Page last updated: 2024-08-18

pyrroles and forodesine

pyrroles has been researched along with forodesine in 43 studies

Research

Studies (43)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	3 (6.98)	18.2507
2000's	38 (88.37)	29.6817
2010's	2 (4.65)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Bagdassarian, CK; Furneaux, RH; Miles, RW; Schramm, VL; Tyler, PC	1
Furneaux, RH; Girvin, ME; Grubmeyer, C; Kicska, G; Li, CM; Schramm, VL; Tyler, PC; Xu, Y	1
Almo, SC; Cahill, SM; Furneaux, RH; Girvin, ME; Grubmeyer, C; Li, CM; Schramm, VL; Shi, W; Tyler, PC	1
Angeletti, RH; Kicska, G; Miles, RW; Nieves, E; Schramm, VL; Wang, F	1
Almo, SC; Fedorov, A; Fedorov, E; Furneaux, RH; Gainsford, GJ; Hanson, JC; Kicska, G; Larese, JZ; Schramm, VL; Shi, W; Tyler, PC	1
Fairchild, C; Furneaux, RH; Hörig, H; Kaufman, HL; Kicska, GA; Long, L; Schramm, VL; Tyler, PC	1
Ananth, SL; Bantia, S; Horn, LL; Hutchison, TL; Kilpatrick, JM; Miller, PJ; Montgomery, JA; Morris, PE; Parker, CD; Sandhu, JS	1
Basso, LA; Blanchard, JS; Furneaux, RH; Santos, DS; Schramm, VL; Shi, W; Tyler, PC	1
Almo, SC; Basso, LA; Blanchard, JS; Furneaux, RH; Santos, DS; Schramm, VL; Shi, W; Tyler, PC	1
Evans, GB; Furneaux, RH; Kicska, GA; Kim, K; Schramm, VL; Tyler, PC	1
Schramm, VL	4
Ananth, SL; Babu, YS; Banti, S; Horn, LL; Miller, PJ; Parker, CD; Sandhu, JS	1
Almo, SC; Cahill, SM; Evans, GB; Fedorov, A; Furneaux, RH; Kicska, GA; Lewandowicz, A; Schramm, VL; Shi, W; Tyler, PC	1
Cervetto, L; Demontis, GC; Longoni, B; Macchia, B; Macchia, M; Minutolo, F; Orlandini, E; Ortore, G; Papi, C; Sbrana, A	1
Babu, YS; Bennett, JC; Kilpatrick, JM; Moore, DR; Morris, PE; Phillips, D; Serota, DG	1
Basso, LA; Cahill, SM; Evans, GB; Furneaux, RH; Girvin, ME; Grubmeyer, C; Lewandowicz, A; McDermott, A; Santos, DS; Sauve, AA; Schramm, VL; Tyler, PC; Zech, SG	1
Almo, SC; Basso, LA; Evans, GB; Furneaux, RH; Lewandowicz, A; Santos, DS; Schramm, VL; Shi, W; Tyler, PC	1
Bae, DS; Campain, JA; Handa, RJ; Yang, RS	1
Ananth, SL; Bantia, S; Horn, LL; Parker, CD; Upshaw, R	1
Evans, GB; Furneaux, RH; Lewandowicz, A; Schramm, VL; Tyler, PC	1
Basso, LA; Canduri, F; Dias, MV; Filgueira de Azevedo, W; Marangoni dos Santos, D; Mendes, MA; Palma, MS; Pereira, JH; Santos, DS; Silva, RG	1
Aronov, PA; Green, PG; Ngo, M; Patterson, TJ; Reznikova, TV; Rice, RH	1
Almo, SC; Evans, GB; Furneaux, RH; Schramm, VL; Shi, W; Singh, V; Tyler, PC	1
Cahill, SM; Callender, RH; Deng, H; Furneaux, RH; Girvin, ME; Lewandowicz, A; Schramm, VL; Tyler, PC	1
Almo, SC; Evans, GB; Furneaux, RH; Kicska, GA; Kim, K; Lewandowicz, A; Schramm, VL; Shi, W; Ting, LM; Tyler, PC	1
Evans, GB; Furneaux, RH; Schramm, VL; Singh, V; Tyler, PC	1
Callender, R; Deng, H; Lewandowicz, A; Schramm, VL	1
Gregus, Z; Németi, B	1
Basso, LA; Canduri, F; de Azevedo, WF; Fadel, V; Palma, MS; Santos, DS	1
Cornell, KA; Evans, GB; Furneaux, RH; Howell, PL; Lee, JE; Riscoe, MK; Schramm, VL; Singh, V; Tyler, PC	1
Lewandowicz, A	1
Evans, GB; Furneaux, RH; Kim, K; Lenz, DH; Lewandowicz, A; Mee, S; Painter, GF; Ringia, EA; Schramm, VL; Ting, LM; Tyler, PC; Zubkova, OV	1
Basso, LA; Canduri, F; de Azevedo, WF; dos Santos, DM; Palma, MS; Santos, DS; Silva, RG	1
Ayres, M; Bantia, S; Davisson, J; Du, M; Faderl, S; Gandhi, V; Harman, L; Kantarjian, H; Kilpatrick, JM; Plunkett, W; Thomas, D; Wierda, WG	1
Barlow, J; Steyaert, J; Versées, W	1
Balakrishnan, K; Gandhi, V; Keating, MJ; Nimmanapalli, R; Ravandi, F	1
Gandhi, V; Ravandi, F	1
Delso, I; Merino, P; Tejero, T	1
Cassera, MB; Hazleton, KZ; Schramm, VL; Zhang, Y	1
Clinch, K; Evans, GB; Freitas, EO; Guan, R; Meyer-Fernandes, JR; Nico, D; Palatnik-de-Sousa, CB; Schramm, VL; Tyler, PC	1

Reviews

7 review(s) available for pyrroles and forodesine

Article	Year
Development of transition state analogues of purine nucleoside phosphorylase as anti-T-cell agents. Biochimica et biophysica acta, 2002, Jul-18, Volume: 1587, Issue:2-3 Topics: Animals; Antineoplastic Agents; Drug Design; Enzyme Inhibitors; Humans; Leukemia, T-Cell; Mice; Nucleosides; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; Static Electricity; T-Lymphocytes; Transplantation, Heterologous	2002
Immucillins as antibiotics for T-cell proliferation and malaria. Nucleosides, nucleotides & nucleic acids, 2004, Volume: 23, Issue:8-9 Topics: Animals; Anti-Bacterial Agents; Cell Proliferation; Deoxyguanosine; Erythrocytes; Humans; Hypoxanthine; Kinetics; Lymphocyte Activation; Malaria; Models, Chemical; Phenotype; Plasmodium falciparum; Purine Nucleosides; Purines; Pyrimidinones; Pyrroles; T-Lymphocytes	2004
Enzymatic transition states: thermodynamics, dynamics and analogue design. Archives of biochemistry and biophysics, 2005, Jan-01, Volume: 433, Issue:1 Topics: Animals; Catalysis; Crystallography, X-Ray; Deuterium; Drug Design; Enzyme Inhibitors; Enzymes; Humans; Hydrogen; Hydrogen Bonding; Inosine; Kinetics; Models, Molecular; Motion; Protein Conformation; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; Static Electricity; Substrate Specificity; Thermodynamics	2005
[Tight binding transition state analogues of purine nucleoside phosphorylase--meaning, design and properties]. Postepy biochemii, 2004, Volume: 50, Issue:3 Topics: Animals; Enzyme Inhibitors; Humans; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; Structure-Activity Relationship	2004
Novel purine nucleoside analogues for T-cell-lineage acute lymphoblastic leukaemia and lymphoma. Expert opinion on investigational drugs, 2006, Volume: 15, Issue:12 Topics: Adult; Animals; Antimetabolites, Antineoplastic; Arabinonucleosides; Child; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Deoxyguanosine; Drug Design; Drug Screening Assays, Antitumor; Drugs, Investigational; Humans; Leukemia-Lymphoma, Adult T-Cell; Leukemia, Experimental; Lymphoma, T-Cell; Mice; Neoplasm Proteins; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; T-Lymphocytes	2006
Current developments in the synthesis and biological activity of aza-C-nucleosides: immucillins and related compounds. Current medicinal chemistry, 2008, Volume: 15, Issue:10 Topics: Adenine; Adenosine; Aza Compounds; Glycoside Hydrolases; N-Glycosyl Hydrolases; Nucleosides; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; Pyrrolidines	2008
Purine and pyrimidine pathways as targets in Plasmodium falciparum. Current topics in medicinal chemistry, 2011, Volume: 11, Issue:16 Topics: Antimalarials; Binding Sites; Drug Design; Enzyme Inhibitors; Humans; Malaria, Falciparum; Models, Molecular; Plasmodium falciparum; Protein Binding; Protozoan Proteins; Purine Nucleosides; Purines; Pyrimidines; Pyrimidinones; Pyrroles; Substrate Specificity	2011

Trials

1 trial(s) available for pyrroles and forodesine

Article	Year
A proof-of-principle pharmacokinetic, pharmacodynamic, and clinical study with purine nucleoside phosphorylase inhibitor immucillin-H (BCX-1777, forodesine). Blood, 2005, Dec-15, Volume: 106, Issue:13 Topics: Adult; Aged; Deoxyguanine Nucleotides; Enzyme Inhibitors; Female; Humans; Leukemia, Lymphoid; Male; Middle Aged; Molecular Structure; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; Treatment Outcome	2005

Article

Year

A proof-of-principle pharmacokinetic, pharmacodynamic, and clinical study with purine nucleoside phosphorylase inhibitor immucillin-H (BCX-1777, forodesine).

Blood, 2005, Dec-15, Volume: 106, Issue:13

Topics: Adult; Aged; Deoxyguanine Nucleotides; Enzyme Inhibitors; Female; Humans; Leukemia, Lymphoid; Male; Middle Aged; Molecular Structure; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; Treatment Outcome

2005

Other Studies

35 other study(ies) available for pyrroles and forodesine

Article	Year
One-third-the-sites transition-state inhibitors for purine nucleoside phosphorylase. Biochemistry, 1998, Jun-16, Volume: 37, Issue:24 Topics: Animals; Cattle; Enzyme Inhibitors; Humans; Kinetics; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; Structure-Activity Relationship; Substrate Specificity; T-Lymphocytes	1998
Transition-state analogs as inhibitors of human and malarial hypoxanthine-guanine phosphoribosyltransferases. Nature structural biology, 1999, Volume: 6, Issue:6 Topics: Animals; Binding Sites; Catalysis; Diphosphates; Drug Design; Enzyme Inhibitors; Guanosine Monophosphate; Humans; Hydrogen Bonding; Hypoxanthine; Hypoxanthine Phosphoribosyltransferase; Inosine Monophosphate; Kinetics; Magnesium Compounds; Nuclear Magnetic Resonance, Biomolecular; Phosphoribosyl Pyrophosphate; Phosphorylation; Plasmodium falciparum; Protein Binding; Protons; Purine Nucleosides; Pyrimidinones; Pyrroles	1999
The 2.0 A structure of malarial purine phosphoribosyltransferase in complex with a transition-state analogue inhibitor. Biochemistry, 1999, Aug-03, Volume: 38, Issue:31 Topics: Animals; Catalytic Domain; Crystallography, X-Ray; Enzyme Inhibitors; Humans; Macromolecular Substances; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Pentosyltransferases; Plasmodium falciparum; Protein Conformation; Protein Folding; Protein Structure, Secondary; Protons; Purine Nucleosides; Pyrimidinones; Pyrroles	1999
Immucillin-H binding to purine nucleoside phosphorylase reduces dynamic solvent exchange. Protein science : a publication of the Protein Society, 2000, Volume: 9, Issue:9 Topics: Amino Acid Sequence; Mass Spectrometry; Models, Molecular; Molecular Sequence Data; Protein Binding; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; Solvents	2000
Transition state structure of purine nucleoside phosphorylase and principles of atomic motion in enzymatic catalysis. Biochemistry, 2001, Jan-30, Volume: 40, Issue:4 Topics: Animals; Binding Sites; Catalysis; Cattle; Crystallography, X-Ray; Deuterium; Electron Transport; Enzyme Inhibitors; Hydrolysis; Inosine; Macromolecular Substances; Motion; Phosphates; Protein Conformation; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles	2001
Immucillin H, a powerful transition-state analog inhibitor of purine nucleoside phosphorylase, selectively inhibits human T lymphocytes. Proceedings of the National Academy of Sciences of the United States of America, 2001, Apr-10, Volume: 98, Issue:8 Topics: Apoptosis; Cell Division; Deoxyguanine Nucleotides; Enzyme Inhibitors; Humans; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; T-Lymphocytes; Tumor Cells, Cultured	2001
Purine nucleoside phosphorylase inhibitor BCX-1777 (Immucillin-H)--a novel potent and orally active immunosuppressive agent. International immunopharmacology, 2001, Volume: 1, Issue:6 Topics: Administration, Oral; Animals; Biological Availability; Enzyme Inhibitors; Graft vs Host Reaction; Guanosine Triphosphate; Immunosuppressive Agents; Indicators and Reagents; Injections, Intravenous; Lymphocyte Culture Test, Mixed; Mice; Mice, Inbred BALB C; Mice, SCID; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; Survival Analysis; T-Lymphocytes	2001
Purine nucleoside phosphorylase from Mycobacterium tuberculosis. Analysis of inhibition by a transition-state analogue and dissection by parts. Biochemistry, 2001, Jul-27, Volume: 40, Issue:28 Topics: Binding, Competitive; Catalysis; Cloning, Molecular; Enzyme Inhibitors; Gene Expression Regulation, Bacterial; Hydrogen-Ion Concentration; Kinetics; Molecular Weight; Mycobacterium tuberculosis; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; Recombinant Proteins	2001
Structures of purine nucleoside phosphorylase from Mycobacterium tuberculosis in complexes with immucillin-H and its pieces. Biochemistry, 2001, Jul-27, Volume: 40, Issue:28 Topics: Actinomycetales; Animals; Binding Sites; Catalysis; Cattle; Enzyme Inhibitors; Enzyme Stability; Escherichia coli; Macromolecular Substances; Models, Molecular; Mycobacterium tuberculosis; Phosphates; Protein Conformation; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles	2001
Purine-less death in Plasmodium falciparum induced by immucillin-H, a transition state analogue of purine nucleoside phosphorylase. The Journal of biological chemistry, 2002, Feb-01, Volume: 277, Issue:5 Topics: Animals; Biological Transport; Cell Death; Enzyme Inhibitors; Erythrocytes; Humans; Hypoxanthine; Kinetics; Models, Biological; Plasmodium falciparum; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Purines; Pyrimidinones; Pyrroles; Time Factors	2002
Comparison of in vivo efficacy of BCX-1777 and cyclosporin in xenogeneic graft-vs.-host disease: the role of dGTP in antiproliferative action of BCX-1777. International immunopharmacology, 2002, Volume: 2, Issue:7 Topics: Animals; Cyclosporine; Deoxyguanine Nucleotides; Dogs; Drug Therapy, Combination; Graft vs Host Disease; Growth Inhibitors; Humans; Immunosuppressive Agents; Lymphocytes; Macaca fascicularis; Mice; Mice, Inbred BALB C; Mice, SCID; Purine Nucleosides; Pyrimidinones; Pyrroles; Rats; Rats, Sprague-Dawley; Survival Rate; Transplantation, Heterologous	2002
Atomic dissection of the hydrogen bond network for transition-state analogue binding to purine nucleoside phosphorylase. Biochemistry, 2002, Dec-10, Volume: 41, Issue:49 Topics: Animals; Asparagine; Binding Sites; Catalysis; Cattle; Crystallography, X-Ray; Enzyme Inhibitors; Glutamic Acid; Hydrogen Bonding; Hydrogen-Ion Concentration; Hypoxanthine; Imines; Nuclear Magnetic Resonance, Biomolecular; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; Ribonucleosides; Static Electricity; Substrate Specificity; Thermodynamics	2002
New N-n-propyl-substituted 3-aryl- and 3-cyclohexylpiperidines as partial agonists at the D4 dopamine receptor. Journal of medicinal chemistry, 2003, Jan-02, Volume: 46, Issue:1 Topics: Animals; Binding, Competitive; Corpus Striatum; Crystallography, X-Ray; Dopamine Agonists; Guanine Nucleotides; Guinea Pigs; In Vitro Techniques; Male; Melatonin; Piperidines; Purine Nucleosides; Pyrimidinones; Pyrroles; Radioligand Assay; Receptors, Dopamine D2; Receptors, Dopamine D4; Retina; Structure-Activity Relationship	2003
Intravenous and oral pharmacokinetic study of BCX-1777, a novel purine nucleoside phosphorylase transition-state inhibitor. In vivo effects on blood 2'-deoxyguanosine in primates. International immunopharmacology, 2003, Volume: 3, Issue:4 Topics: Administration, Oral; Animals; Area Under Curve; Biological Availability; Deoxyguanosine; Enzyme Inhibitors; Erythrocytes; Injections, Intravenous; Inosine; Macaca fascicularis; Male; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles	2003
Ionic states of substrates and transition state analogues at the catalytic sites of N-ribosyltransferases. Biochemistry, 2003, May-20, Volume: 42, Issue:19 Topics: Catalytic Domain; Guanosine; Guanosine Monophosphate; Humans; Hydrogen-Ion Concentration; Hypoxanthine Phosphoribosyltransferase; In Vitro Techniques; Ions; Kinetics; Molecular Structure; Mycobacterium tuberculosis; Nuclear Magnetic Resonance, Biomolecular; Phosphorylation; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; Recombinant Proteins; Substrate Specificity	2003
Over-the-barrier transition state analogues and crystal structure with Mycobacterium tuberculosis purine nucleoside phosphorylase. Biochemistry, 2003, May-27, Volume: 42, Issue:20 Topics: Catalytic Domain; Crystallography, X-Ray; Inosine; Kinetics; Models, Molecular; Molecular Mimicry; Mycobacterium tuberculosis; Protein Conformation; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; Static Electricity; Substrate Specificity	2003
Gene expression patterns as potential molecular biomarkers for malignant transformation in human keratinocytes treated with MNNG, arsenic, or a metal mixture. Toxicological sciences : an official journal of the Society of Toxicology, 2003, Volume: 74, Issue:1 Topics: Animals; Arsenates; Bile; Biotransformation; Chromatography, High Pressure Liquid; Dithiothreitol; Enzyme Inhibitors; Erythrocytes; Humans; In Vitro Techniques; Inosine; Male; Oxidation-Reduction; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; Rats; Rats, Wistar; Spectrophotometry, Atomic; Sulfhydryl Reagents	2003
Mechanism of inhibition of T-acute lymphoblastic leukemia cells by PNP inhibitor--BCX-1777. International immunopharmacology, 2003, Volume: 3, Issue:6 Topics: Apoptosis; Cell Division; Cell Line; Culture Media; Half-Life; HIV Reverse Transcriptase; Humans; Lamivudine; Leukemia-Lymphoma, Adult T-Cell; Lymphocytes; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; Reverse Transcriptase Inhibitors; Stavudine	2003
Exploring structure-activity relationships of transition state analogues of human purine nucleoside phosphorylase. Journal of medicinal chemistry, 2003, Jul-17, Volume: 46, Issue:15 Topics: Animals; Cattle; Enzyme Inhibitors; Humans; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; Structure-Activity Relationship	2003
Structural basis for inhibition of human PNP by immucillin-H. Biochemical and biophysical research communications, 2003, Oct-03, Volume: 309, Issue:4 Topics: Crystallography, X-Ray; Enzyme Inhibitors; Humans; Ligands; Models, Molecular; Protein Conformation; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles	2003
Transition state analogues for enzymes of nucleic acid metabolism. Nucleic acids research. Supplement (2001), 2003, Issue:3 Topics: Animals; Cattle; Enzyme Inhibitors; Enzymes; Humans; Kinetics; Nucleic Acids; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; Ricin	2003
Biological activity of inorganic arsenic and antimony reflects oxidation state in cultured human keratinocytes. Chemical research in toxicology, 2003, Volume: 16, Issue:12 Topics: Animals; Antimony; Arsenic; Biotransformation; Cattle; Cell Line; Dose-Response Relationship, Drug; Enzyme Induction; Enzyme Inhibitors; Fibroblasts; Guanine; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Keratinocytes; Membrane Proteins; Oxidation-Reduction; Protein Precursors; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; Spleen	2003
Picomolar transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase and X-ray structure with MT-immucillin-A. Biochemistry, 2004, Jan-13, Volume: 43, Issue:1 Topics: Binding Sites; Catalysis; Crystallography, X-Ray; Enzyme Inhibitors; Humans; Phosphates; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; Recombinant Proteins; Ribitol	2004
Assignment of downfield proton resonances in purine nucleoside phosphorylase immucillin-H complex by saturation-transferred NOEs. Biochemistry, 2004, Feb-24, Volume: 43, Issue:7 Topics: Binding, Competitive; Catalysis; Enzyme Activation; Enzyme Inhibitors; Humans; Hydrogen Bonding; Nuclear Magnetic Resonance, Biomolecular; Protein Binding; Protons; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; Recombinant Proteins; Solutions; Thermodynamics	2004
Plasmodium falciparum purine nucleoside phosphorylase: crystal structures, immucillin inhibitors, and dual catalytic function. The Journal of biological chemistry, 2004, Apr-30, Volume: 279, Issue:18 Topics: Animals; Catalysis; Catalytic Domain; Crystallography, X-Ray; Enzyme Inhibitors; Humans; Hydrophobic and Hydrophilic Interactions; Methylthioinosine; Molecular Structure; Plasmodium falciparum; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles	2004
Targeting the polyamine pathway with transition-state analogue inhibitors of 5'-methylthioadenosine phosphorylase. Journal of medicinal chemistry, 2004, Jun-03, Volume: 47, Issue:12 Topics: Adenine; Humans; Polyamines; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; Pyrrolidines; Stereoisomerism; Structure-Activity Relationship	2004
Activating the phosphate nucleophile at the catalytic site of purine nucleoside phosphorylase: a vibrational spectroscopic study. Journal of the American Chemical Society, 2004, Aug-11, Volume: 126, Issue:31 Topics: Animals; Binding Sites; Catalysis; Cattle; Humans; Hydrogen Bonding; Kinetics; Organophosphates; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Thermodynamics	2004
Glutathione-dependent reduction of arsenate in human erythrocytes--a process independent of purine nucleoside phosphorylase. Toxicological sciences : an official journal of the Society of Toxicology, 2004, Volume: 82, Issue:2 Topics: Arsenates; Arsenite Transporting ATPases; Blood Glucose; Dithiothreitol; Erythrocytes; Ferricyanides; Glucose Oxidase; Glutathione; Humans; In Vitro Techniques; Inosine; Ion Pumps; Multienzyme Complexes; NADP; Oxidation-Reduction; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; Pyruvic Acid; Spectrophotometry, Atomic	2004
New catalytic mechanism for human purine nucleoside phosphorylase. Biochemical and biophysical research communications, 2005, Feb-18, Volume: 327, Issue:3 Topics: Acyclovir; Binding Sites; Catalysis; Crystallography, X-Ray; Enzyme Inhibitors; Humans; Models, Molecular; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles	2005
Structural rationale for the affinity of pico- and femtomolar transition state analogues of Escherichia coli 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase. The Journal of biological chemistry, 2005, May-06, Volume: 280, Issue:18 Topics: Deoxyadenosines; Enzyme Inhibitors; Escherichia coli; Models, Molecular; N-Glycosyl Hydrolases; Purine Nucleosides; Pyrimidinones; Pyrroles; Thionucleosides	2005
Energetic mapping of transition state analogue interactions with human and Plasmodium falciparum purine nucleoside phosphorylases. The Journal of biological chemistry, 2005, Aug-26, Volume: 280, Issue:34 Topics: Animals; Aspartic Acid; Cattle; Humans; Hydrogen-Ion Concentration; Kinetics; Models, Chemical; Plasmodium falciparum; Polyamines; Protein Binding; Protein Structure, Tertiary; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Purines; Pyrimidinones; Pyrroles; Static Electricity; Substrate Specificity; T-Lymphocytes	2005
Structure of human PNP complexed with ligands. Acta crystallographica. Section D, Biological crystallography, 2005, Volume: 61, Issue:Pt 7 Topics: Azaguanine; Binding Sites; Crystallography, X-Ray; Guanine; Guanosine; Humans; Inosine; Ligands; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles	2005
Transition-state complex of the purine-specific nucleoside hydrolase of T. vivax: enzyme conformational changes and implications for catalysis. Journal of molecular biology, 2006, Jun-02, Volume: 359, Issue:2 Topics: Animals; Binding Sites; Crystallography, X-Ray; Ligands; Models, Molecular; Molecular Structure; N-Glycosyl Hydrolases; Protein Folding; Protein Structure, Quaternary; Protein Structure, Secondary; Purine Nucleosides; Pyrimidinones; Pyrroles; Trypanosoma vivax	2006
Forodesine, an inhibitor of purine nucleoside phosphorylase, induces apoptosis in chronic lymphocytic leukemia cells. Blood, 2006, Oct-01, Volume: 108, Issue:7 Topics: Antineoplastic Agents; Apoptosis; B-Lymphocytes; Caspases; DNA Damage; Enzyme Inhibitors; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphocytes; Mitochondria; Phosphorylation; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; T-Lymphocytes; Tumor Suppressor Protein p53	2006
Immucillins Impair Leishmania (L.) infantum chagasi and Leishmania (L.) amazonensis Multiplication In Vitro. PloS one, 2015, Volume: 10, Issue:4 Topics: Adenine; Adenosine; Animals; Antiprotozoal Agents; Cell Proliferation; Enzyme Inhibitors; Female; Humans; In Vitro Techniques; Kinetics; Leishmania infantum; Leishmania mexicana; Leishmaniasis, Cutaneous; Leishmaniasis, Visceral; Mice; Mice, Inbred BALB C; Microscopy, Electron, Transmission; N-Glycosyl Hydrolases; Purine Nucleosides; Pyrimidinones; Pyrroles; Pyrrolidines	2015