Page last updated: 2024-08-18

pyrroles and fluparoxan

pyrroles has been researched along with fluparoxan in 12 studies

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's10 (83.33)18.2507
2000's1 (8.33)29.6817
2010's1 (8.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Beresford, AP; Caswell, K; Chambers, R; Kirk, IP1
Halliday, CA; Jones, BJ; Skingle, M; Tyers, MB; Walsh, DM; Wise, H1
Gristwood, WE1
Blackwell, CP; Johnson, MA; Smith, J1
Abou-Saleh, MT; Collins, J; George, A; Rommelspacher, H1
Abou-Saleh, MT; Anderson, DN; Blair, JA; Cattell, RJ; Collins, J; Hamon, CG; Hughes, K1
Altria, KD1
Borthwick, AD; Brodie, AC; Cherry, PC; Crame, AJ; Kitchin, J; Pipe, AJ; Procopiou, PA; Seaman, MA; Turnbull, JP1
Colpaert, F; Marien, M; Tellez, S1
Ayrton, J; Beresford, AP; Ellis, WJ; Johnson, MA; Lewis, DF1
Audinot, V; Boutin, JA; Cogé, F; Cussac, D; Dekeyne, A; Galizzi, JP; Gobert, A; Lejeune, F; Millan, MJ; Newman-Tancredi, A; Nicolas, JP; Rivet, JM1
Borthwick, AD1

Reviews

1 review(s) available for pyrroles and fluparoxan

ArticleYear
Fluparoxan: A Comprehensive Review of its Discovery, Adrenergic and CNS Activity and Treatment of Cognitive Dysfunction in Central Neurodegenerative Diseases.
    Mini reviews in medicinal chemistry, 2017, Volume: 17, Issue:7

    Topics: Adrenergic Agents; Animals; Central Nervous System; Cognitive Dysfunction; Drug Discovery; Humans; Neurodegenerative Diseases; Piperoxan; Pyrroles

2017

Trials

2 trial(s) available for pyrroles and fluparoxan

ArticleYear
Antagonism of the effects of clonidine by the alpha 2-adrenoceptor antagonist, fluparoxan.
    British journal of clinical pharmacology, 1995, Volume: 39, Issue:5

    Topics: Administration, Oral; Adrenergic alpha-Antagonists; Adult; Antidepressive Agents; Blood Pressure; Bradycardia; Clonidine; Cross-Over Studies; Double-Blind Method; Growth Hormone; Heart Rate; Humans; Hypotension; Infusions, Intravenous; Male; Piperoxan; Psychomotor Performance; Pyrroles; Xerostomia

1995
Adrenoceptor activity and adenylate cyclase inhibition in depression.
    The British journal of psychiatry : the journal of mental science, 1994, Volume: 165, Issue:2

    Topics: Adenylyl Cyclase Inhibitors; Adult; Aged; Amitriptyline; Antidepressive Agents; Blood Platelets; Depressive Disorder; Female; Humans; Male; Middle Aged; Piperoxan; Pyrroles; Receptors, Adrenergic, alpha-2

1994

Other Studies

9 other study(ies) available for pyrroles and fluparoxan

ArticleYear
Advantages of achiral h.p.l.c. as a preparative step for chiral analysis in biological samples and its use in toxicokinetic studies.
    Xenobiotica; the fate of foreign compounds in biological systems, 1992, Volume: 22, Issue:7

    Topics: Animals; Calibration; Chromatography, High Pressure Liquid; Dogs; Female; Hydroxymethylglutaryl-CoA Synthase; Imidazoles; Male; Piperoxan; Pyrroles; Rats; Stereoisomerism

1992
The pharmacology of fluparoxan: a selective alpha 2-adrenoceptor antagonist.
    British journal of pharmacology, 1991, Volume: 102, Issue:4

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics; Animals; Aorta; Body Temperature; Brimonidine Tartrate; Clonidine; Guinea Pigs; Heart Rate; Ileum; In Vitro Techniques; Male; Muscle, Smooth; Norepinephrine; Piperoxan; Postural Balance; Pyrroles; Quinoxalines; Rabbits; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Dopamine; Receptors, Histamine; Receptors, Muscarinic; Receptors, Serotonin; Vas Deferens

1991
Determination of fluparoxan (GR50360) in plasma by gas chromatography.
    Journal of chromatography, 1990, May-18, Volume: 527, Issue:2

    Topics: Antidepressive Agents; Chromatography, Gas; Half-Life; Humans; Molecular Structure; Piperidines; Piperoxan; Pyrroles; Quality Control

1990
The role of pterins in depression and the effects of antidepressive therapy.
    Biological psychiatry, 1995, Oct-01, Volume: 38, Issue:7

    Topics: Adult; Aged; Amitriptyline; Antidepressive Agents; Biopterins; Clinical Trials as Topic; Depressive Disorder; Electroconvulsive Therapy; Female; Humans; Hydrocortisone; Male; Middle Aged; Neopterin; Piperoxan; Pyrroles; Pyrrolidinones; Reference Values; Rolipram

1995
Method validation.
    Methods in molecular biology (Clifton, N.J.), 1996, Volume: 52

    Topics: Adrenergic alpha-Antagonists; Capillary Action; Electrophoresis; Piperoxan; Pyrroles; Reproducibility of Results; Sensitivity and Specificity; Stereoisomerism

1996
Synthesis of benzodioxinopyrroles as selective alpha 2-adrenoceptor antagonists.
    Bioorganic & medicinal chemistry, 1995, Volume: 3, Issue:12

    Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; In Vitro Techniques; Male; Mice; Molecular Structure; Piperoxan; Pyrroles; Rats; Stereoisomerism

1995
Acetylcholine release in the rat prefrontal cortex in vivo: modulation by alpha 2-adrenoceptor agonists and antagonists.
    Journal of neurochemistry, 1997, Volume: 68, Issue:2

    Topics: Acetylcholine; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Clonidine; Guanabenz; Idazoxan; Imidazoles; Male; Microdialysis; Piperoxan; Prefrontal Cortex; Pyrroles; Quinoxalines; Rats; Rats, Sprague-Dawley

1997
Cytochrome P4501A (CYP1A) induction in rat and man by the benzodioxino derivative, fluparoxan.
    Xenobiotica; the fate of foreign compounds in biological systems, 1997, Volume: 27, Issue:2

    Topics: Adolescent; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Adult; Animals; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Enzyme Induction; Humans; Male; Microsomes, Liver; Molecular Structure; Piperoxan; Pyrroles; Rats; Rats, Sprague-Dawley

1997
Agonist and antagonist actions of yohimbine as compared to fluparoxan at alpha(2)-adrenergic receptors (AR)s, serotonin (5-HT)(1A), 5-HT(1B), 5-HT(1D) and dopamine D(2) and D(3) receptors. Significance for the modulation of frontocortical monoaminergic tr
    Synapse (New York, N.Y.), 2000, Volume: 35, Issue:2

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Antidepressive Agents; Body Temperature; Frontal Lobe; Guinea Pigs; Hippocampus; Humans; Mice; Neurons; Piperoxan; Pyrroles; Rats; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptors, Dopamine D2; Receptors, Dopamine D3; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Swine; Synaptic Transmission; Yohimbine

2000