney Cells; Niclosamide; Pyrroles; Vero Cells; Virus Diseases; Viruses | 2019 |
GX15-070 (Obatoclax), a Bcl-2 family proteins inhibitor engenders apoptosis and pro-survival autophagy and increases Chemosensitivity in neuroblastoma.
Topics: Adrenal Gland Neoplasms; Animals; Antineoplastic Agents; Apoptosis; Autophagy; Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm; Drug Synergism; Female; Humans; Hydroxychloroquine; Indoles; Male; Mice; Mice, Inbred NOD; Mice, SCID; Neuroblastoma; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Tumor Burden; Xenograft Model Antitumor Assays | 2019 |
Obatoclax, a Pan-BCL-2 Inhibitor, Downregulates Survivin to Induce Apoptosis in Human Colorectal Carcinoma Cells Via Suppressing WNT/β-catenin Signaling.
Topics: Apoptosis; beta Catenin; Biomarkers, Tumor; Cell Proliferation; Colorectal Neoplasms; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; Indoles; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Survivin; Tumor Cells, Cultured; Wnt Proteins | 2020 |
Identification of anisomycin, prodigiosin and obatoclax as compounds with broad-spectrum anti-parasitic activity.
Topics: Animals; Anisomycin; Antiparasitic Agents; Cell Line; Cell Survival; Drug Repositioning; Fibroblasts; Humans; Indoles; Mice; Parasites; Parasitic Sensitivity Tests; Prodigiosin; Pyrroles; Rats | 2020 |
Spatial targeting of Bcl-2 on endoplasmic reticulum and mitochondria in cancer cells by lipid nanoparticles.
Topics: Apoptosis; Endoplasmic Reticulum; HeLa Cells; Humans; Indoles; Lipids; Mitochondria; Molecular Structure; Nanoparticles; Particle Size; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Surface Properties | 2020 |
The pan-Bcl-2 inhibitor obatoclax promotes differentiation and apoptosis of acute myeloid leukemia cells.
Topics: Antineoplastic Agents; Apoptosis; Cell Differentiation; HL-60 Cells; Humans; Indoles; Leukemia, Myeloid, Acute; Proto-Oncogene Proteins c-bcl-2; Pyrroles | 2020 |
Potential Antiviral Options against SARS-CoV-2 Infection.
Topics: Amodiaquine; Animals; Antiviral Agents; Betacoronavirus; Caco-2 Cells; Cell Line, Tumor; Chlorocebus aethiops; Coronavirus Infections; COVID-19; COVID-19 Serotherapy; Drug Therapy, Combination; Emetine; HEK293 Cells; Homoharringtonine; HT29 Cells; Humans; Immune Sera; Immunization, Passive; Indoles; Nelfinavir; Neutralization Tests; Pandemics; Pneumonia, Viral; Pyrans; Pyrroles; SARS-CoV-2; Vero Cells | 2020 |
Biomimetic nanoparticle loading obatoclax mesylate for the treatment of non-small-cell lung cancer (NSCLC) through suppressing Bcl-2 signaling.
Topics: A549 Cells; Animals; Antineoplastic Agents; Apoptosis; Biomimetics; Carcinoma, Non-Small-Cell Lung; Cell Proliferation; Delayed-Action Preparations; Drug Compounding; Drug Liberation; Drug Stability; Humans; Indoles; Lung Neoplasms; Male; Mice, Inbred C57BL; Nanoparticles; Polylactic Acid-Polyglycolic Acid Copolymer; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Signal Transduction; Solubility; Xenograft Model Antitumor Assays | 2020 |
Combinations of proteasome inhibitors with obatoclax are effective for small cell lung cancer.
Topics: Animals; Antineoplastic Agents; Apoptosis; Bortezomib; Cell Line, Tumor; Drug Synergism; Forkhead Box Protein M1; HEK293 Cells; Humans; Indoles; Lung Neoplasms; Mice, Nude; Myeloid Cell Leukemia Sequence 1 Protein; Oligopeptides; Proteasome Inhibitors; Pyrroles; Small Cell Lung Carcinoma; Up-Regulation; Xenograft Model Antitumor Assays | 2021 |
Berberine and Obatoclax Inhibit SARS-Cov-2 Replication in Primary Human Nasal Epithelial Cells In Vitro.
Topics: Adolescent; Animals; Antiviral Agents; Berberine; Cells, Cultured; Chlorocebus aethiops; COVID-19; Epithelial Cells; Humans; Indoles; Male; Pyrroles; RNA, Viral; SARS-CoV-2; Vero Cells; Virus Replication | 2021 |
Obatoclax inhibits SARS-CoV-2 entry by altered endosomal acidification and impaired cathepsin and furin activity in vitro.
Topics: Cathepsins; COVID-19; Furin; Humans; Hydrogen-Ion Concentration; Indoles; Pyrroles; SARS-CoV-2; Spike Glycoprotein, Coronavirus; Virus Internalization | 2022 |
Dual mTORC1/2 inhibition compromises cell defenses against exogenous stress potentiating Obatoclax-induced cytotoxicity in atypical teratoid/rhabdoid tumors.
Topics: Animals; Humans; Indoles; Mechanistic Target of Rapamycin Complex 1; Mice; Pyrroles; Rhabdoid Tumor; TOR Serine-Threonine Kinases | 2022 |
Boosting nutrient starvation-dominated cancer therapy through curcumin-augmented mitochondrial Ca
Topics: Apoptosis; Autophagy; Cell Line, Tumor; Curcumin; Glucose; Humans; Indoles; Neoplasms; Nutrients; Pyrroles; Starvation | 2022 |